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Professor Aideen Long
Professor, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Kelly AJ, Long A., Targeting T-cell integrins in autoimmune and inflammatory diseases., Clinical and experimental immunology, 215, (1), 2024, p15-26 Journal Article, 2024 DOI

Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023 Journal Article, 2023

Oleszycka E, O'Brien EC, Freeley M, Lavelle EC, Long A., Bile acids induce IL-1" and drive NLRP3 inflammasome-independent production of IL-1ß in murine dendritic cells., Frontiers in immunology, 14, 2023, p1285357 Journal Article, 2023 DOI

Leon, G. Hernandez-Santana, Y.E., Irwin, N., Giannoudaki, E., O'Neill, S., Czismadia, I., Gogarty, M., Lee, T.J., Ruane, D., Long, A., Fallon, P.G., Hussey, S. Walsh, P.T. , IL-36 cytokines imprint a colitogenic phenotype on CD4+ T helper cells., Mucosal Immunology, 2022 Journal Article, 2022 TARA - Full Text

Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022 Journal Article, 2022 DOI

Singh K, Cogan S, Elekes S, Murphy DM, Cummins S, Curran R, Najda Z, Dunne MR, Jameson G, Gargan S, Martin S, Long A, Doherty DG., SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or "" T cells., PloS one, 17, (7), 2022, pe0271463 Journal Article, 2022 DOI

Foran E., Freeley, M. Long A, L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner, Journal of Carcinogenesis and Mutagenesis, 13, (4), 2022, p390- Journal Article, 2022 TARA - Full Text

Giannoudaki E, Gargan S, Hussey S, Long A, Walsh PT., Opportunities to Target T Cell Trafficking in Pediatric Inflammatory Bowel Disease., Frontiers in pediatrics, 9, 2021, p640497 Journal Article, 2021 DOI

Thomas Phelan, Jean Dunne, Niall Conlon, Clíona Ní Cheallaigh, W. Mark Abbott, Raquel Faba-Rodriguez, Fatima Amanat, Florian Krammer, Mark A. Little, Gerry Hughes, Colm Bergin, Colm Kerr, Sudharshana Sundaresan, Aideen Long, William McCormack, Gareth Brady, Dynamic Assay for Profiling Anti-SARS-CoV-2 Antibodies and Their ACE2/Spike RBD Neutralization Capacity, Viruses, 13, (7), 2021, p1371 Journal Article, 2021 DOI

Quilty F, Freeley M, Gargan S, Gilmer J, Long A., Deoxycholic acid induces proinflammatory cytokine production by model oesophageal cells via lipid rafts., The Journal of steroid biochemistry and molecular biology, 214, 2021, p105987 Journal Article, 2021 DOI

Phipps SM, Garry CE, Kamal S, Johnson JD, Gilmer J, Long A, Kelleher D, Duggan SP., High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions., Cellular and molecular gastroenterology and hepatology, 10, (3), 2020, p601-622 Journal Article, 2020 DOI

Buoso E, Masi M, Long A, Chiappini C, Travelli C, Govoni S, Racchi M., Ribosomes as a nexus between translation and cancer progression: Focus on ribosomal Receptor for Activated C Kinase 1 (RACK1) in breast cancer., British journal of pharmacology, 2020 Journal Article, 2020 DOI

Quilty F, Byrne AM, Aird J, El Mashad S, Parra-Blanco A, Long A, Gilmer JF, Medina C., Impact of Deoxycholic Acid on Oesophageal Adenocarcinoma Invasion: Effect on Matrix Metalloproteinases., International journal of molecular sciences, 21, (21), 2020 Journal Article, 2020 DOI

Duggan, S.P. and Garry, C. and Behan, F.M. and Phipps, S. and Kudo, H. and Kirca, M. and Zaheer, A. and McGarrigle, S. and Reynolds, J.V. and Goldin, R. and Kalloger, S.E. and Schaeffer, D.F. and Long, A. and Strid, J. and Kelleher, D., siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth, Cellular and Molecular Gastroenterology and Hepatology, 5, (4), 2018, p569-590 Journal Article, 2018 DOI TARA - Full Text

Dunne PJ, Maher CO, Freeley M, Dunne K, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, CD3" Expression Defines Functionally Distinct Subsets of V"1 T Cells in Patients With Human Immunodeficiency Virus Infection., Frontiers in Immunology, 2018 Journal Article, 2018 TARA - Full Text

