Trinity Biomedical Sciences Institute

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152-160 Pearse Street
Trinity College Dublin
Dublin 2
Ireland

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Professor Martin Caffrey

Professor Martin Caffrey

Fellow Emeritus, Biochemistry

Fellow Emeritus, School Office - Medicine

Publications and Further Research Outputs

  • Caffrey, M., A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes, Acta Crystallographica Section F Structural Biology Communications, 71, 2015, p3 - 18Journal Article, 2015, DOI , URL , TARA - Full Text
  • Li, D. Pye, V.E. Caffrey, M., Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method, Acta Crystallographica Section D Biological Crystallography, 71, 2015, p104 - 122Journal Article, 2015, DOI , URL , TARA - Full Text
  • Takeda, H. Hattori, M. Nishizawa, T. Yamashita, K. Shah, S.T.A. Caffrey, M. Maturana, A.D. Ishitani, R. Nureki, O., Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE, Nature Communications, 5, 2014, p5374-Journal Article, 2014, DOI , URL , TARA - Full Text
  • Li, D. Caffrey, M., Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic, Scientific Reports, 4, 2014, p5806-Journal Article, 2014, DOI , URL , TARA - Full Text
  • Boland, C. Li, D. Shah, S.T.A. Haberstock, S. Dötsch, V. Bernhard, F. Caffrey, M., Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination, Cellular and molecular life sciences : CMLS71, 24, 2014, p4895-4910Journal Article, 2014, DOI , URL , TARA - Full Text
  • Caffrey, M. Eifert, R. Li, D. Howe, N., The lipid cubic phase or in meso method for crystallizing proteins. Bushings for better manual dispensing, Journal of Applied Crystallography, 47, (5), 2014, p1804 - 1806Journal Article, 2014, DOI , URL , TARA - Full Text
  • Lyons, J.A. Parker, J.L. Solcan, N. Brinth, A. Li, D. Shah, S.T. Caffrey, M. Newstead, S., Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters, EMBO Reports, 15, (8), 2014, p886 - 893Journal Article, 2014, DOI , URL , TARA - Full Text
  • Nji, E. Li, D. Doyle, D.A. Caffrey, M., Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa, Acta Crystallographica Section F Structural Biology Communications, 70, 2014, p1362 - 1367Journal Article, 2014, DOI , URL , TARA - Full Text
  • Tan, J. Rouse, S.L. Li, D. Pye, V.E. Vogeley, L. Brinth, A.R. El Arnaout, T. Whitney, J.C. Howell, P.L. Sansom, M.S.P. Caffrey, M., A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa, Acta Crystallographica Section D Biological Crystallography, 70, (8), 2014, p2054 - 2068Journal Article, 2014, DOI , URL , TARA - Full Text
  • Caffrey, M., Li, D., Howe, N., Shah, S.T.A., Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase, Philosophical Transactions of the Royal Society B: Biological Sciences, 369, (1647), 2014, 20130621-Journal Article, 2014, DOI , TARA - Full Text
  • Kang Y, Zhou X.E, Gao X, He Y, Liu W, Ishchenko A, Barty A, White T.A, Yefanov O, Han G.W, Xu Q, De Waal P.W, Ke J, Tan M.H.E, Zhang C, Moeller A, West G.M, Pascal B.D, Van Eps N, Caro L.N, Vishnivetskiy S.A, Lee R.J, Suino-Powell K.M, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams G.J, Messerschmidt M, Gati C, Zatsepin N.A, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad C.E, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter C.S, Carragher B, Caffrey M, Jiang H, Chapman H.N, Spence J.C.H, Fromme P, Weierstall U, Ernst O.P, Katritch V, Gurevich V.V, Griffin P.R, Hubbell W.L, Stevens R.C, Cherezov V, Melcher K, Xu H.E, Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, Nature, 523, (7562), 2015, p561 - 567Journal Article, 2015, DOI , URL
  • Stansfeld P.J, Goose J.E, Caffrey M, Carpenter E.P, Parker J.L, Newstead S, Sansom M.S.P, MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes, Structure, 23, (7), 2015, p1350 - 1361Journal Article, 2015, DOI , URL , TARA - Full Text
  • Fowler P.W, Orwick-Rydmark M, Radestock S, Solcan N, Dijkman P.M, Lyons J.A, Kwok J, Caffrey M, Watts A, Forrest L.R, Newstead S, Gating topology of the proton-coupled oligopeptide symporters, Structure, 23, (2), 2015, p290 - 301Journal Article, 2015, DOI , URL , TARA - Full Text
  • Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota A.E, Surana P, Kottur J, Nair D.T, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang B.-C, Steinmetz M.O, Caffrey M, Wang M, Erratum: Fast native-SAD phasing for routine macromolecular structure determination (Nature Methods (2015) 12 (131-133)), Nature Methods, 12, (7), 2015, p692-Journal Article, 2015, DOI , URL
  • Huang C.-Y, Olieric V, Ma P, Panepucci E, Diederichs K, Wang M, Caffrey M, In meso in situ serial X-ray crystallography of soluble and membrane proteins, Acta Crystallographica Section D: Biological Crystallography, 71, 2015, p1238 - 1256Journal Article, 2015, DOI , URL , TARA - Full Text
  • Weinert T, Olieric V, Waltersperger S, Panepucci E, Chen L, Zhang H, Zhou D, Rose J, Ebihara A, Kuramitsu S, Li D, Howe N, Schnapp G, Pautsch A, Bargsten K, Prota A.E, Surana P, Kottur J, Nair D.T, Basilico F, Cecatiello V, Pasqualato S, Boland A, Weichenrieder O, Wang B.-C, Steinmetz M.O, Caffrey M, Wang M, Fast native-SAD phasing for routine macromolecular structure determination, Nature Methods, 12, (2), 2015, p131 - 133Journal Article, 2015, DOI , URL
  • Ghachi M.E, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez J.-C, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F, Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis, Cellular and Molecular Life Sciences, 74, (12), 2017, p2319-2332Journal Article, 2017, DOI , URL
  • Rues R.-B, Henrich E, Boland C, Caffrey M, Bernhard F, Cell-free production of membrane proteins in escherichia coli lysates for functional and structural studies, Protocol Heterologous Expression of Membrane Proteins, 1432, 2016, p1-21Journal Article, 2016, DOI , URL
