Professor Jeffrey O'Sullivan

• O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54Journal Article, 2015, DOI , TARA - Full Text
• Carvalho LF, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Byrne HJ, Lyng FM, Raman micro-spectroscopy for rapid screening of oral squamous cell carcinoma., Experimental and molecular pathology, 98, (3), 2015, p502-9Journal Article, 2015, DOI
• Sinevici N, O'sullivan J, Oral cancer: Deregulated molecular events and their use as biomarkers, Oral Oncology, 61, 2016, p12 - 18Journal Article, 2016, DOI , URL
• Carvalho L.F.C.S, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto L.P.M, Soto C.A.T, Dos Santos L, Martin A.A, Byrne H.J, Lyng F.M, Raman spectroscopic analysis of oral squamous cell carcinoma and oral dysplasia in the high-wavenumber region, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2015, 9531, 2015Conference Paper, 2015, DOI , URL
• Al Ghazal L, O'Sullivan J, Claffey N, Polyzois I, Comparison of two different techniques used for the maintenance ofperi-implant soft tissue health: a pilot randomized clinical trial., Acta Odontologica Scandinavica , 75, (7), 2017, p542-549Journal Article, 2017, DOI
• Carvalho LFCS, Bonnier F, Tellez C, Dos Santos L, O'Callaghan K, O'Sullivan J, Soares LES, Flint S, Martin AA, Lyng FM, Byrne HJ., Raman spectroscopic analysis of oral cells in the high wavenumber region., Experimental and molecular pathology, 103, (3), 2017, p255-262Journal Article, 2017, DOI
• Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma,Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Maria Rosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Sullivan, Lucia Morbidelli, Roberta Spaccapelo, Cosima Baldari, Stefania Butini, Ettore Novellino, Giuseppe Campiani, Lucia Altucci, Michel Steinmetz, Simone Brogi, Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, p290-320Journal Article, 2019, DOI , URL , TARA - Full Text
• Shanahan, P. and O'Sullivan, J. and Tipton, K.F. and Kinsella, G.K. and Ryan, B.J. and Henehan, G.T.M., Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase, Journal of Food Biochemistry, 2019, pe12697-Journal Article, 2019, DOI , URL
• Sinevici N, Mittermayer S, Davey GP, Bones J, O'Sullivan J, Salivary N-glycosyalation as a biomarker of Oral Cancer: A pilot study., Glycobiology, 2019Journal Article, 2019, DOI
• A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O'Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella Di Costanzo, Fulvio Saccoccia, Giovina Ruberti, Manfred Jung, Lucia Altucci, Sandra Gemma, Stefania Butini, David W. Christianson, and Giuseppe Campiani, Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation , ACS Medicinal Chemistry Letters, 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Carvalho LFCS, Dos Santos L, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto LPM, Martin AA, Lyng FM, Byrne HJ., Can ethanol affect the cell structure? A dynamic molecular and Raman spectroscopy study., Photodiagnosis and photodynamic therapy, 30, 2020, p101675Journal Article, 2020, DOI
• Bennett JH, Beeley JA, Anderson P, Belfield L, Brand HS, Didilescu AC, Dymock D, Guven Y, Hector MP, Holbrook P, Jayasinghe JAP, O'Sullivan J, Riggio M, Roger-Leroi V, Scheven B, Sloan AJ, Vandamme K, Manzanares MC., A core curriculum in the biological and biomedical sciences for dentistry., European journal of dental education : official journal of the Association for Dental Education in Europe, 24, (3), 2020, p433-441Journal Article, 2020, DOI
• Haj Ahmed W, Peiro C, Fontaine J, Ryan BJ, Kinsella GK, O'Sullivan J, Grolleau JL, Henehan GTM, Carpéné C., Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue., Medicines (Basel), 7, (4), 2020Journal Article, 2020, DOI
• Sinevici N, Harte N, O'Grady I, Xie Y, Min S, Hun Mok K, O'Sullivan J., The novel therapeutic potential of bovine "-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2020Journal Article, 2020, DOI
• Ibrahim O, O'Sullivan J., Iron chelators in cancer therapy., Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 33, (4-5), 2020, p201-215Journal Article, 2020, DOI
• O'Grady I, Anderson A, O'Sullivan J., The interplay of the oral microbiome and alcohol consumption in oral squamous cell carcinomas., Oral oncology, 110, 2020, p105011Journal Article, 2020, DOI
• Ahmed WH, Boulet N, Briot A, Ryan BJ, Kinsella GK, O'Sullivan J, Les F, Mercader-Barceló J, Henehan GTM, Carpéné C., Novel Facet of an Old Dietary Molecule? Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes., Molecules (Basel, Switzerland), 26, (13), 2021Journal Article, 2021, DOI
• Magnano S, Hannon Barroeta P, Duffy R, O'Sullivan J, Zisterer DM., Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species., Toxicology and applied pharmacology, 427, 2021, p115646Journal Article, 2021, DOI
• Anderson A, O'Sullivan J., The two faces of autophagy in oral squamous cell carcinoma, Archives of Oral Biology, 2022Journal Article, 2022, DOI
• O'Grady I, O'Sullivan J., Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression., Journal of oral biosciences, 2023, pS1349-0079(23)00130-5Journal Article, 2023, DOI , TARA - Full Text
• O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F., Davey, G., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, Suppl, (71), 2007, p105 - 112Journal Article, 2007
• O'Sullivan J, O'Sullivan M, Tipton K F, Unzeta M, Hernandez M, Davey G, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses. , Biochemica et biophysica acta, Apr 11, (1647), 2003, p367 - 371Journal Article, 2003
• O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF., Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do., Neurotoxicology, Jan 25, (1-2), 2004, p303 - 315Journal Article, 2004
• Tipton KF, O'Sullivan M, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochemical Society Transactions, Jun:31, (Pt. 3), 2003, p711 - 715Journal Article, 2003
• Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J, Monoamine oxidases: Certainties and uncertainties, Current Medicinal Chemistry, Aug 11, (15), 2004, p1965 - 1982Journal Article, 2004
• Monoamine oxidase (MAO):functions in the central nervous system in, editor(s)George Adelman And Barry H. Smith. , Encylopedia of Neuroscience 2004 , Elsevier, 2004, [Tipton KF, O'Sullivan J. Youdim MBH]Book Chapter, 2004
• Jeff O'Sullivan, Gavin Davey, Michael O'Sullivan and Keith F. Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, Journal of Neural Transmission, 6, (114), 2007, p751 - 756Journal Article, 2007
• Aldo Olivieri, Keith Tipton and Jeff O'Sullivan, L-Lysine as a recognition molecule for the VAP-1 function of SSAO, Journal of Neural Transmission, 6, (114), 2007, p747 - 749Journal Article, 2007
• Copper amine oxidases: structures, catalytic mechanisms and role in pathophysiology in, editor(s)Giovanni Floris Bruno Mondovi , Nomenclature and Potential Functions of the Mammalian Copper Amine Oxidases, London, Taylor & Francis Group, 2008, [Boyce S, Tipton KF, O'Sullivan M I, Davey G P, Motherway Gildea M, McDonald A G, Olivieri A, O'Sullivan J]Book Chapter, 2008
• Olivieri A, Davey G, O'Sullivan M I, Tipton K F, Boyce S, McDonald A G, O'Sullivan J(ed.), European Conference on Chemistry for Life Sciences, Poland, 2007, 2008, 51-57 pProceedings of a Conference, 2008
• Andrew McDonald, Keith Tipton, Jeff O'Sullivan, Aldo Olivieri, Gavin Davey, Anne-marie Coonan and Wenhao Fu, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, (6), 2007, p783 - 786Journal Article, 2007
• Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947Journal Article, 2010, DOI , URL , TARA - Full Text
• Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947Journal Article, 2010, DOI
• Olivieri A, Rico D, Khiari Z, Henehan G, O'Sullivan J, Tipton K, From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase., Journal of neural transmission (Vienna, Austria : 1996), 118, (7), 2011, p1079-1089Journal Article, 2011, DOI
• Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487Journal Article, 2012, DOI