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS., RAB40C regulates RACK1 stability via the ubiquitin-proteasome system., Future science OA, 4, (7), 2018, pFSO317 Journal Article, 2018 DOI

Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J., Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients., Frontiers in immunology, 9, 2018, p1867 Journal Article, 2018 DOI TARA - Full Text

Brennan R, Haap-Hoff A, Gu L, Gautier V, Long A, Schröder M., Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3., European journal of cell biology, 2018 Journal Article, 2018 DOI

Prichard David O, Byrne Anne Marie, Murphy James O, Reynolds John V, O'Sullivan Jacintha, Feighery Ronan, Doyle Brendan, Eldin Osama Sharaf, Finn Stephen P, Maguire Aoife, Duff Deirdre, Kelleher Dermot P, Long Aideen, Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking , Journal of cellular and molecular medicine , 21 , (12 ), 2017, p3612 - 3625 Journal Article, 2017 TARA - Full Text URL DOI

Duff, D., Long, A., RACK1 in cancer cell migration and invasion, Cellular Signalling, 35, 2017, p250-255 Journal Article, 2017 DOI

Sharma R, Quilty F, Gilmer JF, Long A, Byrne AM., Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism., Oncotarget, 8, (1), 2017, p967 - 978 Journal Article, 2017 TARA - Full Text DOI

Gavin J, Quilty F, Majer F, Gilsenan G, Byrne A.M, Long A, Radics G, Gilmer J.F, A fluorescent analogue of tauroursodeoxycholic acid reduces ER stress and is cytoprotective, Bioorganic and Medicinal Chemistry Letters, 26, (21), 2016, p5369 - 5372 Journal Article, 2016 URL DOI

Freeley M, Derrick E, Dempsey E, Hoff A, Davies A, Leake D, Vermeulen A, Kelleher D, Long A., RNAi Screening with Self-Delivering, Synthetic siRNAs for Identification of Genes That Regulate Primary Human T Cell Migration, Journal of Biomolecular Screening, 2015, p943 - 956 Journal Article, 2015 URL

Anne-Marie Byrne , Spiros Bekiaris, Gina Duggan, David Prichard, Murat Kirca, Stephen Finn, John V Reynolds, Dermot Kelleher and Aideen Long, Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion, British Journal of Cancer, 113, 2015, p1332-1342 Journal Article, 2015 DOI TARA - Full Text

Molloy B, Freeley M, Long A, McManus R, Candidate Gene Knockdown in Celiac Disease., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p159-73 Journal Article, 2015 DOI

Long A and Freeley M, Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration., Biochemical Society Transactions, 42, (6), 2014, p1490 - 1497 Journal Article, 2014 URL

Ong, S.T., Freeley, M., Skubis-Zegad, J., (...), Verma, N.K., Long, A. , Phosphorylation of Rab5a protein by protein kinase Cε Is crucial for T-cell migration, Journal of Biological Chemistry, 289, (28), 2014, p19420-19434 Journal Article, 2014 DOI TARA - Full Text

Fahey S, Dempsey E, Long A, The role of chemokines in acute and chronic hepatitis C infection., Cellular & molecular immunology, 11, (1), 2014, p25-40 Journal Article, 2014 DOI TARA - Full Text

Májer F, Sharma R, Mullins C, Keogh L, Phipps S, Duggan S, Kelleher D, Keely S, Long A, Radics G, Wang J, Gilmer JF, New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid., Bioorganic & medicinal chemistry, 22, (1), 2014, p256-68 Journal Article, 2014 DOI TARA - Full Text

Fahey, Stephen , Dempsey, Eugene , Long, Aideen, The role of chemokines in acute and chronic hepatitis C infection, Cellular and Molecular Immunology, 11, (1), 2014, p25-40 Journal Article, 2014 DOI

Freeley M, Long A., The two hit hypothesis: an improved method for siRNA-mediated gene silencing in stimulated primary human T cells., Journal of immunological methods, 396, (1-2), 2013, p116-127 Journal Article, 2013 DOI

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578 Journal Article, 2013 TARA - Full Text DOI

Freeley M, Long A, Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection., Biochemical Journal, 455, (2), 2013, p133-47 Journal Article, 2013 TARA - Full Text DOI

Byrne G, Freeley M, Feighery C, Whelan A, Long A, Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease., Clinical immunology (Orlando, Fla.), 147, (1), 2013, p1-8 Journal Article, 2013

Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA., RACK1 to the future--a historical perspective., Cell communication and signaling : CCS, 11, 2013, p53 Journal Article, 2013 TARA - Full Text DOI

Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A, Hepatitis C virus - T-cell responses and viral escape mutations., European journal of immunology, 42, (1), 2012, p17-26 Journal Article, 2012 DOI

Freeley M, Long A, Regulating the Regulator: Phosphorylation of PKC " in T Cells., Frontiers in immunology, 3, (227), 2012, p1 - 2 Journal Article, 2012 TARA - Full Text URL

Freeley M, O'Dowd F, Paul T, Kashanin D, Davies A, Kelleher D, Long A, L-plastin regulates polarization and migration in chemokine-stimulated human T lymphocytes., Journal of immunology (Baltimore, Md. : 1950), 188, (12), 2012, p6357-6370 Journal Article, 2012 DOI

Verma NK, Dempsey E, Long A, Davies A, Barry SP, Fallon PG, Volkov Y, Kelleher D, Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-ß signaling., The Journal of biological chemistry, 287, (32), 2012, p27204-16 Journal Article, 2012 DOI TARA - Full Text

F Májer, JJ Salomon, R Sharma, SV Etzbach, MNM Najib, R Keaveny, A Long, J Wang, C Ehrhardt, JF Gilmer, New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid, Bioorg Med Chem, 20, (5), 2012, p1767-1778 Journal Article, 2012 DOI TARA - Full Text

Byrne AM, Sharma R, Duggan G, Kelleher D, Long A, Deoxycholic acid impairs glycosylation and fucosylation processes in esophageal epithelial cells., Glycobiology, 22, (5), 2012, p638-648 Journal Article, 2012 DOI TARA - Full Text

Verma NK, Dempsey E, Freeley M, Botting CH, Long A, Kelleher D, Volkov Y, Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells., Journal of Cellular Physiology, 226, (6), 2011, p1489-1498 Journal Article, 2011 DOI TARA - Full Text

Sharma R, Long A, Gilmer JF, Advances in bile acid medicinal chemistry., Current medicinal chemistry, 18, (26), 2011, p4029-52 Journal Article, 2011

de la Vega M, Kelvin AA, Dunican DJ, McFarlane C, Burrows JF, Jaworski J, Stevenson NJ, Dib K, Rappoport JZ, Scott CJ, Long A, Johnston JA, The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility., Nature Communications, 2, (259), 2011 Journal Article, 2011 DOI TARA - Full Text

Freeley, M., Kelleher, D. and Long, A. , Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites, Cellular Signalling, 23, (5), 2011, p753-762 Journal Article, 2011 TARA - Full Text

Fitzmaurice K, Petrovic D, Ramamurthy N, Simmons R, Merani S, Gaudieri S, Sims S, Dempsey E, Freitas E, Lea S, McKiernan S, Norris S, Long A, Kelleher D, Klenerman P, Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection., Gut, 60, (11), 2011, p1563-71 Journal Article, 2011 TARA - Full Text DOI

Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A, Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion., Hepatology (Baltimore, Md.), 53, (6), 2011, p1846 - 1853 Journal Article, 2011 URL DOI TARA - Full Text

Sharma R, Prichard D, Majer F, Byrne AM, Kelleher D, Long A, Gilmer JF, Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators., Journal of medicinal chemistry, 54, (1), 2011, p122-130 Journal Article, 2011 DOI

Kozak K, Bakos G, Hoff A, Bennett E, Dunican D, Davies A, Kelleher D, Long A, Csucs G, Workflow-based software environment for large-scale biological experiments., Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, 15, (7), 2010, p892-9 Journal Article, 2010 DOI

Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D, An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, down regulated in Barrett's oesophagus, which regulates NF-kB activation and cytokine levels., Carcinogenesis, 5, 2010, p936 - 945 Journal Article, 2010 URL DOI

Byrne AM, Foran E, Sharma R, Davies A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A, Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells., Carcinogenesis, 31, (4), 2010, p737-744 Journal Article, 2010 TARA - Full Text DOI

Freeley M, Bakos G, Davies A, Kelleher D, Long A, Dunican DJ., A high-content analysis toolbox permits dissection of diverse signaling pathways for T lymphocyte polarization., Journal of Biomolecular Screening., 15, (5), 2010, p541 - 555 Journal Article, 2010

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474 Journal Article, 2010 TARA - Full Text

