Dr. Karsten Hokamp
Senior Experimental Officer - Bioinforma, Genetics
Publications and Further Research Outputs
Peer-Reviewed Publications
Canals R, Hammarlöf DL, Kröger C, Owen SV, Fong WY, Lacharme-Lora L, Zhu X, Wenner N, Carden SE, Honeycutt J, Monack DM, Kingsley RA, Brownridge P, Chaudhuri RR, Rowe WPM, Predeus AV, Hokamp K, Gordon MA, Hinton JCD., Adding function to the genome of African Salmonella Typhimurium ST313 strain D23580., PLoS biology, 17, (1), 2019, pe3000059
O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM., The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites., Molecular genetics and metabolism reports, 16, 2018, p20-22
Hammarlöf DL, Kröger C, Owen SV, Canals R, Lacharme-Lora L, Wenner N, Schager AE, Wells TJ, Henderson IR, Wigley P, Hokamp K, Feasey NA, Gordon MA, Hinton JCD., Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella., Proceedings of the National Academy of Sciences of the United States of America, 2018
Kröger C, MacKenzie KD, Alshabib EY, Kirzinger MWB, Suchan DM, Chao TC, Akulova V, Miranda-CasoLuengo AA, Monzon VA, Conway T, Sivasankaran SK, Hinton JCD, Hokamp K, Cameron ADS., The primary transcriptome, small RNAs and regulation of antimicrobial resistance in Acinetobacter baumannii ATCC 17978., Nucleic Acids Research, 2018
Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM., Circadian clock protein BMAL1 regulates IL-1ß in macrophages via NRF2., Proceedings of the National Academy of Sciences of the United States of America, 115, (36), 2018, pE8460-E8468
Kenny, Colin and McDonagh, Naomi and Lazaro, Antonio and O'Meara, Elaine and Klinger, Rut and O'Connor, Darran and Roche, Fiona and Hokamp, Karsten and O'Sullivan, Maureen J, Dysregulated mitogen-activated protein kinase signalling as an oncogenic basis for clear cell sarcoma of the kidney, The Journal of pathology, 244, (3), 2018, p334 - 345
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Bracken AP., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., Molecular Cell, 70, (3), 2018, p408-421
Ffrench B, Gasch C, Hokamp K, Spillane C, Blackshields G, Mahgoub TM, Bates M, Kehoe L, Mooney A, Doyle R, Doyle B, O'Donnell D, Gleeson N, Hennessy BT, Stordal B, O'Riain C, Lambkin H, O'Toole S, O'Leary JJ, Gallagher MF., CD10(-)/ALDH(-) cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy., Cell Death Disease, 19, (8), 2017, pe3128-
Bibollet-Bahena, Olivia and Okafuji, Tatsuya and Hokamp, Karsten and Tear, Guy and Mitchell, Kevin J, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus, PloS one, 12, (5), 2017, pe0177977
Streubel, G., Fitzpatrick, Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal, EMBO Journal, 36, 2017, p2216 - 2232
Flanagan PR, Liu NN, Fitzpatrick DJ, Hokamp K, Köhler JR, Moran GP., The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation., mSphere, 2, (6), 2017
Young, Conor P and Hillyer, Cory and Hokamp, Karsten and Fitzpatrick, Darren J and Konstantinov, Nikifor K and Welty, Jacqueline S and Ness, Scott A and Werner-Washburne, Margaret and Fleming, Alastair B and Osley, Mary Ann, Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast, BMC genomics, 18, (1), 2017, p107
Palfi A, Hokamp K, Hauck SM, Vencken S, Millington-Ward S, Chadderton N, Carrigan M, Kortvely E, Greene CM, Kenna PF, Farrar GJ, microRNA regulatory circuits in a mouse model of inherited retinal degeneration., Scientific reports, 6, 2016, p31431
