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Professor Ross Mc Manus
Professor in Molecular Medicine, Clinical Medicine
Professor in Molecular Medicine, Molecular Medicine Ireland

Publications and Further Research Outputs

Peer-Reviewed Publications

Coakley J.D., Breen E., Moreno-Olivera A., Al-Harbi A., Melo A., O'Connell B., McManus R., Doherty D., Ryan T. , Innate lymphocyte Th1 and Th17 responses in elderly hospitalised patients with infection and sepsis., Vaccines, 8, (2), 2020, p311- Journal Article, 2020 URL DOI

Castro P.D., Harkin G., Hussey M., Christopher B., Kiat C., Chin J.L., Trimble V., McNamara D., MacMathuna P., Egan B., Ryan B., Kevans D., Abuzakouk M., Farrell R., Feighery C., Byrnes V., Mahmud N., McManus R., Prevalence of coexisting autoimmune thyroidal diseases in coeliac disease is decreasing, United European Gastroenterology Journal, 2020 Journal Article, 2020 DOI

Ní Chonchubhair H.M., Duggan S.N., Egan S.M., Kenyon M., O'Toole D., McManus R., Conlon K.C. , A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland., HPB Journal, 2020 Journal Article, 2020

Romero-Ortuno R, Kenny RA, McManus R, Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans, Experimental Gerontology, 129, 2019, p110781 - Journal Article, 2019 URL DOI

Coakley JD, Breen EP, Moreno-Olivera A, Al-Harbi AI, Melo AM, O'Connell B, McManus R, Doherty DG, Ryan T., Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis, PLoS One, 14, (10), 2019, pe0224276- Journal Article, 2019 DOI

Radian S, Diekmann Y, Gabrovska P, Holland B, Bradley L, Wallace H, Stals K, Bussell AM, McGurren K, Cuesta M, Ryan AW, Herincs M, Hernández-Ramírez LC, Holland A, Samuels J, Aflorei ED, Barry S, Dénes J, Pernicova I, Stiles CE, Trivellin G, McCloskey R, Azjensztejn M, Abid N, Akker SA, Mercado M, Cohen M, Thakker RV, Baldeweg S, Barkan A, Musat M, Levy M, Orme S, Unterländer M, Burger J, Kumar AV, Ellard S, McPartlin J, McManus R, Linden GJ, Atkinson B, Balding D, Agha A, Thompson CJ, Hunter SJ, Thomas MG, Morrison PJ, Korbonits M., Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland, Human Mutation, 2017, p78-85 Journal Article, 2017 DOI TARA - Full Text

Bowes J, Ashcroft J, Dand N, Jalali-najafabadi F, Bellou E, Ho P, Marzo-Ortega H, Helliwell P, Feletar M, Ryan A, Kane D, Korendowych E, Simpson M, Packham J, McManus R, Brown M, Smith C, Barker J, McHugh N, FitzGerald O, Warren R, Barton A. , Cross phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis , Annals of Rheumatic Diseases, 76, (10), 2017, p1774 - 1779 Journal Article, 2017 DOI

Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Jun Liong Chin, Deirdre McNamara, Padraic MacMathuna, Brian J. Egan, Barbara Ryan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, Co-Existence of Celiac Disease and other Immune-Mediated Conditions in Celiac Patients, Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, Chicago, IL, USA, 7 May 2017, 152, (5), Elsevier , 2017, ppS483 - S484 Poster, 2017 DOI

Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Jun Liong Chin, Deirdre McNamara, Padraic MacMathuna, Brian J. Egan, Barbara Ryan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, Pattern of Thyroid Disease Presentation in a Cohort of Celiac Patients Diagnosed from 1960-2015, Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, Chicago, IL, USA, 7 May 2017, 152, (5), Elsevier , 2017, ppS484 - S484 Poster, 2017 DOI

Dominguez Castro P, Harkin G, Hussey M, Christopher B, Kiat C, Chin JL, Trimble V, McNamara D, MacMathuna P, Egan B, Ryan B, Kevans D, Farrell R, Byrnes V, Mahmud N, McManus R. , Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015, Clinical Gastroenterology and Hepatology, 15, (1), 2017, p864 - 871 Journal Article, 2017 DOI

Patricia Dominguez Castro, Grace Harkin, Mary Hussey, Brian Christopher, Clifford Kiat, Deirdre McNamara, Padraic MacMathuna, Brian Egan, David Kevans, Richard Farrell, Valerie Byrnes, Ross McManus, A Description of the clinical phenotype of coeliac disease in Ireland; Cross-sectional Study and 55 Year Perspective., Gastroenterology, American Gastroenterology Society/ Digestive Disease Week, San Diego, California, USA, 25 May 2016, 150, (4), Elsevier , 2016, ppS-205 - S-206 Oral Presentation, 2016 URL DOI

Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338 Journal Article, 2016 DOI URL

A. Budu-Aggrey, J. Bowes, S. Lohr, S. Uebe, M.I. Zervou, P. Helliwell, A.W. Ryan, D. Kane, E. Korendowych, E. Giardina, J. Packham, R. McManus, O. FitzGerald, N. McHugh, F. Behrens, H. Burkhardt, U. Huffmeier, P. Ho, J. Martin, S. Castañeda, G. Goulielmos, A. Reis, A. Barton, Replication of A Distinct Psoriatic Arthritis Risk Variant at IL23R, Annals of the Rheumatic Diseases, EULAR - Annual European Congress of Immunology, Frankfurt, Germany, 3 June 2016, 75, (S2), BMJ Journals, 2016, pp667 - 668 Poster, 2016 DOI