• Magnano, S., O'Sullivan, J. and Zisterer, D.M., Pre-clinical evaluation of targeting autophagy for the treatment of Oral Squamous Cell Carcinoma , IADR Irish Divison, Belfast, November 2nd 2017, 2017Poster

Oral Cancer; Oral inflammation; Amine Oxidases, Protein Science

• Title

  The influence of Periodontitis in Diabetes
  Summary
• Title

  The role of dental pulp stem cells in neurotrophic support
  Summary
• Title

  The development of in-vitro models of alcohol induced oral carcinogenesis
  Summary
  Funding Agency

  Dublin Dental University Hospital/ Trinity College Dublin
  Date From

  Oct 2010
• Title

  Cloning and charaterisation of dental pulp SSAO
  Summary

Biochemistry and cell biology, Other health sciences, Cancer,

• Irish Society of Toxicology Scholarship 2001

• European Association for Cancer Research
• Association of Basic Science Teachers in Dentistry
• International Association of Dental Research
• Institute of Physics (IoP)
• Biochemistry Society

• ASEiD Council Member 2011
• ASEiD Council Member 2011
• Irish Division IADR Council Member President 2018-19 2012
• Irish Division IADR Council Member President 2018-19 2012
• ASEiD Council Member 2011
• ASEiD Council Member 2011
• Irish Division IADR Council Member President 2018-19 2012
• Irish Division IADR Council Member President 2018-19 2012