  • Zhou X.E, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White T.A, Yefanov O, Han G.W, Xu Q, De Waal P.W, Suino-Powell K.M, Boutet S, Williams G.J, Wang M, Li D, Caffrey M, Chapman H.N, Spence J.C.H, Fromme P, Weierstall U, Stevens R.C, Cherezov V, Melcher K, Xu H.E, X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, Scientific Data, 3, 2016, p21-Journal Article, 2016, DOI , URL , TARA - Full Text
  • Vogeley L, El Arnaout T, Bailey J, Stansfeld P.J, Boland C, Caffrey M, Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin, Science, 351, (6275), 2016, p876 - 880Journal Article, 2016, DOI , URL
  • Wojdyla J.A, Panepucci E, Martiel I, Ebner S, Huang C.-Y, Caffrey M, Bunk O, Wang M, Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals, Journal of Applied Crystallography, 49, 2016, p944 - 952Journal Article, 2016, DOI , URL , TARA - Full Text
  • Huang C.Y, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M, In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures, Acta crystallographica. Section D, Structural biology, 72, 2016, p93 - 112Journal Article, 2016, DOI , URL , TARA - Full Text
  • Olieric V, Weinert T, Finke A.D, Anders C, Li D, Olieric N, Borca C.N, Steinmetz M.O, Caffrey M, Jinek M, Wang M, Data-collection strategy for challenging native SAD phasing, Acta Crystallographica Section D: Structural Biology, 72, (3), 2016, p421 - 429Journal Article, 2016, DOI , URL , TARA - Full Text
  • Li D, Stansfeld P.J, Sansom M.S.P, Keogh A, Vogeley L, Howe N, Lyons J.A, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, Zatsepin N.A, Cherezov V, Liu W, Bandaru S, English N.J, Gati C, Barty A, Yefanov O, Chapman H.N, Diederichs K, Messerschmidt M, Boutet S, Williams G.J, Seibert M.M, Caffrey M, Ternary structure reveals mechanism of a membrane diacylglycerol kinase, Nature Communications, 6, 2015, p10140-Journal Article, 2015, DOI , URL , TARA - Full Text
  • Caffrey M, Li D, Howe N, Shah S.T.A, 'Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase, Philosophical Transactions of the Royal Society B: Biological Sciences, 369, (1647), 2014Journal Article, 2014, DOI , URL
  • Parker, J.L. and Li, C. and Brinth, A. and Wang, Z. and Vogeley, L. and Solcan, N. and Ledderboge-Vucinic, G. and Swanson, J.M.J. and Caffrey, M. and Voth, G.A. and Newstead, S., Proton movement and coupling in the POT family of peptide transporters, Proceedings of the National Academy of Sciences of the United States of America, 114, (50), 2017, p13182-13187Journal Article, 2017, DOI , URL
  • Ma, P. and Weichert, D. and Aleksandrov, L.A. and Jensen, T.J. and Riordan, J.R. and Liu, X. and Kobilka, B.K. and Caffrey, M., The cubicon method for concentrating membrane proteins in the cubic mesophase, Nature Protocols, 12, (9), 2017, p1745-1762Journal Article, 2017, DOI , URL
  • Caffrey, M. and Drew, D., Editorial overview: Membranes, Current Opinion in Structural Biology, 45, 2017, pvii-ixJournal Article, 2017, DOI , URL
  • Wiktor, M. and Weichert, D. and Howe, N. and Huang, C.-Y. and Olieric, V. and Boland, C. and Bailey, J. and Vogeley, L. and Stansfeld, P.J. and Buddelmeijer, N. and Wang, M. and Caffrey, M., Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis, Nature Communications, 8, 2017, p15952-Journal Article, 2017, DOI , URL , TARA - Full Text
  • Höfer, N., Aragão, D., Caffrey, M. , The lipidic cubic phase as a membrane mimetic, Biophysical Journal , 100, (8), 2011, p2075 -Journal Article, 2011, TARA - Full Text
  • Ravelli, R.B.G. and Leiros, H.-K.S. and Pan, B. and Caffrey, M. and McSweeney, S., Specific radiation damage can be used to solve macromolecular crystal structures, Structure, 11, (2), 2003, p217-224Journal Article, 2003, DOI , URL
  • Cherezov, V. and Clogston, J. and Misquitta, Y. and Abdel-Gawad, W. and Caffrey, M., Membrane protein crystallization in meso: Lipid type-tailoring of the cubic phase, Biophysical Journal, 83, (6), 2002, p3393-3407Journal Article, 2002, DOI , URL
  • Brzustowicz, M.R. and Cherezov, V. and Caffrey, M. and Stillwell, W. and Wassall, S.R., Molecular organization of cholesterol in polyunsaturated membranes: Microdomain formation, Biophysical Journal, 82, (1), 2002, p285-298Journal Article, 2002, DOI , URL
  • Cherezov, V. and Qiu, H. and Pector, V. and Vandenbranden, M. and Ruysschaert, J.-M. and Caffrey, M., Biophysical and transfection studies of the diC14-amidine/DNA complex, Biophysical Journal, 82, (6), 2002, p3105-3117Journal Article, 2002, DOI , URL
  • Koynova, R. and Caffrey, M., Erratum: Phases and phase transitions of the phosphatidylcholines (Biochimica et Biophysica Acta (1998) 1376 (91-145) PII: S0304415798000069), Biochimica et Biophysica Acta - Biomembranes, 1513, (1), 2001, p82Journal Article, 2001, DOI , URL
  • Misquitta, Y. and Caffrey, M., Rational design of lipid molecular structure: A case study involving the C19:1c10 monoacylglycerol, Biophysical Journal, 81, (2), 2001, p1047-1058Journal Article, 2001, DOI , URL
  • Cherezov, V. and Fersi, H. and Caffrey, M., Crystallization screens: Compatibility with the lipidic cubic phase for in meso crystallization of membrane proteins, Biophysical Journal, 81, (1), 2001, p225-242Journal Article, 2001, DOI , URL
  • Ai, X. and Caffrey, M., Membrane protein crystallization in lipidic mesophases: Detergent effects, Biophysical Journal, 79, (1), 2000, p394-405Journal Article, 2000, DOI , URL
  • Zhang, R. and Itri, R. and Caffrey, M., Membrane structure characterization using variable-period x-ray standing waves, Biophysical Journal, 74, (4), 1998, p1924-1936Journal Article, 1998, DOI , URL
  • Itri, R. and Zhang, R. and Caffrey, M., Spatial resolution of the variable-period x-ray standing-wave method as applied to model membranes, Biophysical Journal, 73, (3), 1997, p1506-1515Journal Article, 1997, DOI , URL , TARA - Full Text
  • Cheng, A. and Caffrey, M., Free radical mediated x-ray damage of model membranes, Biophysical Journal, 70, (5), 1996, p2212-2222Journal Article, 1996, DOI , URL , TARA - Full Text
  • Chung, H. and Caffrey, M., Polymorphism, mesomorphism, and metastability of monoelaidin in excess water, Biophysical Journal, 69, (5), 1995, p1951-1963Journal Article, 1995, DOI , URL , TARA - Full Text
  • Chung, H. and Caffrey, M., The neutral area surface of the cubic mesophase: location and properties, Biophysical Journal, 66, (2), 1994, p377-381Journal Article, 1994, DOI , URL , TARA - Full Text
  • Briggs, J. and Caffrey, M., The temperature-composition phase diagram of monomyristolein in water: equilibrium and metastability aspects, Biophysical Journal, 66, (3), 1994, p573-587Journal Article, 1994, DOI , URL , TARA - Full Text
  • Briggs, J. and Caffrey, M., The temperature-composition phase diagram and mesophase structure characterization of monopentadecenoin in water, Biophysical Journal, 67, (4), 1994, p1594-1602Journal Article, 1994, DOI , URL , TARA - Full Text
  • Cheng, A. and Hummel, B. and Mencke, A. and Caffrey, M., Kinetics and mechanism of the barotropic lamellar gel/lamellar liquid crystal phase transition in fully hydrated dihexadecylphosphatidylethanolamine: a time-resolved x-ray diffraction study using pressure jump, Biophysical Journal, 67, (1), 1994, p293-303Journal Article, 1994, DOI , URL , TARA - Full Text
  • Zhu, T. and Caffrey, M., Thermodynamic, thermomechanical, and structural properties of a hydrated asymmetric phosphatidylcholine, Biophysical Journal, 65, (2), 1993, p939-954Journal Article, 1993, DOI , URL , TARA - Full Text
  • Koynova, R. and Caffrey, M., Mesophase transition temperatures as measured by fluorescence and calorimetry, Biophysical Journal, 65, (1), 1993, p550Journal Article, 1993, DOI , URL
  • El Ghachi, M. and Howe, N. and Huang, C.-Y. and Olieric, V. and Warshamanage, R. and Touzé, T. and Weichert, D. and Stansfeld, P.J. and Wang, M. and Kerff, F. and Caffrey, M., Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis, Nature Communications, 9, (1), 2018Journal Article, 2018, DOI , URL , TARA - Full Text
  • Yin, W. and Zhou, X.E. and Yang, D. and De Waal, P.W. and Wang, M. and Dai, A. and Cai, X. and Huang, C.-Y. and Liu, P. and Wang, X. and Yin, Y. and Liu, B. and Zhou, Y. and Wang, J. and Liu, H. and Caffrey, M. and Melcher, K. and Xu, Y. and Wang, M.-W. and Xu, H.E. and Jiang, Y., Crystal structure of the human 5-HT1Bserotonin receptor bound to an inverse agonist, Cell Discovery, 4, (1), 2018, p12-Journal Article, 2018, DOI , URL , TARA - Full Text
  • Wiktor, M. and Caffrey, M., Biophysical characterization and stabilization of detergent-solubilized lipoprotein N-acyl transferase from P. aeruginosa and E. coli, Biochimica et Biophysica Acta - Biomembranes, 1860, (6), 2018, p1384-1393Journal Article, 2018, DOI , URL
  • Boland C, Olatunji S, Bailey J, Howe N, Weichert D, Fetics S.K, Yu X, Merino-Gracia J, Delsaut C, Caffrey M, Membrane (and Soluble) Protein Stability and Binding Measurements in the Lipid Cubic Phase Using Label-Free Differential Scanning Fluorimetry, Analytical Chemistry, 90, (20), 2018, p12152 - 12160Journal Article, 2018, DOI , URL
  • Cherezov V, Liu W, Derrick JP, Luan B, Aksimentiev A, Katritch V, Caffrey M, In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin., Proteins, 71, (1), 2008, p24-34Journal Article, 2008, DOI
  • Cherezov V, Höfer N, Szebenyi DM, Kolaj O, Wall JG, Gillilan R, Srinivasan V, Jaroniec CP, Caffrey M, Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus., Structure (London, England : 1993), 16, (9), 2008, p1378-88Journal Article, 2008, DOI , TARA - Full Text
  • Martin Caffrey, On the Mechanism of Membrane Protein Crystallization in Lipidic Mesophases, Crystal Growth and Design, 8, (12), 2008, p4244-4254Journal Article, 2008, DOI
  • Caffrey M, Crystallizing membrane proteins for structure determination: use of lipidic mesophases., Annual Review of Biophysics, 38, 2009, p29-51Journal Article, 2009, DOI
  • Caffrey M, Cherezov V, Crystallizing membrane proteins using lipidic mesophases., Nature Protocols, 4, (5), 2009, p706-31Journal Article, 2009, DOI , URL , TARA - Full Text
  • Luan B, Carr R, Caffrey M, Aksimentiev A, The effect of calcium on the conformation of cobalamin transporter BtuB., Proteins, 78, (5), 2010, p1153-62Journal Article, 2010, DOI
  • Monoacylglycerols: The Workhorse Lipids for Crystallizing Membrane Proteins in Mesophases in, editor(s)Dale J. Benos; Sidney A. Simon , Current Topics in Membranes, San Diego, Elsevier, 2009, pp83-108 , [M. Caffrey, J. Lyons, T. Smyth and D.J. Hart]Book Chapter, 2009, DOI
  • Höfer N, Aragão D, Caffrey M, Crystallizing membrane proteins for structure determination using lipidic mesophases. , Journal of Visualized Experiments, 45, 2010, p1712-Journal Article, 2010, DOI , URL , TARA - Full Text
  • Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK, Structure and function of an irreversible agonist-ß(2) adrenoceptor complex., Nature, 469, (7329), 2011, p236-40Journal Article, 2011, DOI
  • Höfer N, Aragão D, Caffrey M, Crystallizing Transmembrane Peptides in Lipidic Mesophases, Biophysical Journal, 99, (3), 2010, pL23-L25Journal Article, 2010, DOI , URL , TARA - Full Text
  • Boyle-Roden, E., Hoefer, N., Dey, K. K., Grandinetti, P. J., Caffrey, M., High resolution 1H NMR of a lipid cubic phase using a solution NMR probe, Journal of Magnetic Resonance, 189, 2007, p13-19Journal Article, 2007, DOI
  • Luan, B., Caffrey, M., Aksimentiev, A., Structural Refinement of the OpcA Adhesin Using Molecular Dynamics., Biophysics Journal, 93, 2007, p3058-3069Journal Article, 2007, DOI , URL , TARA - Full Text
  • A general robotic approach for high-throughput automation in the handling of biosamples. in, editor(s)Eds Zhang, M., Nelson, B., Felder, R., , Life Science Automation - Fundamental and Applications., Norwood, MA. , Artech House, 2007, pp395-409 , [Zheng, Y.F., Peddi, A. Muthusubramaniam, L., Cherezov, V., and Caffrey, M.]Book Chapter, 2007
  • Yuan L., Zheng, Y.F., Chen. W., and Caffrey, M. , Automatic Mixing of Bio-Samples Using Micro-Channel and Centrifugation , Proc. IEEE Conference on Automation Science and Engineering,, IEEE Conference on Automation Science and Engineering,, Scottsdale, AZ, September 22-25, IEEE, 2007, pp634-639Conference Paper, 2007, DOI , URL , TARA - Full Text
