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Dr. David Hoey
Associate Professor, Mechanical, Manuf & Biomedical Eng


Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Biomedical Engineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.

Publications and Further Research Outputs

Peer-Reviewed Publications

Ahern DP, McDonnell JM, Riffault M, Evans S, Wagner SC, Vaccaro AR, Hoey DA, Butler JS., A meta-analysis of the diagnostic accuracy of hounsfield units on computed topography relative to dual-energy X-ray absorptiometry for the diagnosis of osteoporosis in the spine surgery population., The spine journal : official journal of the North American Spine Society, 2021 Journal Article, 2021 DOI TARA - Full Text

Johnson GP, Fair S, Hoey DA, Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling., Bone, 2021 Journal Article, 2021 TARA - Full Text

Geoghegan IP, McNamara LM, Hoey DA., Estrogen withdrawal alters cytoskeletal and primary ciliary dynamics resulting in increased Hedgehog and osteoclastogenic paracrine signalling in osteocytes., Scientific reports, 11, (1), 2021, p9272 Journal Article, 2021 DOI TARA - Full Text

Anushree Dwivedi, Patrick A. Kiely, David A. Hoey, Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism, Biochemical and Biophysical Research Communications, 534, 2021, p14--20 Journal Article, 2021 TARA - Full Text

Eichholz KF, Woods I, Riffault M, Johnson GP, Corrigan M, Lowry MC, Shen N, Labour M, Wynne K, O'Driscoll L, Hoey DA., Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles, Stem Cells Translational Medicine , 2020 Journal Article, 2020 DOI TARA - Full Text

Kian F. Eichholz and Stanislas Von Euw and Ross Burdis and Daniel J. Kelly and David A. Hoey, Development of a New Bone"Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating, Advanced Healthcare Materials, 2020, p2001102 Journal Article, 2020 TARA - Full Text

Mathieu Riffault, Gillian P Johnson, Madeline M Owen, Behzad Javaheri, Andrew A Pitsillides, David A Hoey, Loss of Adenylyl Cyclase 6 in Leptin Receptor"Expressing Stromal Cells Attenuates Loading"Induced Endosteal Bone Formation, JBMR Plus, 2020 Journal Article, 2020 TARA - Full Text

Parmentier L, Riffault M, Hoey DA., Utilizing Osteocyte Derived Factors to Enhance Cell Viability and Osteogenic Matrix Deposition within IPN Hydrogels., Materials (Basel, Switzerland), 13, (7), 2020 Journal Article, 2020 DOI TARA - Full Text

Geoghegan IP, Hoey DA, McNamara LM., Integrins in Osteocyte Biology and Mechanotransduction., Current osteoporosis reports, 17, (4), 2019, p195-206 Journal Article, 2019 DOI

Kian F. Eichholz, Ian Woods, Gillian P. Johnson, Nian Shen, Michele Corrigan, Marie-Noelle Labour, Kieran Wynne, Michelle C. Lowry, Lorraine O"Driscoll, David A. Hoey, Human bone marrow mesenchymal stem/stromal cell behaviour is coordinated via mechanically activated osteocyte-derived extracellular vesicles, 2019 Journal Article, 2019

M. A. Corrigan, T. M. Ferradaes, M. Riffault, D. A. Hoey, Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study, Cellular and Molecular Bioengineering, 12, (1), 2019, p53--67 Journal Article, 2019 TARA - Full Text

Stavenschi E, Hoey DA., Pressure-induced mesenchymal stem cell osteogenesis is dependent on intermediate filament remodeling., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33, (3), 2019, p4178-4187 Journal Article, 2019 TARA - Full Text DOI

Geoghegan IP, Hoey DA, McNamara LM., Estrogen deficiency impairs integrin "vß3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling., Scientific reports, 9, (1), 2019, p4654 Journal Article, 2019 DOI TARA - Full Text

Brennan CM, Eichholz KF, Hoey DA., The effect of pore size within fibrous scaffolds fabricated using melt electrowriting on human bone marrow stem cell osteogenesis., Biomedical materials (Bristol, England), 14, (6), 2019, p065016 Journal Article, 2019 TARA - Full Text DOI

Corrigan MA, Coyle S, Eichholz KF, Riffault M, Lenehan B, Hoey DA., Aged Osteoporotic Bone Marrow Stromal Cells Demonstrate Defective Recruitment, Mechanosensitivity, and Matrix Deposition., Cells, tissues, organs, 207, (2), 2019, p83-96 Journal Article, 2019 DOI

