Professor David Grayson

• Shaw, J.W. Grayson, D.H. Rozas, I., Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines, European Journal of Organic Chemistry, 2014, (17), 2014, p3565 - 3569Journal Article, 2014, DOI , URL
• Shaw J.W, Barbance L, Grayson D.H, Rozas I, Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines, Tetrahedron Letters, 56, (35), 2015, p4990 - 4992Journal Article, 2015, DOI , URL
• Synthesis of guanidines and some of their biological applications in, editor(s)Philipp Selig , Topics in Heterocyclic Chemistry: Guanidines as Reagents and Catalysts, Switzerland, Springer, 2017, pp1 - 52, [J. W. Shaw, D. H. Grayson, I. Rozas]Book Chapter, 2017
• Gallagher E.T, Grayson D.H, Reactions of aldehydes with organozinc reagents derived from (E)-3-bromo- And ( E)-3-iodo-1-phenylsulfonylprop-1-ene, Arkivoc, 2014, (5), 2014, p420 - 429Journal Article, 2014, DOI , URL
• Eichler M.C, Grayson D.H, Ozonolysis of some 8-alkoxyquinolines, and synthesis of a precursor to the non-sedating antihistamine Claritin, Arkivoc, 2014, (6), 2014, p38 - 53Journal Article, 2014, DOI , URL
• Lewis F.W, Grayson D.H, An improved synthesis of 10-isobornylsultone, Tetrahedron Asymmetry, 25, (15), 2014, p1150 - 1152Journal Article, 2014, DOI , URL
• Eichler M.C, Grayson D.H, Huddleston J, O'Neill J.P, Stobbe-like condensation reactions of the anion of diethyl (2-carboethoxy)benzylphosphonate with some aromatic and heterocyclic aldehydes, 2014, -Miscellaneous, 2014, DOI , URL
• Jerome Fakhry and David H. Grayson, One-pot synthesis of α-phenylsulfinyl ketones by reaction of phenyl benzenethiosulfinate with enolate anions, and synthesis of sulfoxides and sulfides by its reaction with Grignard reagents., Tetrahedron, 74, (5), 2018, p556 - 563Journal Article, 2018
• W. Cocker and D. H. Grayson, A convenient preparation of (?)-b-3,4-epoxycarane., Tetrahedron Lett., 1969, p4451-Journal Article, 1969
• P. H. Boyle, W. Cocker, D. H. Grayson and P. V. R. Shannon, The Chemistry of Terpenes. Part XIV. Syntheses of (±)- and (+)-fenchone, and of (+)-cis-2,2,5-trimethyl-3-vinylcyclopentanone, a photoisomer of (-)-cis-caran-4-one, J. Chem. Soc., C, 1971, p2136-Journal Article, 1971
• W. Cocker and D. H. Grayson, The Chemistry of Terpenes. Part 23. Reaction of (+)-carane-3b,4a-diol with sulphuric acid., J. Chem. Soc., Perkin Trans. 1, 1978, p155-Journal Article, 1978
• W. Cocker, D. H. Grayson and N. W. A. Geraghty, The Chemistry of Terpenes. Part 25. A synthesis of car-2 - car-3- and car-3(10)-ene., J. Chem. Soc., Perkin Trans. 1, 1978, p1370-Journal Article, 1978
• D. H. Grayson, Regiospecific formation of a p-menthenone from (+)-a-3,4-epoxycarane., Proc. Roy. Irish Acad., 83B, 1983, p85-Journal Article, 1983
• D. H. Grayson, J. M. Kelly, E. M. Moran, W. A. Nevin, C. M. O?Connell, M. M. O?Kane, D. C. Pepper, J. G. Vos and A. Yague-Ferrer, Polymer-bound Porphyrins and Polymer-bound Coordination Compounds as Converters of Solar Energy into Chemical Fuels., Second EC Solar Energy R and D Programme, Project D, Final Report, 1984., 1984Journal Article, 1984
• P. McWilliam, Y. McKeown, M. Newell, S.Thompson, P. Lohman, B. Enger-Valk, P. Pouwels and D. H. Grayson, Molecular interaction of the aromatic carcinogen 2-nitrosofluorene with DNA., Proc. EC Contractor?s Meeting, Athens, 1985., 1985Journal Article, 1985
• M. S. Carson and D. H. Grayson, Monoterpenoids, Nat. Prod. Rep., 3, 1986, p251-Journal Article, 1986
• D. H. Grayson and E. D. Roycroft, Synthesis of butanolides via intramolecular acylative ring-opening reactions of 3-(tetrahydro-2-furyl)propanoic acid derivatives, J. Chem. Soc., Chem. Commun., 1992, p1296-Journal Article, 1992
