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Professor Joseph Keane
Professor of Medicine 1955, Clinical Medicine
Professor of Medicine 1955, School Office - Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Connor G, Krishnan N, Fagan-Murphy A, Cassidy J, O'Leary S, Robertson BD, Keane J, O'Sullivan MP, Cryan SA., Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection., European Journal of Pharmaceutics and Biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134, 2019, p153-165 Journal Article, 2019 DOI

Phelan JJ, Basdeo SA, Tazoll SC, McGivern S, Saborido JR and Keane J, Modulating Iron for Metabolic Support of TB Host Defense, Frontiers in Immunology, 2018 Journal Article, 2018 TARA - Full Text URL

Schwander, S. and Keane, J., Cause or effect? the elusive role of regulatory t cells in tuberculosis, American Journal of Respiratory and Critical Care Medicine, 198, (1), 2018, p11-12 Journal Article, 2018 DOI

Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156- Journal Article, 2018 URL

Roycroft E, O'Toole RF, Fitzgibbon MM, Montgomery L, O'Meara M, Downes P, Jackson S, O'Donnell J, Laurenson IF, McLaughlin AM, Keane J, Rogers TR., Molecular epidemiology of multi- and extensively-drug-resistant mycobacterium tuberculosis in ireland, 2001-2014., The Journal of infection, 76, (1), 2018, p55-67 Journal Article, 2018 DOI

Gleeson LE, O'Leary SM, Ryan D, McLaughlin AM, Sheedy FJ, Keane JM., Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection., American journal of respiratory cell and molecular biology, 2018 Journal Article, 2018 DOI

Coleman MM, Basdeo SA, Coleman AM, Cheallaigh CN, Peral de Castro C, McLaughlin AM, Dunne PJ, Harris J, Keane J., All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection., American journal of respiratory cell and molecular biology, 59, (5), 2018, p548-556 Journal Article, 2018 DOI

Cambier CJ, O'Leary SM, O'Sullivan MP, Keane J, Ramakrishnan L., Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages., Immunity, 47, (3), 2017, p552 - 565 Journal Article, 2017 DOI TARA - Full Text

Chong SG, McLaughlin AM, Keane J., Response: Disseminated tuberculosis., QJM : monthly journal of the Association of Physicians, 110, (5), 2017, p333 Journal Article, 2017 TARA - Full Text DOI

Chong Sy Giin, Herron Malcolm, Dorman Anthony, Little Mark, Donnelly Seamas C, Keane Joseph, McLaughlin Anne Marie, Renal amyloidosis complicating multidrug-resistant tuberculosis , The International Journal of Tuberculosis and Lung Disease , 21 , (4 ), 2017, p476 - 477 Journal Article, 2017

Branagan P, Moran B, Fitzgibbon M, Reid V, McMenamin M, Kane M, Kelly F, Barnes L, McLaughlin A, Keane J, Inoculation site leprosy in a tattoo as a paradoxical reaction following tuberculosis treatment., The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 20, (5), 2016, p706-8 Journal Article, 2016

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 TARA - Full Text URL

O'Connor G, Gleeson LE, Fagan-Murphy A, Cryan SA, O'Sullivan MP, Keane J, Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery., Advanced Drug Delivery Reviews, 102, 2016, p33 - 54 Journal Article, 2016 URL

Berg RD, Levitte S, O'Sullivan MP, O'Leary SM, Cambier CJ, Cameron J, Takaki KK, Moens CB, Tobin DM, Keane J, Ramakrishnan L, Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration., Cell, 165, (1), 2016, p139 - 152 Journal Article, 2016 URL

Buckley A, McDonnell C, Keane J, McLaughlin AM, First Case of Multidrug Resistant Spinal TB in Ireland. , Irish medical journal , 109 , (9 ), 2016, p473 - Journal Article, 2016

Lawlor C, O'Connor G, O'Leary S, Gallagher PJ, Cryan SA, Keane J, O'Sullivan MP, Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF"B and Autophagy Dependent Bacillary Killing., PloS one, 11, (2), 2016, pe0149167 Journal Article, 2016 DOI URL

Lewinsohn David M, Leonard Michael K, LoBue Philip A, Cohn David L, Daley Charles L, Desmond Ed, Keane Joseph, Lewinsohn Deborah A, Loeffler Ann M, Mazurek Gerald H, Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children , Clinical Infectious Diseases , 2016, pciw694 - Journal Article, 2016 DOI TARA - Full Text

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 Journal Article, 2016 TARA - Full Text DOI URL

Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885 Journal Article, 2016 DOI