Kian F. Eichholz, David A. Hoey, Melt electrowritten scaffolds with bone-inspired fibrous and mineral architectures to enhance BMP2 delivery and human MSC osteogenesis, 2019 Journal Article, 2019

Eichholz KF, Hoey DA, Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing., Acta biomaterialia, 2018 Journal Article, 2018 TARA - Full Text

Michele A. Corrigan, Gillian P. Johnson, Elena Stavenschi, Mathieu Riffault, Marie-Noelle Labour, David A. Hoey, TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium, Scientific Reports, 8, (1), 2018 Journal Article, 2018 TARA - Full Text

Marie-Noelle Labour, Marina Walsh, Marie Cavaignac, Kian Eichholz, Eamonn deBarra, David A. Hoey, Electrospun Poly-D-L-lactic acid fibrous scaffolds as a delivery vehicle for calcium phosphate salts to promote in situ mineralisation and bone regeneration, Journal of Biomaterials and Tissue Enginering, 8, 2018, p1 - 12 Journal Article, 2018 TARA - Full Text

Elena Stavenschi, Michele A. Corrigan, Gillian P. Johnson, Mathieu Riffault, David A. Hoey, Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study, Stem Cell Research & Therapy, 9, (1), 2018 Journal Article, 2018

Gillian P. Johnson, Elena Stavenschi, Kian F. Eichholz, Michele A. Corrigan, Sean Fair, David A. Hoey, Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium, Journal of Cell Science, 2018, pjcs.222737 Journal Article, 2018 TARA - Full Text

Agarwal S, Labour MN, Hoey D, Duffy B, Curtin J, Jaiswal S, Enhanced corrosion resistance and cytocompatibility of biomimetic hyaluronic acid functionalised silane coating on AZ31 Mg alloy for orthopaedic applications., Journal of materials science. Materials in medicine, 2018 Journal Article, 2018 TARA - Full Text

Kelly NP, Flood HD, Hoey DA, Kiely PA, Giri SK, Coffey JC, Walsh MT, Direct mechanical characterization of prostate tissue-a systematic review., The Prostate, 2018 Journal Article, 2018 TARA - Full Text

Sankalp Agarwal, Mathieu Riffault, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal, Biomimetic Hyaluronic Acid-Lysozyme Composite Coating on AZ31 Mg Alloy with Combined Antibacterial and Osteoinductive Activities, ACS Biomaterials Science & Engineering, 3, (12), 2017, p3244--3253 Journal Article, 2017 TARA - Full Text

Johnson, G.P., English, A.-M., Cronin, S., Hoey, D.A., Meade, K.G., Fair, S., Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine, Biology of Reproduction, 97, (2), 2017, p302-312 Journal Article, 2017 TARA - Full Text

Stavenschi, E., Labour, M.-N., Hoey, D.A., Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration, Journal of Biomechanics, 55, 2017, p99-106 Journal Article, 2017

Flanagan AM, Stavenschi E, Basavaraju S, Gaboriau D, Hoey DA, Morrison CG, Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification., 2017 Journal Article, 2017

Labour MN, Riffault M, Christensen ST, Hoey DA, TGFß1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner., 2016 Journal Article, 2016 TARA - Full Text

Eichholz, K.F., Hoey, D.A., The Role of the Primary Cilium in Cellular Mechanotransduction: An Emerging Therapeutic Target, Mechanobiology: Exploitation for Medical Benefit, 2016, p61-73 Journal Article, 2016

O'Connor Mooney R, Davis NF, Hoey D, Hogan L, McGloughlin TM, Walsh MT, On the Automatic Decellularisation of Porcine Aortae: A Repeatability Study Using a Non-Enzymatic Approach., 2016 Journal Article, 2016

Coyle, S., Lenehan, B., Hoey, D.A., Electromechanics of bone: Mechanobiological considerations, Electrically Active Materials for Medical Devices, 2016, p511-528 Journal Article, 2016

Corrigan M, Lee K, Labour M, Jacobs C, Hoey D, Fluid flow-induced bending of the primary cilium triggers a distinct intraciliary calcium flux in mesenchymal stem cells., 2015 Journal Article, 2015

Chen JC, Hoey DA, Chua M, Bellon R, Jacobs CR, Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015 Journal Article, 2015 TARA - Full Text DOI

