Peter Owen
Fellow Emeritus, Fellows Emeritii

Biography

Prof. Peter Owen graduated in Chemistry (1st Class) at Univ. Glasgow in 1968 and received Ph.D. in Microbiology from the same institution in 1972. This was followed by a four-year's postdoctorate at Dept. Microbiology, New York University Medical Center with Prof. Milton Salton studying structure and functional aspects of bacterial membranes. During that period he progressed from NATO Postdoctoral Fellow, to Assistant Research Scientist to Assistant Professor and was in part responsible for pioneering the use of 2-D immunoelectrophoretic techniques (crossed immunoelectrophoresis) to the analysis of bacterial membranes and to a study of their molecular architecture. In 1976 he obtained a lecturing position in the Dept. Microbiology, Trinity College Dublin and was subsequently promoted to Fellow of Trinity College (1980) and then to Associate Professor (1986-date). During this period he has maintained a research interest in the general area of bacterial surfaces, focusing on the structure of their membranes and the structure, function, vaccinogenic potential and role in virulence of selected surface components. Arguably some of the more significant contributions during this period include (i) establishing the molecular architecture of membrane vesicles from E. coli (Kabackosomes); (ii) biochemical and biophysical analyses of succinate dehydrogenases from E. coli and M. luteus; (iii) identification and analysis of a novel phase-variable outer membrane protein (antigen 43; Ag43) in E. coli; (iv) analysis and development of a human polyvalent vaccine against Pseudomonas aeruginosa; and (v) establishing the vaccinogenic potential, ligand-binding properties and role in virulence of a major protein (FgBP) present in the cell wall of the organism (Streptococcus equi) which causes equine strangles. Current research activities focus on characterization of haem uptake systems in S. equi and S. zooepidemicus. In 1990 Prof Owen received the Royal Irish Academy National Committee for Biochemistry Award Medal for Outstanding Biochemical Research in Ireland. He is married with two children.

Publications and Further Research Outputs

Peer-Reviewed Publications

Mary Meehan, Melanie J. Lewis, Caroline Byrne, David O'Hare, Jenny M. Woof and Peter Owen, Localization of the equine IgG-binding domain in the fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi, Microbiology, 155, (8), 2009, p2583 - 2592 Journal Article, 2009

das Gracas de Luna, M., A. Scott-Tucker, M. Desvaux, P. Ferguson, N. P. Morin, E. G. Dudley, S. Turner, J. P. Nataro, P. Owen, and I. R. Henderson, The Escherichia coli biofilm-producing protein Antigen 43 does not contribute to intestinal colonization, FEMS Microbiology Letters, 284, 2008, p237 - 246 Journal Article, 2008

Davidson, A., J. L. Traub-Dargatz, R. Magnuson, A. Hill, V. Irwin, R. Newton, A. Waller, K. Smith, R. J. Callan, M. Meehan, P. Owen, and M. Salman, Lack of correlation between antibody titers to fibrinogen-binding protein of Streptococcus equi and persistent carriers of strangles, Journal of Veterinary and Diagnostic Investigation, 20, 2008, p457 - 462 Journal Article, 2008

Lewis, M. J., M. Meehan, P. Owen, and J. M. Woof, A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system, Journal of Biological Chemistry, 283, (25), 2008, p17615 - 17623 Journal Article, 2008 TARA - Full Text DOI

Meehan, M., S. M. Kelly, N. C. Price, and P. Owen, The C-terminal portion of the fibrinogen-binding protein of Streptococcus equi subsp. equi contains extensive alpha-helical coiled-coil structure and contributes to thermal stability, FEMS Microbiology Letters, 206, (1), 2002, p81 - 86 Journal Article, 2002 URL

Waldron, D. E., P. Owen, and C. J. Dorman, Competitive interaction of the OxyR DNA-binding protein and the Dam methylase at the antigen 43 gene regulatory region in Escherichia coli, Molecular Microbiology, 44, (2), 2002, p509 - 520 Journal Article, 2002

Meehan, M., Y. Lynagh, C. Woods, and P. Owen, The fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi additionally binds IgG and contributes to virulence in a mouse model, Microbiology, 147, (12), 2001, p3311 - 3322 Journal Article, 2001 URL

Roche, A. J., J. P. McFadden, and P. Owen, Antigen 43, the major phase-variable protein of the Escherichia coli outer membrane, can exist as a family of proteins encoded by multiple alleles, Microbiology, 147, (1), 2001, p161 - 169 Journal Article, 2001 URL

Meehan, M., D. A. Muldowney, N. J. Watkins, and P. Owen, Localization and characterization of the ligand-binding domain of the fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi, Microbiology, 146, (1), 2000, p1187 - 1194 Journal Article, 2000

Meehan, M., D. A. Muldowney, F. O'Meara, and P. Owen, Neither the A- nor B-repeat regions of the fibrinogen-binding protein of Streptococcus equi subsp. equi are essential for fibrinogen binding, FEMS Microbiology Letters, 190, (2), 2000, p317 - 321 Journal Article, 2000

Henderson, I. R., and P. Owen, The major phase-variable outer membrane protein of Escherichia coli structurally resembles the immunoglobulin A1 protease class of exported protein and is regulated by a novel mechanism involving Dam and OxyR, Journal of Bacteriology, 181, (7), 1999, p2132 - 2141 Journal Article, 1999

Henderson, I. R., P. Owen, and J. P. Nataro, Molecular switches - the ON and OFF of bacterial phase variation, Molecular Microbiology, 33, (5), 1999, p919 - 932 Journal Article, 1999

Meehan, M., P. Nowlan, and P. Owen, Affinity purification and characterization of a fibrinogen-binding protein complex which protects mice against lethal challenge with Streptococcus equi subsp. equi, Microbiology, 144, (4), 1998, p993 - 1003 Journal Article, 1998

Henderson, I. R., M. Meehan, and P. Owen, Antigen 43, a phase variable bipartite outer membrane protein, determines colony morphology and autoaggregation in Escherichia coli K-12, FEMS Microbiology Letters, 149, (1), 1997, p115 - 120 Journal Article, 1997

Henderson, I. R., M. Meehan, and P. Owen, A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli, Advances in Experimental Medicine and Biology, 412, 1997, p349 - 355 Journal Article, 1997

Henderson, I., and P. Owen, The autoregulatory protein Mor and OxyR are identical, Microbiology, 143, (5), 1997, p1482- Journal Article, 1997

Owen, P., M. Meehan, H. de Loughry-Doherty, and I. Henderson, Phase-variable outer membrane proteins in Escherichia coli, FEMS Immunology and Medical Microbiology, 16, (2), 1996, p63 - 76 Journal Article, 1996

Owen, P., The Gram-negative outer membrane: structure, biochemistry and vaccine potential, Biochemical Society Transactions, 20, 1992, p1 - 6 Journal Article, 1992

Knights, J. M., C. Adlam, and P. Owen, Characterization of envelope proteins from Pasteurella haemolytica and Pasteurella multocida, Journal of General Microbiology, 136, (3), 1990, p495 - 505 Journal Article, 1990

Caffrey, P., and P. Owen, Purification and N-terminal sequence of the alpha-subunit of antigen 43, a unique protein complex associated with the outer membrane of Escherichia coli, Journal of Bacteriology, 171, (7), 1989, p3634 - 3640 Journal Article, 1989

Owen, P., P. Caffrey, and L.-G. Josefsson, Identification and partial characterization of a novel bipartite protein antigen associated with the outer membrane of Escherichia coli, Journal of Bacteriology, 169, (8), 1987, p3770 - 3777 Journal Article, 1987

MacIntyre, S., R. Lucken, and P. Owen, Smooth lipopolysaccharide is the major protective antigen for mice in the surface extract from IATS serotype 6 contributing to the polyvalent Pseudomonas aeruginosa vaccine PEV, Infection and Immunity, 52, (1), 1986, p76 - 84 Journal Article, 1986

Doherty, H., H. Yamada, P. Caffrey, and P. Owen, Identification, immunochemical characterization and purification of a major lipoprotein antigen associated with the inner (cytoplasmic) membrane of Escherichia coli, Journal of Bacteriology, 166, (3), 1986, p1072 - 1082 Journal Article, 1986

MacIntyre, S., T. McVeigh, and P. Owen, Immunochemical and biochemical analysis of the polyvalent Pseudomonas aeruginosa vaccine PEV, Infection and Immunity, 51, (2), 1986, p675 - 686 Journal Article, 1986

Owen, P., An improved procedure for polypeptide analysis of radiolabeled antigens resolved by crossed immunoelectrophoresis and its application to the study of inner and outer membranes of Escherichia coli, Electrophoresis, 7, (1), 1986, p19 - 28 Journal Article, 1986

Condon, C., R. Cammack, D. S. Patil, and P. Owen, The succinate dehydrogenase of Escherichia coli: Immunochemical resolution and biophysical characterization of a 4-subunit enzyme complex, Journal of Biological Chemistry, 260, (16), 1985, p9427 - 9434 Journal Article, 1985

Crowe, B. A. and P. Owen, Molecular properties of succinate dehydrogenase isolated from Micrococcus luteus (lysodeikticus), Journal of Bacteriology, 153, (3), 1983, p1493 - 1501 Journal Article, 1983

Bacterial antigens in, Wilson, G., and H. M. Dick , Topley and Wilson's principles of bacteriology, virology and immunity, vol. 1, London, UK, Edward Arnold, 1983, pp337 - 373, [Arbuthnott, J. P., P. Owen, and R. J. Russell] Book Chapter, 1983

