Christian Kerskens
Lead Physicist, Trinity Inst. of Neurosciences (TCIN)
Associate Research Lecturer, Clinical Medicine

Biography

Education: 1997 Doctor of Science (Dr. rerum naturalium), University of Cologne 1997 Thesis: Development of theoretical and experimental methods of measuring brain perfusion using NMR, Max-Planck-Institute for neurological Research, Cologne (Dept. for Experimental Neurology, Prof. Hossmann) 1993 Masters-Degree in Physics (Diplom Physik), University of Cologne 1992/3 Masters thesis, Institute for Nuclear Physics, University of Cologne 1988-93 studies of theoretical and experimental physics, at the University of Cologne Professional Background: Since 2005 Lead physicist Institute of Neuroscience, Dublin Associate Research Lecturer, Clinical Medicine, Trinity College 2002-04 Senior MR-physicist, FC Donders Centre for cognitive Neuroimaging, Nijmegen 1997-2001 MR-physicist, Charité, Medical Faculty of the Humboldt University, Berlin, Neurological Clinic: Clinical Research Group, subproject: Acute-diagnostic and therapy-monitoring by human media-infarct with functional NMR and near-infrared spectroscopy 1993-1996 Scholarship to Max-Planck-Institute for neurological Research, Cologne (Dept. for Experimental Neurology, Prof. Hossmann)

Publications and Further Research Outputs

Peer-Reviewed Publications

Syed salman Shahid, Christian Kerskens, Robert Gaul, Caitriona Lally, Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging, European Molecular Imaging Meeting, Germany, 5-04-2017, 2017 Poster, 2017 TARA - Full Text

Syed Salman Shahid, Robert Gaul, Christian Kerskens, Vittoria Flamini, Caitríona Lally, Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging - Comparison of intact vs. open cut tissue , Physics in Medicine and Biology, 62, (23), 2017, p8850 - 8868 Journal Article, 2017 TARA - Full Text URL

Gormley, S., Rouine, J., McIntosh, A., Kerskens, C., Harkin, A., Glial fibrillary acidic protein (GFAP) immunoreactivity correlates with cortical perfusion parameters determined by bolus tracking arterial spin labelling (bt-ASL) magnetic resonance (MR) imaging in the Wistar Kyoto rat, Physiology and Behavior, 160, 2016, p66-79 Journal Article, 2016 DOI

Rahman M.M, Callaghan C.K, Kerskens C.M, Chattarji S, O'Mara S.M, Early hippocampal volume loss as a marker of eventual memory deficits caused by repeated stress, Scientific Reports, 6, 2016, p29127 Journal Article, 2016 TARA - Full Text URL DOI

Rouine J, Kelly ME, Jennings-Murphy C, Duffy P, Gorman I, Gormley S, Kerskens CM, Harkin A, Investigation of the mechanisms mediating MDMA "Ecstasy"-induced increases in cerebro-cortical perfusion determined by btASL MRI., Psychopharmacology, 232, (9), 2015, p1501-1513 Journal Article, 2015 DOI

O'Neill A, D'Souza A, Samson A.C, Carballedo A, Kerskens C, Frodl T, Dysregulation between emotion and theory of mind networks in borderline personality disorder, Psychiatry Research - Neuroimaging, 231, (1), 2015, p25 - 32 Journal Article, 2015 DOI URL

Flamini V, Creane A.P, Kerskens C.M, Lally C, Imaging and finite element analysis: A methodology for non-invasive characterization of aortic tissue, Medical Engineering and Physics, 37, (1), 2015, p48 - 54 Journal Article, 2015 URL DOI

Rahman MM, Kerskens CM, Chattarji S, O'Mara SM, Chronic immobilization stress occludes in vivo cortical activation in an animal model of panic induced by carbon dioxide inhalation., Frontiers in behavioral neuroscience, 8, 2014, p311 Journal Article, 2014 DOI TARA - Full Text

Gigliucci V, Gormley S, Gibney S, Rouine J, Kerskens C, Connor TJ, Harkin A, Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulcectomised rat model of depression, European Neuropsychopharmacology, 24, (8), 2014, p1349 - 1361 Journal Article, 2014 DOI

Flamini V, Kerskens C, Moerman K, Simms CK and Lally C, Fibre orientation of fresh and frozen porcine aorta determined non-invasively, Medical Engineering and Physics, 35, (6), 2013, 765-776 Journal Article, 2013 DOI

Borase T, Ninjbadgar T, Kapetanakis A, Roche S, O'Connor R, Kerskens C, Heise A, Brougham D.F, Stable aqueous dispersions of glycopeptide-grafted selectably functionalized magnetic nanoparticles, Angewandte Chemie - International Edition, 52, (11), 2013, p3164 - 3167 Journal Article, 2013 URL DOI

