Professor Gregory Atkins

• G.J. Atkins, M.N. Fleeton, J. W. P. Smyth, B. J. Sheahan, Alphaviruses and their derived vectors as anti-tumor agents, Current Cancer Drug Targets, 4, (7), 2004, p597 - 607Journal Article, 2004, URL
• J.W.P. Smyth, M.N. Fleeton, B.J. Sheahan, G. J. Atkins , Treatment of rapidly growing K-BALB and CT26 mouse tumours using Semliki Forest virus and its derived vector , Gene Therapy, 12, (2), 2005, p147 - 159Journal Article, 2005, DOI , URL
• Atkins, G.J. and Sheahan, B.J., Molecular determinants of alphavirus neuropathogenesis in mice, Journal of General Virology, 97, (6), 2016, p1283-1296Journal Article, 2016, DOI , URL
• Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363Journal Article, 2005
• CP Chikkanna-Gowda, BJ Sheahan, MN Fleeton and GJ Atkins, Regression of mouse tumours and inhibition of metastases following administration of a Semliki Forest virus vector with enhanced expression of IL-12, Gene Therapy, 12, (16), 2005, p1253 - 1263Journal Article, 2005, DOI , URL
• Galbraith SE, Sheahan BJ, Atkins GJ, Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulence, JOURNAL OF GENERAL VIROLOGY, 87, (Part 4), 2006, p937 - 947Journal Article, 2006, DOI , URL
• Fleeton MN, Gowda CPC, Atkins GJ, Antiangiogenic tumour therapy using Semliki forest virus vectors encoding IL-12, JOURNAL OF GENE MEDICINE, 6, (9), 2004, pS31 - S31Journal Article, 2004
• Mabruk MJ, Sheahan BJ, Atkins GJ. , The effect of infection of hatched blastocyst bovine embryos with border disease and bovine viral diarrhea viruses, Southeast Asian Journal of Tropical Medicine and Public Health, 37, 2006, p113 - 119Journal Article, 2006
• Chikkanna-Gowda CP, McNally S, Sheahan BJ, Fleeton MN, Atkins GJ, Inhibition of murine K-BALB and CT26 tumour growth using a Semliki Forest virus vector with enhanced expression of IL-18, Oncology Reports, 16, 2006, p713 - 719Journal Article, 2006, URL
• Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. , The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo., Oncology Reports, 14, 2005, p1357 - 1363Journal Article, 2005, URL
• Atkins, G. J. , Sheahan, B. J. and Liljeström, P., The molecular pathogenesis of Semliki Forest virus: a model virus made useful?, Journal of General Virology, 80, 1999, p2287-2297Review, 1999, URL
• Atkins, G. J., Daly, E. A., Sheahan, B. J., Higgins, D. G. & Sharp, P. M. , Multiple sclerosis and molecular mimicry., Neuropathology and Applied Neurobiology , 16, 1990, p179 - 180Journal Article, 1990
• J A Lyons, B J Sheahan, S E Galbraith, R Mehra, G J Atkins and M N Fleeton, Inhibition of angiogenesis by a Semliki Forest virus vector expressing VEGFR-2 reduces tumour growth and metastasis in mice, Gene Therapy, 14, 2007, p503 - 513Journal Article, 2007, DOI , URL
• Kelly BJ, Fleeton MN, Atkins GJ., Potential of Alphavirus Vectors in the Treatment of Advanced Solid Tumors, Recent patents on anti-cancer drug discovery, 2, 2007, p159-166Review, 2007
• Callagy S.J., Kelly B.J., Fleeton M.N., Sheahan B.J., Galbraith S.E., and Atkins, G. J., Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus., Vaccine, 25, (43), 2007, p7481 - 7490Journal Article, 2007, DOI
• Galbraith, S.E., Atkins, G. J., Sheahan, B. J., A Semliki Forest virus replication competent vector with enhanced biosafety., 2007, WO2007/102140Patent, 2007
• GLASGOW, GM, SHEAHAN, BJ, ATKINS, GJ, WAHLBERG, JM, SALMINEN, A, LILJESTROM, P, 2 MUTATIONS IN THE ENVELOPE GLYCOPROTEIN-E2 OF SEMLIKI FOREST VIRUS AFFECTING THE MATURATION AND ENTRY PATTERNS OF THE VIRUS ALTER PATHOGENICITY FOR MICE, VIROLOGY, 185, 1991, p741 - 748Journal Article, 1991
• OCONNOR, DP, A HIGH DEGREE OF CHROMOSOMAL INSTABILITY AT 13Q14 IN CUTANEOUS SQUAMOUS CELL CARCINOMAS: INDICATION FOR A ROLE OF A TUMOUR SUPPRESSOR GENE OTHER THAN RB, JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 54, 2001, p165 - 169Journal Article, 2001, URL
• MABRUK, MJEMF, A RAPID MICROWAVE-IN SITU HYBRIDIZATION METHOD FOR THE DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA: COMPARISON WITH IMMUNOHISTOCHEMISTRY, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 25, 1996, p170 - 176Journal Article, 1996, DOI , URL
