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Professor Mark Little
Professor/Consultant of Nephrology, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Salama AD, A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis., Rheumatology (Oxford, England), 2019, p260-268 Journal Article, 2019 DOI

Gopaluni, S. and Flossmann, O. and Little, M.A. and O'Hara, P. and Bekker, P. and Jayne, D., Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term Outcomes in Antineutrophil Cytoplasmic Antibodyâ€"Associated Vasculitis, Arthritis and Rheumatology, 71, (5), 2019, p784-791 Journal Article, 2019 DOI

Dekkema GJ, Abdulahad WH, Bijma T, Moran SM, Ryan L, Little MA, Stegeman CA, Heeringa P, Sanders JF, Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019, p1039-1049 Journal Article, 2019 DOI

Pepper, R. and Jayne, D. and Little, M. and Pusey, C. and Salama, A.D., Comment on: A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis: Reply, Rheumatology (United Kingdom), 58, (4), 2019, p738-739 Journal Article, 2019 DOI

Connaughton DM, Kennedy C, Shril S, Mann N, Murray SL, Williams PA, Conlon E, Nakayama M, van der Ven AT, Itself H, Kause F, Kolvenbach CM, Dai R, Vivante A, Braun DA, Schneider R, Kitzler TM, Moloney B, Moran CP, Smyth JS, Kennedy A, Benson K, Stapleton C, Denton M, Magee C, O'Seaghdha CM, Plant WD, Griffin MD, Awan A, Sweeney C, Mane SM, Lifton RP, Griffin B, Leavey S, Casserly L, de Freitas DG, Holian J, Dorman A, Doyle B, Lavin PJ, Little MA. Conlon PJ, Hildebrandt F., Monogenic causes of chronic kidney disease in adults, Kidney International, 95, (4), 2019, p914 - 928 Journal Article, 2019 DOI

Canney M, Sexton DJ, O'Leary N, Healy M, Kenny RA, Little MA, O'Seaghdha CM, Examining the utility of cystatin C as a confirmatory test of chronic kidney disease across the age range in middle-aged and older community-dwelling adults., Journal of epidemiology and community health, 72, 2018, p287-293 Journal Article, 2018 URL

Ortiz-Fernández L, Carmona FD, López-Mejías R, González-Escribano MF, Lyons PA, Morgan AW, Sawalha AH, Smith KGC, González-Gay MA, Martín J, AAV Study group, Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis., Annals of the rheumatic diseases, 2018 Journal Article, 2018

Canney, M., Leahy, S., Scarlett, S., Kenny, R.A,, Little, M., O'Seaghdha, C., McCrory, C, Kidney disease in women is associated with disadvantaged childhood socioeconomic position, American Journal of Nephrology, 47, (5), 2018, p292 - 299 Journal Article, 2018 URL

Moran S. M., Monach P. A., Zgaga L., Cuthbertson D., Carette S., Khalidi N. A., Koening C. L., Langford C. A., McAlear C. A., Moreland L., Pagnoux C., Seo P., Specks U., Sreih A., Wyse J., Ytterberg S. R., Merkel P. A. and Little M. A., Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis, Nephrology Dialysis Transplantation, 2018, p1-9 Journal Article, 2018 DOI

Menez S, Hruskova Z, Scott J, Cormican S, Chen M, Salama AD, Alasfar S, Little MA, Safrankova H, Honsova E, Tesar V, Geetha D, Predictors of Renal Outcomes in Sclerotic Class Anti-Neutrophil Cytoplasmic Antibody Glomerulonephritis., American journal of nephrology, 2018 Journal Article, 2018 DOI

Geetha D, Jin Q, Scott J, Hruskova Z, Hanouneh M, Little MA, Tesar V, Seo P, Jayne D, Pagnoux C, Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody-Associated Vasculitis., Kidney international reports, 2018 Journal Article, 2018 DOI

Brian Reddy, Brett Houlding, Lucy Hederman, Mark Canney, Christophe Debruyne, Ciaran O'Brien, Alan Meehan, Declan O'Sullivan, Mark A Little,, Data linkage in medical science using the resource description framework: the AVERT model, HRB Open Research, 1, (20), 2018, p1-15 Journal Article, 2018 DOI TARA - Full Text URL

Canney, M. and Sexton, E. and Tobin, K. and Kenny, R.A. and Little, M.A. and O'Seaghdha, C.M., The relationship between kidney function and quality of life among community-dwelling adults varies by age and filtration marker, Clinical Kidney Journal, 11, (2), 2018, p259-264 Journal Article, 2018 TARA - Full Text DOI

Gopaluni S, Flossmann O, Little MA, O'Hara P, Bekker P, Jayne D, European Vasculitis Society, Effect of disease activity at three and six months on long-term outcomes in ANCA associated vasculitis., Arthritis & rheumatology (Hoboken, N.J.), 2018 Journal Article, 2018 DOI

O†Reilly, V.P. and Wong, L. and Kennedy, C. and Elliot, L.A. and O†Meachair, S. and Coughlan, A.M. and O†Brien, E.C. and Ryan, M.M. and Sandoval, D. and Connolly, E. and Dekkema, G.J. and Lau, J. and Abdulahad, W.H. and Sanders, J.-S.F. and Heeringa, P. and Buckley, C. and O†Brien, C. and Finn, S. and Cohen, C.D. and Lindemeyer, M.T. and Hickey, F.B. and O†Hara, P.V. and Feighery, C. and Moran, S.M. and Mellotte, G. and Clarkson, M.R. and Dorman, A.J. and Murray, P.T. and Little, M.A., Erratum: Urinary soluble CD163 in active renal vasculitis (Journal of the American Society of Nephrology (2016) 27 (2906-2916) DOI: 10.1681/ASN.2015050511), Journal of the American Society of Nephrology, 29, (8), 2018, p2255 Journal Article, 2018 DOI

Dearbhaile Dooley, Mirjan M. van Timmeren, Vincent P. O'Reilly, Gareth Brady, Eoin C. O'Brien, Barbara Fazekas, Fionnuala B. Hickey, Emma Leacy, Charles D. Pusey, Frederick W.K. Tam, Thomas Mehrling, Peter Heeringa and Mark A. Little, Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis, Kidney International, 2018 Journal Article, 2018 DOI

Novick, T.K. and Chen, M. and Scott, J. and Cortazar, F.B. and Ayoub, I. and Little, M.A. and Hruskova, Z. and Salama, A.D. and Pagnoux, C. and Geetha, D., Patient Outcomes in Renal-Limited Antineutrophil Cytoplasmic Antibody Vasculitis With Inactive Histology, Kidney International Reports, 3, (3), 2018, p671-676 Journal Article, 2018 DOI