Judge E., Ahmed M., Fitzgibbon M., McLaughlin A., Keane J., Mycobacterium avium complex pulmonary disease: Characteristics and treatment in an Irish patient cohort, Irish Medical Journal, 109, (4), 2016, p398 Journal Article, 2016

Chong SG, Herron M, Dolan L, McDonald C, O'Donnell R, Fahy RJ, Keane J, McLaughlin AM, TB osteomyelitis , QJM , 2016, phcw166 - Journal Article, 2016 DOI TARA - Full Text

O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J, Cigarette Smoking Impairs Human Pulmonary Immunity to Mycobacterium tuberculosis., American journal of respiratory and critical care medicine, 190, (12), 2015, p1430-1436 Journal Article, 2015 DOI

Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347 Miscellaneous, 2015 DOI

Gleeson, L.E., Varghese, C., Ryan, E., Kane, M., Mcdonald, C., Gleeson, N., McLaughlin, A.-M., Butler, K., Gavin, P., Keane, J., Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis, QJM, 108, (11), 2015, p899-901 Journal Article, 2015 DOI TARA - Full Text

Gleeson LE, Varghese C, Ryan E, Kane M, McDonald C, Gleeson N, McLaughlin AM, Butler K, Gavin P, Keane J, Untreated Chronic Tuberculous Salpingitis followed by successful IVF Conception and Congenital Tuberculosis., QJM : monthly journal of the Association of Physicians, 2015 Journal Article, 2015 DOI TARA - Full Text

Silvestri GA, Vachani A, Whitney D, Elashoff M, Porta Smith K, Ferguson JS, Parsons E, Mitra N, Brody J, Lenburg ME, Spira A, A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer., The New England journal of medicine, 373, (3), 2015, p243-51 Journal Article, 2015 DOI

Gleeson LE, Keane J, First Steps in Biomarker Assessment for Reactivation Risk in Latent Tuberculosis Infection., American journal of respiratory and critical care medicine, 192, (5), 2015, p534-5 Journal Article, 2015

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80 Journal Article, 2015 DOI TARA - Full Text

Lyons J, Vandenberghe E, Fahy R, McDonnell C, Keane J, McLaughlin AM, An unusual lung mass post stem cell transplantation., Transplant infectious disease : an official journal of the Transplantation Society, 16, (4), 2014, p672-675 Journal Article, 2014 DOI

Hoefsloot W, van Ingen J, Andrejak C, Angeby K, Bauriaud R, Bemer P, Beylis N, Boeree MJ, Cacho J, Chihota V, Chimara E, Churchyard G, Cias R, Dasa R, Daley CL, Dekhuijzen PN, Domingo D, Drobniewski F, Esteban J, Fauville-Dufaux M, Folkvardsen DB, Gibbons N, Gómez-Mampaso E, Gonzalez R, Hoffmann H, Hsueh PR, Indra A, Jagielski T, Jamieson F, Jankovic M, Jong E, Keane J, ... Winthrop K, Wagner D, The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: A NTM-NET collaborative study., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 42, (6), 2013, p1604-1613 Journal Article, 2013 TARA - Full Text DOI

Kane M, Korn B, Saukkonen J, McDonald C, Walsh C, Waters R, McLaughlin AM, Keane J, Barriers to accepting and completing latent tuberculosis infection treatment., Irish medical journal, 106, (7), 2013, p200-4 Journal Article, 2013

Doherty AM, Kelly J, McDonald C, O'Dywer AM, Keane J, Cooney J, A review of the interplay between tuberculosis and mental health., General hospital psychiatry, 35, (4), 2013, p398-406 Journal Article, 2013 DOI

Ní Cheallaigh C, Fitzgerald I, Grace J, Jagjit Singh G, El-Eraki N, Gibbons N, Keane J, Rogers TR, Clarke S, Bergin C, Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country., PloS one, 8, (1), 2013, pe53330 Journal Article, 2013 DOI TARA - Full Text

Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80 Journal Article, 2013 TARA - Full Text DOI

Lawlor C, O'Sullivan MP, Rice B, Dillon P, Gallagher PJ, O'Leary S, Shoyele S, Keane J, Cryan SA, Therapeutic aerosol bioengineering of targeted, inhalable microparticle formulations to treat Mycobacterium tuberculosis (MTb)., Journal of Materials Science. Materials in Medicine, 23, (1), 2012, p89 - 98 Journal Article, 2012 DOI