Budu-Aggrey A, Bowes J, Loehr S, Uebe S, Zervou M.I, Helliwell P, Ryan A.W, Kane D, Korendowych E, Giardina E, Packham J, McManus R, Fitzgerald O, McHugh N, Behrens F, Burkhardt H, Huffmeier U, Ho P, Martin J, Castañeda S, Goulielmos G, Reis A, Barton A, Replication of a distinct psoriatic arthritis risk variant at the IL23R locus, Annals of the Rheumatic Diseases, 75, (7), 2016, p1417 - 1418 Journal Article, 2016 URL TARA - Full Text DOI

Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 Journal Article, 2016 DOI

Coleman C, Quinn E.M, Ryan A.W, Conroy J, Trimble V, Mahmud N, Kennedy N, Corvin A.P, Morris D.W, Donohoe G, O'Morain C, MacMathuna P, Byrnes V, Kiat C, Trynka G, Wijmenga C, Kelleher D, Ennis S, Anney R.J.L, McManus R, Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci, European Journal of Human Genetics, 24, 2016, p291 - 297 Journal Article, 2016 URL DOI TARA - Full Text

Quinn EM, McManus R, Quality Control and Analysis of NGS RNA Sequencing Data., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p217-32 Journal Article, 2015 DOI

Candidate Gene Knockdown in Celiac Disease. in, Methods in Molecular Biology, 2015, pp159 - 173, [Molloy B, Freeley M, Long A, McManus R] Book Chapter, 2015 URL

Quinn EM, Coleman C, Molloy B, Dominguez Castro P, Cormican P, Trimble V, Mahmud N, McManus R, Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFN" Regulation., PloS One, 10, (10), 2015, pe0140049 Journal Article, 2015 TARA - Full Text DOI

Molloy B, McManus R, Cloning Gene Variants and Reporter Assays., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p117-30 Journal Article, 2015 DOI

Molloy B, Freeley M, Long A, McManus R, Candidate Gene Knockdown in Celiac Disease., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p159-73 Journal Article, 2015 DOI

Bowes, J. Budu-Aggrey, A. Huffmeier, U. Uebe, S. Steel, K. Hebert, H.L. Wallace, C. Massey, J. Bruce, I.N. Bluett, J. Feletar, M. Morgan, A.W. Marzo-Ortega, H. Donohoe, G. Morris, D.W. Helliwell, P. Ryan, A.W. Kane, D. Warren, R.B. Korendowych, E. Alenius, G.-M. Giardina, E. Packham, J. McManus, R. Fitzgerald, O. McHugh, N. Brown, M.A. Ho, P. Behrens, F. Burkhardt, H. Reis, A. Barton, A., Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis, Nature Communications, 6, 2015, p6046- Journal Article, 2015 URL DOI TARA - Full Text

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert H.L, Wallace C, Massey J, Bruce I.N, Bluett J, Feletar M, Morgan A.W, Marzo-Ortega H, Donohoe G, Morris D.W, Helliwell P, Ryan A.W, Kane D, Warren R.B, Korendowych E, Alenius G.-M, Giardina E, Packham J, McManus R, Fitzgerald O, McHugh N, Brown M.A, Ho P, Behrens F, Burkhardt H, Reis A, Barton A, Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis (Nature Communications (2015) 6 (6046) DOI:10.1038/ncomms7046), Nature Communications, 6, 2015 Journal Article, 2015 DOI URL

Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J, Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus., Gastroenterology, 148, (2), 2015, p367-78 Journal Article, 2015 DOI TARA - Full Text

Coleman C, Quinn EM, McManus R, Quality Control Procedures for High-Throughput Genetic Association Studies., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p203-15 Journal Article, 2015 DOI

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., The Journal of allergy and clinical immunology, 2015 Journal Article, 2015 TARA - Full Text DOI

Bowes J, Loehr S, Budu-Aggrey A, Uebe S, Bruce IN, Feletar M, Marzo-Ortega H, Helliwell P, Ryan AW, Kane D, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, Brown MA, Behrens F, Burkhardt H, McHugh N, Huffmeier U, Ho P, Reis A, Barton A., PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus, Annals of the Rheumatic Diseases, 74, 2015, p1882 - 1885 Journal Article, 2015 TARA - Full Text DOI

Grealy, R., White, M., Stordeur, P., Kelleher, D., Doherty, D.G., McManus, R., Ryan, T., Characterising cytokine gene expression signatures in patients with severe sepsis, Mediators of Inflammation, 2013, 2013, part. no. 164246 Journal Article, 2013 TARA - Full Text DOI

Apel M, Uebe S, Bowes J, Giardina E, Korendowych E, Juneblad K, Pasutto F, Ekici AB, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Padyukov L, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A, Hüffmeier U., Variants in RUNX3 contribute to susceptibility to psoriatic arthritis exhibiting further common ground with ankylosing spondylitis, Arthritis & Rheumatism, 2013, p00-00 Journal Article, 2013 DOI

Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van der Laan LJ, Kuipers EJ, Drenth JP, Peters WH, Reynolds JV, Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath K, Siersema PD, van Baal JW, Middleton M, Petty R, Gillies R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Patel P, Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, MacDonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, Gibbons M, Cullen S, Church N, Langley R, Griffin M, Alderson D, Deloukas P, Hunt SE, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Anderson M, Brooks C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood N, Trynka G, Wijmenga C, Cazier JB, Atherfold P, Nicholson AM, Gellatly NL, Glancy D, Cooper SC, Cunningham D, Lind T, Hapeshi J, Ferry D, Rathbone B, Brown J, Love S, Attwood S, MacGregor S, Watson P, Sanders S, Ek W, Harrison RF, Moayyedi P, de Caestecker J, Barr H, Stupka E, Vaughan TL, Peltonen L, Spencer CC, Tomlinson I, Donnelly P, Jankowski JA, Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus., Nature genetics, 44, (10), 2012, p1131-6 Journal Article, 2012 DOI

Babar M, Ryan AW, Anderson LA, Segurado R, Turner G, Murray LJ, Murphy SJ, Johnston BT, Comber H, Reynolds JV, McManus R, Genes of the Interleukin-18 pathway are associated with susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma, American Journal of Gastroenterology, 107, (9), 2012, p1331-1341 Journal Article, 2012 DOI

Thomas Ryan, Mary White, Owen Ross McManus, Dermot Kelleher, Patrick Stordeur, Vincent Young, 'Cytokines as prognostic markers of respiratory-tract infection following major surgery', European Patent Agency, US Patent and Trademark Office, WO2010064223, 2012 Patent, 2012 Other

Phillips CM, Kesse-Guyot E, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults., The Journal of nutrition, 142, (5), 2012, p824-831 Journal Article, 2012 DOI

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity., Nature genetics, 44, (12), 2012, p1341-1348 Journal Article, 2012 DOI

Bowes J, Ho P, Flynn E, Marzo-Ortega H, UKRAG Consortium, Coates L, McManus R, Ryan A, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A, Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort, Annals of Rheumatic Diseases, 71, (8), 2012, p1350-1354 Journal Article, 2012 DOI TARA - Full Text

Catherine M Phillips, Emmanuelle Kesse-Guyot, Namanjeet Ahluwalia, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells, Helen M Roche, Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk, Atherosclerosis, 220, (2), 2012, p513-519 Journal Article, 2012 TARA - Full Text DOI

Knight J, Spain SL, Capon F, Hayday A, Nestle FO, Clop A, Wellcome Trust Case Control Consortium, Genetic Analysis of Psoriasis Consortium§, I-chip for Psoriasis Consortium, Barker JN. Weale ME, Trembath RC, Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis, Human Molecular Genetics, 21, (23), 2012, p5185 - 5192 Journal Article, 2012 TARA - Full Text DOI

White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158 Journal Article, 2011 DOI URL TARA - Full Text

Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy G, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK, Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock, Immunity, 34, 2011, p715 - 728 Journal Article, 2011 TARA - Full Text DOI

Phillips CM, L Goumidi, Bertrais S, Field MR, McManus R, S Hercberg, Lairon D, Planells R, Roche HM, Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome, Journal of Nutritional Biochemistry, 23, (3), 2011, p239-244 Journal Article, 2011 DOI

White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T, Hospital acquired pneumonia after lung resection surgery displays characteristic cytokine profiles, Chest, 139, 2011, p626 - 632 Journal Article, 2011 DOI

Catherine M. Phillips, Louisa Goumidi, Sandrine Bertrais, Martyn R. Field, Ross McManus, Serge Hercberg, Denis Lairon, Richard Planells and Helen M. Roche, Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk, Atherosclerosis, 214, (2), 2011, p408-414 Journal Article, 2011 TARA - Full Text

Bowes J, Eyre S, Flynn E, Ho P, Salah S, Warren RB, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, Fitzgerald O, Packham J, Morgan AW, Griffiths CE, Bruce IN, Worthington J, Barton A, Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris., Annals of the Rheumatic Diseases, 70, (6), 2011, p1016 - 1019 Journal Article, 2011 DOI TARA - Full Text

Hughes DJ, McManus R, Neary P, O'Morain C, O'Sullivan M, Common Variation in the Vitamin D Receptor Gene and Risk of Inflammatory Bowel Disease in an Irish Case-Control Study, European Journal of Gastroenterology & Hepatology , 23, 2011, p807 - 812 Journal Article, 2011 DOI

Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, Brouwer E, Posthumus MD, Remmers EF, Tucci F, Toes R, Grandone E, Mazzilli MC, Rybak A, Cukrowska B, Coenen MJ, Radstake TR, van Riel PL, Li Y, de Bakker PI, Gregersen PK, Worthington J, Siminovitch KA, Klareskog L, Huizinga TW, Wijmenga C, Plenge RM, Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared Loci., PLoS genetics, 7, (2), 2011, pe1002004 Journal Article, 2011 DOI TARA - Full Text

Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, FitzGerald O, Packham J, Morgan AW, Bruce IN, Barton A, Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis, Annals of Rheumatic Diseases , 70, 2011, p1641 - 1644 Journal Article, 2011 DOI TARA - Full Text

Dubois PCA, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Ádány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek , Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA, Multiple common variants for celiac disease influencing immune gene expression, Nature Genetics, 42, (4), 2010, p295 - 302 Journal Article, 2010 TARA - Full Text DOI URL

Bowes J, Flynn E, Ho P, Aly B, Morgan AW, Marzo-Ortega H, Coates L, McManus R, Ryan AW, Kane D, Korendowych E, McHugh N, Fitzgerald O, Packham J, Bruce IN, Barton A, Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis, Annals of Rheumatic Diseases, 69, (12), 2010, p2199-2203 Journal Article, 2010 TARA - Full Text

Thomas Ryan, Dermot Kelleher, Owen Ross McManus, Michael O'dwyer, Patrick Stordeur, 'A method for detecting or monitoring sepsis by analysing cytokine mRNA expression levels', European Patent Agency, US Patent and Trademark Office, WO2007060647, 2010 Patent, 2010 URL

Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Lascorz J, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, FitzGerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A, Variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis, Nature Genetics, 42, 2010, p996 - 999 Journal Article, 2010 DOI

White M, Lawless MW, O'Dwyer MJ, Grealy R, O'Connell B, Stordeur P, Kelleher D, McManus R*, Ryan T*, Transforming Growth Factor beta-1 and Interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection, Cytokine, 50, 2010, p322 - 327 Journal Article, 2010 DOI

Brophy K*, Ryan AW*, Turner G, Trimble V, Patel KD, O'Morain C, Kennedy NP, Egan B, Close E, Lawlor G, MacMathuna P, Stevens FM, Abuzakouk M, Feighery C, Kelleher D, McManus R, Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study, BMC Medical Genetics, 11, (76), 2010 Journal Article, 2010 TARA - Full Text URL

Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Mehegan J, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM, Additive Effect of Polymorphisms in the IL-6, LTA, and TNF-{alpha} Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components., The Journal of clinical endocrinology and metabolism, 95, 2010, p1386 - 1394 Journal Article, 2010 DOI

Phillips CM, Goumidi L, Bertrais S, Field MR, Ordovas JM, Cupples LA, Defoort C, Lovegrove JA, Drevon CA, Blaak EE, Gibney MJ, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults., The Journal of nutrition, 140, (2), 2010, p238-44 Journal Article, 2010 DOI

Strange A, Capon F, Spencer CC, Knight J, Weale M, Allen M, Barton A, Band G, Bellenguez C, Bergboer J, Blackwell J, Bramon E, Bumpstead S, Casas J, Cork M, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt S, Irvine A, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus H, Mathew C, McLean W, McManus R, Mössner R, Moutsianas L, Naluai Å, Nestle F, Novelli G, Onoufriadis A, Palmer C, Perricone C, Pirinen M, Plomin R, Potter S, Pujol R, Rautanen A, Riveira-Munoz E, Ryan A, Salmhofer W, Samuelsson L, Sawcer S, Schalkwijk J, Smith C, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan A, Warren R, Weger W, Wolk K, Wood N, Worthington J, Young H, Zeeuwen P, Hayday A, Burden A, Griffiths C, Kere J, Reis A, McVean G, Evans D, Brown M, Barker J, Peltonen L, Donnelly P, Trembath R, Identification of novel psoriasis susceptibility loci and genetic interaction between HLA-C and ERAP1 provides evidence for an integrated pathogenic pathway., Nature Genetics, 42, 2010, p985 - 990 Journal Article, 2010 DOI

Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, ACC2 gene polymorphisms, metabolic syndrome and gene-nutrient interactions with dietary fat, Journal of Lipid Research, 51, (12), 2010, p3500-3507 Journal Article, 2010 DOI

Phillips, CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome, Journal of Lipid Research, 51, 2010, p3500 - 3507 Journal Article, 2010

Phillips CM, Goumidi L, Bertrais S, Ferguson JF, Field MR, Kelly ED, Peloso GM, Cupples LA, Shen J, Ordovas JM, McManus R, Hercberg S, Portugal H, Lairon D, Planells R, Roche HM, Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome., The American journal of clinical nutrition, 90, (6), 2009, p1665-73 Journal Article, 2009 DOI

Romanos J, van Diemen CC, Nolte IM, Trynka G, Zhernakova A, Fu J, Bardella MT, Barisani D, McManus R, van Heel DA, Wijmenga C., Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease, Gastroenterology , 137, (133), 2009, p834-840 Journal Article, 2009 DOI

Mankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine , 13, (4), 2009, p631-643 Journal Article, 2009 TARA - Full Text

Patel KD, Duggan SP, Currid CA, Gallagher WM, McManus R, Kelleher D, Murphy RT, Ryan AW, High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of interferon gamma and interleukin-10 post myocardial infarction., Clinical immunology (Orlando, Fla.), 133, (2), 2009, p251-6 Journal Article, 2009 DOI

Feighery CF, McManus R., Symposium on 'The challenge of translating nutrition research into public health nutrition'. Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease'. Recent advances in genetic understanding of coeliac disease. , Proceedings of the Nutrition Society, 68, (2), 2009, p122-126 Journal Article, 2009 TARA - Full Text

