Dr. Maria Santos-Martinez

• Tomaszewski KA, Radomski MW, Santos-Martinez MJ. , Nanodiagnostics, Nanopharmacology and Nanotoxicology of Platelet - Vessel Wall Interactions., Nanomedicine (Lond.), 10, (9), 2015, p1451 - 1475Review Article, 2015, DOI
• Gaffney, A.M., Santos-Martinez, M.J., Satti, A., (...), Elia, G., Radomski, M.W. , Blood biocompatibility of surface-bound multi-walled carbon nanotubes, Nanomedicine: Nanotechnology, Biology, and Medicine, 11, (1), 2015, p39-46Journal Article, 2015, DOI
• Niska, K., Santos-Martinez, M.J., Radomski, M.W., Inkielewicz-Stepniak, I. , CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin, Toxicology in vitro, 29, 2015, p663 - 671Journal Article, 2015, DOI
• Larkin, C.M., Santos-Martinez, M.-J., Ryan, T., Radomski, M.W., Sepsis-associated thrombocytopenia, Thrombosis Research, 141, 2016, p11-16Review Article, 2016, DOI
• Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Jurasz P, Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation., Cardiovascular research, 113, (14), 2017, p1719 - 1731Journal Article, 2017, DOI
• Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology., Platelets, 29, (3), 2018, p301 - 304Journal Article, 2018, DOI
• Nam, L.; Coll, C.; Erthal, L.C.S.; de la Torre, C.; Serrano, D.; Martínez-Máñez, R.; Santos-Martínez, M.J.; Ruiz-Hernández, E., Drug delivery nanosystems for the localized treatment of glioblastoma multiforme, Materials, 11, (5), 2018, p779-Review Article, 2018, DOI
• Santos-Martínez MJ, Curull V, Blanco ML, Macià F, Mojal S, Vila J, Broquetas JM, [Lung cancer at a university hospital: epidemiological and histological characteristics of a recent and a historical series], Archivos de bronconeumologia, 2005Journal Article, 2005
• Jericó Alba C, Nogués Solán X, Santos Martínez MJ, Félez Flor M, Garcés Jarque JM, Mariñosa Marré M, Sanz Salvador X, [Legionella pneumophila pneumonia community epidemic outbreak in Barcelona: "The Barceloneta outbreak". Effect on the early diagnosis and treatment], Revista clinica espanola, 2004Journal Article, 2004
• María Molina-Molina, Joan Ramon Badia, Alejandra Marín-Arguedas, Antoni Xaubet, María José Santos, José María Nicolás, Miguel Ferrer, Antoni Torres, Características clínicas y pronóstico de los pacientes con fibrosis pulmonar que ingresan en cuidados intensivos por insuficiencia respiratoria. Análisis de 20 casos, Medicina Clínica, 121, (2), 2003, p63--67Journal Article, 2003
• Larkin CM, Hante NK, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia., PloS one, 2018Journal Article, 2018, DOI
• Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, 1. Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection, International Journal of Pharmaceutics, 552, (1-2), 2018, p27 - 38Journal Article, 2018, DOI
• Chan Guo Gin C; Lam C; Hante N; Keogh AP; Kelly B, Rozas I; Santos-Martinez MJ. , Effect of novel H2-receptor selective compounds on platelet aggregation, Pharmacology 2018, London, 18-20 December 2018, 2018Meeting Abstract, 2018
• Pharmacology of Haemostasis and Thrombosis in, Velazquez Farmacologia Basica y Clinica (19th Edition) , Ed. Medica Panamericana, 2018, [Santos-Martinez MJ; Radomski MW; Medina C.]Book Chapter, 2018
• Santos-Martinez MJ, A novel method for the measurement of flow-induced platelet activation at nanoscale resolution Level., TCD, 2009Thesis, 2009
• Mugheirbi N, Zotova J, Umerska AM, Santos-Martinez MJ, Tajber L. , Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017Meeting Abstract, 2017
• D'Arcy DM; Connell Y; Santos-Martinez MJ, 6. Clinically relevant dissolution testing: exploring albumin concentrations in testing of parenteral formulations, 10th Central European Symposium on Pharmaceutical Technology (CESPT) Conference, Portoro , Slovenija, 2014Meeting Abstract, 2014
• Mugheirbi N; Zotova J; Umerska AM; Santos-Martinez MJ; Tajber L, Novel surfactant-stabilized ciprofloxacin nanodispersions made by media milling; interactions with physiological barriers using quartz crystal microbalance with dissipation monitoring, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017Meeting Abstract, 2017
• Cruz R; Bowe R; Santos-Martinez MJ; Tajber L, 3. Investigation of interactions of pegylated and non-pegylated itraconazole nanoparticles with mucin using quartz crystal microbalance with dissipation and dynamic light scattering, AAPS Annual Meeting and Exposition, San Diego, USA, 12-15 November, 2017Meeting Abstract, 2017
• Keogh AP; Hante N; Santos-Martinez MJ; Kelly B; Rozas I. , 4. Exploring the polypharmacology of 2-amino imidazoline derivatives: Antiaggregatory activity in human platelets, Medicinal Chemistry Ireland Conference 2018, Dublin City University, Dublin, Ireland, June , 2018Meeting Abstract, 2018
• Svenja Sladek, Fiona McCartney, Mena Eskander, David J. Dunne, Maria Jose Santos-Martinez, Federico Benetti, Lidia Tajber, David J. Brayden, An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer, Pharmaceutics, 12, (3), 2020, p259Journal Article, 2020
• Justyna Hajtuch, Nadhim Hante, Ewelina Tomczyk, Michal Wojcik, Marek Witold Radomski, Maria Jose Santos-Martinez, Iwona Inkielewicz-Stepniak,

