Dr. Pierce Kavanagh
Chief Technical Officer 1, Pharmacology & Therapeutics
Publications and Further Research Outputs
Peer-Reviewed Publications
Kavanagh PV, Power JD, New psychoactive substances legislation in Ireland - Perspectives from academia., Drug testing and analysis, 6, (7-8), 2014, p884-91
Scott KR, Power JD, McDermott SD, O'Brien JE, Talbot BN, Barry MG, Kavanagh PV, Identification of (2-aminopropyl)indole positional isomers in forensic samples., Drug testing and analysis, 6, (7-8), 2014, p598-606
Brandt SD, Baumann MH, Partilla JS, Kavanagh PV, Power JD, Talbot B, Twamley B, Mahony O, O'Brien J, Elliott SP, Archer RP, Patrick J, Singh K, Dempster NM, Cosbey SH, Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni')., Drug testing and analysis, 6, (7-8), 2014, p684-95
Power JD, Barry MG, Scott KR, Kavanagh PV, An unusual presentation of a customs importation seizure containing amphetamine, possibly synthesized by the APAAN-P2P-Leuckart route., Forensic science international, 234, 2014, pe10-3
Bouso ED, Gardner EA, O'Brien JE, Talbot B, Kavanagh PV, Characterization of the pyrolysis products of methiopropamine., Drug testing and analysis, 6, (7-8), 2014, p676-83
Power JD, O'Brien J, Talbot B, Barry M, Kavanagh P, The identification of an impurity product, 4,6-dimethyl-3,5-diphenylpyridin-2-one in an amphetamine importation seizure, a potential route specific by-product for amphetamine synthesized by the APAAN to P2P, Leuckart route., Forensic science international, 241, 2014, pe13-9
Power JD, Scott KR, Gardner EA, Curran McAteer BM, O'Brien JE, Brehon M, Talbot B, Kavanagh PV, The syntheses, characterization and in vitro metabolism of nitracaine, methoxypiperamide and mephtetramine., Drug testing and analysis, 6, (7-8), 2014, p668-75
Christie R, Horan E, Fox J, O'Donnell C, Byrne HJ, McDermott S, Power J, Kavanagh P, Discrimination of cathinone regioisomers, sold as 'legal highs', by Raman spectroscopy., Drug testing and analysis, 6, (7-8), 2014, p651-7
Welter J, Kavanagh P, Maurer HH, GC-MS and LC-(high-resolution)-MS(n) studies on the metabolic fate and detectability of camfetamine in rat urine., Analytical and bioanalytical chemistry, 406, (16), 2014, p3815-29
Power JD, Kavanagh P, O'Brien J, Barry M, Twamley B, Talbot B, Dowling G, Brandt SD, Test purchase, identification and synthesis of 2-amino-1-(4-bromo-2, 5-dimethoxyphenyl)ethan-1-one (bk-2C-B)., Drug testing and analysis, 2014
Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM, Brandt SD, Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers., Drug testing and analysis, 2014
Welter J, Meyer MR, Kavanagh P, Maurer HH, Studies on the metabolism and the detectability of 4-methyl-amphetamine and its isomers 2-methyl-amphetamine and 3-methyl-amphetamine in rat urine using GC-MS and LC-(high-resolution)-MSn., Analytical and bioanalytical chemistry, 406, (7), 2014, p1957-74
Kavanagh P, O'Brien J, Power JD, Talbot B, McDermott SD, 'Smoking' mephedrone: the identification of the pyrolysis products of 4-methylmethcathinone hydrochloride., Drug testing and analysis, 5, (5), 2013, p291-305
Grigoryev A, Kavanagh P, Melnik A, The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography - mass spectrometry., Drug testing and analysis, 5, (2), 2013, p110-5
Malone ME, Corrigan OI, Kavanagh PV, Gowing C, Donnelly M, D'Arcy DM, Pharmacokinetics of amphotericin B lipid complex in critically ill patients undergoing continuous venovenous haemodiafiltration., International journal of antimicrobial agents, 42, (4), 2013, p335-42
Kavanagh P, Grigoryev A, Savchuk S, Mikhura I, Formanovsky A, UR-144 in products sold via the Internet: identification of related compounds and characterization of pyrolysis products., Drug testing and analysis, 5, (8), 2013, p683-92
Angelov D, O'Brien J, Kavanagh P, The syntheses of 1-(2-thienyl)-2-(methylamino) propane (methiopropamine) and its 3-thienyl isomer for use as reference standards., Drug testing and analysis, 5, (3), 2013, p145-9
