|8th Dec 2017||Seminar by Prof. Gero Miesenböck FRS from the Centre for Neural Circuits an Behaviour, Oxford University:
This Friday we will have a very special seminar at 11am in the Smurfit Atrium. (*Note the change of time).
Gero Miesenböck FRS is being conferred an Honorary Degree - Doctor in Science (honoris causa) by Trinity College on Friday and has kindly agreed to speak to the students, researchers and staff on his pioneering work (https://en.wikipedia.org/wiki/Gero_Miesenböck [en.wikipedia.org]). All teaching in the Smurfit Institute of Genetics is cancelled from 11am-12pm to allow staff and students attend this special seminar.
The title of his seminar will be: ‘Optogenetics’.
Special notes on this week’s speaker, Professor Gero Miesenböck:
Gero Miesenböck pioneered the science of optogenetics for which there will be Nobel Prize awarded in coming years. He established the principles of optogenetic control in 2002, using light to activate normally light-insensitive neurons and thereby allow remote control animal behaviour. Optogenetics, by allowing identified neurons to be selectively activated or silenced by light, has revolutionized our ability to understand and dissect brain circuits.
Miesenböck has exploited optogenetics in a succession of brilliant experiments illuminating synaptic connectivity, the neural basis of reward, mechanisms of sleep homeostasis and the control of sexually dimorphic circuitry. These incisive analyses have demonstrated the full potential of optogenetics beyond the proof-of-principle stage, providing a tool for the treatment of acute Parkinsonism, depression and other neurological conditions.
He has received several individual awards for his work (FRS, the William Exner Medal, the Heinrich Wieland Prize) and shared several major prizes (E.g. The Brain Prize, The Jakob Heskay Gabbay Award, the BBVA Foundation Frontiers of Knowledge Award, The Massry Prize) with one or more of among Ernst Bamberg, Edward Boyden, Karl Deisseroth, Peter Hegemann, and Georg Nagel, who are the others on the short list for the Optogenetics Nobel Prize.
|24th Nov 2017||Seminar by Prof. Corrado Santocanale from the Centre for Chromosome Biology, NUI Galway:
Blocking DNA replication before it starts: insights on CDC7 kinase functions and inhibitors by chemical genetics approaches
|3rd Nov 2017||Seminar by Dr. Elaine Dunleavy from the Centre for Chromosome Biology, NUIG, Galway:
Centromere Dynamics in Drosophila Germ Cells
|20th Oct 2017||Seminar by Dr. Michalis Averof from the Institut de Génomique Fonctionnelle de Lyon (IGFL), France:
Old questions, new models: probing the cellular basis of leg regeneration in a crustacean
|28th Apr 2017||Seminar by Prof. David MacHugh from the UCD School of Agriculture and Food Science:
Population Genomics of Extinct and Modern Cattle Populations
|21st Apr 2017||Seminar by Prof. Tatiana Kutateladze from the University of Colorado, USA:
Molecular mechanisms of epigenetic regulation
|6th Apr 2017||Seminar by Dr. Colin Adrain from the Instituto Gulbenkian de Ciência, Lisbon, Portugal:
iRhoms: key regulators of inflammation, growth factor signaling, and metabolism
|31st Mar 2017||Seminar by Prof. Luciano Di Croce from the Centre for Genomic Regulation (CRG), Barcelona, Spain:
Epigenetic regulation of stem cell differentiation
|24th Mar 2017||Seminar by Dr. Robert Kelly from the Developmental Biology Institute, Aix Marseille Universite, France:
The DiGeorge syndrome gene Tbx1 and the link between heart and head muscle development
|10th Mar 2017||Seminar by Prof. Savvas Savvides from the Inflammation Research Center at the VIB, Belgium:
Structure, Mechanism and Antagonism of protein complexes pivotal to Th2 immunity in allergy and asthma
|3rd Mar 2017||Seminar by Prof. Alexandre Reymond from the Center for Integrative Genomics, University of Lausanne:
Genome Architecture: for better and for worse
|3rd Feb 2017||Seminar by Prof. Britta Engelhardt from the University of Bern:
The brain barriers shape the immune privilege of the CNS
|27th Jan 2017||Seminar by Dr. Justin Goodrich from the University of Edinburgh:
Poacher turned gamekeeper? New roles for transposases in plant epigenetic machinery.
