Prof. Jacintha O'Sullivan
Professor in Translational Oncology and Education Lead for the Trinity St. James’s Cancer Institute
- Research Institute:
Trinity Translational Medicine Institute (TTMI)
- Contact e-mail:
- Research Area(s):
Gastrointestinal inflammatory diseases and cancers; Tumour microenvironment- cross talk to immune cells; Treatment resistance; Drug Discovery; Metabolism; Inflammation; Angiogenesis; Hypoxia; Inflammatory and cancer Ex vivo models; Diagnostic platforms
Research Description:
Prof. O Sullivan directs a translational gastrointestinal (GI) research team in the Trinity Translational Medicine Institute (TTMI) in collaboration with clinical and surgical colleagues and patient involvement. She is also the Education lead for the Trinity St. James’s Cancer Institute. She utilises well established bio-banking structures to drive this GI translational research program. Prof. O Sullivan's current translational research themes include:
1. Development of diagnostic platforms to stratify cancer risk and response to targeted therapies for gastrointestinal diseases.
2. Development of novel patented therapeutics to be used in the neoadjuvant and adjuvant treatment setting for gastrointestinal cancer patients (Colorectal and Oesophageal cancers).
3. Elucidating how the tumour microenvironment cross talks to the immune system in Gastrointestinal diseased patients.
4. Importance of metabolism, inflammation, and obesity in driving disease progression and in regulating treatment response in GI diseases.
5. Advancing new experimental technologies to boost treatment response in the resistant tumour microenvironment. The outputs of these translational themes will benefit patient care, treatment and management for gastrointestinal diseased patients.
