Dr. Rachel Mary Mc Loughlin

• Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, TRAM is required for TLR2 endosomal signaling to type I IFN induction., Journal of immunology (Baltimore, Md. : 1950), 193, (12), 2014, p6090-102Journal Article, 2014, DOI , TARA - Full Text
• O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445-Journal Article, 2015, DOI , TARA - Full Text
• Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226Journal Article, 2015, DOI , TARA - Full Text
• The importance of cell mediated immunity for bacterial vaccines in, Vaccine Design: Innovative Approaches and Novel Strategies, Caister Academic Press, 2015, pp220 - 249, [Alison G.Murphy & Rachel M. McLoughlin]Book Chapter, 2015, DOI
• Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22-Journal Article, 2016, DOI , TARA - Full Text
• Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441Journal Article, 2016, DOI , URL , TARA - Full Text
• Stojkovic B, Mullen M.P, Donofrio G, McLoughlin R.M, Meade K.G, Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle, Veterinary Immunology and Immunopathology, 184, 2017, p18 - 28Journal Article, 2017, DOI , URL
• Stojkovic B, McLoughlin R.M, Meade K.G, In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves, Veterinary Immunology and Immunopathology, 182, 2016, p1 - 10Journal Article, 2016, DOI , URL
• Mulcahy M.E, McLoughlin R.M, Hostâ€"Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization, Trends in Microbiology, 24, (11), 2016, p872 - 886Journal Article, 2016, DOI , URL
• Lalor S.J, McLoughlin R.M, Memory γÎ" T Cellsâ€"Newly Appreciated Protagonists in Infection and Immunity, Trends in Immunology, 37, (10), 2016, p690 - 702Journal Article, 2016, DOI , URL
• Mulcahy M.E, McLoughlin R.M, Staphylococcus aureus and influenza a virus: Partners in coinfection, mBio, 7, (6), 2016, e02068-16Journal Article, 2016, DOI , URL , TARA - Full Text
• Weidenmaier C, McLoughlin R.M, Lee J.C, The Zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism, PLoS ONE, 5, (10), 2010Journal Article, 2010, DOI , URL
• Hurst S.M, Wilkinson T.S, McLoughlin R.M, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller G.M, Topley N, Jones S.A, IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation, Immunity, 14, (6), 2001, p705 - 714Journal Article, 2001, DOI , URL
• Leech JM, Lacey KA, Mulcahy ME, Medina E, McLoughlin RM, IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections., 198, (6), 2017, p2352-2365Journal Article, 2017, DOI , URL , TARA - Full Text
• Zaslona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LA., The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma., American Journal of Physiology Lung Cellular and Molecular Physiology, 2017, pL855-L860Journal Article, 2017, DOI
• Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17-Journal Article, 2017, TARA - Full Text
• Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 -Journal Article, 2017, DOI , URL
• Rudkin, J.K. and McLoughlin, R.M. and Preston, A. and Massey, R.C., Bacterial toxins: Offensive, defensive, or something else altogether?, PLoS Pathogens, 13, (9), 2017, e1006452.-Journal Article, 2017, DOI , URL , TARA - Full Text
• Clowry, J., Irvine, A.D., McLoughlin, R.M., Next-generation anti"Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?, Journal of Allergy and Clinical Immunology, 143, (1), 2019, p78-81Journal Article, 2019, DOI , TARA - Full Text
• Lacey K.A, Mulcahy M.E, Towell A.M, Geoghegan J.A, McLoughlin R.M, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLoS pathogens, 15, (4), 2019, pe1007713-Journal Article, 2019, DOI , TARA - Full Text
• O'Brien E.C, McLoughlin R.M, Considering the â€~Alternatives†for Next-Generation Anti-Staphylococcus aureus Vaccine Development, Trends in Molecular Medicine, 25, (3), 2019, p171 - 184Journal Article, 2019, DOI
• Connolly R, Denton M.D, Humphreys H, McLoughlin R.M, Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?, Kidney International, 95, (3), 2019, p518 - 525Journal Article, 2019, DOI , TARA - Full Text
• Edwards, S.C. and Sutton, C.E. and Ladell, K. and Grant, E.J. and McLaren, J.E. and Roche, F. and Dash, P. and Apiwattanakul, N. and Awad, W. and Miners, K.L. and Lalor, S.J. and Ribot, J.C. and Baik, S. and Moran, B. and McGinley, A. and Pivorunas, V. and Dowding, L. and Macoritto, M. and Paez-Cortez, J. and Slavin, A. and Anderson, G. and Silva-Santos, B. and Hokamp, K. and Price, D.A. and Thomas, P.G. and McLoughlin, R.M. and Mills, K.H.G., A population of proinflammatory T cells coexpresses αβ and γΎ T cell receptors in mice and humans, Journal of Experimental Medicine, 217, (5), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236Journal Article, 2022
• Megan B. O"Brien, Charlotte L. Beynon, Rachel M. McLoughlin, Kieran G. Meade, The immune response in bovine primary dermal fibroblasts is influenced by Interleukin 8 promoter haplotype and vitamin D, Veterinary Immunology and Immunopathology, 238, 2021, p110291Journal Article, 2021
