Michael Rowan
Professor of Neuropharmacology, Pharmacology & Therapeutics

Publications and Further Research Outputs

Peer-Reviewed Publications

Mitchell D.P, Rowan M, Loughman E, Ridge C.A, MacMahon P.J, Contrast monitoring techniques in CT pulmonary angiography: An important and underappreciated contributor to breast dose, European Journal of Radiology, 86, 2017, p184 - 189 Journal Article, 2017 URL DOI

Miller, A.M., Begley, E., Coen, R.F., Doyle, M., Dunne, J., Hutchinson, S., Kennelly, S.P., Kenny, R.A., Killeen, R.P., O'Dwyer, S., O'Neill, C., O'Sullivan, S.S., Rowan, M.J., Sheehy, N., McGuigan, C., Lawlor, B.A. , Clinical consensus guidelines on the application of cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: recommendations of the Irish Network for Biomarkers in Neurodegeneration., Irish Medical Journal, 109, (10), 2016, p1-13 Journal Article, 2016

Zhang D, Jin B, Ondrejcak T, Rowan M.J, Opposite in vivo effects of agents that stimulate or inhibit the glutamate/cysteine exchanger system xcâ, ' on the inhibition of hippocampal LTP by AÃ , Hippocampus, 26, (12), 2016, p1655 - 1665 Journal Article, 2016 URL DOI

Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang Y, Rowan M.J, Anwyl R, Han Y, Wang Q, Protection against ß-amyloid-induced synaptic and memory impairments via altering ß-amyloid assembly by bis(heptyl)-cognitin, Scientific Reports, 5, 2015, p10256- Journal Article, 2015 URL TARA - Full Text DOI

Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352 Journal Article, 2015 DOI TARA - Full Text

Levites Y, O-Nuallain B, Puligedda R.D, Ondrejcak T, Adekar S.P, Chen C, Cruz P.E, Rosario A.M, Macy S, Mably A.J, Walsh D.M, Vidal R, Solomon A, Brown D, Rowan M.J, Golde T.E, Dessain S.K, A human monoclonal IgG that binds Aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo, Journal of Neuroscience, 35, (16), 2015, p6265 - 6276 Journal Article, 2015 URL DOI

Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ, Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 369, (1633), 2014, p20130147 Journal Article, 2014 DOI TARA - Full Text

O'Malley, T.T. Oktaviani, N.A. Zhang, D. Lomakin, A. O'Nuallain, B. Linse, S. Benedek, G.B. Rowan, M.J. Mulder, F.A.A. Walsh, D.M., Aß dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies, Biochemical Journal, 461, (3), 2014, p413 - 426 Journal Article, 2014 DOI URL

Klyubin, I. Nicoll, A.J. Khalili-Shirazi, A. Farmer, M. Canning, S. Mably, A. Linehan, J. Brown, A. Wakeling, M. Brandner, S. Walsh, D.M. Rowan, M.J. Collinge, J., Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity, Journal of Neuroscience, 34, (18), 2014, p6140 - 6145 Journal Article, 2014 DOI URL TARA - Full Text

Hu, N.-W. Nicoll, A.J. Zhang, D. Mably, A.J. O'Malley, T. Purro, S.A. Terry, C. Collinge, J. Walsh, D.M. Rowan, M.J., MGlu5 receptors and cellular prion protein mediate amyloid-ß- facilitated synaptic long-term depression in vivo, Nature Communications, 5, 2014 Journal Article, 2014 DOI TARA - Full Text URL

Welzel, A.T. Maggio, J.E. Shankar, G.M. Walker, D.E. Ostaszewski, B.L. Li, S. Klyubin, I. Rowan, M.J. Seubert, P. Walsh, D.M. Selkoe, D.J., Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity, Biochemistry, 53, (24), 2014, p3908 - 3921 Journal Article, 2014 URL DOI TARA - Full Text

Qi Y, Hu NW, Rowan MJ, Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus., Cerebral cortex (New York, N.Y. : 1991), 23, (4), 2013, p932-9 Journal Article, 2013 DOI TARA - Full Text

An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH, Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo., Molecular brain, 6, 2013, p47 Journal Article, 2013 DOI TARA - Full Text

Ondrejcak T, Wang Q, Kew JN, Virley DJ, Upton N, Anwyl R, Rowan MJ, Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus., European Journal of Pharmacology, 677, (1-3), 2012, p63 - 70 Journal Article, 2012 DOI

Klyubin I, Cullen WK, Hu NW, Rowan MJ, Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory., Molecular brain, 5, 2012, p25 Journal Article, 2012 TARA - Full Text DOI

Neng-Wei Hu, Tomas Ondrejcak, Michael J. Rowan, Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances, Pharmacology, 100, (4), 2012, p855-862 Journal Article, 2012 TARA - Full Text