Ruchika Sharma, Ferenc Majer, Vijaya Kumar Peta, Jun Wang, Ray Keaveney, Dermot Kelleher, Aideen Long and John F. Gilmer, Bile acid toxicity structure activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an esophageal cell line (HET-1A), Bioorganic & Medicinal Chemistry, 18, (18), 2010, p6886-6895 Journal Article, 2010 TARA - Full Text

Verma NK, Davies AM, Long A, Kelleher D, Volkov Y. , STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL, Cell Mol Biol Lett. , 15, (2), 2010, p342 - 355 Journal Article, 2010 TARA - Full Text

Verma NK, Dourlat J, Davies AM, Long A, Liu WQ, Garbay C, Kelleher D, Volkov Y., STAT3-stathmin interactions control microtubule dynamics in migrating T-cells., Journal of Biological Chemistry, 284, (18), 2009, p12349 - 12362 Journal Article, 2009

Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE., Statistical methods for analysis of high-throughput RNA interference screens. , Nature Methods, 6, (8), 2009, p569 - 575 Journal Article, 2009

Looby E, Abdel-Latif MM, Athié-Morales V, Duggan S, Long A, Kelleher D., Deoxycholate induces COX-2 expression via Erk1/2 - p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells, BMC Cancer, 9, (190), 2009 Journal Article, 2009 TARA - Full Text DOI

Lawler K, O'Sullivan G, Long A, Shear stress induces internalization of E-cadherin and invasiveness in metastatic oesophageal cancer cells by a Src-dependent pathway. , Cancer Science, 100, (6), 2009, p1082 - 1087 Journal Article, 2009

Freeley, M, Volkov Y, Kelleher D and Long A, Loss of PTEN expression does not contribute to PDK-1 activity and PKC_activation-loop phosphorylation in Jurkat T cells. , Cellular Signalling , 19, (12), 2007, p2444 - 2457 Journal Article, 2007

Gruber T, Freeley M, Thuille N, Heit I, Shaw S, Long A, Baier G. , Comment on "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation"., Science, 312, (5770), 2006, p55 - 55 Journal Article, 2006 URL

Volkov Y, , Long A, , Freeley M, Golden-Mason L, O'Farrelly C, Murphy A, Kelleher D., The Hepatitis C Envelope 2 Protein Inhibits LFA-1-Transduced Protein Kinase C Signaling for T-Lymphocyte Migration. , Gastroenterology, 130, (2), 2006, p482 - 492 Journal Article, 2006

Lawler KM, Foran E, O'sullivan G, Long A, , Kenny D, The mobility and invasiveness of metastatic esophageal cancer is potentiated by shear stress in a ROCK and Ras dependent manner. , Am J Physiol Cell Physiol, 291, (4), 2006, pC668 - 677 Journal Article, 2006

Foran E, McWilliam P, Kelleher D, Croke DT, Long A., The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells., International Journal of Cancer, 118, (8), 2006, p1098 - 2104 Journal Article, 2006

Shah SA, Looby E, Volkov Y, Long A and Kelleher D, Ursodeoxycholic Acid Inhibits Deoxycholic Acid-induced Translocation of Protein Kinase C alpha, PKC beta 1, PKC epsilon and PKC delta in Human Colonic Cancer Cell Lines., European Journal of Cancer, 41, (14), 2005, p2160 - 2169 Journal Article, 2005

Freeley M, Volkov Y, Kelleher D and Long A. , Stimulus-induced phosphorylation of PKC ? at the C-terminal hydrophobic motif in human T lymphocytes., Biochem. Biophys. Research Communications., 334, (2), 2005, p619 - 630 Journal Article, 2005

O' Toole D,. Abdel-Latif MM, Long A, Windle HJ, Murphy AM, Bowie A, O' Neill LAJ, Weir DJ, and Kelleher D., Low pH and Helicobacter pylori increases Nuclear Factor Kappa B binding in gastric epithelial cells: A common pathway for epithelial cell injury?, J Cell Biochem, 96, (3), 2005, p589 - 598 Journal Article, 2005

Looby E, Long A, Kelleher D, Volkov Y. , Bile acid deoxycholate induces differential subcellular localisation of the PKC isoenzymes beta(1), epsilon and delta in colonic epithelial cells in a sodium butyrate insensitive manner. , International Journal of Cancer, 114, (6), 2005, p887 - 895 Journal Article, 2005

Fanning A , Volkov Y , Freeley M , Kelleher D , and Long A. , CD44 cross-linking induces PKC-regulated migration of human T lymphocytes., International Immunology, 17, (4), 2005, p449 - 458 Journal Article, 2005

