Dr. Gavin Davey

• Hayes JM, Frostell A, Cosgrave EF, Struwe WB, Potter O, Davey GP, Karlsson R, Anneren C and Rudd PM , Fc gamma receptor glycosylation modulates the binding of IgG Glycoforms - a requirement for stable antibody interactions. , Journal of Proteome Research , (13), 2014, p5471 - 5485Journal Article, 2014
• Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM, Glycosylation and Fc receptors., Current topics in microbiology and immunology, 382, 2014, p165-99Journal Article, 2014, DOI
• McDonald AG, Tipton KF, Davey GP, A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts., PLoS computational biology, 12, (4), 2016, pe1004844Journal Article, 2016, DOI , TARA - Full Text
• Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352Journal Article, 2015, DOI , TARA - Full Text
• Min S, Meehan J, Sullivan LM, Harte NP, Xie Y, Davey GP, Svanborg C, Brodkorb A, Mok KH, Alternatively folded proteins with unexpected beneficial functions., Biochemical Society transactions, 40, (4), 2012, p746-51Journal Article, 2012, DOI , TARA - Full Text
• McDonald AG, Hayes JM, Davey GP, Metabolic flux control in glycosylation., Current opinion in structural biology, 40, 2016, p97-103Journal Article, 2016, DOI
• Hayes J.M, Wormald M.R, Rudd P.M, Davey G.P, Fc gamma receptors: Glycobiology and therapeutic prospects, Journal of Inflammation Research, 9, 2016, p209 - 219Journal Article, 2016, DOI , URL , TARA - Full Text
• Almeida A, Brooks KJ, Sammut I, Keelan J, Davey GP, Clark JB, Bates TE., Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain, Dev Neurosci, 17, (4), 1995, p212 - 218Journal Article, 1995
• Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB., Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo, Neuroreport, 7, (8), 1996, p1397 - 400Journal Article, 1996
• Taurine, taurine analogues, and mitochondrial function and dysfuntion in, Taurine 6, 2006, pp469 - 479, [M Palmi, G Davey, KF Tipton, A Meini]Book Chapter, 2006
• Keith F Tipton, Gavin Davey, Martha Motherway, Monoamine oxidase assays, Current Protocols in Toxicology, 2006, p4.21.1 - 4.21.42Journal Article, 2006
• Djikic, T., Martí, Y., Spyrakis, F., (...), Schloss, P., Yelekci, K., Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities, Journal of Biomolecular Structure and Dynamics, 2018, p1-16Journal Article, 2018, DOI
• Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms, Journal of Biological Chemistry, 290, (47), 2015, p28343 - 28352Journal Article, 2015, URL
• McDonald A.G., Tipton K.F. and Davey G.P., A mechanism for bistability in glycosylation, PLOS Computational Biology, 14, (8), 2018, pe1006348-Journal Article, 2018, DOI , TARA - Full Text
• Sinevici N, Mittermayer S, Davey GP, Bones J, O'Sullivan J, Salivary N-glycosyalation as a biomarker of Oral Cancer: A pilot study., Glycobiology, 2019Journal Article, 2019, DOI
• Darren O'Hara, Gavin M. Davis, Natalie A. Adlesic, Jerrard M. Hayes and Gavin P. Davey, Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration, frontiers in Molecular Neuroscience, 2019Journal Article, 2019, DOI , TARA - Full Text
• Vare lija D, Tipton KF, Davey GP, McDonald AG, 6-Hydroxydopamine: a far from simple neurotoxin., J Neural Transm, 2020Journal Article, 2020, DOI
• Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE , Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages, Nature Communications, 12, (1), 2021, p1460-Journal Article, 2021, DOI
• Kilbride, SM, Telford, JE and Davey, GP, Complex I controls mitochondrial and plasma membrane potentials in nerve terminals, Neurochemical Research, 2020Journal Article, 2020, DOI
• Abascal JF, Chiaino E, Frosini M, Davey GP, Valoti , β-Naphthoflavone and Ethanol Reverse Mitochondrial Dysfunction in A Parkinsonian Model of Neurodegeneration, International Journal of Molecular Sciences , 2020Journal Article, 2020, DOI
• Martignoni M; Benedetti M; Davey GP; Tipton KF; McDonald A, Degradation of thymic humoral factor 2 in human, rat and mouse blood: an experimental and theoretical study, BBA - Proteins and Proteomics, 2020Journal Article, 2020, DOI
• McDonald AG and Davey GP , Simulating the enzymes of ganglioside biosynthesis with Glycologue, Beilstein Journal of Organic Chemistry , 2021Journal Article, 2021, DOI