• MORRIS-DOWNES, MM, A RECOMBINANT SEMLIKI FOREST VIRUS PARTICLE VACCINE ENCODING THE PRME AND NSL PROTEINS OF LOUPING ILL VIRUS IS EFFECTIVE IN A SHEEP CHALLENGE MODEL, VACCINE, 19, 2001, p3877 - 3884Journal Article, 2001, DOI , URL
• MABRUK, MJEMF, A SIMPLE AND RAPID TECHNIQUE FOR THE DETECTION OF EPSTEIN-BARR VIRUS DNA IN HIV-ASSOCIATED ORAL HAIRY LEUKOPLAKIA BIOPSIES, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 29, 2000, p118 - 122Journal Article, 2000, DOI , URL
• GLASGOW, GM, A SINGLE AMINO-ACID CHANGE IN THE E2 SPIKE PROTEIN OF A VIRULENT-STRAIN OF SEMLIKI-FOREST VIRUS ATTENUATES PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 75, 1994, p663 - 668Journal Article, 1994, URL
• OCONNOR, DP, ALTERED P53 EXPRESSION IN BENIGN AND MALIGNANT SKIN LESIONS FROM RENAL TRANSPLANT RECIPIENTS AND IMMUNOCOMPETENT PATIENTS WITH SKIN CANCER: CORRELATION WITH HUMAN PAPILLOMAVIRUSES?, DIAGNOSTIC MOLECULAR PATHOLOGY, 10, 2001, p190 - 199Journal Article, 2001, URL
• ATKINS, GJ, BALLUZ, IM, GLASGOW, GM, MABRUK, MJEMF, NATALE, VAI, SMYTH, JMB, SHEAHAN, BJ, ANALYSIS OF THE MOLECULAR-BASIS OF NEUROPATHOGENESIS OF RNA VIRUSES IN EXPERIMENTAL-ANIMALS - RELEVANCE FOR HUMAN-DISEASE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 20, 1994, p91 - 102Journal Article, 1994
• DOMEGAN, LM, ATKINS, GJ., APOPTOSIS INDUCTION BY THE THERIEN AND VACCINE RA27/3 STRAINS OF RUBELLA VIRUS CAUSES DEPLETION OF OLIGODENDROCYTES FROM RAT NEURAL CELL CULTURES, JOURNAL OF GENERAL VIROLOGY, 83, 2002, p2135 - 2143Journal Article, 2002, URL
• KEOGH, B, AVIRULENT SEMLIKI FOREST VIRUS REPLICATION AND PATHOLOGY IN THE CENTRAL NERVOUS SYSTEM IS ENHANCED IN IL-12-DEFECTIVE AND REDUCED IN IL-4-DEFECTIVE MICE: A ROLE FOR TH1 CELLS IN THE PROTECTIVE IMMUNITY, JOURNAL OF NEUROIMMUNOLOGY, 125, 2002, p15 - 22Journal Article, 2002, DOI , URL
• SAMMIN, DJ, CELL DEATH MECHANISMS IN THE OLFACTORY BULB OF RATS INFECTED INTRANASALLY WITH SEMLIKI FOREST VIRUS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 25, 1999, p236 - 243Journal Article, 1999, DOI , URL
• BALLUZ, IM, FARRELL, MA, KAY, E, STAUNTON, MJ, KEATING, JN, SHEILS, O, COSBY, SL, MABRUK, MJEMF, SHEAHAN, BJ, ATKINS, GJ, COLOCALISATION OF HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN CYTOMEGALOVIRUS INFECTION IN BRAIN AUTOPSY TISSUE FROM AIDS PATIENTS, IRISH JOURNAL OF MEDICAL SCIENCE, 165, 1996, p133 - 138Journal Article, 1996
• GLASGOW, GM, DEATH MECHANISMS IN CULTURED CELLS INFECTED BY SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1559 - 1563Journal Article, 1997, URL
• SHEAHAN, BJ, BARRETT, PN, ATKINS, GJ, DEMYELINATION IN MICE RESULTING FROM INFECTION WITH A MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 53, 1981, p129 - 136Journal Article, 1981
• MABRUK, MJEMF, DETECTION OF EPSTEIN-BARR-VIRUS DNA IN TONGUE TISSUES FROM AIDS AUTOPSIES WITHOUT CLINICAL-EVIDENCE OF ORAL HAIRY LEUKOPLAKIA, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 24, 1995, p109 - 112Journal Article, 1995, DOI , URL
• ATKINS, GJ, CARTER, J, SHEAHAN, BJ, EFFECT OF ALPHAVIRUS INFECTION ON MOUSE EMBRYOS, INFECTION AND IMMUNITY, 38, 1982, p1285 - 1290Journal Article, 1982
• Natale, V. A. I., Sheahan, B. J. & Atkins, G. J. , EFFECT OF INFECTION WITH RUBELLA-VIRUS ON THE DEVELOPMENT OF RAT CEREBELLAR CELLS IN CULTURE. Neuropathology and Applied Neurobiology 19, 530-534., 1993, -Miscellaneous, 1993
• MABRUK, MJEMF, GLASGOW, GM, FLACK, AM, FOLAN, JC, BANNIGAN, JG, SMYTH, JMB, OSULLIVAN, MA, SHEAHAN, BJ, ATKINS, GJ, EFFECT OF INFECTION WITH THE TS22 MUTANT OF SEMLIKI FOREST VIRUS ON DEVELOPMENT OF THE CENTRAL NERVOUS-SYSTEM IN THE FETAL MOUSE, JOURNAL OF VIROLOGY, 63, 1989, p4027 - 4033Journal Article, 1989
• GLASGOW, G, ATKINS, G.J., EFFECT OF PERSISTENT INFECTION ON THE GROWTH OF TUMOR-CELLS IN MICE, Irish Jurnal of Medical Science, 1983, 152, 1983, pp253 - 253Meeting Abstract, 1983
• BARRETT, PN, ESTABLISHMENT OF PERSISTENT INFECTION IN MOUSE CELLS BY SINDBIS VIRUS AND ITS TEMPERATURE-SENSITIVE MUTANTS, JOURNAL OF GENERAL VIROLOGY, 54, 1981, p57 - 65Journal Article, 1981, URL
