Trinity Biomedical Sciences Institute

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152-160 Pearse Street
Trinity College Dublin
Dublin 2
Ireland

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Professor Cliona O'Farrelly

Professor Cliona O'Farrelly

Chair in Comparative Immunology, Biochemistry

Chair in Comparative Immunology, Clinical Medicine

3531896 3175

Publications and Further Research Outputs

  • Murphy, T.M. O'Donovan, A. Mullins, N. O'Farrelly, C. McCann, A. Malone, K., Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes, Psychiatric Genetics, 25, (2), 2015, p71 - 78Journal Article, 2015, DOI , URL
  • Lawless, N. Vegh, P. O'Farrelly, C. Lynn, D.J., The role of microRNAs in bovine infection and immunity, Front. Immunol., 5, (NOV), 2014, p611-Journal Article, 2014, DOI , URL , TARA - Full Text
  • Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263Journal Article, 2014, DOI , URL
  • O'Farrelly C, Just how inflamed is the normal gut?, Gut, 42, (5), 1998, p603-4Journal Article, 1998, TARA - Full Text
  • Davies D, Meade KG, Herath S, Eckersall PD, Gonzalez D, White JO, Conlan RS, O'Farrelly C, Sheldon IM, Toll-like receptor and antimicrobial peptide expression in the bovine endometrium., Reproductive biology and endocrinology : RB&E, 6, 2008, p53Journal Article, 2008, DOI , TARA - Full Text
  • Foley C, Chapwanya A, Callanan JJ, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer WG, Lynn DJ, O' Farrelly C, Meade KG, Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis., BMC genomics, 16, 2015, p811Journal Article, 2015, DOI , TARA - Full Text
  • Kelly A, Robinson M.W, Roche G, Biron C.A, O'Farrelly C, Ryan E.J, Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway, Journal of Interferon and Cytokine Research, 36, (12), 2016, p671 - 680Journal Article, 2016, DOI , URL
  • Rush G, O'Donovan A, Nagle L, Conway C, McCrohan A, O'Farrelly C, Lucey J.V, Malone K.M, Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy, Journal of Affective Disorders, 205, 2016, p60 - 68Journal Article, 2016, DOI , URL
  • Doherty R, Whiston R, Cormican P, Finlay E.K, Couldrey C, Brady C, O'Farrelly C, Meade K.G, The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle, Scientific Reports, 6, 2016, p31014Journal Article, 2016, DOI , URL , TARA - Full Text
  • Harmon C, Robinson M.W, Fahey R, Whelan S, Houlihan D.D, Geoghegan J, O'Farrelly C, Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver, European Journal of Immunology, 46, (9), 2016, p2111 - 2120Journal Article, 2016, DOI , URL
  • Conroy M.J, Galvin K.C, Kavanagh M.E, Mongan A.M, Doyle S.L, Gilmartin N, O'Farrelly C, Reynolds J.V, Lysaght J, CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer, Immunology and Cell Biology, 94, (6), 2016, p531 - 537Journal Article, 2016, DOI , URL
  • Robinson M.W, Harmon C, O'Farrelly C, Liver immunology and its role in inflammation and homeostasis, Cellular and Molecular Immunology, 13, (3), 2016, p267 - 276Journal Article, 2016, DOI , URL , TARA - Full Text
  • Fischer J, Weber A.N.R, Bohm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-MÃ"ller E, Malinverni R, Bochud P.-Y, Gardiner C, O'Farrelly C, Berg T, Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection, Gut, 2016Journal Article, 2016, DOI , URL
  • Thiruchelvam U, Wingfield M, O'Farrelly C, Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor, American Journal of Reproductive Immunology, 75, (4), 2016, p493 - 502Journal Article, 2016, DOI , URL
  • Coughlan A.M, Harmon C, Whelan S, O'Brien E.C, O'Reilly V.P, Crotty P, Kelly P, Ryan M, Hickey F.B, O'Farrelly C, Little M.A, Myeloid engraftment in humanized mice: Impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain, Stem Cells and Development, 25, (7), 2016, p530 - 541Journal Article, 2016, DOI , URL
  • Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan D.D, Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?, American Journal of Transplantation, 16, (3), 2016, p751 - 757Journal Article, 2016, DOI , URL
  • Johnson G.P, Lloyd A.T, O'Farrelly C, Meade K.G, Fair S, Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract, Reproduction, Fertility and Development, 28, (10), 2016, p1499 - 1508Journal Article, 2016, DOI , URL
  • Foley C, Chapwanya A, Callanan J.J, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer W.G, Lynn D.J, O'Farrelly C, Meade K.G, Erratum to: 'Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis'[BMC Genomics. 2015;16:811.], 2015, -Miscellaneous, 2015, DOI , URL
  • Fitzmaurice K, Hurst J, Dring M, Rauch A, McLaren P.J, GÃŒnthard H.F, Gardiner C, Klenerman P, Courtney G, Crosbie O, Crowe J, Fanning L, Hegarty J, Kelleher D, Lawlor E, Lee J, McKiernan S, Murray F, Norris S, O'Farrelly C, Thornton L, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H.C, Burton-Jeangros C, Calmy A, Cavassini M, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux C.A, Gorgievski M, Haerry D, Hasse B, Hirsch H.H, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Ledergerber B, Martinetti G, Martinez De Tejada B, Metzner K, MÃŒller N, Nadal D, Pantaleo G, Regenass S, Rickenbach M, Rudin C, Schöni-Affolter F, Schmid P, Schultze D, SchÃŒpbach J, Speck R, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection, Gut, 64, (5), 2014, p813 - 819Journal Article, 2014, DOI , URL
  • Thiruchelvam U, Wingfield M, O'Farrelly C, Natural Killer Cells: Key Players in Endometriosis, American Journal of Reproductive Immunology, 74, (4), 2015, 291-301Journal Article, 2015, URL
  • Conroy M.J, Fitzgerald V, Doyle S.L, Channon S, Useckaite Z, Gilmartin N, O†Farrelly C, Ravi N, Reynolds J.V, Lysaght J, The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function, Journal of Leukocyte Biology, 100, (6), 2016, p1435 - 1442Journal Article, 2016, DOI , URL
  • Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764Journal Article, 2017, DOI , TARA - Full Text
  • *Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238Journal Article, 2018, DOI , URL
  • Glover, L.E. and Crosby, D. and Thiruchelvam, U. and Harmon, C. and Chorcora, C.N. and Wingfield, M.B. and O'Farrelly, C., Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis-associated infertility, American Journal of Reproductive Immunology, 2018, pe12817-Journal Article, 2018, DOI , URL
  • Whiston, R. and Finlay, E.K. and McCabe, M.S. and Cormican, P. and Flynn, P. and Cromie, A. and Hansen, P.J. and Lyons, A. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility, Scientific Reports, 7, (1), 2017, p12287 -Journal Article, 2017, DOI , URL , TARA - Full Text
  • Garvey, P. and Murphy, N. and Flanagan, P. and Brennan, A. and Courtney, G. and Crosbie, O. and Crowe, J. and Hegarty, J. and Lee, J. and McIver, M. and McNulty, C. and Murray, F. and Nolan, N. and O'Farrelly, C. and Stewart, S. and Tait, M. and Norris, S. and Thornton, L., Disease outcomes in a cohort of women in Ireland infected by hepatitis C-contaminated anti-D immunoglobulin during 1970s, Journal of Hepatology, 67, (6), 2017, p1140-1147Journal Article, 2017, DOI , URL
  • Adnane, M. and Chapwanya, A. and Kaidi, R. and Meade, K.G. and O'Farrelly, C., Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?, Theriogenology, 103, 2017, p117-122Journal Article, 2017, DOI , URL
  • Hall, T.J. and McQuillan, C. and Finlay, E.K. and O'Farrelly, C. and Fair, S. and Meade, K.G., Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome, BMC Genomics, 18, (1), 2017, p278-Journal Article, 2017, DOI , URL , TARA - Full Text
  • Kennelly, K.P. and Holmes, T.M. and Wallace, D.M. and O†Farrelly, C. and Keegan, D.J., Early subretinal allograft rejection is characterized by innate immune activity, Cell Transplantation, 26, (6), 2017, p983-1000Journal Article, 2017, DOI , URL
  • Fernandez-Fuertes, B. and Narciandi, F. and O'Farrelly, C. and Kelly, A.K. and Fair, S. and Meade, K.G. and Lonergan, P., Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle, Biology of Reproduction, 95, (6), 2016, p1-12Journal Article, 2016, DOI , URL
  • Narciandi, F. and Fernandez-Fuertes, B. and Khairulzaman, I. and Jahns, H. and King, D. and Finlay, E.K. and Mok, K.H. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract, Biology of Reproduction, 95, (6), 2016, p1-9Journal Article, 2016, DOI , URL
  • Roche, J., Davis, N., Chaikovsky, M., O'Boyle, S., & O'Farrelly, C., European Researchers' Night as a Learning Environment, The International Journal of Interdisciplinary Educational Studies, 13, (1), 2018, p1 - 9Journal Article, 2018, DOI , TARA - Full Text
  • Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216Journal Article, 2018, DOI , URL , TARA - Full Text
  • Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346Journal Article, 2019, DOI , URL
  • Meade, K.G. and O'Farrelly, C., Î'-Defensins: Farming the microbiome for homeostasis and health, Frontiers in Immunology, 10, (JAN), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
  • Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, (FEB), 2019, p1--Journal Article, 2019, DOI , URL , TARA - Full Text
  • Adnane, M. and Kelly, P. and Chapwanya, A. and Meade, K.G. and O'Farrelly, C., Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle, BMC Veterinary Research, 14, (1), 2018Journal Article, 2018, DOI , URL , TARA - Full Text
  • L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90Journal Article, 1997, DOI
  • S. Lynch, D. Kelleher, R. McManus and C. O'Farrelly, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation, European journal of immunology, 25, (5), 1995, p1143-1147Journal Article, 1995, DOI
  • Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236Journal Article, 2022
  • Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022Journal Article, 2022, DOI , URL
  • Dyer AH, Fallon A, Noonan C, Dolphin H, O'Farrelly C, Bourke NM, O'Neill D, Kennelly SP, Managing The Impact Of COVID-19 in Nursing Homes and Long-Term Care Facilities: An Update, Journal of the American Medical Directors Association, 2022Journal Article, 2022
  • Posseme, Celine and Llibre, Alba and Charbit, Bruno and Bondet, Vincent and Rouilly, Vincent and Saint-André, Violaine and Boussier, Jeremy and Bergstedt, Jacob and Smith, Nikaïa and Townsend, Liam and Sugrue, Jamie A and Ní Cheallaigh, Clíona and Conlon, Niall and Rotival, Maxime and Kobor, Michael S and Mottez, Estelle and Pol, Stanislas and Patin, Etienne and Albert, Matthew L and Quintana-Murci, Lluis and Duffy, Darragh and {Milieu Intérieur Consortium, Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation, Cell reports, 39, (13), 2022, p110989Journal Article, 2022, DOI , URL
  • Sugrue JA, Posseme C, Tan Z, Pou C, Charbit B, Bondet V, Bourke NM, Brodin P, Duffy D, O'Farrelly C, Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort., Cell reports. Medicine, 2022Journal Article, 2022, DOI
  • Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023Journal Article, 2023, DOI
  • Ridge, Katie and Moran, Barry and Alvarado-Vazquez, P. Abigail and Hallgren, Jenny and Little, Mark A. and Irvine, Alan D. and O'Farrelly, Cliona and Dunne, Jean and co-senior). Finlay, Conor M (co-corresponding & and Conlon, Niall, Lin-CD117+CD34+FceRI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti-IgE therapy, Allergy, In Press, 2024Journal Article, 2024
  • Bertrand A, Sugrue J, Lou T, Bourke N.M, Quintana-Murci L, Saint-André V, O'Farrelly C, Duffy D, Impact of socioeconomic status on healthy immune responses in humans, Immunology and Cell Biology, 2024Journal Article, 2024, DOI
  • Villain E, Chanson A, Mainka M, Kampschulte N, Le Faouder P, Bertrand-Michel J, Brandolini-Bulon M, Charbit B, Musvosvi M, Bilek N, Scriba T.J, Quintana-Murci L, Schebb N.H, Duffy D, Gladine C, Abel L, Alcover A, Aschard H, Bousso P, Bourke N, Brodin P, Bruhns P, Cerf-Bensussan N, Cumano A, D'Enfert C, Deriano L, Dillies M.-A, Di Santo J, Eberl G, Enninga J, Fellay J, Gomperts-Boneca I, Hasan M, Hedestam G.K, Hercberg S, Ingersoll M.A, Lantz O, Kenny R.A, Ménager M, Mouquet H, O'Farrelly C, Patin E, Pellegrini S, Rausell A, Rieux-Laucat F, Rogge L, Fontes M, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Tangy F, Toubert A, Touvier M, Ungeheuer M.-N, Zimmer C, Albert M.L, Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks, iScience, 26, (8), 2023Journal Article, 2023, DOI
  • Sularea V.M, Sugrue J.A, O'Farrelly C, Innate antiviral immunity and immunometabolism in hepatocytes, Current Opinion in Immunology, 80, 2023Journal Article, 2023, DOI
  • Carroll H.K, Duffy A.G, O'Farrelly C, Liver Immunology, Immunotherapy, and Liver Cancers: Time for a Rethink?, Seminars in Liver Disease, 42, (2), 2022, p212 - 224Journal Article, 2022, DOI
  • Ahmed O, Xu M, Zhou F, Wein A.N, Upadhya G, Ye L, Wong B.W, Lin Y, O'Farrelly C, Chapman W.C, NRF2 assessment in discarded liver allografts: A role in allograft function and salvage, American Journal of Transplantation, 22, (1), 2022, p58 - 70Journal Article, 2022, DOI
  • Crosby D.A, Glover L.E, Downey P, Mooney E.E, McAuliffe F.M, O'Farrelly C, Brennan D.J, Wingfield M, Mid-luteal uterine artery Doppler indices in the prediction of pregnancy outcome in nulliparous women undergoing assisted reproduction, Human Fertility, 25, (4), 2022, p670 - 676Journal Article, 2022, DOI
  • Meade KG, Gormley E, O'Farrelly C, Park SD, Costello E, Keane J, Zhao Y, Machugh DE., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC Genomics, 29, (9), 2008, p447-Journal Article, 2008, DOI , TARA - Full Text
  • Meade, KG, Gormley, E, O'Farrelly, C, Park, SD, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC genomics, 9, (447), 2008Journal Article, 2008, DOI , URL
  • Meade, KG, Cahalane, S, Narciandi, F, Cormican, P, Lloyd, AT, O'Farrelly, C, Directed alteration of a novel bovine beta-defensin to improve antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA)., International journal of antimicrobial agents, 32, (5), 2008, p392-397Journal Article, 2008, DOI , URL
  • Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8Journal Article, 2008, DOI , URL
  • Cormican, P, Meade, KG, Cahalane, S, Narciandi, F, Chapwanya, A, Lloyd, AT, O'Farrelly, C, Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins., Immunogenetics, 60, (3-4), 2008, p147-156Journal Article, 2008, DOI , URL
  • Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40Journal Article, 2008, DOI , URL
  • Meade, KG, Gormley, E, Doyle, MB, Fitzsimons, T, O'Farrelly, C, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease., BMC genomics, 8, 2007, p400Journal Article, 2007, DOI , URL , TARA - Full Text
  • Zaman, MB, Leonard, MO, Ryan, EJ, Nolan, NP, Hoti, E, Maguire, D, Mulcahy, H, Traynor, O, Taylor, CT, Hegarty, JE, Geoghegan, JG, O'Farrelly, C, Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?, Transplantation, 84, (10), 2007, p1272-8Journal Article, 2007, DOI , URL
  • Golden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR, Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection., Journal of virology, 81, (17), 2007, p9292-9298Journal Article, 2007, DOI , URL , TARA - Full Text
  • Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26Journal Article, 2007, DOI , URL , TARA - Full Text
  • Leonard, MO, Kieran, NE, Howell, K, Burne, MJ, Varadarajan, R, Dhakshinamoorthy, S, Porter, AG, O'Farrelly, C, Rabb, H, Taylor, CT, Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006Journal Article, 2006, DOI , URL
  • Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72Journal Article, 2007, DOI , URL
  • Kelly, AM, Golden-Mason, L, Traynor, O, Geoghegan, J, McEntee, G, Hegarty, JE, O'Farrelly, C, Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity., Cytokine, 35, (3-4), 2006, p171-9Journal Article, 2006, DOI , URL
  • Cawood, TJ, Moriarty, P, O'Farrelly, C, O'Shea, D, The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis., European journal of endocrinology / European Federation of Endocrine Societies, 155, (3), 2006, p395-403Journal Article, 2006, DOI , URL , TARA - Full Text
  • Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204Journal Article, 2006, URL
  • Volkov, Y, Long, A, Freeley, M, Golden-Mason, L, O'Farrelly, C, Murphy, A, Kelleher, D, The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration., Gastroenterology, 130, (2), 2006, p482-92Journal Article, 2006, DOI , URL
  • Canny, G, Drudy, D, Macmathuna, P, O'Farrelly, C, Baird, AW, Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical., Life Sciences, 78, (9), 2006, p920-5Journal Article, 2006, DOI , URL
  • Dean, J, McCarthy, D, Lawler, M, Doherty, DG, O'Farrelly, C, Golden-Mason, L, Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical immunology (Orlando, Fla.), 114, (1), 2005, p42-51Journal Article, 2005, DOI , URL
  • Dean, J, McCarthy, D, Golden-Mason, L, O'Farrelly, C, Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells., Immunology letters, 99, (1), 2005, p94-102Journal Article, 2005, DOI , URL
  • Higgs, R, Lynn, DJ, Gaines, S, McMahon, J, Tierney, J, James, T, Lloyd, AT, Mulcahy, G, O'Farrelly, C, The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens., Immunogenetics, 57, (1-2), 2005, p90-8Journal Article, 2005, DOI , URL
  • Kenna, T, Golden-Mason, L, Norris, S, Hegarty, JE, O'Farrelly, C, Doherty, DG, Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver., Clinical immunology (Orlando, Fla.), 113, (1), 2004, p56-63Journal Article, 2004, DOI , URL
  • Varadarajan, R, Golden-Mason, L, Young, L, McLoughlin, P, Nolan, N, McEntee, G, Traynor, O, Geoghegan, J, Hegarty, JE, O'Farrelly, C, Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation., Transplantation, 78, (2), 2004, p250-6Journal Article, 2004, URL
  • Lynn, DJ, Higgs, R, Gaines, S, Tierney, J, James, T, Lloyd, AT, Fares, MA, Mulcahy, G, O'Farrelly, C, Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken., Immunogenetics, 56, (3), 2004, p170-177Journal Article, 2004, DOI , URL
  • O'Keeffe, J, Doherty, DG, Kenna, T, Sheahan, K, O'Donoghue, DP, Hyland, JM, O'Farrelly, C, Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer., European journal of immunology, 34, (8), 2004, p2110 - 2119Journal Article, 2004, DOI , URL
  • Golden-Mason, L, Kelly, AM, Doherty, DG, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development., Clinical and experimental immunology, 138, (1), 2004, p94-101Journal Article, 2004, DOI , URL , TARA - Full Text
  • Kelly, AM, Golden-Mason, L, McEntee, G, Traynor, O, Doherty, DG, Hegarty, JE, O'Farrelly, C, Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo., Cytokine, 25, (6), 2004, p273-282Journal Article, 2004, DOI , URL
  • Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779Journal Article, 2003, URL
  • Hayden, PJ, O'Brien, M, Collins, B, O'Farrelly, C, Murphy, K, Inherited thrombotic tendency in a pedigree with antithrombin La Rochelle (N405K) and factor V Leiden., Clinical and laboratory haematology, 25, (3), 2003, p191 - 193Journal Article, 2003, DOI , URL
  • Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535Journal Article, 2003
  • Smith, F, Golden-Mason, L, Deignan, T, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, J, O'Farrelly, C, Localization of T and B lymphocytes in histologically normal adult human donor liver., Hepato-gastroenterology, 50, (53), 2003, p1311-5Journal Article, 2003
  • Lynn, DJ, Lloyd, AT, O'Farrelly, C, In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)., Veterinary immunology and immunopathology, 93, (3-4), 2003, p177-84Journal Article, 2003, DOI , URL
  • Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50Journal Article, 2003, DOI , URL
  • Gaines, S, James, TC, Folan, M, Baird, AW, O'Farrelly, C, A novel spectrofluorometric microassay for Streptococcus mutans adherence to hydroxylapatite., Journal of microbiological methods, 54, (3), 2003, p315-23Journal Article, 2003, DOI , URL
  • Byrne, B, Madrigal-Estebas, L, McEvoy, A, Carton, J, Doherty, DG, Whelan, A, Feighery, C, O'Donoghue, DP, O'Farrelly, C, Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules., Human immunology, 63, (11), 2002, p977-86Journal Article, 2002, DOI , URL
  • Deignan, T, Curry, MP, Doherty, DG, Golden-Mason, L, Volkov, Y, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection., Journal of Hepatology, 37, (1), 2002, p101-8Journal Article, 2002, DOI , URL
  • Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8Journal Article, 2003, DOI , URL
  • Madrigal-Estebas, L, Doherty, DG, O'Donoghue, DP, Feighery, C, O'Farrelly, C, Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells., Mediators of inflammation, 11, (5), 2002, p313-319Journal Article, 2002, DOI , URL , TARA - Full Text
  • Drudy, D, O'Donoghue, DP, Baird, A, Fenelon, L, O'Farrelly, C, Flow cytometric analysis of Clostridium difficile adherence to human intestinal epithelial cells., Journal of medical microbiology, 50, (6), 2001, p526-34Journal Article, 2001, DOI , URL
  • Dunne, J, Lynch, S, O'Farrelly, C, Todryk, S, Hegarty, JE, Feighery, C, Doherty, DG, Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15., Journal of immunology (Baltimore, Md. : 1950), 167, (6), 2001, p3129-38Journal Article, 2001, URL
  • Golden-Mason, L, Douek, DC, Koup, RA, Kelly, J, Hegarty, JE, O'Farrelly, C, Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development., Journal of immunology (Baltimore, Md. : 1950), 172, (10), 2004, p5980-5Journal Article, 2004, URL
  • Lynn, DJ, Lloyd, AT, Fares, MA, O'Farrelly, C, Evidence of positively selected sites in mammalian alpha-defensins., Molecular biology and evolution, 21, (5), 2004, p819-827Journal Article, 2004, DOI , URL , TARA - Full Text
  • Carton, J, Byrne, B, Madrigal-Estebas, L, O'Donoghue, DP, O'Farrelly, C, CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease., European journal of gastroenterology & hepatology, 16, (10), 2004, p961-8Journal Article, 2004, URL
  • Golden-Mason, L, Kelly, AM, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development., Cytokine, 14, (3), 2001, p143-51Journal Article, 2001, DOI , URL
  • Golden-Mason, L, Curry, MP, Nolan, N, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver., Hepatology (Baltimore, Md.), 31, (6), 2000, p1251-6Journal Article, 2000, DOI , URL
  • Curry, MP, Norris, S, Golden-Mason, L, Doherty, DG, Deignan, T, Collins, C, Traynor, O, McEntee, GP, Hegarty, JE, O'Farrelly, C, Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization., Journal of Immunological Methods, 242, (1-2), 2000, p21-31Journal Article, 2000, DOI
  • Deignan, T, Alwan, A, Kelly, J, McNair, J, Warren, T, O'Farrelly, C, Serum haptoglobin: an objective indicator of experimentally-induced Salmonella infection in calves., Research in veterinary science, 69, (2), 2000, p153-8Journal Article, 2000, DOI , URL
  • Flynn, L, Byrne, B, Carton, J, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium., American journal of reproductive immunology (New York, N.Y. : 1989), 43, (4), 2000, p209-17Journal Article, 2000, DOI , URL
  • Curry, MP, Golden-Mason, L, Nolan, N, Parfrey, NA, Hegarty, JE, O'Farrelly, C, Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection., Journal of Hepatology, 32, (1), 2000, p121-5Journal Article, 2000, DOI , URL
  • Levelt, CN, de Jong, YP, Mizoguchi, E, O'Farrelly, C, Bhan, AK, Tonegawa, S, Terhorst, C, Simpson, SJ, High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes., Proceedings of the National Academy of Sciences of the United States of America, 96, (10), 1999, p5628-33.Journal Article, 1999, URL , TARA - Full Text
  • Abuzakouk, M, Feighery, C, Kelleher, D, O'Briain, DS, Jones, E, Weir, D, Casey, E, O'Farrelly, C, Increased HLA-DR and CD44 antigen expression in the gut: evidence of extraarticular immunological activity in rheumatoid arthritis., The Journal of Rheumatology, 26, (9), 1999, p1869-76Journal Article, 1999
  • Flynn, L, Carton, J, Byrne, B, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Optimisation of a technique for isolating lymphocyte subsets from human endometrium., Immunological investigations, 28, (4), 1999, p235-46Journal Article, 1999, URL
  • Costello, P, Bresnihan, B, O'Farrelly, C, FitzGerald, O, Predominance of CD8+ T lymphocytes in psoriatic arthritis., The Journal of rheumatology, 26, (5), 1999, p1117-24.Journal Article, 1999
  • Doherty, DG, Norris, S, Madrigal-Estebas, L, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns., Journal of immunology (Baltimore, Md. : 1950), 163, (4), 1999, p2314-21Journal Article, 1999, URL
  • Norris, S, Doherty, DG, Collins, C, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells., Human immunology, 60, (1), 1999, p20-31Journal Article, 1999, DOI , URL
  • Crosbie, OM, Reynolds, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, In vitro evidence for the presence of hematopoietic stem cells in the adult human liver., Hepatology (Baltimore, Md.), 29, (4), 1999, p1193-8Journal Article, 1999, DOI , URL
  • Feighery, C, Weir, DG, Whelan, A, Willoughby, R, Youngprapakorn, S, Lynch, S, O'Moráin, C, McEneany, P, O'Farrelly, C, Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate?, European journal of gastroenterology & hepatology, 10, (11), 1998, p919-25Journal Article, 1998
  • Crosbie, OM, Norris, S, Hegarty, JE, O'Farrelly, C, T lymphocyte subsets and activation status in patients following liver transplantation., Immunological investigations, 27, (4-5), 1998, p237-41Journal Article, 1998, URL
  • Crosbie, OM, Costello, PJ, O'Farrelly, C , Hegarty, JEC, Changes in peripheral blood double-negative T-lymphocyte (CD3+ CD4- CD8-) populations associated with acute cellular rejection after liver transplantation., Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 4, (2), 1998, p141-5Journal Article, 1998, DOI , URL
  • Srinivasan, U, Weir, DG, Feighery, C, O'Farrelly, C, Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration., BMJ (Clinical research ed.), 316, (7126), 1998, p206-7Journal Article, 1998, URL , TARA - Full Text
  • Abuzakouk, M, Carton, J, Feighery, C, O'Donoghue, DP, Weir, DG, O'Farrelly, C, CD4+ CD8+ and CD8alpha+ beta- T lymphocytes in human small intestinal lamina propria., European journal of gastroenterology & hepatology, 10, (4), 1998, p325-9Journal Article, 1998
  • Norris, S, Collins, C, Doherty, DG, Smith, F, McEntee, G, Traynor, O, Nolan, N, Hegarty, J, O'Farrelly, C, Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes., Journal of hepatology, 28, (1), 1998, p84 - 90Journal Article, 1998
  • Norris, S, Lawler, M, McCann, S, Hegarty, J, O'Farrelly, C, Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance., Hepatology (Baltimore, Md.), 26, (4), 1997, p848-52Journal Article, 1997, DOI , URL
  • Reynolds, JV, O'Farrelly, C, Feighery, C, Murchan, P, Leonard, N, Fulton, G, O'Morain, C, Keane, FB, Tanner, WA, Impaired gut barrier function in malnourished patients., The British journal of surgery, 83, (9), 1996, p1288-1291Journal Article, 1996, DOI , URL
  • Collins, C, Norris, S, McEntee, G, Traynor, O, Bruno, L, von Boehmer, H, Hegarty, J, O'Farrelly, C, RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation., European journal of immunology, 26, (12), 1996Journal Article, 1996, DOI
  • Srinivasan, U, Leonard, N, Jones, E, Kasarda, DD, Weir, DG, O'Farrelly, C, Feighery, C, Absence of oats toxicity in adult coeliac disease., BMJ (Clinical research ed.), 313, (7068), 1996, p1300-1Journal Article, 1996, URL , TARA - Full Text
  • Abuzakouk, M, Kelleher, D, Feighery, C, O'Farrelly, C, Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?, Gut, 39, (3), 1996, p396-400Journal Article, 1996, TARA - Full Text
  • Lynch, S, Kelleher, D, McManus, R, O'Farrelly, C, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation., European journal of immunology, 25, (5), 1995, p1143-7Journal Article, 1995, DOI , URL
  • Abuzakouk, M, Feighery, C, O'Farrelly, C, Collagenase and Dispase enzymes disrupt lymphocyte surface molecules., Journal of immunological methods, 194, (2), 1996, p211-6.Journal Article, 1996, DOI , URL
  • Kelleher, D, Murphy, A, Lynch, S, O'Farrelly, C, Adhesion molecules utilized in binding of intraepithelial lymphocytes to human enterocytes., European journal of immunology, 24, (4), 1994, p1013-6Journal Article, 1994, DOI , URL
  • Madrigal, L, Lynch, S, Feighery, C, Weir, D, Kelleher, D, O'Farrelly, C, Flow cytometric analysis of surface major histocompatibility complex class II expression on human epithelial cells prepared from small intestinal biopsies., Journal of immunological methods, 158, (2), 1993, p207-14Journal Article, 1993
  • O'Farrelly, C, Branton, D, Wanke, CA, Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain., Infection and immunity, 60, (7), 1992, p2593-7Journal Article, 1992, URL , TARA - Full Text
  • O'Farrelly, C, O'Mahony, C, Graeme-Cook, F, Feighery, C, McCartan, BE, Weir, DG, Gliadin antibodies identify gluten-sensitive oral ulceration in the absence of villous atrophy., Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 20, (10), 1991, p476-8Journal Article, 1991
  • O'Farrelly, C, Price, R, McGillivray, AJ, Fernandes, L, IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis., Immunological investigations, 18, (6), 1989, p753-64Journal Article, 1989
  • McCormick, PA, Feighery, C, Dolan, C, O'Farrelly, C, Kelliher, P, Graeme-Cook, F, Finch, A, Ward, K, Fitzgerald, MX, O'Donoghue, DP, Altered gastrointestinal immune response in sarcoidosis., Gut, 29, (12), 1988, p1628-31Journal Article, 1988, URL , TARA - Full Text
  • O'Farrelly, C, Marten, D, Melcher, D, McDougall, B, Price, R, Goldstein, AJ, Sherwood, R, Fernandes, L, Association between villous atrophy in rheumatoid arthritis and a rheumatoid factor and gliadin-specific IgG., Lancet, 2, (8615), 1988, p819-22Journal Article, 1988, URL
  • O'Farrelly, C, Graeme-Cook, F, Hourihane, DO, Feighery, C, Weir, DG, Histological changes associated with wheat protein antibodies in the absence of villous atrophy., Journal of Clinical Pathology, 40, (10), 1987, p1228-30Journal Article, 1987, URL , TARA - Full Text
  • Kelly, J, O'Farrelly, C, O'Mahony, C, Weir, DG, Feighery, C, Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel., Clinical and experimental immunology, 68, (1), 1987, p1228-30Journal Article, 1987, URL , TARA - Full Text
  • Mealy, K, O'Farrelly, C, Stephens, R, Feighery, C, Impaired neutrophil function during anesthesia and surgery is due to serum factors., The Journal of surgical research, 43, (5), 1987, p393-7Journal Article, 1987, URL
  • Kelly, J, O'Farrelly, C, Rees, JP, Feighery, C, Weir, DG, Humoral response to alpha gliadin as serological screening test for coeliac disease., Archives of disease in childhood, 62, (5), 1987, p469-73Journal Article, 1987, URL , TARA - Full Text
  • O'Farrelly, C, Feighery, C, O'Briain, DS, Stevens, F, Connolly, CE, McCarthy, C, Weir, DG, Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma., British medical journal (Clinical research ed.), 293, (6552), 1986, p908-10Journal Article, 1986, URL , TARA - Full Text
  • Watson, RG, McMillan, SA, Dolan, C, O'Farrelly, C, Cuthbert, RJ, Haire, M, Weir, DG, Porter, KG, Gliadin antibody detection in gluten enteropathy., The Ulster medical journal, 55, (2), 1986, p160-4Journal Article, 1986, URL , TARA - Full Text
  • O'Farrelly, C, Whelan, CA, Feighery, CF, Weir, DG, Suppressor-cell activity in coeliac disease induced by alpha-gliadin, a dietary antigen., Lancet, 2, (8415), 1984, p1305-7Journal Article, 1984, DOI
  • O'Farrelly, C, McKeever, U, Feighery, C, Weir, DG, Increased concanavalin A induced suppression in treated and untreated coeliac disease., Gut, 25, (6), 1984, p644-8Journal Article, 1984, URL , TARA - Full Text
  • O'Farrelly, C, Kelly, J, Hekkens, W, Bradley, B, Thompson, A, Feighery, C, Weir, DG, Alpha gliadin antibody levels: a serological test for coeliac disease., British medical journal (Clinical research ed.), 286, (6383), 1983, p2007-10Journal Article, 1983, URL , TARA - Full Text
  • O'Farrelly, C, Hekkens, WT, Feighery, C, Weir, DG, The specificity of wheat protein reactivity in coeliac disease., Scandinavian journal of gastroenterology, 18, (5), 1983, p603-7Journal Article, 1983
  • O'Farrelly, C, Feighery, C, Greally, JF, Weir, DG, Cellular response to alpha-gliadin in untreated coeliac disease., Gut, 23, (1), 1982, p83-7Journal Article, 1982, DOI , URL , TARA - Full Text
  • O'Farrelly, C, Immunoregulation in the liver and its extrahepatic relevance., Journal of pediatric gastroenterology and nutrition, 39 Suppl 3, 2004, pS727-S728Journal Article, 2004, URL
  • Lynn, DJ, Lloyd, AT, O'Farrelly, C, Bioinformatics: implications for medical research and clinical practice., Clinical and investigative medicine. Médecine clinique et experimentale, 26, (2), 2003, p70-4Journal Article, 2003
  • Golden-Mason, L, O'Farrelly, C, Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver., Immunology and cell biology, 80, (1), 2002, p45-51Journal Article, 2002, DOI , URL
  • O'Farrelly, C, Is villous atrophy always and only the result of gluten sensitive disease of the intestine?, European journal of Gastroenterology & Hepatology, 12, (6), 2000, p605-8Journal Article, 2000
  • D. Brady, N. Lowe, S. Gaines L. Fenelon, J. McPartlin, C. O'Farrelly, Inhibition of S. mutans growth by hen egg derived fatty acids., J Food Sci, 68, (4), 2003, p1433-1437Journal Article, 2003, DOI , URL
  • D. Brady, S. Gaines, L. Fenelon, J. Mc Partlin, C. O'Farrelly, A lipoprotein derived antimicrobial factor from hen egg yolk is active against Streptococcus species, J Food Sci , 67, (8), 2002, p3096-3103Journal Article, 2002, DOI , URL
  • T.Deignan, A. Alwan, L. Malone, J. Kelly, C. O'Farrelly. , Hen egg yolk prevents bacterial adherence: a novel function for a familiar food. , J Food Sci , 66, 2001, p158-161Journal Article, 2001, DOI , URL
  • T. Deignan, J. Kelly, A. Alwan, C. O'Farrelly. , Comparative analysis of methods of purification of egg yolk immunoglobin (IgY). , Food Agric Immunol, 12, 2000, p77-85Journal Article, 2000, URL
  • E. Healy, M. Leonard, L. Madrigal-Estebas, C. O'Farrelly, A. Watson, M. Ryan, Factors produced by activated leukocytes alter renal epithelial cell differentiation., Kidney International , 56, 1999, p1266-1269Journal Article, 1999, DOI , URL
  • A. Alwan, T. Deignan, M. O'Sullivan, J. Kelly, C. O'Farrelly, Quantitative assay of Salmonella adherence to intestinal epithelial cells: a new method for assessing novel intervention products., J Microbiological Methods, 33, (1), 1998, p163-170.Journal Article, 1998, DOI , URL
  • J. McDevitt, C. Feighery, C. O'Farrelly, G. Martin, D.G. Weir, D.K. Kelleher. , Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes., The Journal of Biological Chemistry, 4, 1995, p31-37Journal Article, 1995, DOI , TARA - Full Text
  • J. McDevitt, C. O'Farrelly, D.G. Weir, M. Bishr Omary, C. Feighery, D. Kelleher, Proliferation-associated marker in the coeliac duodenum, Eur J Gastroenterol Hepatol, 6, (3), 1994, p223-228Journal Article, 1994, URL
  • S. Lynch, D. Kelleher, C. Feighery, D. Weir, C. O'Farrelly, Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8 Ñ Ñ+cells., Eur J Gastroenterol Hepatol , 5, 1993, p907-912Journal Article, 1993, URL
  • Kieran G. Meade, Rowan Higgs, Andrew T. Lloyd, Seamus Giles and Cliona O'Farrelly, Differential antimicrobial peptide gene expression patterns during early chicken embryological development , Developmental & Comparative Immunology, 33, (4), 2009, p516-524Journal Article, 2009, DOI , URL , TARA - Full Text
  • Downing, T, Lynn, DJ, Connell, S, Lloyd, AT, Bhuiyan, AF, Silva, P, Naqvi, AN, Sanfo, R, Sow, RS, Podisi, B, O'Farrelly, C, Hanotte, O, Bradley, DG, Contrasting evolution of diversity at two disease-associated chicken genes., Immunogenetics, 61, (1), 2009, p303 - 314Journal Article, 2009, DOI
  • Higgs, R, Cormican, P, Cahalane, S, Allan, B, Lloyd, AT, Meade, K, James, T, Lynn, DJ, Babiuk, LA, O'farrelly, C, Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection., Infection and immunity, 74, (3), 2006, p1692-Journal Article, 2006, DOI , TARA - Full Text
  • Ronan G. Shaughnessy, Kieran G. Meade, Sarah Cahalane, Brenda Allan, Carla Reiman, John J. Callanan and Cliona O' Farrelly, Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter, Veterinary Immunology and Immunopathology, 132, (2-4), 2009, p191-198Journal Article, 2009, DOI , TARA - Full Text
  • Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610Journal Article, 2009, DOI , URL , TARA - Full Text
  • Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901Journal Article, 2009, DOI
  • Dunne J, Lynch S, O'Farrelly C, Hegarty JE, Feighery C, Doherty DG., Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. , Journal of Immunology, 167, (6), 2001, p3129-3138Journal Article, 2001, URL
  • Doherty, D.G., O'Farrelly, C., Dendritic cells: Regulators of hepatic immunity or tolerance?, Journal of Hepatology, 34, (1), 2001, p156-160Journal Article, 2001, DOI
  • Doherty, D.G., O'Farrelly, C., Innate and adaptive lymphoid cells in the human liver , Immunological Reviews, 174, (1), 2000, p5-20Review Article, 2000, DOI
  • Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT, Evidence of the adaptive evolution of immune genes in chicken, BMC Research Notes, 2, (254), 2009, part. no. 254Journal Article, 2009, DOI , URL , TARA - Full Text
  • Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, O'Farrelly C, Bradley DG, Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus., BMC Evolutionary Biology, 9, 2009, part. no. 136Journal Article, 2009, DOI , URL , TARA - Full Text
  • Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty and Cliona O'Farrelly, A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832Journal Article, 2010, DOI , URL , TARA - Full Text
  • Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474Journal Article, 2010, DOI , URL , TARA - Full Text
  • Cormac J. Whelehan, Kieran G. Meade, P. David Eckersall, Fiona J. Young, Cliona O'Farrelly, EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION, Veterinary Immunology and Immunopathology, 140, (3-4), 2011, p181-189Journal Article, 2011, DOI , URL , TARA - Full Text
  • O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418Journal Article, 2010, DOI
  • Smith, KJ, Norris, S, O'Dwyer, AM & O'Mara, SM. , Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha., Neuropsychiatric Disease and Treatment, 2010, p1-18Journal Article, 2010, TARA - Full Text
  • Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207Journal Article, 2011, DOI , URL , TARA - Full Text
  • Ronan G. Shaughnessy, Kieran G. Meade, Beatrice A. McGivney, Brenda Allan, Cliona O' Farrelly, Global gene expression analysis of chicken caecal response to Campylobacter jejuni, Veterinary Immunology and Immunopathology, 142, (1-2), 2011, p64-71Journal Article, 2011, DOI , URL , TARA - Full Text
  • Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R, O'Farrelly C, Gardiner CM, Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection., PNAS, 108, (14), 2011, p5736-41Journal Article, 2011, DOI , TARA - Full Text
  • Kevin P. Kennelly, Deborah M. Wallace, Toby M. Holmes, Deborah J. Hankey, Timothy S. Grant, Cliona O'Farrelly, David J. Keegan , Preparation of Pre-Confluent Retinal Cells Increases Graft Viability In Vitro and In Vivo: A Mouse Model, PLoS One, 6, (6, e21365), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Narciandi F, Lloyd AT, Chapwanya A, O' Farrelly C, Meade KG, Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine ß-defensin cluster., Immunogenetics, 63, (10), 2011, p641-651Journal Article, 2011, DOI
  • Downing T, Lloyd AT, O'Farrelly C, Bradley DG, The differential evolutionary dynamics of avian cytokine and TLR gene classes., Journal of immunology (Baltimore, Md. : 1950), 184, (12), 2010, p6993-7000Journal Article, 2010, DOI
  • Cormican P, Lloyd AT, Downing T, Connell SJ, Bradley D, O'Farrelly C, The avian Toll-Like receptor pathway--subtle differences amidst general conformity., Developmental and comparative immunology, 33, (9), 2009, p967-73Journal Article, 2009, DOI
  • Petrovic D., Stamataki Z., Dempsey E., Golden-Mason L., Freeley M., Doherty D., Prichard D., Keogh C., Conroy J., Mitchell S., Volkov Y., McKeating J.A., O'Farrelly C., Kelleher D., Long A., Hepatitis C virus targets the Tcell secretory machinery as a mechanism of immune evasion, Hepatology, 53, (6), 2011, p1846 - 1853Journal Article, 2011, DOI , URL
  • Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866Journal Article, 2011, DOI , URL , TARA - Full Text
  • Ceara E. Walsh, Elizabeth J. Ryan, Cliona O'Farrelly, Lucy Golden-Mason, Oliver FitzGerald, Douglas J. Veale, Barry Bresnihan, Ursula Fearon, Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease, PLoS One, 6, (11, e27182), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Kate E Killick, John A Browne, Stephen DE Park, David A Magee, Irene Martin, Kieran G Meade, Stephen V Gordon, Eamonn Gormley, Cliona O'Farrelly, Karsten Hokamp and David E MacHugh, Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes, BMC Genomics , 12, (611), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
  • Lawler M, Humphries P, O'Farrelly C, Hoey H, Sheils O, Jeffers M, O'Briain DS, Kelleher D., Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum., Gut. , 35, (9), 1994, p1226-1232Journal Article, 1994, DOI , TARA - Full Text
  • Connell S, Meade KG, Allan B, Lloyd AT, Kenny E, Cormican P, Morris DW, Bradley DG, O'Farrelly C, Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing., PloS one, 7, (8), 2012, pe40409Journal Article, 2012, DOI , TARA - Full Text
  • Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG, Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows., BMC genomics, 13, (1), 2012, p489Journal Article, 2012, DOI , TARA - Full Text
  • Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578Journal Article, 2013, DOI , TARA - Full Text
  • Downing, T., O'Farrelly, C., Bhuiyan, A.K., Silva, P., Naqvi, A.N., Sanfo, R., Sow, R.-S., (...), Bradley, D.G.., Variation in chicken populations may affect the enzymatic activity of lysozyme, Animal Genetics, 41, (2), 2010, p213-217Journal Article, 2010, DOI
  • Downing, T., Lynn, D.J., Connell, S., Lloyd, A.T., Bhuiyan, A.K.F.H., Silva, P., Naqvi, A.N., (...), Bradley, D.G. , Erratum: Contrasting evolution of diversity at two disease-associated chicken genes (Immunogenetics DOI: 10.1007/s00251-009-0359-x), 2009, - 421-422Miscellaneous, 2009
  • Doherty, R., O'Farrelly, C., Meade, K.G., Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC), Veterinary Immunology and Immunopathology, 154, (3-4), 2013, p102-110Journal Article, 2013, DOI
  • O'Donovan, A., Rush, G., Hoatam, G., Hughes, B.M., McCrohan, A., Kelleher, C., O'Farrelly, C., Malone, K.M., Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder, Depression and Anxiety , 30, (4), 2013, p307-314Journal Article, 2013, DOI
  • Lawless, N., Foroushani, A.B.K., McCabe, M.S., O'Farrelly, C., Lynn, D.J., Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection, PLoS ONE, 8, (3), 2013, part. no. e57543Journal Article, 2013, DOI , TARA - Full Text
  • Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. coli stimulation, Veterinary Immunology and Immunopathology , 151, (1-2), 2013, p157-162Journal Article, 2013, DOI
  • Klintmalm, G., O'Farrelly, C., Taking the rap: Multiple effects of blocking mammalian target of rapamycin, Hepatology, 57, (1), 2013, p1-3Journal Article, 2013, DOI
  • Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ, Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection., Cytokine, 60, (2), 2012, p328-33Journal Article, 2012, DOI
  • Chapwanya A, Meade KG, Foley C, Narciandi F, Evans AC, Doherty ML, Callanan JJ, O'Farrelly C, The postpartum endometrial inflammatory response: a normal physiological event with potential implications for bovine fertility., Reproduction, fertility, and development, 24, (8), 2012, p1028-1039Journal Article, 2012, DOI
  • Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87Journal Article, 2012, DOI , TARA - Full Text
  • McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C, Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells., Reproductive biomedicine online, 25, (3), 2012, p322-328Journal Article, 2012, DOI
  • Sarwar S, Ryan EJ, Iqbal M, McCormick PA, O'Farrelly C, Hegarty J, Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection., Irish journal of medical science, 181, (1), 2012, p53-58Journal Article, 2012, DOI
  • Meade KG, O'Gorman GM, Narciandi F, Machugh DE, O'Farrelly C, Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro., Molecular immunology, 50, (1-2), 2012, p108-116Journal Article, 2012, DOI
  • Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16Journal Article, 2012, DOI
  • Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851Journal Article, 2011, DOI , TARA - Full Text
  • Ryan, E.J., O'Farrelly, C., The affect of chronic hepatitis C infection on dendritic cell function: A summary of the experimental evidence, Journal of Viral Hepatitis, 18, (9), 2011, p601-607Journal Article, 2011, DOI
  • Tobin, A.M., Lynch, L., Kirby, B., O'Farrelly, C., Natural killer cells in psoriasis, Journal of Innate Immunity , 3, (4), 2011, 403-410Journal Article, 2011, DOI
  • Foley, C., O'Farrelly, C., Meade, K.G, Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods, Journal of Dairy Science, 94, (6), 2011, p3159-3165dsJournal Article, 2011, DOI
  • Tajuddin, T., Ryan, E.J., Norris, S., Hegarty, J.E., O'Farrelly, C., Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist, Journal of Gastroenterology and Hepatology, 25, (12), 2010, p1883-1890Journal Article, 2010, DOI
  • O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077Journal Article, 2010, DOI , TARA - Full Text
  • O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997Journal Article, 2010, DOI , TARA - Full Text
  • O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660Journal Article, 2010, DOI , TARA - Full Text
  • Chapwanya, A., Meade, K.G., Narciandi, F., Stanley, P., Mee, J.F., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial biopsy: a valuable clinical and research tool in bovine reproduction, Theriogenology, 73, (7), 2010, p988-994Journal Article, 2010, DOI
  • Meade, K.G., O'Gorman, G.M., Hill, E.W., Narciandi, F., Agaba, M., Kemp, S.J., O'Farrelly, C., MacHugh, D.E., Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle, Molecular Immunology, 47, (2-3), 2009, p196-204Journal Article, 2009, DOI
  • O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045Journal Article, 2009, DOI
  • Nemeth, E., Baird, A.W., O'Farrelly, C., Microanatomy of the liver immune system, Seminars in Immunopathology, 31, (3), 2009, p333-343Journal Article, 2009, DOI
  • MacHugh, D.E., Gormley, E., Park, S.D.E., Browne, J.A., Taraktsoglou, M., O'Farrelly, C., Meade, K.G., Gene expression profiling of the host response to mycobacterium bovis infection in cattle, Transboundary and Emerging Diseases , 56, (6-7), 2009, p204-214Journal Article, 2009, DOI
  • Nanda, K.S., Ryan, E.J., Murray, B.F., Brady, J.J., McKenna, M.J., Nolan, N., O'Farrelly, C., Hegarty, J.E., Effect of Chronic Hepatitis C Virus Infection on Bone Disease in Postmenopausal Women, Clinical Gastroenterology and Hepatology, 7, (8), 2009, p894-899Journal Article, 2009, DOI
  • Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, John.J., Mee, J.F., O'Farrelly, C, Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: Toward an improved understanding of uterine innate immunity, Theriogenology, 71, (9), 2009, p1396-1407Journal Article, 2009, DOI
  • Mcgrath, E., Ryan, E.J., Lynch, L., Golden-Mason, L., Mooney, E., Eogan, M., O'herlihy, C., O'Farrelly, C., Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility, American Journal of Reproductive Immunology, 61, (4), 2009, p265-276Journal Article, 2009, DOI
  • Lynch, L.A., O'Connell, J.M., Kwasnik, A.K., Cawood, T.J., O'Farrelly, C., O'Shea, D.B., Are natural killer cells protecting the metabolically healthy obese patient?, Obesity, 17, (3), 2009, p601-605Journal Article, 2009, DOI
  • Meade, K.G., Narciandi, F., Cahalane, S., Reiman, C., Allan, B., O'Farrelly, C., Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens, Immunogenetics, 61, (2), 2009, p101-110Journal Article, 2009, DOI
  • Narciandi F, Lloyd A, Meade KG, O'Farrelly C, A novel subclass of bovine ?-defensins links reproduction and immunology., Reproduction, fertility, and development, 2013Journal Article, 2013
  • Kelly, Aoife Ryan, Elizabeth J. O'Farrelly, Cliona, Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems", Journal of Hepatology, 60, (5), 2014, p1098-1099Journal Article, 2014, TARA - Full Text
  • Kelly, A., Fahey, R., Fletcher, J.M., Keogh, C., Carroll, A.G., Siddachari, R., Geoghegan, J., Hegarty, J.E., Ryan, E.J., O'Farrelly, C., CD141+ myeloid dendritic cells are enriched in healthy human liver, Journal of Hepatology, 60, (1), 2014, p135-142Journal Article, 2014, DOI
  • Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832Journal Article, 2010, DOI , TARA - Full Text
  • Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63Journal Article, 2014, DOI , TARA - Full Text
  • Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090Journal Article, 2013, DOI , TARA - Full Text
  • Lawless N, Foroushani AB, McCabe MS, O'Farrelly C, Lynn DJ, Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection., PloS one, 8, (3), 2013, pe57543Journal Article, 2013, DOI , TARA - Full Text
  • Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, (7), 2013, pe69090Journal Article, 2013, DOI , TARA - Full Text
  • Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050Journal Article, 2014, DOI , TARA - Full Text
  • Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-Journal Article, 2014, DOI , TARA - Full Text
  • Connell, S, Meade, KG, Allan, B, Lloyd, AT, Downing, T, O'Farrelly, C, Bradley, DG, Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene, G3-GENES GENOMES GENETICS, 3, (5), 2013, p881-890Journal Article, 2013, DOI , TARA - Full Text
  • Morrison, M.H., Keane, C., Quinn, L.M., (...), Bergin, C., Gardiner, C.M., IFNL cytokines do not modulate human or murine NK cell functions, Human Immunology, 75, (9), 2014, p996-1000Journal Article, 2014, DOI , TARA - Full Text
  • Whelehan, CJ, Barry-Reidy, A, Meade, KG, Eckersall, PD, Chapwanya, A, Narciandi, F, Lloyd, AT, O'Farrelly, C, Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue, BMC GENOMICS, 15, 2014, p128-Journal Article, 2014, DOI , TARA - Full Text
  • Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050Journal Article, 2014, DOI , TARA - Full Text
  • Lawless, N., Reinhardt, T.A., Bryan, K., (...), Lippolis, J., Lynn, D.J., Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model, G3: Genes, Genomes, Genetics, 4, (6), 2014, p957-971Journal Article, 2014, DOI , TARA - Full Text
  • Kelly, A, Fahey, R, Fletcher, JM, Keogh, C, Carroll, AG, Siddachari, R, Geoghegan, J, Hegarty, JE, Ryan, EJ, O'Farrelly, C, CD141(+) myeloid dendritic cells are enriched in healthy human liver, JOURNAL OF HEPATOLOGY, 60, (1), 2014, p135-142Journal Article, 2014, DOI
  • Meade, K.G., Cormican, P., Narciandi, F., Lloyd, A., O'Farrelly, C., Bovine β-defensin gene family: Opportunities to improve animal health?, Physiological Genomics, 46, (1), 2014, p17-28Journal Article, 2014, DOI , TARA - Full Text
  • Killick, K.E., Ní Cheallaigh, C., O'Farrelly, C., (...), Machugh, D.E., Harris, J., Receptor-mediated recognition of mycobacterial pathogens, Cellular Microbiology, 15, (9), 2013, p1484-1495Journal Article, 2013, DOI
  • McLoughlin KE, Nalpas NC, Rue-Albrecht K, Browne JA, Magee DA, Killick KE, Park SD, Hokamp K, Meade KG, O'Farrelly C, Gormley E, Gordon SV, MacHugh DE, RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis., Frontiers in immunology, 5, 2014, p396Journal Article, 2014, DOI , TARA - Full Text
  • Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744Journal Article, DOI
  • Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenso, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744Journal Article, DOI , TARA - Full Text
  • Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ]Book Chapter
  • A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ]Book Chapter
  • Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.]Book Chapter

Research Expertise

  • Title
    Liver Trust S.V.U.H.
    Summary
    Identification and characterisation of hepatic features prognostic of disease progress in transplant rejection and Hepatitis C
    Date From
    2004
  • Title
    H.R.B. (Fellowship)
    Summary
    Human GI epithelial cells and their role in extrathymic T lymphocyte differentiation
    Funding Agency
    HRB
    Date From
    1991
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    Antigen presentation by normal and coeliac small intestinal epithelial cells
    Funding Agency
    HRB
    Date From
    1990
  • Title
    HRB (Grant in aid) 1998
    Summary
    T Lymphocyte differentiation in adult human liver (with Dr. J. Hegarty)
    Funding Agency
    HRB
    Date From
    1998
  • Title
    Dept. Agriculture Functional Foods Programme
    Summary
    Novel Antibacterial factors from Hen Eggs
    Funding Agency
    Dept. Agriculture Functional Foods Programme
    Date From
    1997
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    Phenotype and functional analysis of intraepithelial lymphocytes from coeliac small intestinal biopsies
    Funding Agency
    HRB
    Date From
    1991
  • Title
    Dept. Agriculture Research Stimulus Fund 2006 06/340
    Summary
    Structural and functional identification of candidate immune genes for resistance to mastitis and metritis
    Funding Agency
    Dept. Agriculture
    Date From
    2006
  • Title
    HRB Project Grant 2007 RP/2007/278
    Summary
    Suppressor of Cytokine Signalling (SOCS) Protein Involvement in Chronic Hepatitis C Virus (HCV) Infection and Failure to Respond to Interferon Alpha Therapy
    Funding Agency
    HRB
    Date From
    2007
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    The liver as a site of extrathymic T cell differentiation
    Funding Agency
    HRB
    Date From
    1994
  • Title
    HRB Research Project Grants General 2001RP141/2001
    Summary
    Adult Stem Cells: Development of T Cells in the Human Intestine
    Funding Agency
    HRB
    Date From
    2001
  • Title
    FORBAIRT Basic Grant
    Summary
    Unconventional T lymphocytes in the intestine
    Funding Agency
    FORBAIRT
    Date From
    1996
  • Title
    EOLAS/British Council Research
    Summary
    EOLAS/British Council Research Exchange Scheme (with Dr. P. Bland) 1993
    Funding Agency
    EOLAS/British Council Research
    Date From
    1993
  • Title
    EOLAS Higher Education Industry Co-operation grant 1994
    Summary
    EOLAS Higher Education Industry Co-operation grant 1994: Passive immunisation of pigs against scour (with Dr. J. Kelly)
    Funding Agency
    EOLAS Higher Education Industry Co-operation
    Date From
    1994
  • Title
    H.R.B. (Grant-in-aid) 1995
    Summary
    Cytokine Elaboration by Intestinal Epithelial Cells
    Funding Agency
    HRB
    Date From
    1995
  • Title
    Enterprise Ireland Grant 1999 ST/1999/150
    Summary
    Characterisation of novel antimicrobial proteins for inclusion in oral healthcare products (with Mr. M. Folan)
    Funding Agency
    Enterprise Ireland
    Date From
    1999
  • Title
    Enterprise Ireland Proof of Concept phase Winter Call 2005 PC/2005/242
    Summary
    Evolution based approaches to directed alteration of AMPs for improved efficacy against Propionibacterium acnes and MRSA
    Funding Agency
    Enterprise Ireland
    Date From
    2005
  • Title
    The Arthritis Foundation of Ireland,
    Summary
    Dietary Antigens and the Gut in Rheumatoid Arthritis
    Funding Agency
    The Arthritis Foundation of Ireland,
    Date From
    1990
  • Title
    HRB Research Project Grants - General 2005 RP/2005/217
    Summary
    (with Dr. Clair Gardiner, T.C.D. & HCV Research Consortium) Investigation of KIR genotype in the resolution of HCV infection
    Date From
    2005
  • Title
    Enterprise Ireland Grant 1999 SC/1999/345
    Summary
    The effect of intestinal epithelial microenvironment on T cell activation (with Dr. D. O'Donoghue)
    Date From
    1999
  • Title
    D.I.T. Strategic Research and Development Grant
    Summary
    (with Dr. J. Kelly): Passive oral immunisation of pigs against scour using specific egg immunoglobulin
    Funding Agency
    DIT
    Date From
    1992
  • Title
    HRB Research Programme Grant 2003 BPRO/02/2003
    Summary
    Characterisation Hepatitis C Induced Immunological Subversion and its Implications for Treatment Response
    Funding Agency
    HRB
    Date From
    2003
  • Title
    SFI Research Frontiers Programme 2005 05/RFP/BIC0012
    Summary
    Role of CD1d isoforms and reactive cells in regulating immune responses to malignancy
    Funding Agency
    SFI
    Date From
    2005
  • Title
    SFI Research Frontiers 2008 08/RFP/BMT1403
    Summary
    The role of Hepatitis C Virus in regulating Signal Transducer and Activator of Transcription (STAT) protein expression to evade anti-viral Interferon-á responses.
    Funding Agency
    SFI
    Date From
    2008
  • Title
    Enterprise Ireland Basic Research Grant Programme 2003 SC/2003/567
    Summary
    Cytokine Milieu, Natural Killer Receptor Positive Cells, Haematopoietic Progenitors in Human Endometrium
    Funding Agency
    Enterprise Ireland
    Date From
    2003
  • Title
    FIRM Grant 2006 06/RDD/486
    Summary
    Identification of genes responsible for natural host resistance to Campylobacter colonisation tools to identify and breed genetically resistant chickens
    Funding Agency
    FIRM Grant
    Date From
    2006
  • Title
    HRB Translational Research Award 2007 TRA/2007/14
    Summary
    (with Dr. Aideen Long TCD & Prof. Dermot Kelleher, TCD) Immune targeting strategies: improving the response rate to IFN-alpha/ribavirin therapy in chronic Hepatitis C Virus infection
    Funding Agency
    HRB
    Date From
    2007
  • Title
    HRB (Project Grant) 1999 165/99
    Summary
    Streptococcus Mutans adherence to hydroxyapatite beads and its prevention (with Dr. L. Fenelon)
    Funding Agency
    HRB
    Date To
    1999
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    T cell populations in the human uterus (with Prof. C.O'Herlihy)
    Funding Agency
    HRB
    Date From
    1996
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    Prevention of C.difficile infection with egg (with Dr. L. Fenelon)
    Funding Agency
    HRB
    Date From
    1997
  • Title
    FIRM Programme Grant 200101/R&D/D/135
    Summary
    Antimicrobial activity in Hen Eggs, a Combined Bioinformatic, Biochemical and Molecular Biological Approach
    Funding Agency
    FIRM
    Date From
    2001
  • Title
    FORBAIRT Strategic Development Award
    Summary
    Prevention of neonatal scour using probiotic bacteria and hen egg antibodies (with Dr. M.O'Sullivan)
    Funding Agency
    FORBAIRT
    Date From
    1994
  • Title
    HRB Project Grant 2000 RP86/2000
    Summary
    Quantification of Hepatitis C Viral load in lymphocyte subpopulations (with John Hegarty)
    Funding Agency
    HRB
    Date From
    2000
  • Title
    Enterprise Ireland/British Council 2000: (for promoting collaboration):
    Summary
    Adult Stem Cells in Human Liver (with Prof. A. Strain, Birmingham University)
    Funding Agency
    Enterprise Ireland/British Council
    Date From
    2000
  • Title
    FIRM Grant 2004 04/R&D/D/295
    Summary
    Functional immunogenomics in the chicken: relevance to avian influenza virus infection
    Funding Agency
    FIRM
    Date From
    2004
  • Title
    Irish Cancer Society Grant 1999 CRAB 1999/2000
    Summary
    Natural T cells in human bone marrow and their role in haematopoietic malignancy (with Dr. D. McCarthy)
    Funding Agency
    Irish Cancer Society
    Date From
    1999
  • Title
    H.R.B. (Grant-in-aid)
    Summary
    The gastrointestinal tract: a site of extrathymic T cell differentiation
    Date From
    1993

Recognition

  • Grave's Lecturer and Medallist 1997
  • Irish Research Scientists Association Gold Medal 1998
  • Isla Haliday Memorial Lecture 2004
  • Thomas Davis Lecturer 1999
  • Conway Lecturer and Medallist 2004
  • President, Irish Society of Immunology 2001-2007
  • Irish Society Immunology Public Lecture Award 2008
  • Fellow Royal Academy of Medicine of Ireland 1997
  • Irish Society of Immunology present