• Smith J, Millán-Martín S, Mittermayr S, Hilborne V, Davey G, Polom K, Roviello F, Bones J., 2-Dimensional ultra-high performance liquid chromatography and DMT-MM derivatization paired with tandem mass spectrometry for comprehensive serum N-glycome characterization, Analytica Chimica Acta, 1179, (338840), 2021Journal Article, 2021, DOI
• O'Farrell LK, Fraser AD, Davey GP, Monitoring the Sialome on Human Immune Cells , Methods Mol Biol, 2370, 2021, p323 - 329Journal Article, 2021, DOI
• Hayes JM, O'Hara DM, Davey GP, Metabolic Labeling of Primary Neurons Using Carbohydrate Click Chemistry, Methods Mol Biol, 2021, p315 - 322Journal Article, 2021, DOI
• McDonald AG, Davey GP, O-Glycologue: A Formal-Language-Based Generator of O-Glycosylation Networks, Methods Mol Biol., 2370, 2021, p223 - 236Journal Article, 2021, DOI
• McDonald AG, Mariethoz J, Davey GP, Lisacek F., In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis., Scientific Reports, 27, (12(1)), 2022, p10846-Journal Article, 2022, DOI , TARA - Full Text
• Benevenuto SGM, Domenico MD, Yariwake VY, Dias CT, Mendes-da-Silva C, Alves NO, Caumo SEDS, Vasconcellos P, Morais DR, Cardoso MS, Ianicelli J, Waked D, Davey GP, Boylan F, Costa JL, Veras MM., Prenatal exposure to Cannabis smoke induces early and lasting damage to the brain., Neurochemistry International, 160, 2022Journal Article, 2022
• Palmi M., Youmbi G., Sgaragli G.P., Meini A., Benocci A., Fusi F., Frosini M., Della Corte L., Davey G. P. and Tipton K.F., Advances in Experimental Medicine and Biology, 483, 2000, p87 - 96Journal Article, 2000
• Shanahan KA, Davis GM, Doran CG, Sugisawa R, Davey GP, Bowie AG., SARM1 regulates NAD⁺-linked metabolism and select immune genes in macrophages., The Journal of Biological Chemistry, 300, (2), 2024, p105620Journal Article, 2024, DOI
• Ryoichi Sugisawa, Katharine A. Shanahan, Gavin M. Davis, Gavin P. Davey, Andrew Bowie, SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms, iScience, 27, (6), 2024, p109940Journal Article, 2024, DOI
• Alice Pifferi, Elda Chiaino, Jesus Fernandez-Abascal, Aoife C. Bannon, Gavin P. Davey, Maria Frosini, and Massimo Valoti, Exploring the Regulation of Cytochrome P450 in SH-SY5Y Cells: Implications for the Onset of Neurodegenerative Diseases, Int. J. Mol. Sci, 25, 2024, p7439.-Journal Article, 2024, DOI
• Alsharif B, Biasiotti M, Bader A, Kukula-Koch W, Davey GP, Boylan F., Acetylcholinesterase and monoamine oxidase inhibitory activities of Pistacia falcata Becc. ex Martelli extract., Natural product research, 2025, p1-6Journal Article, 2025
• Slater AS, Hickey RM, Davey GP., Interactions of human milk oligosaccharides with the immune system., Frontiers in immunology, 15, 2024, p1523829Journal Article, 2024
• Farmer MK, Tipton KF and Davey GP, The effects of two salsolinol derivatives on mitochondrial respiration and the likely nature of any endogenous parkinsonism-inducing toxin. In Monoamine Oxidase inhibitors and their role in neurotransmission, In Monoamine Oxidase inhibitors and their role in neurotransmission, 2004, p42 - 55Journal Article, 2004
• O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF, Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do, Neurotoxicology, 25, 2004, p303 - 315Journal Article, 2004
• Tipton KF, Boyce S, O'Sullivan J., Davey G.P. and Healy J., Monoamine Oxidases: Certainties and Uncertanties, Current Med. Chemistry , 11, 2004, p1965 - 1982Journal Article, 2004
• Tipton KF, O'Sullivan MI, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochem Soc Trans, 31, 2003, p711 - 715Journal Article, 2003
• Davey G.P., Peuchen S. and Clark J.B., Energy thresholds in brain mitochondria: potential involvement in neurodegeneration, Journal of Biological Chemistry , (273), 1998, p12753 - 12757Journal Article, 1998
• Davey G.P., Canevari L and Clark J.B. , Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions, Journal of Neurochemistry , (69), 1997, p2564 - 2570Journal Article, 1997
• Davey G.P. and Clark J.B, Control of oxidative phosphorylation in non-synaptic rat brain mitochondria. , Journal of Neurochemistry , (66), 1996, p1617 - 1624Journal Article, 1996
• Davey G.P. and Tipton K.F, Chronic ethanol consumption and mitochondrial sensitivity to 1-methyl-4-phenylpyridinium ion (MPP+) inhibition , Biogenic Amine, (12), 1996, p103 - 115Journal Article, 1996
• Davey G.P., Tipton K.F. and Murphy M.P. , Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode, Biochemical Journal , (288), 1992, p439 - 443Journal Article, 1992
