Professor Luke O'Neill

• Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919Journal Article, 2014, DOI , TARA - Full Text
• Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347Miscellaneous, 2015, DOI
• Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257Journal Article, 2015, DOI , URL
• Haneklaus M, O'Neill L.A.J, NLRP3 at the interface of metabolism and inflammation, Immunological Reviews, 265, (1), 2015, p53 - 62Journal Article, 2015, DOI , URL
• Menon D, Coll R, O'Neill L.A.J, Board P.G, GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway, Journal of Cell Science, 128, (10), 2015, p1982 - 1990Journal Article, 2015, DOI , URL
• O'Neill L.A.J, A Broken Krebs Cycle in Macrophages, Immunity, 42, (3), 2015, p393 - 394Journal Article, 2015, DOI , URL
• Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA, Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1., Proceedings of the National Academy of Sciences of the United States of America, 112, (23), 2015, p7231-6Journal Article, 2015, DOI , TARA - Full Text
• Galván-Peña S, O'Neill LA, Metabolic reprograming in macrophage polarization., Frontiers in immunology, 5, 2014, p420Journal Article, 2014, DOI , TARA - Full Text
• van den Bosch MW, Palsson-Mcdermott E, Johnson DS, O'Neill LA, LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production., The Journal of biological chemistry, 289, (33), 2014, p22980-90Journal Article, 2014, DOI , TARA - Full Text
• Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60Journal Article, 2015, DOI , TARA - Full Text
• Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, mTOR- and HIF-1"-mediated aerobic glycolysis as metabolic basis for trained immunity., Science (New York, N.Y.), 345, (6204), 2014, p1250684Journal Article, 2014, DOI , TARA - Full Text
• Greenhill CJ, Jones GW, Nowell MA, Newton Z, Harvey AK, Moideen AN, Collins FL, Bloom AC, Coll RC, Robertson AA, Cooper MA, Rosas M, Taylor PR, O'Neill LA, Humphreys IR, Williams AS, Jones SA, Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction., Arthritis research & therapy, 16, (4), 2014, p419Journal Article, 2014, DOI , TARA - Full Text
• Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA, Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation., The Journal of biological chemistry, 289, (10), 2014, p6429-37Journal Article, 2014, DOI , TARA - Full Text
• Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA, The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10., The Journal of biological chemistry, 289, (7), 2014, p4316-25Journal Article, 2014, DOI , TARA - Full Text
• Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449Journal Article, 2016, DOI , URL , TARA - Full Text
• Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379Journal Article, 2016, URL , TARA - Full Text
• McIntyre J, Verma N.K, Smith R.J, Moore C, Nerl H, McEvoy N, Berner N, McGovern I, Khan U, Lyons P, O'Neill L, Nicolosi V, Duesberg G.S, Byrne H.J, Coleman J, Volkov Y, A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene, RSC Advances, 6, (70), 2016, p65299 - 65310Journal Article, 2016, DOI , URL , TARA - Full Text
• Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427-Journal Article, 2016, DOI , URL
• Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679Journal Article, 2015, DOI , URL
• Arbore G, West E.E, Spolski R, Robertson A.A.B, Klos A, Rheinheimer C, Dutow P, Woodruff T.M, Yu Z.X, O'Neill L.A, Coll R.C, Sher A, Leonard W.J, Köhl J, Monk P, Cooper M.A, Arno M, Afzali B, Lachmann H.J, Cope A.P, Mayer-Barber K.D, Kemper C, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells, Science, 352, (6292), 2016Journal Article, 2016, DOI , URL
• Joosten L.A.B, Abdollahi-Roodsaz S, Dinarello C.A, O'Neill L, Netea M.G, Toll-like receptors and chronic inflammation in rheumatic diseases: New developments, Nature Reviews Rheumatology, 12, (6), 2016, p344 - 357Journal Article, 2016, DOI , URL
• O'Neill L.A.J, Pearce E.J, Immunometabolism governs dendritic cell and macrophage function, Journal of Experimental Medicine, 213, (1), 2016, p15 - 23Journal Article, 2016, DOI , URL
• Mills E.L, O'Neill L.A, Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal, European Journal of Immunology, 46, (1), 2016, p13 - 21Journal Article, 2016, DOI , URL
• O'Neill L.A.J, How Low Cholesterol Is Good for Anti-viral Immunity, Cell, 163, (7), 2015, p1572 - 1574Journal Article, 2015, DOI , URL
• Norata G.D, Caligiuri G, Chavakis T, Matarese G, Netea M.G, Nicoletti A, O'Neill L.A.J, Marelli-Berg F.M, The Cellular and Molecular Basis of Translational Immunometabolism, Immunity, 43, (3), 2015, p421 - 434Journal Article, 2015, DOI , URL
• Kelly B, Tannahill G.M, Murphy M.P, O'Neill L.A.J, Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages, Journal of Biological Chemistry, 290, (33), 2015, p20348 - 20359Journal Article, 2015, DOI , URL , TARA - Full Text
• Finucane O.M, Lyons C.L, Murphy A.M, Reynolds C.M, Klinger R, Healy N.P, Cooke A.A, Coll R.C, Mcallan L, Nilaweera K.N, O'Reilly M.E, Tierney A.C, Morine M.J, Alcala-Diaz J.F, Lopez-Miranda J, O'Connor D.P, O'Neill L.A, Mcgillicuddy F.C, Roche H.M, Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity, Diabetes, 64, (6), 2015, p2116 - 2128Journal Article, 2015, DOI , URL
• Kelly B, O'Neill L.A.J, Metabolic reprogramming in macrophages and dendritic cells in innate immunity, Cell Research, 25, (7), 2015, p771 - 784Journal Article, 2015, DOI , URL
• McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787Journal Article, 2016, DOI
• C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316Journal Article, 2017, TARA - Full Text
• ZasÅ'ona Z, Palsson-McDermott E.M, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran S.E, Peters-Golden M, O'Neill L.A.J, The induction of Pro-IL-1β by lipopolysaccharide requires endogenous prostaglandin E2 production, Journal of Immunology, 198, (9), 2017, p3558 - 3564Journal Article, 2017, DOI , URL
• Haneklaus M, O'Neil J.D, Clark A.R, Masters S.L, O'Neill L.A.J, The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome, Journal of Biological Chemistry, 292, (17), 2017, p6869 - 6881Journal Article, 2017, DOI , URL
• Mills E.L, Kelly B, O'Neill L.A.J, Mitochondria are the powerhouses of immunity, Nature Immunology, 18, (5), 2017, p488 - 498Journal Article, 2017, DOI , URL
• O'Neill L, Immunometabolism and the land of milk and honey, Nature Reviews Immunology, 17, (4), 2017, p217-Journal Article, 2017, DOI , URL
• O'Neill L.A.J, The Hunger Games: Salmonella, Anorexia, and NLRP3, Cell Metabolism, 25, (2), 2017, p225 - 226Journal Article, 2017, DOI , URL
• Van den Bossche J, O'Neill L.A, Menon D, Macrophage Immunometabolism: Where Are We (Going)?, Trends in Immunology, 38, (6), 2017, p395-406Journal Article, 2017, DOI , URL
• Hughes M.M, Mcgettrick A.F, O'Neill L.A.J, Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages, Microbiology Spectrum, 5, (1), 2017, p0044-Journal Article, 2017, DOI , URL
• Basiorka A.A, McGraw K.L, Eksioglu E.A, Chen X, Johnson J, Zhang L, Zhang Q, Irvine B.A, Cluzeau T, Sallman D.A, Padron E, Komrokji R, Sokol L, Coll R.C, Robertson A.A.B, Cooper M.A, Cleveland J.L, O'Neill L.A, Wei S, List A.F, The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype, Blood, 128, (25), 2016, p2960 - 2975Journal Article, 2016, DOI , URL
• Arts R.J.W, Novakovic B, ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng S.-C, Wang S.-Y, Habibi E, Gonçalves L.G, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk F.L, Williams D.L, van der Meer J.W.M, Logie C, O'Neill L.A, Dinarello C.A, Riksen N.P, van Crevel R, Clish C, Notebaart R.A, Joosten L.A.B, Stunnenberg H.G, Xavier R.J, Netea M.G, Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity, Cell Metabolism, 24, (6), 2016, p807 - 819Journal Article, 2016, DOI , URL
• Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240-Journal Article, 2016, DOI , URL
• Brady G, Boggan L, Bowie A, O'Neill L.A.J, Erratum: Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1 (The Journal of Biological Chemistry (2005) 280 (30723-30734) DOI: 10.1074/jbc.M500435200), Journal of Biological Chemistry, 291, (48), 2016, p25278-Journal Article, 2016, DOI , URL
• Pinkerton J.W, Kim R.Y, Robertson A.A.B, Hirota J.A, Wood L.G, Knight D.A, Cooper M.A, O'Neill L.A.J, Horvat J.C, Hansbro P.M, Inflammasomes in the lung, Molecular Immunology, 86, 2017, p44-55Journal Article, 2017, DOI , URL
• O'Neill L.A.J, A Metabolic Roadblock in Inflammatory Macrophages, Cell Reports, 17, (3), 2016, p625 - 626Journal Article, 2016, DOI , URL , TARA - Full Text
• Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13Journal Article, 2016, DOI , URL
• Corcoran S.E, O'Neill L.A.J, HIF1α and metabolic reprogramming in inflammation, Journal of Clinical Investigation, 126, (10), 2016, p3699 - 3707Journal Article, 2016, DOI , URL
• O'Neill L.A.J, Kishton R.J, Rathmell J, A guide to immunometabolism for immunologists, Nature Reviews Immunology, 16, (9), 2016, p553 - 565Journal Article, 2016, DOI , URL
• Medzhitov R, Belkaid Y, Davis M.M, Glimcher L, O'Neill L.A.J, Sallusto F, Immunology Gets out of the Box, Cell, 165, (4), 2016, p763 - 764Journal Article, 2016, DOI , URL
• Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572Journal Article, 2001, DOI , TARA - Full Text
• Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J.C, Tye H, Biette K, Jedlicka P, Brodsky K.S, Gerich M.E, Mack M, Robertson A.A.B, Cooper M.A, Furuta G.T, Dinarello C.A, O'Neill L.A, Eltzschig H.K, Masters S.L, McNamee E.N, Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome, Journal of Experimental Medicine, 214, (6), 2017, p1737 - 1752Journal Article, 2017, DOI , URL
• Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201Journal Article, 2017, DOI , TARA - Full Text
• Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 12, (7), 2018, p835-Journal Article, 2018, DOI , TARA - Full Text
• Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986Journal Article, 2017
• Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923-Journal Article, 2017, DOI , URL , TARA - Full Text
• Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017Journal Article, 2017, DOI , URL
• Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831Journal Article, 2017, DOI , URL
• Menon, D. and Innes, A. and Oakley, A.J. and Dahlstrom, J.E. and Jensen, L.M. and BrÃŒstle, A. and Tummala, P. and Rooke, M. and Casarotto, M.G. and Baell, J.B. and Nguyen, N. and Xie, Y. and Cuellar, M. and Strasser, J. and Dahlin, J.L. and Walters, M.A. and Burgio, G. and O'Neill, L.A.J. and Board, P.G., GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity, Scientific Reports, 7, (1), 2017Journal Article, 2017, DOI , URL , TARA - Full Text
• To, E.E. and Vlahos, R. and Luong, R. and Halls, M.L. and Reading, P.C. and King, P.T. and Chan, C. and Drummond, G.R. and Sobey, C.G. and Broughton, B.R.S. and Starkey, M.R. and Van Der Sluis, R. and Lewin, S.R. and Bozinovski, S. and O'Neill, L.A.J. and Quach, T. and Porter, C.J.H. and Brooks, D.A. and O'Leary, J.J. and Selemidis, S., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy, Nature Communications, 8, (1), 2017Journal Article, 2017, DOI , URL , TARA - Full Text
• Ryan, D.G. and O'Neill, L.A.J., Krebs cycle rewired for macrophage and dendritic cell effector functions, FEBS Letters, 591, (19), 2017, p2992-3006Journal Article, 2017, DOI , URL
• Chen, W. and Foo, S.-S. and Zaid, A. and Teng, T.-S. and Herrero, L.J. and Wolf, S. and Tharmarajah, K. and Vu, L.D. and Van Vreden, C. and Taylor, A. and Freitas, J.R. and Li, R.W. and Woodruff, T.M. and Gordon, R. and Ojcius, D.M. and Nakaya, H.I. and Kanneganti, T.-D. and O'Neill, L.A.J. and Robertson, A.A.B. and King, N.J. and Suhrbier, A. and Cooper, M.A. and Ng, L.F.P. and Mahalingam, S., Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation, Nature Microbiology, 2, (10), 2017, p1435-1445Journal Article, 2017, DOI , URL