  • Höfer, N., Kolaj, O., Li, H., Cherezov, V., Gillilan, R., Wall, J., Caffrey, M., Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus., Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 63, (8), 2007, p673-677Journal Article, 2007, DOI , URL , TARA - Full Text
  • Caffrey, M., Bernal and the genesis of structural biology. , Journal of Physics: Conference Series, 57, 2007, p17-28Journal Article, 2007, DOI , URL , TARA - Full Text
  • M. Peddi, A., Muthusubramaniam, L., Zheng, Y. F., Cherezov, V., Caffrey,, High-throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases., IEEE Transactions on Automation Science and Engineering, 4, (2), 2007, p129-140Journal Article, 2007, DOI , URL , TARA - Full Text
  • Cherezov, V., Caffrey, M. , Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction. , Faraday Discussions, 136, 2007, p188-205Journal Article, 2007, DOI , URL , TARA - Full Text
  • Miniaturization and Automation for High-throughput Membrane Protein Crystallization in Lipidic Mesophases. in, editor(s)Chayen. N. , Crystallization Strategies for Structural Genomics, 2007, pp169-194 , [Cherezov, V., Caffrey, M.]Book Chapter, 2007
  • Liu, W., Caffrey, M. , Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces., Biochemistry , 45, (39), 2006, p11713-11726Journal Article, 2006, DOI , URL , TARA - Full Text
  • Cherezov, V., Yamashita, E., Liu, W., Zhalnina, M., Cramer, W. A., Caffrey, M., In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution. , Journal of Molecular Biology, 364, (4), 2006, p716-734Journal Article, 2006, DOI , URL , TARA - Full Text
  • Cherezov, V., Caffrey, M., Picoliter-scale Crystallization of Membrane Proteins., Journal of Applied Crystallography, 39, (4), 2006, p604-609Journal Article, 2006, DOI
  • Cherezov, V., Clogston, J., Papiz, M., Caffrey, M., Room to move. Crystallizing membrane proteins in swollen lipidic mesophases., Journal of Molecular Biology, 357, 2006, p1605-1618Journal Article, 2006, DOI
  • Raman, P., Cherezov, V., Caffrey, M., The Membrane Protein Data Bank., Cellular and Molecular Life Sciences, 63, (1), 2006, p36-51.Journal Article, 2006, DOI
  • Siegel, D. P., Cherezov, V., Greathouse, D. V., Koeppe II, R. E., Killian, J. A., Caffrey, M. , Transmembrane Peptides Stabilize Inverted Cubic Phases in a Biphasic Length-dependent Manner: Implications for Protein-induced Membrane Fusion., Biophysical Journal, 90, 2006, p200-211Journal Article, 2006, DOI , URL , TARA - Full Text
  • Cherezov, M., Caffrey, M., A simple and inexpensive nanoliter volume dispenser for highly viscous materials used in membrane protein crystallization., Journal of Applied Crystallography, 38, 2005, p398-400Journal Article, 2005, DOI
  • Liu, W., Caffrey, M, Gramicidin Structure and Disposition in Highly Curved Membranes. , Journal Structural Biology, 150, (1), 2005, p23-40Journal Article, 2005, DOI
  • Clogston, J., Graciun, G., Hart, D. J., Caffrey, M., Controlling Release from the Lipidic Cubic Phase by Selective Alkylation., Journal of Controlled Release, 102, (2), 2005, p441-461Journal Article, 2005, DOI
  • Misquitta, L.V., Misquitta, Y., Cherezov, V., Slattery, O., Mohan, J. M., Hart, D., Zhalnina, M., Cramer, W. A., Caffrey, M., Membrane protein crystallization in lipidic mesophases with tailored bilayers. , Structure, 12, (12), 2004, p2113-2124Journal Article, 2004, DOI , TARA - Full Text
  • Misquitta, Y., Cherezov, V., Havas, F., Patterson, S., Mohan, J., Wells, A., Hart, D., Caffrey, M., Rational Design of Lipid for Membrane Protein Crystallization. , Journal of Structural Biology, 148, (2), 2004, p169-175Journal Article, 2004, DOI
  • *Cherezov, V., Peddi, A., Muthusubramaniam, L., Zheng, Y.F. M. Caffrey., A Robotic System For Crystallizing Membrane And Soluble Proteins In Lipidic Mesophases., Acta Crystallographica Section D, 60, (10), 2004, p1795-1807Journal Article, 2004, DOI
  • Misquitta, Y., Caffrey, M., Detergents Destabilize the Cubic Phase of Monoolein. Implications for Membrane Protein Crystallization., Biophysical Journal, 85, (5), 2003, p3084-3096Journal Article, 2003, DOI , URL , TARA - Full Text
  • Cherezov, V., Caffrey, M., Nano-volume Plates with Excellent Optical Properties for Fast, Inexpensive Crystallization Screening of Membrane Proteins., Journal of Applied Crystallography, 36, 2003, p1372-1377Journal Article, 2003, DOI
  • Cherezov, V., D. P. Siegel, W. Shaw, S. W. Burgess and M. Caffrey. , The kinetics of non-lamellar phase formation in dope-me: relevance to biomembrane fusion., Journal of Membrane, 195, (3), 2003, p165-182Journal Article, 2003, DOI
  • Caffrey, M., Membrane Protein Crystallization, Journal of Structural Biology, 142, (1), 2003, p108-132Journal Article, 2003, DOI
  • Caffrey, M, A lipid's eye view of membrane protein crystallization in mesophases., Current Opinion in Structural Biology, 10, (4), 2000, p486-497Journal Article, 2000, DOI
  • Wang, J., C. Wallace, I. Clark-Lewis, M. Caffrey , Structure characterization of membrane bound and surface adsrobed protein, Journal of Molecular Biology, 237, (1), 1994, p1-4Journal Article, 1994, DOI
  • *Chung, H., M. Caffrey , Curvature elastic energy fn. of cubic mesophase, Nature, 368, (6468), 1994, p224-226.Journal Article, 1994, DOI
  • Cheng, A., J. L. Hogan, M. Caffrey , X-Rays destroy membrane structure., Journal of Molecular Biology, 229, (2), 1993, p291-294Journal Article, 1993, DOI
  • *Wang, J., M.Bedzyk, M. Caffrey , Resonance-Enhanced X-Rays, Science, 258, (5083), 1992, p775-778Journal Article, 1992, DOI
  • Wang, J., M. Bedzyk, T. Penner, M. Caffrey , Structural studies of membranes and surface layers up to 1,000 A thick using X-ray standing waves., Nature, 354, (6352), 1991, p377-380Journal Article, 1991, DOI
  • Wang, J., M. Bedzyk, T. Penner, M. Caffrey , Structural studies of membranes and surface layers up to 1,000 A thick using X-ray standing waves., Nature, 354, (6352), 1991, p377-380Journal Article, 1991, DOI
  • Wang, J., M. Bedzyk, T. Penner, M. Caffrey , Structural studies of membranes and surface layers up to 1,000 A thick using X-ray standing waves., Nature, 354, (6352), 1991, p377-380Journal Article, 1991, DOI
  • Mencke, A. P., M. Caffrey, Kinetics and mechanism of the pressure-induced lamellar order/disorder transition in phosphatidylethanolamine, Biochemistry, 30, (9), 1991, p2453-2463Journal Article, 1991, DOI
  • Caffrey, M., J. L. Hogan, A. S. Rudolph, Diacetylenic lipid microstructures: structural characterization by X-ray diffraction and comparison with the saturated phosphatidylcholine analogue., Biochemistry, 30, (8), 1991, p2134-2146Journal Article, 1991, DOI
  • *Bedzyk, M., M. Bommarito, M. Caffrey, T. Penner, Diffuse-Double Layer at a Membrane/Aqueous Interface Measured with X-ray Standing Waves, Science, 248, 1990, p52-56Journal Article, 1990, DOI
  • Caffrey, M. , Lipid phase transition kinetics by time-resolved x-ray diffraction., Annual Review of Biophysics and Biophysical Chemistry , 18, 1989, p159-186Journal Article, 1989, DOI
  • Bedzyk, M. D.H. Bilderback,, M. Bommarito, M. Caffrey, And J. Schildkraut , X-ray standing waves. A molecular yardstick for biomembranes, Science, 241, (4874), 1988, p1788-1791Journal Article, 1988, DOI
  • Caffrey, M. , LIPIDAT A database of thermodynamic data and associated information on lipid mesomorphic and polymorphic transitions. , Boca Raton, FL., CRC Press, Inc, 1993, 1 - 305ppBook, 1993
  • Caffrey, M., Lipid thermotropic phase transitions LIPIDAT. NIST Standard Reference Database 34. , 1993, -Miscellaneous, 1993
  • Caffrey, M., Lipid Data Bank. - A relational database of thermodynamic data on lipid mesophase and crystal polymorphic transitions on the Web. , 1996, -Miscellaneous, 1996, URL
  • Caffrey, M., The Membrane Protein Data Bank. - An on-line, searchable, relational database with select structural and functional information on membrane proteins and peptides. , 2005, -Miscellaneous, 2005, URL
  • Caffrey, M, Kinsella, JE, Isoenzymes of an acyltransferase from rabbit mammary gland: Solubilization of the micelle-specific species with Tritron X-100, Biochemical and Biophysical Research Communications, 71, 1976, p484-491Journal Article, 1976, DOI
  • Caffrey M. & Kinsella, JE, Growth and acyltransferase activity of rabbit mammary gland during pregnancy and lactation, Journal of Lipid Research, 18, (1), 1977, p44-52.Journal Article, 1977, URL
  • Caffrey, M. & Kinselaa, JE., Experimental difficulties in assaying a membrane-bound acyltransferase from rabbit mammary tissue, International Journal of Biochemistry, 8, 1977, p39-51Journal Article, 1977, DOI
  • Caffrey, M. & Kinsella, JE., Kinetics of a micelle specific palmitoyltransferase isoenzyme from rabbit mammary gland., Lipids, 12, 1977, p556-562Journal Article, 1977, DOI
  • Caffey M. & Kinsella, JE., Sensitivity of the molar absortivity value to sample and instrument characteristics, with reference to the Ellman Reagent (DTNB), International Journal of Biochemistry, 6, 1975, p877-883Journal Article, 1975, DOI
  • Caffrey, M., Infante, J. and Kinsella, J. E. , Isoenzymes of an acyltransferase from rabbit mammary gland: Evidence from biphasic substrate saturation kinetics., FEBS Letters, 52, (1), 1975, p116-120Journal Article, 1975, DOI
  • Caffrey M, Kinsella JE, Properties of palmitoyl-CoA: monopalmitoyl-sn-glycerol 3-phosphate palmitoyltransferase from rabbit mammary gland., The International journal of biochemistry, 9, (4), 1978, p239-48Journal Article, 1978, DOI
  • Caffrey MC, Kinsella JE, Solubilization of a micelle specific acyltransferase from rat mammary microsomes., The International journal of biochemistry, 9, (6), 1978, p381-384Journal Article, 1978, DOI
  • Caffrey M, Feigenson GW, Fluorescence quenching in model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics., Biochemistry, 20, (7), 1981, p1949-1961Journal Article, 1981, DOI
  • Caffrey M, Feigenson GW, Influence of metal ions on the phase properties of phosphatidic acid in combination with natural and synthetic phosphatidylcholines: an X-ray diffraction study using synchrotron radiation., Biochemistry, 23, (2), 1984, p323-31Journal Article, 1984
  • Caffrey M, Bilderback DH, Kinetics of the main phase transition of hydrated lecithin monitored by real-time X-ray diffraction., Biophysical journal, 45, (3), 1984, p627-631Journal Article, 1984, DOI , TARA - Full Text
  • Caffrey M, Kinetics and mechanism of the lamellar gel/lamellar liquid-crystal and lamellar/inverted hexagonal phase transition in phosphatidylethanolamine: a real-time X-ray diffraction study using synchrotron radiation., Biochemistry, 24, (18), 1985, p4826-4844Journal Article, 1985, DOI
  • Caffrey M, Hing FS, A temperature gradient method for lipid phase diagram construction using time-resolved x-ray diffraction., Biophysical journal, 51, (1), 1987, p37-46Journal Article, 1987, DOI , URL , TARA - Full Text
  • Caffrey M, The combined and separate effects of low temperature and freezing on membrane lipid mesomorphic phase behavior: relevance to cryobiology., Biochimica et biophysica acta, 896, (1), 1987, p123-127Journal Article, 1987, DOI
  • Caffrey M, Kinetics and mechanism of transitions involving the lamellar, cubic, inverted hexagonal, and fluid isotropic phases of hydrated monoacylglycerides monitored by time-resolved X-ray diffraction., Biochemistry, 26, (20), 1987, p6349-6363Journal Article, 1987, DOI
  • Caffrey M, Morris SJ, Feigenson GW, Uranyl acetate induces gel phase formation in model lipid and biological membranes., Biophysical Journal, 52, (3), 1987, p501-505Journal Article, 1987, DOI
  • Caffrey M, Werner BG, Priestley DA, A crystalline lipid phase in a dry biological system: evidence from X-ray diffraction analysis of Typha latifolia pollen., Biochimica et biophysica acta, 921, (1), 1987, p124-34Journal Article, 1987, DOI
  • Bedzyk MJ, Bilderback DH, Bommarito GM, Caffrey M, Schildkraut JS, X-ray standing waves: a molecular yardstick for biological membranes., Science (New York, N.Y.), 241, (4874), 1988, p1788-91Journal Article, 1988, DOI