McLaughlin AM, Gibbons N, Fitzgibbon M, Power JT, Foley SC, Hayes JP, Rogers T, Keane J, Primary Isoniazid Resistance in Mycobacterium bovis Disease: A Prospect of Concern., American Journal of Respiratory and Critical Care Medicine, 186, (1), 2012, p110-1 Journal Article, 2012 URL DOI

Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H., The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis, FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413-424 Journal Article, 2012 TARA - Full Text DOI

Macdonald SH, Woodward E, Coleman MM, Dorris ER, Nadarajan P, Chew WM, McLaughlin AM, Keane J, Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis., PloS one, 7, (6), 2012, pe38488 Journal Article, 2012 TARA - Full Text DOI

Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424 Journal Article, 2012 DOI

Kiely B, McLaughlin AM, Lynch TH, Keane J., Intravesical bacille Calmette-Guérin-induced multiorgan failure after treatment for transitional cell carcinoma., Scand J Urol Nephrol, 45, (4), 2011, p278 - 280 Journal Article, 2011

Ní Cheallaigh C, Keane J, Lavelle EC, Hope JC, Harris J., Autophagy in the immune response to tuberculosis: clinical perspectives., Clinical and Experimental Immunology, 164, (3), 2011, p291 - 300 Journal Article, 2011 DOI

Hassan, T.M., Keane, J., McLaughlin, A.M., Paradoxical response involving tuberculous arthritis with soft tissue abscess in a female patient with disseminated tuberculosis, non-HIV infection, lymphopenia and vitamin D deficiency. Coincidence or immunological enigma? | Réaction paradoxale entraînant une arthrite tuberculeuse avec abcès des parties molles chez une patiente atteinte d'une tuberculose disséminée, non infectée par le VIH, lymphopénique et carencée en vitamine D. Coïncidence ou énigme immunologique?, Revue du Rhumatisme (Edition Francaise), 78, (2), 2011, p197-198 Journal Article, 2011

Hassan TM, Keane J, McLaughlin AM., Paradoxical reaction causing tuberculous arthritis and soft-tissue abscess in a non-HIV infected, lymphopenic, vitamin D deficient patient with disseminated tuberculosis. A coincidence or an immunological conundrum?, Joint Bone Spine, 78, (3), 2011, p322 - 323 Journal Article, 2011 DOI

Lawlor C, Kelly C, O'Leary S, O'Sullivan MP, Gallagher PJ, Keane J, Cryan SA., Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of MTb., Tuberculosis, 91, (1), 2011, p93 - 97 Journal Article, 2011

Lawlor C, Kelly C, O'Leary S, O'Sullivan M, Gallagher PJ, Keane J Cryan SA, Cellular targeting and trafficking of drug delivery systems for the prevention and treatment of tuberculosis, Tuberculosis, 91, (1), 2011, p93 - 97 Journal Article, 2011

Ryan RC, O'Sullivan MP, Keane J, Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells., BMC Microbiology, 11, 2011, p237- Journal Article, 2011 TARA - Full Text

Anandaiah, A., Dheda, K., Keane, J., Koziel, H., Moore, D.A.J., Patel, N.R., Novel developments in the epidemic of human immunodeficiency virus and tuberculosis coinfection, American Journal of Respiratory and Critical Care Medicine, 183, (8), 2011, p987-997 Journal Article, 2011

Cahill KC, Conroy FJ, Brown A, Dunlop RL, Eadie P, Keane J, Tuberculous dactylitis in the setting of low serum vitamin D - A case report., J Plast Reconstr Aesthet Surg, 64, (12), 2011, p321 - 324 Journal Article, 2011

Kennedy B, Connor B, Korn B, Gibbons N, O'Connor T, Keane J, Multi-drug resistant tuberculosis: experiences of two tertiary referral centres., Irish medical journal, 104, (6), 2011, p182-5 Journal Article, 2011

Lawlor, C., O'Sullivan, M.P., Sivadas, N., O'Leary, S., Gallagher, P.J., Keane, J., Cryan, S.-A., The application of high-content analysis in the study of targeted particulate delivery systems for intracellular drug delivery to alveolar macrophages, Molecular Pharmaceutics, 8, (4), 2011, p1100-1112 Journal Article, 2011

Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA., The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Mol Pharm, 8, (4), 2011, p1100 - 1112 Journal Article, 2011

Alexander W. Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich, Caroline Breysach, Dirk Raddatz, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Julia Kzhyshkowska, Alexei Gratchev, Stefan Schweyer, Bernadette Saunders, Johannes T. Wessels, Wiebke Möbius, Joseph Keane, Heinz Becker, Arnold Ganser, Michael Neumaier, Wolfgang E. Kaminski, A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis, PLoS Pathogens, 7, (11, e1002375), 2011 Journal Article, 2011 TARA - Full Text