• MCKENNA, BM, FORMATION OF INFECTIOUS PANCREATIC NECROSIS VIRUS-LIKE PARTICLES FOLLOWING EXPRESSION OF SEGMENT A BY RECOMBINANT SEMLIKI FOREST VIRUS, MARINE BIOTECHNOLOGY, 3, 2001, p103 - 110Journal Article, 2001, DOI , URL
• MABRUK, MJEMF, IN-SITU HYBRIDIZATION AND THE POLYMERASE CHAIN-REACTION (PCR) IN THE ANALYSIS OF BIOPSIES AND EXFOLIATIVE CYTOLOGY SPECIMENS FOR DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA (OHL), JOURNAL OF ORAL PATHOLOGY & MEDICINE, 23, 1994, p302 - 308Journal Article, 1994, DOI , URL
• MURPHY, AM, INDUCTION OF APOPTOSIS IN BCL-2-EXPRESSING RAT PROSTATE CANCER CELLS USING THE SEMLIKI FOREST VIRUS VECTOR, INTERNATIONAL JOURNAL OF CANCER, 94, 2001, p572 - 578Journal Article, 2001, DOI , URL
• HEARNE, AM, INFECTION OF CULTURED EARLY MOUSE EMBRYOS WITH SEMLIKI FOREST AND RUBELLA VIRUSES, JOURNAL OF GENERAL VIROLOGY, 67, 1986, p1091 - 1098Journal Article, 1986, URL
• MURPHY, AM, INHIBITION OF HUMAN LUNG CARCINOMA CELL GROWTH BY APOPTOSIS INDUCTION USING SEMLIKI FOREST VIRUS RECOMBINANT PARTICLES, GENE THERAPY, 7, 2000, p1477 - 1482Journal Article, 2000, URL
• HEARNE, AM, ISOLATION AND PRELIMINARY CHARACTERIZATION OF SEMLIKI FOREST VIRUS MUTANTS WITH ALTERED PATHOGENICITY FOR MOUSE EMBRYOS, JOURNAL OF GENERAL VIROLOGY, 68, 1987, p107 - 113Journal Article, 1987, URL
• DONNELLY, SM, LONG-TERM EFFECTS OF SEMLIKI FOREST VIRUS INFECTION IN THE MOUSE CENTRAL NERVOUS SYSTEM, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 23, 1997, p235 - 241Journal Article, 1997, DOI , URL
• ATKINS, GJ, SHEAHAN, BJ, LILJESTROM, P, MANIPULATION OF THE SEMLIKI FOREST VIRUS GENOME AND ITS POTENTIAL FOR VACCINE CONSTRUCTION, MOLECULAR BIOTECHNOLOGY, 5, 1996, p33 - 38Journal Article, 1996
• SAMMIN, DJ, SHEAHAN, BJ, ATKINS, GJ, MECHANISMS OF CELL DEATH IN THE CNS OF WEANLING RATS INFECTED WITH SEMLIKI FOREST VIRUS, IRISH VETERINARY JOURNAL, 50, 1997, p365 - 365Journal Article, 1997
• ATKINS, GJ, MABRUK, MJEMF, GLASGOW, GM, GRIFFIN, AM, SHEAHAN, BJ, MECHANISMS OF VIRAL TERATOGENESIS, REVIEWS IN MEDICAL VIROLOGY, 5, 1995, p75 - 86Journal Article, 1995
• ATKINS, GJ, MOONEY, DA, FAHY, DA, NG, SH, SHEAHAN, BJ, MULTIPLICATION OF RUBELLA AND MEASLES VIRUSES IN PRIMARY RAT NEURAL CELL-CULTURES - RELEVANCE TO A POSTULATED TRIGGERING MECHANISM FOR MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 17, 1991, p299 - 308Journal Article, 1991
• SMYTH, JMB, MULTIPLICATION OF VIRULENT AND DEMYELINATING SEMLIKI FOREST VIRUS IN THE MOUSE CENTRAL-NERVOUS-SYSTEM - CONSEQUENCES IN BALB/C AND SJL MICE, JOURNAL OF GENERAL VIROLOGY, 71, 1990, p2575 - 2583Journal Article, 1990, URL
• SHEAHAN, BJ, GATES, MC, CAFFREY, JF, ATKINS, GJ, OLIGODENDROCYTE INFECTION AND DEMYELINATION PRODUCED IN MICE BY THE M9-MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 60, 1983, p257 - 265Journal Article, 1983
• OCONNOR, DP, P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER, JOURNAL OF CLINICAL PATHOLOGY, 54, 2001, p539 - 542Journal Article, 2001, DOI , URL , TARA - Full Text
• ATKINS, GJ, SHEAHAN, BJ, MOONEY, DA, PATHOGENICITY OF SEMLIKI FOREST VIRUS FOR THE RAT CENTRAL-NERVOUS-SYSTEM AND PRIMARY RAT NEURAL CELL-CULTURES - POSSIBLE IMPLICATIONS FOR THE PATHOGENESIS OF MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 16, 1990, p57 - 68Journal Article, 1990
• FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES ENCODING THE PRME OR NS1 PROTEINS OF LOUPING ILL VIRUS PROTECT MICE FROM LETHAL CHALLENGE, JOURNAL OF GENERAL VIROLOGY, 80, 1999, p1189 - 1198Journal Article, 1999, URL
• FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES EXPRESSING LOUPING ILL VIRUS ANTIGENS INDUCE A BETTER PROTECTIVE RESPONSE THAN PLASMID-BASED DNA VACCINES OR AN INACTIVATED WHOLE PARTICLE VACCINE, JOURNAL OF GENERAL VIROLOGY, 81, 2000, p749 - 758Journal Article, 2000, URL
• FLEETON, MN, SELF-REPLICATIVE RNA VACCINES ELICIT PROTECTION AGAINST INFLUENZA A VIRUS, RESPIRATORY SYNCYTIAL VIRUS, AND A TICKBORNE ENCEPHALITIS VIRUS, JOURNAL OF INFECTIOUS DISEASES, 183, 2001, p1395 - 1398Journal Article, 2001, URL