|28th Oct 2016||Seminar by Prof. Neil Brockdorff from the Department of Biochemistry, University of Oxford:
Gene silencing mechanisms in X chromosome inactivation
|21th Oct 2016||Seminar by Prof. Roland Schuele from the University Freiburg Medical Center:
LSD1 controls chromosomal stability and metabolic reprogramming
|11th Mar 2016||Seminar by Prof. Mark Jobling from the University of Leicester:
Beyond the testicle: the Y chromosome in human evolutionary genetics
|19th Feb 2016||Seminar by Prof. Martin Hegner from CRANN and the School of Physics:
Following ribosomal translation and protein folding one molecule at the time
|16th Feb 2016 at 6 pm||Public lecture by Vishva Dixit M.D. (Dawson Prize recipient):
Cancer Therapy: Past, Present and Future (Stanley Quek Theatre, Trinity Biosciences Institute, Pearse Street)
|5th Feb 2016||Seminar by Prof. Ulrich Dirnagl from Charité Universitätsmedizin, Berlin:
Lost or found in translation? Lessons from the stroke experience
|27th Jan 2016||Seminar by Prof. Paul Sharp from the Institute of Biology, Edinburgh University:
Origins and evolution of human malaria parasites
|22nd Jan 2016||Seminar by Prof. Song Tan from the Pennsylvania State University:
Recognition of the nucleosome by chromatin factors and enzymes
|27th Nov 2015||Seminar by Eppie Jones from the Bradley group:
Ancient DNA and Genetic History of Europeans
|06th Nov 2015||Seminar by Dr. Shaun Cowley from the University of Leicester:
Histone Deacetylase (HDAC) 1 and 2 are essential for pluripotency and cell division in mouse embryonic stem cells
|30th Oct 2015||Seminar by Prof. Damir Janigro from the Cleveland Clinic:
Blood-brain barrier and immunity in concussions
|16th Oct 2015||Seminar by Dr. Raphaël Margueron from the Institut Curie, Paris:
Polycomb complex PRC2: Mechanisms of action and roles in diseases
|Fri, 09/10/15||Seminar by Dr. Sara Farrona from NUI Galway:
Identification of novel components of the Polycomb Group pathway in Arabidopsis
Adrian Bracken has invited Dr. Sara Farrona from NUI Galway to give a seminar Friday 9th October 1:00pm in The Smurfit Atrium (please note the time).
The title of her seminar will be: 'Identification of novel components of the Polycomb Group pathway in Arabidopsis'.
Sara is a plant geneticist who studies the function chromatin regulators. During her PhD she studied the function ofBRM, a protein involved in chromatin remodeling that has an important role in plant development. This research showed her that flowering, one of the major developmental processes of plants, is a wonderful model to extend her studies on chromatin regulation. After her PhD, she continued this line of research in her postdoctorate and now as a newly established principal investigator in NUI Galway.
Post-fertilization expression of FLOWERING LOCUS T suppresses reproductive reversion.
Development-related PcG target in the apex 4 controls leaf margin architecture in Arabidopsis thaliana.
CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II.
Tissue-specific expression of FLOWERING LOCUS T in Arabidopsis is maintained independently of polycomb group protein repression.
Brahma is required for proper expression of the floral repressor FLC in Arabidopsis.
cis-Regulatory elements and chromatin state coordinately control temporal and spatial expression of FLOWERING LOCUS T in Arabidopsis.
CHD3 proteins and polycomb group proteins antagonistically determine cell identity in Arabidopsis.
PEP1 regulates perennial flowering in Arabis alpina.
The impact of chromatin regulation on the floral transition.
A nucleosome interaction module is required for normal function of Arabidopsis thaliana BRAHMA.
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27.
FT protein movement contributes to long-distance signaling in floral induction of Arabidopsis.
The putative SWI/SNF complex subunit BRAHMA activates flower homeotic genes in Arabidopsis thaliana.