King C, Harper L, Little M, The complications of vasculitis and its treatment., Best practice & research. Clinical rheumatology, 2018 Journal Article, 2018

Fazekas, B and Moreno-Olivera, A and Kelly, Y and O'Hara, P and Murray, S and Kennedy, A and Conlon, N and Scott, J and Melo, AM and Hickey, FB and Dooley, D and O'Brien, EC and Moran, S and Doherty, DG and Little, MA, Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury, Clinical and experimental immunology, 191, (2), 2018, p180â€"188 Journal Article, 2018 DOI

Sexton, D.J. and de Freitas, D.G. and Little, M.A. and McHugh, T. and Magee, C. and Conlon, P.J. and O'Seaghdha, C.M., Direct-Acting Oral Anticoagulants as Prophylaxis Against Thromboembolism in the Nephrotic Syndrome, Kidney International Reports, 3, (4), 2018, p784-793 Journal Article, 2018 DOI

Lyons P, Peters J, Alberici F, Liley J, Coulson R, Astle W, Baldini C, Bonatti F, Cid M, Elding H, Emmi G, Epplen J, Guillevin L, Jayne DR, Jiang T, The European Vasculitis Genetics Consortium, Genetically distinct clinical subsets, and associations with asthma and eosinophil abundance, within Eosinophilic Granulomatosis with Polyangiitis, 2018 Journal Article, 2018 URL DOI

Canney M, Little MA, ANCA in anti-GBM disease: moving beyond a one-dimensional clinical phenotype., Kidney international, 923, 2017, p44-546 Review Article, 2017 URL

Tobin, Laura M and Mavinkurve, Meenal and Carolan, Eirin and Kinlen, David and O'Brien, Eoin C and Little, Mark A and Finlay, David K and Cody, Declan and Hogan, Andrew E and O'Shea, Donal, NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient, JCI insight, 2, (24), 2017, pe94939 Journal Article, 2017 DOI

Yates M, Watts R, Bajema I, Cid M, Crestani B, Hauser T, Hellmich B, Holle J, Laudien M, Little MA, Luqmani RA, Mahr A, Merkel P, Mills J, Mooney J, Mukhtyar C, Validation of the EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis by disease content experts., RMD open, 3, 2017, pe000449 Journal Article, 2017 URL

Canney M, O'Connell MDL, Sexton DJ, O'Leary N, Kenny RA, Little MA, O'Seaghdha CM, Graded Association Between Kidney Function and Impaired Orthostatic Blood Pressure Stabilization in Older Adults, Journal of the American Heart Association, 6, 2017, pe005661 Journal Article, 2017 DOI TARA - Full Text

Bajema IM, Bruijn JA, Casian A, Cid MC, Csernok E, van Daalen E, Harper L, Hauser T, Little MA, Luqmani RA, Mahr A, Ponte C, Salama A, Segelmark M, Jayne D, The European Vasculitis Society 2016 Meeting Report., Kidney International Reports, 26, 2017, p1018-1031. Journal Article, 2017

Canney M, Sexton DJ, O'Connell MD, Kenny RA, Little MA, O'Seaghdha CM, Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults, The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 2017, p1554-1560 Journal Article, 2017 DOI

Sexton DJ, Canney M, O'Connell MDL, Moore P, Little MA, O'Seaghdha CM, Kenny RA, Injurious Falls and Syncope in Older Community-Dwelling Adults Meeting Inclusion Criteria for SPRINT., JAMA internal medicine, 177, 2017, p1385- Journal Article, 2017 URL

Popat RJ, Hakki S, Thakker A, Coughlan AM, Watson J, Little MA, Spickett CM, Lavender P, Afzali B, Kemper C, Robson MG., Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development., JCI insight, 2, (2), 2017, pe87379 Journal Article, 2017 TARA - Full Text DOI

Yates M, Watts R.A, Bajema I.M, Cid M.C, Crestani B, Hauser T, Hellmich B, Holle J.U, Laudien M, Little M.A, Luqmani R.A, Mahr A, Merkel P.A, Mills J, Mooney J, Segelmark M, Tesar V, Westman K, Vaglio A, Yalçlndaǧ N, Jayne D.R, Mukhtyar C, EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis, Annals of the Rheumatic Diseases, 75, (9), 2016, p1583 - 1594 Journal Article, 2016 DOI URL

Canney M, O'Hara PV, McEvoy CM, Medani S, Connaughton DM, Abdalla AA, Doyle R, Stack AG, O'Seaghdha CM, Clarkson MR, Griffin MD, Holian J, Dorman AM, Niland A, Keogan M, Wallace EM, Conlon NP, Walsh C, Kelly A, Little MA., Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease., Clinical journal of the American Society of Nephrology : CJASN, 11, (8), 2016, p1392-1399 Journal Article, 2016 DOI

Canney M, O'Connell MD, Murphy CM, O'Leary N, Little MA, O'Seaghdha CM, Kenny RA, Single Agent Antihypertensive Therapy and Orthostatic Blood Pressure Behaviour in Older Adults Using Beat-to-Beat Measurements: The Irish Longitudinal Study on Ageing., PloS one, 11, (1), 2016, pe0146156 Journal Article, 2016 TARA - Full Text DOI

Oomatia A, Moran S.M, Kennedy C, Sequeira R, Hamour S, Burns A, Little M.A, Salama A.D, Prolonged Duration of Renal Recovery Following ANCA-Associated Glomerulonephritis, American Journal of Nephrology, 43, (2), 2016, p112 - 119 Journal Article, 2016 URL DOI

O'Reilly VP, Wong L, Kennedy C, Elliot LA, O'Meachair S, Coughlan AM, O'Brien EC, Ryan MM, Sandoval D, Connolly E, Dekkema GJ, Lau J, Abdulahad WH, Sanders JS, Heeringa P, Buckley C, O'Brien C, Finn S, Cohen CD, Lindemeyer MT, Hickey FB, O'Hara PV, Feighery C, Moran SM, Mellotte G, Clarkson MR, Dorman AJ, Murray PT, Little MA., Urinary Soluble CD163 in Active Renal Vasculitis., Journal of the American Society of Nephrology, 27, (9), 2016, p2906 - 2916 Journal Article, 2016 DOI URL

MÞller HJ, Tesar V, Little MA., Urine sCD163: a window onto glomerular inflammation., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 31, (12), 2016, p1970-1972 Journal Article, 2016 DOI

Coughlan A.M, Harmon C, Whelan S, O'Brien E.C, O'Reilly V.P, Crotty P, Kelly P, Ryan M, Hickey F.B, O'Farrelly C, Little M.A, Myeloid engraftment in humanized mice: Impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain, Stem Cells and Development, 25, (7), 2016, p530 - 541 Journal Article, 2016 URL DOI

Rezk T, Penton J, Stevenson A, Owen-Casey M, Little M, Cunningham J, Salama A.D, Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria, BMC Nephrology, 17, (1), 2016, p49- Journal Article, 2016 URL DOI TARA - Full Text

Göçeroglu A, Rahmattulla C, Berden A.E, Reinders M.E.J, Wolterbeek R, Steenbergen E.J, Hilbrands L.B, Noorlander I, Berger S.P, Peutz-Kootstra C.J, Christiaans M.H.L, Van Dijk M.C.R.F, De Joode A.A.E, Goldschmeding R, Van Zuilen A.D, Harper L, Little M.A, Christiaan Hagen E, Bruijn J.A, Bajema I.M, The Dutch transplantation in vasculitis (DUTRAVAS) study: Outcome of renal transplantation in antineutrophil cytoplasmic antibody-associated glomerulonephritis, Transplantation, 100, (4), 2016, p916 - 924 Journal Article, 2016 DOI URL

Al-Ani B, Fitzpatrick M, Al-Nuaimi H, Coughlan A.M, Hickey F.B, Pusey C.D, Savage C, Benton C.M, O'Brien E.C, O'Toole D, Mok K.H, Young S.P, Little M.A, Changes in urinary metabolomic profile during relapsing renal vasculitis, Scientific Reports, 6, 2016, 38074 - Journal Article, 2016 TARA - Full Text DOI URL

Wong L, Harper L, Little MA, Getting the balance right: adverse events of therapy in anti-neutrophil cytoplasm antibody vasculitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30 Suppl 1, 2015, p164 - 170 Journal Article, 2015 TARA - Full Text

Kelly, Yvelynne P., Moran, Sarah M., Kelly, Dearbhla M., Wong, Limy, Little, Mark A., Clarkson, Michael R., ANCA AND ANTI-GBM DOUBLE POSITIVITY: ACASE SERIES, Nephrology Dialysis Transplantation, 30, 2015 Journal Article, 2015

O'Brien EC, Abdulahad WH, Rutgers A, Huitema MG, O'Reilly VP, Coughlan AM, Harrington M, Heeringa P, Little MA, Hickey FB, Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1ß secretion in response to anti-MPO antibodies., Scientific reports, 5, 2015, p11888 - Journal Article, 2015 DOI TARA - Full Text URL

Turner-Stokes T, Sandhu E, Pepper R.J, Salama A.D, Burns A, Little M.A, Comment on: Induction treatment of ANCA-associated vasculitis with a single dose of rituximab: Reply, Rheumatology (United Kingdom), 54, (2), 2015, p373 - 374 Journal Article, 2015 DOI URL

Connaughton DM, Bukhari S, Conlon P, Cassidy E, O'Toole M, Mohamad M, Flanagan J, Butler T, O'Leary A, Wong L, O'Regan J, Moran S, O'Kelly P, Logan V, Griffin B, Griffin M, Lavin P, Little MA, Conlon P, The Irish Kidney Gene Project - Prevalence of Family History in Patients with Kidney Disease in Ireland., Nephron, 130, (4), 2015, p293-301 Journal Article, 2015 DOI

Salama A.D, Little M.A, The janus faces of IL-6 in GN, Journal of the American Society of Nephrology, 26, (7), 2015, p1480 - 1482 Journal Article, 2015 URL DOI

Salama, A. D., Little, M. A., The Janus Faces of IL-6 in GN, J Am Soc Nephrol, 26, (7), 2015, p1480-2 Journal Article, 2015

Basu,Neil N., Mcclean,Andrew A., Harper,Lorraine L., Amft,Esther Nicole E.N., Dhaun,Neeraj N., Luqmani,R. A. R.A., Little,Mark Alan M.A., Jayne,David Rw W D.R.W., Floà mann,Oliver O., Mclaren,John S. J.S., Kumar,Vinod Mutyala V.M., Erwig,Lars Peter L.P., Reid,David M. D.M., Jones,Gareth T. G.T., Macfarlane,Gary J. G.J., The characterisation and determinants of quality of life in ANCA associated vasculitis, Annals of the Rheumatic Diseases, 73, (1), 2014, p207-211 Journal Article, 2014 DOI TARA - Full Text

Animal Models of ANCA Vasculitis in, editor(s)Aman Sharma , Textbook of vasculitis, India, Jaypee publishers, 2014, pp35-40 , [Mark Little, Alice Coughlan] Book Chapter, 2014 URL

Redahan L, Doyle R, O'Shaughnessy M, Dorman A, Little M, Conlon P, Familial MPGN- A case series: A clinical description of familial membranoproliferative glomerulonephritis amongst three Irish families, Renal Failure, 36, (8), 2014, p1333 - 1336 Journal Article, 2014 DOI URL

Tabitha Turner-Stokes, Eleanor Sandhu, Ruth J. Pepper, Natalie E. Stolagiewicz, Caroline Ashley, Deirdre Dinneen, Alexander J. Howie, Alan D. Salama, Aine Burns and Mark A. Little, Induction treatment of ANCA-associated vasculitis with a single dose of rituximab., Rheumatology, 53, (8), 2014, p1395-403 Journal Article, 2014 DOI TARA - Full Text

Experimental autoimmune vasculitis: Insights into human vasculitis using animal models in, editor(s) , The Vasculitides, Nova Science Publishers, Inc., 2014, pp85 - 94, [Salama, A.D., Little, M.A.] Book Chapter, 2014

Basu N, McClean A, Harper L, Amft EN, Dhaun N, Luqmani RA, Little MA, Jayne DR, Flossmann O, McLaren J, Kumar V, Erwig LP, Reid DM, Macfarlane GJ, Jones GT., Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis., Rheumatology, 53, (5), 2014, p953-6 Journal Article, 2014 TARA - Full Text DOI

Turner-Stokes,Tabitha T., Sandhu,Eleanor E., Pepper,Ruth J. R.J., Stolagiewicz,Natalie E. N.E., Ashley,Caroline C., Dinneen,Deirdre D., Howie,Alexander J. A.J., Salama,Alan D. A.D., Burns,Ã ine P. A.P., Little,Mark Alan M.A., Induction treatment of ANCA-associated vasculitis with a single dose of rituximab, Rheumatology (United Kingdom), 53, (8), 2014, p1397-1403 Journal Article, 2014 DOI TARA - Full Text

Moran,Sarah Margaret S.M., Little,Mark Alan M.A., Renal transplantation in antineutrophil cytoplasmic antibody-associated vasculitis, Current Opinion in Rheumatology, 26, (1), 2014, p37-41 Journal Article, 2014 DOI

Sznajd, Jan, Salama, Alan D., Jayne, David, Chaudhry, Afzal, Robson, Michael, Rosa, Joe, Basu, Neil, Moran, Sarah, Venning, Michael, Lanyon, Peter, Sharma, Asheesh, Little, Mark A., Watts, Richard, Luqmani, Raashid, United Kingdom & Ireland Vasculitis Registry - Cross-Sectional Data on the First 1085 Patients, Arthritis & Rheumatology, 66, 2014, pS773 Journal Article, 2014

Little, Mark A., Animal models of PR3-ANCA vasculitis: Approaches and controversies, Presse Medicale, 42, (4), 2013, p512-515 Journal Article, 2013

Goceroglu, A., Rahmattulla, C., Berden, A. E., Reinders, M., Van Dijk, M. C. R. F., De Joode, A. A. E., Peutz-Kootstra, C. J., Christiaans, M. H. L., Noorlander, I., Goldschmeding, R., Van Zuilen, A. D., Steenbergen, E. J., Hilbrands, L. B., Harper, L., Little, M. A., Hagen, E. C., Bruijn, J. A., Bajema, I. M., Dutch transplantation in vasculitis (DUTRAVAS)-study: Update on the outcome of renal transplantation in ANCA-associated vasculitis (AAV) patients in the Netherlands, Presse Medicale, 42, (4), 2013, p658-659 Journal Article, 2013

Pepper RJ, Chanouzas D, Tarzi R, Little MA, Casian A, Walsh M, Pusey CD, Harper L, Salama AD, Intravenous Cyclophosphamide and Plasmapheresis in Dialysis-Dependent ANCA-Associated Vasculitis, Clincal Journal of the American Society of Nephrology, 8, (2), 2013, p219 - 224 Journal Article, 2013 URL TARA - Full Text

Mcdaid, J. P., Tanna, A., Bhangal, G., Little, M. A., Behmoaras, J., Cook, H. T., Tam, F. W., Salama, A. D., Pusey, C. D., The role of quantitative trait loci (QTL) in the pathogenesis of experimental autoimmune vasculitis (EAV), Presse Medicale, 42, (4), 2013, p688 Journal Article, 2013

Little,Mark Alan M.A., L7. Animal models of PR3-ANCA vasculitis: Approaches and controversies, Presse Medicale, 42, (4 PART2), 2013, p512-515 Journal Article, 2013 DOI

Pepper, R. J., Chanouzas, D., Tarzi, R., Little, M. A., Casian, Alina, Walsh, M., Pusey, C. D., Harper, L., Salama, A. D., European Vasculitis Study (EUVAS) investigators: Intravenous cyclophosphamide and plasmapheresis in dialysis-dependent ANCA-associated vasculitis (vol 8, pg 219, 2013), Clinical Journal of the American Society of Nephrology, 8, (4), 2013, p701 Journal Article, 2013

Basu,Neil N., Mcclean,Andrew A., Harper,Lorraine L., Amft,Esther Nicole E.N., Dhaun,Neeraj N., Luqmani,R. A. R.A., Little,Mark Alan M.A., Jayne,David Rw W D.R.W., Floà mann,Oliver O., Mclaren,John S. J.S., Kumar,Vinod Mutyala V.M., Erwig,Lars Peter L.P., Reid,David M. D.M., Macfarlane,Gary J. G.J., Jones,Gareth T. G.T., Explaining fatigue in ANCA-associated vasculitis, Rheumatology (United Kingdom), 52, (9), 2013, p1680-1685 Journal Article, 2013 DOI TARA - Full Text

The kidney in, editor(s)Richard Watts , Oxford Textbook of Rheumatology (4th Ed), Oxford, UK, Oxford University Press, 2013, pp185-194 , [Mark Little, Alan Salama] Book Chapter, 2013 URL

Basu, Neil, McClean, Andrew, Harper, Lorraine, Amft, Esther N., Dhaun, Neeraj, Luqmani, Raashid A., Little, Mark A., Jayne, David R., Flossmann, Oliver, McLaren, John, Kumar, Vinod, Reid, David M., Macfarlane, Gary J., Jones, Gareth, EXPLAINING FATIGUE IN ANCA-ASSOCIATED VASCULITIS, Rheumatology, 52, 2013, p170 Journal Article, 2013

Little MA, Al-Ani B, Ren S, Al-Nuaimi H, Leite M, Alpers CE, Savage CO, Duffield JS, Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system., PloS one, 7, (1), 2012, pe28626 Journal Article, 2012 TARA - Full Text

Kiprianos AP, Morgan MD, Little MA, Harper L, Bacon PA, Young SP, Elevated active secretory sphingomyelinase in antineutrophil cytoplasmic antibody-associated primary systemic vasculitis., Annals of the rheumatic diseases, 71, 2012, p1100 - 1102 Journal Article, 2012

Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hru"ková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesa" V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG, Genetically Distinct Subsets within ANCA-Associated Vasculitis., The New England journal of medicine, 367, (3), 2012, p214-23 Journal Article, 2012

Hong, Y, Eleftheriou, D, Hussain, AAK, Price-Kuehne, FE, Savage, CO, Jayne, D, Little, MA, Salama, AD, Klein, NJ, Brogan, PA, Anti-Neutrophil Cytoplasmic Antibodies Stimulate Release of Neutrophil Microparticles, JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 23, 2012, p49 - 62 Journal Article, 2012 TARA - Full Text

Salama AD, Little MA, Animal models of antineutrophil cytoplasm antibody-associated vasculitis., Current opinion in rheumatology, 24, (1), 2012, p1-7 Journal Article, 2012

Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S, Fortuitous Vasculitis., Renal failure, 34, 2012 Journal Article, 2012

Moore, J, He, X, Shabir, S, HanvesakulPhd, R, Benavente, D, Cockwell, P, Little, MA, Ball, S, Inston, N, Johnston, A, Borrows, R, Development and Evaluation of a Composite Risk Score to Predict Kidney Transplant Failure, AMERICAN JOURNAL OF KIDNEY DISEASES, 57, 2011 Journal Article, 2011

Mansur, A, Little, MA, Oh, WC, Jacques, S, Nightingale, P, Howie, AJ, Savage, COS, Immune Profile and Epstein-Barr Virus Infection in Acute Interstitial Nephritis: An Immunohistochemical Study in 78 Patients, NEPHRON CLINICAL PRACTICE, 119, 2011 Journal Article, 2011

Heeringa P, Little MA, In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations., Arthritis research & therapy, 13, (1), 2011, p204 Journal Article, 2011

