b"Strategic Plan 2020 255 Childrens Brain Healthof over 2,000 individuals from early adolescence. Childrens Jane McGrathand Robert Whelanare establishing aBrain Health longitudinal cohort of children (beginning at age 10)investigation with a diagnosis of ADHD.The groups ofAndrewat TCIN. Harkin, Shane O'MaraandMarina Lynch are analyzingbiochemical, cognitive and behavioural mechanismsand markers altered in depression, stress, and autismin collaboration with clinical PIs Veronica OKeane &Declan McLoughlinand neuroimunology PIsKingstonMills & Colm Cunningham. At an even more basic level,groups are analysing processes of direct relevance tochildrens health. Mani Ramaswamisgroup isanalysing the mechanisms that form inhibitory masksTCIN will engage with the Trinity Research in for familiar stimuli and consolidated memories thatChildhood Centre (TRiCC) on Childrens brain health may be relevant to phenomena such as stimulusresearch with the aim of developing research hypersensitivity, novelty aversion and intrusiveproposals supported by external networks and memory sometime seem in autism and otherfunding bodies. There is also potential for research psychiatric disorders. Tomas Ryansgroupsynergies with the National Childrens Hospital. manipulates memory engram cells duringEvents in the brain that occur during development, development, to separate and analyse memoryfrom in utero through childhood and adolescence, storage and recall processes in mice, which has directshape thoughts, emotions, and behaviour in relevance to our understanding of the phenomenonadulthood. Therefore, to better understand mental of infantile amnesia.health diiculties and to improve treatments formental health conditions, it is important to study the More generally, TCIN houses broad expertise anddeveloping brain. TCIN binds together several interest in understanding, measuring andresearch programmes connecting fundamental, manipulating neural processes ranging from sensoryclinical and translational studies of childrens brain perception and motor coordination, to arousal,health.Intensive collaborative research focuses on attention and decision making in addition to a focusthe genetics, biology and mechanisms of childhood on childhood vision and blindness. These strengths inpsychosis, autism, attention deficit hyperactivity sensory and cognitive psychology as well as neuraldisorder (ADHD), depression and substance abuse.engineering support diverse approaches tounderstanding and managing sensory, cognitive andThis includes work with developing human patient motor capabilities in children.cohorts as well as translational eorts using animaland cellular models, led by a number of clinicianscientists, including Louise Gallagher, Mary Cannon,Jane McGrath, Veronica OKeaneand DeclanMcLoughlinas well as cognitive neuroscientists andneurophysiologists, including Clare Kellyand ClaireGillan. In TCIN, these programmes intersect withbottom up approaches driven by non-clinical PIs. For example, Rhodri Cusacksgroup leads a majorinitiative using brain imaging and artificialintelligence to characterise the emergence ofcognition, with strong clinical collaborations.Arun Bokdeand Robert Whelanare principalinvestigators on a longitudinal neuroimaging study of development (IMAGEN) that is following a cohort Child Brain Health- a major societal issue4"