Professor Aisling Dunne

• Cox, D. J., Field, R. H., Williams, D. G., Baran, M., Bowie, A. G., Cunningham, C. and Dunne, A. , DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease, GLIA, 63, (5), 2015, p812-825Journal Article, 2015, DOI , TARA - Full Text
• Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919Journal Article, 2014, DOI , TARA - Full Text
• Corr E.M, Cunningham C.C, Dunne A, Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 251, 2016, p197 - 205Journal Article, 2016, DOI , URL
• Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2Journal Article, 2016, DOI , URL , TARA - Full Text
• Investigating inflammasome activation under conditions of cellular stress and injury in, Stress Responses: Methods and Protocols, 2015, pp105-113 , [Cunningham C.C, Corr E.M, Cox D.J, Dunne A]Book Chapter, 2015, DOI , URL
• Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240-Journal Article, 2016, DOI , URL
• Corr E.M, Cunningham C.C, Helbert L, McCarthy G.M, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Research and Therapy, 19, (1), 2017, p23-Journal Article, 2017, DOI , URL , TARA - Full Text
• Cunniffe G.M, Díaz-Payno P.J, Ramey J.S, Mahon O.R, Dunne A, Thompson E.M, O'Brien F.J, Kelly D.J, Growth plate extracellular matrix-derived scaffolds for large bone defect healing, European Cells and Materials, 33, 2017, p130 - 142Journal Article, 2017, DOI , URL , TARA - Full Text
• Mahon, O.R. and O'Hanlon, S. and Cunningham, C.C. and McCarthy, G.M. and Hobbs, C. and Nicolosi, V. and Kelly, D.J. and Dunne, A., Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner, Acta Biomaterialia, 65, 2018, p426-435Journal Article, 2018, DOI , URL
• Cunniffe GM, Díaz-Payno PJ, Sheehy EJ, Critchley SE, Almeida HV, Pitacco P, Carroll SF, Mahon OR, Dunne A, Levingstone TJ, Moran CJ, Brady RT, O'Brien FJ, Brama PAJ, Kelly DJ, Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials. , 188, 2019, p63-73Journal Article, 2019, DOI , TARA - Full Text
• Campbell, N.K. and Fitzgerald, H.K. and Malara, A. and Hambly, R. and Sweeney, C.M. and Kirby, B. and Fletcher, J.M. and Dunne, A., Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: Relevance for psoriasis treatment, Scientific Reports, 8, (1), 2018, p10287 -Journal Article, 2018, DOI , URL , TARA - Full Text
• Mahon, O.R. and Dunne, A., Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets, Frontiers in Immunology, 9, 2018Review, 2018, URL , TARA - Full Text
• McCarthy, G.M. and Dunne, A., Calcium Crystal Deposition Diseases - beyond gout, Nature Reviews Rheumatology, 14, 2018Review, 2018, URL
• Lopez Rodriguez A., Dunne, A. and Cunningham, C, Heterogeneous and Dynamic Astrocyte phenotypes in neurodegeneration and innate immunity, The Neuroscientist, 2018, pdoi:10.1177/1073858418809941Review, 2018, URL
• Díaz-Payno, P., Cunniffe G.M., Sheehy, E.J., Critchley, S., Almeida, H., Pitacco, P., Carroll, S., Mahon, O., Dunne, A., Levingstone, T., Moran, C., Brady, R., O'Brien, F.J., Brama, P. and Kelly, D.J., Layering of tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues, Biomaterials, 188, 2019, p63 - 73Journal Article, 2019
• Cunningham, C., Corr, E.M., McCarthy, G.M. and Dunne A, Intra-articular Basic Calcium Phosphate and Monosodium Urate Crystals Inhibit anti-osteoclastogenic Cytokine Signalling, Osteoarthritis and Cartilage, 24, 2016, p2141 - 2152Journal Article, 2016, URL , TARA - Full Text
• Aisling Dunne and Kingston Mills, 'TLR2 agonists and vaccines and uses thereof', European Patent Office, WO/2015/140234, 2015Patent, 2015, URL
• Cunningham, C., Corr, E., McCarthy, G., Dunne, A, Phenotypic and Functional Characteristics of Exosomes Isolated from Human Osteoarthritis (OA) Synovial Fluid. , Arthritis Rheumatol. , 2016 ACR/ACHP Annual Meeting, Washington, 68 (suppl 10)., 2016Conference Paper, 2016
• McCarthy, G., Cunningham, C., Corr, E., Dunne, A., Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ -induced Anti-Osteoclastogenic Signaling in human osteoclast precursors. , Arthritis Rheumatol. , 2015 ACR/ACHP Annual Meeting, San Francisco, 2015, 67 (suppl 10), 2015Conference Paper, 2015
• McCarthy, G., Mills, E., Mill, K, Dunne, A., Osteoarthritis-Associated Basic Calcium Phosphate Crystals Induce IL-1, IL-18 and S100A8 Production in A Tyrosine Kinase Dependent Manner. , Arthritis Rheumatol. , 2012 ACR/ACHP Annual Meeting, Atlanta, 2012, 2012Conference Paper, 2012
• Nazmi, A., Field, R.H., Griffin, E.W., Haugh, O., Hennessy, E., Cox, D., Reis, R., Tortorelli, L., Murray, C.L., Lopez-Rodriguez, A.B., Lavelle, E.C., Dunne, A. and Cunningham,C. , Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression, Glia, 67, 2019, p1254 - 1276Journal Article, 2019, DOI , TARA - Full Text
• Cunningham, C. and Dunne, A. and Lopez-Rodriguez, A.B., Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity, Neuroscientist, 2019, p455-474Journal Article, 2019, DOI , URL , TARA - Full Text
• Browe, D.C. and Mahon, O.R. and Díaz-Payno, P.J. and Cassidy, N. and Dudurych, I. and Dunne, A. and Buckley, C.T. and Kelly, D.J., Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering, Journal of Biomedical Materials Research - Part A, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Campbell, N.K. and Fitzgerald, H.K. and Fletcher, J.M. and Dunne, A., Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1, Frontiers in Immunology, 10, (MAR), 2019, p00345-Journal Article, 2019, DOI , URL , TARA - Full Text
• Silveira, A.A.A. and Mahon, O.R. and Cunningham, C.C. and Corr, E.M. and Mendonça, R. and Saad, S.T.O. and Costa, F.F. and Dunne, A. and Conran, N., S100A8 acts as an autocrine priming signal for heme-induced human MÏ. pro-inflammatory responses in hemolytic inflammation, Journal of Leukocyte Biology, 106, (1), 2019, p35-43Journal Article, 2019, DOI , URL
• A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451Journal Article, 2003, DOI , TARA - Full Text
• L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9Journal Article, 2003, DOI , URL
• E. K. Brint, D. Xu, H. Liu, A. Dunne, A. N. McKenzie, L. A. O'Neill and F. Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nature immunology, 5, (4), 2004, p373-379Journal Article, 2004, DOI , URL
• K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83Journal Article, 2001, DOI , URL
• A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3Review, 2003, DOI , URL
• Mahon, O.R. and Kelly, D.J. and McCarthy, G.M. and Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization, Osteoarthritis and Cartilage, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Campbell NK, Williams DG, Fitzgerald HK, Barry PJ, Cunningham CC, Nolan DP, Dunne A., Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages , Frontiers in Immunology-Microbial Immunology, 11, 2019Journal Article, 2019
• O'Rourke SA, Dunne A, Monaghan MG., The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling., Frontiers in cardiovascular medicine, 6, 2019, p101Journal Article, 2019, DOI , TARA - Full Text
• Olwyn R. Mahon, David C. Brow, Tomas Gonzalez-Fernandez, Pierluca Pitaccoc, Ian T. Whelan, Stanislas Von E, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston. H. G. Mills , Daniel J. Kelly and Aisling Dunne, Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner, Biomaterials, 239, 2020, p119833-Journal Article, 2020, DOI , TARA - Full Text
• Fitzgerald, H.K.; O'Rourke, S.A.; Desmond, E.; Neto, N.G.B.; Monaghan, M.G.; Tosetto, M.; Doherty, J.; Ryan, E.J.; Doherty, G.A.; Nolan, D.P.; Fletcher, J.M.; Dunne, A, The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells, Antioxidants, 11, 2022, p164-Journal Article, 2022, DOI
• Shanley, L.C. and Mahon, O.R. and Kelly, D.J. and Dunne, A., Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages, Acta Biomaterialia, 133, 2021, p208-221Journal Article, 2021, DOI , URL , TARA - Full Text
• Nuno Neto, Sinead O'Rourke, Mimi Zhang, Hannah Fitzgerald, Aisling Dunne and Michael Monaghan, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, eLife, 11, 2022, pe77373Journal Article, 2022
• Dunne A and O'Neill LA, Adaptor usage and Toll-like receptor signaling specificity, FEBS Lett., 579, (15), 2005Review, 2005, DOI , URL
• Shanley, L.C. and Mahon, O.R. and O'Rourke, S.A. and Neto, N.G.B. and Monaghan, M.G. and Kelly, D.J. and Dunne, A., Macrophage metabolic profile is altered by hydroxyapatite particle size, Acta Biomaterialia, 2023Journal Article, 2023, DOI , URL
• O'Rourke SA, Neto NGB, Devilly E, Shanley LC, Fitzgerald HK, Monaghan MG*, Dunne A.*, Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages, Atherosclerosis, 352, 2022, p35 - 45Journal Article, 2022, DOI
• Vozza, E.G. and Kelly, A.M. and Daly, C.M. and O†Rourke, S.A. and Carlile, S.R. and Morris, B. and Dunne, A. and McLoughlin, R.M., Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis, Cell Death Discovery, 10, (1), 2024Journal Article, 2024, DOI , URL
• Vozza, E.G. and Daly, C.M. and O'Rourke, S.A. and Fitzgerald, H.K. and Dunne, A. and McLoughlin, R.M., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival, mBio, 15, (1), 2024Journal Article, 2024, DOI , URL
• Shanley, L.C. and Fitzgerald, H.K. and O†Rourke, S.A. and Dunne, A., Endogenous drivers of altered immune cell metabolism, Experimental Biology and Medicine, 247, (24), 2022, p2192-2200Journal Article, 2022, DOI , URL
• Campbell, N.K. and Fitzgerald, H.K. and Dunne, A., Regulation of inflammation by the antioxidant haem oxygenase 1, Nature Reviews Immunology, 21, (7), 2021, p411-425Journal Article, 2021, DOI , URL
• McCarthy, G.M. and Dunne, A., Calcium crystals and auto-inflammation, Rheumatology (United Kingdom), 59, (1), 2020, p247-248Journal Article, 2020, DOI , URL
• Dunne, A. and Maple-GrÞdem, J. and Gargano, D. and Haslam, R.P. and Napier, J.A. and Chua, N.-H. and Russell, R. and MÞller, S.G., Modifying fatty acid profiles through a new cytokinin-based plastid transformation system, Plant Journal, 80, (6), 2014, p1131-1138Journal Article, 2014, DOI , URL
• Basak, I. and Pal, R. and Patil, K.S. and Dunne, A. and Ho, H.-P. and Lee, S. and Peiris, D. and Maple-GrÞdem, J. and Odell, M. and Chang, E.J. and Larsen, J.P. and MÞller, S.G., Arabidopsis AtPARK13, which confers thermotolerance, targets misfolded proteins, Journal of Biological Chemistry, 289, (21), 2014, p14458-14469Journal Article, 2014, DOI , URL
• Hogg, B.V. and Lelivelt, C.L.C. and Dunne, A. and Nguyen, K.-H. and Nugent, J.M., Plastid Transformation, 2010, 241-260ppBook, 2010, DOI , URL
• Dunne A and O'Neill L, New insights into the post-translational modification of Toll-like receptor, Journal of Endotoxin Research, 11, (6), 2005, p325 - 332Journal Article, 2005, DOI , URL
• Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495Journal Article, 2006, DOI , TARA - Full Text
• Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528Journal Article, 2007, DOI , TARA - Full Text
• Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377Journal Article, 2007, DOI , TARA - Full Text
• Mills KH, Dunne A, Immune modulation: IL-1, master mediator or initiator of inflammation, Nature Medicine, 15, (12), 2009, p1363-1364Review, 2009, DOI , TARA - Full Text
• Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995Journal Article, 2009, DOI
• Edward Franklin, Seamus Browne, Jerrard Hayes, Coilin Boland, Aisling Dunne, Gordon Elliot, and Timothy J. Mantle, Activation of biliverdin-IXα reductase by inorganic phosphate and related anions, Biochemical Journal, 405, 2007, p61-67Journal Article, 2007, DOI , URL , TARA - Full Text
• Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282Journal Article, 2010, DOI
• Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904Journal Article, 2010, DOI
• Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4., The Journal of biological chemistry, 278, (28), 2003, p26258-64Journal Article, 2003, DOI
• Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH, Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis., Journal of Immunology , 185, (3), 2010, p1711-9Journal Article, 2010, DOI , URL , TARA - Full Text
• Carpenter S, Wochal P, Dunne A, O'Neill LA, Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL)., The Journal of Biological Chemistry, 286, (44), 2011, p38795-38804Journal Article, 2011, DOI , URL , TARA - Full Text
• Dunne A, Marshall NA, Mills KH, TLR based therapeutics., Current opinion in pharmacology, 11, (4), 2011, p404-11Review, 2011, DOI
• Aisling Dunne, Neil Marshall, Kingston Mills, Targeting Toll-like receptors, by Dunne, A., Marshall N.M. and Mills, K.H. , Current Opinion Pharmacology, 11, 2011, p404-11Review, 2011
• Aisling Dunne, Inflammasome activation: from inflammatory disease to infection, Biochemical Society Transactions, 39, 2011Review, 2011, DOI , URL , TARA - Full Text
• Aisling Dunne, Orla Cunningham, Timothy Mantle, Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites, Journal of Biological chemistry, 275, 2000, p19009-Journal Article, 2000
• Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase., Clinical immunology (Orlando, Fla.), 144, (3), 2012, p228-236Journal Article, 2012, DOI
• Franklin, E., Mantle, T., Dunne, A., Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway, Biochimica et Biophysica Acta - Proteins and Proteomics, 1834, (12), 2013, p2573-2578Journal Article, 2013, DOI
• Miggin, S.M., PÃ¥lsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J., Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104), Proceedings of the National Academy of Sciences of the United States of America, 110, (43), 2013, p17600Journal Article, 2013, DOI
• Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP in, 2013, pp9-18 , [Westwell-Roper, C., Dunne, A., Kim, M.L., Verchere, C.B., Masters, S.L.]Book Chapter, 2013, DOI
• Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH, A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine., Mucosal immunology, 8, (3), 2015, p607-617Journal Article, 2015, DOI

In recent decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), which are conserved microbial structures sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns (DAMPs). The sterile inflammation that ensues either resolves the initial insult or leads to disease. A key focus of my research has been to identify the mechanisms via which PAMPs and DAMPs activate specific host immune responses and to identify new strategies to treat inflammatory disease. Our work to date on novel PAMPs, for example from Bordetella pertussis (the causative agent of whooping cough), has implications for vaccine design. We have identified a vaccine candidate that acts both as an adjuvant (to boost innate immune responses) and as an antigen (to target the adaptive immune system). Antigens containing both of these properties have never before been described for B.pertussis. This work has been patent protected and we are taking steps to commercialise the products of this research. My work in the field of sterile inflammation has focused on DAMPs that are implicated in osteoarthritis (OA), atherosclerosis and neurodegenerative disease. In particular, my group has carried out a significant amount of work delineating the molecular and inflammatory pathways driven by OA disease-associated particulates. We have identified potential new therapeutic targets to treat OA-associated inflammation and have now extended our work to assess immune responses to orthopedic implant materials which can cause a form of sterile inflammation known as periprosthetic osteolysis. Furthermore, we are collaborating extensively with the Trinity Centre for Engineering and AMBER to assess immune responses to novel biomaterials which are intended to replace traditional biomaterials.

Other clinical medicine, Medical and biomedical engineering, Immunology,

• Trinity Innovation Awards 2018: 'Inventors' Category Nominee. This category recognized academics whose innovative research has led to commercial success. Dec 2018

• Standing Committee Member: Irish Society of Immunology present
• British Society of Immunology Member

• External PhD Examiner - NUI Maynooth 2014
• External PhD Examiner - University of Cambridge 2013
• External PhD Examiner - NUI Maynooth 2015