Al-Ani, Bahjat, Al Nuaimi, Hamad, Savage, Caroline, Little, Mark A., The Beneficial Effects of Statin Therapy May Not Apply to All Forms of Crescentic Glomerulonephritis, American Journal of Pathology, 178, (5), 2011, p2447 Journal Article, 2011

Suppiah, R, Mukhtyar, C, Flossmann, O, Alberici, F, Baslund, B, Batra, R, Brown, D, Holle, J, Hruskova, Z, Jayne, DRW, Judge, A, Little, MA, Palmisano, A, Stegeman, C, Tesar, V, Vaglio, A, Westman, K, Luqmani, R, A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis, RHEUMATOLOGY, 50, 2011 Journal Article, 2011

Suppiah, R, Flossmann, O, Mukhtyar, C, Alberici, F, Baslund, B, Brown, D, Hasan, N, Holle, J, Hruskova, Z, Jayne, D, Judge, A, Little, MA, Merkel, PA, Palmisano, A, Seo, P, Stegeman, C, Tesar, V, Vaglio, A, Westman, K, Luqmani, R, Measurement of damage in systemic vasculitis: a comparison of the Vasculitis Damage Index with the Combined Damage Assessment Index, ANNALS OF THE RHEUMATIC DISEASES, 70, 2011 Journal Article, 2011

Goceroglu, A., Berden, A. E., van Dijk, M. C. R. F., de Joode, A. A. E., Peutz-Kootstra, C. J., Christiaans, M. H. L., Smedts, F. M. M., Noorlander, I., Goldschmeding, R., van Zuilen, A., Steenbergen, E. J., Hilbrands, L. B., Reinders, M., Harper, L., Little, M. A., Hagen, E. C., Bruijn, J. A., Bajema, I. M., Dutch Transplantation in Vasculitis Study (DUTRAVAS): a multi-centre study on the outcome of renal transplantation in ANCA-AAV patients, Clinical and Experimental Immunology, 164, 2011, p101 Journal Article, 2011

Al-Ani, Bahjat, Al Nuaimi, Hamad, Smith, Stuart, Young, Stephen P., Savage, Caroline, Little, Mark A., Remission, relapse and renal scarring in EAV, Clinical and Experimental Immunology, 164, 2011, p124 Journal Article, 2011

Moore, J, He, XA, Liu, XA, Shabir, S, Ball, S, Cockwell, P, Inston, N, Little, MA, Johnston, A, Borrows, R, Mortality Prediction After Kidney Transplantation: Comparative Clinical Use of 7 Comorbidity Indices, EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 9, 2011 Journal Article, 2011

Basu, N, Watts, R, Bajema, I, Baslund, B, Bley, T, Boers, M, Brogan, P, Calabrese, L, Cid, MC, Cohen-Tervaert, JW, Flores-Suarez, LF, Fujimoto, S, de Groot, K, Guillevin, L, Hatemi, G, Hauser, T, Jayne, D, Jennette, C, Kallenberg, CGM, Kobayashi, S, Little, MA, Mahr, A, McLaren, J, Merkel, PA, Ozen, S, Puechal, X, Rasmussen, N, Salama, A, Salvarani, C, Savage, C, Scott, DGI, Segelmark, M, Specks, U, Sunderkoetter, C, Suzuki, K, Tesar, V, Wiik, A, Yazici, H, Luqmani, R, EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis, ANNALS OF THE RHEUMATIC DISEASES, 69, 2010 Journal Article, 2010

Little, MA, Nightingale, P, Verburgh, CA, Hauser, T, De Groot, K, Savage, C, Jayne, D, Harper, L, Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis, ANNALS OF THE RHEUMATIC DISEASES, 69, 2010 Journal Article, 2010

Little, MA, Hassan, B, Jacques, S, Game, D, Salisbury, E, Courtney, AE, Brown, C, Salama, AD, Harper, L, Renal transplantation in systemic vasculitis: when is it safe?, NEPHROLOGY DIALYSIS TRANSPLANTATION, 24, 2009 Journal Article, 2009

Moore, Jason, Liu, Xiang, He, Xiang, Shabir, Shazia, Ball, Simon, Cockwell, Paul, Inston, Nicholas, Little, Mark A., Borrows, Richard, Johnston, Atholl, Impact of Comorbidity on Mortality Following Renal Transplantation: Comparative Clinical Utility of Seven Scoring Systems., American Journal of Transplantation, 9, 2009, p593 Journal Article, 2009

Moore, J, Middleton, L, Cockwell, P, Adu, D, Ball, S, Little, MA, Ready, A, Wheatley, K, Borrows, R, Calcineurin Inhibitor Sparing With Mycophenolate in Kidney Transplantation: A Systematic Review and Meta-Analysis, TRANSPLANTATION, 87, 2009 Journal Article, 2009

Little, MA, Smyth, L, Salama, AD, Mukherjee, S, Smith, J, Haskard, D, Nourshargh, S, Cook, HT, Pusey, CD, Experimental Autoimmune Vasculitis An Animal Model of Anti-neutrophil Cytoplasmic Autoantibody-Associated Systemic Vasculitis, AMERICAN JOURNAL OF PATHOLOGY, 174, 2009 Journal Article, 2009 TARA - Full Text

Moore, J, Ramakrishna, S, Tan, K, Cockwell, P, Eardley, K, Little, MA, Rylance, P, Shivakurnar, K, Suresh, V, Tomlinson, K, Ready, A, Borrows, R, Identification of the Optimal Donor Quality Scoring System and Measure of Early Renal Function in Kidney Transplantation, TRANSPLANTATION, 87, 2009 Journal Article, 2009

He, Xiang, Moore, Jason, Liu, Xiang, Shabir, Shazia, Cockwell, Paul, Little, Mark A., Ball, Simon, Inston, Nicholas, Johnston, Atholl, Borrows, Richard, A Simple "Kidney Risk Score" (KRS) and "Mortality Risk Score" (MRS) for Renal Transplant Recipients., American Journal of Transplantation, 9, 2009, p428 Journal Article, 2009

Kai, Anneke, Espinel-Costoso, Laura, Trivedi, Sapna, Casal, Ali, Morgan, Matthew, Levy, Jeremy, Little, Mark A., Pusey, Charles, Jayne, David, Salama, Alan D., Outcomes of a UK cohort of AAV patients treated with TNF blockade, Apmis, 117, 2009, p74 Journal Article, 2009

Pankhurst, Tanya, Savage, Caroline O. S., Little, Mark A., Review article: Leukocyte-endothelial dysregulation in systemic small vessel vasculitis, Nephrology, 14, (1), 2009, p3-10 Journal Article, 2009

