Dr. Thomas Ryan
Clinical Senior Lecturer, Surgery
Publications and Further Research Outputs
Peer-Reviewed Publications
Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology., Platelets, 29, (3), 2018, p301 - 304
Ryan, T., Coakley, J.D., Martin-Loeches, I., Defects in innate and adaptive immunity in patients with sepsis and health care associated infection, Annals of Translational Medicine, 5, (22), 2017
Talento AF , Dunne K , Joyce EA , Palmer M , Johnson E , White PL , Springer J, Loeffler J, Ryan T, Collins, Rogers TR, A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit., Journal of Critical Care, (40), 2017, p119 - 127
Larkin, C.M., Santos-Martinez, M.-J., Ryan, T., Radomski, M.W., Sepsis-associated thrombocytopenia, Thrombosis Research, 141, 2016, p11-16
Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338
Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., 2015
Conroy MJ, Mac Nicholas R, Grealy R, Taylor M, Otegbayo JA, O'Dea S, Mulcahy F, Ryan T, Norris S, Doherty DG, Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-" or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection., Journal of viral hepatitis, 22, (3), 2015, p335-45
Jonker, W.R., Hanumanthiah, D., Ryan, T., Cook, T.M., Pandit, J.J., O'Sullivan, E.P., Who operates when, where and on whom? A survey of anaesthetic-surgical activity in Ireland as denominator of NAP5, Anaesthesia, 69, (9), 2014, p961-968
Grealy, R., White, M., Stordeur, P., Kelleher, D., Doherty, D.G., McManus, R., Ryan, T., Characterising cytokine gene expression signatures in patients with severe sepsis, Mediators of Inflammation, 2013, 2013, part. no. 164246
Rocha, C. and Woodward, M., Nutrients, 2012, 197-221pp
Mahabeleshwar, G.H., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S.M., Atkins, G.B., Wong, H.R., Lingrel, J.B., Jain, M.K., The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock, Immunity, 35, (1), 2011
White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T, Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression., Chest, 139, (3), 2011, p626-32
Frohlich, S., Ryan, T., Fagan, C., Statin therapy associated with fatal rhabdomyolysis, Journal of the Intensive Care Society, 12, (1), 2011, p40-42
McKenny, M., Ryan, T., Tate, H., Graham, B., Young, V.K., Dowd, N., Age of transfused blood is not associated with increased postoperative adverse outcome after cardiac surgery, British Journal of Anaesthesia, 106, (5), 2011, p643-649
Mahabeleshwar, G., Kawanami, D., Sharma, N., Takami, Y., Zhou, G., Shi, H., Nayak, L., Jeyaraj, D., Grealy, R., White, M., McManus, R., Ryan, T., Leahy, P., Lin, Z., Haldar, S., Atkins, G., Wong, H., Lingrel, J., Jain, M., The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock, Immunity, 34, (5), 2011, p715-728
White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158
White M, Lawless MW, O'Dwyer MJ, Grealy R, O'Connell B, Stordeur P, Kelleher D, McManus R*, Ryan T*, Transforming Growth Factor beta-1 and Interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection, Cytokine, 50, 2010, p322 - 327
O'Connor, G. Ryan, T. Redmond, J. Doherty, C., The value of motor response versus neuroimaging in predicting outcome post cardiac arrest: A retrospective study, Journal of Neurology, 257, (8), 2010, p1400 - 1401
Patel KD, Murphy RT, White M, Gasparrow D, Kelleher DP, Ryan T, McManus R, Ryan AW., Interleukin 17: an unlikely marker of acute coronary syndrome?, Atherosclerosis, 205, (1), 2009, p33 - 34
Ryan, A.W., Hughes, D.A., Tang, K., Kelleher, D.P., Ryan, T., McManus, R., Stoneking, M., Natural selection and the molecular basis of electrophoretic variation at the coagulation F13B locus, European Journal of Human Genetics, 17, (2), 2009, p219-227