Colgan AM, Kröger C, Diard M, Hardt WD, Puente JL, Sivasankaran SK, Hokamp K, Hinton JC, The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium., PLoS Genetics, 12, (8), 2016, pe1006258
Harris NL, Cock PJ, Lapp H, Chapman B, Davey R, Fields C, Hokamp K, Munoz-Torres M, The 2015 Bioinformatics Open Source Conference (BOSC 2015)., PLoS computational biology, 12, (2), 2016, pe1004691
Casey, Maura E and Meade, Kieran G and Nalpas, Nicolas C and Taraktsoglou, Maria and Browne, John A and Killick, Kate E and Park, Stephen D E and Gormley, Eamonn and Hokamp, Karsten and Magee, David A and MacHugh, David E, Analysis of the Bovine Monocyte-Derived Macrophage Response to Mycobacterium avium Subspecies Paratuberculosis Infection Using RNA-seq, Frontiers in immunology, 6, 2015, p23
Fitzgerald S, Dillon SC, Chao TC, Wiencko HL, Hokamp K, Cameron AD, Dorman CJ, Re-engineering cellular physiology by rewiring high-level global regulatory genes., Scientific reports, 5, 2015, p17653
Mansergh FC, Carrigan M, Hokamp K, Farrar GJ, Gene expression changes during retinal development and rod specification, Molecular Vision, 21, 2015, p61 - 87
Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA, Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1., Proceedings of the National Academy of Sciences of the United States of America, 112, (23), 2015, p7231-6
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP., Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients., FEBS J, 282, (18), 2015, p3455 - 3473
Srikumar S, Kröger C, Hébrard M, Colgan A, Owen SV, Sivasankaran SK, Cameron AD, Hokamp K, Hinton JC, RNA-seq Brings New Insights to the Intra-Macrophage Transcriptome of Salmonella Typhimurium., PLoS pathogens, 11, (11), 2015, pe1005262
Salzberg L.I, Botella E, Hokamp K, Antelmann H, Maaà S, Becher D, Noone D, Devine K.M, Genome-wide analysis of phosphorylated PhoP binding to chromosomal DNA reveals several novel features of the PhoPR-mediated phosphate limitation response in Bacillus subtilis, Journal of Bacteriology, 197, (8), 2015, p1492 - 1506
Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB, Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP, Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits., PLoS genetics, 10, (10), 2014, pe1004658
McLoughlin KE, Nalpas NC, Rue-Albrecht K, Browne JA, Magee DA, Killick KE, Park SD, Hokamp K, Meade KG, O'Farrelly C, Gormley E, Gordon SV, MacHugh DE, RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis., Frontiers in immunology, 5, 2014, p396
Caimano MJ, Sivasankaran SK, Allard A, Hurley D, Hokamp K, Grassmann AA, Hinton JC, Nally JE, A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni., PLoS pathogens, 10, (3), 2014, pe1004004
Killick KE, Magee DA, Park SD, Taraktsoglou M, Browne JA, Conlon KM, Nalpas NC, Gormley E, Gordon SV, MacHugh DE, Hokamp K, Key Hub and Bottleneck Genes Differentiate the Macrophage Response to Virulent and Attenuated Mycobacterium bovis., Frontiers in immunology, 5, 2014, p422
McCusker MP, Hokamp K, Buckley JF, Wall PG, Martins M, Fanning S, Complete Genome Sequence of Salmonella enterica Serovar Agona Pulsed-Field Type SAGOXB.0066, Cause of a 2008 Pan-European Outbreak., Genome announcements, 2, (1), 2014