• W. Cocker, D. H. Grayson and P. V. R. Shannon, Hydrocyanation of some a,b-unsaturated ketones, and the synthesis of some unusual isoxazoles., J. Chem. Soc., Perkin Trans. 1, 1995, p1153 - 1162Journal Article, 1995
• S. S. Kelly, P. M. Glynn, S. J. Madden and D. H. Grayson, Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine, J. Pharm. Sci., 92, 2003, p451 - 459Journal Article, 2003
• D. H. Grayson and S. H. O?Donnell, Addition of nucleophiles to (E)-3-phenylsulfonylprop-2-enenitrile: a route to b-substituted a,b-unsaturated nitriles and to acetals of cyanoacetaldehyde, ARKIVOC, 2003, p4 - 14Journal Article, 2003, URL
• E. T. Gallagher and D. H. Grayson, Reactions of lithiated (E)-3-halo-1-phenylsulfonylprop-1-enes and of (Z)-1-halo-3-phenylsulfonylprop-1-enes with aldehydes, Org. Biomol. Chem., 1, 2003, p1374 - 1381Journal Article, 2003
• D. Cunningham, D. H. Grayson, P. McArdle and J. Walsh, The bromination of (?)-camphorquinone, Tetrahedron: Asymmetry, 14, 2003, p1197 - 1200Journal Article, 2003
• D. H. Grayson, U. McCarthy and E. D. Roycroft, Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2?-furyl)propanoic acid derivatives to give butanolides: mechanism and scope, Org. Biomol. Chem., 1, 2003, p1930 - 1937Journal Article, 2003
• R. D. Gunning, M. Venkatesan, D. H. Grayson and J. M. D. Coey, Magnetic propertiers of CNX whiskers, Carbon, 44, 2006, p3213 - 3217Journal Article, 2006
• F. W. Lewis, G. Egron and D. H. Grayson, Unexpected formaiton of 10-iodo- and 10-chlorocamphor under halosulfonylation conditions, and convenient routes to 10-chloro- and 10-bromocamphor, Tetrahedron: Asymmetry, (20), 2009, p1531 - 1535Journal Article, 2009
• F. W. Lewis, M. C. Eichler and D. H. Grayson, Synthesis of b-amino alcohols via the reduction of lactamides derived from ethyl (2S)-lactate with borane-methyl sulfide, Synlett, (12), 2009, p1923 - 1928Journal Article, 2009
• David P. Power, Olivier Lozach, Laurent Meijer, David H. Grayson, Stephen J. Connon, Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones, Bioorganic & Medicinal Chemistry Letters, 20, (16), 2010, 4940-4944Journal Article, 2010, DOI , URL , TARA - Full Text
• A.J. Shaw, T.G. Harrison, S.J. Croker, M. Medley, L. Sellou, K.L. Shallcross, S.J Williams, D.H. Grayson, D.E. Shallcross, University-School Partnerships: on the impact on students of Summer Schools (for school students aged 17-18) run by Bristol ChemLabS, Acta Didactica Napocensia, 3, (4), 2010, p35-48Journal Article, 2010, URL , TARA - Full Text
• Frank W. Lewis, Thomas C. McCabe, David H. Grayson, Preliminary investigations on novel camphor-derived chiral sulfones: completely stereoselective formation of tricyclic β-hydroxysulfones from 8- and 10- functionalized camphor derivatives, Tetrahedron, 67, (39), 2011, p7517-7528Journal Article, 2011, DOI , URL , TARA - Full Text
• Frank W. Lewis and David H. Grayson, The diastereoselective Meth-Cohn epoxidation of camphor-derived vinyl sulfones, Tetrahedron: Asymmetry, 23, (9), 2012, p643 - 649Journal Article, 2012
• J. Shaw, I. Rozas, D.H. Grayson, Synthesis of cyclic guanidines: 2-arylamino-1,4,5,6-tetrahydropyrimidines, Arkivoc, ii, 2014, p161-174Journal Article, 2014, DOI , TARA - Full Text

Development of new methods for organic synthesis; synthesis of complex natural products, especially medium-ring and macrocyclic lactones; cycloaddition chemistry of vinylic sulfones; chemistry of sulfonyl-stabilised anions; chiral auxiliaries and reagents derived from monoterpenoids; heterocyclic chemistry, especially the chemistry of 4-dimethylaminopyridine N-oxide and some homochiral derivatives.

• Title

  · Synthesis of macrocyclic lactones (Lawrence Cook)
  Summary

• CChem FRSC