• Davey G.P., Tipton K.F. and Murphy M.P. , Use of an electrode selective for 1-methyl-4-phenylpyridinium (MPP+) to measure its uptake and accumulation by mitochondria , Journal of Neural Transmission Suppl, (40), 1992, p47 - 45Journal Article, 1992
• Davey G.P. and Tipton K.F. , Mitochondria, Cell Death and DNA Damage, Radiation Research , (2), 2000, p390 - 394Journal Article, 2000
• Tipton K.F., Davey G.P. and Motherway M., Monoamine oxidase assays, Current Protocols in Pharmacology , (2), 1999, p3.61 - 3.6.42Journal Article, 1999
• O'Sullivan J, O'Sullivan M, Tipton KF, Unzeta M, Del Mar Hernandez M, Davey GP, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, Biochim Biophys Acta., 1647, (1-2), 2003, p367 - 371Journal Article, 2003
• J O'Sullivan, G Davey, M O'Sullivan, KF Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, J Neural Transm, 2007Journal Article, 2007
• Nomenclature and Potential Functions of Copper Amine Oxidases in, editor(s)Giovanni Floris and Bruno Mondovi , Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology, CRC Press, 2009, [S. Boyce, K. F. Tipton, M. I. O'Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O'Sullivan]Book Chapter, 2009
• Kilbride SM, Telford, JE, Tipton, KF and Davey GP, Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from synaptosomes. , Journal of Neurochemistry, 106, 2008, p826 - 834Journal Article, 2008, TARA - Full Text
• Upadhyay R and Davey GP , Complex I and energy thresholds in the brain, Biochim Biophys Acta Bioenergetics, 1777, 2008, p777 - 782Journal Article, 2008, TARA - Full Text
• Kilbride SM, Telford JE, Davey GP, Age-related changes in H2O2 production and bioenergetics in rat brain synaptosomes, Biochim Biophys Acta Bioenergetics, 1777, 2008, p783 - 788Journal Article, 2008, TARA - Full Text
• McDonald A, Tipton K, O'Sullivan J, Olivieri A, Davey GP, Coonan AM, Fu W, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, 2007, p783 - 786Journal Article, 2007
• O'Sullivan J., Hernandez M., Unzeta M., Tipton K.F. and Davey G.P, Inhibition of semicarbazide sensitive sensitive amine oxidase and adhesion function. , Journal of Neural Transmission, 75, 2006, p105 - 112Journal Article, 2006
• O'Sullivan J., O'Sullivan M.I., Tipton K.F. and Davey G.P. , Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, 71, 2006, p105 - 112Journal Article, 2006
• Telford, JE, Kilbride SM and Davey GP, Complex I is rate limiting for oxygen consumption in the nerve terminal. , Journal Biological Chemistry, 284, 2009, p9109 - 9114Journal Article, 2009, TARA - Full Text
• Simon J.R. Heales, Adrian Menzes, Gavin P. Davey, Depletion of glutathione does not affect electron transport chain complex activities in brain mitochondria: Implications for Parkinsons's disease and postmortem studies, Free Radical Biology and Medicine, 50, (7), 2011, p899-902Journal Article, 2011, DOI , URL , TARA - Full Text
• McDonald, A.G., Tipton, K.F., Stroop, C.J., Davey G.P., GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources., BMC Research Notes, 18, (3), 2010, p1-7Journal Article, 2010, DOI , URL , TARA - Full Text
• Seán M Kilbride, Sonia A Gluchowska, Jayne E Telford, Catherine O'Sullivan and Gavin P Davey, High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal, Molecular Neurodegeneration , 6, (53), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Burleigh SC, van de Laar T, Stroop CJ, van Grunsven WM, O'Donoghue N, Rudd PM, Davey GP, Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells., BMC biotechnology, 11, 2011, p95Journal Article, 2011, DOI , TARA - Full Text
• Tipton KF, Davey GP, McDonald AG, Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead., International review of neurobiology, 100, 2011, p43-64Journal Article, 2011, DOI
• Davey, G.P., Bolaños, J.P., Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: Impact on Parkinson's disease, Journal of Neurochemistry, 125, (3), 2013, p332-333Journal Article, 2013, DOI , TARA - Full Text
• Artemenko, N.V., McDonald, A.G., Davey, G.P., Rudd, P.M., Databases and tools in glycobiology, Methods in Molecular Biology, 899, 2012, p325-350Journal Article, 2012, DOI
• Telford, J.E., Kilbride, S.M., Davey, G.P., Decylubiquinone increases mitochondrial function in synaptosomes, Journal of Biological Chemistry, 285, (12), 2010, p8639-8645Journal Article, 2010, DOI , TARA - Full Text
• McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026Journal Article, 2014, DOI , TARA - Full Text