Zarin AA, Asadzadeh J, Hokamp K, McCartney D, Yang L, Bashaw GJ, Labrador JP, A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection., Neuron, 81, (6), 2014, p1297-311
Salzberg, L.I., Powell, L., Hokamp, K., Botella, E., Noone, D., Devine, K.M. 2013, The WalRK (YycFG) and σI RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells, Molecular Microbiology, 87, (1), 2013, p180-195
Nalpas, Nicolas C Park, Stephen DE Magee, David A Taraktsoglou, Maria Browne, John A Conlon, Kevin M Rue-Albrecht, Kévin Killick, Kate E Hokamp, Karsten Lohan, Amanda J , Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro , BMC genomics , 14 , (1 ), 2013, p230 -
Kröger C, Colgan A, Srikumar S, Händler K, Sivasankaran SK, Hammarlöf DL, Canals R, Grissom JE, Conway T, Hokamp K, Hinton JC, An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium., Cell host & microbe, 14, (6), 2013, p683-95
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP., CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression, Developmental Cell, 26, (3), 2013, p223-236
David A. Magee, Maria Taraktsoglou, Kate E. Killick, Nicolas C. Nalpas, John A. Browne, Stephen D. E. Park, Kevin M. Conlon, David J. Lynn, Karsten Hokamp, Stephen V. Gordon, Eamonn Gormley, David E. MacHugh, Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis, PLoS ONE, 7, (2, e32034), 2012
Botella, E., Noone, D., Salzberg, L.I., Hokamp, K., Devine, S.K., Fogg, M., Wilkinson, A.J., Devine, K.M., High-resolution temporal analysis of global promoter activity in Bacillus subtilis, Methods in Microbiology, 39, 2012, p1-26
Kate E Killick, John A Browne, Stephen DE Park, David A Magee, Irene Martin, Kieran G Meade, Stephen V Gordon, Eamonn Gormley, Cliona O'Farrelly, Karsten Hokamp and David E MacHugh, Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes, BMC Genomics , 12, (611), 2011
Botella E, Hübner S, Hokamp K, Hansen A, Bisicchia P, Noone D, Powell L, Salzberg LI, Devine KM, Cell envelope gene expression in phosphate-limited Bacillus subtilis cells., Microbiology (Reading, England), 157, (Pt 9), 2011, p2470-2484
Song, XM, Connor, W, Hokamp, K, Babiuk, LA, Potter, AA, The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae., Microbial pathogenesis, 46, (1), 2009, p28 - 35
Makino, T, Hokamp, K, McLysaght, A, The complex relationship of gene duplication and essentiality., Trends in genetics, 25, (4), 2009, p152 - 155
Song, XM, Connor, W, Hokamp, K, Babiuk, LA, Potter, AA, Transcriptome studies on Streptococcus pneumoniae, illustration of early response genes to THP-1 human macrophages., Genomics, 93, (1), 2009, p72 - 82
Stoebel DM, Hokamp K, Last MS, Dorman CJ, Compensatory evolution of gene regulation in response to stress by Escherichia coli lacking RpoS., PLoS Genetics, 5, (10), 2009, pe1000671
Loscher, CJ, Hokamp, K, Wilson, JH, Li, T, Humphries, P, Farrar, GJ, Palfi, A, A common microRNA signature in mouse models of retinal degeneration., Experimental eye research, 87, (6), 2008, p529 - 534
Lynn, DJ, Winsor, GL, Chan, C, Richard, N, Laird, MR, Barsky, A, Gardy, JL, Roche, FM, Chan, TH, Shah, N, Lo, R, Naseer, M, Que, J, Yau, M, Acab, M, Tulpan, D, Whiteside, MD, Chikatamarla, A, Mah, B, Munzner, T, Hokamp, K, Hancock, RE, Brinkman, FS, InnateDB: facilitating systems-level analyses of the mammalian innate immune response., Molecular systems biology, 4, 2008