  Effects of functionalized silver nanoparticles on aggregation of human blood platelets

  , International Journal of Nanomedicine, Volume 14, 2019, p7399--7417Journal Article, 2019
• Smeaton T; McElwaine P; Cullen J; Santos-Martinez MJ; Deasy E; Widdowson M; Grimes T., A prospective observational pilot study of adverse drug reactions contributing to hospitalization in a cohort of middle-aged adults aged 45-64 years., Drugs & Therapy Perspectives , 36, 2020, p123 - 130Journal Article, 2020
• Vasconcelos JM, Zen F, Angione MD, Cullen RJ, Santos-Martinez MJ, Colavita PE. , Understanding the Carbon-Bio Interface: Influence of Surface Chemistry and Buffer Composition on the Adsorption of Phospholipid Liposomes at Carbon Surfaces., ACS Applied Bio Materials., 3, (2), 2020, p997 - 1007Journal Article, 2020, DOI , URL , TARA - Full Text
• Vasconcelos JM, Zen F, Angione MD, Cullen RJ, Santos-Martinez MJ, Colavita PE. , Understanding the Carbon-Bio Interface: Influence of Surface Chemistry and Buffer Composition on the Adsorption of Phospholipid Liposomes at Carbon Surfaces., ACS Applied Bio Materials., 3, (2), 2020, p997 - 1007Journal Article, 2020, DOI , URL , TARA - Full Text
• Paweł Melchior Pasieka; Krzysztof Marycz; Marek Radomski; Maria Jose Santos-Martinez; Przemysław Andrzej Pękala; Iwona Tomaszewska; Krzysztof Andrzej Tomaszewski., Cobalt Nanoparticles Cause Major Platelet Aggregation In Vitro While Chromium Nanoparticles Induce Platelet Lysis In Vitro., The FASEB Journal, Experimental Biology (EB) 2020 meeting, , San Diego, 4th-7th April 2020, 34, (S1), 2020Poster, 2020, URL
• Jakub Radosław Pêkala, Przemysław Andrzej Pêkala, Iwona Maria Tomaszewska, Maria Jose Santos-Martinez, Marek Radomski, Mateusz Paweł Paziewski, Paweł Melchior Pasieka, Krzysztof Andrzej Tomaszewski., Aluminium Nanoparticles Released by Joint Implants‐Quartz Crystal Microbalance with Dissipation Analysis., The FASEB Journal, Experimental Biology (EB) 2020 meeting, , San Diego, 4th-7th April 2020, 34, (S1), 2020Poster, 2020, URL
• Amelia Ultimo, Mar Orzaez, Maria J Santos-Martinez, Ramón Martínez-Máñez, María D Marcos, Félix Sancenón, Eduardo Ruiz-Hernández, High-capacity mesoporous silica nanocarriers of siRNA for applications in retinal delivery, International Journal of Molecular Sciences, 24, (3), 2023, p2753-Journal Article, 2023, URL
• Hajtuch J, Iwicka E, Szczoczarz A, Flis D, Megiel E, Cieciórski P, Radomski MW, Santos-Martinez MJ, Inkielewicz-Stepniak I, 3. The pharmacological effects of silver nanoparticles functionalized with eptifibatide on platelets and endothelial cells., International Journal of Nanomedicine, 17, 2022, p4383-Journal Article, 2022
• Menzel V, Ziegler M, Hante NK, Sake JA, Santos-Martinez MJ, Ehrhardt C, Kasper M, Barth K. , 4. Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis, European Journal of Pharmaceutical Sciences, 175, 2022, p106-Journal Article, 2022
• Hajtuch J, Santos-Martinez MJ, Wojcik M, Tomczyk E, Jaskiewicz M, Kamysz W, Narajczyk M, Inkielewicz-Stepniak I. , 5. Lipoic Acid-Coated Silver Nanoparticles: Biosafety Potential on the Vascular Microenvironment and Antibacterial Properties. , Frontiers Pharmacology, 2022, p733-Journal Article, 2022