• ATKINS, GJ, SHEAHAN, BJ, SEMLIKE FOREST VIRUS NEUROVIRULENCE MUTANTS HAVE ALTERED CYTOPATHOGENICITY FOR CENTRAL NERVOUS-SYSTEM CELLS, INFECTION AND IMMUNITY, 36, 1982, p333 - 341Journal Article, 1982
• BERGLUND, P, SEMLIKI FOREST VIRUS EXPRESSION SYSTEM - PRODUCTION OF CONDITIONALLY INFECTIOUS RECOMBINANT PARTICLES, BIO-TECHNOLOGY, 11, 1993, p916 - 920Journal Article, 1993, DOI , URL
• MORRIS-DOWNES, MM, SEMLIKI FOREST VIRUS-BASED VACCINES: PERSISTENCE, DISTRIBUTION AND PATHOLOGICAL ANALYSIS IN TWO ANIMAL SYSTEMS, VACCINE, 19, 2001, p1978 - 1988Journal Article, 2001, DOI , URL
• Atkins, G, J,, Sheahan, B. J., Dimmock, N. J., , SEMLIKI FOREST VIRUS-INFECTION OF MICE - A MODEL FOR GENETIC AND MOLECULAR ANALYSIS OF VIRAL PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p395-408Review, 1985, URL
• TARBATT, CJ, SEQUENCE ANALYSIS OF THE AVIRULENT, DEMYELINATING A7 STRAIN OF SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1551 - 1557Journal Article, 1997, URL
• MABRUK, MJEMF, TERATOGENICITY OF THE SEMLIKI FOREST VIRUS MUTANT TS22 FOR THE FETAL MOUSE - INDUCTION OF SKELETAL AND SKIN DEFECTS, JOURNAL OF GENERAL VIROLOGY, 69, 1988, p2755 - 2762Journal Article, 1988, URL
• ATKINS, GJ, THE AVIRULENT-A7 STRAIN OF SEMLIKI FOREST VIRUS HAS REDUCED CYTOPATHOGENICITY FOR NEURO-BLASTOMA CELLS COMPARED TO THE VIRULENT-L10 STRAIN, JOURNAL OF GENERAL VIROLOGY, 64, 1983, p1401 - 1404Journal Article, 1983, URL
• Sheahan, B.J., Moore, M., Atkins, G.J., The pathogenicity of louping Ill virus for mice and lambs , Journal of Comparative Pathology , 126, 2002, p137 - 146Journal Article, 2002, DOI , URL
• GATES, MC, THE PATHOGENICITY OF THE A7-STRAIN, M9-STRAIN AND L10-STRAIN OF SEMLIKI FOREST VIRUS FOR WEANLING MICE AND PRIMARY MOUSE-BRAIN CELL-CULTURES, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p2365 - 2373Journal Article, 1985, URL
• GATES, MC, THE PATHOGENICITY OF THE M9 MUTANT OF SEMLIKI FOREST VIRUS IN IMMUNE-COMPROMISED MICE, JOURNAL OF GENERAL VIROLOGY, 65, 1984, p73 - 80Journal Article, 1984, URL
• GLASGOW, GM, THE SEMLIKI FOREST VIRUS VECTOR INDUCES P53-INDEPENDENT APOPTOSIS, JOURNAL OF GENERAL VIROLOGY, 79, 1998, p2405 - 2410Journal Article, 1998, URL
• Atkins, G. J., Mc Quaid, S., Morris-Downes, M. M., Galbraith, S. E., Amor, S., Cosby, S. L. and Sheahan, B. J. , TRANSIENT VIRUS INFECTION AND MULTIPLE SCLEROSIS, REVIEWS IN MEDICAL VIROLOGY, 10, 2000, p291-303Review, 2000, DOI , URL
• BALLUZ, IM, GLASGOW, GM, KILLEN, HM, MABRUK, MJMEF, SHEAHAN, BJ, ATKINS, GJ, VIRULENT AND AVIRULENT STRAINS OF SEMLIKI FOREST VIRUS SHOW SIMILAR CELL TROPISM FOR THE MURINE CENTRAL-NERVOUS-SYSTEM BUT DIFFER IN THE SEVERITY AND RATE OF INDUCTION OF CYTOLYTIC DAMAGE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 19, 1993, p233 - 239Journal Article, 1993
• Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J, Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: A role for Th1 cells in the protective immunity , Journal of Neuroimmunology , 125, 2002, p15 - 22Journal Article, 2002, DOI
• Atkins, G. J. & Hayes, A. E. , Surface changes in a strain of Rhizobium trifolii on mutation to bacteriophage resistance , Journal of General Microbiology , 73, 1972, p273 - 278Journal Article, 1972
• Atkins, G. J., Some bacteriophages active against Rhizobium trifolii strain W19., Journal of Virology , 12, 1973, p149 - 156Journal Article, 1973, URL
• Atkins, G. J. , Isolation and preliminary characterization of temperature-sensitive mutants of rhizobiophage c, Journal of Virology , 12, 1973, p157 - 164Journal Article, 1973, URL
• Atkins, G. J. & Avery, R. J, DNA homology, redundancy and genome size of four Rhizobium bacteriophages., Journal of General Virology , 24, 1974, p301 - 306Journal Article, 1974, URL
• Atkins, G. J., Samuels, J. & Kennedy, S. I. T, Isolation and preliminary characterization of temperature-sensitive mutants of Sindbis virus strain AR339, Journal of General Virology , 25, 1974, p371 - 380Journal Article, 1974, URL
• Atkins, G. J., Johnstone, M. D., Westmacott, L. & Burke, D. C, Induction of interferon in chick cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology, 25, 1974, p381 - 390Journal Article, 1974, URL
