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Trinity College Dublin, The University of Dublin

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Hoey Lab

Our research focus is to integrate engineering mechanics into the understanding of the molecular basis of musculoskeletal physiology and disease. Our research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, we are focused on determining indirect and direct biophysical regulation of skeletal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new orthobiologics and biomaterials that mimic the beneficial effect of biophysical stimuli and treat large bone defects and orthopaedic diseases such as osteoporosis.