  • Caffrey M, A lyotrope gradient method for liquid crystal temperature-composition-mesomorph diagram construction using time-resolved x-ray diffraction., Biophysical Journal, 55, (1), 1989, p47-52Journal Article, 1989, DOI , URL , TARA - Full Text
  • Bedzyk MJ, Bommarito GM, Caffrey M, Penner TL, Diffuse-double layer at a membrane-aqueous interface measured with x-ray standing waves., Science (New York, N.Y.), 248, (4951), 1990, p52-56Journal Article, 1990, DOI
  • Caffrey M, Fanger G, Magin RL, Zhang J, Kinetics of the premelting (L beta'-P beta') and main transition (P beta'-L alpha) in hydrated dipalmitoylphosphatidylcholine. A time-resolved x-ray diffraction study using microwave-induced temperature-jumps., Biophysical journal, 58, (3), 1990, p677-86Journal Article, 1990, DOI , URL , TARA - Full Text
  • Caffrey, M and Feigenson, G.W., Fatty acyl chain characteristics of phosphatidylcholines affect Ca2+-ATPase enzymatic activity but not the affinity of the protein for these different lipid species., Biochemical Society Transactions, 9, 1981, p155-156Journal Article, 1981
  • Caffrey, M., Bilderback, D.H, Real-time X-ray diffraction using synchrotron radiation: System characterization and applications, Nuclear Instruments and Methods In Physics Research, 208, (1-3), 1983, p495-510Journal Article, 1983, DOI
  • Caffrey, M., Mynihan, D. and Hogan, J., A database of lipid phase transition temperatures and enthalpy changes., Chem Physics Lipids, 57, (2-3), 1990, p275-291Journal Article, 1990, DOI
  • Caffrey M, Magin RL, Hummel B, Zhang J, Kinetics of the lamellar and hexagonal phase transitions in phosphatidylethanolamine. Time-resolved x-ray diffraction study using a microwave-induced temperature jump., Biophysical journal, 58, (1), 1990, p21-9Journal Article, 1990, DOI , URL , TARA - Full Text
  • H. C. Gerritsen, M. Caffrey, Water transport in lyotropic liquid crystals and lipid-water systems: mutual diffusion coefficient determination, Journal of Physical Chemistry, 94, (2), 1990, p944-948Journal Article, 1990, DOI
  • Mencke AP, Caffrey M, Kinetics and mechanism of the pressure-induced lamellar order/disorder transition in phosphatidylethanolamine: a time-resolved X-ray diffraction study., Biochemistry, 30, (9), 1991, p2453-63Journal Article, 1991
  • Caffrey M, Hogan J, Rudolph AS, Diacetylenic lipid microstructures: structural characterization by X-ray diffraction and comparison with the saturated phosphatidylcholine analogue., Biochemistry, 30, (8), 1991, p2134-46Journal Article, 1991, DOI
  • Caffrey M, Hogan J, Mencke A, Kinetics of the barotropic ripple (P beta')/lamellar liquid crystal (L alpha) phase transition in fully hydrated dimyristoylphosphatidylcholine (DMPC) monitored by time-resolved x-ray diffraction., Biophysical journal, 60, (2), 1991, p456-66Journal Article, 1991, DOI , URL , TARA - Full Text
  • Caffrey, M and Feigenson, G.W., The influence of metal ions on the phase properties of phosphatidic acid in combination with natural and synthetic phosphatidylcholines: An x-ray diffraction study using synchrotron radiation. , Biochemistry, 23, (2), 1984, p323-331Journal Article, 1984
  • David T. Grubb, Jay J.-H. Liu, Martin Caffrey, Donald H. Bilderback, Real-time small-angle x-ray scattering during annealing of polymer single crystals. , Journal of Polymer Science: Polymer Physics Edition, 22, (3), 1984, p367-378Journal Article, 1984, DOI
  • Martin Caffrey, X-Radiation damage of hydrated lecithin membranes detected by real-time x-ray diffraction using wiggler-enchanced synchrotron radiation as the ionizing radiation source, Nuclear Instruments and Methods in Physics Research, 222, (1-2), 1984, p329-338Journal Article, 1984, DOI
  • Caffrey, M. and Lew, R.R., The Ca2+ induced phase transformation in soybean root microsomal membranes is a consequence of phospholipase activity, Plant Cell Physiology, 27, 1986, p1091-1100Journal Article, 1986, URL
  • Phoebe Dea, Laurence T. Pearson, Martin Caffrey and Sunney I. Chan, Effect of chlorophyll a on the phase behavior of hydrated monogalactosyl diacylglyceride, Biochimica et Biophysica Acta (BBA) - Biomembranes, 896, (1), 1987, p11-18Journal Article, 1987, DOI
  • Caffrey, M. and Bywater, M, Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils, Journal of the Society of Cosmetic Chemists, 39, (3), 1988, p159-167Journal Article, 1988, URL , TARA - Full Text
  • Caffrey M, Fonseca V, Leopold AC., Lipid-sugar interaction: Relevance to anhydrous biology, Plant Physiology, 86, (3), 1988, p754-758Journal Article, 1988, URL , TARA - Full Text
  • Martin Caffrey, Denis Moynihan, Jacqueline Hogan, A database of lipid phase transition temperatures and enthalpy changes., J. Chem. Inf. Comput. Sci., , 31, (2), 1991, p275-284Journal Article, 1991, DOI
  • Caffrey, M. and Hogan, J., LIPIDAT: A database of lipid phase transition temperatures and enthalpy changes. DMPC data subset analysis. , Chem. Phys. Lipids, 61, 1992, p1-109Journal Article, 1992, DOI
  • Lynch DV, Caffrey M, Hogan J, Steponkus PL, Calorimetric and x-ray diffraction studies of rye glucocerebroside mesomorphism, Biophysical Journal, 61, (5), 1992, p1289-1300Journal Article, 1992, DOI , URL , TARA - Full Text
  • Mencke, A., Cheng, A-c. and Caffrey, M. , A simple apparatus for time-resolved x-ray diffraction studies utilizing static pressures and pressure-jumps up to 300 MPa, Review of Science Instruments, 64, 1993, p383-389Journal Article, 1993
  • Chung H, Caffrey M, Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction., Biophysical journal, 63, (2), 1992, p438-47Journal Article, 1992, DOI , URL , TARA - Full Text
  • Dianfan Li, Martin Caffrey, Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes, PNAS, 108, (21), 2011, p8639-8644Journal Article, 2011, DOI , URL , TARA - Full Text
  • Caffrey M, Li D, Dukkipati A, Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes., Biochemistry, 51, (32), 2012, p6266-88Journal Article, 2012, DOI , TARA - Full Text