O'Dwyer, M.J., Mankan, A.K., Ryan, A.W., Lawless, M.W., Stordeur, P., Kelleher, D., McManus, R., Ryan, T., Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis, International Journal of Immunogenetics, 35, (4-5), 2008, p279-285
O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T* , Variability in IL-23 and IL-27 gene expression may determine patient response to a septic insult, Intensive Care Medicine, 34, (4), 2008, p683 - 691
White M, Mankan A, Lawless MW, O'Dwyer MJ, McManus R, Ryan T, Mortality in humans with pneumonia and sepsis is related to an uncompensated anti-inflammatory response to infection, Archives of Internal Medicine, 168, (13), 2008, p1468 - 1469
O'Dwyer MJ, Mankan AK, Stordeur P, White W, Lawless MW, O'Connell B, Kelleher D, McManus R*, Ryan T*. , The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression, Intensive Care Medicine, 34, (4), 2008, p683-691
Duggan, E., Ryan, T., Coagulopathy after cardiac surgery [18], Anesthesia and Analgesia, 105, (5), 2007, p1514-1515
Rowan, M., Ryan, T., Hegarty, F., O'Hare, N., The use of artificial neural networks to stratify the length of stay of cardiac patients based on preoperative and initial postoperative factors, Artificial Intelligence in Medicine, 40, (3), 2007, p211-221
Duggan E, O'Dwyer M, Caraher E, Diviney D, McGovern E, Kelleher D, McManus R, Ryan T, Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism, Anesthesia & Analgesia , 104, (6), 2007, p1343 - 1347
O'Dwyer MJ, Dempsey F, Crowley V, Kelleher D, McManus R, Ryan T., Septic shock correlates with ADMA levels which may be influenced by a polymorphism in DDAH II: a prospective observational study, Critical Care, 10, (5), 2006, pR139 article number
O'Dwyer MJ, Mankan AK, Stordeur P, O'Connell B, Duggan E, White M, Kelleher DP, McManus R, Ryan T., The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression., Shock, 26, (6), 2006, p544 - 550
Ryan R*, Thornton J*, Duggan E, McGovern E, O'Dwyer MJ, Ryan AW, Kelleher D, McManus R, Ryan T, Gene polymorphism and requirement for vasopressor infusion after cardiac surgery, Annals of Thoracic Surgery, 82, (3), 2006, p895 - 901
Duggan, E., Caraher, E., Gately, K., O'Dwyer, M., McGovern, E., Kelleher, D., McManus, R., Ryan, T., Tumor necrosis factor-" and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery, Critical Care Medicine, 34, (8), 2006, p2134-2139
O'Dwyer, M.J., Duggan, E., Ryan, T., Letter regarding article by Tomic et al, "transcriptomic and proteomic patterns of systemic inflammation in on-pump and off-pump coronary artery bypass grafting" [1], Circulation, 113, (19), 2006
O'Dwyer MJ, Mankan AK, Stordeur P, O'Connell B, Duggan E, White M, Kelleher DP, McManus R, Ryan T, The occurrence of severe sepsis is related to distinct patterns of cytokine gene expression, Shock, 26, (6), 2006, p544 - 550
O'Dwyer MJ, Dempsey F, Crowley V, Kelleher DP, McManus R, Ryan T., Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study., Critical Care, 10, (5), 2006, pR139
Eleanor Molloy, Michelle Walsh, Response, J Perinatol, 25, (5), 2005, p360--360
Hodgson A, Ryan T, Moriarty J, Mellotte G, Murphy C, Smith OP, Plasma exchange as a source of protein C for acute onset protein C pathway failure, Br J Haematol., 116, (4), 2002, p905 - 908
T. Ryan, J. Balding, E. M. McGovern, J. Hinchion, W. Livingstone, Z. Chughtai and O. P. Smith, Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes, The Annals of thoracic surgery, 73, (6), 2002, p1905-9; discussion 1910-1
Bashour, C.A., Yared, J.-P., Ryan, T.A., Rady, M.Y., Mascha, E., Leventhal, M.J., Starr, N.J., Long-term survival and functional capacity in cardiac surgery patients after prolonged intensive care, Critical Care Medicine, 28, (12), 2000, p3847-3853
J. McGinley, D. J. McCabe, A. Fraser, E. Casey, T. Ryan and R. Murphy, Hashimoto's encephalopathy; an unusual cause of status epilepticus, Irish medical journal, 93, (4), 2000, p118