• Atkins, G. J. & Lancashire, C. L., Interferon induction by temperature-sensitive mutants of Sindbis virus: its relationship to virus-specified double-stranded RNA synthesis and cytopathic effect, Journal of General Virology , 30, 1976, p157 - 165Journal Article, 1976, URL
• Atkins, G. J., The effect of infection with Sindbis virus and its temperature-sensitive mutants on cellular protein and DNA synthesis, Virology, 71, 1976, p593 - 597Journal Article, 1976
• Atkins, G. J, Cytopathogenicity of temperature-sensitive mutants of Sindbis virus, FEMS Microbiology Letters , 2, 1977, p51 - 55Journal Article, 1977
• Atkins, G. J., Moynihan, M., Arbuthnott, E. & Hartigan, P. J., Detection of C-type virus in immunologically reactive ovine lymph nodes, FEMS Microbiology Letters , 2, 1977, p75 - 77Journal Article, 1977
• Brezeski, H., Clegg, J. C. S., Atkins, G. J. & Kennedy, S. I. T., Regulation of the synthesis of Sindbis virus-specified RNA: role of the virion core protein, Journal of General Virology , 38, 1978, p461 - 470Journal Article, 1978, URL
• Barrett, P. N. & Atkins, G. J., Virulence of temperature-sensitive mutants of Sindbis virus in neonatal mice. , Infection and Immunity , 26, 1979, p848 - 852Journal Article, 1979
• Atkins, G. J., Establishment of persistent infection in BHK-21 cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology , 45, 1979, p201 - 207Journal Article, 1979, URL
• Sheahan, B. J., Atkins, G. J., Russell, R. J. & O'Connor, J. P., Observations on two cases of histiolymphocytic lymphosarcoma in the subcutis of the horse, Veterinary Pathology , 17, 1980, p123 - 133Journal Article, 1980
• Barrett, P. N., Sheahan, B. J. & Atkins, G. J. , Isolation and preliminary characterization of mutants of Semliki Forest virus with altered virulence, Journal of General Virology , 49, 1980, p141 - 148Journal Article, 1980, URL
• Atkins, G. J., Multiple sclerosis - is a virus involved? , Viral Therapeutics , 3, 1983, p1 - 2Journal Article, 1983
• Atkins, G. J., Virus persistence in the central nervous system, Viral Therapeutics , 4, 1983, p6 - 7Journal Article, 1983
• Gates, M. C., Sheahan, B. J., O'Sullivan, M. A. & Atkins, G. J., The pathogenicity of the A7, M9 and L10 strains of Semliki Forest virus for weanling mice and primary mouse brain cell cultures., Journal of General Virology , 66, 1985, p2365 - 2373Journal Article, 1985, URL
• Frey, T., Mitchell, L. A., Best, J. M., Schalasta, G., Katow, S., Wolinsky, J. S., Gillam, S., Atkins, G. J., Chantler, J. & Nakhasi, H. L., of an international meeting on rubella vaccines and vaccination, 9 August 1993, Glasgow, United Kingdom, Journal of Infectious Diseases , 170, 1994, p507 - 509Journal Article, 1994
• Mabruk, M. J. E. M. F., Flint, S. R., Coleman, D. C., Toner, M. and Atkins, G. J. , Diagnosis and treatment of oral hairy leukoplakia, of the European Academy of Dermatology and Venereology, 6, 1996, p127 - 134Journal Article, 1996, DOI , URL
• Sheahan, B. J., Ibrahim, M. A., and Atkins, G. J. , Demyelination of olfactory pathways in mice following intranasal infection with the avirulent A7 strain of Semliki Forest virus., European Journal of Veterinary Pathology , 2, 1996, p117 - 125Journal Article, 1996
• Caffrey, J. F., Dudgeon, A. M., Donnelly, W. J. C., Atkins, G. J. and Sheahan, B. J. , Morphometric analysis of growth retardation in foetal lambs following experimental infection of pregnant ewes with border disease virus, Research in Veterinary Science , 62, 1997, p245 - 248Journal Article, 1997, DOI , URL
• Molecular approaches to fish vaccine design in, editor(s)A. Barnes, G. Davidson, M. Hiney and D. McIntosh , Methodology in Fish Disease Research, Aberdeen, Scotland., Albion Press, 1998, pp161 - 166, [Vaughan, L.M., Fitzpatrick, R.M., McKenna B. and Atkins, G. J. ]Book Chapter, 1998