Lanté F, Toledo-Salas JC, Ondrejcak T, Rowan MJ, Ulrich D, Removal of Synaptic Ca2+-Permeable AMPA Receptors during Sleep., The Journal of Neuroscience , 31, (11), 2011, p3953-61 Journal Article, 2011 TARA - Full Text DOI

O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM, A monoclonal antibody against synthetic Aß dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aß., Journal of neurochemistry, 119, (1), 2011, p189-201 Journal Article, 2011 DOI

Klyubin, I, Wang, Q, Reed, MN, Irving, EA, Upton, N, Hofmeister, J, Cleary, JP, Anwyl, R, Rowan, MJ, Protection against Abeta-mediated rapid disruption of synaptic plasticity and memory by memantine., Neurobiology of Aging, 32, 2011, p614 - 633 Journal Article, 2011 DOI

Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J, Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites., Nature Communications, 2, (336), 2011 Journal Article, 2011 TARA - Full Text DOI

Barry, A.E., Klyubin, I., McDonald, J.M., Mably, A.J., Farrell, M.A., Scott, M., Walsh, D.M., Rowan, M.J., Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP In Vivo is prevented by immunotargeting cellular prion protein, Journal of Neuroscience, 31, (20), 2011, p7259-7263 Journal Article, 2011 TARA - Full Text

Ondrejcak, T., Klyubin, I., Hu, N.-W., Barry, A.E., Cullen, W.K., Rowan, M.J., Alzheimer's Disease Amyloid β-Protein and Synaptic Function , NeuroMolecular Medicine, 12, (1), 2010, p13-26 Journal Article, 2010 DOI

Ryan BK, Vollmayr B, Klyubin I, Gass P, Rowan MJ, Persistent inhibition of hippocampal long-term potentiation in vivo by learned helplessness stress., Hippocampus, 20, (6), 2010, p758-67 Journal Article, 2010 DOI

Adekar SP, Klyubin I, Macy S, Rowan MJ, Solomon A, Dessain SK, O'Nuallain B, Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains., The Journal of biological chemistry, 285, (2), 2010, p1066-74 Journal Article, 2010 DOI

Hu, N.-W., Klyubin, I., Anwyl, R., Rowan, M.J., GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo , Proceedings of the National Academy of Sciences of the United States of America, 106, (48), 2010, p20504-20509 Journal Article, 2010 TARA - Full Text

Welsby, PJ, Rowan, MJ, Anwyl, R, Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus., The European Journal of Neuroscience, 29, (1), 2009, p65-75 Journal Article, 2009 DOI

Wang, Q.-W., Rowan, M.J., Anwyl, R., Inhibition of LTP by beta-amyloid is prevented by activation of β2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway , Neurobiology of Aging, 30, (10), 2009, p1608-1613 Journal Article, 2009 DOI

Ryan, B, Musazzi, L, Mallei, A, Tardito, D, Gruber, SH, El Khoury, A, Anwyl, R, Racagni, G, Mathé, AA, Rowan, MJ, Popoli, M, Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression., International Journal of Neuropsychopharmacology, 12, (4), 2009, p553-559 Journal Article, 2009 TARA - Full Text DOI

Kotilinek, L.A., Westerman, M.A., Wang, Q., Panizzon, K., Lim, G.P., Simonyi, A., Lesne, S., Agnieszka Falinska, Linda H. Younkin, Steven G. Younkin, Michael Rowan, James Cleary, Roi Ann Wallis, Grace Y. Sun, Greg Cole, Sally Frautschy, Roger Anwyl and Ashe, K.H., Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity , Brain , 131, (3), 2008, p651-664 Journal Article, 2008 TARA - Full Text

Ryan, BK, Anwyl, R, Rowan, MJ, 5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress., Neuropharmacology, 55, (2), 2008, p175-182 Journal Article, 2008 DOI

Wang, Q., Klyubin, I., Wright, S., Griswold-Prenner, I., Rowan, M.J., Anwyl, R., αv integrins mediate beta-amyloid induced inhibition of long-term potentiation , Neurobiology of Aging , 29, (10), 2008, p1485-1493 Journal Article, 2008 DOI

Shankar, GM, Li, S, Mehta, TH, Garcia-Munoz, A, Shepardson, NE, Smith, I, Brett, FM, Farrell, MA, Rowan, MJ, Lemere, CA, Regan, CM, Walsh, DM, Sabatini, BL, Selkoe, DJ, Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory., Nature Medicine, 14, (8), 2008, p837-842 Journal Article, 2008 TARA - Full Text DOI