El Din El Homasany BS, Volkov Y, Takahashi M, Ono Y, Keryer G, Delouvee A, Looby E, Long A, , Kelleher D, . , The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells., Journal of Immunology, 175, (12), 2005, p7811 - 7818 Journal Article, 2005

Murphy JF, Lennon F, Steele C, Kelleher D, Fitzgerald D, Long A., Engagement of CD44 modulates cyclooxygenase induction, VEGF generation, and cell proliferation in human vascular endothelial cells. , FASEB Journal, 19, (3), 2005, p446 - 448 Journal Article, 2005

Nugent AP, Roche HM, Noone EJ, Long A, Kelleher DK, Gibney MJ., The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers., European Journal Clinical Nutrition, 59, (6), 2005, p742 - 750 Journal Article, 2005

Long A, Mitchell S, Kashanin D, Williams V, Prina Mello A, Shvets I, Kelleher D, Volkov Y., A multidisciplinary approach to the study of T cell migration, Annals of the New York Academy of Sciences, 1028, 2004, p313 - 319 Journal Article, 2004

Volkov Y, Long A, McGrath S, Ni Eidhin D and Kelleher D. , Crucial importance of PKC?(I) in LFA-1-mediated locomotion of activated T cells., Nature Immunology , 2, (6), 2001, p508 - 514 Journal Article, 2001

Long A., Kelleher D., Lynch S., Volkov Y., Cutting edge: protein kinase C beta expression is critical for export of Il-2 from T cells, Journal of Immunology, 167, (2), 2001, p636-640 Journal Article, 2001 URL TARA - Full Text

Farrell RJ, Murphy A, Long A, Donnelly S, Cherikuri A, O'Toole D, Mahmud N, Keeling PW, Weir DG, Kelleher D., High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. , Gastroenterology, 118, (2), 2000, p279 - 288 Journal Article, 2000

Murphy A, Long A, Volkov Y and Kelleher D. , Cross linking of LFA-1 induces secretion of chemokines MIP-1 alpha and MIP-1 beta with consequent directed migration of activated lymphocytes. , European Journal of Immunology , 30, 2000, p3012 - 3020 Journal Article, 2000

Volkov Y, Long A and Kelleher D , Inside the crawling T cell: LFA-1 cross-linking causes microtubule-directed translocation of Protein kinase C isoenzymes ? (I) and ?. , Journal of Immunology, 161, 1998, p6487 - 6495 Journal Article, 1998

Keenan C, Long A and Kelleher D., Protein Kinase C and T cell function. , Biochem. Biophys Acta , 1358, 1997, p113-126 Review, 1997

Ahem S, Long, A, and Kelleher D, Constitutive expression of multiple CD44 variants on peripheral blood mononuclear cells (PBMC) using Western blotting techniques, Immunology Letters , 56, 1997, p256 - 257 Journal Article, 1997

O'Connell MA, Kelleher D, Liskamp RM, Hall N, O'Neill LA, Long A, TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes., Cytokine, 9, (2), 1997, p83-92 Journal Article, 1997

Keenan C, Long A, Volkov Y and Kelleher D. , Protein Kinase C Isotypes ?, ?_and ? in human lymphocytes. Differential responses to signaling through the T cell receptor and phorbol esters. , Immunology, 90, 1997, p557 - 563 Journal Article, 1997

Keenan C, Volkov Y, Kelleher D and Long A, Subcellular Localisation and Translocation of Protein Kinase C isoforms ? and ? in Human Peripheral Blood Lymphocytes. , International Immunology, 9, 1997, p1431 - 1439 Journal Article, 1997

Wingett D, Long A, Kelleher D and Magnuson NS., pim-1 Proto- Oncogene Expression in Anti-CD3-Mediated T Cell Activation is associated with Protein Kinase C Activation and is Independent of raf-1, Journal of Immunology, 156, 1996, p549 - 557 Journal Article, 1996

Fan Xuejun, Long A., Goggins M, Fan Xuegong, Keeling PWN and Kelleher D, Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. , Gut, 38, 1996, p507 - 512 Journal Article, 1996

Kelleher D, Murphy A, Hall N, Kearns G, Omary M B, Long, A and Casey E B, Expression of CD44 on rheumatoid synovial fluid lymphocytes. , Annals of the Rheumatic Diseases, 54, 1995, p566 - 570 Journal Article, 1995

Corrigan E, Kelleher D, Feighery C and Long A, Protein Kinase C expression in CD45RA+ and CD45RO+ T lymphocytes., Immunology, 85, 1995, p299 - 303 Journal Article, 1995

Keenan C, Kelleher D and Long, A, Regulation of non-classical Protein Kinase C isozymes in a human T cell line. , European Journal of Immunology, 25, 1995, p13 - 17 Journal Article, 1995

O' Connell MA, Cleere R, Long A, O'Neill LAJ and Kelleher, D., Proliferation and Activation of NFkB are induced by Autocrine Production of Tumour Necrosis Factor _ in the T Lymphoma line HuT 78, Journal of Biological Chemistry, 270, 1995, p7399 - 7404 Journal Article, 1995

Cleere R, Long A, Kelleher D and O'Neill LAJ, Autocrine regulation of NF_B by TNF in HuT 78 T lymphoma cells., Biochemical Society Transactions, 1, 1995, p113s- Journal Article, 1995

Fan Xuejun,. Long A, Fan Xuegong, Keeling PWN and Kelleher D., Adhesion molecule expression on gastric intra-epithelial lymphocytes of patients with Helicobacter pylori infection. , European Journal of Immunology, 7, 1995, p541 - 546 Journal Article, 1995

. Kelleher D, Murphy A, Shiels O, Long A and Mc Devitt J., Phosphotyrosine expression in the human duodenum, Gut, 36, 1995, p34 - 38 Journal Article, 1995

Donnelly S, Kelleher D and Long A., Regulation of migration and activation of cells of the immune system: A fundamental process in mammalian pathology., Journal of Biomedical Science, 4, 1994, p78 - 85 Journal Article, 1994

A. Long, M. O'Connell, R. M. Liskamp and D. Kelleher, Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line, Immunology, 80, (4), 1993, p654-7 Journal Article, 1993 URL TARA - Full Text

A. Long and D. Kelleher, Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line, FEBS letters, 333, (3), 1993, p243-7 Journal Article, 1993 URL

A. Murphy, K. C. Breen, A. Long, C. Feighery, E. B. Casey and D. Kelleher, Neurofilament expression in human T lymphocytes, Immunology, 79, (1), 1993, p167-170 Journal Article, 1993 TARA - Full Text

Kelleher D and Long A, Development and Characterisation of a Protein Kinase C? isozyme-deficient T cell line., FEBS Letters, 301, 1992, p310 - 314 Journal Article, 1992

Niklova P, Long A and Ward OP, Colorimetric determination of L-Phenylacetyl carbinol produced by biotransformation of benzaldehyde and pyruvate using Saccharomyces cerevisiae. , Biotechnology Techniques , 5, 1991, p31 - 34 Journal Article, 1991

Long A, James P and Ward OP, Aromatic aldehydes as substrates for yeast and yeast alcohol dehydrogenase, Biotechnology and Bioengineering, 33, 1989, p657 - 660 Journal Article, 1989

Long A, James P and Ward OP, Biotransformation of aromatic aldehydes by Saccharomyces cerevisiae: investigation of reaction rates, Journal of Industrial Microbiology , 4, 1989, p49 - 53 Journal Article, 1989

Long A and Ward OP, Biotransformation of benzaldehyde by Saccharomyces cerevisiae: characterisation of the fermentation and toxicity effects of substrates and products., Biotechnology and Bioengineering, 34, 1989, p933 - 941 Journal Article, 1989

Research Expertise


Biomedical sciences; Cellular, molecular and developmental immunology; Chronic inflamation; Hepatitis C; Host, Pathogen interactions; Imaging Techniques; Immune system; Immunoassays; Infectious diseases; Innate immunology; Intra and intercellular signalling; Leukocyte Biology; Membrane and protein trafficking; Oesophageal cancer; Oesophageal, gastric, intestinal and pancreatic diseases; Virology and viral pathogenesis



External Assessor PhD programme University College Cork 2010-2013

Awards and Honours

Trinity College Dublin Innovation Award (Societal Impact Award) 2020

Fellow of Trinity College Dublin 2012

MA (jo) Trinity College Dublin 2009

Elected President of the Irish Society for Immunology 2007

Awarded Wellcome Trust Research Fellowship (Career Development Award) - first to receive such an award in Ireland 1994

Teaching Assistant of the Year Award, University of Waterloo, Ontario Canada 1989

Industrial Liaison Scholarship, Dublin City University 1985-88

1st place in class BSc Biochem UCD 1985