b'3 NeurodegenerationMechanisms & InterventionsNeurodegeneration refers to damage or loss of brainneurons, which dont normally reproduce or repairthemselves, leading to progressive, incurable anddebilitating conditions associated with adeterioration of mental functioning, movement andemotional wellbeing. Many neurodegenerativediseases are associated with age.Given that 25% ofthe population of Europe is estimated to be over 65by 2030, the need to confront the growing challengeof brain degenerative disorders has never beengreater. Researchers in this thematic area are combiningexpertise to address the genetic and biologicalmechanisms that trigger neurodegeneration, causeneurons to die or promote a loss of connectionsbetween neuronal cells in the brain. There is a largefocus on the contribution of inflammatory-likeprocesses in the brain to the development ofneurodegeneration. Researchers are engaged in theidentification of biomarkers and the development ofneuroprotective strategies based on analysis ofmolecular mechanisms and advanced simultaneousfunctional MRI/electroencephalogram (fMRI/EEG) andelectrophysiological analyses. Furthermore, researchon the development of novel behavioural and brainstimulation methods that can be integrated with Interventions inpharmaceutical therapies to delay cognitive decline Neurodegenerationand promote brain resilience is ongoing.Hippocampul Cytoarchitecure1'