Murphy G, Thornton J, McManus R, Swan N, Ryan B, Hughes D, O'Morain C, O'Sullivan M, Association of gastric disease with polymorphisms in the inflammatory related genes IL-1B, IL-1RN, IL-10, TNF and TLR4 , European Journal of Gastroenterology and Hepatology, 21, (6), 2009, p630-635 Journal Article, 2009 DOI

Phillips CM, Goumidi L, Bertrais S, Field MR, Peloso GM, Shen J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM, Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults., The Journal of nutrition, 139, (11), 2009, p2011-7 Journal Article, 2009 DOI

Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C, Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling., Gut, 58, (8), 2009, p1078-83 Journal Article, 2009 DOI

O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T* , Variability in IL-23 and IL-27 gene expression may determine patient response to a septic insult, Intensive Care Medicine, 34, (4), 2008, p683 - 691 Journal Article, 2008 DOI

Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R,Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML,Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA,Wapenaar MC, Deloukas P, McGinnis R, McManus R*, Wijmenga C*, van Heel DA*., Newly identified genetic risk variants for celiac disease related to the immune response., Nature Genetics, 40, 2008, p395-402 Journal Article, 2008 DOI TARA - Full Text

Szabo de Edelenyi F, Goumidi L, Bertrais S, Phillips C, MacManus R, Roche H, Planells R, Lairon D., Prediction of the metabolic syndrome status based on dietary and genetic parameters, using Random Forest. , Genes and Nutrition, 3, (3-4), 2008, p173-176 Journal Article, 2008 DOI

White M, Mankan A, Lawless MW, O'Dwyer MJ, McManus R, Ryan T, Mortality in humans with pneumonia and sepsis is related to an uncompensated anti-inflammatory response to infection, Archives of Internal Medicine, 168, (13), 2008, p1468 - 1469 Journal Article, 2008 URL

O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T*. , The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression, Intensive Care Medicine, 34, (4), 2008, p683-691 Journal Article, 2008 DOI

Ryan, A.W., O'Brien, E., Shields, D., McManus, R., Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample , Atherosclerosis , 196, (1), 2008, 465-466 Journal Article, 2008 DOI

Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA,Todd JA, Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease, New England Journal of Medicine, 359, (26), 2008, p2767 - 2777 Journal Article, 2008 DOI

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, , A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21., Nature Genetics, 39, (7), 2007, p827 - 829 Journal Article, 2007 TARA - Full Text DOI

Azim K, McManus R, Brophy K, Ryan A, Kelleher D, Reynolds JV, Genetic Polymorphisms and the Risk of Infection Following Esophagectomy , Annals of Surgery, 246, (1), 2007, p122 - 128 Journal Article, 2007 DOI

Duggan E, O'Dwyer M, Caraher E, Diviney D, McGovern E, Kelleher D, McManus R, Ryan T, Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism, Anesthesia & Analgesia , 104, (6), 2007, p1343 - 1347 Journal Article, 2007 DOI TARA - Full Text

Zhao Y, Terron-Kwiatkowski A, Liao H, Lee SP, Allen MH, Hull PR, Campbell LE, Trembath RC, Capon F, Griffiths CE, Burden D, McManus R, Hughes R, Kirby B, Fitzgerald O, Kane D, Barker JN, Palmer CN, Irvine AD, McLean WHI , Filaggrin null alleles are not associated with psoriasis, Journal of Investigative Dermatology , 127, (8), 2007, p1878 - 1882 Journal Article, 2007 DOI

O'Dwyer MJ, Dempsey F, Crowley V, Kelleher DP, McManus R, Ryan T., Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study., Critical Care, 10, (5), 2006, pR139 Journal Article, 2006 DOI TARA - Full Text

Duggan E, Caraher E, Gately C, O'Dwyer M, McGovern E, Kelleher D, McManus R, Ryan T, Tumour necrosis factor alpha and Interleukin10 gene expression after cardiac surgery: The protective role of Interleukin 10, Critical Care Medicine , 34, (8), 2006, p2134 - 2139 Journal Article, 2006 DOI

Mattiangeli V, Ryan AW, McManus R, Bradley DG, A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population, Genome Biology, 7, (8), 2006, pR74- Journal Article, 2006 DOI

Mechanisms of steroid action and resistance in inflammatory bowel disease. in, editor(s)Jewell DP, Colombel, JF, Pena AS, Tromm A, Warren BS , Colitis: Diagnosis and Therapeutic Strategies, Falk Symposia, Kluwer Academic Publishers, 2006, pp87-97 , [Kelleher D, McManus R.] Book Chapter, 2006

O'Dwyer MJ, Mankan AK, Stordeur P, O'Connell B, Duggan E, White M, Kelleher DP, McManus R, Ryan T, The occurrence of severe sepsis is related to distinct patterns of cytokine gene expression, Shock, 26, (6), 2006, p544 - 550 Journal Article, 2006 DOI

Brophy K, Ryan AW, Thornton JM, Daly JS, McLoughlin R, O' Morain C, Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R, Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population., Genes and Immunity, 7, (1), 2006, p19 - 26 Journal Article, 2006 DOI