• Vaccination with recombinant suicidal DNA/RNA in, editor(s)O. Merten, P. Perrin & B. Griffithspp , New Developments and New Applications in Animal Cell Technology, Dordrecht., Kluwer Academic Publishers, 1998, pp583 - 590, [Berglund, P., Fleeton, M., Smerdou, C., Tubulekas, I., Sheahan, B. J., Atkins, G. J. & Liljeström, P]Book Chapter, 1998, DOI , URL
• Phenix, K. V., McKenna, B., Fitzpatrick, R., Vaughan, L., Atkins, G., Liljeström, P. & Todd, D., Cell culture evaluation of the Semliki Forest virus expression system as a novel approach for antigen delivery and expression in fish, Marine Biotechnology , 2, 2000, p27 - 37Journal Article, 2000, DOI , URL
• O'Connor, D. P., Kay, E. W., Leader, M., Murphy, G. M., Atkins, G. J. & Mabruk, M. J. E. M. F., A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: indication for a role of a tumour, Molecular Pathology , 54, 2001, p165 - 169Journal Article, 2001, URL
• Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190Journal Article, 2003, DOI , URL
• Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562Journal Article, 2003, DOI , URL
• Atkins, G. J. and Cosby, S. L, Is an improved measles-mumps-rubella vaccine necessary or feasible?, Critical Reviews in Immunology , 23, (4), 2003, p323 - 338Journal Article, 2003, DOI , URL
• Jerusalmi, A., Morris-Downes, M. M., Sheahan, B. J. and Atkins, G. J., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis., Molecular Therapy, 8, (6), 2003, p886 - 894Journal Article, 2003, URL
• Atkins, G. J., Mooris-Downes, M. M., Jerusalmi, A. and Sheahan, B. J. , An expression vector for the central nervous system, 2003, PCT/IE03/00089Patent, 2003
• Atkins, G. J., International Conference of Multiple Sclerosis Societies symposium, 1990Invited Talk, 1990
• Atkins, G. J., American Society for Virology symposium, 1991Invited Talk, 1991
• Atkins, G. J., Society for General Microbiology symposium, 1992Invited Talk, 1992
• Atkins, G. J., Society for General Microbiology symposium, 1994Invited Talk, 1994
• Atkins, G. J., Society for General Microbiology symposium, 1998Invited Talk, 1998
• Atkins, G. J., Techniques for gene manipulation, targeting and delivery in the nervous system , EU/FEBS course: , 2000Invited Talk, 2000
• Atkins, G. J., European Committee for Research and Treatment in Multiple Sclerosis 17th symposium , 2001Invited Talk, 2001
• Atkins, G. J., 5th Gene Delivery & Cellular Protein Expression Conference, Vienna, 2001Invited Talk, 2001
• Quinn,K, Galbraith, SE, Sheahan, BJ, Atkins, GJ., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-ß on the progression of experimental autoimmune encephalomyelitis., Molecular Medicine Reports., 1, (3), 2008, p335 - 342Journal Article, 2008, URL , TARA - Full Text
• Atkins GJ, Fleeton MN, Sheahan, BJ. , Therapeutic and prophylactic applications of alphavirus vectors., Expert Reviews in Molecular Medicine., 10, 2008, pe33Journal Article, 2008, DOI
• Piggott, J.M., Sheahan, B.J., Soden, D.M., O'Sullivan, G.C., Atkins, G.J., Electroporation of RNA stimulates immunity to an encoded reporter gene in mice , Molecular Medicine Reports, 2, (5), 2009, p753-756Journal Article, 2009, DOI
• Logue CH, Sheahan BJ, Atkins GJ, The 5' untranslated region as a pathogenicity determinant of Semliki Forest virus in mice., Virus genes, 36, (2), 2008, p313-21Journal Article, 2008, DOI
• Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190Journal Article, 2003, DOI , URL
• Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562Journal Article, 2003, DOI , URL
• Mabruk MJ, Flint SR, Toner M, Leonard N, Sheils O, Coleman DC, Atkins GJ., Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia., Journal of Oral Pathology and Medicine, 24, (3), 1995, p109-112Journal Article, 1995, DOI
• Mabruk MJ, Flint SR, Coleman DC, Shiels O, Toner M, Atkins GJ., A rapid microwave-in situ hybridization method for the definitive diagnosis of oral hairy leukoplakia: comparison with immunohistochemistry., Journal of Oral Pathology & Medicine, 25, (4), 1996, p170-176Journal Article, 1996, DOI
• Roche, F.P., Sheahan, B.J., O'Mara, S.M., Atkins, G.J., Semliki Forest virus-mediated gene therapy of the RG2 rat glioma, Neuropathology and Applied Neurobiology, 36, (7), 2010, p648-660Journal Article, 2010, DOI

• Chikungunya Virus (Ross) Complete Genome, Genbank, AF490259, 2002, [Logue CH, Atkins GJ]Item in dictionary or encyclopaedia, etc
• Semliki Forest Virus (L10) Complete Genome, Genbank, AY112987, 2002, [Logue,C., Mooney,D., Shanley,R. and Atkins,G.J.]Item in dictionary or encyclopaedia, etc
• Atkins, G. J., SGM workshop on Viral Vectors, 2003, EdinburghMeetings /Conferences Organised

Current research interests 1.Analysis of the molecular basis of alphavirus pathogenicity: We have suggested mechanisms of teratogenesis and neurovirulence of Semliki Forest virus at the cellular level and our current work is aimed at determination of the molecular control of pathogenesis. In this work we utilise infectious clones of SFV. By using chimeric virus construction and site-directed mutagenesis, we have shown that several mutations and sequences can influence viral pathogenesis. Current work involves analysis of the mechanisms of virus-induced death in neural cells and the involvement of virus proteins in this process. 2. Analysis of the mechanism of virus-induced demyelination and its relevance to multiple sclerosis: Present work is aimed at elucidating the role of cytokines, virus persistence and apoptosis in the process of demyelination. This work has been extended to include human rubella virus (a togavirus like SFV), and we have shown that rubella virus has similar tropism in neural cell culture to SFV. 3. Use of Semliki Forest virus as a vector in the construction of viral vaccines ,as a tumour therapy agent and as a CNS vector: Virus vaccines in current use have many disadvantages and in rare cases can cause disease. We are using a vector system, developed by workers at the Karolinska Institute in Stockholm with our help, to construct new virus vaccines. This is a collaborative project with the Karolinska Institute and the Department of Veterinary Pathology at UCD, and part of our work is concerned with improvement of the biosafety of the system. This work has recently been extended to the use of SFV as a cytotoxic cancer therapy agent, and to the development of SFV as a vector for the central nervous system. New virus vectors are currently being constructed and patented.