The Arabidopsis thaliana SNF2 homolog AtBRM controls shoot development and flowering. Farrona S, Hurtado L, Bowman JL, Reyes JC.
|Thu, 01/10/15||Seminar by Dr. Denis Jabaudon from the University of Geneva:
Becoming a new neuron in the cerebral cortex
Kevin Mitchell has invited Dr. Denis Jabaudon from the University of Geneva to give a seminar on Thursday at 2:00pm in The Smurfit Atrium (please note the time).
The title of his seminar will be: 'Becoming a new neuron in the cerebral cortex'.
Denis is a leading researcher in developmental neurobiology and is interested in the mechanisms of specification of neuronal cell fates in the developing brain. In particular, his group has elucidated some of the mechanisms by which incoming axons from thalamus to cortex (or retina to thalamus) instruct the cellular identity of neurons in the recipient areas. This ongoing interplay between cell fates and connectivity patterns is a fundamental process in the self-assembly and refinement of the brain's circuitry.
Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons.
Retinal input directs the recruitment of inhibitory interneurons into thalamic visual circuits.
In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.
|9th May 2015||Surfing the Waves of Genetics at Trinity: A celebration to mark the retirement of David McConnell|
|6th-9th July 2015||Conference: 11th International Conference on Cerebral Vascular Biology, Cité Internationale Universitaire, Paris - France|
|Fri, 25/04/14||Seminar by Prof Anna Di Rienzo from the University of Chicago, USA:
Genetic adaptations to local environments in human populations
|Fri, 11/04/14||Seminar by Prof. Thomas Ferguson from Washington University, USA:
Autophagy and phagocytosis converge for better vision
|Fri, 04/04/14||Seminar by Prof. Ingolf Blasig from the FMP Institute, Berlin:
Peptidomimetics of tight junction proteins - effects on neurological barriers
|Fri, 28/03/14||Seminar by Prof. Mark Lawler (Queen's University Belfast):
Improving outcomes for our cancer patients; time to get personal
|Fri, 07/03/14||Seminar by Prof. Kristian Helin (University of Copenhagen):|
Epigenetic regulation of cell identity and transcription
The major focus of the research in Prof. Helin?s laboratory is to elucidate the molecular mechanisms leading to cancer and to transform this knowledge into novel anti-cancer therapies. This research has led to the identification of novel mechanisms for the control of stem cell self-renewal and differentiation, the identification of novel enzymatic activities regulating histone methylation, and to important new insights into how cancer develops. Moreover the discoveries have led to the foundation of the biotech company EpiTherapeutics that develops small molecule inhibitors for the future treatment of cancer patients.
shRNA screening identifies JMJD1C as being required for leukemia maintenance.
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3.
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation.
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
A model for transmission of the H3K27me3 epigenetic mark.
Functional interaction between the RBP2 H3K4 demethylase and the Polycomb Repressive Complex 2.
UTX and JMJD3 are H3K27 demethylases involved in HOX gene regulation and development.
The Polycomb group proteins bind throughout the INK4A-ARF locus and are dissociated in senescent cells.
RBP2 belongs to a family of demethylases specific for tri- and di-methylated lysine 4 on Histone 3.
Genome-wide mapping of Polycomb target genes unravels their role in cell-fate transitions.
The putative oncogene GASC1/JMJD2c demethylates tri- and di-methylated lysine 9 on histone H3.
|Fri, 28/02/14||Seminar by Prof. Laurence Hurst (University of Bath):|
Why there is more to gene evolution than protein function: splicing and dual-coding sequence
Abstract of Talk:
There is considerable variation in the rate at which different genes evolve. Why is this? Classically it has been considered that the density of functionally important sites must predict rates of protein evolution. Likewise, amino acid choice is usually assumed to reflect optimal protein function and codon choice is random. Here I present evidence suggesting that this view is too simplistic. In particular I concentrate on how selection acting during the protein's production history can also affect gene evolutionary rates as well as amino acid and codon choice. Exploring the role of selection at the RNA level, I specifically address how the need to specify exonic splice enhancer motifs in pre-mRNA impacts amino acid choice, codon choice and rates of evolution at both synonymous and non-synonymous sites. Moreover, I show, in opposition to the nearly neutral theory of molecular evolution, that as regards splicing, selection is stronger, not weaker, when population sizes are small.