Song, XM, Connor, W, Hokamp, K, Babiuk, LA, Potter, AA, Streptococcus pneumoniae early response genes to human lung epithelial cells., BMC research notes, 1, 2008
Song, XM, Connor, W, Jalal, S, Hokamp, K, Potter, AA, Microarray analysis of Streptococcus pneumoniae gene expression changes to human lung epithelial cells., Canadian journal of microbiology, 54, (3), 2008, p189 - 200
Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ., The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns., BMC Genomics, 14, (8), 2007, p320-
Loscher CJ, Hokamp K, Kenna PF, Ivens AC, Humphries P, Palfi A, Farrar GJ., Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa., Genome Biology, 8, (11), 2007, pR248-
Dolan, J, Walshe, K, Alsbury, S, Hokamp, K, O'Keeffe, S, Okafuji, T, Miller, SF, Tear, G, Mitchell, KJ, The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns., BMC Genomics, 8, (320), 2007
Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu JJ, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FS, Hokamp K, Potter A, Babiuk LA, Griebel PJ, Hancock RE., Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide., Journal of Leukocyte Biology, 80, (6), 2006, p1563 - 1574
Mookherjee N, Brown KL, Bowdish DM, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers JP, Bryan J, Brinkman FS, Hancock RE, Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37, Journal of Immunology, 176, (4), 2006, p2455 - 2464
Hodgson PD, Aich P, Manuja A, Hokamp K, Roche FM, Brinkman FSL, Potter A, Babiuk LA, Griebel PJ, Effect of stress on viral-bacterial synergy in bovine respiratory disease: novel mechanisms to regulate inflammation, Comparative and Functional Genomics, 6, (4), 2005, p244 - 250
Hokamp, K., Wolfe, K.H., PubCrawler: keeping up comfortably with PubMed and GenBank, Nucleic Acids Res, 32, 2004, pW16-W19
Roche FM, Hokamp K, Acab M, Babiuk LA, Hancock RE, Brinkman FS, ProbeLynx: a tool for updating the association of microarray probes to genes., Nucleic Acids Research, 32, (Web Server Issue), 2004, pW471 - W474
Hokamp K, Wolfe KH., PubCrawler: keeping up comfortably with PubMed and GenBank., Nucleic Acids Research, 32, (Web Server Issue), 2004, pW16 - W19
Hokamp K, Roche FM, Acab M, Rousseau ME, Kuo B, Goode D, Aeschliman D, Bryan J, Babiuk LA, Hancock RE, Brinkman FS., ArrayPipe: a flexible processing pipeline for microarray data., Nucleic Acids Research, 32, (Web Server Issue), 2004, pW457 - W459
Hokamp, K, Shields, DC, Wolfe, KH, Caffrey, DR, Wrapping up BLAST and other applications for use on Unix clusters., Bioinformatics , 19, (3), 2003, p441-442
Blanc, G, Hokamp, K, Wolfe, KH, A recent polyploidy superimposed on older large-scale duplications in the Arabidopsis genome., Genome research, 13, (2), 2003
Hokamp, K., McLysaght, A. and Wolfe, K. H., The 2R hypothesis and the human genome sequence., Journal of Structural and Functional Genomics, 3, (1-4), 2003, p95 - 110
McLysaght, A., Hokamp K, and Wolfe, K.H., Extensive genomic duplication during early chordate evolution, Nature Genetics, 31, (2), 2002, p200 - 204
Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J, Devon, K, Dewar, K, Doyle, M, FitzHugh, W, Funke, R, Gage, D, Harris, K, Heaford, A, Howland, J, Kann, L, Lehoczky, J, LeVine, R, McEwan, P, McKernan, K, Meldrim, J, Mesirov, JP, Miranda, C, Morris, W, Naylor, J, Raymond, C, Rosetti, M, Santos, R, Sheridan, A, Sougnez, C, Stange-Thomann, N, Stojanovic, N, Subramanian, A, Wyman, D, Rogers, J, Sulston, J, Ainscough, R, Beck, S, Bentley, D, Burton, J, Clee, C, Carter, N, Coulson, A, Deadman, R, Deloukas, P, Dunham, A, Dunham, I, Durbin, R, French, L, Grafham, D, Gregory, S, Hubbard, T, Humphray, S, Hunt, A, Jones, M, Lloyd, C, McMurray, A, Matthews, L, Mercer, S, Milne, S, Mullikin, JC, Mungall, A, Plumb, R, Ross, M, Shownkeen, R, Sims, S, Waterston, RH, Wilson, RK, Hillier, LW, McPherson, JD, Marra, MA, Mardis, ER, Fulton, LA, Chinwalla, AT, Pepin, KH, Gish, WR, Chissoe, SL, Wendl, MC, Delehaunty, KD, Miner, TL, Delehaunty, A, Kramer, JB, Cook, LL, Fulton, RS, Johnson, DL, Minx, PJ, Clifton, SW, Hawkins, T, Branscomb, E, Predki, P, Richardson, P, Wenning, S, Slezak, T, Doggett, N, Cheng, JF, Olsen, A, Lucas, S, Elkin, C, Uberbacher, E, Frazier, M, Gibbs, RA, Muzny, DM, Scherer, SE, Bouck, JB, Sodergren, EJ, Worley, KC, Rives, CM, Gorrell, JH, Metzker, ML, Naylor, SL, Kucherlapati, RS, Nelson, DL, Weinstock, GM, Sakaki, Y, Fujiyama, A, Hattori, M, Yada, T, Toyoda, A, Itoh, T, Kawagoe, C, Watanabe, H, Totoki, Y, Taylor, T, Weissenbach, J, Heilig, R, Saurin, W, Artiguenave, F, Brottier, P, Bruls, T, Pelletier, E, Robert, C, Wincker, P, Smith, DR, Doucette-Stamm, L, Rubenfield, M, Weinstock, K, Lee, HM, Dubois, J, Rosenthal, A, Platzer, M, Nyakatura, G, Taudien, S, Rump, A, Yang, H, Yu, J, Wang, J, Huang, G, Gu, J, Hood, L, Rowen, L, Madan, A, Qin, S, Davis, RW, Federspiel, NA, Abola, AP, Proctor, MJ, Myers, RM, Schmutz, J, Dickson, M, Grimwood, J, Cox, DR, Olson, MV, Kaul, R, Raymond, C, Shimizu, N, Kawasaki, K, Minoshima, S, Evans, GA, Athanasiou, M, Schultz, R, Roe, BA, Chen, F, Pan, H, Ramser, J, Lehrach, H, Reinhardt, R, McCombie, WR, de la Bastide, M, Dedhia, N, Blöcker, H, Hornischer, K, Nordsiek, G, Agarwala, R, Aravind, L, Bailey, JA, Bateman, A, Batzoglou, S, Birney, E, Bork, P, Brown, DG, Burge, CB, Cerutti, L, Chen, HC, Church, D, Clamp, M, Copley, RR, Doerks, T, Eddy, SR, Eichler, EE, Furey, TS, Galagan, J, Gilbert, JG, Harmon, C, Hayashizaki, Y, Haussler, D, Hermjakob, H, Hokamp, K, Jang, W, Johnson, LS, Jones, TA, Kasif, S, Kaspryzk, A, Kennedy, S, Kent, WJ, Kitts, P, Koonin, EV, Korf, I, Kulp, D, Lancet, D, Lowe, TM, McLysaght, A, Mikkelsen, T, Moran, JV, Mulder, N, Pollara, VJ, Ponting, CP, Schuler, G, Schultz, J, Slater, G, Smit, AF, Stupka, E, Szustakowski, J, Thierry-Mieg, D, Thierry-Mieg, J, Wagner, L, Wallis, J, Wheeler, R, Williams, A, Wolf, YI, Wolfe, KH, Yang, SP, Yeh, RF, Collins, F, Guyer, MS, Peterson, J, Felsenfeld, A, Wetterstrand, KA, Patrinos, A, Morgan, MJ, de Jong, P, Catanese, JJ, Osoegawa, K, Shizuya, H, Choi, S, Chen, YJ, Szustakowki, J, Initial sequencing and analysis of the human genome., Nature, 409, (6822), 2001
Galligan, L, Livingstone, W, Volkov, Y, Hokamp, K, Murphy, C, Lawler, M, Fukudome, K, Smith, O, Characterization of protein C receptor expression in monocytes., British journal of haematology, 115, (2), 2001
Hokamp, K, Wolfe, K, What's new in the library? What's new in GenBank? let PubCrawler tell you., Trends in genetics : TIG, 15, (11), 1999
Non-Peer-Reviewed Publications
Hokamp K, Perl One-Liners: Bridging the Gap Between Large Data Sets and Analysis Tools., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p177-191