T Hassan, AM McLaughlin, F O'Connell, N Gibbons, S Nicholson, J Keane, EBUS-TBNA performs well in the diagnosis of isolated thoracic tuberculous lymphadenopathy, American Journal of Respiratory and Critical Care Medicine , 183, (1), 2011, p136 - 137 Journal Article, 2011

S O'Leary, M O'Sullivan, J Keane, IL-10 blocks phagosome maturation in Mycobacterium tuberculosis-infected human macrophages, American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180 Journal Article, 2011

Anandaiah A, Dheda K, Keane J, Koziel H, Moore DA, Patel NR, Novel Developments in the Epidemic of HIV and TB Co-Infection., Am J Respir Crit Care Med, 183, (8), 2011, p987 - 997 Journal Article, 2011

Cryan, S.-A., Hibbitts, A., Yadav, A., Kelly, C., Jefferies, C., Greene, C., McElvaney, N.G., O'sullivan, M., Keane, J., Lawlor, C., Barlow, J., Therapeutic aerosol bioengineering for targeted delivery in the lungs, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011 Journal Article, 2011

Coleman, M.M., Keane, J., Mills, K.H.G., Editorial: Tregs and BCG - Dangerous liaisons in TB, Journal of Leukocyte Biology, 88, (6), 2010, p1067-1069 Journal Article, 2010 DOI TARA - Full Text

Martin J, Walsh C, Gibbs A, McDonnell T, Fearon U, Keane J, Codd MB, Dodd JD, Veale D, Fitzgerald O, Bresnihan B., Comparison of interferon-gamma-release assays and conventional screening tests before tumour necrosis factor-alfa blockade in patients with inflammatory arthritis, Annals of Rheumatological Diseases, 69, (1), 2010, p181 - 185 Journal Article, 2010 DOI

Chan, E.D. Keane, J., Iseman, M.D, Should cigarette smoke exposure be a criterion to treat latent tuberculous infection?, American Journal of Respiratory and Critical Care Medicine, 182, 2010, p990 - 992 Journal Article, 2010

James Harris, Joseph Keane, How tumour necrosis factor blockers interfere with tuberculosis immunity., Clinical and Experimental Immunology, 161, (1), 2010, p1 - 9 Journal Article, 2010 TARA - Full Text

Harris J, Keane J, How TNF Blockers Interfere with TB Immunity, Clinical and Experimental Immunology , 161, (1), 2010, p1 - 9 Journal Article, 2010

Coleman MM, Keane J, Mills KH., Tregs and BCG--dangerous liaisons in TB., Journal of Leukocyte Biology, 88, (6), 2010, p1067 - 1069 Journal Article, 2010 DOI

Siddiqui UA, O'Toole M, Kabir Z, Qureshi S, Gibbons N, Kane M, Keane J, Smoking prolongs the infectivity of patients with tuberculosis., Irish medical journal, 103, (9), 2010, p278-80 Journal Article, 2010

Lee C.L., Doran, M, Keane J., Tuberculosis associated with tumor necrosis factor blocker therapy despite following guidelines, 2009 Journal Article, 2009

Keane, Joseph, Regulatory Role of CD4+, 2009, - Miscellaneous, 2009

Harris, J., Master, S.S., De Haro, S.A., Delgado, M., Roberts, E.A., Hope, J.C., Keane, J., Deretic, V. , Th1-Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages, Veterinary Immunology and Immunopathology , 128, (1-3), 2009, p37-43 Journal Article, 2009 DOI

Harris, J., Hope, J. C., Keane, J., Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis, Journal of Infectious Diseases, 198, (12), 2008, p1842 - 1850 Journal Article, 2008 DOI TARA - Full Text

McLaughlin AM, Donnell RA, Nicolson S, Keane J, Young VK, A pulmonary mass with invasion into the heart., International Seminars in Surgical Oncology, 5, (1), 2008, particle no 24 Journal Article, 2008 TARA - Full Text DOI

Keane, J and Bresnihan, B, Tuberculosis reactivation during immunosuppressive therapy in rheumatic diseases: Diagnostic and therapeutic strategies, Current Opinions in Rheumatology , 20, (4), 2008, p443 - 449 Journal Article, 2008 DOI

Kelly, D. ten Bokum, AM.C., O'Leary, S., O'Sullivan, M., Keane, J., Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection, Infection and Immunity , Jan;76, (1), 2008, p351 - 360 Journal Article, 2008 DOI URL