• Reprogramming human dermal fibroblasts for the generation of pluripotent stem cells. in, editor(s)Freshney, R.I. , Culture of Animal Cells, a Manual of Basic Technique and Specialized Applications, John Wiley & Sons , 2010, [Sullivan S, Davey GP ]Book Chapter
• McDonald AG and Davey GP, 'On/Off Switching During The Synthesis Of Complex Sugars', Science Trends, 2018, -Digital research resource production, DOI , URL
• McDonald AG, Tipton KF and Davey GP, Mathematical modelling of metabolism., The Biochemist, 2009Journal Article

I am an enzymologist and my main research interests are in the areas of enzymology, metabolism, metabolic flux, glycosylation, computational & systems biology. My group researches the molecular and cellular mechanisms that underlie neurodegeneration in the brain, in particular, the role that energy metabolism and bioenergetics play in controlling neuronal function and dysfunction. I am internationally recognised as an expert in bioenergetics and metabolism and more recently in the rapidly expanding area of glycosylation research and glycobiology. A major goal is to understand how abnormal mitochondrial dynamics control cell loss in Parkinson's disease and other common brain disorders. My group also has interests in how mitochondria control immune cell metabolism and we have made some recent exciting high-impact discoveries in this area. I also have made substantial impact in drug development and application of our technologies to the development of next-generation biotherapeutics, including bio- and glyco-engineering of recombinant proteins and therapeutic antibodies. I have established myself among my peers as a researcher with a wide and deep understanding of mitochondria and metabolism by: 1. Discovering how mitochondrial dysfunction in neurons and the ageing brain controls neurodegeneration. I was the first to show that the mitochondrial complex I enzyme system is a major control point for controlling energy thresholds in brain nerve terminals. Through a series of high impact discoveries I am now recognised as an international leader in brain mitochondria research. 2. Showing that the use of flux control analysis and mathematical models of cellular metabolic networks reveal key metabolic control point in neurons, blood brain barrier epithelial cells and recently in immune cells. My advances in computational modelling of N- and O-linked glycosylation networks in cancer cells, immune cells and neurons has led to significant impact in the field of glycobiology and new collaborations with pharmaceutical companies. 3. Discovering how regulating glycosyltransferase enzyme activities can control the glycosylation status of recombinant biotherapeutics in CHO cell production systems. These discoveries have shown the field how to control glycan antennarity on proteins and also led to identification of optimal glycosylation routes for synthesis of human milk oligosaccharides. 4. Recently discovering how electron transport chain activities regulate energy production in immune cells and how this can control pro and anti-inflammatory effects. My expertise in mitochondrial biology has also been used to identify how the immunomodulatory protein SARM1 regulates mitochondrial function and subsequently macrophage cell activation.

