Dr. John Southern
Assistant Professor, Chemistry
Email southerj@tcd.ie Phone3531896 3411http://people.tcd.ie/southerjPublications and Further Research Outputs
- Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603Journal Article, 2015, URL
- Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039Journal Article, 2017, URL
- David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798Journal Article, 2016, URL
- I. E. Markó and J. M. Southern, Triorganothallium Reagents in Organic Chemistry. 1. A Simple, Efficient and Versatile Preparation of Ketones from Acid Chlorides, Journal of Organic Chemistry, 55, 1991, p3368-Journal Article, 1991
- Ian A. O'Neil, Ed Cleator, J. Mike Southern and David J. Tapolczay, The Stereospecific Addition of Hydroxylamines to a,b-Unsaturated Sulfones, Nitriles and Nitro compounds, Tetrahedron Letters, 42, 2001, p8251-Journal Article, 2001
- Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclisation., Synlett, 2000, p1408-Journal Article, 2000
- Ian A. O'Neil, J. Mike Southern, J. Chris Woolley and Heather Hobbs, The Synthesis of b-N-Tosylaminohydroxylamines via the Ring Opening of N-Tosylaziridines and Their Use in Reverse-Cope Cyclisations, Tetrahedron Letters, 42, 2001, p8243-Journal Article, 2001
- Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Chiral Functionalised Piperidines Using a Reverse-Cope Cyclisation: The Effect of Solvent on Diastereoselectivity, Synlett, 2000, p695-Journal Article, 2000
- Ian A. O'Neil, Andrew J. Potter, J. Mike Southern, Alexander Steiner and James V. Barkley, Conformationally Defined Piperazine bis(N-Oxides) Bearing Amino Acid Side Chains., Chemical Communications, 1998, p2511-Journal Article, 1998
- Ian A. O'Neil and J. Mike Southern, The Synthesis of Functionalised b-Hydroxyhydroxylamines via the Ring Opening of Epoxides and Their Use in Reverse-Cope Cyclisations., Tetrahedron Letters, 39, 1998, p9089-Journal Article, 1998
- Ian A. O'Neil and J. Mike Southern, A New Tin Mediated Pummerer Synthesis of Vinyl Stannanes., Synlett, 1997, p1165-Journal Article, 1997
- I. E. Markó, J. M. Southern and H. Adams, Towards the Total Synthesis of Manzamines. Rapid and Efficient Assembly of a Middle Core Model, Tetrahedron Letters, 33, 1992, p4657-Journal Article, 1992
- I. E. Markó, J. M. Southern and M. L. Kantam, Stoichiometric C-C Bond Formation Using Triorganothallium Reagents., Synlett, 1991, p235-Journal Article, 1991
- Preparation and reactions of iminophosphoranes and their synthetic applications in the aza-Wittig reaction. in, editor(s)P.J. Murphy , Organophosphorus Reagents A Practical Approach in Chemistry, Oxford University Press, 2004, pp151 - [J.Mike Southern and Ian A. O'Neil]Book Chapter, 2004
- Mangan D., Mcnabola N., Clark E.H., Bermudez I., Wonnacott S., Southern J.M., Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues, Organic and Biomolecular Chemistry, 17, (46), 2019, p9892 - 9905Journal Article, 2019, DOI
- Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918Journal Article, 2020, DOI , URL , TARA - Full Text
- McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022Journal Article, 2022, DOI , TARA - Full Text
- Introduction to Aromatic Chemistry in, editor(s)Chris Rostron, Jill Barber , Pharmaceutical Chemistry, Second Edition, Oxford University Press, 2021, pp208 - 243, [Mike Southern]Book Chapter, 2021
- Cotter M., Quinn S.M., Fearon U., Ansboro S., Rakovic T., Southern J.M., Kelly V.P., Connon S.J., A new class of 7-deazaguanine agents targeting autoimmune diseases: dramatic reduction of synovial fibroblast IL-6 production from human rheumatoid arthritis patients and improved performance against murine experimental autoimmune encephalomyelitis, RSC Medicinal Chemistry, 15, (5), 2024, p1556 - 1564, p1556-1564Journal Article, 2024, DOI
- O'Connor, CJ, Roydhouse, MD, Przybyl, AM, Wall, MD, Southern, JM, Facile Synthesis of 3-Nitro-2-substituted Thiophenes, JOURNAL OF ORGANIC CHEMISTRY, 75, (8), 2010, p2534-2538Journal Article, 2010, DOI
- Southern, J. Mike; O'Neil, Ian A.; Kearns, Peter, A concise synthesis of highly functionalised 4-thiosugar derivatives, Synlett, 14, 2008, p2158 - 2160Journal Article, 2008
- S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2020, 12 August 2024Patent
- John Michael Southern and David Mangan, 'Derivatives of mecamylamine', Tomkins, 2013, 12 December 2022Patent, URL
Recognition
- Visiting Professor, Louvain-la-Neuve University, Belgium Jan-Apr 2006
- Textbook - Oxford University Press. This includes reviewing various editions of the Gold-Standard Medicinal Chemistry text book "Introduction to Medicinal Chemistry". Additionally, I review proposals for new books.
- Reviewer of Dublin City University's Periodic Programme Review - a review of the BSc in Chemical and Pharmacuetical Sciences. 2020