Meade KG, Gormley E, O'Farrelly C, Park SD, Costello E, Keane J, Zhao Y, Machugh DE., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC Genomics, 29, (9), 2008, p447- Journal Article, 2008 TARA - Full Text DOI

Kelly, DM, ten Bokum, AM, O'Leary, SM, O'Sullivan, MP, Keane, J, Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection., Infection and Immunity, 76, (1), 2008, p351 - 360 Journal Article, 2008 TARA - Full Text DOI

Molloy D, Sayana MK, Keane J, Mehigan B., Anal fistula: an unusual presentation of tuberculosis in a migrant health care professional., Irish Journal of Medical Science, 2008, p1-3 Journal Article, 2008 DOI

Bothamley GH, Ditiu L, Migliori GB, Lange C; TBNET contributors., Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey., European Respiratory Journal, 32, (4), 2008, p1023-1030 Journal Article, 2008 DOI TARA - Full Text

Sopp P, Coad M, Hewinson G, Howard CJ, Cheallaigh CN, Keane J, Harris J, Hope JC., Development of a simple, sensitive, rapid test which discriminates BCG vaccinated from Mycobacterium bovis-infected cattle, Vaccine, 26, (43), 2008, p5470-5476 Journal Article, 2008 DOI

Harris, J., Hope, JC. and Keane, J., Tumor-necrosis factor blockers influence macrophage responses to M. tuberculosis, The Journal of Infectious Diseases , 198, (12), 2008, p1842-1850 Journal Article, 2008 DOI

Keane J, Ní Cheallaigh C., Making tumor necrosis factor blockers safer: a prescriber's consumptive challenge, Journal of Rheumatology, 35, (7), 2008, p1238 - 1239 Journal Article, 2008 URL

Kennedy B, Lyons O, McLoughlin AM, Gibbons N, O'Flanagan D, Keane J., Extensively drug-resistant tuberculosis: first report of a case in Ireland., EUROSURVEILLANCE, 13, (30), 2008, ppii=18935 Journal Article, 2008 URL TARA - Full Text

McLaughlin A, Keane J, Donnell RA, Dysphagia caused by lymphadenopathy - what is the differential diagnosis?, The Clinical Respiratory Journal , Dec; 1, (2), 2007, p122 - 124 Journal Article, 2007 URL DOI

Harris, J., De Haro, SA., Master,SS., Keane J, Roberts EA, Delgado, M and Deretic V, T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis, Immunity , Sep;27, (3), 2007, p505 - 517 Journal Article, 2007 DOI TARA - Full Text URL

McLaughlin, A.M., McMahon, C.J., Fitzpatrick, A., Keane, J., O'Donnell, R.A., Educational case: dysphagia caused by lymphadenopathy--what is the differential diagnosis?, The clinical respiratory journal, 1, (2), 2007, p122-124 Journal Article, 2007

McLaughlin A, Meaney JF, Keane J, Donnell RA, Left atrial invasion by pulmonary adenocarcinoma, Eur J Cardiothorac Surg., Mar 9, 2007, p936 Journal Article, 2007 DOI TARA - Full Text

Meade KG, Gormley E, Doyle MB, Fitzsimons T, O' Farrelly C, Costello E, Keane J, Zhao Y, MacHugh DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease, BMC Genomics, Oct 31; 8, (1: 400), 2007 Journal Article, 2007 URL TARA - Full Text DOI

A. Spira, J. Beane V. Shah G. Liu, K Steiling, F Schembri S Gilman, M Dumas, P Sebastiani Sriram Sridhar, X Yang, P Calner, J Beamis, J Keane, M Lenburg, JS Brody, Airway Epithelial Gene Expression in the Diagnostic Evaluation of Smokers with Suspect Lung Cancer, Nature Medicine, Mar; 13, (3), 2007, p361 - 366 Journal Article, 2007 DOI URL

O'Sullivan, M., Kelly, D., O'Leary, S., Keane, J., Macrophage cell death in response to M.tuberculosis infection is mediated by a caspase-independent pathway, Infection and Immunity, 75, (4), 2007, p1984 - 1993 Journal Article, 2007 DOI URL

O'Sullivan, MP, O'Leary, S, Kelly, DM, Keane, J, A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection., Infection and Immunity, 75, (4), 2007, p1984 - 1993 Journal Article, 2007 TARA - Full Text DOI

Harris, J., De Haro, S.A., Master, S.S., Keane, J., Roberts, E.A., Delgado, M., Deretic, V., T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis (DOI:10.1016/j.immuni.2007.07.022), Immunity, 27, (4), 2007 Journal Article, 2007

Meade KG, Gormley E, Park SD, Fitzsimons T, Rosa GJ, Costello E, Keane J, Coussens PM, Machugh DE., Gene expression profiling of peripheral blood mononuclear cells (PBMC) from Mycobacterium bovis infected cattle after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD)., Veterinary Immunology and Immunopathology , 113, (1-2), 2006, p73-89 Journal Article, 2006 URL DOI

Keane, J., TNF blocking agents and tuberculosis: new drugs illuminate an old topic, Rheumatology, Jun; 44, (6), 2005, p714 - 720 Journal Article, 2005 URL DOI

Ali S, Chew N, Manning P, Noonan N, Keane J and Bergin C. , The prevalence of Latent Pulmonary Tuberculosis (LTBI) in a Normal and High Risk Population Group. , 2005, - 397S-a Miscellaneous, 2005

Tuberculosis and apoptosis in, editor(s)William N. Rom and Stuart M.Garay , Tuberculosis, Philadelphia , Lippincott Williams & Wilkins, 2004, [J Keane] Book Chapter, 2004

Keane, J., Tumor Necrosis Factor Blockers and Reactivation of Latent Tuberculosis, Clinical Infectious Disease, 39, (3), 2004, p300 - 302 Journal Article, 2004 URL DOI

A. Bella, A.M.C. ten Bokum, N. Noonan, J. Rothel, P Kelly ,J. Keane , The Evaluation of the QuantiFERON TB test for the Diagnosis of Tuberculosis Disease and Latent Tuberculosis Infection (LTBI) in the Irish Population: Preliminary Results, Irish Journal of Medical Science , 173, (1), 2004, p33- Journal Article, 2004 URL

A.M.C. ten Bokum, M. O'Sullivan, J. Keane, Apoptosis of uninfected "bystander" macrophages in the presence of macrophages infected with Mycobacterium tuberculosis, Irish Journal of Medical Science , 173, (1), 2004, p56- Journal Article, 2004

Programmed cell death in tuberculosis in, editor(s)William N. Rom and Stuart M.Garay, with foreword by Barry R. Bloom. , Tuberculosis , Philadelphia , Lippincott Williams & Wilkins, 2004, [Joseph Keane and Hardy Kornfeld ] Book Chapter, 2004

A. Bella, A.M.C. ten Bokum, N. Noonan, J. Rothel, P Kelly ,J. Keane , The Evaluation of the QuantiFERON TB test for the Diagnosis of Tuberculosis Disease and Latent Tuberculosis Infection (LTBI) in the Irish Population: Preliminary Results, 2004, - 33 Miscellaneous, 2004

Berk J, Keane J, Seldin DC, Sanchorawala V, Koyama J, Dember L, Falk R, Persistent pleural effusions in primary systemic amyloidosis: etiology and prognosis, Chest, 124, (3), 2003, p969 - 977 Journal Article, 2003 URL DOI

Spira, A., Carroll, J.D., Liu, G., Aziz, Z., Shah, V., Kornfeld, H., Keane, J., Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated Mycobacterium tuberculosis: A Pivotal Role for Tumor Necrosis Factor, American Journal of Respiratory Cell and Molecular Biology, 29, (5), 2003, p545-551 Journal Article, 2003

Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld K, Keane J, Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated M. tuberculosis; A pivotal role for TNF, American Journal of Respiratory Cell and Molecular Biology, November; 29, (5), 2003, p545 - 551 Journal Article, 2003 URL DOI

Lim, W.S., Powell, R.J., Johnston, I.D., Zhang, Z., Correa, H., Bégué, R.E., De Rosa, F.G., Bonora, S., Di Perri, G., Myers, A., Clark, J., Foster, H., Riminton, S., Pearce, N., Basten, A., Keane, J., Gershon, S.K., Braun, M.M., Tuberculosis and treatment with infliximab [2] (multiple letters), New England Journal of Medicine, 346, (8), 2002, p623-626 Journal Article, 2002

Lucey EC, Keane J, Kuang PP, Snider GL, Goldstein RH, Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1ß receptor-deficient mice, Laboratory Investigation, Jan; 82, (1), 2002, p79 - 85 Journal Article, 2002 DOI TARA - Full Text

Keane J, Shurtleff B, Kornfeld H, TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-g independent manner, Tuberculosis, 82, (2-3), 2002, p55-61 Journal Article, 2002

