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Dr. David Coghlan
MEDICAL SCHOOL, Paediatrics
Clinical Senior Lecturer, School Office - Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

C Howard, WL Macken, A Connolly, M Keegan, D Coghlan, DW Webb, Percutaneous endoscopic gastrostomy for refractory epilepsy and medication refusal, Arch Dis Child, 2019 Journal Article, 2019 DOI

Rutledge E, Whitla L, Coghlan D, Nadeem M, Peripheral White Blood Cell Differential Counts In Children With UTI, Is There A Link?, Ir Med J , 111, (6), 2018 Journal Article, 2018

Hutchinson K, Kerley CP, Faul J, Greally P, Coghlan D, Louw M, Elnazir B, Rochev Y. , Vitamin D receptor variants and uncontrolled asthma , Eur Ann Allergy Clin Immunol. 2018 , 2018 Journal Article, 2018 DOI

Kerley CP, Elnazir B, Greally P, Coghlan D. , Blunted serum 25(OH)D response to vitamin D3 supplementation in children with autism, Nutr Neurosci. , 2018 Journal Article, 2018 DOI

Khan N, Whitla L, Kenosi M, Coghlan D, Nadeem M. , Follow up chest radiography in paediatric pneumonia: is it avoidable? , Ir Med J, 2018 Journal Article, 2018

N Gadelsayed, D Coghlan, Influenza in children; is there a pattern of adverse outcomes and are inflammatory markers predictive?, Joint Irish Paediatric Association/Welsh Paediatric Society Meeting 2018, 2018 Meeting Abstract, 2018

N Gadelsayed, D Coghlan, Case series of herpes simplex virus meningoencephalitis in a single paediatric centre over a 10-year period , Joint IPA/Welsh Paediatric Society , 2018, 2018 Meeting Abstract, 2018

Kerley CP, Power C, Gallagher L, Coghlan D , Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT, Arch Dis Child 2017 , 2017 Journal Article, 2017 DOI

Kenosi M, Whitla L, Khan N, Carty E, Coghlan D, Nadeem M, Interpretation of pyuria in children with urinary tract infection , Acta paediatrica (Oslo, Norway : 1992) , 2017 Journal Article, 2017 DOI URL

Macken WL, Clarke N, Nadeem M, Coghlan D, Life After the Event: A Review of Basic Life Support Training for Parents Following Apparent Life-Threatening Events and Their Experience and Practices Following Discharge , Ir Med J, 110 , (5 ), 2017, p572 - 574 Journal Article, 2017 URL

S Neville, N Gadelsayed, D Coghlan, Working to implement guidelines for UTI assessment and management: the "Wiguam" quality improvement initiative , Irish Paediatric Association , 2017, 2017 Meeting Abstract, 2017

M Alsaffar, N Gadelsayed, D Coghlan, Molloy E, Prevalence of Coeliac Disease in Children with Down syndrome, Archives of Disease in Childhood 2017;102:A106., Pediatric Academic Societies (PAS) 2017 Meeting, May 6 - 9, in San Francisco, CA.Meeting Abstract, San Francisco, 2017, 102, 2017 Meeting Abstract, 2017

N Khan, D Coghlan, N Gadelsayed, Follow Up Chest Radiography in Paediatric Pneumonia: Is It Avoidable? , IPA, 2017 Meeting Abstract, 2017

E Carty, D Coghlan, N Gadelsayed, Interpretation of pyuria in children with urinary tract infection, IPA, 2017 Meeting Abstract, 2017

Reynolds A, O'Driscoll J, Quinn S, Coghlan D. , Cows Milk Allergy: A Cohort of Patients from a University Hospital, Ir Med J. , 2016 Journal Article, 2016

S Tamgumus, J Geoghegan, D Coghlan, M Nadeem. , Urinary tract infection in childhood and inflammatory markers , IPA, 2016 Meeting Abstract, 2016

Tamgumus S, Geoghan J, Coghlan D, Nadeem M, Urinary Tract Infection in Childhood and Inflammatory Markers, Ir Med J, 109 , (7 ), 2016, p442 - Journal Article, 2016 URL

Kerley CP, Hutchinson K, Cormican L, Faul J, Greally P, Coghlan D, Elnazir B, Vitamin D3 for uncontrolled childhood asthma: a pilot study, Pediatric Allergy and Immunology 27 (4), 404-412 , 2016 Journal Article, 2016 DOI

WL Macken, D Coghlan, N Montasseur, An audit of basic life support training for parents following apparent life threatening events (ALTE) in early childhood., IPA, 2015, 2015 Meeting Abstract, 2015

CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , A randomized, double-blind, placebo-controlled of Vitamin D3 for Irish children with asthma , Nutrition Society, 2015 Meeting Abstract, 2015

Murphy K, Scanlan B, Coghlan D, Does this child really have a penicillin allergy?, Ir Med J, 2015 Journal Article, 2015

CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , The Effects of Vitamin D Supplementation on Pulmonary Function, Disease Severity and Markers of Inflammation in Childhood Asthmatics: A Randomized, Double-Blind, Placebo , IPA, 2014 Meeting Abstract, 2014

Cunningham K, Scanlan B, Coghlan D, Quinn S, Infants with FPIES to solid food proteins--chicken, rice and oats, Ir Med J., 2014 Journal Article, 2014

CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir (ed.), Proceedings of the Nutrition Society 73 (OCE2), 2014, 2014 Proceedings of a Conference, 2014

Scanlan B, Nadeem M, Ryan M, Smith O, O'Marcaigh A, Coghlan D, Acute leukaemia presenting with isolated bone pain, Arch Dis Child, 98 , (10), 2013, 771- Journal Article, 2013 DOI

Nadeem M, Oni OA, Ryan M, Puri P, Coghlan D, Greally P, Girl with xanthogranulomatous pyelonephritis and bronchiectasis: case report., Pediatrics International, 2013 Journal Article, 2013 DOI

CW Teoh, M Mavinkurve, U Damachi, S Medani, M Waldron, D Coghlan , Vesico-ureteric reflux and renal scarring in children under 1 year of age with first urinary tract infection , PEDIATRIC NEPHROLOGY , 2011 Journal Article, 2011

J O'Brien, EB Williams, D Coghlan, Is ultrasound a useful tool in the diagnosis of failure to thrive? Preliminary findings from the faltering growth (FIG) study , Irish journal of medical science 179, S204-S204, 2010 Journal Article, 2010

M Curtin, D Coghlan , Missed vaccines, missed opportunity , Irish Journal of Medical Science , 2010 Journal Article, 2010

M Omer, EB Williams, D Coghlan, How useful is the measurement of crp, total white cell and neutrophil counts in differentiating between bacterial and other causes of fever in children? , Irish Journal of Medical Science , 2010 Journal Article, 2010

M White, E Williams, M Curtin, D Coghlan , Smaller size and its developmental associations , Acta Paediatrica, 2009 Journal Article, 2009

Deasy C, O'Mahony O, Coghlan D, Fitzgerald E, Isoparaffin poisoning in an 18-month-old girl., Ir Med J, 2007 Journal Article, 2007

McManus V, Coghlan D, Are hospital based notifications enough? Achieving accurate case ascertainment--the Southern Ireland Cerebral Palsy Register (SICPR), Ir Med J, 2005 Journal Article, 2005

Cerebral Palsy Registries in, Seminars in Pediatric Neurology , Seminars in Pediatric Neurology 1, 2004, pp18 - 23, [C Cans, G Surman, V McManus, D Coghlan, O Hensey, A Johnson ] Book Chapter, 2004

Cans C, Surman G, McManus V, Coghlan D, Hensey O, Johnson A, Cerebral palsy registries., 2004 Journal Article, 2004

Coghlan D, Powell C, Treatment of childhood asthma: how do the available options compare?, Pediatric Drugs 5 (10), 685-698 , 2003 Journal Article, 2003

Coghlan D, Kiing JS, Wake M, Parents' Evaluation of Developmental Status in the Australian day-care setting: developmental concerns of parents and carers., Journal of Paediatrics and Child Health 39 (1), 49-54, 2003 Journal Article, 2003

Coghlan D, Lynch B, Allcutt D, Hereditary cerebral cavernous angiomas: presentation as idiopathic familial epilepsy, Ir Med J, 2002 Journal Article, 2002

Coghlan D, Cranswick NE, Complementary medicine and vitamin A toxicity in children, Medical Journal of Australia , 2001 Journal Article, 2001

Wake M, Coghlan D, Hesketh K, Does height influence progression through primary school grades?, Arch Dis Child, 2000 Journal Article, 2000