Laurence Hurst is the Professor of Evolutionary Genetics in the Department of Biology and Biochemistry at The University of Bath. His research interests cover a broad span of evolution, genetics and genomics. His group dominantly uses computational and mathematical techniques to understand the way genes and genomes evolve. He is especially interested in understanding whether selection might operate on what have commonly been assumed to be unimportant mutations (e.g. synonymous mutations, small genome re-arrangements) and if so why. This has relevance for diagnosis of genetic diseases, as well as for gene and genome manipulation (for health, food or research).
Laurence is widely considered as one of the international leaders in molecular evolution research. His impressive publication record includes 24 papers in Nature and Nature family (Nat Genet etc.), 3 Science papers and 13 PLoS papers. A full list is available here: http://people.bath.ac.uk/bssldh/LaurenceDHurst/Publications.html
|Fri, 14/02/14||Seminar by Prof. Judith Mank (UCL)
The Evolution of Sexual Dimorphism: Linking intra-sexual transcriptional and phenotypic variation
|Fri, 07/02/14||Seminar by James Keaney from Matt Campbell's lab and Ian Richardson from Dan Bradley's lab.
|Fri, 31/01/14||Seminar by Dr. Jackie Dolan from Kevin Mitchell's lab and Dr. Natalie Hudson from Matt Campbell's.
|Fri, 24/01/14||Seminar by Prof. Haruhiko Koseki (RIKEN Center for Allergy and Immunology in Yokohama, Japan):|
Polycomb Silencing in Mammalian Development
Adrian Bracken has invited Prof. Haruhiko Koseki a developmental geneticist from the RIKEN Center for Allergy and Immunology in Yokohama, Japan to give a seminar on Friday at 1:00 pm in the Smurfit Atrium.
The title of his seminar will be "Polycomb Silencing in Mammalian Development".
Haruhiko Koseki is Director of the Developmental Genetics Research Group at the RIKEN Research Center for Allergy and Immunology in Yokohama, where he studies the epigenetic regulation of Polycomb group genes in development. He recently joined the journal Development as an Editor. The goal of Dr. Koseki's research is to understand how cellular phenotypes can be stably retained through development irrespective of environmental cues in some situations, while being altered in response to external signals in others. His work also focuses on how these epigenetic mechanisms control morphogenesis and tissue homeostasis. Towards this end, his lab combines mouse genetics, genomic and imaging approaches to study how chromatin modifications regulate stem cell identities, meiosis, patterning and organ development.
Areas of expertise:
Mouse genetics, epigenetics, patterning, meiosis, ES cells, axial specifications
Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.
SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.
HP1 links histone methylation marks to meiotic synapsis in mice.
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.
FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.
Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.
Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.
Topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.
|Thu, 05/12/13||Research Seminar at 4 p.m. in LB01, Lloyd Institute by Prof. Elliot M. Meyerowitz (California Institute of Technology):
Physical as well as Chemical Signals Control Plant Morphogenesis
|Wed, 04/12/13||Public Talk at 6 p.m. in the Stanley Quek Theatre, Trinity Bioscience Institute by Prof. Elliot M. Meyerowitz (California Institute of Technology):
How Plants Grow: Molecules, Cells and Computers
|Fri, 29/11/13||Seminar by Prof Charles Dorman (Department of Microbiology, TCD):
Regulon Evolution - The Latest Twist
|Fri, 22/11/13||Seminar by Dr. Brian Hendrich (Cambridge Stem Cell Institute, UK):
Transcriptional control of stem cell fate
|Fri, 15/11/13||Seminar by Dr. Andrea Manica (Dept of Zoology, University of Cambridge):
The long march of human genes: Reconstructing the out of Africa expansion of anatomically modern humans
|Fri, 01/11/13||Seminar by Diarmuid O'Maoileidigh from Frank Wellmer's lab and Conor Henry from Seamus Martin's lab.|
|Fri, 25/10/13||Seminar by Andrew Jackson:|
Evolution of Perception and Behaviour
Aoife McLysaght has invited Dr. Andrew Jackson from the School of Natural Sciences in Trinity College to give a seminar on Friday at 1:00 pm in the Smurfit Atrium.