Crowe, B. A., P. Owen, and R. Cammack, Study of the respiratory chain of Micrococcus luteus (lysodeikticus) by electron-spin-resonance spectroscopy, European Journal of Biochemistry, 137, (1-2), 1983, p185 - 190 Journal Article, 1983

Crowe, B. A., P. Owen, D. S. Patil, and R. Cammack, Characterization of succinate dehydrogenase from Micrococcus luteus (lysodeikticus) by electron-spin-resonance spectroscopy, European Journal of Biochemistry, 137, (1-2), 1983, p191 - 196 Journal Article, 1983

Crowe, B. A., and P. Owen, Immunochemical analysis of respiratory-chain components of Micrococcus luteus (lysodeikticus), Journal of Bacteriology, 153, (1), 1983, p498 - 505 Journal Article, 1983

Doherty, H. C. Condon, and P. Owen, Resolution and in vitro glycosylation of membrane glycoproteins in Micrococcus luteus (lysodeikticus), FEMS Microbiology Letters, 15, 1982, p331 - 336 Journal Article, 1982

Condon, C., and P. Owen, The succinate dehydrogenase of Escherichia coli: resolution as a major membrane-bound immunogen possessing covalently bound flavin, FEMS Microbiology Letters, 14, 1982, p217 - 221 Journal Article, 1982

Owen, P., and C. Condon, The succinate dehydrogenase of Escherichia coli: subunit composition of the Triton X-100-solubilized antigen, FEMS Microbiology Letters, 14, 1982, p223 - 227 Journal Article, 1982

Condon, C., and P. Owen, Succinate dehydrogenase: a major cross-reacting antigen in the Enterobacteriaceae, FEMS Microbiology Letters, 15, 1982, p109 - 113 Journal Article, 1982

Cammack, R., B. Crowe, and P. Owen, Characterization of succinate dehydrogenase from Micrococcus lysodeikticus, Biochemical Society Transactions, 10, 1982, p261 - 262 Journal Article, 1982

Owen, P., H. R. Kaback, and K. A. Graeme-Cook, Identification of antigen 19/27 as dihydrolipoyl dehydrogenase and its probable involvement in ubiquinone-mediated NADH-dependent transport phenomena in membrane vesicles of Escherichia coli, FEMS Microbiology Letters, 7, 1980, p345 - 348 Journal Article, 1980

Owen, P., G. J. Kaczorowski, and H. R. Kaback, Resolution and identification of iron-containing antigens in membrane vesicles from Escherichia coli, Biochemistry, 19, (3), 1980, p596 - 600 Journal Article, 1980

Owen, P., and H. R. Kaback, Immunochemical analysis of membrane vesicles from Escherichia coli, Biochemistry, 18, (8), 1979, p1413 - 1422 Journal Article, 1979

Owen, P., and H. R. Kaback, Antigenic architecture of membrane vesicles from Escherichia coli, Biochemistry, 18, (8), 1979, p1422 - 1426 Journal Article, 1979

Owen, P., and H. Doherty, Immunochemical analysis of Triton X-100-insoluble residues from Micrococcus lysodeikticus membranes, Journal of Bacteriology, 140, (3), 1979, p881 - 887 Journal Article, 1979

Smyth, C. J., J. Siegel, M. R. J. Salton, and P. Owen, Immunochemical analysis of inner and outer membranes of Escherichia coli by crossed immunoelectrophoresis, Journal of Bacteriology, 133, (1), 1978, p306 - 319 Journal Article, 1978

Owen, P., and H. R. Kaback, Molecular structure of membrane vesicles from Escherichia coli, Proceedings of the National Academy of Sciences USA, 75, (7), 1978, p3148 - 3152 Journal Article, 1978

Owen, P., J. D. Oppenheim, M. S. Nachbar, and R. E. Kessler, The use of lectins in the quantitation and analysis of macromolecules by affinoelectrophoresis, Analytical Biochemistry, 80, (2), 1977, p446 - 457 Journal Article, 1977

Oppenhiem, J. D, P. Owen, M. S. Nachbar, K. Colledge, and H. S. Kaplan, Identification and quantitation of solubilized I blood group substance by wheat germ agglutinin using quantitative immunoelectrophoresis, Immunological Communications, 6, (2), 1977, p167 - 181 Journal Article, 1977

Owen, P., and M. R. J. Salton, Membrane asymmetry and expression of cell surface antigens of Micrococcus lysodeikticus established by crossed immunoelectrophoresis, Journal of Bacteriology, 132, (3), 1977, p974 - 985 Journal Article, 1977

Owen, P., and M. R. J. Salton, Antigenic and enzymatic architecture of Micrococcus lysodeikticus membranes established by crossed immunoelectrophoresis, Proceedings of the National Academy of Sciences USA , 72, (9), 1976, p3711 - 3715 Journal Article, 1976

Salton, M. R. J., and P. Owen, Bacterial membrane structure, Annual Reviews of Microbiology, 30, 1976, p451 - 482 Journal Article, 1976

Owen, P., and M. R. J. Salton, Submicrogram quantitation of an acidic polysaccharide by rocket immunoelectrophoresis and rocket affinoelectrophoresis, Analytical Biochemistry, 73, (1), 1976, p20 - 26 Journal Article, 1976

Owen, P., and M. R. J. Salton, Isolation and characterization of a mannan from mesosomal membrane vesicles of Micrococcus lysodeikticus, Biochimica Biophysica Acta , 406, (2), 1975, p214 - 234 Journal Article, 1975

Owen, P., and M. R. J. Salton, Use of the lectin concanavalin A in the preparation of mesosomal membrane fractions from Micrococcus lysodeikticus, Microbios, 13, 1975, p27 - 39 Journal Article, 1975

Owen, P., and M. R. J. Salton, Distribution of enzymes involved in mannan synthesis in plasma membranes and mesosomal vesicles of Micrococcus lysodeikticus, Biochimica Biophysica Acta, 406, (2), 1975, p235 - 247 Journal Article, 1975

Owen, P., and M. R. J. Salton, A succinylated mannan in the membrane system of Micrococcus lysodeikticus, Biochemical and Biophysical Research Communications, 63, (4), 1975, p875 - 880 Journal Article, 1975

Owen, P., and J. H. Freer, Isolation and properties of mesosomal membrane fractions from Micrococcus lysodeikticus, Biochemical Journal, 129, (4), 1972, p907 - 917 Journal Article, 1972

McNiven, A. C., P. Owen, and J. P. Arbuthnott, Multiple forms of staphylococcal alpha-toxin, Journal of Medical Microbiology, 5, (1), 1972, p113 - 122 Journal Article, 1972

Owen, P., The bacterial mesosome, University of Glasgow, 1972 Thesis, 1972

Owen, P., and J. H. Freer, Factors influencing the activity of succinate dehydrogenase in membrane preparations from Micrococcus lysodeikticus, Biochemical Journal, 120, (2), 1970, p237 - 243 Journal Article, 1970

Non-Peer-Reviewed Publications

Meehan, M., D. Muldowney, and P. Owen, Localisation of the ligand-binding domain in the fibrinogen-binding protein from Streptococcus equi, 142nd Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1999, pp62 (P11) Conference Paper, 1999

Roche, A. J., and P. Owen, In contrast to Escherichia coli K12, E. coli ML308-225 possesses two copies of agn43 - the gene encoding a major phase variable outer membrane protein, IUMS International Congress of Bacteriology and Applied Microbiology and Mycology, Sydney, Australia, 1999, pp56 (BP01.07) Conference Paper, 1999

Roche, A. J., and P. Owen, Some Escherichia coli strains possess multiple copies of agn43 - the gene encoding a major phase variable outer membrane protein, 142nd Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1999, pp63 (P14) Conference Paper, 1999

Meehan, M., P. Nowlan, and P. Owen, Characterisation of a protective, fibrinogen-binding protein from Streptococcus equi, Irish Branch Symposium for the Society for General Microbiology, Dublin, Ireland, 1998, pp13 Conference Paper, 1998

Meehan, M., P. Nowlan, and P. Owen, A protective fibrinogen-binding protein of Streptococcus equi, 140th Ordinary Meeting of the Society for General Microbiology, Nottingham, UK, 1998, pp74 (P24) Conference Paper, 1998

Henderson, I. R., and P. Owen, Phase variation of outer membrane proteins in Escherichia coli - evidence for transcriptional regulation by deoxyadenosine methylase and OxyR, 97th General Meeting of the American Society for Microbiology, Miami Beech, Florida, 1997, pp80 (B303) Conference Paper, 1997

Meehan, M and P. Owen, Subunit vaccine for Streptococcus equi, 1997, PCT/IE97/00046 Patent, 1997

Henderson, I., and P. Owen, OxyR - a methylation blocking factor in Escherichia coli, Symposium of the Irish Brach of the Society for General Microbiology, Dublin, Ireland, 1996, pp12 Conference Paper, 1996

Henderson, I., and P. Owen, Cloning and sequencing of the gene encoding a phase-variable outer membrane protein from Escherichia coli, Irish Branch Meeting of the Society for General Microbiology, Galway, Ireland, 1996, pp13 Conference Paper, 1996

Owen, P., M. Meehan, H. Doherty, and I. Henderson, Phase-variable outer-membrane proteins in Escherichia coli, Irish Branch Meeting of the Society for General Microbiology, Galway, Ireland, 1996, pp1-2 Conference Paper, 1996

Henderson, I. R., M. C. Meehan, and P. Owen, A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli, 1st International Rushmore Conference on "Mechanisms in the pathogenesis of enteric diseases" , Rapid City, S. Dakota, 1995, pp31 Conference Paper, 1995

Immunochemistry of bacterial antigens in, van Os, C. J., and M. H. V. van Regenmortel , Immunochemistry, New York, Marcel Dekker, Inc., 1994, pp393 - 453, [Owen, P., and M. Meehan] Book Chapter, 1994

Henderson, I. R., and P. Owen, Dam methylation affects expression of antigen 43 in Escherichia coli, Irish Branch Meeting of the Society for General Microbiology, Jordanstown, N. Ireland, 1994, (P11) Conference Paper, 1994

Henderson, I., M. Meehan, and P. Owen, Proteolytic studies on antigen 43 - a bipartite outer membrane protein of Escherichia coli, 129th Ordinary Meeting of the Society for General Microbiology, Noordwijkerhout, The Netherlands, 1994, pp52 (P50) Conference Paper, 1994

McClean, K., and Owen, P., Characterization of enterocoliticin: a bacteriocin from Yersinia enterocolitica, 123rd Ordinary Meeting of the Society for General Microbiology, Dublin, Ireland, 1992, pp63 (P52) Conference Paper, 1992

Owen, P., Heterooligomeric outer membrane protein antigens, 123rd Ordinary Meeting of the Society for General Microbiology, Dublin, Ireland, 1992, pp30 Conference Paper, 1992

Meehan, M., H. Doherty, and P. Owen, Immunological studies of a bipartite outer membrane protein in Escherichia coli, 123rd Ordinary Meeting of the Society for General Microbiology, Dublin, Ireland, 1992, pp62 (P51) Conference Paper, 1992

McClean, K., and P. Owen, Enterocoliticin: a bacteriocin from Yersinia enterocolitica, 119th Ordinary Meeting of the Society for General Microbiology, Edinburgh, UK, 1991, pp51 (P22) Conference Paper, 1991

Outer membrane proteins: old and new in, Ron, E. Z., and S. Rottem , Microbial surface components and toxins in relation to pathogenesis, New York, Plenum Press, 1991, pp127 - 139, [Owen, P., P. Caffrey, L.-G. Josefsson, and M. Meehan] Book Chapter, 1991

Meehan, M., P. Caffrey, and P. Owen, Phase variation of an outer membrane protein of Escherichia coli, 119th Ordinary Meeting of the Society for General Microbiology, Edinburgh, UK, 1991, pp45 (P8) Conference Paper, 1991

Owen, P., Tumour-directed hybrid protein toxins: a review, Stockholm, Sweden, KabiVitrum AB, 1990 Report, 1990

Owen, P., Bacterial cell membranes: structure, biochemistry and vaccine potential, Biochemistry Award Lecture, Royal Irish Academy, Dublin, 1990, Royal Irish Academy National Committee for Biochemistry, 1 - 80pp Invited Talk, 1990

Owen, P., Outer membrane proteins: their role in virulence, FEMS Workshop on "Microbial surface components and toxins in relation to pathogenesis", Mitzpeh Rachel, Israel, 1989, pp16 Conference Paper, 1989

Owen, P., and T. J. Foster, Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Elsevier Science Publishers B. V., 1988, 1 - 342pp Book, 1988

Crossed immunoelectrophoresis: a literature guide in, Owen, P., and T. J. Foster , Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Owen, P., and T. J. Foster, 1988, pp245 - 254, [Owen, P.] Book Chapter, 1988

Western immunoblotting in, Owen, P., and T. J. Foster , Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Elsevier Science Publishers B. V., 1988, pp255 - 266, [Caffrey, P., T. McVeigh, and P. Owen] Book Chapter, 1988

Owen, P. , Review of Bacterial cell surface techniques, by Hancock, I. C., and I. R. Poxton , Journal of Applied Bacteriology, 1988 Review, 1988

Surface antigens of Pseudomonas aeruginosa: analysis by crossed immunoelectrophoresis and role in protection in, Owen, P., and T. J. Foster , Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Elsevier Science Publishers B. V., 1988, pp133 - 146, [MacIntyre, S., T. McVeigh, and P. Owen] Book Chapter, 1988

Owen, P. , Review of Bacterial cell surface techniques, by Hancock, I. C., and I. R. Poxton , Disease Markers, 1988 Review, 1988

Owen., P., Review of Membrane proteins: structure, function, assembly. Nobel Symposium 66, by Rydstrom, J. , Society for General Microbiology Quarterly, 1988 Review, 1988

Silver staining of proteins and lipopolysaccharides in SDS-polyacrylamide gels in, Owen, P., and T. J. Foster , Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Elsevier Science Publishers B. V., 1988, pp267 - 279, [McVeigh, T., P. Caffrey, and P. Owen] Book Chapter, 1988

Outer membrane proteins: their role in virulence in, Owen, P., and T. J. Foster , Immunochemical and molecular genetic analysis of bacterial pathogens, Amsterdam, Elsevier Science Publishers B. V., 1988, pp27 - 43, [Owen, P.] Book Chapter, 1988

Caffrey, P., and P. Owen, A major new protein antigen in the outer membrane of Escherichia coli, Bacterial cell surfaces in bioscience, Ito, Japan, 1987, pp155 Conference Paper, 1987

Caffrey, P., and P. Owen, A unique protein complex in the outer membrane of Escherichia coli ML308-225, XIV International Congress of Microbiology, Manchester, UK, 1986, pp119 (P.B23-18) Conference Paper, 1986

McVeigh, T., S. MacIntyre, R. Lucken, and P. Owen, Lipopolysaccharide is a major protective antigen in the polyvalent pseudomonas vaccine PEV, Journal of Immunology and Immunopharmacology, Endotoxins: structural aspects and immunobiology of host responses, Riva del Sole, Italy, 6, (Suppl. 3), 1986, pp267 Conference Paper, 1986

Owen, P. , Electroimmunochemical method for the analysis of cell surface antigens, FEMS/SGM Lab. Course on "Immunochemical and molecular genetic analysis of bacterial pathogens and their virulence determinants, Dublin, Ireland, 1986, ppL13 Conference Paper, 1986

Caffrey, P., and P. Owen, Characterization of a novel bipartite protein antigen associated with the outer membrane of Escherichia coli, 86th Annual Meeting of the American Society for Microbiology, Washigton, DC, 1986, pp195 (K10) Conference Paper, 1986

Owen, P., Immunochemical analysis of bacterial envelopes - a Laboratory Manual for FEMS/SGM Workshop, 1986, - C1-C26 Miscellaneous, 1986

Owen, P. , Electroimmunochemical analysis applied to the analysis of Pseudomonas cell surface antigens, FEMS/SGM Lab. Course on "Immunochemical and molecular genetic analysis of bacterial pathogens and their virulence determinants", Dublin, Ireland, 1986, ppL17 Conference Paper, 1986

Owen, P., Review of Current communications in membranes and transport (vol. 23) Genes and membranes: transport proteins and receptors, by Adelberg, E. A., C. W. Slaymen, J. F. Hoffman, and G. Giebrisch , Society for General Microbiology Quarterly, 1985 Review, 1985

Owen, P., Crossed immunoelectrophoresis. Its application to the study of bacterial membranes, Spring Meeting of the British Electrophoresis Society, Bournemouth, UK, 1985, pp4 Conference Paper, 1985

Caffrey, P., and P. Owen, Characterization of a novel bipartite protein antigen in the outer membrane of Escherichia coli, 103rd Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1985, ppM17 (P20) Conference Paper, 1985

McVeigh, T., S. MacIntyre, R. Lucken, and P. Owen, Protective antigens in the polyvalent Pseudomonas vaccine PEV, 103rd Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1985, ppM19 (P33) Conference Paper, 1985

Crossed immunoelectrophoresis in the study of outer membrane antigens in, Korhonen, T. K., E. A. Dawes, and P. H. Makela , Enterobacterial surface antigens: methods for molecular characterisation, Amsterdam, Elsevier Science Publishers B. V., 1985, pp207 - 242, [Owen, P.] Book Chapter, 1985

Doherty, H., H. Yamada, and P. Owen, Characterization of a major lipoprotein antigen in the inner membrane of Escherichia coli, 103rd Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1985, ppM17 (P19) Conference Paper, 1985

Owen, P., Review of Current communications in molecular biology. Protein transport and secretion, by Gething, M.-J. , Society for General Microbiology Quarterly, 1985 Review, 1985

Condon, C., P. Owen, D. S. Patil, and R. Cammack, Immunopurification, biochemical analysis and ESR spectroscopy of succinate dehydrogenase from Escherichia coli, 609th Meeting of the Biochemical Society, Leeds, UK, 1984 Conference Paper, 1984

Cammack, R., D. S. Patil, C. Condon, P. Owen, S. T. Cole, and J. H. Weiner, ESR spectroscopic studies of succinate dehydrogenase and fumarate reductase from Escherichia coli, Flavins and flavoproteins, Brighton, UK, 1984 Conference Paper, 1984

Cammack, R., C. Condon, B. A. Crowe, and P. Owen, Biochemical and biophysical analyses of succinate dehydrogenase from Micrococcus luteus and Escherichia coli, Canadian Biochemical Society Symposium on "Molecular aspects of membrane structure and function", Banff, Alberta, 1984, (T24) Conference Paper, 1984

MacIntyre, S., R. N. Lucken, and P. Owen., Protective antigens of a Pseudomonas aeruginosa vaccine, PEV, Lunteren Lectures in Molecular Genetics, 1984, pp30 Conference Paper, 1984

MacIntyre, S., R. Lucken, J. Beale, and P. Owen, Identification of a major protective component in Pseudomonas aeruginosa vaccine, PEV, 100th Ordinary Meeting of the Society for General Microbiology, Warwick, UK, 1984, ppM20 (P92) Conference Paper, 1984

Owen, P., Crossed immunoelectrophoresis in the study of outer membrane antigens - a FEMS Workshop Laboratory Manual, 1984, - 1-34 Miscellaneous, 1984

Owen, P., Review of Bacterial protein toxins, by Alouf, J. F., F. J. Fehrenbach, J. H. Freer, and J. Jeljaszewicz , Society for General Microbiology Quarterly, 1984 Review, 1984

ESR spectroscopic studies of succinate dehydrogenase and fumarate reductase from Escherichia coli in, Bray, R. C., P. C. Engel, and S. G. Mayhew , Flavins and flavoproteins, Berlin, Walter de Gruyter & Co., 1984, pp551 - 554, [Cammack, R., D. S. Patil, C. Condon, P. Owen, S. T. Cole, and J. H. Weiner] Book Chapter, 1984

Owen, P., Antigenic and biochemical architecture of bacterial membranes, 15th FEBS Meeting, Brussels, 1983, pp25 Conference Paper, 1983

The topological arrangement of proteins in membranes determined by electroimmunochemical methods in, Bjerrum, O. J. , Electroimmunochemical analysis of membrane proteins, Amsterdam, Elsevier Science Publishers, 1983, pp55 - 76, [Owen, P.] Book Chapter, 1983

Antigens of the Escherichia coli cell envelope in, Bjerrum, O. J. , Electroimmunochemical analysis of membrane proteins, Amsterdam, Elsevier Science Publishers, 1983, pp347 - 373, [Owen, P.] Book Chapter, 1983

Crowe, B. A., P. Owen, and R. Cammack, Characterization of the succinate dehydrogenase from Micrococcus lysodeikticus by ESR spectroscopy, Society for General Microbiology Quarterly, 94th Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 9, 1982, (P3) Conference Paper, 1982

Cammack, R., B. Crowe, and P. Owen, Characterization of the succinate dehydrogenase from Micrococcus lysodeikticus, 599th Meeting of the Biochemical Society, 1982 Conference Paper, 1982

Crowe, B. A., and P. Owen, Molecular properties of the succinate dehydrogenase complex from Micrococcus lysodeikticus, Society for General Microbiology Quarterly, 94th Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 9, 1982, (P4) Conference Paper, 1982

Condon, C., J. R. Guest, and P. Owen, The succinate dehydrogenase of Escherichia coli, XIII International Congress of Microbiology, Boston, Mass., 1982, pp126 (P44:6) Conference Paper, 1982

Bacterial membranes: preparative techniques and criteria of purity in, Hesketh, T. R., H. L. Kornberg, J. C. Metcalfe, D. H. Northcote, C. I. Pogson, and K. F. Tipton , Techniques in lipid and membrane biochemistry, pt. 1, vol. B4/1, Shannon, Ireland, Elsevier/North Holland Scientific Publishers Ltd., 1982, ppB407b/1 - B407b/69, [Owen, P., K. A. Graeme-Cook, B. A. Crowe, and C. Condon] Book Chapter, 1982

Immunology of the bacterial membrane in, Ghosh, B. K. , Organization of prokaryotic cell membranes, Vol.1, Boca Raton, Florida, CRC Press, Inc., 1981, pp73 - 164, [Owen, P] Book Chapter, 1981

Doherty, H., C. Condon, and P. Owen, Characterization and biosynthesis of a membrane-bound glycoprotein in Micrococcus lysodeikticus, Society for General Microbiology Quarterly, 91st Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 8, 1981, pp115 (G45) Conference Paper, 1981

Condon, C., and P. Owen, Characterization of succinate dehydrogenase from Escherichia coli, Society for General Microbiology Quarterly, 91st Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 8, 1981, pp116 (G46) Conference Paper, 1981

Owen, P., A novel protein antigen in the outer membrane of Escherichia coli, Society for General Microbiology Quarterly, 91st Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 8, 1981, pp115 (G44) Conference Paper, 1981

Crowe, B. A., and P. Owen, Analysis of iron-containing membrane antigens of Micrococcus lysodeikticus, Society for General Microbiology Quarterly, 88th Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 7, 1980, pp72 (G1) Conference Paper, 1980

Owen, P., Protein-protein interactions in bacterial envelopes investigated by high-resolution immunological procedures, FEMS Symposium on "Microbial envelopes", Saimaanranta, Finland, 1980, pp72 Conference Paper, 1980

Graeme-Cook, K., T. J. Foster, and P. Owen, Tetracycline uptake in Escherichia coli, Society for General Microbiology Quarterly, 85th Ordinary Meeting of the Society for General Microbiology, Cambridge, UK, 6, 1979, pp82 (G28) Conference Paper, 1979

Owen, P., and H. R. Kaback, Resolution and properties of the membrane-bound NADH dehydrogenase of Escherichia coli, Society for General Microbiology Quarterly, 86th Ordinary Meeting of the Society for General Microbiology, Dublin, Ireland, 6, 1979, pp165-166 (G58) Conference Paper, 1979