  • Lyons JA, Aragão D, Slattery O, Pisliakov AV, Soulimane T, Caffrey M, Structural insights into electron transfer in caa3-type cytochrome oxidase., Nature, 487, (7408), 2012, p514-8Journal Article, 2012
  • Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK, Crystal structure of the ß2 adrenergic receptor-Gs protein complex., Nature, 477, (7366), 2011, p549-55Journal Article, 2011
  • Caffrey M, Crystallizing membrane proteins for structure-function studies using lipidic mesophases., Biochemical Society transactions, 39, (3), 2011, p725-32Journal Article, 2011, DOI , TARA - Full Text
  • Li D, Caffrey M, Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes., Proceedings of the National Academy of Sciences of the United States of America, 108, (21), 2011, p8639-44Journal Article, 2011, DOI , TARA - Full Text
  • Aherne, M, Lyons, JA, Caffrey, M, A fast, simple and robust protocol for growing crystals in the lipidic cubic phase, Journal of Applied Crystallography , 45, (6), 2012, p1330-1333Journal Article, 2012, DOI , TARA - Full Text
  • Khelashvili, G, Albornoz, PBC, Johner, N, Mondal, S, Caffrey, M, Weinstein, H, Why GPCRs behave differently in cubic and lamellar lipidic mesophases, Journal of the American Chemical Society, 134, (38), 2012, p15858-15868Journal Article, 2012, DOI , TARA - Full Text
  • Crystallizing membrane proteins for structure-function studies using lipidic mesophases in, editor(s)Randy,Urzhumtsev A.G.,Alexandre A.G.,Lunin V.Y. , NATO Science for Peace and Security Series A: Chemistry and Biology, 2013, pp33-46 , [Caffrey, M.]Book Chapter, 2013, DOI
  • Li, DF, Lyons, JA, Pye, VE, Vogeley, L, Aragao, D, Kenyon, CP, Shah, STA, Doherty, C, Aherne, M, Caffrey, M, Crystal structure of the integral membrane diacylglycerol kinase, Nature, 497, (7450), 2013, p521-524Journal Article, 2013, DOI , TARA - Full Text
  • Li D, Boland C, Aragao D, Walsh K, Caffrey M, Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography., Journal of visualized experiments : JoVE, (67), 2012, pe4001Journal Article, 2012
  • Li, D., Boland, C., Walsh, K., Caffrey, M., Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases, Journal of Visualised Experiments, 67, 2012, pe4000Journal Article, 2012, DOI , TARA - Full Text
  • Li, DF, Howe, N, Dukkipati, A, Shah, STA, Bax, BD, Edge, C, Bridges, A, Hardwicke, P, Singh, OMP, Giblin, G, Pautsch, A, Pfau, R, Schnapp, G, Wang, MT, Olieric, V, Caffrey, M, Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy, CRYSTAL GROWTH & DESIGN, 14, (4), 2014, p2034-2047Journal Article, 2014, DOI , TARA - Full Text
  • Johner, N, Mondal, S, Morra, G, Caffrey, M, Weinstein, H, Khelashvili, G, Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, (8), 2014, p3271-3284Journal Article, 2014, DOI , TARA - Full Text
  • Weierstall, U., James, D., Wang, C., (...), Caffrey, M., Cherezov, V., Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography, Nature Communications, 5, 2014, p3309-Journal Article, 2014, DOI , TARA - Full Text
  • Liu, W., Wacker, D., Gati, C., (...), Stevens, R.C., Cherezov, V., Serial femtosecond crystallography of G protein-coupled receptors, Science, 342, (6165), 2013, p1521-1524Journal Article, 2013, DOI
  • Hopper, JTS, Yu, YTC, Li, DF, Raymond, A, Bostock, M, Liko, I, Mikhailov, V, Laganowsky, A, Benesch, JLP, Caffrey, M, Nietlispach, D, Robinson, CV, Detergent-free mass spectrometry of membrane protein complexes, NATURE METHODS, 10, (12), 2013, p1206-+Journal Article, 2013, DOI
  • Li, DF, Shah, STA, Caffrey, M, Host Lipid and Temperature as Important Screening Variables for Crystallizing Integral Membrane Proteins in Lipidic Mesophases. Trials with Diacylglycerol Kinase, CRYSTAL GROWTH & DESIGN, 13, (7), 2013, p2846-2857Journal Article, 2013, DOI , TARA - Full Text
  • Höfer N, Aragão D, Lyons JA, Caffrey M., Membrane Protein Crystallization in Lipidic Mesophases. Hosting lipid affects on the crystallization and structure of a transmembrane peptide., Cryst Growth Design, 11, (4), 2011, p1182-1192Journal Article, 2011, DOI , TARA - Full Text
  • Li, DF, Lee, J, Caffrey, M, Crystallizing Membrane Proteins in Lipidic Mesophases. A Host Lipid Screen, CRYSTAL GROWTH & DESIGN, 11, (2), 2011, p530-537Journal Article, 2011, DOI , TARA - Full Text

Research Expertise

  • Title
    Membrane Protein Structure. Use of lipidic mesophases,
    Summary
    $928,344. The major goals of this project weas to decipher the mechanism of membrane protein crystallization and to implement it in the crystallization of membrane proteins.
    Funding Agency
    NIH
    Date From
    1/2001
    Date To
    12/2005
  • Title
    Postdoctoral Fellow
    Summary
    $20,500/annum from the Government of Brazil to support Dr. R. Itri from University of Sao Paolo, (M. Caffrey, Sponsor)
    Funding Agency
    Government of Brazil
    Date From
    1995
    Date To
    1997
  • Title
    A Web-based Relational Database for Thermodynamic Data on Lipid Mesomorphase Transitions and Miscibility.
    Summary
    PI, M. Caffrey; $444,441.
    Funding Agency
    NSF
    Date From
    01/2000
    Date To
    12/2003
  • Title
    Long Term (2 year) proposal: Toward an understanding of the mechanism of x-radiation damage to protein crystals. Proposal written by MC.
    Summary
    ESRF, Grenoble, France. Co-PIs: S. McSweeney, R. Ravelli, E. Garmon. 2 weeks of beamtime approved for use as short-term proposal. Beamtime used in Summer 2000.
    Date To
    Summer 2000
  • Title
    SFI. Strategic Research Cluster.
    Summary
    PI, K. Dawson (UCD). Total award, € 7,241,740. Collaborator, M. Caffrey along with several others, €250,000. BioNanoInteractions: Interactions of engineered nanoparticles with biological systems - a rational basis for nanotoxicology and nanomedicine.
    Funding Agency
    SFI
  • Title
    Membrane Fusion. Intermediates and transbilayer peptides.
    Summary
    $1,031,267.
    Funding Agency
    NIH.
    Date From
    12/01/97
    Date To
    11/30/01
  • Title
    Membrane disposition of cytochrome c.
    Summary
    Summer 99, $5,000.