Keane J., Gershon S.K., Braun M.M., Tuberculosis and Treatment with Infliximab, New England Journal of Medicine, 346, (8), 2002, p623 - 626 Journal Article, 2002 URL

Reid V and Keane J, Tuberculosis Mastoiditis and Cerebral Tuberculoma, New England Journal of Medicine, 347, (e6), 2002 Journal Article, 2002 URL URL

J J Saukkonen, B Bazydlo, M Thomas, RM. Strieter, J Keane, H Kornfeld, ß-Chemokines Are Induced by Mycobacterium tuberculosis and Inhibit Its Growth, Infection and Immunity, Apr; 70, (4), 2002, p1684 - 1693 Journal Article, 2002 DOI URL

Reid, V.A., Keane, J. , Images in clinical medicine. Tuberculous mastoiditis and cerebral tuberculoma. , The New England Journal of Medicine, 347, (23-24), 2002, pe6 Journal Article, 2002

Keane, J., Gershon, S., Wise, R.P., Mirabile-Levens, E., Kasznica, J., Schwieterman, W.D., Siegel, J.N., Braun, M.M., Tuberculosis associated with infliximab, a tumor necrosis factor "-neutralizing agent, New England Journal of Medicine, 345, (15), 2001, p1098-1104 Journal Article, 2001

Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel, JN, Braun MM , Tuberculosis Associated With Infliximab, a TNF a-Neutralizing Agent, New England Journal of Medicine , 345, (15), 2001, p1098 - 1104 Journal Article, 2001 URL URL

Akalin E, Chandrakantan A, Keane J, Hamburger RJ, Normouricemia in the Syndrome of Inappropriate Antidiuretic Hormone Secretion., American Journal of Kidney Diseases, 37, (1), 2001, pE8 Journal Article, 2001 DOI

Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, Golenbock DT, Vogel SN, Fenton MJ, Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses , Journal of Immunology, 166, (6), 2001, p4074-4082 Journal Article, 2001 URL

Carroll JD, Wallace RC, Keane J, Remold HG, Arbeit RD , Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusions. , Tubercle and Lung Disease, 80, (3), 2000, p117-130 Journal Article, 2000 DOI

Keane J, Remold H, Kornfeld H, Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages, Journal of Immunology, 164, (4), 2000, p2016-2020 Journal Article, 2000 URL TARA - Full Text

Fratazzi C, Arbeit RD, Carini C, B-Sablinska MK, Keane J, et al., Macrophage apoptosis in mycobacterial infections, Journal of Leukocyte Biology, 66, (5), 1999, p763-764 Journal Article, 1999 URL

Sablinska M, Keane J, Remold HG, & Kornfeld H , Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha., Journal of Immunology, 161, (5), 1998, p2636-2641 Journal Article, 1998 URL

Keane J, Gochuico B, Kasnica JM & Kornfeld H., (Cryptogenic fibrosing alveolitis) Usual Interstitial Pneumonitis Responsive to Corticosteroids following Varicella pneumonia , Chest, 113, (1), 1998, p249-251 Journal Article, 1998 DOI

Keane J, Cruikshank WW Center D & Kornfeld H et al., Conservation of Structure and Function between Human and Murine Interleukin-16, Journal of Immunology, 160, (12), 1998, p5945-5954 Journal Article, 1998 URL

Keane, J., Gochuico, B., Kasznica, J.M., Kornfeld, H., Usual interstitial pneumonitis responsive to corticosteroids following varicella pneumonia, Chest, 113, (1), 1998, p249-251 Journal Article, 1998

Keane J, Sablinska M, Remold HG, & Kornfeld H et al., Infection by Mycobacterium tuberculosis Promotes Human Alveolar Macrophage Apoptosis., Infection & Immunity, 65, (1), 1997, p298-304 Journal Article, 1997 URL

Cruikshank WW, Kornfeld H, Berman J, Keane J, Center D., Biological activity of Interleukin-16, Nature, 381, (6589), 1996, p29-30 Journal Article, 1996

O'Conner C, Gaffney K Keane J, & FitzGerald MX et al., alpha1-Proteinase Inhibitor, Elastase activity, and Lung Disease Severity in Cystic Fibrosis, American Review of Respiratory Diseases, 148, 1993, p1665-1670 Journal Article, 1993

Keane J, Chan F, Over J & Finucane P., Respiratory Failure in the Elderly Hospitalized Patient , Journal of the Hong Kong Geriatric Society , 3, (1), 1992, p32-34 Journal Article, 1992

