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Dr. Emma Creagh

Dr. Emma Creagh

Associate Professor, Biochemistry

3531896 2539http://www.tcd.ie/Biochemistry/research/e_creagh.php

Publications and Further Research Outputs

  • Creagh E.M., Caspase crosstalk: integration of apoptotic and innate immune signalling pathways., Trends in Immunology, 35, (12), 2014, p631 - 640Journal Article, 2014, DOI
  • Creagh, E.M., A protective role for caspase-11 during acute experimental murine colitis, Faculty of Medicine and Health Sciences Research Seminar Series, Ghent University, Belgium , 16th December, 2014Conference Paper, 2014
  • Creagh, E.M., Kay, E.W., Flood, B., Oficjalska, K., Doherty, G. and Ryan, E., 'Method And Kit For Identification Of Inflamed And Malignant Intestinal Tissue', Trinity Technical Transfer Office, EP14182681.8 , 2020, Trinity CollegePatent, 2020
  • Oficjalska, K., Creagh, E.M., A Protective Role for Caspase-11 during Acute Experimental Colitis, British Society of Immunology Annual Meeting, Brighton, UK, 2-4th December 2014, 2014Poster, 2014
  • Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer , Irish Society of Gastroenterology Winter Proceedings, Dublin, Ireland, 21, 22nd November, 2014Poster, 2014
  • Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50Journal Article, 2015, DOI , TARA - Full Text
  • Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer, Living with Cancer in the 21st Century, Trinity College Dublin, September 2014, 2014Poster, 2014
  • Creagh, E.M., The role of inflammatory caspases during intestinal immunity, Biochemistry lecture series, Maynooth University, Ireland, 11 February, 2014Conference Paper, 2014, TARA - Full Text
  • Creagh, E.M., Inflammatory caspases during IBD, Broad Medical Research Program 'Advances in Understanding IBD', Los Angeles, USA, 22, 23 February 2012, edited by Prof. Daniel Hollander , 2012Oral Presentation, 2012
  • James Fogarty, Innovations in Irish Research, Medical Independent, March, 2013Report, 2013, URL
  • Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60Journal Article, 2015, DOI , TARA - Full Text
  • Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2Journal Article, 2016, DOI , URL , TARA - Full Text
  • Flood B, Oficjalska K, Fay J, O'Grady A, Ryan EJ, Doherty GA, Kay E and Creagh EM. , Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients. , Gasteroenterology, Digestive Diseases Week (DDW), San Diego, CA, 19-24 May 2016, 150, (4), American Gastroenterology Association (AGA), 2016, ppS616-S617Conference Paper, 2016, DOI , TARA - Full Text
  • Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11Journal Article, 2003
  • Ryan, EJ and Creagh, EM, Emerging Methods in Colorectal Cancer Screening, British Journal of Surgery, 105, (2), 2018, p16 - 18Journal Article, 2018, DOI
  • Creagh, E.M., Oesophageal Cancer & Inflammation, Cologne University Research Hospital Seminar Series, Cologne University Research Hospital, Germany, 2nd June, 2017, Dr. H. Fuchs & Prof. J. Beers, CologneInvited Talk, 2017
  • Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia , 'Innovation in Diagnosis & Treatment of Colorectal Neoplasia', Centre for Colorectal Disease, St. Vincent's Hospital, 9th September, 2016, Prof. K SheahanInvited Talk, 2016
  • Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia, Irish Society of Gastroenterology, Summer Proceedings, Irish Society of Gastroenterology, Summer Meeting, Galway, Ireland., June 2016, edited by Michael Dineen, ISG , 2016Oral Presentation, 2016
  • Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674Journal Article, 2019, DOI , TARA - Full Text
  • Kenealy, S. & Creagh, E.M., Novel NLRP6 mutation identified in a patient with an unexplained autoinflammatory disporder, Toll 2018 - Editing Innate Immunity., Porto, Portugal., 6-9 June 2018, 2018Poster, 2018
  • Flis, E and Creagh, E.M., STAT1-mediated tumour suppression is regulated by caspase-11 in a murine model of colitis-associated carcinogenesis., Toll 2018 - Editing Innate Immunity., Porto, Portugal., 2018Poster, 2018
  • Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019, p2389 - 2393Journal Article, 2019, DOI , TARA - Full Text
  • Kufer, T.A., Creagh, E.M. & Bryant C., Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense, Trends in Immunology, 11, (10), 2019Journal Article, 2019, DOI , TARA - Full Text
  • Z. Zas³ona , E. Flis, M.M. Wilk, R.G. Carroll, E.M. Palsson-McDermott, M.M. Hughes, C. Diskin, K. Banahan, D.G. Ryan, A. Hooftman, A. Misiak, J. Kearney, G. Lochnit, W. Bertrams, T. Greulich, B. Schmeck, O.J. McElvaney, K.H.G. Mills, E.C. Lavelle, M. Wygrecka, E.M. Creagh & L.A.J. O'Neill , Caspase-11 promotes allergic airway inflammation, Nature Communications, 2020Journal Article, 2020, URL , TARA - Full Text
  • Creagh, E.M., Inflammatory caspases during colorectal cancer, Cancer Biology & Immunology World Congress, Milan, Italy, March 11-13th 2019, 2019Conference Paper, 2019, URL
  • Flis E. & Creagh E.M., HMGB1- mediates inflammatory TLR2 pathways during oesophageal adenocarcinoma, IACR 56th Annual Conference, Galway, Ireland, 26-28 February 2020, 2020Conference Paper, 2020
  • Nulty C. & Creagh E.M., The Influence of Hormone Receptor Status on the Expression of Inflammatory Caspases in Tumour Microenvironment, IACR 56th Annual Conference, Galway, Ireland, 26-28 February 2020, 2020Conference Paper, 2020
  • G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, A. B. Heeran, E. Flis, N. E. Clarke, J. A. Watson, J. Strangmann, B. Flood, H. O'Neill, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Characterizing caspase-1 involvement during esophageal disease progression. , Cancer Immunology Immunotherapy, 69, (12), 2020, p2635 - 2649Journal Article, 2020, DOI , TARA - Full Text
  • Evaluating host responses to Helicobacter pylori using ELISA and Western Blot. in, Methods in Molecular Biology, Springer, 2021, pp175-190 , [C. Nulty, G. Barber, E. Flis, E.M. Creagh. ]Book Chapter, 2021, DOI
  • G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Identifying a role for caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma., IACR 55th Annual Conference, Belfast, Northern Ireland, February 2019, 2019Conference Paper, 2019
  • G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., Caspase-1 involvement during Barrett's and OAC progression., Oesophageal Cancer Symposium, Cancer Research UK (CRUK), London, UK, April, 2019, 2019Conference Paper, 2019
  • G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., ''Involvement of caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma, 11th International Cancer Conference, TCD, TTMI, Dublin, Ireland, September 2019, 2019Conference Paper, 2019
  • Zaslona Z, Flis E, Nulty C, Kearney J, Fitzgerald R, Douglas AR, McNamara D, Smith S, O'Neill LAJ, Creagh EM., Caspase-4: A Therapeutic Target for Peptic Ulcer Disease, Immunohorizons, 4, (10), 2021, p627 - 633Journal Article, 2021, DOI
  • Agnew, A., Nulty, C., Creagh, E.M., Regulation, Activation and Function of Caspase-11 during Health and Disease., International Journal of Molecular Science, 22, (4), 2021, p1506-Journal Article, 2021, DOI
  • E. Flis, G. Barber, C. Nulty, B. Keogh, P. McGuirk, A. Anand, J. O'Sullivan, M. Quante, E.M. Creagh. , Identification of TLR2 signalling mechanisms which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression, Cancers (Basel) , 13, (9), 2021, p2065 - 2081Journal Article, 2021, DOI , URL
  • Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357Journal Article, 2006, DOI , URL
  • Adrain C, Creagh EM, Martin SJ, Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2, THE EMBO JOURNAL, 20, 2001, p6627 - 6636Journal Article, 2001, DOI , URL , TARA - Full Text
  • Creagh EM, Martin SJ, Caspases: cellular demolition experts., BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p696 - 702Journal Article, 2001
  • Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875Journal Article, 2009, DOI , TARA - Full Text
  • Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537Journal Article, 2009, DOI , TARA - Full Text
  • Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28Journal Article, 2010, DOI , URL
  • Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ, Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival., PloS one, 4, (3), 2009, pe5055Journal Article, 2009, DOI , URL , TARA - Full Text
  • Harris, J..Hartman, M., Roche, C., Zeng, S.G., O'Shea, A., Sharp, F.A., Lambe, E.M., Creagh, E.M., Golenbock, D.T., Tschopp, J., Kornfeld, H., Fitzgerald, K.A. and Lavelle, E.C , Autophagy controls IL-1ß secretion by targeting pro-IL-1ß for degradation, The Journal of Biological Chemistry, 286, 2011, p9587 - 9597Journal Article, 2011, DOI , URL , TARA - Full Text
  • Gorman AM, Heavey B, Creagh E, Cotter TG, Samali A, Antioxidant-mediated inhibition of the heat shock response leads to apoptosis., FEBS letters, 445, (1), 1999, p98-102Journal Article, 1999, DOI , URL
  • Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21Journal Article, 2003
  • Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, (47), 2001, p44069-77Journal Article, 2001, DOI , TARA - Full Text
  • Creagh E.M., Sheehan D. and Cotter T.G. , Heat shock proteins - modulators of apoptosis in tumour cells, Leukemia , 14, 2000, p1161-1173Review Article, 2000
  • Creagh EM, Carmody RJ, Cotter TG, Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells., Experimental cell research, 257, (1), 2000, p58-66Journal Article, 2000
  • Devitt GP, Creagh EM, Cotter TG, The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization., Biochemical and biophysical research communications, 264, (3), 1999, p622-9Journal Article, 1999
  • E M CREAGH and T G COTTER, Selective protection by hsp 70 against cytotoxic drug - but not Fas-induced T-cell apoptosis, Immunology, 97, (1), 1999, p36-44Journal Article, 1999, DOI , URL
  • Murphy BM, Creagh EM, Martin SJ, Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36916 - 36922Journal Article, 2004, DOI , URL , TARA - Full Text
  • Adrain C, Creagh EM, Cullen SP, Martin SJ, Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36923 - 36930Journal Article, 2004, DOI , URL , TARA - Full Text
  • Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ, Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (26), 2004, p26906 - 26914Journal Article, 2004, DOI , URL , TARA - Full Text
  • Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ, Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes, EMBO JOURNAL, 23, (10), 2004, p2134 - 2145Journal Article, 2004, DOI , URL
  • Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11Journal Article, 2003
  • Oficjalska, K., Laukens, D. and Creagh, E.M., Investigation of the role of caspases in a DSS-colitis model of IBD, Irish Society of Gastroenterology Winter Meeting, Dublin, Ireland, 23rd-24th Nov. 2012, 2012Oral Presentation, 2012
  • Ofijalska, K. and Creagh, E.M., Role of caspase-11 in a DSS-colitis model of IBD, The innate immune response in the pathogenesis of infectious disease, Minas Gerais, Brazil, 10-15 May 2013, 2013Poster, 2013
  • Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260Journal Article, 2015, DOI , TARA - Full Text
  • Flis, E and Creagh, E.M., Role of TLR2 in Oesophageal Adenocarcinoma Progression, Training in Cancer Mechanisms & Therapeutics Meeting, Queens University, Belfast, 16th April 2018, 2018Oral Presentation
  • Creagh, E.M., Contribution of Inflammatory caspases to IBD & CRC, INITIative Network meeting, Dublin, Ireland, 23rd November 2018, 2018Invited Talk
  • Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin]Book Chapter
  • Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin]Book Chapter

Recognition

  • Wellcome Trust Career Development Fellowship 2006-2011
  • Broad Medical Research Program Fellowship 2010-2012
  • Voted 'Favorite Woman in Science' 2017, 2018 and 2019 by TCD General Science Students 2017-2019
  • TCD Pathfinder Award 2015
  • Winner - Oral presentation - Irish Society of Gastroenterology Meeting 2016
  • Senior Council Member - Irish Association for Cancer Research (IACR). 2020
  • Irish Epithelial Physiology Group Present
  • Irish Association for Cancer Research (Senior Council Member, 2020-2024) Present
  • American Society for Immunology Present
  • Irish Society of Gastroenterology Present
  • International Society for Mucosal Immunology Present
  • Irish Society of Immunology Present