O'Neill A, D'Souza A, Carballedo A, Joseph S, Kerskens C, Frodl T, Magnetic resonance imaging in patients with borderline personality disorder: a study of volumetric abnormalities., Psychiatry research, 213, (1), 2013, p1-10 Journal Article, 2013

Rouine, J, Gobbo, OL, Campbell, M, Gigliucci, V, Ogden, I, Smith, KM, Duffy, P, Behan, B, Byrne, D, Kelly, ME, Blau, CW, Kerskens, CM, Harkin, A, MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI, BRITISH JOURNAL OF PHARMACOLOGY, 169, (5), 2013, p974-987 Journal Article, 2013 TARA - Full Text DOI

Blau CW, Cowley TR, O'Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly AM, Kerskens CM, Lynch MA, The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability., Neurobiology of aging, 33, (5), 2012, p1005.e23-35 Journal Article, 2012 DOI TARA - Full Text

Cowley TR, O'Sullivan J, Blau C, Deighan BF, Jones R, Kerskens C, Richardson JC, Virley D, Upton N, Lynch MA, Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP., Neurobiology of aging, 33, (1), 2012, p162-75 Journal Article, 2012 DOI TARA - Full Text

Griffin KM, Blau CW, Kelly ME, O'Herlihy C, O'Connell PR, Jones JFX, Kerskens CM, Propofol allows precise quantitative arterial spin labelling functional magnetic resonance imaging in the rat, NeuroImage, 51, (4), 2010, p1395-1404 Journal Article, 2010 TARA - Full Text

Vittoria Flamini, Christian Kerskens, Kevin Mattheus Moerman, Ciaran Simms and Caitríona Lally , Imaging Arterial Fibres Using Diffusion Tensor Imaging-Feasibility Study and Preliminary Results, EURASIP Journal on Advances in Signal Processing, 2010, (904091), 2010 Journal Article, 2010 URL DOI TARA - Full Text

Cowley RT, O'Sullivan J, Blau C; Deighan BF; Jones R; Kerskens C; Richardson JC; Virley D; Upton N; Lynch ML , Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP, Neurobiology of Aging, 2010 Journal Article, 2010

C. M. P. O'Tuathaigh, M. Harte, C. O'Leary, G. J. O'Sullivan, C. Blau, D. Lai, R. P. Harvey, O. Tighe, A. J. Fagan, C. Kerskens, G. Reynolds and J. L. Waddington, Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice , European Journal of Neuroscience, 2010 Journal Article, 2010

Michael E Kelly, Christoph W Blau, Karen M Griffin, Oliviero L Gobbo, James FX Jones and Christian M Kerskens, Quantitative functional magnetic resonance imaging of brain activity using bolus-tracking arterial spin labeling , Journal of Cerebral Blood Flow & Metabolism, 2010 Journal Article, 2010

Dunleavy M, Shinoda S, Schindler C, Ewart C, Dolan R, Gobbo OL, Kerskens CM, Henshall DC, Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis., The American journal of pathology, 176, (1), 2010, p330-42 Journal Article, 2010 DOI

Moerman, KM ; Kerskens, CM ; Lally, C ; Flamini, V ; Simms, CK , Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation, EURASIP Journal on Advances in Signal Processing, 2010, 2010, p942131 Journal Article, 2010 TARA - Full Text DOI

C. W. Blau, K. M. Griffin, O. L. Gobbo, J. F. Jones, and C. M. Kerskens, Fast bolus-tracking fMRI in medetomidine-sedated rats using intravascular tracer: towards quantitative fMRI, International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009 Conference Paper, 2009

M. E. Kelly, C. W. Blau, R. Bechara, M. A. Lynch, and C. M. Kerskens, Bolus-tracking arterial spin labeling; A new marker for age and age related neurological diseases, International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009 Conference Paper, 2009

Campbell, M, Nguyen, ATH, Kiang, AS, Tam, LCS, Gobbo, OL, Kerskens, C, Dhubhghaill, SN, Humphries, MM, Farrar, GJ, Kenna, PF, Humphries, P, An experimental platform for systemic drug delivery to the retina, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 2009 Journal Article, 2009

C.W. Blau, R.J. Kelly, C.M. Kerskens, M.A. Lynch, AGE-RELATED MAGNETIC RESONANCE RELAXOMETRY CHANGES IN RAT BRAIN CANNOT BE ACCOUNTED FOR BY CHANGES IN GREY MATTER VOLUME AS MEASURED BY VOXEL-BASED MORPHOMETRY (VBM)., MRI Satellite Symposium Presentations, 2009 Meeting Abstract, 2009