    Funding Agency
    Faculty Summer Research Program. Petroleum Research Fund, American Chemical Society
    Date To
    1999
  • Title
    Research Experience for Undergraduate Students (REU Award)
    Summary
    $5,000, Summer internship support for Ms. Perryman from Spellman College, Atlanta, GA.
    Funding Agency
    NSF
    Date From
    6/1996
    Date To
    9/1996
  • Title
    Membrane Protein Structure. Use of lipidic mesophases
    Summary
    $928,344. The major goals of this project weas to decipher the mechanism of membrane protein crystallization and to implement it in the crystallization of membrane proteins.
    Funding Agency
    NIH
    Date From
    1/2001
    Date To
    12/2005
  • Title
    Membrane disposition of cytochrome c - An x-ray standing wave study.
    Summary
    Petroleum Research Fund, American Chemical Society, , $50,000.
    Funding Agency
    Petroleum Research Fund
    Date From
    5/1996
    Date To
    5/1998
  • Title
    Marie Curie. Intra European Fellowship.
    Summary
    €133,440.77. Postdoc funding for Dr. D. Aragao. Commission Des Communautes
    Funding Agency
    Marie Curie
    Date From
    01/05/09
    Date To
    30/04/11
  • Title
    An environmentally sensitive method using biocmpatible absorbent materials for water treatemnet.
    Summary
    PI: Caffrey, Co-PIs: J. Rathman, D. Tomasko, H. Walker. $80,000.
    Funding Agency
    OSU Office of Research Seed Grant
    Date From
    5/1997
    Date To
    12/2001
  • Title
    SFI. Equipment Supplement.
    Summary
    PI, M. Caffrey. €264,218, 1,500 Plate-capacity Automatic Crystallization Plate Imager
    Funding Agency
    SFI
    Date From
    12/2007
    Date To
    05/2008
  • Title
    Long Term (3 year) proposal: Toward an understanding of the mechanism of x-radiation damage to protein crystals. Proposal written by MC.
    Summary
    ESRF, Grenoble, France. Co-PIs: S. McSweeney, R. Ravelli, E. Garmon. 3 weeks of beamtime approved.
    Date From
    2001
  • Title
    Short term proposal (1 quarter) proposal:Toward an understanding of the mechanism of x-radiation damage to lipids and membranes. Proposal written by MC.
    Summary
    ESRF, Grenoble, France. Co-PIs: O. Diat, J-M Petit. . 4 days of beamtime approved.
    Date From
    9/1999
    Date To
    Active in 2000.
  • Title
    Structure-Function Studies of Membrane Proteins Involved in Quorum Sensing and the Pathogenicity of Pseudomonas aeruginosa
    Summary
    SFI: Investigatorship Award. PI, M. Caffrey. Direct costs €2,521,216. The major goal of this project is to crystallize and to solve the X-ray structure of a select group of membrane proteins involved in quorum sensing and the pathogenicity of Pseudomonas aeruginosa. There is no overlap with the current proposal.
    Funding Agency
    SFI
    Date From
    01/06/08
    Date To
    31/05/13
  • Title
    National Synchrotron Light Source, Beamtime Proposal
    Summary
    70 days of beamtime approved on beam line X15A. .
    Date From
    6/1995
    Date To
    5/1997
  • Title
    Structure-Function Studies of Membrane Proteins Involved in Quorum Sensing and the Pathogenicity of Pseudomonas aeruginosa
    Summary
    PI, M. Caffrey. . Direct costs €2,521,216.
    Funding Agency
    SFI
    Date From
    01/06/08
    Date To
    31/05/13
  • Title
    National Synchrotron Light Source
    Summary
    Beamtime Proposal, 2/95. 24 days of beamtime approved on beam line X9B.
    Date From
    6/1995
    Date To
    5/1997
  • Title
    A Relational Database for Thermodynamic and Structure Data on Lipids.
    Summary
    PI, M. Caffrey;. $241,562.
    Funding Agency
    NSF;
    Date From
    9/1995
    Date To
    08/2000
  • Title
    Membrane Proteins. Crystallogenesis and X-ray Structure
    Summary
    PI, M. Caffrey. Direct costs $187,500/year. Total costs $202,500/year.
    Funding Agency
    NIH
    Date From
    01/09/05
    Date To
    31/08/10.
  • Title
    Robotic Dispensing of Cubic Phase for Crystallizing Membrane Proteins
    Summary
    Co-PI with Y. Zheng, Electrical Engineering, OSU.
    Funding Agency
    NSF
    Date From
    7/2003
    Date To
    7/2007
  • Title
    Membrane Proteins. Crystallogenesis and X-ray Structure
    Summary
    PI, M. Caffrey. Direct costs $187,500/year. Total costs $202,500/year. Instrumentation Supplement awarded 2008, €15,000 The purpose of this project is to develop and to implement the lipidic mesophase method for membrane protein crystallogenesis.
    Funding Agency
    NIH
    Date From
    01/09/05
    Date To
    31/08/10.
  • Title
    The Structural Biology of Membrane Proteins
    Summary
    PI, M. Caffrey. . Total Award, €2.45m. The purpose of this award was to enable the PI to establish a research program in the area of membrane structural and functional biology at The University of Limerick, Ireland. The bulk of the funding for this project was directed to equipping the lab at UL with X-ray and other biochemical/biophysical instrumentation, and to support a limited number of personnel. The University of Limerick does not have a strong tradition in fundamental research in the biosciences. The PI's charge is to contribute to getting such activity underway. His appointment at UL is strictly a research position and does not require teaching.
    Funding Agency
    SFI
    Date From
    11/2003
    Date To
    05/2008
  • Title
    A Web-based Relational Database for Thermodynamic Data on Lipid Mesomorphase Transitions and Miscibility. Supplement to Support Workshop "Databases for Biophysicists" at Biophysical Society Meeting, Boston, MA.
    Summary
    NSF; DBI 9981990; PI, M. Caffrey; $21,597.
    Funding Agency
    NSF
    Date From
    1/2000
    Date To
    12/2002
  • Title
    SFI. Undergraduate Research Experience and Knowledge Awards.
    Summary
    PI, M. Caffrey. € 6,300, 02/in.1/B266ur7.2, Bishal Singh. €5,300, 02/in.1/B266ur7.1, Zuzanna Kurowska The structure and function of membrane proteins 05/08 - 09/08, €5,600, 02/IN1/B266 UR08, Rachel Tiedt. Synthesis of lipids for use in in meso crystallogenesis.
    Funding Agency
    SFI
    Date From
    05/2007
    Date To
    09/2008
  • Title
    Cooperative Science and Technology Sub-Programme COLLABORATIVE LINKAGE GRANT,
    Summary
    $9,500. A web-based database for thermodynamic and structure data on lipids. Grant awarded but declined.
    Date From
    03/2000
    Date To
    02/2002