Hu, NW, Smith, IM, Walsh, DM, Rowan, MJ, Soluble amyloid-β peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo , Brain : a Journal of Neurology, 131, (9), 2008, p2414-2424 Journal Article, 2008 DOI

Hayes, J., Li, S., Anwyl, R., Rowan, M.J., A role for protein kinase A and protein kinase Mζ in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo, Neuroscience , 151, (2), 2008, p604-612 Journal Article, 2008 DOI

Wu, J., Harney, S., Rowan, M.J., Anwyl, R., Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro , Neuroscience Letters, 436, (2), 2008, p235-238 Journal Article, 2008 DOI

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ, Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization., The Journal of Neuroscience, 28, (16), 2008, p4231-7 Journal Article, 2008 DOI TARA - Full Text

Amico, F., Spowart-Manning, L., Anwyl, R., Rowan, M.J., Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat , European Journal of Pharmacology , 577, (1-3), 2007, p71-77 Journal Article, 2007 DOI

Wang, Q., Chang, L., Rowan, M.J., Anwyl, R., evelopmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus , Neuroscience, 144, (1), 2007, p110-118 Journal Article, 2007 DOI

Rowan, M.J., Klyubin, I., Wang, Q., Hu, N.W., Anwyl, R., Synaptic memory mechanisms: Alzheimer's disease amyloid β-peptide-induced dysfunction, Biochemical Society Transactions , 35, (5), 2007, p1219-1223 Journal Article, 2007 DOI

Li, S., Cullen, W.K., Anwyl, R., Rowan, M.J., Muscarinic acetylcholine receptor-dependent induction of persistent synaptic enhancement in rat hippocampus in vivo , Neuroscience, 144, (2), 2007, p754-761 Journal Article, 2007 DOI

Welsby, P.J., Rowan, M.J., Anwyl, R., Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP , Neuropharmacology , 53, (1), 2007, p188-195 Journal Article, 2007 DOI

Harney SC, Rowan MJ and Anwyl R, Long-Term Depression of NMDA receptor-mediated synaptic transmission is dependent upon activation of mGluR5 and is altered to LTP by low intracellular calcium buffering, Journal of Neuroscience, 26, (4), 2006, p1128 - 1132 Journal Article, 2006 DOI

Welsby, P., Rowan, M., Anwyl, R., Nicotinic receptor-mediated enhancement of long-term potentiation involves activation of metabotropic glutamate receptors and ryanodine-sensitive calcium stores in the dentate gyrus , European Journal of Neuroscience , 24, (11), 2006, p3109-3118 Journal Article, 2006 DOI

Cooke, S.F., Wu, J., Plattner, F., Errington, M., Rowan, M., Peters, M., Hirano, A., Karl D. Bradshaw, Roger Anwyl, Timothy V. P. Bliss and Giese, K.P., Autophosphorylation of αCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse , Journal of Physiology , 574, (3), 2006, p805-818 Journal Article, 2006 DOI

Wu J, Rowan MJ, Anwyl R, Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro, Journal of Neurophysiology, 95, (6), 2006, p3519 - 3527 Journal Article, 2006 DOI

Salami, M., Rowan, M.J., Dose dependent effect of memantine on long-term potentiation in the CA1 area of the hippocampus , Yakhteh , 8, (29), 2006, p17-22+65 Journal Article, 2006

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ., Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo, Nature Medicine, 11, (5), 2005, p556 - 561 Journal Article, 2005 DOI

Wang Q, Wu J, Rowan MJ and Anwyl R , Beta-amyloid inhibition of LTP is mediated via tumor necrosis factor, European Journal of Neuroscience, 22, (11), 2005, p2827 - 2832 Journal Article, 2005 DOI

Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ, The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention., Biochemical Society Transactions , 33, (5), 2005, p1087 - 1090 Journal Article, 2005 URL

Rowan MJ, Klyubin I, Wang Q, Anwyl R., Synaptic plasticity disruption by amyloid beta protein: modulation by potential Alzheimer's disease modifying therapies, Biochemical Society Transactions, 33, (Part 4), 2005, p563 - 567 Journal Article, 2005 URL

Wu J., Rush AM, Rowan MJ and Anwyl R, Synaptically stimulated induction of group I metabotropic glutamate receptor-dependent long-term depression and depotentiation is inhibited by prior activation of metabotropic glutamate receptors and protein kinase C , Neuroscience, 123, (2), 2004, p507 - 514 Journal Article, 2004 DOI

Wu J, Rowan MJ and Anwyl R., An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro, Neuropharmacology, 46, (3), 2004, p311 - 317 Journal Article, 2004 DOI

Rowan MJ, Klyubin I, Wang Q, Anwyl R., Mechanisms of the inhibitory effects of amyloid beta-protein on synaptic plasticity, Experimental Gerontology, 39, (11-12), 2004, p1661 - 1667 Journal Article, 2004 DOI