Labour M, Christensen S, Hoey D, TGFß1 Signalling in human mesenchymal stem cells is regulated by the primary cilium., 2015 Journal Article, 2015

Brady RT, O'Brien FJ, Hoey DA, Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation., Biochemical and biophysical research communications, 459, (1), 2015, p118 - 123 Journal Article, 2015 TARA - Full Text

Browne L., O'Callaghan S., Hoey D., Griffin P., McGloughlin T., Walsh M., Correlation of Hemodynamic Parameters to Endothelial Cell Proliferation in an End to Side Anastomosis, Cardiovascular Engineering and Technology, 5, (1), 2014, p110 - 118 Journal Article, 2014 DOI

Espinha L., Espinha L., Hoey D., Hoey D., Fernandes P., Rodrigues H., Jacobs C., Oscillatory fluid flow influences primary cilia and microtubule mechanics, Cytoskeleton, 71, (7), 2014, p435 - 445 Journal Article, 2014 DOI TARA - Full Text

Downs M., Nguyen A., Herzog F., Hoey D., Hoey D., Hoey D., Jacobs C., An experimental and computational analysis of primary cilia deflection under fluid flow, Computer Methods in Biomechanics and Biomedical Engineering, 17, (1), 2014, p2 - 10 Journal Article, 2014 DOI

Lee K., Hoey D., Hoey D., Hoey D., Spasic M., Spasic M., Tang T., Tang T., Hammond H., Hammond H., Jacobs C., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo, FASEB Journal, 28, (3), 2014, p1157 - 1165 Journal Article, 2014 DOI

Hoey, D.A., Downs, M.E., Jacobs, C.R., The mechanics of the primary cilium: An intricate structure with complex function, Journal of Biomechanics, 45, (1), 2012, p17-26 Journal Article, 2012

Hoey D., Hoey D., Hoey D., Tormey S., Ramcharan S., O'Brien F., O'Brien F., Jacobs C., Primary cilia-mediated mechanotransduction in human mesenchymal stem cells, Stem Cells, 30, (11), 2012, p2561-2570 Journal Article, 2012 DOI

Hoey D., Hoey D., Hoey D., Chen J., Jacobs C., The primary cilium as a novel extracellular sensor in bone, Frontiers in Endocrinology, 3, (JUN), 2012 Journal Article, 2012 DOI

Jacobs C, Downs M, Nguyen A, Herzog F, Hoey D, Mechanical behavior of primary cilia., 2012 Journal Article, 2012

Hoey, D.A., Jacobs, C.R., Oscillatory fluid flow affects the osteogenic differentiation of human bone marrow stromal cells in a primary cilium dependent manner, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p331-332 Journal Article, 2011

Hoey, D.A., Kelly, D.J., Jacobs, C.R., A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 412, (1), 2011, p182-187 Journal Article, 2011 TARA - Full Text

Grande D., Shah N., Catanzano A., Nelson F., Hoey D., Hoey D., Jacobs C., On the horizon from the ORS, Journal of the American Academy of Orthopaedic Surgeons, 19, (1), 2011, p59-62 Journal Article, 2011

Hoey D and Taylor D, The effect of mixing technique on fatigue of bone cement when stress concentrations are present., International Journal of Nano and Biomaterials, 3, 2010, p36 - 48 Journal Article, 2010 DOI

Lee, K.L., Hoey, D.A., Jacobs, C.R., Primary cilia-mediated mechanotransduction in bone, Clinical Reviews in Bone and Mineral Metabolism, 8, (4), 2010, p201-212 Journal Article, 2010

Herzog, F.A., Geraedts, J., Hoey, D., Jacobs, C.R., A mathematical approach to study the bending behavior of the primary cilium, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010, 2010 Journal Article, 2010

Hoey D and Taylor D, Quantitative analysis of the effect of porosity on the fatigue strength of bone cement., Acta Biomaterialia, 5, 2009, p719 - 726 Journal Article, 2009 DOI

Hoey D and Taylor D, Statistical distribution of the fatigue strength of porous bone cement. , Biomaterials, 30, 2009, p6309 - 6317 Journal Article, 2009 DOI

Hoey, D., Carette, D., O'Reilly, P., Taylor, D., The role of stress concentrations in the bone cement mantle, Proceedings of the ASME Summer Bioengineering Conference, SBC2008, (PART A), 2009, p463-464 Journal Article, 2009