• Clegg J, Soldaini E, McLoughlin RM, Rittenhouse S, Bagnoli F, Phogat S, Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies., Frontiers in immunology, 2021Journal Article, 2021
• O'Brien MB, McLoughlin RM, Roche C, Nelson CD, Meade KG, Effect of IL-8 haplotype on temporal profile in circulating concentrations of interleukin 8 and 25(OH) vitamin D in Holstein-Friesian calves., Veterinary immunology and immunopathology, 2021Journal Article, 2021
• Vozza EG, Mulcahy ME, McLoughlin RM, Making the Most of the Host; Targeting the Autophagy Pathway Facilitates Staphylococcus aureus Intracellular Survival in Neutrophils., Frontiers in immunology, 2021Journal Article, 2021
• Fox PG, Schiavetti F, Rappuoli R, McLoughlin RM, Bagnoli F, Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins., mBio, 2021Journal Article, 2021
• Cooper AJR, Clegg J, Cassidy FC, Hogan AE, McLoughlin RM., Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity., Microorganisms, 10, (1), 2022Journal Article, 2022, DOI
• Clegg J, Soldaini E, Bagnoli F, McLoughlin RM, Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections., Trends in immunology, 2020Journal Article, 2020
• Mulcahy ME, O'Brien EC, O'Keeffe KM, Vozza EG, Leddy N, McLoughlin RM, Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils., Frontiers in immunology, 2020Journal Article, 2020
• Duggan S, Laabei M, Alnahari AA, O'Brien EC, Lacey KA, Bacon L, Heesom K, Fu CL, Otto M, Skaar E, McLoughlin RM, Massey RC, A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus., Infection and immunity, 2020Journal Article, 2020
• Cooper AJR, Lalor SJ, McLoughlin RM, Activation of Human V"2⁺ "" T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity., Journal of immunology (Baltimore, Md. : 1950), 2020Journal Article, 2020
• Kelly AM, McLoughlin RM, Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection., Frontiers in immunology, 2020Journal Article, 2020
• O'Brien MB, McLoughlin RM, Meade KG, Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle., Veterinary immunology and immunopathology, 2020Journal Article, 2020
• Immune Response to Staphylococcus aureus in, Staphylococcus: Genetics and Physiology., Caister Academic Press, 2016, pp335--388 , [Aisling F. Brown, Rachel M. McLoughlin]Book Chapter, 2016
• Mannion JM, McLoughlin RM, Lalor SJ, The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease, Clinical Reviews in Allergy & Immunology,, March 11, 2022Journal Article, 2022, DOI
• Kelly, A.M. and Leech, J.M. and Doyle, S.L. and McLoughlin, R.M., Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation, PLoS Pathogens, 18, (7), 2022Journal Article, 2022, DOI
• Curham, L.M. and Mannion, J.M. and Daly, C.M. and Wilk, M.M. and Borkner, L. and Lalor, S.J. and McLoughlin, R.M. and Mills, K.H.G., Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae, European Journal of Immunology, 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Baran, M. and Feriotti, C. and McGinley, A. and Carlile, S.R. and Jiang, Z. and Calderon-Gonzalez, R. and Dumigan, A. and Sá-Pessoa, J. and Sutton, C.E. and Kearney, J. and McLoughlin, R.M. and Mills, K.H.G. and Fitzgerald, K.A. and Bengeochea, J.A. and Bowie, A.G., PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection, Cell Reports, 42, (4), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and O†Brien, E.C. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and O†Donnell, J.S. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and O†Neill, L.A.J., Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (Nature Communications, (2023), 14, 1, (3513), 10.1038/s41467-023-39174-1), Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and Brien, E.C.O. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and Donnell, J.S.O. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and Neill, L.A.J.O., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon, Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Clowry Juliann, Dempsey Daniel J, Claxton Tracey J, Towell Aisling M, Turley Mary B, Sutton Marti, Geoghegan Joan A, Kezic Sanj, Jakasa Ivon, White Arthu, Irvine Alan D, McLoughlin Rachel M, Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis, 9, (9), 2024, p1-19Journal Article, 2024, DOI
• Kelly AM, McCarthy KN, Claxton TJ, Carlile SR, O'Brien EC, Vozza EG, Mills KH, McLoughlin RM., IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection., JCI insight, 9, (13), 2024, pe178216Journal Article, 2024, DOI
• Vozza EG, Daly CM, O'Rourke SA, Fitzgerald HK, Dunne A, McLoughlin RM., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival., mBio : Duplicate, marked for deletion, 15, (1), 2024, pe0257123Journal Article, 2024, DOI