Cranswick N, Coghlan D, Paracetamol efficacy and safety in children: the first 40 years., American Journal of Therapeutics, 2000 Journal Article, 2000

Coghlan D, Milner M, Clarke T, Lambert I, McDermott C, McNally M, Beckett M, Matthews T, Neonatal abstinence syndrome, Ir Med J, 1999 Journal Article, 1999

Non-Peer-Reviewed Publications

J Dinsmore, E Williams, H McCarthy, D Coghlan Journal of Human Nutrition and Dietetics 24 (3), 280-281, A pilot study to explore factors affecting faltering growth in children , Journal of Human Nutrition and Dietetics 24 (3), 280-281, 2011 Journal Article, 2011

Research Expertise

Description

General Paediatrics is an acute specialty caring for the undifferentiated child. It is an emerging academic specialty with a focus on clinical research and quality improvement. Since my time as a fellow at RCH Melbourne I concentrated on early child development and how clinicians and parents must collaborate to define a child's abilities in the home, school and play settings. This work included those with developmental delay and those with more severe disabilities such as cerebral palsy. More recent work has focused on interventions including Vitamin D supplementation to improve symptoms in children with Autism and Asthma. While adequate nutrition is essential many child still require daily medication and my work has also looked at improving methods of medication administration in those with acute infection, allergy and complex needs. A novel method of delivering anti-epileptic method through a feeding tube was described with great benefits for children with complex needs. Randomised Controlled trials: 1. RCT of Vitamin D supplementation in autism spectrum disorder. Randomised 42 children to receive 2000 IU Vitamin D3 daily or placebo over 20 weeks. Vitamin D had no effect on primary outcome of reducing stereotypic autistic behaviours. Trend towards reduced inappropriate speech in the Vitamin D3 treatment group. 2. RCT of Vitamin D supplementation in uncontrolled asthma. Randomised 44 children with uncontrolled asthma to receive 2000 IU Vitamin D3 or placebo over 15 weeks. Vitamin D had no effect on primary outcome of improved subjective asthma control or Fev1 on spirometry. There was a non-significant improvement in Fev1 within the placebo group. Finally we've explored variation in medication response by examining genetic variants in asthma. An association was found between Taql (exon 9) and Apal (intron 8) polymorphisms and asthma risk. IL10 levels were lower in asthmatic children with Taql polymorphisms. I've also developed national guidelines published as the WIGUAM Study (Working to Implement National Guidelines for Urine Tract Infection Assessment and Management ).

Projects

  • Title
    • Protocol for Investigation of Penicillin Allergy.
  • Summary
    • Feasibility Study to Implement National Protocol for Investigation of Penicillin Allergy in children
  • Funding Agency
    • The National Children's Hospital Foundation
  • Date From
    • April 2012
  • Date To
    • April 2013
  • Title
    • An RCT of Vitamin D3 in Uncontrolled Asthma
  • Summary
    • A double-blind, randomized, PL-controlled trial of vitamin D supplementation (2000 IU/day) in 44 urban, caucasian children at high latitude. Conclusion: Vitamin D3 supplementation led to a significant increase in serum 25(OH)D and decreased school days missed (p = 0.04), but no other advantageous changes in asthma parameters compared with PL.The potential negative effect of high serum 25(OH)D on pulmonary function warrant further investigation.
  • Funding Agency
    • National Children's Hospital Foundation
  • Date From
    • January 2014
  • Date To
    • January 2015
  • Title
    • An RCT of Vitamin D3 in Paediatric Autism
  • Summary
    • A double-blind, randomised, placebo-controlled trial set in a paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). Conclusion: Vitamin D supplementation had no effect on the primary outcome with limited and inconsistent effects in children with ASD. Considering the other promising data as well as the relative safety and cheapness of vitamin D supplementation, further trials are warranted.
  • Funding Agency
    • The National Children's Hospital Foundation
  • Date From
    • Jan 2015
  • Date To
    • Jan 2016
  • Title
    • PROSPER: PaediatRic Outcomes and Serum biomarker Panel in acutE traumatic bRain injury /concussion to severe traumatic 2015-9.
  • Summary
    • To describe the demographics and aetiology of traumatic brain injury presenting to Irish Paediatric Emergency Departments. Concussion and mild traumatic brain injury (mTBI) are interchangeable terms.Post-concussion syndrome (PCS) occurs in 1/7 children sustaining a mTBI.Secondly to describe physician competence in this condition and to develop a best practice guideline. To elucidate biomarkers from the innate immune system that are activated in acute brain injury. Findings include preschool children have the highest incidence of head injury, mostly following a fall. There was a paucity of knowledge among all grades of medical professionals in how to manage these children. Many patients had a raised white cell count with neutrophilia. Surprisingly CD 11b neutrophil expression was not raised in mTBI on flow cytometry, but was markedly raised in the 4 most severe TBI patients.
  • Funding Agency
    • National Children's Hospital Foundation
  • Date From
    • 2016
  • Date To
    • 2019
  • Title
    • PRISM: PReterm Infection and SysteMic inflammation and neonatal outcomes.
  • Summary
    • This research aims to improve the understanding of the systemic inflammatory response in preterm infants and the potential for newer adjunctive therapies. In addition trying to identify immune markers that will assist in the prognosis and clinical outcomes of these preterm infants.
  • Funding Agency
    • The National Children's Hospital Foundation and Trinity College Dublin
  • Date From
    • 2016
  • Date To
    • 2019
  • Title
    • Bright Horizons Study
  • Summary
    • Bright Horizons Study. Neurodevelopmental follow up of preterm infants including psychological profiling at age 24 months corrected. Also to investigate the developmental outcomes of children with a history of HIE (Hypoxic Ischemic Encephalopathy).
  • Funding Agency
    • NCH Foundation
  • Date From
    • 2015
  • Date To
    • 2017
  • Title
    • FIG Study
  • Summary
    • Faltering growth In General paediatrics Clinic (FIG) was a 1 year study exploring the determinants of poor growth in toddlers. The effect of maternal and social factors on faltering growth (FG) are unclear from published research. A control comparison of 24 children recruited through clinics in AMNCH was undertaken (12 FG, 12 controls). Participating parents completed a health, social,and demographic questionnaire and a 7 day food diary was completed using household measures. Diaries were analysed using NETWISP for protein , fat, carbohydrate, and vitamin content. All data were entered in SPSS. There were no significant difference between FG and control groups in maternal health or social factors. There were no differences in the feeding histories between the two groups. However the mean intake of all nutrients except protein, monounsaturated fat, starch, sodium and B12 were all higher in the control group. These findings support hypothesis that poor nutritional intake is main cause of faltering growth in this group. There was a trend towards lower breast feeding rates in the FG group.
  • Funding Agency
    • NCH Foundation
  • Date From
    • 2009
  • Date To
    • 2010

Keywords

ACUTE CHILDHOOD ASTHMA; Allergy; Cerebral Palsy; CHILDHOOD ASTHMA; VITAMIN-D SUPPLEMENTATION

Recognition

Representations

HSE-Acute Floor Implementation Process Group( Paediatric Representative) 2018

National Electronic Health Record (EHR) Programme. Paediatric EHR Working Group 2018

Paediatric Clinical Advisor, Coeliac Society of Ireland 2018

Chair, National Guideline Committee -Management of Urinary Tract Infection in children 2015

Paediatric expert reviewer for Irish Medical Council 2016

Expert external case reviewer supporting Director Of Quality, CHI (Children's Hospital Ireland) 2018

Reviewer for Irish Medical Journal 2015

Awards and Honours

Irish Paediatric Association (IPA)- Best Oral Presentation WIGUAM Study 2017

IPA-Best Poster "FPIES in infancy" 2015

Paediatrician of the Year-Laya Healthcare Awards 2015

Memberships

FRCPI-Fellow of the Royal College of Physicians, Ireland 2002 – 2019

FRCPCH (UK)-Fellow of the Royal College of Physicians and Child Health 2003 – 2019

GAPRUKI Collaboration-General and Adolescent Paediatrics UK and Ireland Member(Research Collaboration Body) -Founding member 2016 – 2019

Faculty of Paediatrics, RCPI 2006 – 2019

ERS-European Respiratory Society Member 2003 – 2019

EAACI, European Academy of Allergy and Immunology, Member 2007 – 2019

MPS-Medical Protection Society Member 1993 – 2019

Irish Paediatric Surveillance Unit (IPSU) 2003 – 2019

British Paediatric Surveillance Unit (BPSU) 2003 – 2019