The title of his seminar will be "Evolution of Perception and Behaviour".
Dr. Andrew Jackson is a behavioural ecologist and evolutionary biologist in the School of Natural Sciences in Trinity College Dublin. His work focuses on the evolution of social behaviour and includes elements of game theory, comparative approaches, social network analysis, artificial neural networks and genetic algorithms. He also collaborates on more general ecological and health related projects from a theoretical perspective. He graduated in zoology in Trinity College Dublin and did a PhD in theoretical ecology in University of Glasgow before returning to Trinity as a postdoc and then lecturer in 2007.
Healy, K., McNally, L., Ruxton, G.D., Cooper, N. & Jackson, A.L. 2013. Metabolic rate and body size linked with perception of temporal information. Animal Behaviour, 86(4), 685-696 [dx.doi.org].
Wakefield, E.D., Bodey, T.W., Bearhop, S., Blackburn, J., Colhoun, K., Davies, R., Dwyer, R.G., Green, J., Gr?millet, D.,Jackson, A.L., Jessopp, M.J., Kane, A., Langston, R.H.W., Lescro?l, A., Murray, S., Le Nuz, M., Patrick, S.C., P?ron, C., Soanes, L., Wanless, S., Votier, S.C., & Hamer, K.C. 2013. Space Partitioning Without Territoriality in Gannets. Science, 341(6141), 68-70. [dx.doi.org]
McNally, L., Jackson, A.L. 2013. Cooperation creates selection for tactical deception. Proceedings of the Royal Society of London B, 280(1762), [dx.doi.org]
McNally, L., Brown, S.P. & Jackson, A.L. 2012. Cooperation and the evolution of intelligence. Proceedings of the Royal Society of London B, 279, 3027-3034. [dx.doi.org]
|Fri, 18/10/13||Seminar by Anton Enright:|
Small RNAs and their Roles in Genomic Regulation
Karsten Hokamp has invited Dr. Anton Enright from the European Bioinformatics Institute, Cambridge, UK to give a seminar on Friday at 1:00 pm in the Smurfit Atrium.
The title of his seminar will be "Small RNAs and their Roles in Genomic Regulation".
Anton Enright is a graduate of the Trinity College Genetics department. He first developed his bioinformatics skills as an undergraduate workingwith Prof. Ken Wolfe before moving to the European Bioinformatics Institute in Cambridge for his Ph.D. studies on the computational prediction of protein-protein interactions. His Postdoctoral work was undertaken with Chris Sander at Memorial Sloan-Kettering Cancer Centre in New York. He started his first independent position at the Wellcome Trust Sanger Institute in Cambridge working on computational prediction of the functions of microRNAs. In 2008 he moved back to the European Bioinformatics Institute as a research group leader working on the computational genomics of small RNAs and their roles in various biological systems including early development and the mouse germ line. His talk will focus on the roles of piwiRNAs in regulating transposons in the mouse germ line and discuss other non-coding RNAs including microRNAs and long non-coding RNAs.
Selected Recent Publications:
Kraken: A set of tools for quality control and analysis of high-throughput sequence data.
Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis.
Large-scale analysis of microRNA evolution.
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
Detecting microRNA binding and siRNA off-target effects from expression data.
|Fri, 11/10/13||Seminar by Kevin Devine:|
Regulation of cell wall metabolism in Bacillus subtilis
This weeks seminar will be given by our own Prof. Kevin Devine on Friday at 1:00 pm in the Smurfit Atrium.
The title of his seminar will be "Regulation of cell wall metabolism in Bacillus subtilis".
Research in the Devine Lab:
The research focus of the Devine laboratory is the Regulation of Cell Wall Metabolism in Gram Positive bacteria using Bacillus subtilis as a model system.
The cell wall of Gram positive bacteria such as Bacillus subtilis is located exterior to the cytoplasmic membrane and is composed of peptidoglycan and an anionic polymer (often teichoic acid). Together these polymers form a multilayered mesh-type protective sacculus that imparts shape to the cell, resists turgor pressure and is the structure through which the bacterium interacts with its environment. Cell wall integrity is essential for cell viability - agents that disrupt cell wall synthesis or structure, such as eg. the penicillin or vancomycin antibiotics, leads to cell death. Nevertheless, up to 50% of the cell wall polymer is synthesized and turned over during each cell cycle. Thus the cell wall is a highly dynamic structure. Much current research in this area is focused on establishing how cell wall synthesis and turnover are regulated both spatially and temporally and on how this is achieved without compromising cell wall integrity and cell viability.
Their recent work has focused on the bi-location of cell wall metabolic activities - how the production of peptidoglycan and teichoic acid precursors in the cytoplasm is coordinated with cell wall synthesis and turnover within the exterior cell wall. Their work has revealed that the WalRK and PhoPR two-component signal transduction systems, together with a Sigma / anti-sigma factor system (SigI RsgI) play central roles in controlling cell wall metabolism during growth and under stress conditions. Their work is also focused on identifying the molecular signals identified by the WalK and PhoR sensor kinases.
These subjects will be the focus of the seminar.
Some recent papers:
1. Salzberg LI, Powell L, Hokamp K, Botela E, Noone D, Devine KM. (2013). The WalRK (YycFG) and ?(I) RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells.
2. Bisicchia P, Bui NK, Aldridge C, Vollmer W, Devine KM. (2011). Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology.
3. Bisicchia P, Lioliou E, Noone D, Salzberg LI, Botella E, H?bner S, Devine KM. (2010). Peptidoglycan metabolism is controlled by the WalRK (YycFG) and PhoPR two-component systems in phosphate-limited Bacillus subtilis cells.
|Fri, 04/10/13||Seminar by José Luis Riechmann (Center for Research in Agricultural Genomics, Barcelona):|
Genomic Analyses of Gene Regulatory Networks in Plants
Frank has invited Prof José Luis Riechmann from the Center for Research in Agricultural Genomics (CRAG) in Barcelona, to give a seminar this Friday at 1:00pm in the Smurfit Atrium.
The title of his seminar will be "Genomic Analyses of Gene Regulatory Networks in Plants".
José Luis Riechmann is the director of the Center for Research in Agricultural Genomics (CRAG) in Barcelona. He is one of the leading authorities on plant transcription factors and has worked for many years on the characterisation of gene regulatory mechanisms underlying diverse processes during plant development.
His recent papers include:
Huang, W., Pérez-García, P., Pokhilko, A., Millar, A.J., Antoshechkin, I., Riechmann, J.L., Mas, P. (2012) Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator. Science 336, 75-79.
Kaufmann, K., Wellmer, F., Muiño, J.M., Ferrier, T., Wuest, S.E., Kumar, V., Serrano-Mislata, A., Madueño, F., Krajewski, P., Meyerowitz, E.M., Angenent, G.C., and Riechmann, J.L. (2010) Orchestration of floral initiation by APETALA1. Science 328, 85-89.
|Fri, 27/09/13||Seminar by Scott Armstrong (Memorial Sloan-Kettering Cancer Center):|
Targeting Histone Methylation in Leukemia Stem Cells
Adrian has invited Prof Scott Armstrong, director of the Memorial Sloan-Kettering Leukemia Center, to give a seminar this Friday at 1:00pm in the Smurfit Atrium.
The title of his seminar will be "Targeting Histone Methylation in Leukemia Stem Cells"
Scott Armstrong's Research:
The goal of Scott Armstrong's research program is to define genetic and epigenetic programs that control the extensive self-renewal properties associated with leukemia and other cancers. This knowledge is then used to develop rational approaches for potential new therapies. Experiments incorporate the use of sophisticated mouse models of leukemia and the characterization of human leukemia cells.
Prof. Armstrong's lab recently identified leukemia stem cells in a model of human leukemia and demonstrated that acute myelogenous leukemia stem cells express a stem cell program in the context of a more differentiated cell type. This finding has important implications for therapeutic approaches that will target cancer stem cells.
His lab also defined changes in chromosome structure as a critical initial step in leukemia development. These findings have prompted a search for therapies that can reverse this process and eradicate leukemia stem cells. Prof. Armstrong's work is driven by questions that are of immediate clinical relevance and a number of clinical trials have been developed as a direct result of this work.
Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA , Armstrong SA. 2012. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell, (1934-5909), 2012 Sept 07; 11 (3)429.
Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis K, Lane SW, Armstrong SA. Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib Resistant Leukemia Stem Cells in CML. Cell Stem Cell, 2012 Apr 6;10(4)412-24.
Neff TA, Sinha AU, Kluk MJ, Zhu N, Khattab M, Stein L, Zie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc. Natl. Acad. Sci. 2012 Mar 27;109(13)5028-33.
Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Mancarci OB, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602.
Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA. MLL-rearranged Leukemia is Dependent on Aberrant H3K79 Methylation by DOT1L. Cancer Cell 2011, Jul 12;20(1)66-78.
Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, Johnson LD, Scott MP, Smith JJ, Xiao Y, Jin L, Kuntz KW, Chesworth R, Moyer MP, Bernt KM, Tsend JC, Kung AL, Armstrong SA, Copeland RA, Richon VM, Pollock RM. Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor. Cancer Cell 2011, Jul 12;20(1)53-65.
Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26;327(5973):1650-3.
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008 Nov 4; 15(5):355-68.
Wei G, Twomey D, Lamb J, Agarwal J, Stam R, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA. Gene expression-based chemical genomics identifies rapamycin as a modulator of glucocorticoid resistance. Cancer Cell. 2006: 10, 331-42.
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA. Transformation from committed progenitor to leukaemia stem cell initiated by MLL AF-9. Nature. 2006: 442, 818-22.
|Tue, 03/05/13||Seminar by Peter Kirwan (Gurdon Institute, University of Cambridge):|
Modelling human cortical networks from pluripotent stem cells in development and disease
SPECIAL SEMINAR, 1 pm, Genetics Atrium
Peter Kirwan is a graduate of the Trinity College Genetics department, currently completing his PhD with Rick Livesey at Cambridge, where they are pioneering the derivation of cortical neuronal cell-types from induced pluripotent stem cells from human patients to model cortical development and disease.
Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.
A human stem cell model of early Alzheimer's disease pathology in Down syndrome.
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
|Tue, 23/04/13||Seminar by Shane McCarthy (Cold Spring Harbor Laboratory):|
Harvesting Rare Variation in Schizophrenia
SPECIAL SEMINAR, 1 pm, Atrium
Shane McCarthy is a genomics researcher studying the genetics of psychiatric and neurodevelopmental disorders. He has helped pioneer the application of whole-genome array and sequencing approaches to identify rare mutations causing schizophrenia, autism and related conditions.
High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders.
Microduplications of 16p11.2 are associated with schizophrenia.
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
|Fri, 22/03/13||Seminar by Jose Luis Riechmann|
|Fri, 15/03/13||Seminar by Ludovic Orlando|
|Fri, 08/03/13||Seminar by Steven Spoel|
|Fri, 15/02/13||Seminar by Dr John Stingl (University of Cambridge):
Mammary stem and progenitor cells: Understanding the cellular context of breast cancer
Adrian has invited Dr John Stingl from the Department of Oncology, University of Cambridge to give a seminar this Friday at 1:00pm in the Smurfit Atrium.
The title of his seminar will be "Mammary stem and progenitor cells: Understanding the cellular context of breast cancer"
The research of Dr John Stingl focuses on identifying stem and progenitor cells in both the human and mouse mammary glands. He is interested in these cells because cancer theory suggests that it is these cells that are the initial targets for malignant transformation in breast cancer. He is also interested in understanding the influence of common breast cancer-associated mutations on normal breast stem and progenitor cell function and identifying the cell of origin of different types of breast tumours.
Enzymatic dissociation, flow cytometric analysis, and culture of normal mouse mammary tissue.
TGFbeta induces the formation of tumour-initiating cells in claudinlow breast cancer.
Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay.
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis.
Purification and unique properties of mammary epithelial stem cells.
|Fri, 08/02/13||Seminar by Dr Adrian Bracken (TCD):
Epigenetic 'reader' proteins in stem cells and cancer
|Fri, 01/02/13||Seminar by Prof Ken Wolfe (TCD):
Yeast genome evolution - Shuffling and shrinking
|Fri, 25/01/13||Seminar by Dagmar Kulms (University of Dresden):
Breaking TRAIL resistance of malignant melanoma