Professor Kingston Mills

• Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50Journal Article, 2015, DOI , TARA - Full Text
• Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257Journal Article, 2015, DOI , URL
• McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560Journal Article, 2015, DOI , URL
• Edwards S.C, Higgins S.C, Mills K.H.G, Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction, Brain, Behavior, and Immunity, 50, 2015, p41 - 46Journal Article, 2015, DOI , URL , TARA - Full Text
• Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM, Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity., Journal of immunology (Baltimore, Md. : 1950), 195, (2), 2015, p528-40Journal Article, 2015, DOI
• Brummelman J, Wilk MM, Han WG, van Els CA, Mills KH, Roads to the development of improved pertussis vaccines paved by immunology., Pathogens and disease, 73, (8), 2015, pftv067Journal Article, 2015, DOI , TARA - Full Text
• Edwards SC, McGinley AM, McGuinness NC, Mills KH, γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity., Frontiers in immunology, 6, 2015, p455Journal Article, 2015, DOI , TARA - Full Text
• Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714Journal Article, 2016, DOI
• Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60Journal Article, 2015, DOI , TARA - Full Text
• K.H.G. Mills, Regulatory T cells: friend or foe in immunity to infection. , Nature Reviews Immunology, 4, 2004, p841 - 855Journal Article, 2004, DOI , TARA - Full Text
• Raverdeau M, Breen C.J, Misiak A, Mills K.H.G, Retinoic acid suppresses IL-17 production and pathogenic activity of γΎ T cells in CNS autoimmunity, Immunology and Cell Biology, 94, (8), 2016, p763 - 773Journal Article, 2016, DOI , URL
• Lee J.P.W, Foote A, Fan H, Peral de Castro C, Lang T, Jones S.A, Gavrilescu N, Mills K.H.G, Leech M, Morand E.F, Harris J, Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages, Autophagy, 12, (6), 2016, p907 - 916Journal Article, 2016, DOI , URL
• Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427-Journal Article, 2016, DOI , URL
• Gardiner C.M, Mills K.H.G, The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases, Seminars in Immunology, 28, (4), 2016, p343-350Journal Article, 2016, DOI
• Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679Journal Article, 2015, DOI , URL
• Edwards S.C, McGinley A.M, McGuinness N.C, Mills K.H.G, γÎ" T cells and NK cells - distinct pathogenic roles as innate-like immune cells in CNS autoimmunity, Frontiers in Immunology, 6, (SEP), 2015, p1-Journal Article, 2015, DOI , URL
• Murphy A.G, O'Keeffe K.M, Lalor S.J, Maher B.M, Mills K.H.G, McLoughlin R.M, Staphylococcus aureus infection of mice expands a population of memory γΎ T cells that are protective against subsequent infection (Journal of Immunology (2014) 192 (3697-3708)), Journal of Immunology, 194, (9), 2015, p4588-Journal Article, 2015, DOI , URL
• Lavelle, E.C., McGuirk, P. and Mills, K.H.G. , Molecules of Infectious Agents as Immunomodulatory Drugs, Current Medicinal Chemistry , 4, (5), 2004, p499 - 508Journal Article, 2004, URL
• Saadatian-Elahi M, Plotkin S, Mills K.H.G, Halperin S.A, McIntyre P.B, Picot V, Louis J, Johnson D.R, Pertussis: Biology, epidemiology and prevention, Vaccine, 34, (48), 2016, p5819 - 5826Journal Article, 2016, DOI , URL
• Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441Journal Article, 2016, DOI , URL , TARA - Full Text
• Dyck L, Wilk M.M, Raverdeau M, Misiak A, Boon L, Mills K.H.G, Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model, Cancer Immunol Immunother , 65, 2016, p1491-Journal Article, 2016, DOI , URL
• Misiak A, Wilk M.M, Raverdeau M, Mills K.H.G, IL-17-producing innate and pathogen-specific tissue resident memory γΎ T cells expand in the lungs of Bordetella pertussis-infected mice, Journal of Immunology, 198, (1), 2017, p363 - 374Journal Article, 2017, DOI , URL
• Exley M.A, Tsokos G.C, Mills K.H.G, Elewaut D, Mulhearn B, What rheumatologists need to know about innate lymphocytes, Nature Reviews Rheumatology, 12, (11), 2016, 2016 Nov;12(11):658-668. doi:Journal Article, 2016, DOI , URL
• Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039Journal Article, 2017, DOI
• Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina , Glycerol-induced seizure: Involvement of IL-1[beta] and glutamate, NEUROREPORT, 10, (9), 1999, p1821 - 1825Journal Article, 1999, URL
• Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, and Marina A. Lynch, Interleukin-1â-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine , Journal of Neuroimmunology, 111, (1-2), 2000, p68 - 76Journal Article, 2000, DOI , URL
• Dyck, L., Mills, K.H.G. , Immune checkpoints and their inhibition in cancer and infectious diseases, European Journal of Immunology, 47, (5), 2017, p765-779Journal Article, 2017, DOI
• Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH., Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine., Annals of the New York Academy of Sciences, 856, 1998, p274 - 277Journal Article, 1998, URL
• Sheila Donnelly, Christine E. Loscher, Marina A. Lynch, and Kingston H. G. Mills, Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination, Infection and Immunity, 69, (7), 2001, p4217 - 4223Journal Article, 2001, DOI , TARA - Full Text
• Nascimento, I.P., Rodriguez, D., Santos, C.C., (...), Rappuoli, R., Leite, L.C.C. , Recombinant BCG expressing LTAK63 adjuvant induces superior protection against Mycobacterium tuberculosis , Scientific Reports, 7, (1), 2017, p2109Journal Article, 2017, DOI , TARA - Full Text
• Gu, X.-X., Plotkin, S.A., Edwards, K.M., (...), Lu, K.T., Taylor, C.E. , Waning immunity and microbial vaccines-workshop of the National Institute of Allergy and infectious diseases, Clinical and Vaccine Immunology, 24, (7), 2017, pe00034-17Journal Article, 2017, DOI
• McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12Journal Article, 2017, DOI
• Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243Journal Article, 2017, DOI
• Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923-Journal Article, 2017, DOI , URL , TARA - Full Text
• Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017Journal Article, 2017, DOI , URL
• Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 -Journal Article, 2017, DOI , URL
• Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Akdis, M. and AndrÀ, I. and Annunziato, F. and Bacher, P. and Barnaba, V. and Battistini, L. and Bauer, W.M. and Baumgart, S. and Becher, B. and Beisker, W. and Berek, C. and Blanco, A. and Borsellino, G. and Boulais, P.E. and Brinkman, R.R. and BÃŒscher, M. and Busch, D.H. and Bushnell, T.P. and Cao, X. and Cavani, A. and Chattopadhyay, P.K. and Cheng, Q. and Chow, S. and Clerici, M. and Cooke, A. and Cosma, A. and Cosmi, L. and Cumano, A. and Dang, V.D. and Davies, D. and De Biasi, S. and Del Zotto, G. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Diefenbach, A. and Di Santo, J. and Dieli, F. and Dolf, A. and Donnenberg, V.S. and Dörner, T. and Ehrhardt, G.R.A. and Endl, E. and Engel, P. and Engelhardt, B. and Esser, C. and Everts, B. and Dreher, A. and Falk, C.S. and Fehniger, T.A. and Filby, A. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frenette, P.S. and Galbraith, D. and Garbi, N. and García-Godoy, M.D. and Geginat, J. and Ghoreschi, K. and Gibellini, L. and Goettlinger, C. and Goodyear, C.S. and Gori, A. and Grogan, J. and Gross, M. and GrÃŒtzkau, A. and Grummitt, D. and Hahn, J. and Hammer, Q. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Herrera, G. and Herrmann, M. and Hiepe, F. and Holland, T. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Hunter, C.A. and Iannone, A. and JÀck, H.-M. and Jávega, B. and Jonjic, S. and Juelke, K. and Jung, S. and Kaiser, T. and Kalina, T. and Keller, B. and Khan, S. and Kienhöfer, D. and Kroneis, T. and Kunkel, D. and Kurts, C. and Kvistborg, P. and Lannigan, J. and Lantz, O. and Larbi, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Levings, M.K. and Litwin, V. and Liu, Y. and Lohoff, M. and Lombardi, G. and Lopez, L. and Lovett-Racke, A. and Lubberts, E. and Ludewig, B. and Lugli, E. and Maecker, H.T. and Martrus, G. and Matarese, G. and Maueröder, C. and McGrath, M. and McInnes, I. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Mills, K. and Mirrer, D. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, A. and Moretta, L. and Mosmann, T.R. and MÃŒller, S. and MÃŒller, W. and MÃŒnz, C. and Multhoff, G. and Munoz, L.E. and Murphy, K.M. and Nakayama, T. and Nasi, M. and Neudörfl, C. and Nolan, J. and Nourshargh, S. and O'Connor, J.-E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Peterson, P. and Peth, C. and Petriz, J. and Philips, D. and Pickl, W. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Pucillo, C. and Quataert, S.A. and Radstake, T.R.D.J. and Rajwa, B. and Rebhahn, J.A. and Recktenwald, D. and Remmerswaal, E.B.M. and Rezvani, K. and Rico, L.G. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruckert, B. and Ruland, J. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sawitzki, B. and Scheffold, A. and Schiemann, M. and Schildberg, F. and Schimisky, E. and Schmid, S.A. and Schmitt, S. and Schober, K. and SchÃŒler, T. and Schulz, A.R. and Schumacher, T. and Scotta, C. and Shankey, T.V. and Shemer, A. and Simon, A.-K. and Spidlen, J. and Stall, A.M. and Stark, R. and Stehle, Guidelines for the use of flow cytometry and cell sorting in immunological studies, European Journal of Immunology, 47, (10), 2017, p1584-1797Journal Article, 2017, DOI , URL
• Misiak, A. and Leuzzi, R. and Allen, A.C. and Galletti, B. and Baudner, B.C. and D'Oro, U. and O'Hagan, D.T. and Pizza, M. and Seubert, A. and Mills, K.H.G., Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model, Vaccine, 35, (39), 2017, p5256-5263Journal Article, 2017, DOI , URL , TARA - Full Text
• Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831Journal Article, 2017, DOI , URL
• McGinley, A.M. and Edwards, S.C. and Raverdeau, M. and Mills, K.H.G., Th17 cells, γΎ T cells and their interplay in EAE and multiple sclerosis, Journal of Autoimmunity, 87, 2018, p16-25Journal Article, 2018, DOI , URL
• Fuchs, A. and Gliwinski, M. and Grageda, N. and Spiering, R. and Abbas, A.K. and Appel, S. and Bacchetta, R. and Battaglia, M. and Berglund, D. and Blazar, B. and Bluestone, J.A. and BornhÃ"user, M. and Brinke, A. and Brusko, T.M. and Cools, N. and Cuturi, M.C. and Geissler, E. and Giannoukakis, N. and Golab, K. and Hafler, D.A. and van Ham, S.M. and Hester, J. and Hippen, K. and Di Ianni, M. and Ilic, N. and Isaacs, J. and Issa, F. and Iwaszkiewicz-Grzes, D. and Jaeckel, E. and Joosten, I. and Klatzmann, D. and Koenen, H. and Kooten, C. and Korsgren, O. and Kretschmer, K. and Levings, M. and Marek-Trzonkowska, N.M. and Martinez-Llordella, M. and Miljkovic, D. and Mills, K.H.G. and Miranda, J.P. and Piccirillo, C.A. and Putnam, A.L. and Ritter, T. and Roncarolo, M.G. and Sakaguchi, S. and Sánchez-Ramón, S. and Sawitzki, B. and Sofronic-Milosavljevic, L. and Sykes, M. and Tang, Q. and Vives-Pi, M. and Waldmann, H. and Witkowski, P. and Wood, K.J. and Gregori, S. and Hilkens, C.M.U. and Lombardi, G. and Lord, P. and Martinez-Caceres, E.M. and Trzonkowski, P., Minimum information about T regulatory cells: A step toward reproducibility and standardization, Frontiers in Immunology, 8, (JAN), 2018, p01844-Journal Article, 2018, DOI , URL , TARA - Full Text
• Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674Journal Article, 2019, DOI , TARA - Full Text
• Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and O†Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and O†Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340Journal Article, 2018, DOI , URL
• Allen, A.C. and Wilk, M.M. and Misiak, A. and Borkner, L. and Murphy, D. and Mills, K.H.G., Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells, Mucosal Immunology, 11, (6), 2018, p1763-1776Journal Article, 2018, DOI , URL
• Solans, L. and Debrie, A.-S. and Borkner, L. and Aguiló, N. and Thiriard, A. and Coutte, L. and Uranga, S. and Trottein, F. and Martín, C. and Mills, K.H.G. and Locht, C., IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine, Mucosal Immunology, 11, (6), 2018, p1753-1762Journal Article, 2018, DOI , URL
• Wilk, M.M. and Mills, K.H.G., CD4 TRM cells following infection and immunization: Implications for more effective vaccine design, Frontiers in Immunology, 9, (AUG), 2018, p01860-Journal Article, 2018, DOI , URL , TARA - Full Text
• Emma B. O'Connor, Natalia Muñoz-Wolf, Gemma Leon, Ed C. Lavelle, Kingston H. G. Mills, Patrick T. Walsh and Richard K. Porter, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation, PLoS ONE, 15, (11), 2020, pe02-Journal Article, 2020, DOI , TARA - Full Text
• Raverdeau M, Christofi M, Malara A, Wilk M.M, Misiak A, Kuffova L, Yu T, McGinley A.M, Quinn S.M, Massilamany C, Reddy J, Forrester J.V, Mills K.H.G, Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity, EMBO Reports, 20, (5), 2019Journal Article, 2019, DOI , URL
• Quinn S.M, Raverdeau M, McGinley A.M, Mills K.H.G, Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis, European Journal of Immunology, 2019Journal Article, 2019, DOI , URL
• Wilk M.M, Borkner L, Misiak A, Curham L, Allen A.C, Mills K.H.G, Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis, Emerging Microbes and Infections, 8, (1), 2019, p169 - 185Journal Article, 2019, DOI , URL , TARA - Full Text
• Borkner L, Misiak A, Wilk M.M, Mills K.H.G, Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory, Frontiers in immunology, 9, 2018, p1764-Journal Article, 2018, DOI , URL
• E. J. Ryan, E. McNeela, M. Pizza, R. Rappuoli, L. O'Neill and K. H. Mills, Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity, Journal of Immunology (Baltimore, Md, 165, (10), 2000, p5750-9Journal Article, 2000, TARA - Full Text
• Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5Journal Article, 2019, DOI , URL , TARA - Full Text
• Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and AndrÀ, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and BÃŒscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Ä iÄ in-Å ain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De Biasi, S. and Del Zotto, G. and Dela Cruz, G.V. and Delacher, M. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di Santo, J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and Dörner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, A. and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and GrÃŒtzkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and HÀmmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and JÀck, H.-M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), European Journal of Immunology, 49, (10), 2019, p1457-1973Journal Article, 2019, DOI , URL , TARA - Full Text
• Diavatopoulos, D.A. and Mills, K.H.G. and Kester, K.E. and Kampmann, B. and Silerova, M. and Heininger, U. and van Dongen, J.J.M. and van der Most, R.G. and Huijnen, M.A. and Siena, E. and Mielcarek, N. and Ochs, M.M. and Denoël, P. and Berbers, G. and Buisman, A.M. and de Jonge, M.I. and Fenwick, C. and Gorringe, A. and He, Q. and Kelly, D. and Le Grand, R. and Locht, C. and Mascart, F. and Mertsola, J. and Orfao, A. and Pantaleo, G. and Pollard, A.J. and Preston, A. and Read, R. and Sebo, P. and van Els, C. and Vecerek, B. and Londoño-Hayes, P. and de Groot, R., PERISCOPE: road towards effective control of pertussis, The Lancet Infectious Diseases, 19, (5), 2019, pe179-e186Journal Article, 2019, DOI , URL
• Quinn, S.M. and Cunningham, K. and Raverdeau, M. and Walsh, R.J. and Curham, L. and Malara, A. and Mills, K.H.G., Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease, Frontiers in Immunology, 10, (MAY), 2019Journal Article, 2019, DOI , URL
• Zurita, M.E. and Wilk, M.M. and Carriquiriborde, F. and Bartel, E. and Moreno, G. and Misiak, A. and Mills, K.H.G. and Hozbor, D., A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains, Frontiers in Cellular and Infection Microbiology, 9, (APR), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Z. Zas³ona , E. Flis, M.M. Wilk, R.G. Carroll, E.M. Palsson-McDermott, M.M. Hughes, C. Diskin, K. Banahan, D.G. Ryan, A. Hooftman, A. Misiak, J. Kearney, G. Lochnit, W. Bertrams, T. Greulich, B. Schmeck, O.J. McElvaney, K.H.G. Mills, E.C. Lavelle, M. Wygrecka, E.M. Creagh & L.A.J. O'Neill , Caspase-11 promotes allergic airway inflammation, Nature Communications, 2020Journal Article, 2020, URL , TARA - Full Text
• Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833-Journal Article, 2020, DOI , TARA - Full Text
• Damron, F.H. and Barbier, M. and Dubey, P. and Edwards, K.M. and Gu, X.-X. and Klein, N.P. and Lu, K. and Mills, K.H.G. and Pasetti, M.F. and Read, R.C. and Rohani, P. and Sebo, P. and Harvill, E.T., Overcoming waning immunity in pertussis vaccines: Workshop of the national institute of allergy and infectious diseases, Journal of Immunology, 205, (4), 2020, p877-882Journal Article, 2020, DOI , URL , TARA - Full Text
• Mela, V. and Mota, B.C. and Milner, M. and McGinley, A. and Mills, K.H.G. and Kelly, Ã .M. and Lynch, M.A., Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells, Brain, Behavior, and Immunity, 87, 2020, p413-428Journal Article, 2020, DOI , URL
• Edwards, S.C. and Sutton, C.E. and Ladell, K. and Grant, E.J. and McLaren, J.E. and Roche, F. and Dash, P. and Apiwattanakul, N. and Awad, W. and Miners, K.L. and Lalor, S.J. and Ribot, J.C. and Baik, S. and Moran, B. and McGinley, A. and Pivorunas, V. and Dowding, L. and Macoritto, M. and Paez-Cortez, J. and Slavin, A. and Anderson, G. and Silva-Santos, B. and Hokamp, K. and Price, D.A. and Thomas, P.G. and McLoughlin, R.M. and Mills, K.H.G., A population of proinflammatory T cells coexpresses αβ and γΎ T cell receptors in mice and humans, Journal of Experimental Medicine, 217, (5), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Fitzgibbon, G. and Mills, K.H.G., The microbiota and immune-mediated diseases: Opportunities for therapeutic intervention, European Journal of Immunology, 50, (3), 2020, p326-337Journal Article, 2020, DOI , URL , TARA - Full Text
• McGinley, A.M. and Sutton, C.E. and Edwards, S.C. and Leane, C.M. and DeCourcey, J. and Teijeiro, A. and Hamilton, J.A. and Boon, L. and Djouder, N. and Mills, K.H.G., Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells, Immunity, 52, (2), 2020, p342-356.e6Journal Article, 2020, DOI , URL , TARA - Full Text
• Angiari, S. and Runtsch, M.C. and Sutton, C.E. and Palsson-McDermott, E.M. and Kelly, B. and Rana, N. and Kane, H. and Papadopoulou, G. and Pearce, E.L. and Mills, K.H.G. and O'Neill, L.A.J., Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity, Cell Metabolism, 31, (2), 2020, p391-405.e8Journal Article, 2020, DOI , URL , TARA - Full Text
• Locht, C. and Carbonetti, N.H. and Cherry, J.D. and Damron, F.H. and Edwards, K.M. and Fernandez, R. and Harvill, E.T. and Hozbor, D. and Mills, K.H.G. and Rodriguez, M.E. and Mascart, F., Highlights of the 12th International Bordetella Symposium, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71, (9), 2020, p2521-2526Journal Article, 2020, DOI , URL
• Chasaide, C.N. and Mills, K.H.G., Next-generation pertussis vaccines based on the induction of protective t cells in the respiratory tract, Vaccines, 8, (4), 2020, p1-28Journal Article, 2020, DOI , URL , TARA - Full Text
• Finlay, C.M. and Cunningham, K.T. and Doyle, B. and Mills, K.H.G., IL-33-stimulated murine mast cells polarize alternatively activated macrophages, which suppress T cells that mediate experimental autoimmune encephalomyelitis, Journal of Immunology, 205, (7), 2020, p1909-1919Journal Article, 2020, DOI , URL
• Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O†Neill, L.A. and Pickkers, P. and van der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and van der Meer, J.W.M. and van de Veerdonk, F.L. and Dinarello, C.A., Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790), Nature Immunology, 22, (2), 2021, p254 -Journal Article, 2021, DOI , URL , TARA - Full Text
• Kelly Á, Vereker E, Brady M. Barry C, Loscher C, Mills KHG, Lynch MA., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462Journal Article, 2003, DOI , URL , TARA - Full Text
• Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124Journal Article, 2003, DOI , URL
• Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33Journal Article, 2003, DOI , URL
• Cunningham Kyle , Finlay Conor , Mills Kingston H, Helminth Imprinting of Hematopoietic Stem Cells Sustains Anti-Inflammatory Trained Innate Immunity That Attenuates Autoimmune Disease, Journal of Immunology, 206, (7), 2021, p1618 - 1630Journal Article, 2021, DOI , URL
• Borkner L, Curham LM, Wilk MM, Moran B, Mills KHG., IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F⁺ neutrophils., Mucosal immunology, 2021Journal Article, 2021, DOI , TARA - Full Text
• Cunningham KT, Mills KHG., Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation., Transplantation, 2021Journal Article, 2021, DOI
• Borkner, L. and Curham, L.M. and Wilk, M.M. and Moran, B. and Mills, K.H.G., Correction: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils (Mucosal Immunology, (2021), 14, 5, (1183-1202), 10.1038/s41385-021-00407-5), Mucosal Immunology, 14, (5), 2021, p1218-1219Journal Article, 2021, DOI , URL , TARA - Full Text
• Murphy, D.M. and Mills, K.H.G. and Basdeo, S.A., The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research, Frontiers in Immunology, 12, (706583), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Ryan, L. and Mills, K.H.G., Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis, European Journal of Immunology, 52, (1), 2022, p24-33Journal Article, 2022, DOI , TARA - Full Text
• Mills, K.H.G., Innate lymphoid cells recruit T cells to turn up the heat on tumors, Cancer Cell, 40, (4), 2022, p362-364Journal Article, 2022, DOI
• Mills, K.H.G., IL-17 and IL-17-producing cells in protection versus pathology, Nature Reviews Immunology, 2023, p38-54Journal Article, 2023, DOI , TARA - Full Text
• Cervantes-Silva MP, Carroll RG, Wilk MM, Moreira D, Payet CA, O'Siorain JR, Cox SL, Fagan LE, Klavina PA, He Y, Drewinski T, McGinley A, Buel SM, Timmons GA, Early JO, Preston RJS, Hurley JM, Finlay DK, Schoen I, Javier Sánchez-García F, Mills KHG, Curtis AM., The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing., Nature communications, 13, (1), 2022, p7217Journal Article, 2022, DOI , TARA - Full Text
• Mallon PW, Horgan M, McAloon CG, Lunn PD, Little J, Beck A, Bennett A, Shaver N, Conway A, O'Regan R, Whelan B, Rapid Testing Expert Advisory Group, Ireland, Members of the Rapid Testing Expert Advisory Group., Development of a risk assessment profile tool to determine appropriate use of SARS-CoV-2 rapid antigen detection tests for different activities and events in Ireland, since October 2021., Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 27, (3), 2022Journal Article, 2022, DOI
• Curham, L.M. and Mannion, J.M. and Daly, C.M. and Wilk, M.M. and Borkner, L. and Lalor, S.J. and McLoughlin, R.M. and Mills, K.H.G., Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae, European Journal of Immunology, 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Cunningham KT, Mills KHG., Modulation of haematopoiesis by protozoal and helminth parasites., Parasite immunology, 2023, pe12975Journal Article, 2023, DOI , TARA - Full Text
• Baran, M. and Feriotti, C. and McGinley, A. and Carlile, S.R. and Jiang, Z. and Calderon-Gonzalez, R. and Dumigan, A. and Sá-Pessoa, J. and Sutton, C.E. and Kearney, J. and McLoughlin, R.M. and Mills, K.H.G. and Fitzgerald, K.A. and Bengeochea, J.A. and Bowie, A.G., PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection, Cell Reports, 42, (4), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and O†Brien, E.C. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and O†Donnell, J.S. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and O†Neill, L.A.J., Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (Nature Communications, (2023), 14, 1, (3513), 10.1038/s41467-023-39174-1), Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and Brien, E.C.O. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and Donnell, J.S.O. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and Neill, L.A.J.O., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon, Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Diallo, B.K. and Chasaide, C.N. and Wong, T.Y. and Schmitt, P. and Lee, K.S. and Weaver, K. and Miller, O. and Cooper, M. and Jazayeri, S.D. and Damron, F.H. and Mills, K.H.G., Intranasal COVID-19 vaccine induces respiratory memory T cells and protects K18-hACE mice against SARS-CoV-2 infection, npj Vaccines, 8, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Schmitt, P. and Borkner, L. and Jazayeri, S.D. and McCarthy, K.N. and Mills, K.H., Nasal vaccines for pertussis, Current Opinion in Immunology, 84, (102355), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Moran, B. and Smith, C.M. and Zaborowski, A. and Ryan, M. and Karman, J. and Dunstan, R.W. and Smith, K.M. and Hambly, R. and Musilova, J. and Petrasca, A. and Fabre, A. and O'Donnell, M. and Hokamp, K. and Mills, K.H.G. and Housley, W.J. and Winter, D.C. and Kirby, B. and Fletcher, J.M., Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin, The British journal of dermatology, 189, (4), 2023, p447-458Journal Article, 2023, DOI , URL
• Mills, K.H.G., How immunology can help reverse the pertussis vaccine failure, Nature Immunology, 24, (11), 2023, p1779-1780Journal Article, 2023, DOI , URL
• Kelly AM, McCarthy KN, Claxton TJ, Carlile SR, O'Brien EC, Vozza EG, Mills KH, McLoughlin RM., IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection., JCI insight, 9, (13), 2024, pe178216Journal Article, 2024, DOI
• McCarthy KN, Hone S, McLoughlin RM, Mills KHG., IL-17 and IFN-"-producing respiratory tissue resident memory CD4"T cells persist for decades in adults immunized as children with whole cell pertussis vaccines., The Journal of infectious diseases, 2024, pjiae034Journal Article, 2024, DOI
• Leane, C.M. and Sutton, C.E. and Moran, B. and Mills, K.H.G., PD-1 regulation of pathogenic IL-17-secreting γΎ T cells in experimental autoimmune encephalomyelitis, European Journal of Immunology, 2024Journal Article, 2024, DOI , URL
• Pinto, M.V. and Barkoff, A.-M. and Bibi, S. and Knuutila, A. and TerÀsjÀrvi, J. and Clutterbuck, E. and Gimenez-Fourage, S. and Pagnon, A. and van Gaans-van den Brink, J.A.M. and Corbiere, V. and De Montfort, A. and Saso, A. and Jobe, H. and Roetynck, S. and Kampmann, B. and Simonetti, E. and Diavatopoulos, D. and Lambert, E.E. and Mertsola, J. and Blanc, P. and van Els, C.A.C.M. and Kelly, D. and He, Q. and Diavatopoulos, D.A. and Mills, K.H.G. and Kester, K.E. and Silerova, M. and Heininger, U. and van Dongen, J.J.M. and van der Most, R.G. and Huijnen, M.A. and Siena, E. and Mielcarek, N. and Ochs, M.M. and Denoël, P. and Berbers, G. and Buisman, A.M. and de Jonge, M.I. and Fenwick, C. and Gorringe, A. and Le Grand, R. and Locht, C. and Mascart, F. and Orfao, A. and Pantaleo, G. and Pollard, A.J. and Preston, A. and Read, R. and Sebo, P. and van Els, C. and Vecerek, B. and Londoño-Hayes, P. and de Groot, R., A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens, Journal of Immunological Methods, 534, (113758), 2024Journal Article, 2024, DOI , URL
• Douglas, A. and Stevens, B. and Rendas, M. and Kane, H. and Lynch, E. and Kunkemoeller, B. and Wessendorf-Rodriguez, K. and Day, E.A. and Sutton, C. and Brennan, M. and O†Brien, K. and Kohlgruber, A.C. and Prendeville, H. and Garza, A.E. and O†Neill, L.A.J. and Mills, K.H.G. and Metallo, C.M. and Veiga-Fernandes, H. and Lynch, L., Rhythmic IL-17 production by γΎ T cells maintains adipose de novo lipogenesis, Nature, 2024Journal Article, 2024, DOI , URL
• Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KHG, Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines, Journal of Infectious Diseases, 192, (9), 2005, p1628 - 1633Journal Article, 2005, DOI , URL , TARA - Full Text
• Nolan Y, Maher FO, Clarke RM, Brady MT, Bolton AE, Mills KHG, Lynch MA, Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus., Journal of Biological Chemistry, 280, (10), 2005, p9354 - 9362Journal Article, 2005, DOI
• Boyd, A.P., Ross, P.J., Conroy, H., Mahon, N Lavelle, E.C.and Mills, K.H.G., Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death, Journal of Immunology, 175, 2005, p730 - 738Journal Article, 2005, URL , TARA - Full Text
• Loscher, CL Leavy, O. Kelleher, D, *Mills, K.H.G and *Roche, H.M. *Equal contribution, Conjugated linoleic acid suppresses NFkB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction., Journal of Immunology, 175, (8), 2005, p4990 - 4998Journal Article, 2005, URL
• Lelivelt CL, McCabe MS, Newell CA, Desnoo CB, van Dun KM, Birch-Machin I, Gray JC, Mills KH, Nugent JM., Stable Plastid Transformation in Lettuce (Lactuca sativa L.), Plant Molecular Biology, 58, 2005, p763-774Journal Article, 2005, DOI , URL
• Mills, K.H.G., Mahon, B., Griffin, F., Ryan, M, Genetic Institute / Wyeth, IL-12 as an adjuvant for Bordetella pertussis vaccines., 2005, US patent application 11/071,352. Pub No US2005/0158276 A1; US6929794 - 2005-08-16; US2005158276 - 2005-07-21; JP2005112865 - 2005-04-28.Patent, 2005
• Mills, K.H.G., Keogh, B and McGuirk, P, Methods for suppressing immune responses to biological agents. , 2004, UK patent applicationPatent, 2004
• Mills, K.H.G., Keogh, B and McGuirk, P, Cell-based therapies., 2004, UK patent applicationPatent, 2004
• McGuirk, P., Higgins, SC, Mills, K.H.G. , Regulatory cells and the control of respiratory infection. , Current Allergy and Asthma Reports, 5, (1), 2005, p51 - 55Journal Article, 2005, URL
• Noone, C.M. Lewis, EA, Frawely, A.B., Newman, R.W., Mahon, B.P., Mills, K.H.G. and Johnson, P.A. , Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription in murine bone marrow-derived dendritic cells., Journal of General Virology, 86, (7), 2005, p1885-1890Journal Article, 2005, DOI , TARA - Full Text
• Djeha HA, Todryk SM, Pelech S, Wrighton CJ, Irvine AS, Mountain A, Mills, K.H.G., Lipinski KS , Anti-tumour immune response mediated by Adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level co-expression of heat shock protein 70., Cancer Gene Therapy, 12, (6), 2005, p560-571Journal Article, 2005, DOI , URL
• Stephenson, I., Nicholson, K.G. Rudin, A. Colegate, A., Podda, A. Bugarini, R., del Giudice, G., Minutello, A., Bonnington, S., Holmgren, J., Mills, K.H.G, and Zambon, M.C., Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers, The Journal of Virology, 80, (10), 2006, p4962 - 4970Journal Article, 2006, DOI , URL , TARA - Full Text
• Loscher CE, Draper E, Leavy O, Kelleher D, Mills KHG & Roche HM , Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction, Journal of Immunology, 175, (8), 2005, p4990 - 4998Journal Article, 2005, URL , TARA - Full Text
• Sutton, C., Brereton, C., Keogh, B., Mills, K.H.G. Lavelle, E.C., A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis, The Journal of Experimental Medicine, 203, (7), 2006, p1685 - 1691Journal Article, 2006, DOI , URL
• Huo ZM, Sinha R, McNeela EA, Borrow R, Giemza R, Cosgrove C, Heath PT, Mills KHG, Rappuoli R, Griffin GE, Lewis DJM, Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin a in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan, Infection and Immunity, 73, (12), 2005, p6256 - 6265Journal Article, 2005, DOI
• Jarnicki, A.G., Lysaght, J, Todryk, S, Mills, K.H.G, Suppression of antitumor immunity by IL-10 and TGF-b-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells., Journal of Immunology, 177, (2), 2006, p896-904Journal Article, 2006, URL , TARA - Full Text
• Higgins, S., Jarnicki, A, Lavelle, E.C. and Mills, K.H.G, TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells, The Journal of Immunology, 177, 2006, p7980 - 7989Journal Article, 2006, URL , TARA - Full Text
• Braat, H, McQuirk, P., Ten Kate F.J.W., Huibregtse, I., Dunne, P, Hommes, D.W., Deventer, S and Mills, K. H.G. , Prevention of experimental colitis by parenteral administration of a pathogen derived immunomodulatory molecule. , Gut, 56, 2007, p351 - 357Journal Article, 2007, DOI , URL
• Lysaght, J., Jarnicki, A. and Mills, K.H.G. , Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumour immunity. , Cancer Immunology and Immunotherapy, Published online Feb, (DOI 10.1007/s00262-0), 2007, p1367 - 1379Journal Article, 2007, DOI , URL
• Lipinski, K.S., Pelech, S., Mountain, A., Irvine, A.S., Kraaij, R., Bangma, C.H., Mills, K.H.G. and Todryk S.M, Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity. , Cancer Immunology and Immunotherapy, 55, (3), 2006, p347 - 354Journal Article, 2006, DOI , URL
• Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313Journal Article, 2007, DOI , TARA - Full Text
• Mills, KHG, Greally JF, Allogeneic bone marrow transplantation in the rat:Effect of cellular content on graft "take" and graft-versus-host disease, Transplant Proceedings, 15, 1983, p1446 - 1450Journal Article, 1983
• Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J, Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: A role for Th1 cells in the protective immunity , Journal of Neuroimmunology , 125, 2002, p15 - 22Journal Article, 2002, DOI
• MACDONALD, AJ, CD4 T HELPER TYPE 1 AND REGULATORY T CELLS INDUCED AGAINST THE SAME EPITOPES ON THE CORE PROTEIN IN HEPATITIS C VIRUS-INFECTED PERSONS, JOURNAL OF INFECTIOUS DISEASES, 185, 2002, p720 - 727Journal Article, 2002, DOI , URL
• Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina, GLYCEROL-INDUCED SEIZURE: INVOLVEMENT OF IL-1 BETA AND GLUTAMATE, NEUROREPORT, 10, (9), 1999, p1821 - 1825Journal Article, 1999, URL
• Christine E. Loscher, Sheila Donnelly, Marina A. Lynch Kingston H. G. Mills, Induction of inflammatory cytokines in the brain following respiratory infection with bordetella pertussis, Journal of Neuroimmunology, 102, (2), 2000, p172 - 181Journal Article, 2000, DOI , URL
• Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, Marina A. Lynch, INTERLEUKIN-1 BETA-DEPENDENT CHANGES IN THE HIPPOCAMPUS FOLLOWING PARENTERAL IMMUNIZATION WITH A WHOLE CELL PERTUSSIS VACCINE, JOURNAL OF NEUROIMMUNOLOGY, 111, 2000, p68 - 76Journal Article, 2000, DOI , URL
• Conroy, H. Marshall, N.A. and Mills, K.H.G., TLR ligand suppression or enhancement of Treg cell - A double edged sword in immunity to tumors. , Oncogene, 27, (2), 2008, p168 - 180Journal Article, 2008, DOI , URL
• Fennelly, N.F., Sisti, F, Higgins, S.C., Ross, P., van der Heide, H. Mooi, F.R., Boyd, A.P. and Mills, K.H.G., Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses., Infection and Immunity, 76, (3), 2008, p1257 - 1266Journal Article, 2008, DOI , TARA - Full Text
• MILLS, KHG, LIVE VECTORS: ARE SAFE BUT EFFECTIVE VACCINES POSSIBLE?, 2002, - 854-855Miscellaneous, 2002, DOI
• Lavelle EC, Grant G, Pusztai A, Pfüller U, Leavy O, McNeela E, Mills KH, O'Hagan DT., Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2., Journal of Immunology, 107, (2), 2002, p268 - 274Journal Article, 2002, DOI , TARA - Full Text
• RYAN, EJ, Mills, KH, MODULATION OF INNATE AND ACQUIRED IMMUNE RESPONSES BY ESCHERICHIA COLI HEAT-LABILE TOXIN: DISTINCT PRO- AND ANTI-INFLAMMATORY EFFECTS OF THE NONTOXIC AB COMPLEX AND THE ENZYME ACTIVITY, JOURNAL OF IMMUNOLOGY, 165, 2000, p5750 - 5759Journal Article, 2000, URL
• McGuirk, P and Mills K.H.G., PATHOGEN-SPECIFIC REGULATORY T CELLS PROVOKE A SHIFT IN THE TH1/TH2 PARADIGM IN IMMUNITY TO INFECTIOUS DISEASES, TRENDS IN IMMUNOLOGY, 23, 2002, p450-455Review, 2002, DOI , URL
• Peter McGuirk, Chantelle McCann, and Kingston H.G. Mills, Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells: A Novel Strategy for Evasion of Protective T Helper Type 1 Responses by Bordetella pertussis, Journal of Experimental Medicine , 195, (2), 2002, p221 - 231Journal Article, 2002, DOI , TARA - Full Text
• CONWAY, MA, PROTECTION AGAINST BORDETELLA PERTUSSIS INFECTION FOLLOWING PARENTERAL OR ORAL IMMUNIZATION WITH ANTIGENS ENTRAPPED IN BIODEGRADABLE PARTICLES: EFFECT OF FORMULATION AND ROUTE OF IMMUNIZATION ON INDUCTION OF TH1 AND TH2 CELLS, VACCINE, 19, 2001, p1940 - 1950Journal Article, 2001, DOI , URL
• Jarnicki, AJ, Conroy, H. Brereton, C, Donnelly, G., Toomey, D., Walsh, K.,, Sweeney, C., Leavy, O., Fletcher, J., Lavelle, E., Dunne, P. and Mills, K.H.G., Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics, Journal of Immunology, 180, (6), 2008, p3797 - 3806Journal Article, 2008, DOI , URL , TARA - Full Text
• Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969Journal Article, 2008, DOI , URL
• Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190Journal Article, 2003, DOI , URL
• Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562Journal Article, 2003, DOI , URL
• Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128Journal Article, 2010, DOI , URL
• Toomey, D., Conroy, H., Jarnicki, A.G., Higgins, S.C., Sutton, C., Mills, K.H.G. , Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma , Vaccine, 26, (27-28), 2008, p3540-3549Journal Article, 2008, DOI , URL
• Hickey, F.B., Brereton, C.F., Mills, K.H.G. , Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells , Journal of Leukocyte Biology , 84, (1), 2008, p234-243Journal Article, 2008, DOI , TARA - Full Text
• Mills, K.H.G. , TLR9 Turns the Tide on Treg Cells , Immunity, 28, (4), 2008, 518-520Journal Article, 2008, DOI , URL , TARA - Full Text
• N.M. Curtin, K.H.G. Mills and T.J. Connor, Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation: Reversal by the anxiolytic chlordiazepoxide, Brain Behavior and Immunity, 23, (3), 2009, p371 - 379Journal Article, 2009, DOI
• Mills, KH, Induction, function and regulation of IL-17-producing T cells., European Journal of Immunology, 38, (10), 2008, p2636-2649Journal Article, 2008, DOI
• Mills, KH, Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction., Immunology letters, 122, (2), 2009, p108-111Journal Article, 2009, DOI
• N.M. Curtin, N.T. Boyle, K.H.G. Mills and T.J. Connor, Psychological stress suppresses innate IFN-gamma production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide., Brain Behavior and Immunity, 23, 2009, p535 - 547Journal Article, 2009, DOI , TARA - Full Text
• Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027Journal Article, 2009, DOI
• IL-10 and TGF-beta-producing regulatory T cells in infection in, editor(s)Shuiping Jiang , Regulatory cells and Clinical Application, Springer Science and Business Media, LLC , 2008, pp423 - 453, [Dunne PJ, Rowan A, Fletcher JM and KHG Mills]Book Chapter, 2008, DOI
• Brereton CF, Sutton CE, Lalor SJ, Lavelle EC, Mills KH., Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease., Journal of Immunology, 183, (3), 2009, p1715-2173Journal Article, 2009, DOI , TARA - Full Text
• Sutton, C.E., Lalor, S.J., Sweeney, C.M., Brereton, C.F., Lavelle, E.C. and Mills, K.H.G , Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity., Immunity, 31, (2), 2009, p331-341Journal Article, 2009, DOI , TARA - Full Text
• Modified bacterial toxins in, editor(s)Charles J Hackett & Donald A Harn Jr, , Vaccine Adjuvants: Immunological and Clinical Principles., Publisher Humana, 2005, pp296 , [Lavelle EC., Leavy O. Mills KHG. ]Book Chapter, 2005
• Mills, K.H.G., Boyd, A.P., Ross, P.J. and Lavelle, EC., , CyaA in the prophylaxis/treatment of inflammatory and immune-mediated disorders., 2003Patent, 2003
• Walsh, KP, Brady, MT, Finlay, CM, Boon, L, Mills, KH, Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses., Journal of Immunology , 183, (3), 2009, p1577 - 1586Journal Article, 2009, DOI , TARA - Full Text
• de Roos, B, Rungapamestry, V, Ross, K, Rucklidge, G, Reid, M, Duncan, G, Horgan, G, Toomey, S, Browne, J, Loscher, CE, Mills, KH, Roche, HM, Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet., Proteomics, 9, (12), 2009, p3244 - 3256Journal Article, 2009, DOI
• Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610Journal Article, 2009, DOI , URL , TARA - Full Text
• Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM, A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4., The Journal of Nutrition, 139, (12), 2009, p2351-2357Journal Article, 2009, DOI
• Mills KH, Dunne A, Immune modulation: IL-1, master mediator or initiator of inflammation, Nature Medicine, 15, (12), 2009, p1363-1364Review, 2009, DOI , TARA - Full Text
• Dunne PJ, Moran B, Cummins RC and Mills KH , CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. , The Journal of Immunology, 183, 2009, p400 - 410Journal Article, 2009, DOI , TARA - Full Text
• Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C and Mills KHG, Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta, Journal of Immunology, 181, (7), 2008, p4485 - 4494Journal Article, 2008, DOI , URL , TARA - Full Text
• Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607Journal Article, 2010, DOI , URL , TARA - Full Text
• Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607Journal Article, 2010, DOI , URL , TARA - Full Text
• Mills, K.H.G. and Higgins, S., TCD, Compounds and methods for the treatment of autoimmune and inflammatory disorders, 2009, PCT/EP2009/067819Patent, 2009
• Mills, K.H.G., Jarnicki, AJ, Toomey D, TCD, Compositions and methods for the treatment of cancer and infectious diseases, 2009, 12/085787Patent, 2009
• Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH., Response: Characteristics of IL-17-Producing gammadelta T Cells., Immunity, 32, (1), 2010, p3 - 4Journal Article, 2010, DOI
• Mills, K.H.G., Worman, C.P. and Cawley, J.C, Helper/suppressor T cells in B cell malignancies, Br. J. Haematol, 53, 1983, p271 - 275Journal Article, 1983
• Armitage, R.J., Worman, C.P., Mills, K.H.G. and Cawley, J.C, A B cell proliferation with aberrant E-rosette formation: a sequential study with a panel of monoclonal antibodies and other surface markers, Scand. J. Haematol, 30, (3), 1983, p211 - 217Journal Article, 1983
• Mills, K.H.G., Worman, C.P. and Cawley, J.C, Normal human B cells express endogenous E receptor after appropriate in vitro culture, Eur. J. Immunol, 13, 1983, p379 - 382Journal Article, 1983, DOI , URL
• Mills, K.H.G., Armitage, R.J. and Worman, C.P, An indirect technique for the identification and separation of human lymphocyte populations by monoclonal antibodies: a comparison with immunofluorescence techniques, Immunol. Letts , 6, 1983, p241 - 246Journal Article, 1983, DOI , URL
• Worman, C.P., Mills, K.H.G. and Cawley, J.C, Non T lymphoid cells can express T cell surface characteristics: normal, HCL and a range of leukaemia B cells express T cell antigens after appropriate in vitro stimulation, Seminars Oncol, 11, 1984, p401 - 404Journal Article, 1984
• Semenzato, G., Herrman, F. and Mills, K.H.G, T cell subpopulations in B cell chronic lymphocytic leukemias, Clin. Exp. Immunol, 57, (3), 1984, p752 - 754Journal Article, 1984, URL , TARA - Full Text
• Mills, K.H.G. and Cawley, J.C., Stimulated lymphoid cells of B lineage, but not plasma or myeloid cells can express E receptor., Leuk. Res, 9375-380, (3), 1985, p375 - 380Journal Article, 1985, DOI , URL
• Mills, K.H.G., Skehel, J.J. and Thomas, D.B, Conformational dependent recognition of influenza virus haemagglutinin by murine T-helper clones, Eur. J. Immunol, 16, 1986, p276 - 280Journal Article, 1986, DOI , URL
• Mills, K.H.G., Skehel, J.J., Graham, C.M. and Thomas, D.B, Extensive diversity in the recognition of influenza virus haemagglutinin by murine T cell clones, Journal of Experimental Medicine, 163, (6), 1986, p1477 - 1490Journal Article, 1986, URL
• Thomas, D.B., Skehel, J.J., Mills, K.H.G. and Graham, C.M, Suicide selection of murine T-helper clones specific for defined regions of the influenza haemagglutinin molecule, Eur. J. Immunol, 16, 1986, p789 - 793Journal Article, 1986, URL
• Mills, K.H.G, Processing of viral antigens and presentation to class II-restricted T cells, Immunol. Today , 7, (9), 1986, p260 - 263Journal Article, 1986, DOI , URL
• Thomas, D.B., Skehel, J.J., Mills, K.H.G. and Graham, C.M, A single amino acid substitution in influenza haemagglutinin abrogates recognition by monoclonal antibody and a spectrum of subtype-specific L3T4+ T-cell clones, Eur. J. Immunol, 17, 1987, p133 - 136Journal Article, 1987
• Mills, K.H.G., Burt, D.S., Skehel, J.J. and Thomas, D.B, Fine specificity of murine class-II-restricted T cell clones for synthetic peptides of influenza virus haemagglutinin: Heterogeneity of antigen interaction with the T cell and the Ia Molecule, J. Immunol, 140 , 1988, p4083 - 4090Journal Article, 1988, URL
• Mills, K.H.G, Inhibitory effects of monoclonal antibodies to a synthetic peptide of influenza haemagglutinin on the processing and presentation of viral antigens to class II-restricted T cell clones, Immunology, 65, 1988, p365 - 371Journal Article, 1988, URL , TARA - Full Text
• Fletcher, J.M., Lalor, S.J., Sweeney, C.M., Tubridy, N., Mills, K.H.G, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis , Clinical and Experimental Immunology, 162, (1), 2010, p1-11Review Article, 2010, DOI , URL , TARA - Full Text
• McGuirk, P., Higgins, S.C., Mills, K.H.G, The role of regulatory T cells in respiratory infections and allergy and asthma, Current Allergy and Asthma Reports, 10, (1), 2010, p21-28Journal Article, 2010, DOI , URL , TARA - Full Text
• Higgins, S.C., Mills, K.H.G, TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants, Current Infectious Disease Reports, 12, (1), 2010, p4-12Journal Article, 2010, DOI , URL , TARA - Full Text
• Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904Journal Article, 2010, DOI
• O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418Journal Article, 2010, DOI
• Coleman MM, Keane J, Mills KH., Tregs and BCG--dangerous liaisons in TB., Journal of Leukocyte Biology, 88, (6), 2010, p1067 - 1069Journal Article, 2010, DOI
• Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100-111Journal Article, 2011, DOI , URL , TARA - Full Text
• Cheryl M. Sweeney, Roisin Lonergan, Sharee A. Basdeo, Katie Kinsella, Lara S. Dungan, Sarah C. Higgins, Patrick J. Kelly, Lisa Costelloe, Niall Tubridy, Kingston H.G. Mills, Jean M. Fletcher, IL-27 mediates the response to IFN beta therapy in multiple sclerosis patients by inhibiting Th17 cells, Brain, Behavior and Immunity, 25, (6), 2011, p1170-1181Journal Article, 2011, DOI , URL , TARA - Full Text
• Marina A. Lynch and Kingston H.G. Mills, Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases, Brain, Behavior, and Immunity, 26, (1), 2011, p1-10Journal Article, 2011, DOI , URL , TARA - Full Text
• Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH, Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis., Journal of Immunology , 185, (3), 2010, p1711-9Journal Article, 2010, DOI , URL , TARA - Full Text
• Lalor, S.J., Dungan, L.S., Sutton, C.E., Basdeo, S.A., Fletcher, J.M., Mills, K.H.G., Caspase-1-processed cytokines IL-1β and IL-18 promote IL-17 production by γδ and CD4 T cells that mediate autoimmunity, Journal of Immunology, 186, (10), 2011, p5738-5748Journal Article, 2011, DOI
• Brereton, C.F., Sutton, C.E., Ross, P.J., Iwakura, Y., Pizza, M., Rappuoli, R., Lavelle, E.C., Mills, K.H.G., Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production, Journal of Immunology, 186, (10), 2011, p5896-5906Journal Article, 2011, DOI
• McLoughlin, R.M., Mills, K.H.G., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma, Journal of Allergy and Clinical Immunology, 127, (5), 2011, p1097-1107Journal Article, 2011, DOI
• Eve Draper, Clare M. Reynolds, Mary Canavan, Kingston H. Mills, Christine E. Loscher, and Helen M. Roche, Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma, Journal of Nutritional Biochemistry, 22, (8), 2011, p784-790Journal Article, 2011, DOI , URL , TARA - Full Text
• McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH, Roche HM, Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis., Diabetes, 60, (6), 2011, p1688-98Journal Article, 2011, DOI
• Dunne A, Marshall NA, Mills KH, TLR based therapeutics., Current opinion in pharmacology, 11, (4), 2011, p404-11Review, 2011, DOI
• Masters, S.L., Mielke, L.A. Cornish, A.L., Sutton, C.E., Cengia, L., Roberts, A.W., Wicks, I.P. Mills, K.H.G. and Croker, B.A. , Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production , EMBO Reports, 11, (8), 2010, p640 - 646Journal Article, 2010, DOI
• Dungan, L.S., and Mills, K.H.G , Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17. , Cytokine, 56, (1), 2011, p126 - 132Journal Article, 2011, DOI
• Mills, K.H.G, Cawley, J.C., ABNORMAL MONOCLONAL ANTIBODY-DEFINED HELPER-SUPPRESSOR T-CELL SUBPOPULATIONS IN MULTIPLE-MYELOMA - RELATIONSHIP TO TREATMENT AND CLINICAL STAGE , British Journal of Haematology, 53, (2), 1982, p271 - 275Journal Article, 1982
• Marshall NA, Galvin KC, Corcoran AM, Boon L, Higgs R, Mills KH, Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-ã+IL-17+ polyfunctional T-cells that mediate rejection of murine tumors, Cancer Research, 72, (3), 2012, p581-591Journal Article, 2012, DOI , URL
• Evasion of immune responses by bacteria. in, editor(s)S. Kaufmann and M. Steward , Topley and Wilson's Microbiology and Microbial Infections: Immunology Volume, London, Hodder Arnold Publishers Ltd, 2005, pp645 - 674, [Mills, K.H.G. and Boyd, A]Book Chapter, 2005
• Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424Journal Article, 2012, DOI
• Modified Bacterial toxins in, editor(s)D. Harn and C.J Hackett , Vaccine Adjuvants: Immunological and Clinical Principles, Humana Press, 2005, pp113 - 155, [Lavelle, E., Leavy, O., Mills, K.H.G.]Book Chapter, 2005
• Induction and detection of T cell responses in, editor(s)A. Robinson, M.J. Hudson, and M. P. Cranage , Methods in Molecular Medicine. Vol 87: Vaccine protocols, 2nd Edition, NJ, USA, Humana Press Inc., 2003, pp255 - 278, [Mills, K.H.G.]Book Chapter, 2003
• Bailey, C.J., Jeffroy, P. and Mills, K.H.G., An examination of the distribution of Hen- and Goose-type lysozyme in anseriforms, Comp. Biochem. Physiol., 553, 1977, p429 - 433Journal Article, 1977
• Mills, K.H.G., Greally, J.F., Temperley, I.J. and Mullins, G.M., Haematological and immune-suppressive effects of total body irradiation in the rat, Ir J. Med. Sci., 149, 1980, p201 - 208Journal Article, 1980
• Worman, C.P., Mills, K.H.G., Linch, D.C., Beverley, P.C.L., Goldstone, A.H. and Cawley, J.C., Amegokaryocytic thrombocytopenia associated with an excess of Leu 2a+ suppressor cells, Scand. J. Haematol., 28, 1982, p215 - 219Journal Article, 1982
• Mills, K.H.G., Worman, C.P. and Cawley, J.C., T cell subsets in B-chronic lymphocytic leukaemia (CLL)., Br. J. Haematol., 50, 1982, p710 - 712Journal Article, 1982
• Mills, K.H.G. and Cawley, J.C., Suppressor T cells in B-cell chronic lymphocytic leukaemia: relationship to clinical stage., Leuk. Res, 6, 1982, p653 - 657Journal Article, 1982, DOI , URL
• Burt, D.S., Mills, K.H.G., Skehel, J.J. and Thomas, D.B., Diversity of the class II (I-Ak/I-Ek) restricted T-cell repertoire for influenza haemagglutinin and antigenic drift: six non-overlapping epitopes on the HA1 sub-unit are defined by synthetic peptides, Journal of Experimental Medicine, 170, (2), 1989, p383 - 397Journal Article, 1989, TARA - Full Text
• Mills, K.H.G., Nixon, D., McMichael, A., T cell strategies in AIDS vaccine: MHC restricted T-cell responses to HIV proteins, AIDS 13, suppl. 1, 1989, pS101 - S110Journal Article, 1989
• Mills, K.H.G., Recognition of foreign antigen by T cells and their role in immune protection., Cur. Opin. Infect. Dis., 2, (6), 1989, p804 - 814Journal Article, 1989
• Skehel, J.J., Barnett, B.C., Burt, D.S., Daniels, R.S., Douglas, A.R., Graham, C.M., Hodgson, J., Knossow, M., Mills, K.H.G., Riska, P.F., Thomas, D.B., Weis, W.,Wiley, D.C. & Wrigley, N.C., Immune recognition of influenza virus haemagglutinin, Philos. Trans. Royal Soc. London B., 323, 1989, p479 - 483Journal Article, 1989
• Mills, K.H.G., Kitchin, P.A., Mahon, B.P., Barnard, A.L., Adams, S.E., Kingsman, S.M. and Kingsman, A.J., HIV p24-specific T cell clones from immunized primates recognize highly conserved regions of HIV-1, J. Immunol., 144, 1990, p1677 - 1683Journal Article, 1990, URL
• Almond, N., Page, M., Mills, K.H.G., Jerkins, A., Ling, C., Thorpe, R. and Kitchin, P., The production and purification of PCR derived recombinant simian immunodeficiency virus p27 gag protein: its use in detecting serological and T-cell responses in macaques., J. Virol. Methods, 28, 1990, p321 - 326Journal Article, 1990
• Page, M., Mills, K.H.G., Schild, G.C., Ling, C., Patel, V., McKnight, A., Barnard, A.L., Dilger, P. and Thorpe, R., Studies on the immunogenicity of CHO cell-derived recombinant gp120 (HIV1-IIIb)., Vaccine, 9, 1991, p47 - 52Journal Article, 1991
• Stott, E.S., Chan, W.L., Mills, K.H.G., Page, M., Taffs, F., Cranage, M., Greenaway P and Kitchin P., Protection of cynomolgus macaques against simian immunodeficiency virus by a whole fixed infected cell vaccine, Lancet, 336, 1991, p1536 - 1541Journal Article, 1991
• Katrak, K., Mahon, B.P., Minor, P.D. and Mills, K.H.G., Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus, Journal of General Virology, 72, 1991, p1093 - 1098Journal Article, 1991, URL , TARA - Full Text
• Mills, K.H.G., Barnard A.L., Williams, M., Stott, J.F., Silvera, P., Page, M., Taffs, F., Kingsman, A.S., Adams, S.E., Almond, N., Kitchin, P.A., Jones, W.C., Vaccine-induced CD4+ T cells against the simian immunodeficiency virus gag protein: epitope specificity and relevance to protective immunity, J. Immunol., 147, 1991, p3560 - 3567Journal Article, 1991, URL
• Stott, E.J., Kitchin, P.A., Page, M., Flanagan, B., Taffs, L.F., Chan, W.L., Mills, K.H.G., Silvera, P. and Rodgers, A., Anti cell antibody in macaques., Nature, 353, (393), 1991Journal Article, 1991, DOI
• Burnette, W.N., Mar, V.L., Bartley, H.R., Mills, K.H.G. et al., The Molecular engineering of pertussis toxoid, Dev. Biol. Stand., 73, 1991, p75 - 78Journal Article, 1991
• Cranage, M., Stott, J., Mills, K.H.G., Ashworth, T., Taffs, F., Farrar, G., Chan, W.L., Page, M., Kithcin, P. and Greenaway, P., Vaccine studies with the 32H reisolate of SIV mac251: an overview., AIDS Res. Hu. Retrovir., 8, 1992, p1479 - 1481Journal Article, 1992
• Mills, K.H.G., Page, M., Chan, W.L., Kitchin, P., Stott, E.J., Taffs, F., Jones, W et al., Protection against SIV infection in macaques by immunization with inactivated virus from the BK28 molecular clone but not with BK28-derived recombinant env and gag proteins, J. Med. Primatol., 21, 1992, p50 - 58Journal Article, 1992
• Jones, W.C., Barnard, A.L., Slade, A. and Mills, K.H.G., Heterogeneity in the recognition of the SIV envelope glycoprotein by CD4+ T cell clones from immunized macaques, J. Immunol., 149, 1992, p3120 - 3126Journal Article, 1992, URL
• Katrak, K., Mahon, B.P., Jones, W., Brautigam, S. and Mills, K.H.G., Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro, J. Immunol. Methods, 156, 1992, p247 - 254Journal Article, 1992, URL
• Mahon, B.P., Katrak, K. and Mills, K.H.G. , Poliovirus-specific murine CD4+ T cell clones recognise serotype specific epitopes on VP1 and VP3 and cross reactive epitopes on VP4, J. Virol., 66, 1992, p1479 - 1481Journal Article, 1992
• Mills, K.H.G., Page, M., Kitchin, P., Chan, L., Jones, W., Silvera, P., Corcoran, T., Flanagan, B., Ling, C., Thiriart, C., DeWilde, M., Bruck, C., Rud, E. Clark, B. & Stott, E.J., Immunization of macaques with SIV env recombinants: Specificity of T cell and antibody responses and evaluation of protective efficacy, J. Med. Primatol., 22, 1993, p20 - 28Journal Article, 1993
• O'Hagan, D.T. Mc Gee, J.P., Holmgren, J., Mowat, A., Donachie A.M., Mills, K.H.G., Gaisford, W., Rahman, D. and Challcombe, S.J., Biodegradable microparticles for oral immunization, Vaccine, 11, 1993, p149 - 157Journal Article, 1993, DOI , URL
• Mills, K.H.G., Barnard, A.L., Watkins, J. and Redhead, K., Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model, Infect. Immun., 61, (2), 1993, p399 - 410Journal Article, 1993, URL , TARA - Full Text
• Redhead, K., Barnard, A., Watkins, J. and Mills, K.H.G., Effective immunization against Bordetella pertussis respiratory infection of mice is dependant on the induction of cell mediated immunity, Infection and Immunity, 61, (8), 1993, p3190 - 3198Journal Article, 1993, URL , TARA - Full Text