Ryan AW, Mapp J, Moyna S, Mattiangeli V, Kelleher D, Bradley DG, McManus R, Levels of inter-population differentiation among different functional classes of immunologically important genes, Genes and Immunity, 7, (2), 2006, p179 - 183 Journal Article, 2006 DOI

Ryan R*, Thornton J*, Duggan E, McGovern E, O'Dwyer MJ, Ryan AW, Kelleher D, McManus R, Ryan T, Gene polymorphism and requirement for vasopressor infusion after cardiac surgery, Annals of Thoracic Surgery, 82, (3), 2006, p895 - 901 Journal Article, 2006 DOI

O'Dwyer MJ, Dempsey F, Crowley V, Kelleher D, McManus R, Ryan T., Septic shock correlates with ADMA levels which may be influenced by a polymorphism in DDAH II: a prospective observational study, Critical Care, 10, (5), 2006, pR139 article number Journal Article, 2006 DOI

Phillips CP, Lopez-Miranda J, Perez-Jimenez F, McManus R & Roche HM, Genetic and Nutrient Determinants of the Metabolic Syndrome, Current Opinion in Cardiology , 2, (3), 2006, p185 - 193 Journal Article, 2006 DOI

Dring MM, Goulding CA, Trimble VI, Keegan D, Ryan AW, Brophy KM, Smyth CM, Keeling PWN, O'Donoghue D, O'Sullivan M, O'Morain C, Mahmud N, Wikström A-C, Kelleher D, McManus R., The Pregnane X Receptor Locus is Associated with susceptibility to inflammatory bowel disease., Gastroenterology, 130, (2), 2006, p341 - 348 Journal Article, 2006 DOI

Goulding C, McManus R, Murphy A, MacDonald GS, Barrett S, Crowe J, Hegarty J, McKiernan S, Kelleher D., The CCR5-delta32 Mutation- Impact on disease outcome in individuals with hepatitis C infection from a single source, Gut, 54, (8), 2005, p1157 - 1161 Journal Article, 2005 DOI

Ryan AW, Thornton JM, Brophy K, Daly JS, McLoughlin RM, O' Morain C, Abuzakouk M, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R., Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1., Tissue Antigens, 65, (2), 2005, p150 - 155 Journal Article, 2005 DOI

Windle HJ*, Ang YS*, Athie Morales V, McManus R*, Kelleher DP , Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals, Gut, 54, (1), 2005, p25 - 32 Journal Article, 2005 DOI TARA - Full Text

Goulding, C., Murphy, A., MacDonald, G., Barrett, S., Crowe, J., Hegarty, J., McKiernan, S., (...), McManus, R. , Erratum: The CCR5-Ä32 mutation: Impact on disease outcome in individuals with hepatitis C infection from a single source (Gut (August 2005) 54 (1157-1161)), 2005, - 1508 Miscellaneous, 2005 DOI

Kelly E, Sievers F, McManus R. , Haplotype frequency estimation error analysis in the presence of missing genotype data., BMC Bioinformatics, 5, (1), 2004, p188 - 203 Journal Article, 2004 DOI

Kelleher D, Farrell R, McManus R., Pharmacogenetics of inflammatory bowel disease., Novartis Foundation Symposium - Inflammatory Bowel Disease: Crossroads of Microbes, Epithelium and Immune Systems, edited by Derek Chadwick, Jamie Goode , 263, Novartis Foundation, 2004, pp41-53 Conference Paper, 2004 DOI

Arnott IDR, Nimmo ER, Drummond HE, Fennell J, Smith BR, MacKinlay E, Morecroft J, Anderson N, O'Sullivan M, O'Morain C, Kelleher D, McManus R, Satsangi J., NOD2/CARD15, TLR4 and CD14 Mutations in Scottish and Irish Patients with Crohn's disease: Evidence for Genetic Heterogeneity within Europe., Genes and Immunity, 5, (5), 2004, p417 - 425 Journal Article, 2004 DOI

Ryan AW, Thornton JM, Brophy K, Daly JS, O' Morain C, McLoughlin RM, Kennedy NP, Abuzakouk M, Stevens FM, Feighery C, Kelleher D, McManus R. , Haplotype variation at the IBD5 locus (5q31) in coeliac disease in the Irish population. , Tissue Antigens, 64, (2), 2004, p195 - 198 Journal Article, 2004 DOI

McManus R, Kelleher D , Celiac disease - the villain unmasked? (Invited commentary)., New England Journal of Medicine , 348, (25), 2003, p2573-2574 Journal Article, 2003 DOI

Ryan BM, Lefort L, McManus R, Daly J, Keeling PW, Weir DG, Kelleher D, A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up, Gut, 52, (1), 2003, p101-108 Journal Article, 2003 TARA - Full Text DOI

Dermot Kelleher, Henry Windle, William Byrne, Ross McManus, 'Helicobacter proteins and vaccines', European Patent Agency, US Patent Office, WO199601272, EP0769018 B1, US20070104731 A1, 2002 Patent, 2002 Other

Ryan BM, Molloy AM, McManus R, Arfin Q, Kelleher D, Scott JM, Weir DG. , The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: Role in tumor development and significance of allelic loss in tumor progression , International Journal of Gastrointestinal Cancer , 30, (3), 2001, p105 - 111 Journal Article, 2001 DOI

B. M. Ryan, R. McManus, J. S. Daly, E. Carton, P. W. Keeling, J. V. Reynolds and D. Kelleher, A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma, British Journal of Cancer, 85, (10), 2001, p1499-1503 Journal Article, 2001 DOI

Lakhani SR, Gusterson BA, Jacquemier J, Sloane JP, Anderson TJ, van de Vijver MJ, Farid LM, Venter D, Freeman A, Antoniou A, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, McManus R, Scherneck S, Ponder BAJ,. Futreal PA, Peto J, Stoppa-Lyonnet D, BignonY-J, Struewing JP, Bishop DT, Klijn JGM, Devilee P, Cornelisse CJ, Lasset C, Lenoir G, Barkardottir RB, Egilsson V, Hamann U, Chang-Claude J, Sobol H, Weber B, Easton DF, Stratton MR , The Pathology of Familial Breast Cancer: Histological Features of Cancers in Families not due to Mutations in BRCA1 or BRCA2 , Cliniical Cancer Research, 6, (3), 2000, p782 - 789 Journal Article, 2000 URL

Madrigal-Estebas, L., McManus, R., Byrne, B., Lynch, S., Doherty, D.G., Kelleher, D., O'Donoghue, D.P., (...), O'Farrelly, C. , Erratum: Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA transcripts: Implications for extrathymic T-cell differentiation (Human Immunology (1997) 58 (83)) , 2000, - 719 Miscellaneous, 2000 DOI

Ryan BM, McManus R, Daly JS, Keeling NWP, Weir DG, Lefort F, Kelleher D, Serum mutant K-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease, Annals of the New York Academy of Sciences, 906, 2000, p29-30 Journal Article, 2000 URL

Lakhani SR, Sloane JP, Gusterson BA, Anderson TJ, Jacquemier J, van de Vijver MJ, Farid LM, Venter D, Antoniou A, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, Mc Manus R, Scherneck S, Ponder BA, Ford D, Peto J, Stoppa-Lyonnet D, Stratton MR, Easton DF, et al. , Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations, Journal of the National Cancer Institute, 90, (15), 1998, p1138 - 1145 Journal Article, 1998 URL

Easton D, Steele L, Fields P, Ormiston W, Averill D, Daly PA, Mc Manus R, Neuhausen SL, Ford D, Wooster R, Cannon-Albright LA, Stratton MR, Goldgar DE, Cancer risks in two large breast cancer families linked to BRCA2 on chromosome 13q12-13, American Journal of Human Genetics, 61, (1), 1997, p120 - 128 Journal Article, 1997 URL

L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90 Journal Article, 1997 DOI

The Breast Cancer Linkage Consortium. (Lakhani SR, Sloane JP, Gusterson BA, Anderson TJ, Jacquemier J, van de Vijver MJ, Farid LM, Venter D, Storfer-Isser A, Smyth E, Steel CM, Haites N, Scott RJ, Goldgar D, Neuhausen S, Daly PA, Ormiston W, Mc Manus R, et al.), Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases, Lancet, 349, (9064), 1997, p1505 - 1510 Journal Article, 1997 DOI

R. McManus, A. G. Wilson, J. Mansfield, D. G. Weir, G. W. Duff and D. Kelleher, TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype, European Journal of Immunology, 26, (9), 1996, p2113-2118 Journal Article, 1996 URL DOI

R. McManus, M. Moloney, M. Borton, A. Finch, Y. T. Chuan, E. Lawlor, D. G. Weir and D. Kelleher, Association of celiac disease with microsatellite polymorphisms close to the tumor necrosis factor genes, Human Immunology, 45, (1), 1996, p24-31 Journal Article, 1996 URL DOI

S. Lynch, D. Kelleher, R. McManus and C. O'Farrelly, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation, European journal of immunology, 25, (5), 1995, p1143-1147 Journal Article, 1995 URL DOI

Collins N, Mc Manus R, Wooster R, Mangion J, Seal S, Lakhani SR, Ormiston W, Daly PA, Ford D, Easton DF, Stratton MR, Consistent loss of the wild type chromosome in breast cancers from BRCA2 gene carriers, Oncogene, 10, (8), 1995, p1673 - 1675 Journal Article, 1995

William Byrne, Dermot Kelleher, Ross McManus, Henry Windle, 'Helicobacter pylori antigenic protein preparation and immunoassays', European Patent Agency, WO1996001273 A1, EP19950922709, 1995 Patent, 1995 Other

Stratton MR, Ford D, Neuhasen S, Seal S, Wooster R, Friedman LS, King MC, Egilsson V, Devilee P, Mc Manus R, Daly PA, Smyth E, Ponder BAJ, Peto, J, Cannon- Albright L, Easton DF, Goldgar DE, Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q, Nature Genetics, 7, (1), 1994, p103 - 107 Journal Article, 1994 DOI

Wooster R, Neuhausen SL, Mangion J, Quirk Y, Ford D, Collins N, Nguyen K, Seal S, Tran T, Averill D, Fields P, Marshall G, Narod S, Lenoir GM, Lynch H, Feunteun J, Devilee P, Cornelisse CJ, Menko FH, Daly PA, Ormiston W, Mc Manus R, Pye C, Lewis CM, Cannon-Albright LA, Peto J, Ponder BAJ, Skolnick MH, Easton DF, Goldgar DE, Stratton MR, Localisation of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13, Science, 265, (5181), 1994, p2088 - 2090 Journal Article, 1994 DOI

Non-Peer-Reviewed Publications

Feighery CF, McManus R, Recent advances in the genetic understanding of coeliac disease, Proceedings of the Nutrition Society, 68, 2009, p1 - 5 Journal Article, 2009

Kelleher D, McManus R., Mechanisms of steroid action and resistance in inflammatory bowel disease , Falk Symposia, 2005 Journal Article, 2005

Kelleher D, Farrell R, McManus R, Pharmacogenetics of inflammatory bowel disease, in 'Inflammatory bowel disease - crossroads between microbes, epithelium and immune systems' , Novartis Foundation Symposium , 263, 2004 Journal Article, 2004

McManus R, Mechanisms of Steroid Action and Resistance in Inflammation and Disease., Journal of Endocrinology, 178, (1), 2003, p1-4 Journal Article, 2003 DOI

McManus R, Kelleher D. , Celiac disease - the villain unmasked? , New England Journal of Medicine, 348, 2003, p2573 - 2574 Journal Article, 2003

Research Expertise

Description

I am interested in the genetics/genomics of common diseases with an inflammatory component, particularly coeliac disease, inflammatory bowel disease and sepsis. We currently also have programmes into the genetic basis of psoriasis and oesophageal cancers in conjunction with collaborators nationwide and in Europe.

Projects

  • Title
    • Protecting the ICU - A prognostic test to predict clinical course and direct therapy in patients infected with SARS-COV2
  • Summary
    • SARS-COV2 infection is threatening acute hospital and intensive care unit capacity globally. There is an acute need for a prognostic test which will identify patients at either high or low risk of developing a severe response to COVID-19 infection. Such a test, by identifying whether the immune response is insufficient or excessive, could also help inform therapeutic options during disease progression, We have a long track-record of investigating immune parameters in hospitalised patients with infection and sepsis. We have previously identified a 6 cytokine signature upon admission that discriminates between patients who will experience an uneventful recovery compared to those who develop sepsis. We have also identified IL-7 as an indicator of severe disease in children with viral bronchiolitis and more recently described characteristic immune deficits in severe patients notably dominated by reduced effector T-lymphocyte differentiation. These findings indicate that defects in the immune response in the early stages of disease are strongly correlated with poor outcome. We propose to investigate patients with mild infection, severe infection and controls using a state-of-the art single cell transcriptomic analysis platform. This will allow us to identify a unique Immune response signature from different cells in patients that have mild vs those with a severe response to infection. This signature will be rapidly transformed into a simple flow cytometry or PCR based prognostic assay that can be run in hospital laboratories. This simple assay will identify individuals likely to develop a severe reaction to SARS-COV2 infection requiring ICU admission, but more importantly, will identify infected individuals that can be safely sent home to self- isolate freeing up critical hospital resources, decreasing costs and reducing the risk of viral spread. Importantly, it will also identify immune deficits in patients, informing evidence-based therapeutic options. This project can deliver a prognostic assay within 6 months.
  • Funding Agency
    • HRB
  • Date From
    • May 2020
  • Date To
    • Apr 2021
  • Title
    • Changing Landscapes in the Health and Life Sciences: Ethical Challenges of Big Data
  • Funding Agency
    • EU
  • Date From
    • Sept 2020
  • Date To
    • Aug 2023

Keywords

Autoimmunity; Chronic inflamation; Coeliac disease; GENE EXPRESSION ANALYSIS; GENE POLYMORPHISM; Genetic Analysis of Systemic Inflammatory Response Syndrome (SARS); Genetic Mapping, Gene Sequence; Genetics; Genetics of inflammatory disease; Genomes, Genomics; Genomic structure and function, molecular approaches to gene function; Inflammatory bowel disease; Molecular Genetics; PSORIASIS; SEPSIS

Recognition

Representations

Member of Molecular Medicine Ireland (MMI)/Clinical Research Development Ireland (CRDI) Education Committee 2003 - 2020

Council member, Irish Society of Human Genetics 2004 - 2008

Member, Scientific Committee, FINBAR, all-Ireland genetic epidemiology study of oesophageal cancer 2003 - 2009

Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics

Member of LIPGENE WP1.1. Genetic association study of candidate genes in the Metabolic Syndrome in a large French cohort. 2004 - 2009

Member of Eurolife Network of European Universities in the Life Sciences Steering Committee 2005 - 2015

Chairperson of Eurolife Joint Educational Programme in Translational and Experimental Medicine 2008 - 2013

Coordinator, Eurolife Network 2009 - 2011

Awards and Honours

Wellcome Trust / Health Research Board 'New Blood' Fellowship 1998

Fellow, Trinity College Dublin 2009

Science Foundation Ireland Principal Investigator 2010

Memberships

American Society of Human Genetics 2003 – present

Irish Society of Human Genetics 2001 – present

European Society of Human Genetics 2005 – present

Irish Society of Immunology 2008 – present