• Kim, R.Y. and Pinkerton, J.W. and Essilfie, A.T. and Robertson, A.A.B. and Baines, K.J. and Brown, A.C. and Mayall, J.R. and Ali, M.K. and Starkey, M.R. and Hansbro, N.G. and Hirota, J.A. and Wood, L.G. and Simpson, J.L. and Knight, D.A. and Wark, P.A. and Gibson, P.G. and O'Neill, L.A.J. and Cooper, M.A. and Horvat, J.C. and Hansbro, P.M., Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma, American Journal of Respiratory and Critical Care Medicine, 196, (3), 2017, p283-297Journal Article, 2017, DOI , URL
• Nakhleh, J. and Christophides, G.K. and Osta, M.A. and O'Neill, L., The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae, Journal of Biological Chemistry, 292, (44), 2017, p18217-18226Journal Article, 2017, DOI , URL
• Thom, S.R. and Bhopale, V.M. and Yu, K. and Huang, W. and Kane, M.A. and Margolis, D.J. and O'Neill, L., Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability, Journal of Biological Chemistry, 292, (44), 2017, p18312-18324Journal Article, 2017, DOI , URL
• Wu, B.X. and Li, A. and Lei, L. and Kaneko, S. and Wallace, C. and Li, X. and Li, Z. and O'Neill, L., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis, Journal of Biological Chemistry, 292, (44), 2017, p18091-18097Journal Article, 2017, DOI , URL
• Khalid, H. and Mukherjee, S.P. and O'Neill, L. and Byrne, H.J., Structural dependence of in vitro cytotoxicity, oxidative stress and uptake mechanisms of poly(propylene imine) dendritic nanoparticles, Journal of Applied Toxicology, 36, (3), 2016, p464-473Journal Article, 2016, DOI , URL
• Williams, N.C. and O'Neill, L.A.J., A role for the krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation, Frontiers in Immunology, 9, (FEB), 2018, p00141-Journal Article, 2018, DOI , URL , TARA - Full Text
• Runtsch, M.C. and O'Neill, L.A.J., GOTcha: LncRNA-ACOD1 targets metabolism during viral infection, Cell Research, 28, (2), 2018, p137-138Journal Article, 2018, DOI , URL
• Kacprzyk, J. and Hughes, G.M. and Palsson-Mcdermott, E.M. and Quinn, S.R. and Puechmaille, S.J. and O'Neill, L.A.J. and Teeling, E.C., A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance, Acta Chiropterologica, 19, (2), 2017, p219-228Journal Article, 2017, DOI , URL
• McGettrick AF, Corcoran SE, Barry PJG, McFarland J, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LAJ, Nolan DP, The Trypanosoma brucei metabolite indolepyruvate decreases HIF-1 and glycolysis in macrophages as a mechanism of innate immune evasion, Proceedings of the National Academy of Sciences, U.S.A., 113, (48), 2016, pE7778 - E7787Journal Article, 2016, URL
• Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117Journal Article, 2018, DOI , URL
• Baardman, J. and Verberk, S.G.S. and Prange, K.H.M. and van Weeghel, M. and van der Velden, S. and Ryan, D.G. and WÃŒst, R.C.I. and Neele, A.E. and Speijer, D. and Denis, S.W. and Witte, M.E. and Houtkooper, R.H. and O'neill, L.A. and Knatko, E.V. and Dinkova-Kostova, A.T. and Lutgens, E. and de Winther, M.P.J. and Van den Bossche, J., A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia, Cell Reports, 25, (8), 2018, p2044-2052.e5Journal Article, 2018, DOI , URL , TARA - Full Text
• Murphy, M.P. and O'Neill, L.A.J., Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers, Cell, 174, (4), 2018, p780-784Journal Article, 2018, DOI , URL
• Angiari, S. and O'Neill, L.A., Dimethyl fumarate: Targeting glycolysis to treat MS, Cell Research, 28, (6), 2018, p613-615Journal Article, 2018, DOI , URL
• Perdisatt, L. and Moqadasi, S. and O'Neill, L. and Hessman, G. and Ghion, A. and Warraich, M.Q.M. and Casey, A. and O'Connor, C., Synthesis, characterisation and DNA intercalation studies of regioisomers of ruthenium (II) polypyridyl complexes, Journal of Inorganic Biochemistry, 182, 2018, p71-82Journal Article, 2018, DOI , URL
• O'Neill, L.A.J. and Zaslona, Z., Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3, Trends in Molecular Medicine, 24, (4), 2018, p335-337Journal Article, 2018, DOI , URL
• Kammoun, H.L. and Allen, T.L. and Henstridge, D.C. and Barre, S. and Coll, R.C. and Lancaster, G.I. and Cron, L. and Reibe, S. and Chan, J.Y. and Bensellam, M. and Laybutt, D.R. and Butler, M.S. and Robertson, A.A.B. and O'Neill, L.A. and Cooper, M.A. and Febbraio, M.A., Evidence against a role for NLRP3-driven islet inflammation in db/db mice, Molecular Metabolism, 10, 2018, p66-73Journal Article, 2018, DOI , URL , TARA - Full Text
• O'Neill, L.A. and Cooper, M.A., Canakinumab for Atherosclerotic Disease, The New England journal of medicine, 378, (2), 2018, p198-199Journal Article, 2018, DOI , URL
• Pankaj, S.K. and Bueno-Ferrer, C. and O'Neill, L. and Tiwari, B.K. and Bourke, P. and Cullen, P.J., Characterization of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Journal of Food Processing and Preservation, 41, (1), 2017Journal Article, 2017, DOI , URL
• Pankaj, S.K. and Bueno-Ferrer, C. and Misra, N.N. and O'Neill, L. and Bourke, P. and Cullen, P.J., Effects of cold plasma on surface, thermal and antimicrobial release properties of chitosan film, Journal of Renewable Materials, 5, (1), 2017, p14-20Journal Article, 2017, DOI , URL
• Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM., Circadian clock protein BMAL1 regulates IL-1ß in macrophages via NRF2., Proceedings of the National Academy of Sciences of the United States of America, 115, (36), 2018, pE8460-E8468Journal Article, 2018, DOI
• Schwartz C, Moran T, Saunders S.P, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O†Neill L, Irvine A.D, McKenzie A.N.J, Ogg G, Walsh P.T, Demengeot J, Fallon P.G, Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β, Allergy: European Journal of Allergy and Clinical Immunology, 2019, p1--Journal Article, 2019, DOI , URL , TARA - Full Text
• O†Neill L.A.J, Artyomov M.N, Itaconate: the poster child of metabolic reprogramming in macrophage function, Nature Reviews Immunology, 19, (5), 2019, p273 - 281Journal Article, 2019, DOI , URL
• Gul S.-E, O†neill L, Cassidy J, Naydenova I, Modified surface relief layer created by holographic lithography: Application to selective sodium and potassium sensing, Sensors (Switzerland), 19, (5), 2019Journal Article, 2019, DOI , URL
• Qasim Warraich M, Ghion A, Perdisatt L, O†Neill L, Casey A, O†Connor C, In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line, Drug and Chemical Toxicology, 2019Journal Article, 2019, DOI , URL
• Olagnier D, Brandtoft A.M, Gunderstofte C, Villadsen N.L, Krapp C, Thielke A.L, Laustsen A, Peri S, Hansen A.L, Bonefeld L, Thyrsted J, Bruun V, Iversen M.B, Lin L, Artegoitia V.M, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan D.G, Fitzgerald K.A, O†Neill L.A, Hollensen A.K, Damgaard C.K, de Paoli F, Bertram H.C, Jakobsen M.R, Poulsen T.B, Holm C.K, Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming, Nature Communications, 9, (1), 2018Journal Article, 2018, DOI , URL
• Gordon R, Albornoz E.A, Christie D.C, Langley M.R, Kumar V, Mantovani S, Robertson A.A.B, Butler M.S, Rowe D.B, O†Neill L.A, Kanthasamy A.G, Schroder K, Cooper M.A, Woodruff T.M, Inflammasome inhibition prevents -synuclein pathology and dopaminergic neurodegeneration in mice, Science Translational Medicine, 10, (465), 2018Journal Article, 2018, DOI , URL
• Hughes M.M, O†Neill L.A.J, Metabolic regulation of NLRP3, Immunological Reviews, 281, (1), 2018, p88 - 98Journal Article, 2018, DOI , URL
• Carroll R.G, ZasÅ'ona Z, Galván-Peña S, Koppe E.L, Sévin D.C, Angiari S, Triantafilou M, Triantafilou K, Modis L.K, O†Neill L.A, An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation, Journal of Biological Chemistry, 293, (15), 2018, p5509 - 5521Journal Article, 2018, DOI , URL
• Galván-Peña, S., Carroll, R.G., Newman, C., (...), Modis, L.K., O'Neill, L.A., Malonylation of GAPDH is an inflammatory signal in macrophages, Nature Communications, 10, (1), 2019, p338-Journal Article, 2019, URL , TARA - Full Text
• Hooftman, A. and O'Neill, L.A.J., The Immunomodulatory Potential of the Metabolite Itaconate, Trends in Immunology, 40, (8), 2019, p687-698Journal Article, 2019, DOI , URL
• Ketelhuth, D.F.J. and Lutgens, E. and BÀck, M. and Binder, C.J. and Van den Bossche, J. and Daniel, C. and Dumitriu, I.E. and Hoefer, I. and Libby, P. and O'Neill, L. and Weber, C. and Evans, P.C., Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology, Cardiovascular research, 115, (9), 2019, p1385-1392Journal Article, 2019, DOI , URL , TARA - Full Text
• Geiger, S.S. and Curtis, A.M. and O'Neill, L.A.J. and Siegel, R.M., Daily variation in macrophage phagocytosis is clock-independent and dispensable for cytokine production, Immunology, 157, (2), 2019, p122-136Journal Article, 2019, DOI , URL , TARA - Full Text
• O'Neill, L. and Perdisatt, L. and O'Connor, C., Structure-property relationships for a Series of Ruthenium(II) polypyridyl complexes elucidated through raman spectroscopy, Journal of Spectroscopy, 2018, (3827130), 2018Journal Article, 2018, DOI , URL
• A. Mansell, A. Reinicke, D. M. Worrall and L. A. O'Neill, The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4, FEBS letters, 508, (3), 2001, p313-317Journal Article, 2001, DOI , URL
• L. A. O'Neill and C. A. Dinarello, The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense, Immunology today, 21, (5), 2000, p206-209Journal Article, 2000, DOI , URL
• E. M. Palsson-McDermott and L. A. O'Neill, Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4, Immunology, 113, (2), 2004, p153-62Journal Article, 2004, DOI , TARA - Full Text
• M. P. Hardy and L. A. O'Neill, The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory, The Journal of biological chemistry, 279, (26), 2004, p27699-708Journal Article, 2004, DOI , TARA - Full Text
• C. Wietek, S. M. Miggin, C. A. Jefferies and L. A. O'Neill, Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, The Journal of Biological Chemistry, 278, (51), 2003, p50923-50931Journal Article, 2003, DOI , TARA - Full Text
• A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451Journal Article, 2003, DOI , TARA - Full Text
• C. A. Jefferies, S. Doyle, C. Brunner, A. Dunne, E. Brint, C. Wietek, E. Walch, T. Wirth and L. A. O'Neill, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4, The Journal of Biological Chemistry, 278, (28), 2003, p26258-64Journal Article, 2003, DOI , TARA - Full Text
• E. P. McDermott and L. A. O'Neill, Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1, The Journal of Biological Chemistry, 277, (10), 2002, p7808-7815Journal Article, 2002, DOI , TARA - Full Text
• A. Mansell, N. Khelef, P. Cossart and L. A. O'Neill, Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt, The Journal of Biological Chemistry, 276, (47), 2001, p43597-43603Journal Article, 2001, DOI , TARA - Full Text
• E. M. Palsson, M. Popoff, M. Thelestam and L. A. O'Neill, Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1, The Journal of Biological Chemistry, 275, (11), 2000, p7818-7825Journal Article, 2000, URL , TARA - Full Text
• C. A. Jefferies and L. A. O'Neill, Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression, The Journal of Biological Chemistry, 275, (5), 2000, p3114-3120Journal Article, 2000, URL , TARA - Full Text
• M. P. Boland, K. A. Fitzgerald and L. A. O'Neill, Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells, The Journal of Biological Chemistry, 275, (33), 2000, p25231-25238Journal Article, 2000, DOI , TARA - Full Text
• M. P. Boland and L. A. O'Neill, Ceramide activates NFkappaB by inducing the processing of p105, The Journal of Biological Chemistry, 273, (25), 1998, p15494-15500Journal Article, 1998, DOI , URL , TARA - Full Text
• A. G. Bowie, P. N. Moynagh and L. A. O'Neill, Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells, The Journal of biological chemistry, 272, (41), 1997, p25941-25950Journal Article, 1997, URL
• M. P. Boland, S. J. Foster and L. A. O'Neill, Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells, The Journal of Biological Chemistry, 272, (20), 1997, p12952-12960Journal Article, 1997, DOI , URL , TARA - Full Text
• M. A. O'Connell, R. Cleere, A. Long, L. A. O'Neill and D. Kelleher, Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78, The Journal of biological chemistry, 270, (13), 1995, p7399-404Journal Article, 1995, DOI , URL , TARA - Full Text
• L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9Journal Article, 2003, DOI , URL
• A. G. Bowie and L. A. O'Neill, Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase, Journal of Immunology, 165, (12), 2000, p7180-7188Journal Article, 2000, TARA - Full Text
• K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology , 164, (4), 2000, p2053-2063Journal Article, 2000, URL
• E. J. Ryan, E. McNeela, M. Pizza, R. Rappuoli, L. O'Neill and K. H. Mills, Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity, Journal of Immunology (Baltimore, Md, 165, (10), 2000, p5750-9Journal Article, 2000, TARA - Full Text
• K. A. Fitzgerald and L. A. O'Neill, Characterization of CD44 induction by IL-1: a critical role for Egr-1, Journal of Immunology , 162, (8), 1999, p4920-4927Journal Article, 1999, URL , TARA - Full Text
• A. Bowie and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products, Journal of Leukocyte Biology, 67, (4), 2000, p508-514Journal Article, 2000, URL , TARA - Full Text
• D. R. Caffrey, L. A. O'Neill and D. C. Shields, The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades, Journal of Molecular Evolution, 49, (5), 1999, p567-582Journal Article, 1999, DOI , URL
• M. P. Hardy, G. A. F. Mc and L. A. O'Neill, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, The Biochemical journal, 380, (Pt 1), 2004, p83-93Journal Article, 2004, URL
• P. N. Moynagh, D. C. Williams and L. A. O'Neill, Interleukin-1 activates transcription factor NF kappa B in glial cells, The Biochemical Journal, 294 , (2), 1993, p343-347Journal Article, 1993, URL , TARA - Full Text
• A. Bowie and L. A. O'Neill, Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries, Biochemical pharmacology, 59, (1), 2000, p13-23Journal Article, 2000, DOI , URL
• L. A. O'Neill, The role of MyD88-like adapters in Toll-like receptor signal transduction, Biochemical Society Transactions, 31, (Pt 3), 2003, p643-637Journal Article, 2003, URL
• L. O'Neill, The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence, Biochemical Society Transactions, 28, (5), 2000, p557-563Journal Article, 2000, URL
• M. P. Boland, S. J. Foster and L. A. O'Neill, Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event, Biochemical Society Transactions, 24, (1), 1996, p1SJournal Article, 1996, URL
• E. F. Dunn, N. J. Gay, A. F. Bristow, D. P. Gearing, L. A. O'Neill and X. Y. Pei, High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity, Biochemistry, 42, (37), 2003, p10938-10944Journal Article, 2003, DOI , URL
• C. Greene and L. O'Neill, Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA, Biochimica et biophysica acta, 1451, (1), 1999, p109-121Journal Article, 1999, DOI , URL
• B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, M. Lawler, L. O'Neill, D. Kelleher, H. P. Schwarz and O. P. Smith, Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, 110, (1), 2000, p130-134Journal Article, 2000, DOI , URL
• A. Mansell, L. Braun, P. Cossart and L. A. O'Neill, A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages, Cellular microbiology, 2, (2), 2000, p127-136Journal Article, 2000, DOI , URL
• J. M. O'Sullivan, A. Gribbin, J. Taylor, L. O'Neill, S. Cosgrove and J. G. Armstrong, Complications of treatment with local field external beam radiotherapy for localized prostate cancer, Clinical Oncology (Royal College of Radiologists (Great Britain)), 12, (4), 2000, p217-221Journal Article, 2000, DOI , URL
• L. A. O'Neill, Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases, Current opinion in pharmacology, 3, (4), 2003, p396-403Journal Article, 2003, DOI , URL
• S. G. Ward and L. A. O'Neill, Spotlight on new anti-inflammatory drug targets in the immune system, Current opinion in pharmacology, 3, (4), 2003, p391-5Journal Article, 2003, DOI , URL
• L. A. O'Neill, Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily, Current Topics in Microbiology and Immunology, 270, 2002, p47-61Journal Article, 2002, URL
• J. S. Matthews and L. A. O'Neill, Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1, Cytokine, 11, (9), 1999, p643-655Journal Article, 1999, DOI , URL
• M. A. O'Connell, D. Kelleher, R. M. Liskamp, N. Hall, L. A. O'Neill and A. Long, TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes, Cytokine, 9, (2), 1997, p83-92Journal Article, 1997, DOI , URL
• K. A. Fitzgerald and L. A. O'Neill, The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence, Microbes and infection / Institut Pasteur, 2, (8), 2000, p933-943Journal Article, 2000, DOI , URL
• L. A. O'Neill, Wanted: a molecular basis for specificity in toll-like receptor signal transduction, Molecular cell, 10, (5), 2002, p969-971Journal Article, 2002, DOI , URL
• C. Jefferies, A. Bowie, G. Brady, E. L. Cooke, X. Li and L. A. O'Neill, Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1, Molecular and Cellular Biology, 21, (14), 2001, p4544-4552Journal Article, 2001, DOI
• L. A. O'Neill, How NOD-ing off leads to Crohn disease, Nature immunology, 5, (8), 2004, p776-8Journal Article, 2004, DOI , URL
• L. A. O'Neill, SIGIRR puts the brakes on Toll-like receptors., Nature immunology, 4, (9), 2003, p823-824Journal Article, 2003, DOI , URL
• E. K. Brint, D. Xu, H. Liu, A. Dunne, A. N. McKenzie, L. A. O'Neill and F. Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nature immunology, 5, (4), 2004, p373-379Journal Article, 2004, DOI , URL
• L. A. O'Neill, Z. Brown and S. G. Ward, Toll-like receptors in the spotlight, Nature immunology, 4, (4), 2003, p299Journal Article, 2003, DOI , URL
• K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83Journal Article, 2001, DOI , URL
• A. N. Coogan, L. A. O'Neill and J. J. O'Connor, The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro, Neuroscience, 93, (1), 1999, p57-69Journal Article, 1999, DOI , URL
• A. Bowie, E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower and L. A. O'Neill, A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling, Proceedings of the National Academy of Sciences of the United States of America, 97, (18), 2000, p10162-10167Journal Article, 2000, DOI , TARA - Full Text
• D. R. Caffrey, L. A. O'Neill and D. C. Shields, A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways, Protein Science, 9, (4), 2000, p655-670Journal Article, 2000, URL , TARA - Full Text
• A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3Review, 2003, DOI , URL
• L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2000, (44), 2000, pRE1Journal Article, 2000, DOI , URL
• L. A. O'Neill, Immunology. After the toll rush, Science, 303, (5663), 2004, p1481-2Journal Article, 2004, DOI , URL
• P. J. Hertzog, L. A. O'Neill and J. A. Hamilton, The interferon in TLR signaling: more than just antiviral, Trends in Immunology, 24, (10), 2003, p534-539Journal Article, 2003, DOI , URL
• L. A. O'Neill, K. A. Fitzgerald and A. G. Bowie, The Toll-IL-1 receptor adaptor family grows to five members, Trends in immunology, 24, (6), 2003, p286-90Journal Article, 2003, DOI , URL
• V. Corrigall and L. A. O'Neill, Using immunotherapy to treat rheumatic diseases, Trends in immunology, 23, (8), 2002, p383-384Journal Article, 2002, DOI , URL
• L. A. O'Neill, Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?, Trends in immunology, 23, (6), 2002, p296-300Journal Article, 2002, DOI , URL
• E. Dunn, J. E. Sims, M. J. Nicklin and L. A. O'Neill, Annotating genes with potential roles in the immune system: six new members of the IL-1 family, Trends in Immunology, 22, (10), 2001, p533-536Journal Article, 2001, DOI , URL
• O'Neill, LAJ, Toll-like receptors and the danger hypothesis, Trends in Immunology, 22, (8), 2001, p421Journal Article, 2001, DOI , URL
• L. O'Neill, Specificity in the innate response: pathogen recognition by Toll-like receptor combinations, Trends in immunology, 22, (2), 2001, p70Journal Article, 2001, DOI , URL
• C. A. Jefferies and L. A. O'Neill, Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?, Immunology letters, 92, (38018), 2004, p15-22Journal Article, 2004, DOI , URL
• A. F. McGettrick and L. A. O'Neill, The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction, Mol Immunol, 41, (6-7), 2004, p577-82Journal Article, 2004, DOI , URL
• Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Z. Zas³ona , E. Flis, M.M. Wilk, R.G. Carroll, E.M. Palsson-McDermott, M.M. Hughes, C. Diskin, K. Banahan, D.G. Ryan, A. Hooftman, A. Misiak, J. Kearney, G. Lochnit, W. Bertrams, T. Greulich, B. Schmeck, O.J. McElvaney, K.H.G. Mills, E.C. Lavelle, M. Wygrecka, E.M. Creagh & L.A.J. O'Neill , Caspase-11 promotes allergic airway inflammation, Nature Communications, 2020Journal Article, 2020, URL , TARA - Full Text
• Angiari, S. and Runtsch, M.C. and Sutton, C.E. and Palsson-McDermott, E.M. and Kelly, B. and Rana, N. and Kane, H. and Papadopoulou, G. and Pearce, E.L. and Mills, K.H.G. and O'Neill, L.A.J., Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity, Cell Metabolism, 31, (2), 2020, p391-405.e8Journal Article, 2020, DOI , URL , TARA - Full Text
• Zaslona Z, Flis E, Nulty C, Kearney J, Fitzgerald R, Douglas AR, McNamara D, Smith S, O'Neill LAJ, Creagh EM., Caspase-4: A Therapeutic Target for Peptic Ulcer Disease, Immunohorizons, 4, (10), 2021, p627 - 633Journal Article, 2021, DOI
• Liong S, Oseghale O, To EE, Brassington K, Erlich JR, Luong R, Liong F, Brooks R, Martin C, O'Toole S, Vinh A, O'Neill LAJ, Bozinovski S, Vlahos R, Papagianis PC, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2020Journal Article, 2020, DOI , TARA - Full Text
• Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E Corcoran, Marah C Runisch, Chris Ling, Melanie C Ruzek, Peter F Slivka, Anne F McGettrick, Kathy Banahan, Mark M Hughes, Alan D Irvine, Roman Fischer, Luke A J O'Neill, The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation, Cell Metabolism, 2020Journal Article, 2020, DOI , TARA - Full Text
• Mark M Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C Runtsch, Anne F McGettrick, Caroline E Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G Casarotto, Jane E Dahlstrom, Eva M Palsson-McDermott, Sinead C Corr, Kingston H G Mills, Roger J S Preston, Luke A J O'Neill, Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 2019Journal Article, 2019, DOI , TARA - Full Text
• Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O†Neill, L.A. and Pickkers, P. and van der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and van der Meer, J.W.M. and van de Veerdonk, F.L. and Dinarello, C.A., Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790), Nature Immunology, 22, (2), 2021, p254 -Journal Article, 2021, DOI , URL , TARA - Full Text
• Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20Journal Article, 1996, DOI , URL
• van den Hoogen, B. and Santoni, A. and Sciumé, G. and Bowie, A. and O'Farrelly, C. and O'Neill, L. and Anthonsen, M. and Pardali, K. and Young, S. and Bergthaler, A. and Manel, N. and Zahn, R. and Kikkert, M. and Snijder, E. and van Kuppeveld, F. and Fouchier, R. and Hiscott, J., Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network, Virus Research, 287, (198094), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Ryan, D.G. and Frezza, C. and O'Neill, L.A., TCA cycle signalling and the evolution of eukaryotes, Current Opinion in Biotechnology, 68, 2021, p72-88Journal Article, 2021, DOI , URL
• Weiss, H.J. and O'Neill, L.A.J., Bridging the gap â€" a new role for STAT3 in TLR4-mediated metabolic reprogramming, Immunology and Cell Biology, 99, (2), 2021, p122-125Journal Article, 2021, DOI , URL , TARA - Full Text
• Diskin, C. and Ryan, T.A.J. and O'Neill, L.A.J., Modification of Proteins by Metabolites in Immunity, Immunity, 54, (1), 2021, p19-31Journal Article, 2021, DOI , URL
• McGettrick, A.F. and O'Neill, L.A.J., The Role of HIF in Immunity and Inflammation, Cell Metabolism, 32, (4), 2020, p524-536Journal Article, 2020, DOI , URL
• Hams, E. and Roberts, J. and Bermingham, R. and Hogan, A.E. and O'Shea, D. and O'Neill, L. and Fallon, P.G., Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity, Frontiers in Immunology, 11, (1966), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• ZasÅ'ona, Z. and O'Neill, L.A.J., Cytokine-like Roles for Metabolites in Immunity, Molecular Cell, 78, (5), 2020, p814-823Journal Article, 2020, DOI , URL
• Runtsch, M.C. and O'Neill, L.A.J., Pseudomonas Persists by Feeding off Itaconate, Cell Metabolism, 31, (6), 2020, p1045-1047Journal Article, 2020, DOI , URL
• To, E.E. and O'Leary, J.J. and O'Neill, L.A.J. and Vlahos, R. and Bozinovski, S. and Porter, C.J.H. and Brooks, R.D. and Brooks, D.A. and Selemidis, S., Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses, Antioxidants and Redox Signaling, 32, (13), 2020, p982-992Journal Article, 2020, DOI , URL , TARA - Full Text
• Ryan, D.G. and O'Neill, L.A.J., Krebs Cycle Reborn in Macrophage Immunometabolism, Annual Review of Immunology, 38, 2020, p289-313Journal Article, 2020, DOI , URL
• Williams, N.C. and O'Neill, L.A., ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming, Trends in Immunology, 41, (2), 2020, p93-94Journal Article, 2020, DOI , URL
• Barton, S.J. and O'Dwyer, K. and Butler, M. and Dignam, A. and Byrne, H.J. and O'Neill, L. and Hennelly, B.M., Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples, Analytical Methods, 11, (47), 2019, p6023-6032Journal Article, 2019, DOI , URL , TARA - Full Text
• McElvaney, O.J. and Zaslona, Z. and Becker-Flegler, K. and Palsson-McDermott, E.M. and Boland, F. and Gunaratnam, C. and Gulbins, E. and O'Neill, L.A. and Reeves, E.P. and McElvaney, N.G., Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosis, American Journal of Respiratory and Critical Care Medicine, 200, (11), 2019, p1381-1391Journal Article, 2019, DOI , URL
• BÀckhed, F. and Bugianesi, E. and Christofk, H. and Dikic, I. and Gupta, R. and Mair, W.B. and O†Neill, L.A.J. and Ralser, M. and Sabatini, D.M. and Tschöp, M., The next decade of metabolism, Nature Metabolism, 1, (1), 2019, p2-4Journal Article, 2019, DOI , URL
• Lynne A. Kelly, Mary I. O"Dea, Zunera Zareen, Ashanty M. Melo, Ellen McKenna, Tammy Strickland, Victoria Mc Eneaney, Veronica Donoghue, Geraldine Boylan, Deirdre Sweetman, John Butler, Claudine Vavasseur, Jan Miletin, Afif F.El"Khuffash, Luke A.J. O"Neill, John J. O"Leary, Eleanor J. Molloy, Altered Inflammasome activation in Neonatal Encephalopathy persists in Childhood, Clinical & Experimental Immunology, 2021Journal Article, 2021
• Williams, N.C. and Ryan, D.G. and Costa, A.S.H. and Mills, E.L. and Jedrychowski, M.P. and Cloonan, S.M. and Frezza, C. and O'Neill, L.A., Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages, Journal of Biological Chemistry, 298, (2), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Pinkerton, J.W. and Kim, R.Y. and Brown, A.C. and Rae, B.E. and Donovan, C. and Mayall, J.R. and Carroll, O.R. and Khadem Ali, M. and Scott, H.A. and Berthon, B.S. and Baines, K.J. and Starkey, M.R. and Kermani, N.Z. and Guo, Y.-K. and Robertson, A.A.B. and O'Neill, L.A.J. and Adcock, I.M. and Cooper, M.A. and Gibson, P.G. and Wood, L.G. and Hansbro, P.M. and Horvat, J.C., Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma, Journal of Allergy and Clinical Immunology, 149, (4), 2022, p1270-1280Journal Article, 2022, DOI , URL
• Ryan, T.A.J. and Preston, R.J.S. and O†Neill, L.A.J., Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants, Biochemical Journal, 479, (6), 2022, p731-750Journal Article, 2022, DOI , URL
• Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8Journal Article, 2022, DOI , URL
• Ryan, D.G. and Knatko, E.V. and Casey, A.M. and Hukelmann, J.L. and Dayalan Naidu, S. and Brenes, A.J. and Ekkunagul, T. and Baker, C. and Higgins, M. and Tronci, L. and Nikitopolou, E. and Honda, T. and Hartley, R.C. and O'Neill, L.A.J. and Frezza, C. and Lamond, A.I. and Abramov, A.Y. and Arthur, J.S.C. and Cantrell, D.A. and Murphy, M.P. and Dinkova-Kostova, A.T., Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response, iScience, 25, (2), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Peace, C.G. and O†Neill, L.A.J., The role of itaconate in host defense and inflammation, Journal of Clinical Investigation, 132, (2), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Toller-Kawahisa, J.E. and O†Neill, L.A.J., Creating ATP via creatine kinase B for NLRP3 activation, Nature Immunology, 2022Journal Article, 2022, DOI , URL
• Baldanti, F. and Ganguly, N.K. and Wang, G. and Möckel, M. and O†Neill, L.A. and Renz, H. and dos Santos Ferreira, C.E. and Tateda, K. and Van Der Pol, B., Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future, Critical Reviews in Clinical Laboratory Sciences, 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Hooftman, A. and O'Neill, L.A.J., Nanoparticle asymmetry shapes an immune response, Nature, 601, (7893), 2022, p323-325Journal Article, 2022, DOI , URL
• Yin, M. and O†Neill, L.A.J., The role of the electron transport chain in immunity, FASEB Journal, 35, (12), 2021Journal Article, 2021, DOI , URL
• Umar, S. and Palasiewicz, K. and Volin, M.V. and Romay, B. and Rahat, R. and Tetali, C. and Arami, S. and Guma, M. and Ascoli, C. and Sweiss, N. and Zomorrodi, R.K. and O†Neill, L.A.J. and Shahrara, S., Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types, Cellular and Molecular Life Sciences, 78, (23), 2021, p7693-7707Journal Article, 2021, DOI , URL
• Diskin, C. and Zotta, A. and Corcoran, S.E. and Tyrrell, V.J. and Zaslona, Z. and O'Donnell, V.B. and O'Neill, L.A.J., 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages, Journal of immunology (Baltimore, Md. : 1950), 207, (10), 2021, p2561-2569Journal Article, 2021, DOI , URL
• Diskin, C. and Corcoran, S.E. and Tyrrell, V.J. and McGettrick, A.F. and Zaslona, Z. and O'Donnell, V.B. and Nolan, D.P. and O'Neill, L.A.J., The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2, Journal of immunology (Baltimore, Md. : 1950), 207, (10), 2021, p2551-2560Journal Article, 2021, DOI , URL
• Santarsiero, A. and Convertini, P. and Todisco, S. and Pierri, C.L. and De Grassi, A. and Williams, N.C. and Iacobazzi, D. and De Stefano, G. and O†Neill, L.A.J. and Infantino, V., ACLY nuclear translocation in human macrophages drives proinflammatory gene expression by NF-κB acetylation, Cells, 10, (11), 2021Journal Article, 2021, DOI , URL
• Buckley, C.D. and Chernajovsky, L. and Chernajovsky, Y. and Modis, L.K. and O†Neill, L.A. and Brown, D. and Connor, R. and Coutts, D. and Waterman, E.A. and Tak, P.P., Immune-mediated inflammation across disease boundaries: breaking down research silos, Nature Immunology, 22, (11), 2021, p1344-1348Journal Article, 2021, DOI , URL
• Zotta, A. and Hooftman, A. and O†Neill, L.A.J., SARS-CoV-2 targets MAVS for immune evasion, Nature Cell Biology, 23, (7), 2021, p682-683Journal Article, 2021, DOI , URL
• Divangahi, M. and Aaby, P. and Khader, S.A. and Barreiro, L.B. and Bekkering, S. and Chavakis, T. and van Crevel, R. and Curtis, N. and DiNardo, A.R. and Dominguez-Andres, J. and Duivenvoorden, R. and Fanucchi, S. and Fayad, Z. and Fuchs, E. and Hamon, M. and Jeffrey, K.L. and Khan, N. and Joosten, L.A.B. and Kaufmann, E. and Latz, E. and Matarese, G. and van der Meer, J.W.M. and Mhlanga, M. and Moorlag, S.J.C.F.M. and Mulder, W.J.M. and Naik, S. and Novakovic, B. and O†Neill, L. and Ochando, J. and Ozato, K. and Riksen, N.P. and Sauerwein, R. and Sherwood, E.R. and Schlitzer, A. and Schultze, J.L. and Sieweke, M.H. and Benn, C.S. and Stunnenberg, H. and Sun, J. and van de Veerdonk, F.L. and Weis, S. and Williams, D.L. and Xavier, R. and Netea, M.G., Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes (Nature Immunology, (2021), 22, 1, (2-6), 10.1038/s41590-020-00845-6), Nature Immunology, 22, (7), 2021, p928Journal Article, 2021, DOI , URL
• Tummala, P. and Rooke, M. and Dahlstrom, J.E. and Takahashi, S. and Casarotto, M.G. and Fernando, N. and Hughes, M.M. and O'neill, L.A.J. and Board, P.G., Glutathione transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation, Carcinogenesis, 42, (6), 2021, p853-863Journal Article, 2021, DOI , URL
• Day, E.A. and O†Neill, L.A.J., Targeting mitochondria to beat HIV-1, Nature Immunology, 22, (4), 2021, p398-399Journal Article, 2021, DOI , URL
• Peace, C.G. and O'Neill, L.A.J., Ironing Out Vaccine Efficacy, Med, 2, (2), 2021, p113-114Journal Article, 2021, DOI , URL
• Hooftman, A. and O'Neill, L.A.J., Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19?, Current Research in Pharmacology and Drug Discovery, 2, (100048), 2021Journal Article, 2021, DOI , URL
• Divangahi, M. and Aaby, P. and Khader, S.A. and Barreiro, L.B. and Bekkering, S. and Chavakis, T. and van Crevel, R. and Curtis, N. and DiNardo, A.R. and Dominguez-Andres, J. and Duivenwoorden, R. and Fanucchi, S. and Fayad, Z. and Fuchs, E. and Hamon, M. and Jeffrey, K.L. and Khan, N. and Joosten, L.A.B. and Kaufmann, E. and Latz, E. and Matarese, G. and van der Meer, J.W.M. and Mhlanga, M. and Moorlag, S.J.C.F.M. and Mulder, W.J.M. and Naik, S. and Novakovic, B. and O†Neill, L. and Ochando, J. and Ozato, K. and Riksen, N.P. and Sauerwein, R. and Sherwood, E.R. and Schlitzer, A. and Schultze, J.L. and Sieweke, M.H. and Benn, C.S. and Stunnenberg, H. and Sun, J. and van de Veerdonk, F.L. and Weis, S. and Williams, D.L. and Xavier, R. and Netea, M.G., Trained immunity, tolerance, priming and differentiation: distinct immunological processes, Nature Immunology, 22, (1), 2021, p2-6Journal Article, 2021, DOI , URL
• Murphy, M.P. and O†Neill, L.A.J., How should we talk about metabolism?, Nature Immunology, 21, (7), 2020, p713-715Journal Article, 2020, DOI , URL
• O†Neill, L.A.J. and Netea, M.G., BCG-induced trained immunity: can it offer protection against COVID-19?, Nature Reviews Immunology, 20, (6), 2020, p335-337Journal Article, 2020, DOI , URL
• PÃ¥lsson-McDermott, E.M. and O†Neill, L.A.J., Targeting immunometabolism as an anti-inflammatory strategy, Cell Research, 30, (4), 2020, p300-314Journal Article, 2020, DOI , URL
• Weiss, H.J. and O†Neill, L.A.J., Of Flies and Menâ€"The Discovery of TLRs, Cells, 11, (19), 2022Journal Article, 2022, DOI , URL
• Ryan, T.A.J. and O'Neill, L.A.J., Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities, European Journal of Immunology, 52, (7), 2022, p1024-1034Journal Article, 2022, DOI , URL
• McGettrick, A.F. and O†Neill, L.A.J., The itaconate family of immunomodulators grows, Nature Metabolism, 4, (5), 2022, p499-500Journal Article, 2022, DOI , URL
• Daniel Johnston, A role for microRNA-21 in the regulation of gastrointestinal health and disease, Trinity College Dublin, 2017Thesis, 2017, URL
• O'NEILL LA et al., PCT application - "A46R - Orthopoxvirus, genes and products thereof"., 2003Patent, 2003
• O'NEILL LA et al., PCT application - "A52R - Orthopoxvirus, genes and products thereof", 2003Patent, 2003
• O'NEILL LUKE A J (Trinity College Dublin); SIMS JOHN E (Immunex); BIRD TIMOTHY A (Immunex), MyD88 adaptor-like proteins, 2004, WO 01/088137Patent, 2004
• O'NEILL LA et al, PCT application - 'Assays relating to Toll-like receptor-4 and compositions for modulating same', 2005Patent, 2005
• O'NEILL LA et al, PCT application: 'TLR14 - a novel Toll-like receptor', 2005Patent, 2005
• Liew, E, Xu, D, Brint, E, O'Neill, LA, Negative regulation of TLR signalling, Nature Rev. Immunol., 5, (6), 2005, p446 - 458Journal Article, 2005, DOI , URL
• Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, J Biol Chem., 280, (25), 2005, p23496 - 23501Journal Article, 2005, DOI , URL , TARA - Full Text
• Dunne A and O'Neill LA, Adaptor usage and Toll-like receptor signaling specificity, FEBS Lett., 579, (15), 2005Review, 2005, DOI , URL
• Panayi, G and O'Neill LA, Targetting innate and adaptive immunity in arthritis, New England Jounral of Medicine, 2005Journal Article, 2005
• Day EA, O'Neill LAJ., Protein targeting by the itaconate family in immunity and inflammation., The Biochemical journal, 479, (24), 2022, p2499-2510Journal Article, 2022, DOI
• Toller-Kawahisa, J.E. and O'Neill, L.A.J., How neutrophil metabolism affects bacterial killing, Open Biology, 12, (11), 2022Journal Article, 2022, DOI , URL
• Jones, S.A. and Bryant, C. and Lloyd, C.M. and Mcinnes, I. and O'neill, L., A Vision for Cytokine Biology with 20/20 Clarity, Function, 2, (1), 2021Journal Article, 2021, DOI , URL
• McGettrick AF, O'Neill LA., Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite., Current opinion in immunology, 80, 2023, p102268Journal Article, 2023, DOI
• Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ., Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. , Nature, 2023, p32Journal Article, 2023, DOI , TARA - Full Text
• Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211Journal Article, 2002, DOI , TARA - Full Text
• Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and O†Brien, E.C. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and O†Donnell, J.S. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and O†Neill, L.A.J., Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (Nature Communications, (2023), 14, 1, (3513), 10.1038/s41467-023-39174-1), Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , URL , TARA - Full Text
• Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O'Neill LAJ., 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development., Journal of immunology (Baltimore, Md. : 1950), 212, (1), 2024, p13-23Journal Article, 2024, DOI
• Peace C.G, O'Carroll S.M, O'Neill L.A.J, Fumarate hydratase as a metabolic regulator of immunity, Trends in Cell Biology, 34, (6), 2024, p442 - 450Journal Article, 2024, DOI
• O'Carroll S.M, Henkel F.D.R, O'Neill L.A.J, Metabolic regulation of type I interferon production, Immunological Reviews, 323, (1), 2024, p276 - 287Journal Article, 2024, DOI , TARA - Full Text
• Carpenter S, O'Neill L.A.J, From periphery to center stage: 50 years of advancements in innate immunity, Cell, 187, (9), 2024, p2030 - 2051Journal Article, 2024, DOI , TARA - Full Text
• Zotta A, O'Neill L.A.J, Yin M, Unlocking potential: the role of the electron transport chain in immunometabolism, Trends in Immunology, 45, (4), 2024, p259 - 273Journal Article, 2024, DOI , TARA - Full Text
• Min Y, O'Neill L.A.J, Itaconate boosts malaria via induction of PD-L1, Cell Metabolism, 36, (3), 2024, p457 - 458Journal Article, 2024, DOI
• Murphy M.P, O†Neill L.A.J, A break in mitochondrial endosymbiosis as a basis for inflammatory diseases, Nature, 626, (7998), 2024, p271 - 279Journal Article, 2024, DOI
• Wright O, Harris A, Nguyen V.D, Zhou Y, Durand M, Jayyaratnam A, Gormley D, O†Neill L.A.J, Triantafilou K, Nichols E.M, Booty L.M, C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages, Cells, 12, (23), 2023Journal Article, 2023, DOI , TARA - Full Text
• Horvat J.C, Kim R.Y, Weaver N, Augood C, Brown A.C, Donovan C, Dupre P, Gunawardhana L, Mayall J.R, Hansbro N.G, Robertson A.A.B, O†Neill L.A.J, Cooper M.A, Holliday E.G, Hansbro P.M, Gibson P.G, Characterization and inhibition of inflammasome responses in severe and non-severe asthma, Respiratory Research, 24, (1), 2023Journal Article, 2023, DOI , TARA - Full Text
• Toller-Kawahisa J.E, Hiroki C.H, Silva C.M.S, Nascimento D.C, Públio G.A, Martins T.V, Damasceno L.E.A, Veras F.P, Viacava P.R, Sukesada F.Y, Day E.A, Zotta A, Ryan T.A.J, Moreira da Silva R, Cunha T.M, Lopes N.P, Cunha F.Q, O†Neill L.A.J, Alves-Filho J.C, The metabolic function of pyruvate kinase M2 regulates reactive oxygen species production and microbial killing by neutrophils, Nature Communications, 14, (1), 2023Journal Article, 2023, DOI , TARA - Full Text
• Ribó-Molina P, Weiss H.J, Susma B, van Nieuwkoop S, Persoons L, Zheng Y, Ruzek M, Daelemans D, Fouchier R.A.M, O'Neill L.A.J, van den Hoogen B.G, 4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1, Journal of Virology, 97, (10), 2023Journal Article, 2023, DOI , TARA - Full Text
• Diskin C, Day E.A, Henry Ã".C, Toller-Kawahisa J.E, O†Neill L.A.J, 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2, Journal of Immunology, 211, (6), 2023, p1032 - 1041Journal Article, 2023, DOI , TARA - Full Text
• Henkel F.D.R, O'Neill L.A.J, NLRP12 drives PANoptosis in response to heme, Trends in Immunology, 44, (8), 2023, p574 - 576Journal Article, 2023, DOI
• Yin M, Marrone L, Peace C.G, O†Neill L.A.J, NLRP3, the inflammasome and COVID-19 infection, QJM: An International Journal of Medicine, 116, (7), 2023, p502 - 507Journal Article, 2023, DOI , TARA - Full Text
• Cable J, Rathmell J.C, Pearce E.L, Ho P.-C, Haigis M.C, Mamedov M.R, Wu M.-J, Kaech S.M, Lynch L, Febbraio M.A, Bapat S.P, Hong H.S, Zou W, Belkaid Y, Sullivan Z.A, Keller A, Wculek S.K, Green D.R, Postic C, Amit I, Benitah S.A, Jones R.G, Reina-Campos M, Torres S.V, Beyaz S, Brennan D, O'Neill L.A.J, Perry R.J, Brenner D, Immunometabolism at the crossroads of obesity and cancerâ€"a Keystone Symposia report, 1523, (1), 2023, 38 - 50Miscellaneous, 2023, DOI , TARA - Full Text
• Ryan T.A.J, O†Neill L.A.J, An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation, Cells, 12, (5), 2023Journal Article, 2023, DOI , TARA - Full Text
• Carpenter, S. and O'Neill, L.A.J., Erratum: From periphery to center stage: 50 years of advancements in innate immunity (Cell (2024) 187(9) (2030â€"2051), (S0092867424003520), (10.1016/j.cell.2024.03.036)), Cell, 187, (16), 2024, p4429-4430Journal Article, 2024, DOI , URL
• Brady G, Boggan L, Bowie A and O'Neill LA, Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1, Journal of Biological Chemistry, 280, (35), 2005, p30723 - 30734Journal Article, 2005, DOI , TARA - Full Text
• O'Neill LA, TLRs play good cop bad cop in lung, Nature Medicine, 11, (11), 2005, p1161 - 1162Journal Article, 2005, DOI , URL
• Luke O'Neill and Elisabeth Brint (editors), Toll-like receptors in inflammation, Plenum Press, 2005Book, 2005
• Mansell A, Toynbee J, Gray P, Doyle S, Hilton D, O'Neill LA and Hertzog P, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation , Nature Immunology, 7, (2), 2006, p148 - 155Journal Article, 2006, DOI , URL
• O'Neill LA, How Toll-like receptors signal: what we know and what we don't know, Current Opinion in Immunology, 18, (1), 2006, p3 - 9Journal Article, 2006, DOI , URL
• O'Toole D, Abde;-Latif AM, Long A, Windle HJ, Murphy AM, Bowie A, O'Neill LA, Weir DG, Kelleher D, Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?, Journal of Cellular Biochemistry, 96, (3), 2005, p589 - 588Journal Article, 2005, DOI , URL
• Dunne A and O'Neill L, New insights into the post-translational modification of Toll-like receptor, Journal of Endotoxin Research, 11, (6), 2005, p325 - 332Journal Article, 2005, DOI , URL
• Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495Journal Article, 2006, DOI , TARA - Full Text
• O'Neill LA, Targetting signal transduction pathways as a strategy for anti-inflammatory drugs, Nature Reviews Drug Discovery, 2006Journal Article, 2006
• Kelly VP and O'Neill LA, Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma, Biochemical Society Transactions, 23, (4), 1995, p597S - 597SJournal Article, 1995
• O'Neill LA and Bowie AG, The family of five: TIR domain containing adapters in TLR signalling, Nat Rev Immunol, 7, 2007, p353-364Journal Article, 2007, DOI , URL
• Sheedy F. and O'Neill L.A., The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling, Journal of Leukocyte Biology, 82, (2), 2007, p196-203Journal Article, 2007, DOI , TARA - Full Text
• Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528Journal Article, 2007, DOI , TARA - Full Text
• Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377Journal Article, 2007, DOI , TARA - Full Text
• Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL, Resolution of inflammation: state of the art, definitions and terms, The FASEB Journal, 21, (2), 2006, p325 - 332Journal Article, 2006, DOI , TARA - Full Text
• Wietek,C, Cleaver, CS, Ludbrook, V, Wilde, J, White, J, Bell, DJ, Lee, M, Dickson, M, Ray, KP and O'Neill, LAJ, IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65, The Journal of Biological Chemistry, 281, (46), 2006, p34973 - 34981Journal Article, 2006, DOI , TARA - Full Text
• Doyle, SL and O'Neill LAJ, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol., 72, (9), 2006, p1102 - 1113Journal Article, 2006, DOI , URL
• O'Neill LA, DisSARMing Toll-like receptor signaling, Nat Immunol., 7, (10), 2006, p1023 - 1025Journal Article, 2006, DOI , URL
• Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357Journal Article, 2006, DOI , URL
• Miggin SM and O'Neill LA, New insights into the regulation of TLR signaling, Journal of Leukocyte Biology, 80, (2), 2006, p220 - 226Journal Article, 2006, DOI , TARA - Full Text
• O'Neill LA, Targeting signal transduction as a strategy to treat inflammatory diseases, Nature Rev. Drug Disc, 5, (7), 2006, p549 - 563Journal Article, 2006, DOI , URL
• McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201Journal Article, 2006, DOI , TARA - Full Text
• Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proceedings of the National Academy of Sciences , 103, (16), 2006, p6299 - 6304Journal Article, 2006, DOI , TARA - Full Text
• Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O'Neill LA* and Hertzog P* , Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation, Nature Immunol., 7, (2), 2006, p148 - 155Journal Article, 2006, DOI , URL
• Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, Journal of Biological Chemistry, 280, (25), 2005, p23496 - 23501Journal Article, 2005, DOI
• O'Neill LA, Toll-like receptors: Professor Metchnikov, sit on your hat, Trends in Immunol, 125, (12), 2004, p687 - 693Journal Article, 2004, DOI , URL
• Mansell, A, Brint E, Gould, JA, O'Neill, LA and Hertzog, P, Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4, Journal of Biological Chemistry, 279, (36), 2004, p37227 - 37230Journal Article, 2004, DOI , TARA - Full Text
• Brennan P, O'Neill LA., 2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF kappa B by PDTC., Biochemical Journal, 320, (3), 1997, p975 - 981Journal Article, 1997, URL
• Moynagh PN, Williams DC, O'Neill LA., Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants., Journal of Immunology, 153, (6), 1994, p2681 - 2690Journal Article, 1994, URL
• Cleere R, Long A, Kelleher D, O'Neill LA., Autocrine regulation of the transcription factor NF kappa B by TNF alpha in the human T cell lymphoma line Hut 78., Biochemical Society Transactions, 23, (1), 1995, pS113 - S113Journal Article, 1995
• Maria A. O'Connell, Roisin Cleere , Aideen Long , Luke A. J. O'Neill , Dermot Kelleher , Cellular Proliferation and Activation of NFB Are Induced by Autocrine Production of Tumor Necrosis Factor in the Human T Lymphoma Line HuT 78 , Journal of Biological Chemistry, 270, (13), 1995, p7399 - 7404Journal Article, 1995, URL
• DUNICAN, DJ, GRIFFITHS, R, ONEILL, LAJ, WILLIAMS, DC, DEPOLARIZING LEVELS OF KCI INHIBIT ENDOTHELIN-1-MEDIATED RELEASE OF ARACHIDONIC-ACID IN RAT C6 GLIOMA-CELLS, Biochemical Society Transactions, 23, (1), 1995, pS285 - S285Journal Article, 1995
• McCarthy LM, O'Neill LA., Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS82 - S82Journal Article, 1996
• Brennan P, O'Neill LA., Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals., Biochimica et Biophysica Acta (BBA) -Gene Structure and expression, 1260, (2), 1995, p167 - 175Journal Article, 1995, DOI , URL
• McCarthy LM, O'Neill LAJ, Effects of pertussis toxin and its binding subunit on IL-1 signaling in T-cells, Biochemical Society Transactions, 23, (1), 1995, pS112 - S112Journal Article, 1995
• Dunican DJ, Griffiths R, Williams DC, O'Neill LA., Endothelin-1 increases arachidonic acid release in C6 glioma cells through a potassium-modulated influx of calcium., Journal of Neurochemistry, 67, (2), 1996, p830 - 837Journal Article, 1996
• Mahon TM, O'Neill LA., Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A., Biochemical Society Transactions, 23, (1), 1995, pS111 - S111Journal Article, 1995
• Luke A J O'Neill, How does interleukin-1 activate cells?, Kidney International , 41, 1992, p546 - 549Journal Article, 1992, DOI , URL
• FITZGERALD, K, INDUCTION OF THE ADHESION MOLECULE CD44 BY THE PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1 IN ENDOTHELIAL CELLS, unknown, 1996, 89, ISI Web of Science, 1996, ppF69 - F69Meeting Abstract, 1996
• Fitzgerald K, O'Neill LA., Induction of the adhesion molecule CD44 by the pro-inflammatory cytokine interleukin-1 in endothelial cells., Biochemical Society Transactions, 25, (2), 1997, pS185 - S185Journal Article, 1997
• CUNNINGHAM, A, INHIBITION OF LONG-TERM POTENTIATION BY TUMOR-NECROSIS-FACTOR IN THE RAT DENTATE GYRUS IN-VITRO, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P6Meeting Abstract, 1995
• Brennan P, O'Neill LA., Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide., Biochemical Society Transactions, 24, (1), 1996, pS3 - S3Journal Article, 1996
• Brennan P, O'Neill LA., Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers., Biochemical Pharmacology, 55, (7), 1998, p965 - 973Journal Article, 1998, DOI , URL
• PALSSON, EM, INHIBITION OF P38 AND P42/P44 MAPK BY CLOSTRIDIUM SORDELLII LETHAL TOXIN IN IL-1 STIMULATED T LYMPHOCYTES - A ROLE FOR A RAS SUBFAMILY G PROTEIN IN IL-1 SIGNALLING, unknown, 1998, 9, ISI Web of Science, 1998, pp457 - 457Meeting Abstract, 1998
• O'Neill, LAJ, Interleukin I receptors and signal transduction., Biochemical Society Transactions, 24, (1), 1996, p207 - 211Journal Article, 1996
• O'Neill LA, Matthews JS, Pålsson E, Jeffries C, Brennan P, Cantrell DA., Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase., Biochemical Society Transactions, 25, (4), 1998, pS578 - S578Journal Article, 1998
• Moynagh PN, O'Neill LA, Williams DC., Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells., Biochemical Pharmacology, 46, (5), 1993, p821 - 827Journal Article, 1993, DOI , URL
• Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20Journal Article, 1996, DOI , URL
• Stylianou E, O'Neill LA, Rawlinson L, Edbrooke MR, Woo P, Saklatvala J., Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes., Journla of Biological Chemistry, 267, (22), 1992, p15836 - 15841Journal Article, 1992, URL , TARA - Full Text
• O'Neill, LAJ, Interleukin-1 signal transduction., Ineternational Journal of Clinical & Laboratory Research, 25, (4), 1996Review, 1996
• FITZGERALD, K, INTERLEUKIN-1 UPREGULATES EXPRESSION OF METASTASIS-ASSOCIATED VARIANT V6 IN THE HUMAN ENDOTHELIAL CELL LINE ECV304 BY A MECHANISM INVOLVING THE TRANSCRIPTION FACTOR EGR-1., unknown, 1998, 78, ISI Web of Science, 1998, pp16 - 16Meeting Abstract, 1998
• Mahon TM, O'Neill LA., Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS81 - S81Journal Article, 1996
• FITZGERALD, KA, MAL (MYD88 ADAPTER-LIKE) IS REQUIRED FOR TOLL-LIKE RECEPTOR-4 SIGNAL TRANSDUCTION, unknown, 2001, ISI Web of Science, 2001, pp33 - 33Meeting Abstract, 2001
• O'Neill, LA, Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture., Biochemical Society Transactions, 25, (1), 1997, p295 - 302Journal Article, 1997
• O'Neill LA, Kaltschmidt C., NF-kappa B: a crucial transcription factor for glial and neuronal cell function., Trends in Neurosciences, 20, (6), 1997, p252 - 258Journal Article, 1997, DOI , URL
• Bowie A, O'Neill LA., Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries., Biochemical Pharmacology, 59, (1), 1999, p13 - 23Journal Article, 1999, DOI , URL
• MATTHEWS, JS, P38 ACTIVATION AS A KEY EVENT IN THE INDUCTION OF IL2 BY IL1 IN T LYMPHOCYTES, unknown, 1996, 89, ISI Web of Science, 1996, ppAA398 - AA398Meeting Abstract, 1996
• O'Neill LA, Greene C., Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants., Journal of Leukocyte Biology , 63, (6), 1998, p650 - 657Journal Article, 1998, URL , TARA - Full Text
• Hassan J, O'Neill S, O'Neill LA, Pattison U, Reen DJ., Signalling via CD28 of human naive neonatal T lymphocytes., Clinical and Experimental Immunology, 102, (1), 1995, p192 - 198Journal Article, 1995, URL , TARA - Full Text
• Mahon TM, Matthews JS, O'Neill LA., Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells., Biochemical Journal, 325, (1), 1997, p39 - 45Journal Article, 1997, URL , TARA - Full Text
• Mahon TM, O'Neill LA., Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit., Journal of Biological Chemistry, 270, (48), 1995, p28557 - 28564Journal Article, 1995, DOI , URL , TARA - Full Text
• O'Neill LA, Kelly VP., Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma., Biochemical Society Transactions, 23, (4), 1996, pS597 - S597Journal Article, 1996
• BRINT, B, T1/ST2 SIGNAL TRANSDUCTION: ACTIVATION OF AP-1, JNK, P38 AND P42/P44 MAP KINASE BUT NOT NF-KAPPAB, unknown, 2001, ISI Web of Science, 2001, pp58 - 58Meeting Abstract, 2001
• MATTHEWS, JS, THE EFFECT OF MAPKK INHIBITOR PD98059, THE P38MAPK INHIBITOR SB203580 AND THE SMALL G PROTEIN RAC 1 ON INTERLEUKIN 1 SIGNAL TRANSDUCTION IN T LYMPHOCYTES, unknown, 1996, 119, ISI Web of Science, 1996, ppP12 - P12Meeting Abstract, 1996
• Commins S, O'Neill LA, O'Mara SM., The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., Neuroscience, 102, (2), 2001, p273 - 280Journal Article, 2001, DOI , URL
• Omara, SM, O'Neill LAJ, The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250Meeting Abstract, 2000
• Coogan, A, O'Neill, LAJ, The p38 MAP kinase inhibitor SB203580 antagonizes the inhibitory effect of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro, unknown, 1997, 501P, ISI Web of Science, 1997, ppP86 - P87Meeting Abstract, 1997
• McGowan AJ, Bowie AG, O'Neill LA, Cotter TG., The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult., Experimental Cell Research, 238, (1), 1998, p248 - 256Journal Article, 1998, DOI , URL
• O'Connell MA, Kelleher D, Liskamp RM, Hall N, O'Neill LA, Long A., TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes., Cytokine, 9, (2), 1997, p83 - 92Journal Article, 1997, DOI , URL
• BOLAND, MP, TOPOISOMERASE II IS A TARGET FOR ANTHRACYCLINE-MEDIATED ACTIVATION OF NF KAPPA B, unknown, 1998, 78, ISI Web of Science, 1998, pp9 - 9Meeting Abstract, 1998
• O'Neill, LAJ, Towards an understanding of the signal transduction pathways for interleukin 1., Biochimica et Biophysica Acta (BBA) , 1266, (1), 1995Review, 1995
• O'Neill, L.A., Innate Immunity: Squelching Anti-Viral Signalling with NLRXI, Curr Biol, 18, (7), 2008, pR302-R304Journal Article, 2008, DOI , URL
• O'Neill L.A., Bacteria fight back against Toll-like receptors., Nat Med., 14, (4), 2008, p370-372Journal Article, 2008, DOI , URL
• McCoy CE, Carpenter S, Palsson-McDermott EM, Gearing J, O'Neill, LA, Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like, The Journal of Biological Chemistry, 283, 2008, p14277-14285Journal Article, 2008, DOI , TARA - Full Text
• Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969Journal Article, 2008, DOI , URL
• Sheedy FJ, Marinou I, O'Neill LA, Wilson AG., The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to or severity of rheumatoid arthritis., Ann Rheum Dis., 2008Journal Article, 2008, DOI , URL
• O'Neill LA., TAMpering with toll-like receptor signaling., Cell, 131, (6), 2007, p1039-41Journal Article, 2007, DOI , URL
• Brikos C, O'Neill LA. , Signalling of toll-like receptors., Handb Exp Pharmacol., 183, 2008, p21-50Review, 2008
• Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE., Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance, Journal of Biological Chemistry, 283, (6), 2008, p3109-19Journal Article, 2008, DOI , TARA - Full Text
• Palsson-McDermott EM, O'Neill, LA. , Building an immune system from nine domains., Biochem Soc Trans., 35, (6), 2007, p1437-44Review, 2007, URL
• Palsson-McDermott EM, O'Neill LA. , The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60Review, 2007, DOI , URL
• McCoy CE, O'Neill LA., The role of toll-like receptors in macrophages., Front Biosci., 1, (13), 2008, p62-70Journal Article, 2008, DOI , URL
• Doyle SL, Jefferies CA, Feighery C, O'Neill LA., Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase., Journal of Biological Chemistry, 282, (51), 2007, p36953-36960.Journal Article, 2007, DOI , TARA - Full Text
• McGettrick AF, O'Neill LA., Toll-like receptors: key activatory of leucocytes and regulator of haematopoiesis, Br J Haematol., 139, (2), 2007, p185-93Journal Article, 2007, DOI , URL
• Becker CE, O'Neill LA., Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs., Semin Immunopathol. , 29, (3), 2007, p239-48.Journal Article, 2007, DOI , URL
• Nuñez Miguel R, Wong J, Westolll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant, A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins., PLoS ONE, 2, (8), 2007, pe788.Journal Article, 2007, DOI , URL , TARA - Full Text
• Watters TM, Kenny EF, O'Neill, LA., Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins., Immunol Cell Biol., 85, (6), 2007, p411-419.Journal Article, 2007, DOI , URL
• Wietek C, O'Neill LA., Diversity and regulation in the NF-kappaB system., Trends Biochem Sci., 32, (7), 2007, p311-319.Journal Article, 2007, DOI , URL
• Carpenter S, O'Neill LA., How important are Toll-like receptors for antimicrobial responses?, Cell Microbiology, 9, (8), 2007, p1891-1901.Journal Article, 2007, DOI , URL
• Constantinos Brikos, Robin Wait, Shajna Begum, Luke A. J. O'Neill, and Jeremy Saklatvala,, Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components, Molecular and Cellular Proteomics, 6, 2007, p1551-1559Journal Article, 2007, DOI , TARA - Full Text
• Gubster C, Goodbody R, Ecker A, Brady G, O'Neill LA, Jacobs N, Smith GL., Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus, Journal of General Virology, 88, (6), 2007, p1667-1676Journal Article, 2007, DOI , TARA - Full Text
• Murphy, M and O'Neill, LAJ (eds), What is Life? The next 50 years, Cambridge, UK, Cambridge University Press, 1995Book, 1995
• O'Neill, L.A.J. and Bowie, A.G. (editors) , Interleukin Protocols, New Jersey, USA, Methods in Molecular Medicine Series, Humana Press, 2001, 443ppBook, 2001
• O'Neill, LAJ, Fitzgerald, K, Gearing, AJH and Callard, R, Cytokine Factsbook, 2nd, London, U.K, Academic Press, 2001, 513ppBook, 2001
• O'Neill, LAJ, Barratt, ML and Lewis, GP, Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect, British Journal of Clinical Pharmacology, 23, (1), 1987, p81 - 83Journal Article, 1987, URL , TARA - Full Text
• O'Neill, LAJ, Barratt, ML and Lewis, GP, Induction of cyclooxygenase by interleukin-1 in rheumatoid synovial cells., FEBS Letts , 212, (1), 1987, p35 - 39Journal Article, 1987, DOI , URL
• O'Neill, LAJ and Lewis, GP, Interleukin-1 potentiates bradykinin- and TNF- induced PGE2 release, European Journal of Pharmacology, 166, (2), 1989, p131 - 137Journal Article, 1989, DOI , URL
• O'Neill, LAJ and Lewis, GP, Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced PGE2 release: a novel effect on free arachidonic acid levels in human synovial cells, Biochem Pharmacol , 38, (21), 1989, p3707 - 3711Journal Article, 1989
• O'Neill, LAJ, Bird, TA, Gearing, AJH and Saklatvala, J, Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). , J Biol Chem , 265, (6), 1990, p3146 - 3152Journal Article, 1990, URL
• O'Neill, LAJ, Bird, TA and Saklatvala, J, Interleukin 1 signal transduction, Immunol Today , 11, 1990, p392 - 394Journal Article, 1990, DOI , URL
• Saklatvala, J, Bird, TA, Kaur, P and O'Neill, LAJ , IL1 signal transduction: evidence of activation of G protein and protein kinase, Progress in Clinical Biological Research, 349, 1990, p285 - 295Journal Article, 1990
• O'Neill, LAJ, Ikebe, T, SJ Sarsfield and Saklatvala, J, , The binding sub-unit of pertussis toxin inhibits IL1 induction of IL2 and prostaglandin production, Journal of Immunology, 148, (2), 1992, p474 - 479Journal Article, 1992, URL
• O'Neill, LAJ , Interleukin 1, a central mediator of inflammation, Journal of Biomedical Science, 3, 1992, p7 - 12Journal Article, 1992
• O'Neill, LAJ, Murphy, M and Gallagher, RB , What are we? Where did we come from? Where are we going?, Science , 263, (5144), 1994, p181 - 183Journal Article, 1994, DOI , URL
• The IL1 receptor / Toll-like receptor superfamily in, editor(s)J Oppenheim and M Feldmann , The Cytokine Reference, Academic Press, 2000, pp1565 - 1586, [O'Neill, LAJ and Dower, SJ ]Book Chapter, 2000
• Wietek, C and O'Neill, LAJ , IRAK-4: a new drug target in inflammation, sepsis and autoimmunity, Molecular Interventions, 2, (4), 2002, p212 - 215Journal Article, 2002, URL , TARA - Full Text
• Harte, MT, Haga, I, Maloney, G, Gray, P, Reading, PC, Bartlett, N, Smith, GL, Bowie, AG and O'Neill, LAJ , The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence, Journal of Experimental Medicine, 197, (3), 2003, p343 - 351Journal Article, 2003, DOI , TARA - Full Text
• O'Neill LA , Antisense modulation of TLR-4 expression, Expert Opinion on Therapeutic Patents, 13, (12), 2003, p1887 - 1889Journal Article, 2003, DOI , URL
• Hardy, M, McGettrick, A and O'Neill, LAJ , Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene., Biochemical Journal, 380, (1), 2004, p83 - 93Journal Article, 2004, DOI , TARA - Full Text
• O'Neill LA , Immunity's early warning system, Scientific American , 292, (1), 2005, p38 - 45Journal Article, 2005, URL
• O'Neill, L.A.J, A roll-call of monocytic gene induction, Trends in Immunology, 22, (4), 2001, p182Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, Co-stimulating allergy, Trends in Immunology, 22, (4), 2001, p183Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, An AIDS vaccine in sight? , Trends in Immunology, 22, (5), 2001, p242Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, A role for leptin in autoimmunity? , Trends in Immunology, 22, (7), 2001, p352Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, Gob genes, mucus and asthma. , Trends in Immunology, 22, (7), 2001, p353Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, IL-1 versus TNF in arthritis?. , Trends in Immunology, 22, (7), 2001, p353-354Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, A vaccine for colorectral cancer, Trends in Immunology, 22, (7), 2001, p354Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, Irish say no to Nice but yes to immunology, Trends in Immunology, 22, (8), 2001, p421Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, Vaccine safety concerns, Trends in Immunology, 22, (8), 2001, p420 - 421Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, Crohn's disease gene is given the NOD, Trends in Immunology, 22, (8), 2001, p418 - 419Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, A role for leptin in autoimmunity, Trends in Pharmacological Sciences, 22, (7), 2001, p341Journal Article, 2001, DOI , URL
• O'Neill, L.A.J, A gene for Crohn's disease is given the nod, Trends in Pharmacological Sciences, 22, (8), 2001, p398 - 399Journal Article, 2001, DOI , URL
• Pålsson-McDermott EM, O'Neill LA., The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60Journal Article, 2007, DOI , URL
• Chau TL, Gioia R, Gatot JS, Patrascu F, Carpentier I, Chapelle JP, O'Neill L, Beyaert R, Piette J, Chariot A, Are the IKKs and IKK-related kinases TBK1 and IKK-varepsilon similarly activated?, Trends Biochem Sci, 33, (4), 2008, p171-80Journal Article, 2008, DOI , URL
• O'Neill LA , Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?, Nat Clin Pract Rheumatol., 4, (6), 2008, p319-27Journal Article, 2008, DOI
• O'Neill LA, 'Fine tuning' TLR signaling, Nat Immunol. , 9, (5), 2008, p459-61Journal Article, 2008, DOI , URL
• O'Neill LAJ, Immunology. How frustration leads to inflammation., Science, 320, (5876), 2008, p619-20Journal Article, 2008, DOI , URL
• O'Neill LAJ , When signalling pathways collide: positive and negative regulation of Toll-like receptor signalling, Immunity , 29, (1), 2008, p12 - 20Journal Article, 2008, DOI , URL
• O'Neill LA, The interleukin-1 receptor / Toll-like receptor superfamily: ten years of progress, Immunological Reviews, 226, (1), 2008, p10 - 18Journal Article, 2008, DOI , URL
• Sheedy FJ, O'Neill LA., Adding fuel to fire: microRNAs as a new class of mediators of inflammation., Annals of the Rheumatic Diseases, 67 , (Suppl 3), 2009, piii50 - iii55Journal Article, 2009, DOI , URL
• Kenny EF, O'Neill LA., Signalling adaptors used by Toll-like receptors: an update., Cytokine, 43, (3), 2008, p342 - 349Journal Article, 2008, DOI , URL
• Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586Journal Article, 2009, DOI
• O'Neill LAJ and McCoy C, Toll-like receptor protocols. Methods in Molecular Medicine Series, 517, New Jersey USA , Humana Press, 2009Book, 2009
• Uncovering novel gene function in TLR signalling using siRNA in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Carty, M., Keating, S. & Bowie, A.G. ]Book Chapter, 2009
• Characterisation of viral proteins that inhibit TLR signal transduction in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Stack, J & Bowie, A.G.]Book Chapter, 2009
• Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875Journal Article, 2009, DOI , TARA - Full Text
• K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology, 164, (4), 2000, p2053-2063Journal Article, 2000
• Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537Journal Article, 2009, DOI , TARA - Full Text
• Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28Journal Article, 2010, DOI , URL
• O'Neill LA, Regulation of signaling by non-degradative ubiquitination., The Journal of Biological Chemistry, 284, (13), 2009, p8209Journal Article, 2009, DOI , URL
• Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709Journal Article, 2009, DOI
• O'Neill LA, Bryant CE, Doyle SL, Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer., Pharmacological Reviews, 61, (2), 2009, p177-97Journal Article, 2009, DOI
• Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG., Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock, Proceedings of the National Academy of Science USA, 106, (25), 2009, p10272-10277Journal Article, 2009, DOI
• Carpenter S, O'Neill LA , Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins., Biochemistry Journal, 422, (1), 2009, p1-10Journal Article, 2009, DOI
• O'Neill LA., DNA makes RNA makes innate immunity, Cell, 138, (3), 2009, p428-430Journal Article, 2009, DOI
• Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995Journal Article, 2009, DOI
• McCormack WJ, Parker AE, O'Neill LA., Toll-like receptors and NOD-like receptors in rheumatic diseases., Arthritis Research & Therapy , 11, (5), 2009, p243Journal Article, 2009, DOI
• O'Neill LA, A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis?, Gastroenterology., 137, (6), 2009, p1889-1891Journal Article, 2009, DOI
• O'Neill LA, Boosting the brain's ability to block inflammation via microRNA-132., Immunity, 31, (6), 2009, p854-855Journal Article, 2009, DOI
• Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147Journal Article, 2010, DOI
• Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP., Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. , Circulation., 121, (1), 2010, p80-90Journal Article, 2010, DOI , URL , TARA - Full Text
• McGettrick AF, O'Neill LA, Localisation and trafficking of Toll-like receptors: an important mode of regulation. , Current Opinion in Immunology, 22, (1), 2010, p20-27Journal Article, 2010, DOI
• Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357Journal Article, 2009, DOI
• Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282Journal Article, 2010, DOI
• YanMei Liang, Jeremy Hetzel, Ansu Noronha, Daniel Onguru, Susan Carpenter, Melanie Mott, Sherman Biogornia, Caroline Apovian, Noyan Gokce, Jennifer Coukos, Dennis Kasper, Luke O'Neill, Pauline Mwinzi, Francis Farraye, Marie McDonnell, Lisa Ganley-Leal., Systemic Toll-like receptor ligands modify B cell responses in human chronic inflammatory disease., Journal of Clinical Investigation., 2010, p1-10Journal Article, 2010, DOI
• McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, (27), 2010, p20492-20498Journal Article, 2010, DOI , URL , TARA - Full Text
• Madden SF, Carpenter SB, Jeffery IB, Bjorkbacka H, Fitzgerald KA, O'Neill LA, Higgins DG, Detecting microRNA activity from gene expression data., BMC Bioinformatics, 11, (1), 2010, p257Journal Article, 2010, DOI , URL , TARA - Full Text
• O'Neill, L.A.J., Bowie, A.G., Sensing and Signaling in Antiviral Innate Immunity , Current Biology , 20, (7), 2010, pR328-R333Journal Article, 2010, DOI , TARA - Full Text
• Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904Journal Article, 2010, DOI
• Coll, R.C., O'Neill, L.A.J., New insights into the regulation of signalling by toll-like receptors and nod-like receptors, Journal of Innate Immunity, 2, (5), 2010, p406-421Journal Article, 2010, DOI
• O'Neill, L.A.J, Stopping sepsis by targeting sphingosine kinase 1, Science Translational Medicine, 2, (36), 2010, p36ps29Journal Article, 2010, DOI
• O'Neill, L.A.J., Hennessy, E.J., Parker, A.E, Targeting Toll-like receptors: Emerging therapeutics?, Nature Reviews Drug Discovery, 9, (4), 2010, p293-307Journal Article, 2010, DOI
• Zhang, X., Shephard, F., Kim, H.B., Palmer, I.R., McHarg, S., Fowler, G.J.S., O'Neill, L.A.J., (...), Qwarnstrom, E.E., TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-κB, Journal of Biological Chemistry, 285, (10), 2010, p7222-7232Journal Article, 2010, DOI , URL , TARA - Full Text
• Gillian M. Tannahill, Luke A.J. O'Neill, The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3, FEBS Letter, 585, (11), 2011, p1568-1572Journal Article, 2011, DOI , URL , TARA - Full Text
• Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA., Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6, Journal of Biological Chemistry, 286, (29), 2011, p25531-9Journal Article, 2011, DOI , URL , TARA - Full Text
• Durrani O, Banahan K, Sheedy FJ, McBride L, Ben-Chetrit E, Greiner K, Vaughan RW, Kondeatis E, Hamburger J, Fortune F, Stanford MR, Murray PI, O'Neill LA, Wallace GR, TIRAP Ser180Leu polymorphism is associated with Behcet's disease., Rheumatology , 50, (10), 2011, p1760-5Journal Article, 2011, DOI , URL
• O'Neill LA, Counter-regulation in the IKK family., The Biochemical Journal, 434, (1), 2011, pe1-2Journal Article, 2011, DOI , URL , TARA - Full Text
• Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Muhammad M. Alam and Luke A. O'Neill, MicroRNAs and the resolution phase of inflammation in macrophages, European Journal of Immunology, 41, (9), 2011, p2482-2485Journal Article, 2011, DOI , URL , TARA - Full Text
• Carpenter S, Wochal P, Dunne A, O'Neill LA, Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL)., The Journal of Biological Chemistry, 286, (44), 2011, p38795-38804Journal Article, 2011, DOI , URL , TARA - Full Text
• Nathalie Court, Stéphanie Rose, Marie-Laure Bourigault, Sophie Front, Olivier R. Martin, Jennifer K. Dowling, Elaine F. Kenny, Luke O'Neill, François Erard, Valerie F. J. Quesniaux, Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms, PLoS ONE, 6, (9, e24631), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• O'Neill LA, A critical role for citrate metabolism in LPS signalling., The Biochemical journal, 438, (3 ), 2011, pe5-6Journal Article, 2011, DOI
• Coll RC, O'Neill LA., The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes, PLoS ONE, 6, (12, e29539), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'Neill LAJ, Qwarnstrom EE, Dower SK, Human tribbles, a protein family controlling mitogen-activated protein kinase cascades, Journal of Biological Chemistry, 279, (41), 2004, p42703 - 42708Journal Article, 2004, DOI , TARA - Full Text
• Khan JA, Brint EK, O'Neill LAJ, Tong L, Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL, Journal of Biological Chemistry, 279, (30), 2004, p31664 - 31670Journal Article, 2004, DOI , TARA - Full Text
• Hardy MP, McGettrick AF, O'Neill LAJ, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, Biochemical Journal, 380, (1), 2004, p83 - 93Journal Article, 2004, URL
• Brint EK, Xu DM, Liu HY, Dunne A, McKenzie ANJ, O'Neill LAJ, Liew FY, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, NATURE IMMUNOLOGY, 5, (4), 2004, p373 - 379Journal Article, 2004, DOI , URL
• Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012Journal Article, 2012, DOI , TARA - Full Text
• O'Neill LA, Immunology. Sensing the dark side of DNA., Science (New York, N.Y.), 339, (6121), 2013, p763-764Journal Article, 2013, DOI , TARA - Full Text
• O'Neill LA, Hardie DG, Metabolism of inflammation limited by AMPK and pseudo-starvation., Nature, 493, (7432), 2013, p346-355Journal Article, 2013, DOI , TARA - Full Text
• Connolly DJ, O'Neill LA, McGettrick AF, The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling., The Journal of biological chemistry, 288, (8), 2013, p5616-5623Journal Article, 2013, DOI , TARA - Full Text
• Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45Journal Article, 2013, DOI , TARA - Full Text
• O'Neill LA, "Transflammation": when innate immunity meets induced pluripotency., Cell, 151, (3), 2012, p471-3Journal Article, 2012, DOI
• Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL, Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1ß production., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p3795-9Journal Article, 2012, DOI
• Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928Journal Article, 2013, DOI , TARA - Full Text
• Ward SG, O'Neill LA, Spurs in the hunt for new immunomodulatory drug targets., Current opinion in pharmacology, 12, (4), 2012, p439-443Journal Article, 2012, DOI
• Connolly DJ, O'Neill LA, New developments in Toll-like receptor targeted therapeutics., Current opinion in pharmacology, 12, (4), 2012, p510-518Journal Article, 2012, DOI
• Dowling JK, O'Neill LA, Biochemical regulation of the inflammasome., Critical reviews in biochemistry and molecular biology, 47, (5), 2012, p424-443Journal Article, 2012, DOI
• Foley NH, O'Neill LA, miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes., Journal of leukocyte biology, 92, (3), 2012, p521-527Journal Article, 2012, DOI
• Netea MG, Wijmenga C, O'Neill LA, Genetic variation in Toll-like receptors and disease susceptibility., Nature immunology, 13, (6), 2012, p535-542Journal Article, 2012, DOI
• Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798Journal Article, 2012, DOI
• Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299Journal Article, 2012, DOI , TARA - Full Text
• Wen H, Ting JP, O'Neill LA, A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?, Nature immunology, 13, (4), 2012, p352-357Journal Article, 2012, DOI
• Laben JK, Legal issues related to the right to die: implications for nursing education., Deans Notes, 12, (2), 1990, p1-2Journal Article, 1990
• Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP, Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs., Circulation. Cardiovascular interventions, 5, (2), 2012, p279-287Journal Article, 2012, DOI
• Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation., Nature communications, 3, 2012, p707Journal Article, 2012, DOI
• Ultaigh SN, Saber TP, McCormick J, Connolly M, Dellacasagrande J, Keogh B, McCormack W, Reilly M, O'Neill LA, McGuirk P, Fearon U, Veale DJ, Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures., Arthritis research & therapy, 13, (1), 2011, pR33Journal Article, 2011, DOI , TARA - Full Text
• O'Neill LA, Bowie AG, The powerstroke and camshaft of the RIG-I antiviral RNA detection machine., Cell, 147, (2), 2011, p259-261Journal Article, 2011, DOI
• Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+Journal Article, 2013, DOI , TARA - Full Text
• O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045Journal Article, 2009, DOI
• Haneklaus, M., Gerlic, M., O'Neill, L.A.J., Masters, S.L., miR-223: Infection, inflammation and cancer, Journal of Internal Medicine, 274, (3), 2013, p215-226Journal Article, 2013, DOI , TARA - Full Text
• Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066Journal Article, 2013, DOI , TARA - Full Text
• O'Neill, L.A.J., Golenbock, D., Bowie, A.G., The history of Toll-like receptors-redefining innate immunity, Nature Reviews Immunology, 13, (6), 2013, p453-460Journal Article, 2013, DOI , TARA - Full Text
• Mills, E., O'Neill, L.A.J., Succinate: a metabolic signal in inflammation, Trends in Cell Biology, 2013Journal Article, 2013, DOI , TARA - Full Text
• Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67Journal Article, 2014, DOI , TARA - Full Text
• Palsson-Mcdermott, E.M., O'Neill, L.A.J., The Warburg effect then and now: From cancer to inflammatory diseases, BioEssays, 35, (11), 2013, p965-973Journal Article, 2013, DOI , TARA - Full Text
• Bernard, N.J., O'Neill, L.A, Mal, more than a bridge to MyD88, IUBMB Life , 65, (9), 2013, p777-786Journal Article, 2013, DOI , TARA - Full Text
• Mcgettrick, A.F., O'Neill, L.A.J., NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases, Diabetes, Obesity and Metabolism , 15, (S3), 2013, p19-25Journal Article, 2013, DOI , TARA - Full Text
• Kenny, E.F., Quinn, S.R., Doyle, S.L., Vink, P.M., van Eenennaam, H., O'Neill, L.A.J., Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin, PLoS ONE, 8, (8), 2013, part. no. e74103Journal Article, 2013, DOI , TARA - Full Text
• Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J. , Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104) (Erratum), 2013, - 17600Miscellaneous, 2013, DOI
• McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, (32), 2013, 22893-22898Journal Article, 2013, DOI , TARA - Full Text
• Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA, A long noncoding RNA mediates both activation and repression of immune response genes., Science (New York, N.Y.), 341, (6147), 2013, p789-92Journal Article, 2013, DOI , TARA - Full Text
• Adamik, J., Wang, K.Z.Q., Unlu, S., Su, A.-J.A., Tannahill, G.M., Galson, D.L., O'Neill, L.A., Auron, P.E., Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α, PLoS One, 8, (8), 2013, pe70622Journal Article, 2013, DOI , TARA - Full Text
• Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA., The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10., The Journel of Biological Chemistry, 289, (9), 2014, p4316-4325Journal Article, 2014, DOI , TARA - Full Text
• Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15., J. Biol. Chem., 288, (35), 2013, p25066 - 25075Journal Article, 2013, TARA - Full Text
• Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi & Luke A.J. O'Neill , Circadian Clock Proteins and Immunity, Immunity, Volume 40, (2), 2014, 178-186Journal Article, 2014, DOI , TARA - Full Text
• Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437Journal Article, 2014, DOI , TARA - Full Text
• O'Neill, L.A.J., Glycolytic reprogramming by TLRs in dendritic cells, Nature Immunology, 15, (4), 2014, p314-315Journal Article, 2014, DOI
• d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816-Journal Article, 2014, DOI , TARA - Full Text
• Mockler MB, Conroy MJ, Lysaght J, Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment., Frontiers in oncology, 4, 2014, p107Journal Article, 2014, DOI , TARA - Full Text
• O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, (5), 2013, p610-2Journal Article, 2013, DOI , TARA - Full Text
• Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80Journal Article, 2015, DOI , TARA - Full Text
• Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260Journal Article, 2015, DOI , TARA - Full Text
• Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992Journal Article, 2015, DOI

• Hughes, O'Neill, Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling, Proceedings of the National Academy of Sciences of the United States of America, 2017Journal Article, TARA - Full Text
• A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2SConference Paper
• A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109SConference Paper
• Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993Meetings /Conferences Organised
• O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCDMeetings /Conferences Organised
• O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCDMeetings /Conferences Organised
• Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390SConference Paper
• Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125SConference Paper
• Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S.Conference Paper

CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Inflammasomes. Immunometabolism.

• Title

  Role of metabolism in innate immunity
  Summary
• Title

  . Novel proteins in the TLR and NLR systems
  Summary
• Title

  Role of Nlrp3 in Type 2 diabetes
  Summary
• Title

  Control of TLRs and NLRs by microRNAs
  Summary
  Funding Agency

  SFI
• Title

  Circadian control of innate immunity
  Summary

Immunology,

• Royal Irish Academy Gold Medal for Life Sciences 2012
• Dublin Institute of Molecular Medicine Medal Lecture 2004
• Advisor to the 2009 Nobel Committee for Physiology or Medicine 2009
• Elected Councillor, International Cytokine Society 2003
• European Federation of Immunology Societies Medal 2014
• Shortlisted for the Boyle Medal, Royal Dublin Society 2002
• International Cytokine and Interferon Society Milstein Award 2018
• Appointed Councillor of the International Cytokine Society(and rising to President in 2012) 2008
• Immunology 'Guru', National Institutes of Health 2009
• Charnock Bradley Award Lecture, University of Edinburgh 2004
• Dolph Adams Award, Society for Leukocyte Biology USA 2003
• Visiting Fellow, Christ's College Cambridge 2016
• McGill University Dan Perry Award Lecture 2010
• Fellow of the Royal Society (FRS) 2016
• Nobel Assembly, Karolinska Institute Research Lecture 2018
• Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence 2009
• Young Investigator Award, International Cytokine Society 1997
• Royal Irish Academy Medal for Biochemistry 1996
• Irish Society for Immunology Medal for Immunology 2004
• Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004
• Appointed Chair of the European Research Council Infection and Immunity Panel 2008
• Fellow, Trinity College Dublin 1996
• President, International Cytokine Society 2012
• Austrian Academy of Sciences Landsteiner Award 2019
• Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland 1995
• Elected Member of the Royal Irish Academy 2004
• University of Oxford Jenner Institute Distinguished Lecturer 2010
• Queen's University Belfast Barcroft Medal 2018
• Short-listed for the Boyle Medal, Royal Dublin Society 1999
• Elected member of European Molecular Biology Organisation (EMBO) 2005
• Science Foundation Ireland Researcher of the Year Award 2009

• Member Royal Irish Academy Life Sciences Committee
• Biochemical Society
• International Cytokine Society (Councillor)
• Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
• American Society for Biochemistry and Molecular Biology
• Member of MRC Advisory Board, UK
• Member of the Pre-clinical committee, Irish Medicines Board

• Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
• Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
• Member, Science Foundation Ireland Biotechnology Advisory Board
• Member of Medical Research Council Advisory Board, UK
• Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
• Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
• Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
• Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
• Member of the Pre-clinical committee, Irish Medicines Board
• Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
• Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
• Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
• Member, Arthritis Foundation of Ireland academic advisory committee
• Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
• Member, Royal Irish Academy Life Sciences Committee
• Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
• Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
• Member Avenir Committee INSERM, French National Insitute of Health
• Member Avenir Committee INSERM, French National Insitute of Health
• Section Editor for Journal of Leukocyte Biology
• Section Editor for Journal of Leukocyte Biology
• Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
• Member, Royal Irish Academy Life Sciences Committee
• Member, Arthritis Foundation of Ireland academic advisory committee
• Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
• External examiner for degree programme in Molecular Medicine, University of Wales
• Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
• External examiner for 40 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
• Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
• Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
• Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
• External examiner for degree programme in Molecular Medicine, University of Wales
• Member, Science Foundation Ireland Biotechnology Advisory Board
• Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
• Member of the Pre-clinical committee, Irish Medicines Board
• Member of Medical Research Council Advisory Board, UK
• External examiner for 40 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
• Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA