Dr. Mary Canavan

• Basdeo, S.A., Moran, B., Cluxton, D., (...), Fearon, U., Fletcher, J.M., Polyfunctional, pathogenic CD161⁺ Th17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity, Journal of Immunology, 195, (2), 2015, p528-540Journal Article, 2015, DOI
• Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200Journal Article, 2016, DOI
• Fearon U, Canavan M, Biniecka M, Veale DJ, Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis., 2016Journal Article, 2016
• McGarry T 1 , Biniecka M 1 , Gao W 1 , Cluxton D 2 , Canavan M 1 , Wade S 3 , Wade S 1 , Gallagher L 1 , Orr C 1 , Veale DJ 1 , Fearon U , Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis, Science Reports, 7, (22), 2017, p43165-Journal Article, 2017
• Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S., CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression., Journal of immunology (Baltimore, Md. : 1950), 198, (11), 2017, p4490-4501Journal Article, 2017, DOI
• Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells, Journal of Immunology, 2017Journal Article, 2017, DOI
• Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale, Fearon U, Nagpal S, Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression., PloS one, 2018Journal Article, 2018
• O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M, The pathogenic role of dendritic cells in non-infectious anterior uveitis., Experimental eye research, 2018, p121 - 128Journal Article, 2018, DOI
• Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U, Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B., J Autoimmunity, S0896-84, (S0896-84), 2018Journal Article, 2018
• Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U, Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis., JCI Insight, 3, (23), 2018, p95228-Journal Article, 2018, DOI , TARA - Full Text
• Wade SM, Canavan M, McGarry T, Low C, Wade SC, Mullan RH, Veale DJ, Fearon U, Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis., (Jan 10th), 2019Journal Article, 2019
• Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U., Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis., EBioMedicine. , Sep;47:, 2019, p402 - 413Journal Article, 2019
• Canavan M, Marzaioli V, McGarry T, Bhargava V, Nagpal S, Veale DJ, Fearon U., Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells., Clin Exp Immunol, Nov;202(2):226-238., 2020Journal Article, 2020
• Marzaioli V, Canavan M, Floudas A, Wade SC, Low C, Veale DJ, Fearon U., Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation., Front Immunol, Jul 7;11:1406., 2020Journal Article, 2020
• Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33-Journal Article, 2021
• Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021Journal Article, 2021, DOI
• Foley, C., Floudas, A., Canavan, M., Biniecka, M., MacDermott, E. J., Veale, D. J., Mullan, R. H., Killeen, O. G., Fearon, U., Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome"Associated Arthritis, Arthritis & Rheumatology, 72, (4), 2020, p677-686Journal Article, 2020, DOI
• Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022Journal Article, 2022
• Hanlon MM, Canavan M, Barker BE, Fearon U., Metabolites as drivers and targets in Rheumatoid Arthritis., Clinical and experimental immunology, 2021Journal Article, 2021, DOI
• Canavan, M., McCarthy, C., Larbi, N.B., Dowling, J.K., Collins, L., O'Sullivan, F., Hurley, G., Murphy, C., Quinlan, A., Moloney, G., Darby, T., Macsharry, J., Kagechika, H., Moynagh, P., Melgar, S., Loscher, C.E., Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-"Bp50, Innate Immunity, 20, (7), 2014, p675-687Journal Article, 2014, DOI
• Nikiphorou E, Studenic P, Ammitzbøll CG, Canavan M, Jani M, Ospelt C, Berenbaum F, EMEUNET., Social media use among young rheumatologists and basic scientists: results of an international survey by the Emerging EULAR Network (EMEUNET)., Annals of the rheumatic diseases, 76, (4), 2017, p712-715Journal Article, 2017, DOI
• Nikiphorou E, Studenic P, Alunno A, Canavan M, Jani M, Berenbaum F, 'Twitterland': a brave new world?, Annals of the rheumatic diseases, 2017Journal Article, 2017, DOI
• Canavan M, Wade SM, Veale DJ, Fearon U, Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al., Annals of the rheumatic diseases, 2020Journal Article, 2020, DOI
• Canavan M, Marzaioli V, Bhargava V, Nagpal S, Gallagher P, Hurson C, Mullan R, Veale DJ, Fearon U, Functionally Mature CD1c⁺ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium., Frontiers in immunology, 2021Journal Article, 2021, DOI
• Viviana Marzaioli, Mary Canavan, Alex Donnolly, Siobhan Wade, Alexander Fraser, Tim O'Sullivan, Sinead Harney, Arthritis Ireland, Douglas J. Veale, Ursula Fearon, Knowledge of disease, diagnosis, adherence and impact of research in an Irish cohort of patients with inflammatory arthritis, HRB Open Research, 4, 2021, p60Journal Article, 2021, DOI
• Barker BE, Hanlon MM, Marzaioli V, Smith CM, Cunningham CC, Fletcher JM, Veale DJ, Fearon U, Canavan M., The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis., Frontiers in medicine, 10, 2023, p1029021Journal Article, 2023, DOI
• Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade SM, Hanlon M, Cunningham C, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao LY, Monaghan MG, Nagpal S, Veale DJ, Fearon U., Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis., Annals of the rheumatic diseases, 2022, pannrheumdis-2021-221761Journal Article, 2022, DOI
• Jenkins, B.J. and Blagih, J. and Ponce-Garcia, F.M. and Canavan, M. and Gudgeon, N. and Eastham, S. and Hill, D. and Hanlon, M.M. and Ma, E.H. and Bishop, E.L. and Rees, A. and Cronin, J.G. and Jury, E.C. and Dimeloe, S.K. and Veale, D.J. and Thornton, C.A. and Vousden, K.H. and Finlay, D.K. and Fearon, U. and Jones, G.W. and Sinclair, L.V. and Vincent, E.E. and Jones, N., Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity, Cell Metabolism, 35, (7), 2023, p1132-1146.e9Journal Article, 2023, DOI , URL
• Eve Draper, Clare M. Reynolds, Mary Canavan, Kingston H. Mills, Christine E. Loscher, and Helen M. Roche, Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma, Journal of Nutritional Biochemistry, 22, (8), 2011, p784-790Journal Article, 2011, DOI , URL , TARA - Full Text
• Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928Journal Article, 2013, DOI , TARA - Full Text
• Draper E, DeCourcey J, Higgins SC, Canavan M, McEvoy F, Lynch M, Keogh B, Reynolds C, Roche HM, Mills KH, Loscher CE, Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses., The Journal of nutritional biochemistry, 25, (7), 2014, p741-9Journal Article, 2014, DOI

• Title

  Restoration of Immunological Tolerance in Rheumatoid Arthritis via Metabolic Reprogramming
  Summary
  Funding Agency

  Trinity College Dublin Deans Award
  Date From

  01/01/2024
  Date To

  31/12/2024
• Title

  Restoration of Immunological Tolerance in Rheumatoid Arthritis via Metabolic Reprogramming of Dendritic Cells
  Summary
  Funding Agency

  HRB
• Title

  Ongoing Examination of the PD-1 Pathway throughout the Evolution of Rheumatoid Arthritis
  Summary
  Funding Agency

  Health Research Board
  Date From

  01/03/2023
  Date To

  01/03/2027
• Title

  Synovial T cell Memory Responses in Rheumatoid Arthritis Disease Progression
  Summary
  Funding Agency

  Irish Research Council
  Date From

  01/09/2023
  Date To

  31/08/202023
• Title

  Tissue Specific Immune Memory Mediates Disease Progression and Disease Flare in Rheumatoid Arthritis
  Summary
  Funding Agency

  SFI
  Date From

  01/09/2024
  Date To

  31/08/2028

Biochemistry and cell biology, Immunology,

• Chair: Research Advisory Committee | Irish Cancer Society I have full oversight and responsibility for all research activities and investments of the charity, and must ensure alignment with our strategic plan. May 2023 to Present Date
• Director: Centre for Arthritis and Rheumatic Diseases Responsible for strategic oversight in line with charities objectives. October 2020 - Present Date
• Director : Irish Cancer Society I am responsible for the overall governance of the charity and ensuring the charities strategic goals are reached. September 2021 to Present Date
• Organizer of Immunology Research Forum (IRF) Monthly seminar series in the area of Immunology hosted in Trinity Biomedical Sciences Institute December 2022 to Present Date
• Associate Editor: BMC Rheumatology BMC Rheumatology editorial member responsible as part of a team for manuscripts in the Pre-clinical and Translational Science section. May 2017 to Present Date