He, X, Moore, J, Shabir, S, Little, MA, Cockwell, P, Ball, S, Liu, X, Johnston, A, Borrows, R, Comparison of the Predictive Performance of eGFR Formulae for Mortality and Graft Failure in Renal Transplant Recipients, TRANSPLANTATION, 87, 2009 Journal Article, 2009

Wong, C. F., Little, M. A., Vinjamuri, S., Hammad, A., Harper, J. M., Technetium myocardial perfusion scanning in prerenal transplant evaluation in the United Kingdom, Transplantation Proceedings, 40, (5), 2008, p1324-1328 Journal Article, 2008

Winstanley, V, Little, MA, Wadsworth, C, Cohen, P, Martin, NM, The McKittrick-Wheelock syndrome: A case of acute renal failure due to neoplastic cholera, RENAL FAILURE, 30, 2008 Journal Article, 2008

Nathani, N, Little, MA, Kunst, H, Wilson, D, Thickett, DR, Churg-Strauss syndrome and leukotriene antagonist use: a respiratory perspective, THORAX, 63, 2008 Journal Article, 2008

Little, M. A., Savage, C. O. S., The role of the endothelium in systemic small vessel vasculitis, Clinical and Experimental Rheumatology, 26, (3), 2008, pS135-S140 Journal Article, 2008

Moore, J, He, X, Cockwell, P, Little, MA, Johnston, A, Borrows, R, The impact of hemoglobin levels on patient and graft survival in renal transplant recipients, TRANSPLANTATION, 86, 2008 Journal Article, 2008

Little MA, Hussein T, Lambert M, Dickson SJ, Percutaneous venepuncture practice in a large urban teaching hospital., Clinical medicine (London, England), 7, (3), 2007, p243-9 Journal Article, 2007

Malik AR, Little MA, Henriksson M, Tam FW, Brown EA, Peritonitis, peritoneal inflammation and membrane permeability: a longitudinal study of dialysate and serum MCP-1 in stable patients on peritoneal dialysis., Journal of nephrology, 20, (3), 2007, p340-9 Journal Article, 2007

Little, M A, Current and future therapy of small vessel vasculitis of the kidney., Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 58, (1), 2006, p39-52 Journal Article, 2006

Little MA, Dupont P, Campbell E, Dorman A, Walshe JJ, Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence risk., Kidney international, 69, (3), 2006, p504-11 Journal Article, 2006

Little MA, Bhangal G, Smyth CL, Nakada MT, Cook HT, Nourshargh S, Pusey CD, Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis., Journal of the American Society of Nephrology : JASN, 17, (1), 2006, p160-9 Journal Article, 2006 TARA - Full Text DOI

Ambrose, LR, Smith, LM, Little, MA, Dupont, PJ, Herbert, PE, Williams, G, Lombardi, G, Warrens, AN, PMNs as APCs in transplantation: bridging innate and adaptive immunity, Immunology, 116, 2005, p48 Journal Article, 2005

Little, MA, Pusey, CD, Nourshargh, S, Intravital microscopy in the study of ANCA-associated systemic vasculitis, Clinical Nephrology, 64, (6), 2005, p465-470 Journal Article, 2005

Little, MA, Pusey, CD, Glomerulonephritis due to antineutrophil cytoplasm antibody-associated vasculitis: An update on approaches to management, Nephrology, 10, (4), 2005, p368-376 Journal Article, 2005

Little, MA, Cafferky, M, Menon, S, Farrington, K, Dialysis amyloid: the bottom line, Nephrology Dialysis Transplantation, 20, (2), 2005, p462-463 Journal Article, 2005

Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, Pusey CD, Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo., Blood, 106, (6), 2005, p2050-8 Journal Article, 2005 DOI TARA - Full Text

Ambrose, LR, Little, MA, Nourshargh, S, Pusey, CD, Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy, Kidney International, 68, (6), 2005, p2912-2913 Journal Article, 2005

Little MA, Nazar L, Farrington K, Polymyalgia rheumatica preceding small-vessel vasculitis: changed spots or misdiagnosis?, QJM : monthly journal of the Association of Physicians, 97, (5), 2004, p289-92 Journal Article, 2004

Little MA, Nazar L, Farrington K, Outcome in glomerulonephritis due to systemic small vessel vasculitis: effect of functional status and non-vasculitic co-morbidity., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19, (2), 2004, p356-64 Journal Article, 2004

Little, MA, Pusey, CD, Rapidly progressive glomerulonephritis: Current and evolving treatment strategies, Journal of Nephrology, 17, 2004, pS10-S19 Journal Article, 2004

Little MA, Pusey CD., Rapidly progressive glomerulonephritis: current and evolving treatment strategies., Journal of nephrology, 17 Suppl 8, 2004, pS10-9 Journal Article, 2004 DOI

Gandhi S, Little MA, Farrington K, Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome., Renal failure, 26, (5), 2004, p591-6 Journal Article, 2004

Little, MA, Nazar, L, Farrington, K, Outcome in glomerulonephritis due to ANCA-associated small vessel vasculitis effect of functional status and non-vasculitic co-morbidity., Journal of the American Society of Nephrology, 14, 2003, p757A Journal Article, 2003

Smyth, C. L., Little, M. A., Cook, T., Smith, J., Haskard, D., Pusey, C. D., Time course of development of vasculitis in a rat model of ANCA-associated experimental autoimmune vasculitis., Kidney & Blood Pressure Research, 26, (4), 2003, p262-263 Journal Article, 2003

Little MA, O'Brien E, Owens P, Holian J, Kenny S, Mee F, Walshe JJ, A longitudinal study of the yield and clinical utility of a specifically designed secondary hypertension investigation protocol., Renal failure, 25, (5), 2003, p709-17 Journal Article, 2003

Williams A, Little M, Gibbs J, Warwicker P, Farrington K., Spinal cord infarction following central-line insertion., Renal failure, 25, (2), 2003, p327-329 Journal Article, 2003 DOI

Little, MA, Smyth, L, Buchatska, O, Bhangal, G, Wang, S, Nourshargh, S, Pusey, CD, Comparison of the binding characteristics of ANCA from vasculitic patients with ANCA from a novel rat model of systemic vasculitis., Journal of the American Society of Nephrology, 14, 2003, p414A Journal Article, 2003

Little MA, Walshe JJ, A longitudinal study of the repeated use of alteplase as therapy for tunneled hemodialysis catheter dysfunction., American journal of kidney diseases : the official journal of the National Kidney Foundation, 39, (1), 2002, p86-91 Journal Article, 2002

Donne, RL, Abbs, I, Barany, P, Elinder, CG, Little, M, Conlon, P, Goodship, THJ, Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor, American Journal of Kidney Diseases, 40, (6), 2002 Journal Article, 2002

McEntagart M, Parsons G, Buj-Bello A, Biancalana V, Fenton I, Little M, Krawczak M, Thomas N, Herman G, Clarke A, Wallgren-Pettersson C, Genotype-phenotype correlations in X-linked myotubular myopathy., Neuromuscular disorders : NMD, 12, (10), 2002, p939-46 Journal Article, 2002

Little MA, O'Riordan A, Lucey B, Farrell M, Lee M, Conlon PJ, Walshe JJ, A prospective study of complications associated with cuffed, tunnelled haemodialysis catheters., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16, (11), 2001, p2194-200 Journal Article, 2001

Conlon PJ, Little MA, Pieper K, Mark DB, Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography., Kidney international, 60, (4), 2001, p1490-7 Journal Article, 2001

Abraham KA, Little MA, Dorman AM, Walshe JJ, Hemolytic-uremic syndrome in association with both cyclosporine and tacrolimus., Transplant international : official journal of the European Society for Organ Transplantation, 13, (6), 2000, p443-7 Journal Article, 2000

Little MA, Dorman A, Gill D, Walshe JJ, Mesangioproliferative glomerulonephritis with IgM deposition: clinical characteristics and outcome., Renal failure, 22, (4), 2000, p445-57 Journal Article, 2000

Little MA, Stafford Johnson DB, O'Callaghan JP, Walshe JJ, The diagnostic yield of intravenous urography., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 15, (2), 2000, p200-4 Journal Article, 2000

Little MA, Conlon PJ, Walshe JJ, Access recirculation in temporary hemodialysis catheters as measured by the saline dilution technique., American journal of kidney diseases : the official journal of the National Kidney Foundation, 36, (6), 2000, p1135-9 Journal Article, 2000 DOI

Abraham KA, Little MA, Casey R, Smyth E, Walshe JJ, A novel presentation of cryptococcal infection in a renal allograft recipient., Irish medical journal, 93, (3), 2000, p82-4 Journal Article, 2000

Little MA, Abraham KA, Kavanagh J, Connolly G, Byrne P, Walshe JJ, Pregnancy in Irish renal transplant recipients in the cyclosporine era., Irish journal of medical science, 169, (1), 2000, p19-21 Journal Article, 2000

Research Expertise


I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. We are addressing the following questions: 1. What biomarkers accurately track glomerular and extra-renal inflammation in ANCA associated vasculitis? 2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult? 3. What underpins the large variability in clinical phenotype observed in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.


  • Title
    • HELICAL - Health Data Linkage for Clinical Benefit
  • Summary
    • HEalth data LInkage for ClinicAL benefit is a training network comprising 17 academic and 9 non-academic/industry partners for early stage researchers in the field of Healthcare Data Linkage in the GDPR era. European researchers have made leading contributions to the large genomic, transcriptomic and clinical datasets from patients with chronic diseases. Advances in information science provide unprecedented opportunities for using these datasets to elucidate the complex biology of these disorders, its influence by environmental triggers, and to personalise their management. Exploitation of these opportunities is limited by a shortage of researchers with the required informatics skills and knowledge of requisite data protection principles. HELICAL addresses this unmet need by developing a trans-sectoral and interdisciplinary programme with training in analysis of large datasets, using autoimmune vasculitis as a paradigm, as comprehensive biological and clinical datasets are already available. The programme will be delivered through a partnership of Academic and Industry researchers with expertise in basic biomedical research, epidemiology, statistics, machine learning, health data governance and ethics. HELICAL exploits recent advances in data science to link research datasets with longitudinal healthcare records, based on the robust ethical foundation required for linkage studies using near-patient data, to address key experimental questions.
  • Funding Agency
    • EU
  • Date From
    • 1/1/19
  • Date To
    • 31/12/23
  • Title
    • AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
  • Summary
    • We propose a new way of managing chronic diseases that brings the fields of medicine and data science together. We hypothesise that the interaction between individuals with the relapsing and remitting autoimmune kidney disease ANCA vasculitis, and their environment, can be detected and defined by observing the whole system in action and integrating a wide array of data sources. Collaboration with IBM will allow us to take advantage of recent advances in machine learning technology that allows iterative refinement of algorithms to generate a technology readiness level 3 proof of concept physician tool, to present analysis results in a clinically meaningful way. The ultimate goal of this approach is to define the signature of vasculitis relapse and use this to aid in planning and delivery of optimum immunosuppressive therapy at the level of the patient. To achieve this, we will use advanced data science methodologies and Bayesian statistical techniques to develop a data architecture that curates and combines from four sources: Fixed patient-level factors (HLA-DP phenotype, granular clinical dataset obtained at diagnosis), External medical influences (maintenance immunosuppression, antibiotic prescriptions, Hospital Inpatient Enquiry records), External environmental influences, linked to patient location through time (meteorological data streams, community pathogen patterns: readily available as online data streams) and Direct patient-derived data sources (location, patient-reported quality of life and accelerometer defined activity). We expect a 50% rate of relapse after 5 years in a cohort of patients derived from the Rare Kidney Disease registry; we shall describe for the first time the relapse prodrome and define in great detail the environmental influences linking to this event.
  • Funding Agency
    • HRB
  • Date From
    • 1/2/17
  • Date To
    • 1/2/20
  • Title
    • Urinary sCD163 as a biomarker in crescentic glomerulonephritis
  • Summary
    • This project is focused on development of a novel biomarker test in the diagnosis and monitoring of crescentic glomerulonephritis (CGN), a severe form of inflammatory kidney injury. This test relies upon identification of a single protein in the urine: soluble CD163. This is shed from activated macrophages, the predominant cell in glomerular crescents, which are in direct communication with the urinary space. Extensive experimental work in our laboratory has brought this biomarker to technology readiness level 3. This project will bring it to level 7, laying the foundation for a definitive trial.
  • Funding Agency
    • HRB
  • Date From
    • 1/1/19
  • Date To
    • 1/2/20
  • Title
    • Irish Rare Kidney Disease Registry and Biobank
  • Summary
    • We aim to recruit, register and biobank all incident patients with systemic vasculitis in Ireland. Much effort is put into ensuring the first sample set is obtained before any treatment is given. Subsequent longitudinal sample sets are obtained over the next 5 years. This is being run in collaboration with the Tallaght Vasculitis and Allergy Group
  • Funding Agency
    • Meath Foundation
  • Date From
    • Sep 2012
  • Title
    • The acute, untreated patient with vasculitis: enhancing recruitment and sampling using a national network
  • Summary
    • The Tallaght Vasculitis and Allergy Group (TVA Group) aims to provide joined up, efficient and excellent care to patients with systemic vasculitic and allergic conditions by developing a strong multi-disciplinary alliance within Tallaght Hospital. By combining the academic strength of the members, the group also aims to maximise research funding credibility and to provide a mechanism for national and international research network engagement. The RKD biobank and registry is an established infrastructure which feeds into the academic arm of the TVA Group. It is co-chaired by Mark Little and Peter Lavin on behalf of the group. Its goal is to capture long-term longitudinal clinical data and high quality biological samples from patients with systemic vasculitic and allergic disorders, disease controls and healthy controls. Coordinated from Tallaght Hospital, it currently receives data and samples from five centres across Ireland and has been actively recruiting since September 2012. In this relatively short period of time it has become one of the most important bio-resources in this field globally. To maximise its potential we now wish to target a specific patient group for recruitment: those with very active disease who have not yet been treated with immune suppressing medication. These are very challenging to recruit as they can present at any time of day or night and need to be sampled very rapidly (usually less than one hour) - hence these type of patients are virtually absent from existing biobanks around the world, despite being the most valuable in studying the disease. By extending recruitment to the whole country using the current grant proposal, we believe we can recruit an additional 70 such patients, making the biobank unrivalled anywhere, and an invaluable resource for discovering new biomarkers and studying disease mechanisms in these rare diseases.
  • Funding Agency
    • Meath Foundation
  • Date From
    • 01/09/2014
  • Date To
    • 31/08/2017
  • Title
    • Interplay between Interferon-alpha and low density granulocytes in ANCA vasculitis: a key pathogenic pathway underpinned by NETosis?
  • Summary
    • Anti-neutrophil cytoplasm autoantibody (ANCA) vasculitis (AAV) is a severe, systemic autoimmune disease, and one of the leading causes of progressive glomerulonephritis,which often results in kidney failure. It is a neutrophil driven disease, with antibodies targeting the neutrophil granule proteins myeloperoxidase (MPO) and proteinase 3(PR3. Binding of ANCA to these antigens leads to inappropriate neutrophil activation,and subsequent damage to endothelial cells, with consequent chronic, unresolving vascular inflammation. The reason for the loss of control over this neutrophil-initiated inflammation is unknown; 1. There is strong recent evidence that the ANCA-induced release of neutrophil extracellular traps (NETs) plays an important role in AAV pathogenesis. NETs are composed of nuclear chromatin, histones and antimicrobial proteins and are released in process called NETosis, a specialised form of neutrophil death. 2. Interferon á (IFNá) is upregulated in AAV patient serum and is strongly associated with an increased risk of glomerulonephritis. Interestingly, IFNá can prime neutrophils to undergo NETosis in response to C5a, a proinflammatory complement protein fragment shown to be important in ANCA-associated glomerulonephritis, and it is likely that IFNá also enhances ANCA-induced NETosis. 3. A number of studies have identified a subpopulation of low-density granulocytes (LDGs), with all the characteristics of neutrophils, that co-purify with peripheral blood mononuclear cells (PBMCs). Compared to normal density neutrophils (NDGs), these show a markedly enhanced propensity to NETosis, and to release IFNá. Our preliminary data show that LDGs are present in relatively high numbers in patients with AAV. Thus, we hypothesise that LDGs in AAV are capable of inducing tissue damage via IFNá production, which primes both NDGs and LDGs to undergo NETosis.
  • Funding Agency
    • Irish Research Council
  • Date From
    • 01/10/2014
  • Date To
    • 01/03/2017
  • Title
    • Probing the metabolic response to vasculitic injury: towards a tool for non-invasive monitoring of immune activation in ANCA vasculitis
  • Summary
    • The objective of the proposed work is to identify a non-invasive marker of immune activation in AAV. I will incorporate pre-clinical and clinical tools to study the urinary metabolomic signature at various stages of active, inactive and tolerant AAV. This project will require biobank development including patient recruitment and sample processing. We will then develop an in vivo model of anti-myeloperoxidase (anti-MPO) AAV. The urinary metabolomic signature of the in vivo model and patient samples will be interrogated using mass spectroscopy. Bioinformatics expertise and statistical modelling will then be undertaken to identify a sensitive and specific urinary metabolomic signature of immune activation in AAV. I will then collaborate with University College London Centre for Nephrology and the Immune Tolerance Network and interrogate the urinary metabolomic signature in tolerant patients. These results will then be validated by development of an in vivo model of tolerant AAV. Metabolomics is the non-targeted measurement of all metabolites produced by the body, it is a promising area in biomarker development. It has been used to identify biomarkers in other kidney diseases including acute kidney injury and polycystic kidney disease.
  • Funding Agency
    • Health Research Board
  • Date From
    • 01/10/2013
  • Date To
    • 30/06/2018
  • Title
    • Determining the breadth and burden of Chronic Kidney Disease in Ireland: Associations with cognitive impairment, functional decline and quality of life
  • Summary
    • Chronic kidney disease (CKD) is a major health problem all over the world. At least 1 in 10 adults are estimated to have kidney disease. Some of these people will progress to end-stage kidney disease which requires dialysis treatment or a kidney transplant for survival. However the majority of people with CKD do not survive long enough to reach end-stage kidney disease because of high rates of early-onset heart disease and premature death. What is driving these poor outcomes in people with CKD is not fully understood. The extent to which kidney disease affects Irish people is unknown. There is an urgent need for precise information about the impact of CKD in Ireland, so that healthcare resources can be directed at those that need them most. The Irish Longitudinal Study on Ageing (TILDA) has gathered detailed health information on a representative sample of over 8000 members of the Irish general population aged 50 years and over. As CKD is predominantly a disease of older age, TILDA is the perfect setting in which to study this disease. The goals of the proposed research are three-fold: to determine the rates of all stages of CKD in the Irish general population; to explore the impact of CKD on the physical and cognitive health of Irish older adults; and to identify those people with CKD most at risk for complications, whom we expect would benefit most from medical intervention. This important research will provide critical information to policy makers towards developing and implementing a national strategy designed to improve the health of Irish people with kidney disease.
  • Funding Agency
    • Health Research Board
  • Date From
    • 15/09/2014
  • Date To
    • 14/09/2017





Autoimmune strand lead, RITA European Reference Network 1/3/17

Co-chair UKIVAS national vasculitis registry 2010

Co-chair UKIVAS, the vasculitis rare disease group of the UK and Ireland 2011

Registries lead, European Vasculitis Society 2014

Chair Irish Rare Kidney Disease Registry and Biobank 2012

Chair of Irish Nephrology Society research committee 2015

Awards and Honours

President of Ireland Young Researchers Award 2012


Fellow of Trinity College Dublin 1/5/13

Fellow of the Royal College of Physicians 2012

American Society of Nephrology 2010

The Renal Association 2008