Keane J & Finucane P., "Whose bed is it anyway?" , Care of the Elderly, 1992, p158 Journal Article, 1992

Donal Cox and Joseph Keane, Platelets and Tuberculosis: Small Cells, Not So Innocent Bystanders, American Journal of Respiratory and Critical Care Medicine, 0, (ja), 0, pnull Journal Article, 0 DOI

Non-Peer-Reviewed Publications

Keane, Joseph, Tuberculosis Guidelines: National TB Advisory Committee, 2008 Working Paper, 2008

Keane, Joseph, American Thoracic Society - Programme committee, In:American Thoracic Society Conference, 2005 Meetings /Conferences Organised, 2005

Keane, Joseph, Institute of Molecular Medicine: Programme committee , 2004 - present, 2004 Meetings /Conferences Organised, 2004

Keane, Joseph, International Conference on Cytokine Medicine , 2004 - present, 2004 Meetings /Conferences Organised, 2004

Keane, Joseph, Diagnostic Standards & Classification of Tuberculosis in Adults and Children Working Paper,

Keane, Joseph, TNF blockade and opportunistic infection -A position paper Working Paper,

Research Expertise

Description

THE HOST RESPONSE TO TUBERCULOSIS
  • Macrophage Responses We asses the macrophage response to infection using in vitro and ex vivo models of human alveolar macrophages infected with Mycobacterium tuberculosis. We have used these experiments to define the role of macrophage cytokine production, bacterial killing, phagolysosome maturation, and cell death in the immune response to tuberculosis. By using human alveolar macrophages from subjects undergoing bronchoscopy we have been able to define clinically relevant innate immune responses to this important organism.
  • Cell Mediated Immunity Using human and murine models of disease we have been able to characterise both the pro and anti inflammatory immune response to Mycobacterium tuberculosis. Specifically we have demonstrated new mechanism whereby human alveolar macrophages generate a tolerogenic response to Mtb infection; which is reflected in T-cell changes that can potentially accommodate the invading pathogen.
  • The study of tuberculosis susceptible human hosts In our translational work; we have characterised the immune response of patients taking TNF-Blockers, cigarette smokers, and patient deficient in vitamin D. In this regard we have helped define their unique host susceptibility to disease with Mycobacterium tuberculosis.
  • Dublin TB group Our lab is an integral part of the Trinity College Immunology Research centre, including investigators who do TB research such as L O'Neill, K. Mills, P. Fallon, E. Lavelle and C. O'Farrelly. We co-supervise work on new inhalable TB therapies for TB with Dr. Sally Ann Cryan (RCSI). These PI's and a critical mass of TB investigators across Dublin are available to collaborate on future grant calls, and include Prof. Stephen Gordon, mycobateriologist, UCD.
  • Clinical Tuberculosis Research With on-site access to the largest TB cohort in Ireland, we have been in a position to define the role of new diagnostic and therapeutic options for TB. We have reported on the use of EBUS-TBNA in the diagnosis of isolated mediastinal tuberculous lymphadenopathy. We have also defined the public health hazard of prolonged infectiousness seen in our patients who smoke cigarettes after commencement of anti-TB treatment.
  • New TB Diagnostics The role of IGRA in the diagnosis of Latent TB infection: We are undertaking bench experiments to improve the signal to noise ratio and potentially shorten the blood incubation period in IGRA tests. In our clinics, we are testing IGRA performance in selected populations that are uniquely susceptible to progression from LTBI to tuberculosis disease.
  • TB research is funded by SFI, HRB and the RCDH Trust
  • Lung Cancer
    • The genetic basis of lung cancer: At St. James's we see 25% of the Irish lung cancer patients. My lab is collaborating with Boston University who are looking at the genetic profile of cells from these patients to address the questions 'Why do some smoker get lung cancer, and some smokers do not'. It is hope that this transcriptomics approach will allow for early detection for this disease that is almost always lethal because it presents late.
    • The accurate staging of lung cancer using whole body MRI or PET
  • Keywords

    Apoptosis; Host, Pathogen interactions; Infectious diseases; Innate immunology; Lung Cancer; Medicine; Respiratory System

    Recognition

    Representations

    Director: TB Immunology Lab, School of Medicine

    Director: Clinical TB services, St. James's Supraregional Centre

    Program Chair: American Thoracic Society, MTPI Assembly 2012

    Awards and Honours

    Health Research Board: Clinical Scientist Award 2012

    Memberships

    TBNET, STOP TB Partnership, International Union Against Tuberculosis and Lung Disease

    Royal College of Physicians

    American Thoracic Society

    Irish Thoracic Society