Owen, P., and H. R. Kaback, Molecular architecture of membrane vesicles from Escherichia coli, 11th International Congress of Biochemistry, Toronto, 1979 Conference Paper, 1979

Owen, P., and H. R. Kaback, Molecular structure of membrane vesicles from E. coli, Frontiers of biological energetics; electrons and tissues , Johnson Foundation (in celebration of 65th birthday of Britton Chance), 1978 Conference Paper, 1978

Owen, P., and H. R. Kaback, The molecular architecture of membrane vesicles from Escherichia coli ML308-225 established by crossed immunoelectrophoresis, Proceedings of the Society for General Microbiology, 82nd Ordinary Meeting of the Society for General Microbiology, Southampton, UK, 5, 1978, pp51-52 (G20) Conference Paper, 1978

Kaback, H. R., and P. Owen, Immunochemical analysis of membrane vesicles from Escherichia coli ML308-225, Proceedings of the Society for General Microbiology, 82nd Ordinary Meeting of the Society for General Microbiology, Southampton, UK, 5, 1978, pp51 (G19) Conference Paper, 1978

Enzyme analysis by quantitative immunoelectrophoresis in, Salton, M. R. J. , Immunochemistry of enzymes and their antibodies, New York, John Wiley and Sons, Inc, 1977, pp147 - 202, [Owen, P., and C. J. Smyth] Book Chapter, 1977

Smyth, C. J., P. Owen, and M. R. J. Salton, Immunochemical analysis of inner and outer membranes of E. coli K12 using crossed immunoelectrophoresis, 8th Meeting of the North West European Microbiology Group, Helsinki, 1976, pp156 Conference Paper, 1976

Smyth, C. J., and P. Owen, The architecture of E. coli membranes established by crossed immunoelectrophoresis, Pan American Society Biochemical Society Symposium on "Structure and function of biological membranes", Banff, Alberta, 1976 Conference Paper, 1976

Owen, P., and M. R. J. Salton, Some properties of a mannan isolated from the mesosome of Micrococcus lysodeikticus, 75th Annual Meeting of the American Society for Microbiology, 1975, ppK127 Conference Paper, 1975

Owen, P., and M. R. J. Salton, Membrane architecture established by crossed immunoelectrophoresis, Proceedings of the Society for General Microbiology, 75th Ordinary Meeting of the Society for General Microbiology, Reading, UK, 3, 1975, pp61 Conference Paper, 1975

Owen, P., Review of Immunoelectrophoresis: theory, methods, identification, interpretation, by Arquembourg, P. C. , American Society for Microbiology News, 1975 Review, 1975

Smyth, C. J., and P. Owen, Review of Quantitative immunoelectrophoresis: new developments and applications, by Axelsen, N. N. , American Society for Microbiology News, 1975 Review, 1975

Owen, P., and M. R. J. Salton, Mannose-polymers in the membrane fractions isolated from Micrococcus lysodeikticus, 74th Annual Meeting of the American Society for Microbiology, 1974, ppP80 Conference Paper, 1974

Freer J. H., and P. Owen, P., Mesosomal membranes of Micrococcus lysodeikticus, 4th International Congress of Bacteriology, Jerusalem, 1973, pp1 - 1 Conference Paper, 1973

Owen, P., and J. H. Freer, Factors influencing the activity of succinate dehydrogenase in membrane preparations from Micrococcus lysodeikticus, Journal of General Microbiology, 57th Ordinary Meeting of the Society for General Microbiology, Norwich, UK, 1970, 60, 1970, ppxi - xii Conference Paper, 1970

Owen, P., FEMS/SGM Laboratory Course: Immunological and Molecular Genetic Analysis of Bacterial Pathogens and their Virulence Determinants, 1986, Trinity College Dublin, Elsevier Science Publishers B. V.,1988, FEMS Symposium No 40, 1-342 Meetings /Conferences Organised,

Research Expertise

Description

Current Research Interests include the following: (a) Investigation of the iron/haem uptake in the veterinary pathogens Streptococcus equi subspecies equi and Streptococcus equi subspecies zooepidemicus with emphasis on the role of haem uptake in virulence and the molecular characterization and protective potential of the various haem uptake components. (b) Molecular characterization of the fibrinogen-binding protein of the equine pathogen Streptococcus equi subspecies equi, its ligand-binding properties, role in virulence and vaccinogenic potential. (c) Functional analysis of Antigen 43 (Ag43), a major phase-variable surface antigen of enteropathogenic Escherichia coli.

Keywords

Infectious Diseases/Agents; Membrane Structure/Function; Molecular Biology; Proteins and Macromolecules; Structural Biology, Determination, Function; Vaccines

Recognition

Awards and Honours

Fellow of Trinity College Dublin 1980

Royal Irish Academy Biochemistry Award Medal for Outstanding Biochemical Research In Ireland 1990

Memberships

American Society for Microbiology (ASM) 1975 – 2005

Society for General Microbiology (SGM) 1973 – 2005