• Mills, K.H.G., Redhead, K., Cellular immunity in pertussis , Journal of Medical Microbiology, 39, 1993, p163 - 164Journal Article, 1993
• Kent K.A., Kitchin, K., Mills, K.H.G. Page, M., Taffs, F., Corcoran, T., Silvera, P., Flanagan B., Powell, C., Rose, J. Ling, C., Aubertin A.M. and Stott, E.J., Passive immunization of cynomolgus macaques with immune sera or a pool of neutralizing monoclonal antibodies failed to protect against challenge with SIV mac251, AIDS Res. Hu. Retrovir., 10, (2), 1994, p189 - 194Journal Article, 1994
• Mills, K.H.G. and Jones W.C. , CD4+ T cell responses to Simian immunodeficiency virus, Cur. Topics Immunol. Microbiol., 188, 1994, p161 - 174Journal Article, 1994
• Mahon, B.P., Katrak, K., Nomoto, A., Macadam A., Minor, P.D. and Mills, K.H.G., Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor, Journal of Experimental Medicine, 181, (4), 1995, p1285 - 1292Journal Article, 1995, TARA - Full Text
• Cahill, E.S., O'Hagan, D.T., Illum, L., Barnard, A., Mills, K.H.G. and Redhead, K., Immune responses and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles, Vaccine, 13, 1995, p455 - 462Journal Article, 1995, DOI , URL
• Moore, A, McQuirk P, Adams S., Jones, W.C, McGee, J.P., O'Hagan, D. and Mills, K.H.G., Induction of HIV-specific CD8+ CTL and CD4+ Th1 cells by immunization with recombinant gp120 entrapped in biodegradable microparticles, Vaccine, 13, 1995, p1741 - 1749Journal Article, 1995, DOI , URL
• Barnard, A, Mahon, B.P., Watkins, J., Redhead, K. and Mills, K.H.G., Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T cell subsets as Th1, Th2 or Th0, Immunology, 87, (3), 1996, p372 - 380Journal Article, 1996, URL , TARA - Full Text
• Mahon, B. P., Ryan, M. Griffin, F. Mills, K.H.G., Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells, Infection and Immunity, 64, (12), 1996, p5295 - 5301Journal Article, 1996, URL , TARA - Full Text
• Ryan, M., Gothefors, Storsaeter J. and Mills, K. H. G., Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine: comparison of the T cell cytokine profiles in infants and mice, Dev. Biol. Stand., 89, 1997, p251 - 259Journal Article, 1997
• Ryan, M., Murphy, G., Gothefors, L., Nilsson, L, Storsaeter J. and Mills, K.H.G., Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 Th cells, J. Infect. Dis., 175, 1997, p1246 - 1250Journal Article, 1997, URL
• Mahon B.P, Griffin F., Sheahan, B. and Mills, K.H.G., Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- × receptor or immunoglobulin Ý chain genes, Journal of Experimental Medicine, 186, (11), 1997, p1843 - 1851Journal Article, 1997, URL , TARA - Full Text
• Ryan, M. Murphy, G Nilsson, L., Shackley, F., Gothefors, L., Ømar, K., Miller, E. Storsaeter, J. and Mills, K.H.G., Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children, Immunology, 93, (1), 1998, p1 - 10Journal Article, 1998, DOI , TARA - Full Text
• Mills, K.H.G., Ryan, M., Ryan, E. and Mahon, B. P., A murine model in which protection correlates with pertussis vaccine efficacy in children demonstrates complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis, Infection and Immunity, 66, (2), 1998, p594 - 602Journal Article, 1998, URL , TARA - Full Text
• McGuirk, P. Mahon, B.P., Griffin, F. and Mills K.H.G., Compartmentalization of T cell responses following infection with B. pertussis: hyporesponsiveness of lung T cell are associated with modulated expression of the costimulatory molecule CD28, Eur. J. Immunol., 28, (1), 1998, p153 - 163Journal Article, 1998, DOI , URL
• Mills, K.H.G., Brady, M. Ryan, E. and Mahon B.P., A respiratory challenge model for infection with Bordetella pertussis: application in assessment of pertussis vaccine potency and in definition of the mechanism of protective immunity, Dev. Biol. Stand., 95, 1998, p31 - 41Journal Article, 1998
• Ryan, M. McCarthy, L., Mahon, B, Rappuoli, R. Mills K.H.G., Pertussis Toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28, International Immunology, 10, (4), 1998, p651 - 662Journal Article, 1998, URL , TARA - Full Text
• Mahon, B. P., Johnson, P. Moore, A. and Mills, K.H.G., Approaches to New Vaccines, Crit. Rev. Biotech., 18, (1), 1998, p257 - 281Journal Article, 1998
• Brady, M, Mahon B.P. and Mills, K. H. G., Pertussis infection and vaccination induces Th1 cells and does not enhance allergy, Immunol. Today, 19, 1998, p534Journal Article, 1998, DOI , URL
• Moore, A., McCarthy, L. and Mills, K.H.G., The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a recombinant HIV protein from Th2 to Th1, Vaccine, 17, (20-21), 1999, p2517 - 2527Journal Article, 1999, DOI , URL
• Mahon, B.P. and Mills, K.H.G., Interferon-gamma mediated immune effector mechanisms against Bordetella pertussis, Immunol. Letts., 68, 1999, p213 - 217Journal Article, 1999
• Almond, N, Jenkins, A., Jones, S., Silvera, P., Kent, K., Mills, K.H.G. and Stott, E.J., The Appearance of escape variants in vivo does not account for the failure of recombinant envelope Vaccines to protect against simian immunodeficiency virus, Journal of General Virology, 80, 1999, p2375 - 2382Journal Article, 1999, URL
• Brady, M.T. O'Neill, S.M. Dalton, J.P. and Mills, K.H.G., Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis, Infection and Immunity, 67, 1999, p5372 - 5378Journal Article, 1999, URL , TARA - Full Text
• O'Keeffe J, Mills K. H.G., Jackson J, Feighery C, T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC), Clin. Exp. Immunol., 117, 1999, p269 - 276Journal Article, 1999, DOI , URL
• Ryan, E.J. McNeela, E, Murphy, G., Stewart, H., O'Hagan, D. Pizza, M, Rappuoli, R. and Mills K.H.G., Mutants of E. coli heat labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the non-toxic AB complex and enzyme activity on Th1 and Th2 cells, Infection and Immunity, 67, 1999, p6270 - 6280Journal Article, 1999, URL , TARA - Full Text
• O'Neill, S.M., Brady, M.T., Callanan, J.J., Mulcahy, G, Joyce, P., Mills, K.H.G. and Dalton, J.P., Fasciola hepatica infection downregulates Th1 responses in mice, Parasite Immunol., 22, (3), 2000, p147 - 156Journal Article, 2000, DOI , URL
• McGuirk, P. and Mills, K.H.G., A regulatory role for IL-4 in differential inflammatory responses in the lung following infection of mice primed with Th1- or Th2-inducing pertussis vaccines, Infection and Immunity, 68, (3), 2000, p1383 - 1391Journal Article, 2000, URL , TARA - Full Text
• Conroy H, Galvin KC, Higgins SC, Mills KH, Gene silencing of TGF-ß1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells., Cancer Immunology & Immunotherapy, 61, (3), 2012, p425-431Journal Article, 2012, DOI
• Sisti F, Fernández J, Higgins SC, Casabuono A, Couto A, Mills KH, Hozbor D, A deep rough type structure in Bordetella bronchiseptica lipopolysaccharide modulates host immune responses., Microbiology and immunology, 55, (12), 2011, p847-854Journal Article, 2011, DOI
• Byrne WL, Mills KH, Lederer JA, O'Sullivan GC, Targeting regulatory T cells in cancer., Cancer research, 71, (22), 2011, p6915-6920Journal Article, 2011, DOI
• McGuirk, P. and Mills, K.H.G., Direct anti-inflammatory effect of a bacterial virulence factor: IL-10-dependent suppresssion of IL-12 production by filamentous haemagglutinin from Bordetella pertussis, Eur. J. Immunol., 30, 2000, p415 - 422Journal Article, 2000, DOI , URL
• Mills KH, TLR-dependent T cell activation in autoimmunity., Nature Reviews Immunology, 11, (12), 2011, p807-22Journal Article, 2011, DOI , TARA - Full Text
• Mahon, B.P., Brady, M.T. and Mills, K. H. G., Protection against Bordetella pertussis in mice in the absence of circulating antibody; implications for long term immunity in children, J. Infect. Dis., 181, 2000, p2087 - 2091Journal Article, 2000, DOI , URL
• Johnson, P.A., Conway, M., Daly, J., Nicolson C., Robertson J. and Mills K.H.G., Plasmid DNA coding for influenza virus haemagglutinin induces Th1 cells and protection against respiratory infection despite its limited ability to generate antibody responses, Journal of General Virology, 81, 2000, p1737-1745Journal Article, 2000, URL , TARA - Full Text
• Ryan E.J., Nilsson, L, Kjellman, N.-I. M., Gothefors, L and Mills K.H.G., Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens, Clinical and Experimental Immunology, 121, (2), 2000, p193 - 200Journal Article, 2000, DOI , TARA - Full Text
• McGuirk P. Johnson, Ryan, E.J. and Mills K.H.G., Filamentous Haemagglutinin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens, J. Infect. Dis., 182, 2000, p1286 - 1288Journal Article, 2000, DOI , URL
• McNeela, EA, O'Connor, D., Jabbal-Gill, I., Illum, L., Davis, S.S., Pizza, M., Peppoloni, S., Rappuoli, R. and Mills, K.H.G., A mucosal vaccine against diphtheria: Formulation of cross reacting material (CRM197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery, Vaccine, 19, (9-10), 2000, p1188 - 1198Journal Article, 2000, DOI , URL
• Mills, K.H.G., Review: Immunity to Bordetella pertussis, Microbes and Infection, 3, 2001, p293 - 304Journal Article, 2001, DOI , URL
• Pizza, M., Giuliani, M.M., M.R. Fontana, E. Monacai, G. Douce, G. Dougan, K.H.G. Mills, R. Rappuoli, and G. Del Giudice., Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants, Vaccine, 19, 2001, p2534 - 2541Journal Article, 2001, DOI , URL
• Ryan, E.R., Daly, L. and Mills K.H.G., Immunomodulators and delivery systems for vaccination by mucosal routes, Trends Biotech., 19, (8), 2001, p293 - 304Journal Article, 2001, DOI , URL
• McNeela, E. and Mills, K.H.G., Manipulating the immune system - humoral versus cell-mediated immunity, Advanced Drug Delivery Reviews, 51, 2001, p41 - 52Journal Article, 2001, DOI , URL
• O'Neill, Mills, K.H.G. and Dalton, J.P., Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific IFN-gamma production in vivo, Parasite Immunol., 23, (10), 2001, p541 - 548Journal Article, 2001, DOI , URL
• Mills, K.H.G., Cosgrove, C., McNeela E.A., Sexton, A., Giemza, R., Jabbal-Gill, I., Church, A., Lin, W., Illum, L., Podda, A., Rappuoli, R., Pizza, M. Griffin, G.E. and Lewis, D.J.M., Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a, Infection and Immunity, 71, (2), 2003, p726 - 732Journal Article, 2003, DOI , TARA - Full Text
• Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33Journal Article, 2003, DOI , URL
• Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124Journal Article, 2003, DOI , URL
• Kelly, A., Vereker, E., Brady, M., Brooks, C., Loscher, C, Mills, K.H.G. and Lynch, M.A., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta induced inhibition of long term potentation in the rat dentate gyrus, J. Biol Chem., 278, (21), 2003, p19453 - 19462Journal Article, 2003, DOI , URL
• Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190Journal Article, 2003, DOI , URL
• Lavelle, E., McNeela, E., Armstrong, M., Leavy, O., Higgins, S.C. and Mills K.H.G., Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation, The Journal of Immunology, 171, 2003, p2384 - 2392Journal Article, 2003, URL , TARA - Full Text
• Higgins, S., Lavelle, E., McCann, C., Keogh, B., McNeela, E, Byrne, P., O'Gorman, B., Jarnicki, A., McGuirk, P. and Mills, K.H.G., Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology, Journal of Immunology, 171, (6), 2003, p3119 - 3127Journal Article, 2003, URL , TARA - Full Text
• Brady, M. MacDonald, A., Rowan, A. and Mills K.H.G., Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes, EUROPEAN JOURNAL OF IMMUNOLOGY, 33, (12), 2003, p3448 - 3457Journal Article, 2003, DOI , URL
• Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562Journal Article, 2003, DOI , URL
• Lavelle, E., McGuirk and Mills, K.H.G., Molecules of infectious agents as immunomodulatory drugs, Current Topics in Med. Chem., 4, (5), 2004, p499 - 508Journal Article, 2004, URL
• McNeela, E., Jabbal-Gill, E. Illum, L., Pizza, Rappuoli, R., Podda, A., Lewis, D.M. and Mills, K.H.G., Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: correlation between toxin neutralizing antibody and Th2 responses, VACCINE, 22, (8), 2004, p909 - 914Journal Article, 2004, DOI , URL
• Ross, P.J., Lavelle, E.C., Mills, K.H.G. and A.P. Boyd., Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells, Infection and Immunity, 72, (3), 2004, p1568 - 1579Journal Article, 2004, DOI , TARA - Full Text
• Mills, K.H.G. and McGuirk, P., Antigen-specific regulatory T cells - their induction and role in infection, Seminars in Immunology, 16, (2), 2004, p107 - 117Journal Article, 2004, URL
• Bowe, F., Lavelle, E.C., McNeela, E. A., Hale, C., Clare, S., Arico, B., Giuliani, M.M., Rae, A., Huett, A., Rappuoli, R., Dougan, G. and Mills, K. H.G., Mucosal vaccination against serogroup B meningococcus:Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin, Infection and Immunity, 72, (7), 2004, p4052 - 4060Journal Article, 2004, DOI , TARA - Full Text
• Daly, L.M., Johnson, P.A., Nicolson, C., Robertson, J. and Mills, K.H.G., Innate IL-10 promotes the induction of Th2 responses with plasmid DNA expressing HIV gp120, Vaccine, 23, 2005, p963 - 974Journal Article, 2005, DOI , URL
• An indirect rosette technique for the identification and separation of lymphocyte subpopulations by monoclonal antibodies in, Immunological techniques, Methods in Enzymology, Florida, USA, Academic Press, 1986, pp726 - 737, [Mills, K.H.G.]Book Chapter, 1986
• In vitro culture of T cell lines and clones in, editor(s)G.B. Klaus , Lymphocytes: A practical approach, Oxford, IRL Press, 1987, pp133 - 147, [Taylor, P.M., Thomas, D.B. and Mills, K.H.G.]Book Chapter, 1987
• Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T-cell recognition of the HIV-p24 protein. in, editor(s)F. Brown, R. Chanock, H.S. Ginsberg and R. Lerner , Vaccines 90: Modern approaches to new vaccines including the prevention of AIDS, Cold Spring Harbor Laboratory, New York, 1990, pp213 - 218, [Mills, K.H.G., Barnard, A.L., Mahon, B.P., Kitchin, P.A., Adams, S.E., Kingsman, A.M. and Kingsman, A.J.]Book Chapter, 1990
• Titration of SIV MAC 251 (32H isolate) in cynomolgus macaques for use as a challenge in vaccination studies in, editor(s)H. Schellekens and M.C. Horzinek , Animal models for AIDS, Elsevier Science Publishers, 1990, pp115 - 129, [Kitchin, P.A., Cranage, M.P., Almond, N., Barnard, A., Baskerville, A., Corcoran, T., Fromlhloc, C. Greenway, P., Grief, C., Jerkins, A., Kent, K., Mahon, B., Mills, K.H.G., Page, M., Silvera, P., Szotyori, Z., Taffs, F. and Stott, E.J.]Book Chapter, 1990
• Mills, K.H.G., Barnard, A., Watkins, S. and Redhead, K., Specificity of the T cell response to Bordetella pertussis in aerosol infected mice, Proceedings of the 6th international symposium on pertussis, Dept. Health and Human Services, United States Public Health Service, Bethesda, Ma, USA, 1990, pp166 - 174Conference Paper, 1990
• Mills, K.H.G., Redhead, K. and Watkins, J., T-cell immunity in protection against Bordetella pertussis infection in mice, J. Med. Microbiol., 35, 1991, p175 - 176Journal Article, 1991
• Prospects for immunization against HIV infection: Immunology of HIV infection in, A.G. Bird , Immunology and Medicine Series. Vol. 17, Kluwer Academic Publishers, 1991, pp155 - 176, [Mills, K.H.G.]Book Chapter, 1991
• Vaccination against simian-immunodeficiency virus infection of macaques in, editor(s)M. Girard and L. Valette , Retroviruses of human AIDS and related animal diseases. Sixieme colloque des cent gardes 1991, Pasteur Merieux, 1991, pp261 - 265, [Stott, J., Cranage, M., Kitchin, P., Farrar, G., Taffs, F., Ashworth, E., Page, M., Chan, L., Baskerville, A., Greenaway, P. and Mills, K.H.G.]Book Chapter, 1991
• Cellular immune responses to pertussis toxin in aerosol infected mice in, editor(s)Witholt et al , Bacterial protein toxins, Gustav Fischer, 1992, pp306 - 307, [Redhead, K., Barnard, A., Watkins, J. and Mills, K.H.G.]Book Chapter, 1992
• Barnard, A.L., Redhead, K. and Mills, K.H.G., Induction of Th1 and Th2 cells by immunization or respiratory infection with Bordetella pertussis, Biologicals, 21, (1), 1993, p32Journal Article, 1993, DOI , URL
• Redhead, K., Watkins, J., Barnard, A. and Mills, K.H.G., Comparison of humoral and cellular immune responses to pertussis immunization and infection in a murine model, Biologicals, 21, 1993, p18 - 19Journal Article, 1993, DOI , URL
• Mills, K.H.G., Barnard, A., Watkins, J. and Redhead, K., The critical role of T cells in the induction of protective immunity to B. Pertussis with acellular vaccines based on recombinant pertussis toxin, Biologicals, 21, 1993, p19 - 20Journal Article, 1993, DOI , URL
• Vaccination of macaques against SIV infection and the significance of host (C8166) cell components in, editor(s)Des, F. Brown, R. Chanock, H.S. Ginsberg and R. Lerner. , Vaccines 93: Modern approaches to new vaccines including the prevention of AIDS, New York, Cold Spring Harbor Laboratory, 1993, pp71 - 76, [Kitchin, P. Mills, K.H.G., Page, M. Taffs, F., Chan, W.L., Cranage, M., Farrar, G., Greenway, P., and Stott, J.]Book Chapter, 1993
• Animal models in the development of AIDS vaccines in, editor(s)M. Girard and L. Valette , Retroviruses of human AIDS and related animal diseases, Pasteur Merieux, 1994, pp131 - [Stott, E.J., Almond, N., Kent, K.A., Chan, W.L., Cranage, M.P., Kitchin, P.A., Mills, K.H.G., Page, M., and Rud, E]Book Chapter, 1994
• The primate (non-human) immune system in, editor(s)I. Roitt and P. Delves, W.B. , Encyclopaedia of Immunology, Sanders Scientific Publishers, 1992, pp1269 - 1292, [Mills, K.H.G.]Book Chapter, 1992
• T cells and protective immunity to human and simian immunodeficiency viruses in, editor(s)D.B. Thomas, Marcel Decker , Viruses and the cellular immune response, New York, 1993, pp127 - 164, [Mills, K.H.G.]Book Chapter, 1993
• Cellular and humoral immune responses to poliovirus and tetanus following priming vaccination of SIV infected macaques in, Molecular pathological aspects of animal models of HIV infection, Basel, Karger Medical and Scientific Publishers, 1993, pp75 - 85, [Mills, K.H.G., Jones, W.C., Mahon, B.P., Katrak, K., Taffs, F., Stott, E.J. and Page, M.]Book Chapter, 1993
• Mammalian cell cloning in, editor(s)J. Davis , Basic Animal cell culture: A practical approach, IRL Press at Oxford University press, 1994, pp181 - 222, [Hayashi, I., Hayashi, J., Hoshi, H., Kawamoto, T., Mc Keehan, W., Matsuzaki, R. Mills, K.H.G. , Okamoto, T., Serrero, G., Sussman D., and Kan, M.]Book Chapter, 1994
• Induction and detection of T cell responses in, editor(s)A. Robinson , Methods in Molecular Medicine - Vaccine protocols, NJ, USA, Humana Press Inc, 1996, pp197 - 221, [Mills, K.H.G.]Book Chapter, 1996
• Ryan, M, and Mills K.H.G., The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells, Biochem. Soc. Trans., 25, (1), 1997, p126SJournal Article, 1997
• Mahon B. P. Ryan, M. Griffin, F., and Mills K.H.G.(ed.), Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: clearance of primary infection is not enhanced by therapeutic IL-12, Biochem. Soc. Trans., 25, (1), 1997, 341S pProceedings of a Conference, 1997
• Mc Guirk P., Mahon B.P., Griffin, F. and Mills K.H.G.(ed.), Local cellular immunity to the respiratory pathogen Bordetella pertussis: role of costimulatory molecules, Biochem. Soc. Trans., 25, (1), 1997, 124S pProceedings of a Conference, 1997
• Johnson, P. A., Conway, M., Cox-Brokstad, R, Haaheim, L., Daly, J., Robertson, J. and Mills, K.H.G., Selective induction of Th1 cells with plasmid DNA coding for influenza virus haemagglutinin, Proceeding of European 2nd Biotechnology meeting on Vaccinology, edited by P. Roy and C. Leclerc. , 1998, pp42 - 43Conference Paper, 1998
• Mills, K.H.G., Adjuvants for Vaccines: General considerations. Rapporteur's Summary., Modulation of the immune response to vaccine antigens, Dev. Biol. Stand., 92, (29), 1998Conference Paper, 1998
• Murine T cell culture in, editor(s)Rowland Jones, S and McMichael A. , Lymphocytes - A Practical Approach, Oxford, IRL Press, 1999, pp95 - 134, [Mills, K.H.G.]Book Chapter, 1999
• Mills, K.H.G. Ryan, M., McGuirk, Griffin, F., Murphy, G. and Mahon, B., The immunology of Bordetella pertussis infection, Biologicals, 27, 1999, pp77Conference Paper, 1999
• Mills, K.H.G. , A murine model for control and new developments in pertussis vaccination, Pharmeuropa, Biological beyond 2000. Proceedings of International Conference on 'Challenge for quality standards in an evolving field', Council of Europe, Strasburg, France, 2000, pp205 - 210Conference Paper, 2000
• McGuirk P. and Mills K.H.G., Local cellular immunity to infection in the respiratry tract, Mucosal Immunology Update, 8, (2), 2000, pp8 - 10Conference Paper, 2000
• Fisch, P., Mills, K.H.G. and vanMeerwijk, J.P.M., Molecular Determinants of T cell Immunity, The Immunologist, 8, 2000, pp114 - 118Conference Paper, 2000
• P.A. Johnson, M. Conway, J. Daly, C. Nicolson J. Robertson K.H.G. Mills., Influenza HA DNA induces Th1 cells and protection despite limited antibody responses. Options for the Control of Influenza virus., International Congress Series , 1219, 2001, pp911-915Conference Paper, 2001, DOI , URL
• Mills, K.H.G. and Brady, M., Hepatitis C virus (HCV) proteins., 2003, 2003/0279Patent, 2003
• Mills, H.H.G., McGuirk, P., Keogh, B., FHA in the prophylaxis of immune mediated disorders., 2003, 2003/076Patent, 2003
• Byrne P, McGuirk P, Todryk S, Mills KHG, Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells, EUROPEAN JOURNAL OF IMMUNOLOGY, 34, (9), 2004, p2579 - 2588Journal Article, 2004, DOI , URL
• Lavelle EC, Jarnicki A, McNeela E, Armstrong ME, Higgins SC, Leavy O, Mills KHG, Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent, Journal of Leukocyte Biology, 75, (5), 2004, p756 - 763Journal Article, 2004, DOI , TARA - Full Text
• Pindjakova J, Hanley SA, Duffy MM, Sutton CE, Weidhofer GA, Miller MN, Nath KA, Mills KH, Ceredig R, Griffin MD, Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction., Kidney International, 81, (4), 2012, p379-390Journal Article, 2012, DOI , TARA - Full Text
• Allen AC, Kelly S, Basdeo SA, Kinsella K, Mulready KJ, Mills KH, Tubridy N, Walsh C, Brady JJ, Hutchinson M, Fletcher JM, A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers., Multiple sclerosis (Houndmills, Basingstoke, England), 18, (12), 2012, p1797 - 1800Journal Article, 2012, DOI
• Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM, Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance., Molecular nutrition & food research, 56, (8), 2012, p1212-1222Journal Article, 2012, DOI
• Higgs R, Higgins SC, Ross PJ, Mills KH, Immunity to the respiratory pathogen Bordetella pertussis., Mucosal immunology, 5, (5), 2012, p485-500Journal Article, 2012, DOI
• Morine MJ, Toomey S, McGillicuddy FC, Reynolds CM, Power KA, Browne JA, Loscher C, Mills KH, Roche HM, Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice., The Journal of nutritional biochemistry, 2012, p228-236Journal Article, 2012, DOI
• Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase., Clinical immunology (Orlando, Fla.), 144, (3), 2012, p228-236Journal Article, 2012, DOI
• Sutton CE, Mielke LA, Mills KH, IL-17-producing gamma delta T cells and innate lymphoid cells., European Journal of Immunology, 42, (9), 2012, p2221-2231Journal Article, 2012, DOI
• Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J, Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p4144-4153Journal Article, 2012, DOI
• Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51Journal Article, 2013, DOI , TARA - Full Text
• Jones SA, Mills KH, Harris J., Autophagy and inflammatory diseases., Immunology and Cell Biology, 91, (3), 2013, p250-258Journal Article, 2013, DOI , TARA - Full Text
• Jones, S.A., Sutton, C.E., Cua, D., Mills, K.H.G., Therapeutic potential of targeting IL-17 , Nature Immunology, 13, (11), 2012, p1022-1025Journal Article, 2012, DOI
• Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80Journal Article, 2013, DOI , TARA - Full Text
• Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264Journal Article, 2013, DOI , TARA - Full Text
• Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282Journal Article, 2013, DOI , TARA - Full Text
• Morine, M.J., Toomey, S., McGillicuddy, F.C., Reynolds, C.M., Power, K.A., Browne, J.A., Loscher, C., (...), Roche, H.M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice, Journal of Nutritional Biochemistry, 24, (5), 2013, p788-795Journal Article, 2013, DOI , TARA - Full Text
• Mills, K.H.G., Dungan, L.S., Jones, S.A., Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses, Journal of Leukocyte Biology, 93, (4), 2013, p489-497Journal Article, 2013, DOI , TARA - Full Text
• McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121Journal Article, 2014, DOI , TARA - Full Text
• Walsh, K.P., Mills, K.H.G., Dendritic cells and other innate determinants of T helper cell polarisation, Trends in Immunology, 34, (11), 2013, p521-530Journal Article, 2013, DOI
• McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM, Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice., American journal of physiology. Endocrinology and metabolism, 305, (2), 2013, pE834-E844Journal Article, 2013, DOI , TARA - Full Text
• Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH, Retinoic acid expression associates with enhanced IL-22 production by "" T cells and innate lymphoid cells and attenuation of intestinal inflammation., The Journal of experimental medicine, 210, (6), 2013, p1117-24Journal Article, 2013, DOI , TARA - Full Text
• Butt AQ, Mills KH, Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines., Oncogene, 2013Journal Article, 2013, DOI , TARA - Full Text
• Mills KH, Prior Exposure to Bacteria Attenuates Viral Disease of the Respiratory Tract: A Role for IL-17 and Innate Immune Memory?, American journal of respiratory and critical care medicine, 189, (2), 2014, p126-8Journal Article, 2014, DOI , TARA - Full Text
• Mills KH, Ross PJ, Allen AC, Wilk MM, Do we need a new vaccine to control the re-emergence of pertussis?, Trends in microbiology, 22, (2), 2014, p49-52Journal Article, 2014, DOI
• Mills KH, Gerdts V, Mouse and Pig Models for Studies of Natural and Vaccine-Induced Immunity to Bordetella pertussis., The Journal of infectious diseases, 209 Suppl 1, 2014, pS16-9Journal Article, 2014, DOI , TARA - Full Text
• Draper, Eve DeCourcey, Joseph Higgins, Sarah C. Canavan, Mary McEvoy, Fiona Lynch, Mark Keogh, Brian Reynolds, Clare Roche, Helen M. Mills, Kingston H. G. Loscher, Christine E., Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses, The Journal of Nutritional Biochemistry, 25, (7), 2014, p741-9Journal Article, 2014, TARA - Full Text
• Immunology of Multiple Sclerosis in, The Biology of Multiple Sclerosis, Cambridge University Press, 2012, pp1-146 , [Fletcher JM and Mills KHG]Book Chapter, 2012, DOI , URL
• Finlay CM, Walsh KP, Mills KH, Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases., Immunological reviews, 259, (1), 2014, p206-30Journal Article, 2014, DOI
• Raverdeau M, Mills KH, Modulation of T cell and innate immune responses by retinoic Acid., Journal of immunology (Baltimore, Md. : 1950), 192, (7), 2014, p2953-8Journal Article, 2014, DOI , TARA - Full Text
• Adkins I, Kamanova J, Kocourkova A, Svedova M, Tomala J, Janova H, Masin J, Chladkova B, Bumba L, Kovar M, Ross PJ, Tuckova L, Spisek R, Mills KH, Sebo P, Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells., PloS one, 9, (8), 2014, pe104064Journal Article, 2014, DOI , TARA - Full Text
• Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17Journal Article, 2014, DOI , URL , TARA - Full Text
• Allen AC, Mills KH, Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity., Expert review of vaccines, 13, (10), 2014, p1253-1264Journal Article, 2014, DOI
• Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708Journal Article, 2014, DOI , TARA - Full Text
• Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260Journal Article, 2015, DOI , TARA - Full Text
• Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992Journal Article, 2015, DOI
• Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH, A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine., Mucosal immunology, 8, (3), 2015, p607-617Journal Article, 2015, DOI

A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on 'the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease' is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.

• Title

  Cellular immune responses to HIV
  Summary

  Support for Postdoctoral fellow plus €13,000 for consumables costs
  Funding Agency

  Commonwealth AIDS Research Grants
  Date From

  1994
  Date To

  1995
• Title

  Role of toxin induced interlukin-1b in the neurological responses to gram negative bacteria'
  Summary

  €89,000
  Funding Agency

  Enterprise Ireland Basic research grant
  Date From

  2000
  Date To

  2004
• Title

  The role of infections agents in precipitating the neurodegenerative changes that lead to development of Alzheimer's disease.
  Summary
  Funding Agency

  TCD-UCD Innovation Alliance (joint project with Marina Lynch)
  Date From

  2010
  Date To

  2014
• Title

  New immunotherapeutics approaches based on the Th1/Th17 axis and its regulation.
  Summary
  Funding Agency

  SFI
  Date From

  2012
  Date To

  2017
• Title

  Demonstration and Shared cost projects Mucosal Vaccines - mucosal adjuvanticity of LT mutants with influenza virus antigens for intranasal immunization
  Summary

  €200,000
  Funding Agency

  EU Framework 5 Biotechnology Programme
  Date From

  2000
  Date To

  2003
• Title

  Virus variants and host immune response in the resolution and progression of chronic liver disease following Hepatitis C virus infection
  Summary

  €890,000
  Funding Agency

  Health Research Board Unit with D. Kelleher, C. O'Farrelly, W. Hall, J, Hegarty
  Date From

  1997
  Date To

  2002
• Title

  The role of T cell-derived cytokines in vaccine induced immunity against whooping cough in infants
  Summary

  €44,000
  Funding Agency

  National Institute for Health (NIH), USA
  Date From

  1996
  Date To

  1997
• Title

  Programme for Research in Third level Institutions in Ireland
  Summary

  €11.3million award to the NUI Maynooth, including €1m current costs for Immunology Research,
  Funding Agency

  Higher Education Authority
  Date From

  1999
  Date To

  2001
• Title

  The local immune response to a respiratory pathogen
  Summary

  €38,000
  Funding Agency

  Health Research Board project grant
  Date From

  1993
  Date To

  1996
• Title

  The evaluation of immunomodulators in ex-vivo models of cell based therapies and in the enhancement of efficacy of marketed biologicals
  Summary

  €372,704
  Funding Agency

  EI
  Date From

  2005
  Date To

  2007
• Title

  Chiron Corporation Fellowship 'Mechanism of adjuvant activity of E
  Summary

  €68,000
  Funding Agency

  coli heat labile toxin
  Date From

  1996
  Date To

  1999
• Title

  Mechanism of adjuvant activity of E. coli heat labile toxin
  Summary

  €68,000
  Funding Agency

  Chiron Corporation Fellowship
  Date From

  1996
  Date To

  1999
• Title

  Nasal Pandemic Influenza Vaccine (NASPANVAC)
  Summary

  €4.07m; €488,016 to TCD
  Funding Agency

  EU
  Date From

  1st May 2008
  Date To

  April 2011
• Title

  Function and regulation IL-17-secreting T cells
  Summary
  Funding Agency

  PRTLI
  Date From

  2012
  Date To

  2015
• Title

  Evaluation of biodegradable microparticles as a vaccine delivery system for an acellular pertussis vaccine
  Summary

  €305,000
  Funding Agency

  Forbairt Applied Research Award and Elan Corporation
  Date From

  1997
  Date To

  2001
• Title

  Purchase of an irradiator for inhibition of cell proliferation, induction of apoptosis and gene mutations and conditioning recipients in murine adoptive transfer experiments
  Summary

  €100,000
  Funding Agency

  Wellcome Trust Equipment award S. Martin, co-applicant
  Date To

  1997
• Title

  Modulation of immune responses by filamentous haemagglutinin from Bordetella pertussis
  Summary

  €89,000
  Funding Agency

  Health Research Board project grant
  Date From

  2000
  Date To

  2003
• Title

  Activation of innate responses by immunostimulatory sequences in bacterial DNA
  Summary

  €155,500
  Funding Agency

  Elan Corporation Student Fellowship
  Date From

  2000
  Date To

  2003
• Title

  Mucosal Vaccines for Poverty Related Diseases (MUVAPRED). FP6-2002-LIFESCIHEALTH-2.3, Proposal No 503240
  Summary

  €15m approx €350,000 to TCD
  Funding Agency

  EU 6th Framework Programme
  Date From

  2003
  Date To

  2006
• Title

  IA study of exogenous and endogenous factors that precipitate, exacerbate or regulate the T cells that cause autoimmune diseases
  Summary
  Funding Agency

  IRSCET
  Date From

  1.10.2009
  Date To

  30.9.2011
• Title

  Immunology Research Centre
  Summary

  €7.5m
  Funding Agency

  SFI
  Date From

  2008
  Date To

  2013
• Title

  Flow Cytometry Cell Sorter, €587,000.
  Summary
  Funding Agency

  SFI
  Date From

  2013
  Date To

  2015
• Title

  Genetic and immunological safety of nucleic acid vaccines
  Summary

  €220,000,
  Funding Agency

  EU Biotechnology Programme
  Date From

  1997
  Date To

  2000
• Title

  Investigations on the mechanism of immunity to B. pertussis in a murine model
  Summary

  €283,000
  Funding Agency

  Wellcome Trust project grant
  Date From

  1994
  Date To

  1997
• Title

  Biosafety of vaccines based on self-replicating recombinant alphavirus'
  Summary

  €123, 000
  Funding Agency

  EU Biotechnology Programme
  Date From

  1998
  Date To

  2000
• Title

  Nasal vaccination - a balance between beneficial immunity and neurotoxicity'
  Summary

  €152,000,
  Funding Agency

  Health Research Board Project grant
  Date From

  2001
  Date To

  2004
• Title

  The role of NOD-like receptors in inflammatory responses
  Summary

  IRCSET Enterprise Partnership Scheme Postgraduate Scholarship Award to Patrick Kelly, Co-funded by Industrial sponsor Opsona Therapeutic
  Funding Agency

  IRCSET Enterprise Partnership Scheme
  Date From

  1.10.09
  Date To

  30.9.12
• Title

  Regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human diseases
  Summary

  €3.6m
  Funding Agency

  SFI
  Date From

  2007
  Date To

  2112
• Title

  Modulation of host immune responses by effector proteins of he type III secretion system of Bordetella pertussis
  Summary

  €163,352
  Funding Agency

  IRSCET Basic Research Project
  Date From

  2002
  Date To

  2005
• Title

  Interdependence of immune mechanisms in protection against Bordetella pertussis
  Summary

  €215,000
  Funding Agency

  Wellcome Trust project grant
  Date From

  1997
  Date To

  2001
• Title

  With Prof Cliona O'Farrelly, St Vincent's Hospital (PI), Dr Dermot Kelleher, Trinity College Dublin and Dr Derek Doherty, NUI Maynooth. Characterisation of hepatitis C virus induced immunological subversion and its implications for treatment response
  Summary

  €552,000
  Funding Agency

  Health Research Board Programme Grant
  Date From

  2003
  Date To

  2006
• Title

  Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
  Summary

  €38,000
  Funding Agency

  EU Biomed-1
  Date From

  1994
  Date To

  1996
• Title

  The effect of retinoic acid on the fate of γδ T cells.
  Summary
  Funding Agency

  EU-FP7
  Date From

  2014
  Date To

  2016
• Title

  Acquisition of an automated DNA sequencer and gel documentation system for investigations on the mechanisms of programmed cell death and immunity to infectious diseases
  Summary

  €75,500
  Funding Agency

  Wellcome Trust/HRB equipment award with S. Martin
  Date To

  1997
• Title

  Regulatory T cell inducing vaccine for autoimmune diseases.
  Summary
  Funding Agency

  HRB
  Date From

  2011
  Date To

  2014
• Title

  Pathogen-derived immunomodulatory molecules - future therapeutics and vaccines
  Summary

  €6.5m
  Funding Agency

  Science Foundation Ireland Principal Investigator Award
  Date From

  2001
  Date To

  2006
• Title

  Helminth-derived immunomodulatory molecules as therapeutics for immune-mediated disease
  Summary
  Funding Agency

  SFI
  Date From

  2014
  Date To

  2015
• Title

  Neuroimmunological interactions in response to infection with a Gram negative bacterium
  Summary

  €95,000
  Funding Agency

  Forbairt Basic Research Grant
  Date From

  1997
  Date To

  2000
• Title

  T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
  Summary

  €38,000
  Funding Agency

  The Health Research Board project grant
  Date From

  1994
  Date To

  1997
• Title

  Investigations of the biochemical basis for the immunomodulatory properties of pertussis toxin
  Summary

  €25,000,
  Funding Agency

  Forbairt Basic Research Grant
  Date From

  1995
  Date To

  1997
• Title

  The role of regulatory T cells in parasite immunosuppression'
  Summary

  €163,021
  Funding Agency

  Health Research Board Postdoctoral fellowship to Dr Miriam Brady
  Date From

  2002
  Date To

  2005
• Title

  HIV nucleic acid vaccination: targeting of antigen presenting cells and induction of specific mucosal immune responses'
  Summary

  €85,000
  Funding Agency

  EU Biomed Programme
  Date From

  1997
  Date To

  2000
• Title

  The use of controlled release microparticles as oral and parenteral vaccines against Vibrio cholera, E. coli and Bordetella pertussis
  Summary

  €15,400
  Funding Agency

  EU STD Programme
  Date From

  1995
  Date To

  1997
• Title

  The role of cathepsin L cysteine proteinases secreted by helminth pathogns in modulation of immune responses
  Summary

  €76,000
  Funding Agency

  Health Research Board Postdoctoral Fellowship
  Date From

  1999
  Date To

  2000
• Title

  Purchase of a high speed cell sorter
  Summary

  €387,200.
  Funding Agency

  SFI
  Date From

  2004
• Title

  Regulatory T cell induction - an immune subversion strategy by Bordetella pertussis'
  Summary

  €149,000
  Funding Agency

  Health Research Board Postdoctoral Fellowship to Dr Peter Mc Guirk
  Date From

  2001
  Date To

  2004
• Title

  Regulation and effector function of Th1 and Th2 cells in immunity to a respiratory pathogen'
  Summary

  €38,000
  Funding Agency

  The Health Research Board Project Grant
  Date From

  1997
  Date To

  2000
• Title

  Pre-clinical evaluation of immunomodulatory molecules in the prevention or treatment of immune-mediated diseases
  Summary

  €379,646
  Funding Agency

  Enterprise Ireland
  Date From

  2004
  Date To

  2007
• Title

  Regulation of T cell responses in immunity to Bordetella pertussis
  Summary

  €209491
  Funding Agency

  HRB
  Date From

  2005
  Date To

  2008
• Title

  Activation and role of γδ T cells in mucosal immunity
  Summary
  Funding Agency

  HRB
  Date From

  10/2010
  Date To

  9/2013
• Title

  Mucosal vaccines for respiratory diseases based upon nasal administration
  Summary

  €239,000, 1996-2000.
  Funding Agency

  EU Innovation Programme
  Date From

  1996
  Date To

  2000

Immunology,

• Awarded Graves Medal and present the 39th Annual Graves Lecture 1999
• Provost Innovation award 2020
• Royal Academy of Medicine in Ireland Doctor award in Respiratory Medicine and best overall paper 2014
• Awarded fellowship by International Network of Immunology 1987
• Elected Student of the year, Wilson's Hospital, Secondary School 1972
• Inaugural Annual Award of Irish Society for Immunology 2002
• Young scientist award from International Union of Immunology Societies 1986
• Laboratory Scientist of the year and Laboratory of the year, Irish Lab awards 2013
• Merit award of rapid promotion to Senior Scientist scale 1991
• Elected to membership of the Institute of Biology of Ireland 1996
• Awarded EURATOM travelling fellowship 1977
• Elected Fellow of The Royal Academy of Medicine in Ireland 1994
• Elected to Fellowship of Trinity College Dublin 2004
• Elected to fellowship of The Royal Academy of Medicine in Ireland 1994
• SFI Researcher of the Year 2020
• Royal Irish Academy Award in Biochemistry 2004

• American Association of Immunologists
• International Society for Mucosal Immunology
• Irish Society for Immunology
• Member, Irish Area Committee of The Biochemical Society. 2001
• Irish Research Scientists Association
• Member, UK MRC Committee on Vaccines & Immunization Procedures 1995
• Institute of Biology of Ireland
• American Society for Microbiology
• Member, Irish Branch Committee of the Society for General Microbiology 1997
• British and Irish Society for General Microbiology
• Royal Academy of Medicine in Ireland
• British Society for Immunology
• Biochemical Society

• Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
• Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
• Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
• Associate Editor. The Journal of Immunology 2007-2011
• Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
• Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
• Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
• Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
• Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
• Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
• Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
• Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
• Section Editor, The Journal of Immunology 2012-present
• Section Editor, The Journal of Immunology 2012-present
• Member of Life Science Committee of Royal Irish Academy. 2003-2004
• Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
• Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
• Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
• Member of Life Science Committee of Royal Irish Academy. 2003-2004
• Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
• Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
• Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
• Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
• Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
• Member of Life Science Committee of Royal Irish Academy. 2003-2004
• Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
• Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
• Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
• Section Editor, The Journal of Immunology 2012-present
• Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
• Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
• Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
• Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
• Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
• Member expert committee on Medical Devices, Irish Medicines Board. 2001-
• Member expert committee on Medical Devices, Irish Medicines Board. 2001-
• Associate Editor. The Journal of Immunology 2007-2011
• Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
• Member of the Editorial Board. Immunology and Cell Biology 2013-
• Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013
• Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
• Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
• Member expert committee on Medical Devices, Irish Medicines Board. 2001-
• Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
• Associate Editor. The Journal of Immunology 2007-2011
• Member of the Editorial Board. Immunology and Cell Biology 2013-
• Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
• Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
• Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
• Member of the Editorial Board. Immunology and Cell Biology 2013-
• Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
• Member of the Editorial Board. Immunology and Cell Biology 2013-
• Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
• Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
• Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
• Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997
• Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
• Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000
• Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
• Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000
• Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
• Section Editor, The Journal of Immunology 2012-present
• Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998
• Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-
• Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
• Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003
• Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013
• Member, WHO International Committee on DNA Vaccines. 1996-2000
• Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
• Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
• Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-
• Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
• Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001
• Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
• Member, Infection & Immunity Committee of British Society for Immunology. 1998-present
• Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
• Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
• Member of Life Science Committee of Royal Irish Academy. 2003-2004
• Member, WHO International Committee on DNA Vaccines. 1996-2000
• Associate Editor. The Journal of Immunology 2007-2011
• Member expert committee on Medical Devices, Irish Medicines Board. 2001-
• Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006
• Member, WHO International Committee on DNA Vaccines. 1996-2000
• Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
• Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003
• Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
• Member, WHO International Committee on DNA Vaccines. 1996-2000
• Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002
• Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-
• Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001
• Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004
• Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997