• Amet R, Previtali V, Mihigo HB, Sheridan E, Brophy S, Hante NK, Santos-Martinez MJ, Hayden PJ, Browne PV, Rozas I, McElligott AM, Zisterer DM. , 6. A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma. , Life Sciences., 2022Journal Article, 2022
• Ricardo Machado Cruz, Tereza Boleslavská, Josef Beránek, Eszter Tieger, Brendan Twamley, Maria Jose Santos-Martinez, Ond"ej Dammer, Lidia Tajber, Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal, Pharmaceutics, 12, (8), 2020, p741Journal Article, 2020
• Kulkarni A, Bazou D, Santos-Martinez MJ., The role of Platelets in Multiple Myeloma, EACR-AACR Basic and Translational Research Conference: How to Bring Basic Science Discoveries to the Clinic, Dublin, 27-29/2/2024, 2024Poster, 2024
• Jurasz, P., Santos-Martinez, M.J., A. Radomska, Radomski, M.W. , Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects of angiogenesis, Journal of Thrombosis and Haemostasis, 4, (5), 2006, p1095 - 1106Journal Article, 2006, DOI , URL
• Jurasz, P., Santos-Martinez, M.J., Radomska, A., Radomski, M.W. , Development and pharmacological characterization of a novel, plasma-based angiogenesis assay, Kardiochirurgia i Torakochirurgia Polska, 4, (2), 2007, p126 - 130Journal Article, 2007, URL
• Santos-Martinez, M.J., Medina, C., Gilmer, J.F., Radomski, M.W. , Matrix metalloproteinases in platelet function: coming of age. , Thrombosis and Haemostasis, 6, (3), 2008, p514-516Review, 2008, DOI , URL
• Rosell A, Xaubet A, Agusti C, Castella J, Puzo C, Curull V, de Gracia J; RASTA study group., A NEW BAL FLUID INSTILLATION AND ASPIRATION TECHNIQUE: A MULTICENTER RANDOMIZED STUDY. , Respir Med. Mar;100(3):529-535., 2006Journal Article, 2006, DOI
• Santos-Martinez MJ, Medina C, Booth J, Radomski W. , A novel method for the measurement of platelet aggregation under flow conditions using Nanobalance, All-Ireland Schools of Pharmacy Research Seminar , Royal College of Surgeons, 2007 , 2007Oral Presentation, 2007
• Santos-Martinez, M.J., Inkielewicz-Stepniak, I., Medina, C., Rahme, K., D'Arcy, D., Holmes J.D., Zhang, H., Radomski, M.W, The use of quartz crystal microbalance with dissipation for studying nanoparticle-induced platelet aggregation. , International Journal of Nanomedicine, 7, 2012, p243 - 255Journal Article, 2012, DOI
• Lesniak, A., Salvati, A., Santos-Martinez, M.J., Radomski, M.W., Dawson, K.A., Aberg, C. , Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency, Journal of American Chemical Society, 135, 2013, p1438 - 1444Journal Article, 2013, DOI
• Inkielewicz-Stepniak, I., Santos-Martinez, M.J., Medina, C., Radomski, M.W. , Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride, International Journal of Nanomedicine, 9, 2014, p1677 - 1687Journal Article, 2014, TARA - Full Text
• Gaffney, A.M., Santos-Martinez, M.J., Satti, A., Major, T.C., Wynne, K.J., Gun'ko, Y.K., Annich, G.M., Elia, G., Radomski, M.W, Blood biocompatibility of surface-bound multiwall carbon nanotubes. , Nanomedicine: NBM Feature Article, 11, 2015, p39 - 46Journal Article, 2015, DOI