• McCarthy KN, Hone S, McLoughlin RM, Mills KHG., IL-17 and IFN-"-producing respiratory tissue resident memory CD4"T cells persist for decades in adults immunized as children with whole cell pertussis vaccines., The Journal of infectious diseases, 2024, pjiae034Journal Article, 2024, DOI
• Douglas EJA, Palk N, Brignoli T, Altwiley D, Boura M, Laabei M, Recker M, Cheung GYC, Liu R, Hsieh RC, Otto M, O'Brien E, McLoughlin RM, Massey RC., Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia., eLife, 12, 2023, pRP87026Journal Article, 2023, DOI
• Mannion JM, Segal BM, McLoughlin RM, Lalor SJ., Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells., Mucosal immunology, 16, (4), 2023, p399-407Journal Article, 2023, DOI
• Ward J, Zhang S, Sikora A, Michalski R, Yin Y, D'Alessio A, McLoughlin RM, Jaquet V, Fieschi F, Knaus UG., VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity., Redox biology, 67, 2023, p102905Journal Article, 2023, DOI
• Stevens E.J., Morse D.J., Bonini D., Duggan S., Brignoli T., Recker M., Lees J.A., Croucher N.J., Bentley S., Wilson D.J., Earle S.G., Dixon R., Nobbs A., Jenkinson H., van Opijnen T., Thibault D., Wilkinson O.J., Dillingham M.S., Carlile S., McLoughlin R.M., Massey R.C., Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae, Microbial Genomics, 8, (4), 2022Journal Article, 2022, DOI
• Ultán P. Doherty, Rachel McLoughlin, Tracey Claxton, Arthur White, gateTree: A user-informed tree algorithm for population identification in flow cytometry, International Workshop on Statistical Modelling 2024, Durham, United Kingdom, 14 to 19 July 2024, edited by Jochen Einbeck, Reza Drikvandi, Georgios Karagiannis, Konstantinos Perrakis, Qing Zhang , 2024, pp108 - 113Conference Paper, 2024, URL
• Vozza, E.G. and Kelly, A.M. and Daly, C.M. and O†Rourke, S.A. and Carlile, S.R. and Morris, B. and Dunne, A. and McLoughlin, R.M., Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis, Cell Death Discovery, 10, (1), 2024Journal Article, 2024, DOI , URL
• Vozza, E.G. and Daly, C.M. and O'Rourke, S.A. and Fitzgerald, H.K. and Dunne, A. and McLoughlin, R.M., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival, mBio, 15, (1), 2024Journal Article, 2024, DOI , URL
• Carlile, S.R. and Cahill, S.C. and O'Brien, E.C. and Neto, N.G.B. and Monaghan, M.G. and McLoughlin, R.M., Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection, iScience, 27, (12), 2024Journal Article, 2024, DOI , URL
• Doherty, Ultán P. and McLoughlin, Rachel M. and White, Arthur, Challenges and Adaptations of Model-Based Clustering for Flow and Mass Cytometry, WIREs Computational Statistics, 17, (1), 2025, p1 - 15Journal Article, 2025, DOI , TARA - Full Text
• McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191Journal Article, 2010, DOI , URL , TARA - Full Text
• McLoughlin, R.M., Mills, K.H.G., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma, Journal of Allergy and Clinical Immunology, 127, (5), 2011, p1097-1107Journal Article, 2011, DOI
• Cohen-Poradosu R, McLoughlin RM, Lee JC, Kasper DL, Bacteroides fragilis-stimulated interleukin-10 contains expanding disease., The Journal of infectious diseases, 204, (3), 2011, p363-71Journal Article, 2011, DOI
• Lee JC, Greenwich JL, Zhanel GG, Han X, Cumming A, Saward L, McLoughlin RM, Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection., Infection and immunity, 78, (10), 2010, p4176-86Journal Article, 2010
• Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA, Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells., Journal of immunology (Baltimore, Md. : 1950), 184, (4), 2010, p2130-9Journal Article, 2010
• Ni J, McLoughlin RM, Brodovitch A, Moulin P, Brouckaert P, Casadei B, Feron O, Topley N, Balligand JL, Devuyst O, Nitric oxide synthase isoforms play distinct roles during acute peritonitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25, (1), 2010, p86-96Journal Article, 2010
• Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE, Characterization of regulatory T cells in urban newborns., Clinical and molecular allergy : CMA, 7, 2009, p8Journal Article, 2009
• Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ, IL-6 regulates neutrophil trafficking during acute inflammation via STAT3., Journal of immunology (Baltimore, Md. : 1950), 181, (3), 2008, p2189-95Journal Article, 2008
• McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO, IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection., Journal of immunology (Baltimore, Md. : 1950), 181, (2), 2008, p1323-32Journal Article, 2008
• Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL, A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2., The Journal of experimental medicine, 203, (13), 2006, p2853-63Journal Article, 2006
• McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC, CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections., Proceedings of the National Academy of Sciences of the United States of America, 103, (27), 2006, p10408-13Journal Article, 2006