Grigoryev A, Kavanagh P, Melnik A, Savchuk S, Simonov A, Gas and liquid chromatography-mass spectrometry detection of the urinary metabolites of UR-144 and its major pyrolysis product., Journal of analytical toxicology, 37, (5), 2013, p265-76
Kavanagh P, Grigoryev A, Melnik A, Savchuk S, Simonov A, Rozhanets V, Detection and tentative identification of urinary phase I metabolites of phenylacetylindole cannabimimetics JWH-203 and JWH-251, by GC-MS and LC-MS/MS., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 934, 2013, p102-8
Dossou KS, Devkota KP, Kavanagh PV, Beutler JA, Egan JM, Moaddel R, Development and preliminary validation of a plate-based CB1/CB2 receptor functional assay., Analytical biochemistry, 437, (2), 2013, p138-43
Power JD, Clarke K, McDermott SD, McGlynn P, Barry M, White C, O'Brien J, Kavanagh P, The identification of 4-methylamphetamine and its synthesis by-products in forensic samples., Forensic science international, 228, (1-3), 2013, p115-31
Welter J, Meyer MR, Wolf EU, Weinmann W, Kavanagh P, Maurer HH, 2-methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques., Analytical and bioanalytical chemistry, 405, (10), 2013, p3125-35
Stanczuk A, Morris N, Gardner EA, Kavanagh P, Identification of (2-aminopropyl)benzofuran (APB) phenyl ring positional isomers in internet purchased products., Drug testing and analysis, 5, (4), 2013, p270-6
Kavanagh P, Angelov D, O'Brien J, Power JD, McDermott SD, Talbot B, Fox J, O'Donnell C, Christie R, The synthesis and characterization N-methyl-3-phenyl-norbornan-2-amine (Camfetamine")., Drug testing and analysis, 5, (4), 2013, p247-53
Kavanagh P, Grigoryev A, Melnik A, Simonov A, The identification of the urinary metabolites of 3-(4-methoxybenzoyl)-1-pentylindole (RCS-4), a novel cannabimimetic, by gas chromatography-mass spectrometry., Journal of analytical toxicology, 36, (5), 2012, p303-11
Kavanagh P, O'Brien J, Fox J, O'Donnell C, Christie R, Power JD, McDermott SD, The analysis of substituted cathinones. Part 3. Synthesis and characterisation of 2,3-methylenedioxy substituted cathinones., Forensic science international, 216, (1-3), 2012, p19-28
Power JD, McDermott SD, Talbot B, O'Brien JE, Kavanagh P, The analysis of amphetamine-like cathinone derivatives using positive electrospray ionization with in-source collision-induced dissociation., Rapid communications in mass spectrometry : RCM, 26, (22), 2012, p2601-11
Kavanagh P, Angelov D, O'Brien J, Fox J, O'Donnell C, Christie R, Power JD, McDermott SD, The syntheses and characterization 3ß-(4-fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3" isomer., Drug testing and analysis, 4, (1), 2012, p33-8
Grigoryev A, Kavanagh P, Melnik A, The detection of the urinary metabolites of 3-[(adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a novel cannabimimetic, by gas chromatography-mass spectrometry., Drug testing and analysis, 4, (6), 2012, p519-24
McDermott SD, Power JD, Kavanagh P, O'Brien J, The analysis of substituted cathinones. Part 2: an investigation into the phenylacetone based isomers of 4-methylmethcathinone and N-ethylcathinone., Forensic science international, 212, (1-3), 2011, p13-21
Power JD, McGlynn P, Clarke K, McDermott SD, Kavanagh P, O'Brien J, The analysis of substituted cathinones. Part 1: chemical analysis of 2 - 3- and 4-methylmethcathinone., Forensic science international, 212, (1-3), 2011, p6-12
Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031
Al Sharef, O.; Feely, J.; Kavanagh, P. V.; Scott, K. R.; Sharma, S. C. , An HPLC method for the determination of the free cortisol/cortisone ratio in human urine. , Biomedical Chromatography , 21, (11), 2007, p1201 - 1206
Douglas, Ruth H.; Muldowney, Ciaran A.; Mohamed, Rabab; Keohane, Fiona; Shanahan, Catherine; Walsh, John J.; Kavanagh, Pierce V., Detection and quantification of valerenic acid in commercially available valerian products. , Journal of Chemical Education, 84, (5), 2007, p829 - 831
Al Sharef O, Feely J, Kavanagh PV, Scott KR, Sharma SC, An HPLC method for the determination of the free cortisol/cortisone ratio in humans, Biomedical Chromatography, 21, (11), 2007, p1201 - 1206