Hoey D and Taylor D, Comparison of the fatigue behaviour of two different forms of PMMA, Fatigue and Fracture of Engineering Materials and Structures, 32, 2009, p261 - 269 Journal Article, 2009 DOI

Taylor D and Hoey D, High cycle fatigue of welded joints: the TCD experience, International Journal of Fatigue, 31, 2009, p20 - 27 Journal Article, 2009 DOI

Hoey D and Taylor D , Fatigue in porous PMMA: the effect of stress concentrations, International Journal of Fatigue, 30, 2008, p989 - 995 Journal Article, 2008

Hoey, D., O'Reilly, P., Taylor, D., Fatigue in PMMA: The effect of notches and pores predicted using the TCD, 17th European Conference on Fracture 2008: Multilevel Approach to Fracture of Materials, Components and Structures, 2, 2008, p1570-1575 Journal Article, 2008

Taylor, D., Hoey, D., Sanz, L., O'Reilly, P., Fracture and fatigue of bone and bone cement: The critical distance approach, Fracture of Nano and Engineering Materials and Structures - Proceedings of the 16th European Conference of Fracture, 2006, p1025-1026 Journal Article, 2006

Research Expertise


Orthopaedic Biomechanics and Mechanobiology Mechanotransduction mechanisms Biomaterials Primary Cilia Extracellular Vesicles/Exosomes


  • Title
    • Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
  • Summary
    • Every 30 seconds a person suffers an osteoporosis-related bone fracture in the EU, resulting in significant morbidity, mortality, and health-care costs estimated at €36 billion annually. Current therapeutics target bone resorbing osteoclasts, but these are associated with severe side effects. Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs sense and respond to changes in their mechanical environment are virtually unknown. Primary cilia are nearly ubiquitous 'antennae-like' cellular organelles that have very recently emerged as extracellular mechano/chemo-sensors and thus, are strong candidates to play an important role in regulating MSC responses in bone. However, to date, research on the stem cell primary cilium is almost non-existent. Therefore, the objective of this research program is to determine the role of the understudied primary cilium and associated molecular components in the osteogenic differentiation and recruitment of human MSCs in loading-induced bone adaptation. This will be achieved through ground breaking in vitro and in vivo techniques developed by the applicant. The knowledge generated in this proposal will represent a profound advance in our understanding of stem cell mechanobiology. In particular, the identification of the cilium and associated molecules as central to stem cell behaviour will lead to the direct manipulation of MSCs via novel cilia-targeted therapeutics that mimic the regenerative influence of loading at a molecular level. These novel therapeutics would therefore target bone formation rather than resorption, providing an innovative alternative path to treatment, resulting in an improved supply of bone forming cells, preventing osteoporosis. Furthermore, these novel therapeutics will be incorporated into biomaterials generating novel bioactive osteoinductive scaffolds. These advances will not only improve quality of life for the patient but will significantly reduce the financial burden of bone loss diseases in the EU.
  • Funding Agency
    • European Research Council
  • Date From
    • 01/11/2013
  • Date To
    • 31/10/2018
  • Title
    • Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis
  • Summary
    • Every 30 seconds a person suffers an osteoporosis-related bone fracture, resulting in significant morbidity, mortality, and health-care costs estimated at 36billion euro annually. Current therapeutics target osteoclasts but are associated with severe side effects. Osteoporosis arises when stem cells (MSCs) fail to produce sufficient numbers of osteoblasts. A key regulator of MSC behaviour is loading, yet the mechanisms by which MSCs proliferate, differentiate and are recruited to sites of loading to replace exhausted osteoblasts remain elusive. Osteocytes are ideally numbered and positioned to be sensors and regulators of bone formation. However research on osteocyte-MSC signalling is almost non-existent. Therefore the objective of this research project is to determine the role of the osteocyte and associated signalling mechanisms in regulating MSC contributions to bone formation and to develop novel 'Bone-on-a-Chip' microfluidic platforms for the validation of novel anabolic therapeutics for osteoporosis.
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2014
  • Date To
    • 2018




Awards and Honours

Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz) 2016

Marie-Skłodowska Curie COFUND Excellence award 2015

University of Limerick Award for Research Excellence (Early Career) 2014

European Research Council Starting Grant 2013


Engineers Ireland (Treasurer of the Biomedical Division) 2006 – present

Orthopedic Research Society 2010 – present

Marie-Curie Fellow Association 2015 – present