• Title

  Mitochondrial fusion dynamics in cancer cells and neurons
  Summary

  A PhD research project focussing on confocal imaging of mitochondrial dynamics in cancer cells and neurons
  Funding Agency

  Irish Research Council
  Date From

  2007
  Date To

  2010
• Title

  Advanced Biopharmaceutical Technologies
  Summary

  Effect of extractables & leachables on CHO cell metabolism during single use bioprocessing.
  Funding Agency

  Science Foundation Ireland
  Date From

  2014
  Date To

  2017
• Title

  Glycoengineering Fc/FcγR interactions
  Summary

  Investigation of cell surface glycosylation and glycan interactions that influence immune responses.
  Funding Agency

  Saudi Education Ministry
  Date From

  2016
  Date To

  2020
• Title

  Understanding glycosylation systems in the brain
  Summary

  An investigation of the dopamine cell surface glycome and regulation of bioenergetics in the context of Parkinson's disease
  Funding Agency

  Parkinson's Association of Ireland
  Date From

  2010
  Date To

  2011
• Title

  Japan - Ireland International Strategic Cooperation Award
  Summary

  SFI funded student/academic exchange program with Japanese research institutions.
  Funding Agency

  Science Foundation Ireland
  Date From

  2014
  Date To

  2016
• Title

  Characterisation of Mitochondrial Proteins in Brain
  Summary

  Establishment of mitochondrial proteomics centre in the School of Biochemistry and Immunology.
  Funding Agency

  European Union
  Date From

  2006
  Date To

  2010
• Title

  Training in neurodegeneration, therapeutics intervention and neurorepair
  Summary

  Research training of 12 PhD students
  Funding Agency

  EU Marie Curie
  Date From

  2013
  Date To

  2017
• Title

  MITOTOX - Mitochondria and Toxicology
  Summary

  In vitro toxicology testing
  Funding Agency

  Enterprise Ireland
  Date From

  2001
  Date To

  2003
• Title

  What is the role for ACAD9 as a neurotherapeutic?
  Summary

  A PhD project investigation the role of ACAD9 on nerve terminal mitochondria function in the context of neurodegeneration.
  Funding Agency

  Irish Research Council
  Date From

  2013
  Date To

  2017
• Title

  Health Research Board Equipment Grant
  Summary
  Funding Agency

  Health Research Board
  Date From

  2000
• Title

  Computational Analysis of the Nerve Terminal
  Summary

  Systems Biology analysis of the nerve terminal in collaboration with Keith Tipton
  Funding Agency

  Science Foundation Ireland
  Date From

  2002
  Date To

  2006
• Title

  Glycan profiling in rheumatoid arthritis patients and biomarker development for MTX and anti-TNF non-responders
  Summary

  2 PhD research projects investigating the metabolomics, bioenergetics and glycosylation status in PBMCs from RA patients.
  Funding Agency

  Croom Arthritis Research Charity
  Date From

  2012
  Date To

  2016

Bioinformatics and computational biology, Agriculture, land and farm management, Biochemistry and cell biology, Neurosciences, Pharmacology and pharmaceutical sciences, Cancer,

• Science Foundation Award Best Academia-Industry Collaboration Prize 2017
• European Union Marie Curie Return Grant 1997
• Irish Pharma Awards - Best Industry-Academia Project 2016
• European Union Human Capital and Mobility Fellowship 1994-1996
• International Conference of Radiation Research conference lecture 1999

• Neuroscience Ireland present
• The Biochemical Society present
• The American Society for Neurochemistry present
• The International Society for Neurochemistry present

• Member of University Council, Trinity College Dublin 2012-2014
• Editor EBEC 2008 BBA Bioenergetics 2008
• Scientific Advisory Board NIBRT 2013