Rady, M.Y., Ryan, T., Perioperative predictors of extubation failure and the effect on clinical outcome after cardiac surgery, Critical Care Medicine, 27, (2), 1999, p340-347
Rady, M.Y., Kodavatiganti, R., Ryan, T., Perioperative predictors of acute cholecystitis after cardiovascular surgery, Chest, 114, (1), 1998, p76-84
Barie, P.S., Hydo, L., Ryan, T., Rady, M.Y., Scoring organ dysfunction [1] (multiple letters), Chest, 114, (3), 1998, p941-942
Rady, M.Y., Ryan, T., The effects of preoperative therapy with angiotensin-converting enzyme inhibitors on clinical outcome after cardiovascular surgery, Chest, 114, (2), 1998, p487-494
Rady, M.Y., Kodavatiganti, R., Ryan, T., Perioperative predictors of acute acalculous cholecystitis after cardiac surgery, Critical Care Medicine, 26, (1 SUPPL.), 1998
Rady, M.Y., Ryan, T., Erratum: The effects of preoperative therapy with angiotensin-converting enzyme inhibitors on clinical outcome after cardiovascular surgery (Chest (1998) 114 (487-794)), Chest, 114, (4), 1998
Rady, M.Y., Ryan, T., Starr, N.J., Perioperative determinants of morbidity and mortality in elderly patients undergoing cardiac surgery, Critical Care Medicine, 26, (2), 1998, p225-235
Gordon, S.M., Serkey, J.M., Keys, T.F., Ryan, T., Fatica, C.A., Schmitt, S.K., Borsh, J.A., Cosgrove III, D.M., Yared, J.-P., Secular trends in nosocomial bloodstream infections in a 55-bed cardiothoracic intensive care unit, Annals of Thoracic Surgery, 65, (1), 1998, p95-100
Ryan, T.A., Rady, M.Y., Bashour, C.A., Leventhal, M., Lytle, B., Starr, N.J., Predictors of outcome in cardiac surgical patients with prolonged intensive care stay, Chest, 112, (4), 1997, p1035-1042
Rady, M.Y., Ryan, T., Starr, N.J., Clinical characteristics of preoperative hypoalbuminemia predict outcome of cardiovascular surgery, Journal of Parenteral and Enteral Nutrition, 21, (2), 1997, p81-90
Rady, M.Y., Ryan, T., Starr, N.J., Early onset of acute pulmonary dysfunction after cardiovascular surgery: Risk factors and clinical outcome, Critical Care Medicine, 25, (11), 1997, p1831-1839
Rady, M.Y., Ryan, T., Starr, N.J., Preoperative therapy with amiodarone and the incidence of acute organ dysfunction after cardiac surgery, Anesthesia and Analgesia, 85, (3), 1997, p489-497
Ryan, T., Mc Carthy, J.F., Rady, M.Y., Serkey, J., Gordon, S., Starr, N.J., Cosgrove, D.M., Early bloodstream infection after cardiopulmonary bypass: Frequency rate, risk factors, and implications, Critical Care Medicine, 25, (12), 1997, p2009-2014
Ryan, T., Burwash, I., Lu, J., Otto, C., Graham, M., Verrier, E., Spiess, B.D., The agreement between ventricular volumes and ejection fraction by transesophageal echocardiography or a combined radionuclear and thermodilution technique in patients after coronary artery surgery, Journal of Cardiothoracic and Vascular Anesthesia, 10, (3), 1996, p323-328
Higgins, T.L., Yared, J.-P., Ryan, T., Immediate postoperative care of cardiac surgical patients, Journal of Cardiothoracic and Vascular Anesthesia, 10, (5), 1996, p643-658
Ryan, T., Mannion, D., O'Brien, W., Grace, P., Bouchier-Hayes, D., Cunningham, A.J., Spinal cord perfusion pressure in dogs after control of proximal aortic hypertension during thoracic aortic cross-clamping with esmolol or sodium nitroprusside, Anesthesiology, 78, (2), 1993, p317-325
Ryan, T., Timoney, A., Cunningham, A.J., Use of transoesophageal echocardiography to manage beta-adrenoceptor block and assess left ventricular function in a patient with phaeochromocytoma, British Journal of Anaesthesia, 70, (1), 1993, p101-103
Ryan, T., Page, R., Bouchier-Hayes, D., Cunningham, A.J., Transoesophageal pulsed wave Doppler measurement of cardiac output during major vascular surgery: Comparison with the thermodilution technique, British Journal of Anaesthesia, 69, (1), 1992, p101-104