O'Reilly MA, Cunningham CJ, Lawlor BA, Walsh CD, Rowan MJ, The effect of the menstrual cycle on electrophysiological and behavioral measures of memory and mood, Psychophysiology, 41, (4), 2004, p592 - 603 Journal Article, 2004 DOI

Ovsepian SV, Anwyl R, Rowan MJ., Endogenous acetylcholine lowers the threshold for long-term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study, European Journal of Neuroscience, 20, (5), 2004, p1267 - 1275 Journal Article, 2004 DOI

Wang Q, Rowan MJ, Anwyl R, Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide, The Journal of Neuroscience, 24, (27), 2004, p6049 - 6056 Journal Article, 2004 TARA - Full Text DOI

Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ , Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo, European Journal of Neuroscience, 19, (10), 2004, p2839 - 2846 Journal Article, 2004 DOI

Wang Q, Walsh DM, Rowan MJ, Selkoe DJ and Anwyl R , Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid {beta}-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5, Journal of Neuroscience, 24, (13), 2004, p3370 - 3378 Journal Article, 2004 DOI

Li, S., Cullen, W. K., Anwyl, R. and Rowan, M. J., Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty, Nature Neuroscience, 6, 2003, p526 - 531 Journal Article, 2003 DOI

Rowan MJ, Klyubin I, Cullen WK, Anwyl R., Synaptic plasticity in animal models of early Alzheimer's disease, Philosophical Transactions of the Royal Society B: Biological Sciences, 358, (1432), 2003, p821 - 828 Journal Article, 2003 DOI

Gisabella B, Rowan MJ, Anwyl R., Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro, Neuroscience , 121, (2), 2003, p297 - 305 Journal Article, 2003 DOI

Li S, Cullen WK, Anwyl R and Rowan MJ , Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty, Nature Neuroscience, 6, (5), 2003, p526 - 531 Journal Article, 2003 DOI

Shakesby AC, Anwyl R and Rowan MJ , Overcoming the effects of stress on synaptic plasticity in the intact hippocampus:rapid action of serotonergic and antidepressant agents, Journal of Neuroscience , 22, (9), 2002, p3638 - 3644 Journal Article, 2002 URL

Walsh, D. M., IKlyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J. and Selkoe, D. J. , Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, (6880), 2002, p535 - 539. Journal Article, 2002 DOI

Rush, A.M., Kilbride, J., Rowan, M.J., Anwyl, R., Presynaptic group III mGluR modulation of short-term plasticity in the lateral perforant path of the dentate gyrus in vitro, Brain Research, 952, (1), 2002, p38-43 Journal Article, 2002 DOI

Walsh DM Klyubin I, Fadeeva JV, Cullen WK, Wolfe MS, Anwyl R, Rowan MJ and Selkoe DJ, Naturally secreted oligomers of the Alzheimers amyloid B-protein inhibit hippocampal long-term potentiation in vivo, Nature, 416, 2002, p535 - 539 Journal Article, 2002 DOI

Rush AM, Wu J, Rowan MJ and Anwyl, R, Group I Metabotropic Glutamate Receptor (mGluR)-Dependent Long-Term Depression Mediated via p38 Mitogen-Activated Protein Kinase Is Inhibited by Previous High-Frequency Stimulation and Activation of mGluRs and Protein Kinase C in the Rat Dentate Gyrus In Vitro , Journal of Neuroscience , 22, (12), 2002, p6121 - 6128 Journal Article, 2002 URL

Carney R, Dardis C, Cullen WK, Felipo V, Anwyl R, Rowan MJ, Early spatial memory deficit induced by 2,5-hexanedione in the rat., Toxicology Letters, Mar 10, 128, (1-3), 2002, p107 - 115 Journal Article, 2002 DOI

Kilbride, J., Rush, A.M., Rowan, M.J., Anwyl, R., Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro, Journal of Neurophysiology, 85, (6), 2001, p2509-2515 Journal Article, 2001 URL

A. M. Rush, J. Wu, M. J. Rowan, R. Anwyl, Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus, Neuroscience, 105, (2), 2001, p335 - 341 Journal Article, 2001 DOI

Kim, J. H., Anwyl, R., Suh, Y. H., Djamgoz, M. B. and Rowan, M. J. , Use-dependent effects of amyloidogenic fragments of ß-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo, Journal of Neuroscience , 21, (4), 2001, p1327 - 1333. Journal Article, 2001 URL

Rush, A.M., Rowan, M.J, Anwyl, R., Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro, Neuroscience Letters, 298, (3), 2001, p175-178 Journal Article, 2001 DOI