• Ni J, Cnops Y, McLoughlin RM, Topley N, Devuyst O, Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 25 Suppl 3, 2005, pS11-4Journal Article, 2005
• Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA, Viral IL-6 blocks neutrophil infiltration during acute inflammation., Journal of immunology (Baltimore, Md. : 1950), 175, (6), 2005, p4024-9Journal Article, 2005
• Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO, Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection., Antimicrobial agents and chemotherapy, 50, (11), 2006, p3856-60Journal Article, 2006
• Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA, Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis., Arthritis and rheumatism, 54, (5), 2006, p1662-72Journal Article, 2006
• Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M, Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling., Nature medicine, 11, (8), 2005, p845-52Journal Article, 2005
• McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA, IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation., Proceedings of the National Academy of Sciences of the United States of America, 102, (27), 2005, p9589-94Journal Article, 2005
• McLoughlin RM, Hurst SM, Nowell MA, Harris DA, Horiuchi S, Morgan LW, Wilkinson TS, Yamamoto N, Topley N, Jones SA, Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms., Journal of immunology (Baltimore, Md. : 1950), 172, (9), 2004, p5676-83Journal Article, 2004
• McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N, Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation., The Journal of clinical investigation, 112, (4), 2003, p598-607Journal Article, 2003
• Mortier S, De Vriese AS, McLoughlin RM, Topley N, Schaub TP, Passlick-Deetjen J, Lameire NH, Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane., Journal of the American Society of Nephrology : JASN, 14, (5), 2003, p1296-306Journal Article, 2003
• Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA, Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells., Journal of immunology (Baltimore, Md. : 1950), 169, (9), 2002, p5244-51Journal Article, 2002
• Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM, Giddings JC, Lewis MJ, Haslam RJ, Freeman BA, O'Donnell VB, Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP., The Journal of biological chemistry, 277, (8), 2002, p5832-40Journal Article, 2002
• Robson RL, McLoughlin RM, Witowski J, Loetscher P, Wilkinson TS, Jones SA, Topley N, Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo., Journal of immunology (Baltimore, Md. : 1950), 167, (2), 2001, p1028-38Journal Article, 2001
• Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M, Gergen P, Gold DR, Witter F, Chen T, Holick M, Visness C, Gern J, O'Connor GT, Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 41, (6), 2011, p842-50Journal Article, 2011
• McLoughlin RM, Topley, N, Switching on EMT in the peritoneal membrane: considering the evidence., Nephrology Dialysis and Transplant, 26, (1), 2011, p12 - 15Journal Article, 2011
• McLoughlin RM, Resolving peritoneal inflammation :Flicking the right "switches". , Peritoneal Dialysis International, 25, 2005, p223 - 229Journal Article, 2005
• Davenport A, Li F, Robson R, Wilkinson TS, McLoughlin RM, Topley N. , Early Peritoneal Responses to Bacterial Invasion: Cellular Exudation, Sepsis, 3, (4), 1999, p303-Journal Article, 1999
• Immunomodulation by zwitterionic polysaccharides in, Microbial Glycobiology: Structure, Relevance and Applications, Elsevier, 2009, [McLoughlin RM, Kasper DL]Book Chapter, 2009
• McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR, Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 42, (3), 2012, p392-404Journal Article, 2012, DOI
• Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092Journal Article, 2012, DOI , TARA - Full Text
• Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264Journal Article, 2013, DOI , TARA - Full Text
• Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489Journal Article, 2013, DOI
• Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484Journal Article, 2014, DOI , TARA - Full Text
• Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design., Frontiers in immunology, 4, 2014, p507Journal Article, 2014, DOI , TARA - Full Text
• Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA, Interleukin-6 signaling drives fibrosis in unresolved inflammation., Immunity, 40, (1), 2014, p40-50Journal Article, 2014, DOI
• Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708Journal Article, 2014, DOI , TARA - Full Text
• Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus colonization: modulation of host immune response and impact on vaccine design, Frontiers in Immunology, 4, 2014, p507-Journal Article, 2014, TARA - Full Text

• Title

  Profiling immune signatures predictive of outcome in Staphylococcus aureus infection: Advancing next-generation vaccine design
  Summary

  15/IA/3041
  Funding Agency

  Science Foundation Ireland
  Date From

  01/09/16
  Date To

  31/08/20
• Title

  " A role for the immunomodulatory capsular polysaccharide Sp1 expressed by Streptococcus pneumoniae in the treatment of Asthma (PIRG06-GA-2009-256378)
  Summary

  This proposal will investigate the immunomodulatory properties of a capsular polysaccharide molecule expressed by the organism Streptococcus pneumoniae, which is commonly found to colonise the nasopharynx. This molecule has been shown to possess a unique chemical structure that confers upon it the ability to activate immunomodulatroy T-cells to produce the anti-inflammatory cytokine Interleukin-10. We will now investigate the ability of this polysaccharide to induce IL-10 production and protect against experimental asthma.
  Funding Agency

  European Commission
  Date From

  01/10/10
  Date To

  30/9/14
• Title

  Immunomodulation by the pathobiont Staphylococcus aureus: benefits for bug or host
  Summary

  CS/2014/1150/E
  Funding Agency

  Enterprise Ireland
  Date From

  01/12/14
  Date To

  31/12/15
• Title

  Targeting cellular immunity; the future for Staphylococcus aureus vaccine design
  Summary

  HRA_POR/2012/104
  Funding Agency

  Health Research Board
  Date From

  01/10/12
  Date To

  30/09/15
• Title

  Skin delivery and tissue-resident T cell responses: implications for innovative vaccines
  Summary
  Funding Agency

  GlaxoSmithKline
  Date From

  2021
  Date To

  2025
• Title

  Conference grant to support Staph GBI
  Summary

  13/CW/B2624
  Funding Agency

  Science Foundation Ireland
  Date From

  01/08/13
  Date To

  31/01/14
• Title

  Understanding cellular immunity to Staphylococcus aureus is required for novel anti-S.aureus vaccine design
  Summary

  12/IP/1532
  Funding Agency

  Science Foundation Ireland
  Date From

  01/04/13
  Date To

  31/03/17
• Title

  Staphylococcus aureus induced immunosuppressive memory: consequences for bug and for host
  Summary

  202846/Z/16/Z
  Funding Agency

  Wellcome Trust
  Date From

  01/09/17
  Date To

  31/08/21
• Title

  Investigating the link between IL8 haplotype and susceptibility to bacterial and viral infection in calves
  Summary

  201603
  Funding Agency

  Teagasc
  Date From

  01/10/16
  Date To

  30/09/20
• Title

  Vaccination:Knowledge is Power
  Summary
  Funding Agency

  Health Research Board
  Date From

  2018
  Date To

  2022
• Title

  Characterisation and exploitation of skin resident memory CD4 T cells for novel vaccines for Staphylococcus aureus
  Summary
  Funding Agency

  GlaxoSmithKline
  Date From

  2019
  Date To

  2024
• Title

  Delineating immune memory to Staphylococcus aureus
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  2018
  Date To

  2022
• Title

  Regulation of the neutrophil response by T-cell derived cytokines impacts upon Staphylococcus aureus infection outcomes (WT086515MA)
  Summary

  This proposal investigates how T-cells activated in the context of acute S.aureus infection can modulate the local neutrophil response. A clinically relevant murine model of S. aureus wound infection will be employed in conjunction with knockout mice to establish if specific T-cell phenotypes present at sites of S.aureus infection and the cytokines they produce can control neutrophil trafficking, activation and survival. The major focus of this grant is the neutrophil response during S.aureus infection. In particular it will investigate the controversial concept that S.aureus can exploit the neutrophil response and survive intra-cellular within the neutrophil. The conditions that favor this phenomena and the mechanism involved will be determined e.g. rate of neutrophil apoptosis/necrosis, phagocytic activity, and authophagy. In particular we will investigate if T-cell derived cytokines can modulate these phenomena.
  Funding Agency

  Wellcome Trust
  Date From

  17/01/10
  Date To

  16/01/15
• Title

  Characterisation of epithelial surface immunity to Staphylococcus aureus: Targeting IL-22
  Summary

  GOIPD/2014/385
  Funding Agency

  Irish Research Council
  Date From

  01/10/14
  Date To

  30/09/16
• Title

  Comparative analysis of blood, milk and uterine neutrophil function in primiparous and multiparous Holstein-Friesian cows with divergent immunity genotypes
  Summary

  GO1535
  Funding Agency

  Teagasc
  Date From

  01/10/11
  Date To

  30/09/15
• Title

  Characterisation of Staphylococcal protein A - Bcell interactions to facilitate its development as a vaccine antigen
  Summary
  Funding Agency

  GSK
  Date From

  01/10/15
  Date To

  30/09/19

Immunology,

• Panel Member St Brigid's Day Event, Irish Embassy London: Celebrating the creativity of Irish women 2018
• Science Foundation Ireland Early Career Researcher of the Year 2017
• TCD Faculty of STEM Award for excellence in postgraduate research supervision 2023
• Elected to Fellowship Trinity College Dublin 2016

• International Cytokine Society to date
• American Association of Microbiology 2013
• American Association of Immunology 2013
• Irish Society of Immunology to date
• Infectious Diseases Society of America 2009
• British Society Immunology to date

• Editorial board member Infection and Immunity 2019
• Associate editor PLOS Pathogens. 2020
• Associate editor PLOS Pathogens. 2020
• Member of the Welcome Immune System in Health and Disease Expert Review Group 2020
• Member of the Welcome Immune System in Health and Disease Expert Review Group 2020
• Editorial board member Infection and Immunity 2019