• Title

  Development of a replication competent RNA vector for the treatment of advanced solid tumours
  Summary

  € 243473
  Funding Agency

  Enterprise Ireland
  Date From

  2006
  Date To

  2009
• Title

  Treatment of glioma using an RNA gene therapy vector
  Summary

  € 160000
  Funding Agency

  Science Foundation Ireland
  Date From

  2005
  Date To

  2009
• Title

  Construction and development of a new prototype measles-mumps-rubella vaccine based on recombinant RNA
  Summary

  € 766846
  Funding Agency

  Science Foundation Ireland
  Date From

  2004
  Date To

  2008
• Title

  Therapy for MS
  Summary

  € 25125
  Funding Agency

  Multiple Sclerosis Society of Ireland
  Date From

  2005
  Date To

  2008
• Title

  Construction and development of novel and improved Semliki Forest virus vectors for RNA-based transient gene therapy
  Summary

  € 156321
  Funding Agency

  Science Foudation Ireland
  Date From

  2005
  Date To

  2008

• Fogarty International Fellow, Washington University, St. Louis, USA 1984
• EMBO Fellow, University of Helsinki, Finland 1980
• UICC Fellow, Karolinska Institute, Stockholm, Sweden 1975
• Fellow, Trinity College Dublin 1983

• European Society for Gene Therapy
• American Society for Microbiology
• British Society for Gene Therapy (founder member)
• International Society for Neurovirology (founder member).
• Society for General Microbiology

• Committee, Society for General Microbiology, Irish Branch 1978-1981, 1982-1985
• EU evaluation panel, Biotechnology Programme 1996, 1997
• Evaluation panel, Enterprise Ireland Basic Science Programme 1992,1998
• Member, WHO working group on Biosafety of Nucleic Acid Vaccines 1999-
• Interview panel, HRB Research Fellowships 2003
• Consultant for Alexander Harris, UK solicitors for vaccine-damaged children (also advisor to barristers involved in MMR litigation). 2001, 2002
• First and second stage evaluation panels, EU 5th Framework Programme 1999
• Health Research Board Committees: Mechanisms of Disease and North-South Collaboration 2000 - 2004
• Consultant for Environmental Protection Agency (industrial use of viral vectors) 1999, 2000, 2001, 2002
• Research Committee, Multiple Sclerosis Society of Ireland 1999-
• GMO Advisory Committee, Environmental Protection Agency 2001