Wu, J, Rush, A, Rowan, M.J., Anwyl, R., MDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro, Journal of Physiology, 533, (3), 2001, p745-755 Journal Article, 2001 DOI

Breakwell, N.A., Huang, L.Q., Rowan, M.J., Anwyl, R, Erratum: DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus (European Journal of Pharmacology (1997) 322 (173-178) PII: S0014299997000150), 2000, - 85 Miscellaneous, 2000 DOI

S. Li, R. Anwyl, M. J. Rowan, A persistent reduction in short-term facilitation accompanies long-term potentiation in the CA1 area in the intact hippocampus, Neuroscience, 100, (2), 2000, p213 - 220 Journal Article, 2000 DOI

Camodeca, N., Breakwell, N.A., Rowan, M.J., Anwyl, R, Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro, Neuropharmacology, 38, (10), 1999, p1597-1606 Journal Article, 1999 DOI

Huang, L., Rowan, M.J., Anwyl, R., Induction of long-lasting depression by (+)-α-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro, European Journal of Pharmacology, 366, (2-3), 1999, p151-158 Journal Article, 1999 DOI

Breakwell, N.A. Rowan, M.J., Anwyl, R., Erratum: (+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor (Journal of Neurophysiology (March 1998) 79 (1270-1276)), 1999, - xii Miscellaneous, 1999

Breakwell, N.A., Rowan, M.J., Anwyl, R., Erratum: (+)-MCPG blocks induction of LTP in CA 1 of rat hippocampus via agonist action at an mGluR group II receptor (Journal of Neurophysiology (March 1998) 79 (1270-1276)), 1999, - 12 Miscellaneous, 1999

Huang, L.-Q., Rowan, M.J., Anwyl, R., Role of protein kinases A and C in the induction of mGluR-dependent long-term depression in the medial perforant path of the rat dentate gyrus in vitro, Neuroscience Letters, 274, (2), 1999, p71-74 Journal Article, 1999 DOI

Huang, L., Killbride, J., Rowan, M.J., Anwyl, R, Activation of mGluRII induces LTD via activation of protein kinase A and protein kinase C in the dentate gyrus of the hippocampus in vitro, Neuropharmacology, 38, (1), 1999, p73-83 Journal Article, 1999 DOI

Wu, J., Wang, Y., Rowan, M.J., Anwyl, R., Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro, Journal of Neuroscience, 18, (10), 1998, p3589-3596 Journal Article, 1998 URL

Rowan MJ, Anwyl R, Xu L., Stress and long-term synaptic depression, Molecular Psychiatry, 3, (6), 1998, p472-474 Journal Article, 1998 URL

Camodeca, N., Rowan, M.J., Anwyl, R., Induction of LTD by increasing extracellular Ca2+ from a low level in the dentate gyrus in vitro, Neuroscience Letters, 255, (1), 1998, p53-56 Journal Article, 1998 DOI

N. A. Breakwell, M. J. Rowan, and R. Anwyl , (+)-MCPG Blocks Induction of LTP in CA1 of Rat Hippocampus via Agonist Action at an mGluR Group II Receptor , Journal of Neurophysiology, 79, (3), 1998, p1270 - 1276 Journal Article, 1998 URL

Xu, L., Anwyl, R. and Rowan, M. J. , Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus, Nature, 394, 1998, p891 - 894 Journal Article, 1998 DOI

Kilbride, J., Huang, L, Rowan, M.J., Anwyl, R., Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV, European Journal of Pharmacology, 356, (2-3), 1998, 149-157 Journal Article, 1998 DOI

Wang, Y., Wu, J., Rowan, M.J., Anwyl, R., Role of protein kinase C in the induction of homosynaptic long-term depression by brief low frequency stimulation in the dentate gyrus of the rat hippocampus in vitro, Journal of Physiology, 513, (2), 1998, p467-475 Journal Article, 1998 DOI

Xu, L., Holscher, C., Anwyl, R., Rowan, M.J., Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress, Proceedings of the National Academy of Sciences of the United States of America, 95, (6), 1998, p3204-3208 Journal Article, 1998 DOI

Wang, Y, Rowan, M.J., Anwyl, R., Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores, Journal of Neurophysiology, 77, (2), 1997, p812-825 Journal Article, 1997 URL

Hölscher, C., McGlinchey, L., Anwyl, R. Rowan, M.J., HFS-induced long-term potentiation of LFS-induced depotentiation in area CA1 of the hippocampus are not good models for learning, Psychopharmacology, 130, (2), 1997, p174-182 Journal Article, 1997 DOI

McGahon B, Holscher C, McGlinchey L, Rowan MJ, Lynch MA., Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus., Learning and Memory, 3, (4), 1997, p296 - 304 Journal Article, 1997 URL DOI

Christian Hölscher, Roger Anwyl and Michael J. Rowan, Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo, European Journal of Pharmacology, 322, (2-3), 1997, p155 - 163 Journal Article, 1997 DOI

Doyle, C.A., Cullen, W.K., Rowan, M.J., Anwyl, R, Low-frequency stimulation induces homosynaptic depotentiation but not long-term depression of synaptic transmission in the adult anaesthetized and awake rat hippocampus in vivo, Neuroscience, 77, (1), 1997, p75-85 Journal Article, 1997 DOI

Hölscher, C., Anwyl, R., Rowan, M.J., Block of theta-burst-induced long-term potentiation by (1S,3S)-1- aminocyclopentane-1,3-dicarboxylic acid: further evidence against long-term potentiation as a model for learning, Neuroscience, 81, (1), 1997, p17-22 Journal Article, 1997 DOI

Huang, L., Rowan, M.J., Anwyl, R., mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro, NeuroReport, 8, (3), 1997, 687-693 Journal Article, 1997 URL

Cullen, William K.; Suh, Yoo-Hun; Anwyl, Roger; Rowan, Michael J, Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments, NeuroReport, 8, (15), 1997, p3213-3217 Journal Article, 1997 URL

Breakwell, N.A., Huang, L., Rowan, M.J., Anwyl, R., DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus, European Journal of Pharmacology, 322, (2-3), 1997, p173-178 Journal Article, 1997 DOI

Hölscher, C., Anwyl, R., Rowan, M., Block of HFS-induced LTP in the dentate gyrus by 1S,3S-ACPD: Further evidence against LTP as a model for learning, NeuroReport, 8, (2), 1997, p451-454 Journal Article, 1997 URL

Wang, Y., Rowan, M.J., Anwyl, R, LTP induction dependent on activation of Ni2+-sensitive voltage-gated calcium channels, but not NMDA receptors, in the rat dentate gyrus in vitro, Journal of Neurophysiology, 78, (5), 1997, p2574-2581 Journal Article, 1997 URL

Huang, L, Breakwell, N.A., Rowan, M.J., Anwyl, R., PCCG-IV inhibits the induction of long-term potentiation in the dentate gyrus in vitro, European Journal of Pharmacology, 332, (2), 1997, p161-165 Journal Article, 1997 DOI

Wu, J., Wang, Y., Rowan, M.J., Anwyl, R, Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro, Neuroscience, 78, (2), 1997, p393-398 Journal Article, 1997 DOI

Cullen, W.K., Wu, J., Anwyl, R., Rowan, M.J., β-Amyloid produces a delayed NMDA receptor-dependent reduction in synaptic transmission in rat hippocampus, NeuroReport, 8, (1), 1997, p87-92 Journal Article, 1997 URL

Xu, L, Anwyl, R., De Vry, J., Rowan, M.J., Effect of repeated ipsapirone treatment on hippocampal excitatory synaptic transmission in the freely behaving rat: Role of 5-HT(1A) receptors and relationship to anxiolytic effect, European Journal of Pharmacology, 323, (1), 1997, p59-68 Journal Article, 1997 DOI

Wang Y, Wu J, Rowan MJ, Anwyl R., Conditions for the induction of long-term potentiation and long-term depression by conjunctive pairing in the dentate gyrus in vitro, Journal of Neurophysiology, 78, (5), 1997, p2569-2573 Journal Article, 1997 URL

Hölscher, C., Anwyl, R., Rowan, M.J., Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can be depotentiated by stimulation on the negative phase in area CA1 in vivo, Journal of Neuroscience, 17, (16), 1997, p6470-6477 Journal Article, 1997 URL

Xu, L., Anwyl, R. and Rowan, M. J. , Behavioural stress facilitates the induction of long-term depression in the hippocampus, Nature, 387, 1997, p497 - 500 Journal Article, 1997 DOI

Wang, Y, Wu, J., Rowan, M.J., Anwyl, R., Ryanodine produces a low frequency stimulation-induced NMDA receptor-independent long-term potentiation in the rat dentate gyrus in vitro, Journal of Physiology, 495, (3), 1996, p755-767 Journal Article, 1996 URL

Doyle, C., Hölscher, C., Rowan, M.J., Anwyl, R, The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo, Journal of Neuroscience, 16, (1), 1996, p418-424 Journal Article, 1996 URL

Breakwell, N.A., Rowan, M.J., Anwyl, R., Metabotropic glutamate receptor dependent EPSP and EPSP-spike potentiation in area Ca1 of the submerged rat hippocampal slice, Journal of Neurophysiology, 76, (5), 1996, p3126-3135 Journal Article, 1996 URL

C Hölscher, L McGlinchey, R Anwyl, and M J Rowan, 7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat., Learning & Memory, 2, 1996, p267 - 278 Journal Article, 1996 DOI

Manahan-Vaughan, D., Anwyl, R., Rowan, M.J, The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT(1A) receptor, European Journal of Pharmacology, 294, (2-3), 1995, p617-624 Journal Article, 1995 DOI

O'Connor, J.J., Wu, J., Rowan, M.J, Anwyl, R., Potentiation of N-methyl-D-aspartate-receptor-mediated currents detected using the excised patch technique in the hippocampal dentate gyrus, Neuroscience, 69, (2), 1995, p363-369 Journal Article, 1995 DOI

Wu, J., Anwyl, R., Rowan, M.J., β-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus, NeuroReport, 6, (17), 1995, p2409-2413 Journal Article, 1995

Wu, J., Anwyl, R., Rowan, M.J., β-amyloid-(1-40) increases long-term potentiation in rat hippocampus, European Journal of Pharmacology, 284, (3), 1995, pR1-R3 Journal Article, 1995 DOI

O'Connor, J.J., Rowan, M.J., Anwyl, R, Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current: Investigations of the involvement of mGlu receptors, Journal of Neuroscience, 15, (3), 1995, p2013-2020 Journal Article, 1995 URL

O'Mara, S.M., Rowan, M.J., Anwyl, R., Metabotropic glutamate receptor-induced homosynaptic long-term depression and depotentiation in the dentate gyrus of the rat hippocampus in vitro, Neuropharmacology, 34, (8), 1995, p983-989 Journal Article, 1995 DOI

O'Mara, S.M., Rowan, M.J., Anwyl, R., Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus, Neuroscience, 68, (3), 1995, p621-624 Journal Article, 1995 DOI

Wang Y, Rowan MJ, Anwyl R., (RS)-alpha-Methyl-4-carboxyphenylglycine inhibits long-term potentiation only following the application of low frequency stimulation in the rat dentate gyrus in-vitro, Neuroscience Letters, 197, (3), 1995, p207 - 210 Journal Article, 1995

Manahan-Vaughan, D., Anwyl, R., Rowan, M.J., Adaptive changes in 5-HT(1A) receptor-mediated hippocampal inhibition in the alert rat produced by repeated 8-OH-DPAT treatment, British Journal of Pharmacology, 112, (4), 1994, p1083-1088 Journal Article, 1994

Manahan-Vaughan D, Anwyl R, Rowan MJ., 5-HT1A receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment., European Journal of Pharmacology, 260, (2-3), 1994, p149 - 155 Journal Article, 1994 DOI

O'Connor, J. J., Rowan, M. J. and Anwyl, R. , Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation, Nature, 367, (6463), 1994, p557 - 559 Journal Article, 1994 DOI

O'Connor, J.J., Rowan, M.J., Anwyl, R, Long-lasting potentiation of the NMDA receptor-mediated EPSC is inhibited by metabotropic glutamate receptor antagonists in rat dentate granule cells in vitro, Journal of Physiology, 473, 1993, p170P Journal Article, 1993

O'Connor, J.J., Rowan, M.J., Anwyl, R, Potentiation of the isolated NMDA receptor-mediated excitatory postsynaptic current following metabotropic glutamate receptor activation and tetanic stimulation in rat hippocampal cells, Journal of Physiology, 473, 1993, 47P Journal Article, 1993

O'Connor, J.J., Rowan, M.J., Anwyl, R., Use-dependent effects of acute and chronic treatment with imipramine and buspirone on excitatory synaptic transmission in the rat hippocampus in vivo, Naunyn-Schmiedeberg's Archives of Pharmacology, 348, (2), 1993, p158-163 Journal Article, 1993

O'Connor, J.J., Rowan, M.J., Anwyl, R., Erratum: Serotoningergic depression of auditory evoked responses recorded in the rat hippocampus: Effect of repeated buspirone treatment (Brain Research, 573 (1992) (190-196)), 1992, - 179 Miscellaneous, 1992 DOI

O'Connor, J.J., Rowan, M.J., Anwyl, R, Serotoninergic depression of auditory evoked responses recorded in the rat hippocampus: Effect of repeated buspirone treatment, Brain Research, 573, (2), 1992, p190-196 Journal Article, 1992 DOI

McGuinness, N., Anwyl, R., Rowan, M.J., Enhancement of long-term potentiation by an agonist of the metabotropic glutamate receptor in the rat hippocampal slice , Journal of Physiology, 446, 1992, p442P Journal Article, 1992

McGuinness, N., Anwyl, R., Rowan, M., Trans-ACPD enhances long-term potentiation in the hippocampus, European Journal of Pharmacology, 197, (2-3), 1991, p231-232 Journal Article, 1991 DOI

McGuinness, N., Anwyl, R., Rowan, M, The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice, NeuroReport, 2, (11), 1991, p688-690 Journal Article, 1991

McGuinness, N., Anwyl, R., Rowan, M., Inhibition of an N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice, Brain Research, 562, (2), 1991, p335-338 Journal Article, 1991 DOI

McGuinness, N., Anwyl, R., Rowan, M., The effects of external calcium on the N-methyl-D-aspartate induced short-term potentiation in the rat hippocampal slice, Neuroscience Letters, 131, (1), 1991, p13-16 Journal Article, 1991 DOI

O'Connor JJ, Rowan MJ, Anwyl R., Actions of 5-HT1 ligands on excitatory synaptic transmission in the hippocampus of alert rats., British Journal of Pharmacology, 101, (1), 1990, p171 - 177 Journal Article, 1990 URL

John J. O'Connor, Michael J. Rowan and Roger Anwyl, Serotonergic involvement in the inhibitory effects of repeated buspirone treatment on synaptic transmission in the hippocampus, European Journal of Pharmacology, 167, (1), 1989, p21-29 Journal Article, 1989 DOI

Anwyl, R., Mulkeen, D., Rowan, M.J., The role of N-methyl-D-aspartate receptors in the generation of short-term potentiation in the rat hippocampus , Brain Research, 503, (1), 1989, p148-151 Journal Article, 1989 DOI

Anwyl, R., Lee, W.-L., Rowan, M., The role of calcium in short-term potentiation in the rat hippocampal slice , Brain Research , 459, (1), 1988, p192-195 Journal Article, 1988 DOI

Rowan, M.J., O'Conner, J.J., Anwyl, R., Changes in auditory evoked responses and in the inhibitory action of 5-hydroxytryptophan following chronic treatment with imipramine in the rat , Psychopharmacology , 96, (3), 1988, p408-413 Journal Article, 1988 DOI

Mulkeen, D., Anwyl, R., Rowan, M., The effects of external calcium on long-term potentiation in the rat hippocampal slice , Brain Research, 447, (2), 1988, p234-238 Journal Article, 1988 DOI

Anwyl, R., Walshe, J., Rowan, M., Electroconvulsive treatment reduces long-term potentiation in rat hippocampus , Brain Research , 435, (1-2), 1987, p377-379 Journal Article, 1987 DOI

Lee WL, Anwyl R, Rowan M., Caffeine inhibits post-tetanic potentiation but does not alter long-term potentiation in the rat hippocampal slice, Brain Research, 426, (2), 1987, p250-256 Journal Article, 1987 DOI

W.L. Lee, R. Anwyl and M. Rowan, 4-aminopyridine-mediated increase in long-term potentiation in CA1 of the rat hippocampus, Neuroscience Letters, 70, (1), 1986, p106 - 109 Journal Article, 1986 DOI

Rowan, M.J., Anwyl, R., Neurophysiological effects of buspirone and isapirone in the hippocampus: Comparison with 5-hydroxytryptamine, European Journal of Pharmacology, 132, (1), 1986, p93-96 Journal Article, 1986 DOI

Anwyl, R., Rowan, M.J., Frequency-dependent block of field potentials in the rat hippocampal slice caused by tricyclic antidepressants, British Journal of Pharmacology, 86, (1), 1985, p201-208 Journal Article, 1985 URL

Rowan, M.J., Anwyl, R., The effect of prolonged treatment with tricyclic antidepressants on the actions of 5-hydroxytryptamine in the hippocampal slice of the rat, Neuropharmacology, 24, (2), 1985, p131-137 Journal Article, 1985 DOI

Anwyl, R., Rowan, M.J., Neurophysiological evidence for tricyclic antidepressant-induced decreased beta-adrenergic responsiveness in the rat hippocampus , Brain Research, 300, (1), 1984, p192-194 Journal Article, 1984 DOI

Research Expertise

Projects

  • Title
    • Mechanisms of the synaptic plasticity disrupting actions of Aß
  • Funding Agency
    • Science Foundation Ireland Investigator Programme Grant
  • Date From
    • 2006
  • Date To
    • 2010
  • Title
    • Neurocardiovascular influences on cognitive functioning
  • Summary
    • This Translational Programme Grant is a collaboration with Prof RoseAnne Kenny and Prof Brian Lawlor
  • Funding Agency
    • Health Research Board
  • Date From
    • 2006
  • Date To
    • 2011
  • Title
    • MEMOLOAD
  • Funding Agency
    • European Union Framework 7
  • Date From
    • 2007
  • Date To
    • 2011