Doyle, Andrea M.; Reilly, Joe: Murphy, Niamh; Kavanagh, Pierce V.; O'Brien, John E.; Walsh, Martin, S.; Walsh, John J., Nature's sedative: Isolation and structural elucidation of valtrate from Centranthus ruber, Journal of Chemical Education, 81, (10), 2004, p1486 - 1487
Hennessy, M.; Kelleher, D.; Spiers, J. P.; Barry, M.; Kavanagh, P.; Back, D.; Mulcahy, F.; Feely, J., St John's Wort increases expression of P-glycoprotein: Implications for drug interactions, British Journal of Clinical Pharmacology, 53, (1), 2002, p75 - 82
Kavanagh, P.; Dunne, J.; Feely, J.; Maguire, R.; Corrigan, D.; Keating, J. J.; Meegan, M. J.; Clancy, J. M.; Burdett, J., Phenylalkylamine abuse among opiate addicts attending a methadone treatment programme in the Republic of Ireland, Addiction Biology, 6, (2), 2001, p177 - 181
Walshe, K.; Barrett, A. M.; Kavanagh, P. V.; McNamara, S. M.; Moran, C.; Shattock, A. G., A sensitive immunoassay for flunitrazepam and metabolites, Journal of Analytical Toxicology, 24, (4), 2000, p296 - 299
Kavanagh, P. V.; Corrigan, D.; Maguire, R. T.; Meegan, M. J.; Keating, J. J.; Clancy, J.; Burdett, J., Excretion profile of 4-methylthioamphetamine in dogs, Pharmacy and Pharmacology Communications, 5, (11), 1999, p653 - 655
Feely, J.; Kavanagh, P. V.; McNamara, S. M.; O'Brien, J. E., Simple preparation of the major urinary metabolites of flunitrazepam and nitrazepam, Irish Journal of Medical Science, 168, (1), 1999, p8 - 9
Barrett, A. M.; Walshe, K.; Kavanagh, P. V.; McNamara, S. M.; Moran, C.; Burdett, J.; Shattock, A. G., A comparison of five commercial immunoassays for the detection of flunitrazepam and other benzodiazepines in urine, Addiction Biology, 4, (1), 1999, p81 - 87
Feely, J.; Kavanagh, P. V.; McNamara, S. M., The detection and quantitation of 7-aminoflunitrazepam, the major urinary metabolite of flunitrazepam, by gas chromatography/mass spectrometry, Irish Journal of Medical Science, 168, (3), 1999, p189 - 192
lkatheeri, Nawal A.; Wasfi, I. A.; Kavanagh, P.; Lambert, M., Identification and confirmation of 3-hydroxy metabolite of ketoprofen in camels by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy, Journal of Chromatography, B: Biomedical Sciences and Applications, 732, (2), 1999, p299 - 306
J. F. Daniel Kelly, Máire E. Doyle, Madhumita Guha, Pierce V. Kavanagh, John M. Kelly and T. Brian H. McMurry, Photochemistry of substituted cyclic enones. Part 11.1 Synthesis and photophysics of 5-arylalkyl-3-phenylcyclopentenones, Journal of the Chemical Society - Perkins Transactions 2, 1998, p1635 - 1641
Kelly, J. F. Daniel; Doyle, Maire E.; Guha, Madhumita; Kavanagh, Pierce V.; Kelly, John M.; McMurry, T. Brian H., Photochemistry of substituted cyclic enones. Part 11. Synthesis and photophysics of 5-arylalkyl-3-phenylcyclopentenones, Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry, 7, 1998, p1635 - 1642
Hook, I.; Walsh, J.; Kavanagh, P.; Reininger, R., Naphthoquinone production by cultures of cape sundew (Drosera capensis), Pharmaceutical and Pharmacological Letters, 7, (2/3), 1997, p93 - 95
C.J. Cardin, P.V. Kavanagh, T.B.H. McMurry and D.J. Wilcock, Synthesis of the tricyclo[6.2.1.03,8] undecan-9-one skeleton, J. Chem. Res., M, 1994, p701
P.V. Kavanagh, J.M. Kelly, T.B.H. McMurry and J.P. James, Intramolecular photocyclisation of molecules containing both 3-phenylcyclopentenone and uracil rings, Chem. Comm., 231, 1993
P.V. Kavanagh, M.B.T. Lambert, B. McKenna and T.B.H. McMurry, Synthesis of possible metabolites of medetomidine {1-(2,3-dimethylphenyl)-1-[imidazol-4(5)-yl]ethane}, J. Chem. Res., M, 1993, p152
C.J. Cardin, M.A. Convery, P.V. Kavanagh, M.B.T. Lambert, B. McKenna and T.B.H. McMurry, Synthesis of 3-[4(5)-imidazolylmethyl]-2-methylbenzoic acid - a metabolite the drug, detomidine, J. Chem. Res., M, 1992, p3026
M.T.M.Clements, K.J. Crowley, P.V. Kavanagh, M.A. Lennon, T.B.H. McMurry and N.P. Napier, Photochemistry of cyclic enones. Part 9. Effects of electron donating and attracting substituents on the ene in the [2+2] cycloaddition reactions of 3-phenyl-5-(prop-2-enyl)cyclopent-2-enones, J. Chem Res., M, 1991, p2920