• Gilmer JGF, Ryan F, Seoighe A, Santos-Martinez MJ, Ryan C, Ledwidge M., 7. Iron deficiency in Women of Childbearing Age with Self-reported Oral Iron Gastrointestinal Intolerance and Management with an oral Iron-Whey-Protein Formulation. , medRxiv, 2021Report
• Kulkarni A, Bazou D, Santos-Martinez MJ., Bleeding and Thrombosis in Multiple Myeloma: Platelets as Key Players during Cell Interactions and Potential Use as Drug Delivery Systems, International Journal of Molecular Sciences, 24, (21), 2023, p15855-Journal Article
• Anushka Kulkarni , Maria Jose Santos-Martinez , Despina Bazou, The role of platelets in multiple myeloma, Irish Association of Pharmacologists Annual Meeting, Cork, 3/11/2023, 2023Oral Presentation
• Maria J Santos-Martinez, 7th Pulmonary Drug Delivery Workshop, Dublin, 21/04/2022, 2022Invited Talk

Dr Santos-Martinez research interests are focused on blood platelets biology and pharmacology; nanoparticle-cell and nanoparticle-blood platelets interactions (Nanotoxicology/Biocompatibility of nanomaterials) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and extremely sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating 1) the effect of different compounds, nanomaterials and novel formulations on platelet function and 2) the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).

Nanotechnology, Biochemistry and cell biology, Cardiovascular medicine and haematology, Cancer, Pharmacology and pharmaceutical sciences, Clinical Medicine,

• Fellow Trinity College Dublin (FTCD) 2024
• Catalan Respiratory Medicine Association (FUCAP) 2003
• Innovation Award CRANN 2010
• Spanish Respiratory Medicine Association (SEPAR) 2002
• Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015
• Catalan Respiratory Medicine Association (SOCAP) 2003

• Irish Association of Pharmacologists (IAP) date
• COST Action 17140 'Cancer nanomedicine - from the bench to the bedside'(NANO2CLINIC) date
• Spanish Respiratory Medicine Association (SEPAR) date
• Member and co-founder of the Spanish Research Society in Ireland date

• Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis
• Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis
• Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis
• Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis