Dr. Nigel Stevenson

• Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263Journal Article, 2014, DOI , URL
• Lui PY, Jin DY, Stevenson NJ., MicroRNA: master controllers of intracellular signaling pathways., Cellular and Molecular Life Sciences, 72, (18), 2015, p3531 - 3542Review Article, 2015, URL , TARA - Full Text
• Murray C1, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C., Brain, Behaviour and Immunity,, 48, 2015, p274 - 286Journal Article, 2015, URL , TARA - Full Text
• Mahony R, Ahmed S, Diskin C, Stevenson NJ, SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?, Cellular and Molecular Life Sciences, 73, (17), 2016, p3323 - 3336Review Article, 2016, TARA - Full Text
• Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764Journal Article, 2017, DOI , TARA - Full Text
• Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, (14), 2017, p2525-2535Review Article, 2017, DOI , TARA - Full Text
• Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216Journal Article, 2018, DOI , URL , TARA - Full Text
• Stevenson, Nigel, Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation, The Journal of Biological Chemistry, 280, (36), 2005, p31478 - 31488Journal Article, 2005, DOI
• Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C and Stevenson NJ, The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3, The FASEB Journal, 33, (8), 2019, p8732 - 8744Journal Article, 2019, TARA - Full Text
• Efstathiou C, Abidi SH, Harker J and Stevenson NJ., Revisiting Respiratory Syncytial Virus's Interaction with Host Immunity, Towards Novel Therapeutics, Cellular and Molecular Life Sciences, 2020Journal Article, 2020
• Zhang, Y. and Gargan, S. and Roche, F.M. and Frieman, M. and Stevenson, N.J., Inhibition of the IFN-α JAK/STAT Pathway by MERS-CoV and SARS-CoV-1 Proteins in Human Epithelial Cells, Viruses, 14, (4), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Wahaab, A. and Mustafa, B.E. and Hameed, M. and Stevenson, N.J. and Anwar, M.N. and Liu, K. and Wei, J. and Qiu, Y. and Ma, Z., Potential role of flavivirus ns2b-ns3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: A review, Viruses, 14, (1), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Alqahtani, M. and Mallah, S.I. and Stevenson, N. and Doherty, S., Vaccine trials during a pandemic: potential approaches to ethical dilemmas, Trials, 22, (1), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Gargan, S. and Stevenson, N.J., Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease, Viruses, 13, (11), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Almadhi, M.A. and Abdulrahman, A. and Sharaf, S.A. and AlSaad, D. and Stevenson, N.J. and Atkin, S.L. and AlQahtani, M.M., The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19, International Journal of Infectious Diseases, 105, 2021, p656-661Journal Article, 2021, DOI , URL , TARA - Full Text
• Zhang, Y. and Gargan, S. and Lu, Y. and Stevenson, N.J., An overview of current knowledge of deadly covs and their interface with innate immunity, Viruses, 13, (4), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• The interplay between the immune system and viruses in, 2021, pp1-15 , [Wubben, R. and Efstathiou, C. and Stevenson, N.J.]Book Chapter, 2021, DOI
• Farid, E. and Herrera-Uribe, J. and Stevenson, N.J., The Effect of Age, Gender and Comorbidities Upon SARS-CoV-2 Spike Antibody Induction After Two Doses of Sinopharm Vaccine and the Effect of a Pfizer/BioNtech Booster Vaccine, Frontiers in Immunology, 13, (817597), 2022Journal Article, 2022, DOI , URL
• Herrera-Uribe J, Naylor P, Rajab E Coskuner G, Jassim MS Jassim, Al-Qahtani M & Stevenson NJ., Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain., Journal of Hazardous Material Advances, 7, 2022, p1 - 9, p1-9Journal Article, 2022, URL , TARA - Full Text
• Ashraf, M.A. and Mustafa, B.E. and Wahaab, A. and Batool, H. and Ashraf, M. and Said, M.B. and Sevinc, F. and Stevenson, N.J., Conventional and molecular diagnosis of parasites, 2023, 56-72ppBook, 2023, DOI , URL
• Jeremiah, S.S. and Das, P. and Venkatesan, M. and Albinzayed, R. and Ahmed, A. and Stevenson, N.J. and Corbally, M. and Alqahtani, M. and Al-Wedaie, F. and Farid, E. and Hejres, S., Humoral and Innate Immunological Profile of Paediatric Recipients of Pfizer-BioNTech BNT162b2 mRNA Vaccine, Microorganisms, 12, (7), 2024Journal Article, 2024, DOI , URL
• Herrera-Uribe, Juber and Convery, Orla and ALmohammadi, Daniah and Weinberg, Fabienne Ingrid and Stevenson, Nigel J., The Neglected Suppressor of Cytokine Signalling (SOCS): SOCS4-7, Inflammation, 2024Journal Article, 2024, DOI , URL
• Zhang, Y. and Kandwal, S. and Fayne, D. and Stevenson, N.J., MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation, Cellular and Molecular Life Sciences, 81, (1), 2024Journal Article, 2024, DOI , URL
• Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866Journal Article, 2011, DOI , URL , TARA - Full Text
• Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578Journal Article, 2013, DOI , TARA - Full Text
• Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851Journal Article, 2011, DOI , TARA - Full Text
• De La Vega, M., Kelvin, A.A., Dunican, D.J., McFarlane, C., Burrows, J.F., Jaworski, J., Stevenson, N.J., Dib, K., Rappoport, J.Z., Scott, C.J., Long, A., Johnston, J.A., The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility, Nature Communications, 2, (1), 2011, p259Journal Article, 2011, DOI , TARA - Full Text
• Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832Journal Article, 2010, DOI , TARA - Full Text
• Stevenson, N.J., Addley, M.R., Ryan, E.J., Boyd, C.R., Carroll, H.P., Paunovic, V., Bursill, C.A., Miller, H.C., Channon, K.M., McClurg, A.E., Armstrong, M.A., Coulter, W.A., Greaves, D.R., Johnston, J.A., CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression, Journal of Leukocyte Biology, 85, (2), 2009, p289-297Journal Article, 2009, DOI , TARA - Full Text
• Elliott, J., Lynch, O.T., Suessmuth, Y., Qian, P., Boyd, C.R., Burrows, J.F., Buick, R., Stevenson, N.J., Touzelet, O., Gadina, M., Power, U.F., Johnston, J.A., Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase, Journal of Virology, 81, (7), 2007, p3428-3436Journal Article, 2007, DOI , TARA - Full Text
• Sommer, U., Schmid, C., Sobota, R.M., Lehmann, U., Stevenson, N.J., Johnston, J.A., Schaper, F., Heinrich, P.C., Haan, S., Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases, Journal of Biological Chemistry, 280, (36), 2005, p31478-31488Journal Article, 2005, DOI , TARA - Full Text
• Stevenson, N.J., Haan, S., McClurg, A.E., McGrattan, M.J., Armstrong, M.A., Heinrich, P.C., Johnston, J.A., The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression, Journal of Immunology, 173, (5), 2004, p3243-3249Journal Article, 2004, TARA - Full Text
• Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63Journal Article, 2014, DOI , TARA - Full Text
• Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090Journal Article, 2013, DOI , TARA - Full Text
• The Role of the Immune System in Cancer. in, Infection in the cancer patient., Oxford University Press, 2006, pp19 - 41, [Stevenson NJ and Johnston JA. ]Book Chapter, 2006
• Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-Journal Article, 2014, DOI , TARA - Full Text
• HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments, OMICS group, 2014, [Napoletano S, Bannan C, Bergin C and Stevenson NJ]Book Chapter, 2014, DOI

• Kelly A, Fahey R, Keogh C, Stevenson NJ, CarrollA , Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O'Farrelly C, Cd141+ (bdca-3+) interferon lambda (ifn-λ)-producing dendritic cells are depleted in hepatitis C virus-infected liver, Immunology, 2011, 135, 2011, pp111Conference Paper
• Stevenson NJ, Haan S, McClurg AE, McGrattan MJ, Armstrong MA, Heinrich PC, JA Johnston, The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine, Journal of Immunology, 173, (5), 2004, pp3243 - 3249Conference Paper
• Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744Journal Article, DOI
• Stevenson NJ, Ryan EJ, Keogh CA, Lloyd AT, Cormican P, Hegarty JE, O'Farrelly C. , Hepatitis C virus (HCV) regulates signal transducer and activator of transcription (STAT) protein expression to escape interferon-alpha (IFN-alpha) responses. , Immunology, 125, (1), 2008, pp71Conference Paper
• Stevenson NJ, Addely M, Greaves D, Johnston J. , Chemokines regulate innate immunity and chemotaxis through Suppressor Of Cytokine Signalling (SOCS) proteins., Clinical Immunology, 2006, ppS127Conference Paper
• Stevenson NJ, Haan S, McClurg A, Armstrong MA, Heinrich P, Johnston JA. , The chemoattractants IL-8 and fMLP regulate G-CSF signalling by inducing suppressor of cytokine signalling (SOCS)-1 expression., Immunology, 116, (1), 2005, pp73Conference Paper
• Armstrong MA, McClurg AE, Stevenson NJ, Hawkins SA, Johnston JA. , Timing of exposure to interferon beta can alter conventional dendritic cell precursor cell differentiation by upregulating IKBzeta and downregulating NFkB2/p52. , Immunology, 120, (1), 2007, pp36Conference Paper

Clinical Medicine, Medical, health and life sciences, Microbiology, Biochemistry and cell biology, Agricultural, veterinary and food sciences, Immunology,