Christoph W. Blau, Thelma R. Cowley, Joan B. O'Sullivan, Raasay S. Jones, Christian M. Kerskens, Marina A. Lynch, The effect of the PPAR gamma agonist rosiglitazone on age-related changes in grey matter magnetic resonance relaxometry in the rat , Alzheimer's & Dementia: The Journal of the Alzheimer's Association , 5, (4, Supplement), 2009, pp207 - 208 Meeting Abstract, 2009 DOI

O. Gobbo, M. Campbell, A.Kiang, P. Kenna, C. Kerskens, G. J. Farrar, P. Humphries, RNAi-MEDIATED REVERSIBLE OPENING OF THE BLOOD-BRAIN AND BLOODRETINA BARRIER, MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Matthew Campbell, Anh T. H. Nguyen, Anna-Sophia Kiang, Lawrence C. S. Tam, Oliviero L. Gobbo, Christian Kerskens, Sorcha Ni Dhubhghaill, Marian M. Humphries, G.-Jane Farrar, Paul F. Kenna and Peter Humphries, An experimental platform for systemic drug delivery to the retina, Proceedings of the National Academy of Sciences of the United States, 106, (42), 2009, p17817 - 17822 Journal Article, 2009 TARA - Full Text DOI

Cooke JM, Kalmykov YP, Coffey WT, and Kerskens, CM, Langevin equation approach to diffusion magnetic resonance imaging, Physical Review E , 80, (061102), 2009 Journal Article, 2009 DOI TARA - Full Text URL

Kelly, M; Blau, C; Gobbo, O; Griffin, K; Jones, J; Kerskens, C , Functional bolus-tracking arterial spin labeling: a new approach to quantitative fMRI, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, JUN 29-JUL 03, 2009, 29, (S1), NATURE PUBLISHING GROUP, 2009 Meeting Abstract, 2009

J. Rouine, O. Gobbo, C. Kerskens, A. Harkin, Acute and persistent effects of 3,4- methylenedioxymethamphetamine (MDMA; ''ECSTASY'') on magnetic resonance contrast enhanced imaging of perfusion in the rat brain, Irish Journal of Medical Science, ROYAL ACADEMY OF MEDICINE IN IRELAND, SECTION OF BIOMEDICAL SCIENCES Annual Meeting 2009, 18th-19th June 2009, 178, (Supplement 12), 2009 Meeting Abstract, 2009 DOI

J. J. Gallagher, C. M. Kerskens, M. A. Lynch, Spatial learning in middle-aged APP/PS1 mice, but not T2 relaxation time, is associated with amyloid-plaque deposition, Irish Journal of Medical Science, ROYAL ACADEMY OF MEDICINE IN IRELAND, SECTION OF BIOMEDICAL SCIENCES Annual Meeting 2009, 18th-19th June 2009, 178, (Supplement 12), 2009 Meeting Abstract, 2009 DOI

Kelly, ME, Blau, CW, Kerskens, CM, Bolus-tracking arterial spin labelling: theoretical and experimental results, PHYSICS IN MEDICINE AND BIOLOGY, 54, 2009 Journal Article, 2009

C. Blau, R. Bechara, C. M. Kerskens, and M. A. Lynch, T2 relaxation time is decreased in hippocampus of aged rats: analysis of the effect of the peroxisome proliferator-activated , International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009 Conference Paper, 2009

R. Kelly, L. O' Dwyer, E. O' Hanlon, C. Connolly, M. Lynch, and C. Kerskens, An Investigation into Young and Aged Rat Brain Volume Differences by Optimized Voxel-Based Morphometry , International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009 Conference Paper, 2009

R. Kelly, C. Blau, E. O'Hanlon, C.G. Connolly, C. Kerskens, M.A. Lynch, OPTIMIZED VOXEL-BASED MORPHOMETRY AND T2 RELAXOMETRY REVEAL SIGNIFICNT AGE-RELATED DECREASES IN AREAS OF THE RAT BRAIN, MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Blau, CW (Blau, C. W.);Kelly, M; Griffin, KM; Jones, JFX); Kerskens, CM, Fast bolus-tracking function magnetic resonance imaging (fMRI) in medetomidine-sedated rats using intravascular tracer, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, JUN 29-JUL 03, 2009, 29, (S1), NATURE PUBLISHING GROUP, 2009 Meeting Abstract, 2009

Vittoria Flamini, Christian Kerskens, Caitríona Lally, AN ANISOTROPIC STRUCTURAL MODEL OF THE AORTIC WALL BASED ON TENSILE TESTS AND NON-INVASIVE 3D FIBRE ANALYSIS USING DIFFUSION TENSOR IMAGING, Proceedings of the ASME 2009 Summer Bioengineering Conference (SBC2009), Lake Tahoe, CA, USA, 2009 Conference Paper, 2009

R. J. Kelly, C. Blau, E. O' Hanlon, C. G. Connolly, C. Kerskens, M. Lynch, Optimized voxel-based morphometry of the rat brain reveals cortical and hippocampal volume decline with age, Proc Physiol Soc 15, PC208 , 2009 Poster, 2009

M. E. Kelly, C. W. Blau, O. L. Gobbo, K. M. Griffin, J. F. Jones, and C. M. Kerskens, Functional bolus-tracking arterial spin labeling; a new approach to quantitative fMRI , International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009 Conference Paper, 2009

R. E. Gonzalez-Reyes, K. Murphy, R. Bechara, C. Blau, C. Kerskens, M. Lynch, Evidence of an inverse correlation between T2 relaxation time and microglial activation in the cortex of aged rats, Proc Physiol Soc 15, C10, 2009 Meeting Abstract, 2009

M.E. Kelly, C.W. Blau, O.L. Gobbo, K.M. Griffin, J.FX. Jones, C.M. Kerskens, QUANTITATIVE FUNCTIONAL MAGNETIC RESONANCE IMAGING WITH BOLUSTRACKING ARTERIAL SPIN LABELLING, MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Cooke JM, Kalmykov YP, Coffey WT, and Kerskens, CM, Langevin equation approach to diffusion magnetic resonance imaging, Virtual Journal of Biological Physics Research, 18, (12), 2009 Journal Article, 2009

J. Rouine, B. Behan, M. Kelly, C. Blau, O. Gobbo, C. Kerskens, A. Harkin, PERFUSION MAGNETIC RESONANCE IMAGING USING SPIN LABELLING OF ARTERIAL WATER SHOWS INCREASED CORTICAL BLOOD FLOW FOLLOWING METHYLENEDIOXYMETHAMPHETAMINE (MDMA; "ECSTASY") ADMINISTRATION TO RATS., 2009 Meeting Abstract, 2009

Kelly, M; Blau, C; Bechara, R; Lynch, M; Kerskens, C , Bolus-tracking arterial spin labeling: a new marker for aging and age related neurological diseases, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, JUN 29-JUL 03, 2009, 29, (S1), 2009, pp87 - 87 Meeting Abstract, 2009

Arun Bokde, Michael Ewers, Yetunde Faluyi, Catherine Delaney, Abid Khattack, Ronan Collins, Christian Kerskens, Tara Coughlan, Siobhain Nibrihain, Ian Daly, Greg Swanwick, Desmond O'Neill, Harald Hampel, Alterations in activation between mild cognitive impaired subjects during a working memory task and resting coherent network , Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 5, (4, Supplement), 2009, pp23- Meeting Abstract, 2009 DOI

Christoph W. Blau, Thelma R. Cowley, Joan B. O'Sullivan, Raasay S. Jones, Christian M. Kerskens, Marina A. Lynch, The effect of the PPAR gamma agonist rosiglitazone on age-related changes in grey matter magnetic resonance relaxometry in the rat , Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 5, (4, Supplement), 2009, pp7 - 8 Meeting Abstract, 2009 DOI

J.J. Gallagher, R. Kelly, C.M. Kerskens, M.A. Lynch, THE AGE-RELATED DECREASE IN T2 RELAXATION TIME IS NOT EXACERBATED IN MALE APP/PS1 AT 8-9 MONTHS OF AGE., MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Gallagher, JJ, Tekoriute, R, O'Reilly, JA, Kerskens, C, Gun'ko, YK, Lynch, M, Bimodal magnetic-fluorescent nanostructures for biomedical applications, Journal of Materials Chemistry, 19, 2009, p4081 - 4084 Journal Article, 2009 TARA - Full Text

Corr, SA, Byrne, SJ, Tekoriute, R, Meledandri, CJ, Brougham, DF, Lynch, M, Kerskens, C, O'Dwyer, L, Gun'ko, YK, Linear assemblies of magnetic nanoparticles as MRI contrast agents, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 2008 Journal Article, 2008

Flamini V,Kerskens C, Lally C, Study of the 3D fibre distribution through a Porcine Aorta using diffusion tensor imaging, Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Sligo, 2008 Conference Paper, 2008

Cooke J, Kerskens CM, Enhancement of the detection of white matter anisotropy using time-varying diffusion gradients, 25th Annual Meeting of ESMRMB,, Valencia, Spain, October 2-4 2008, 2008 Meeting Abstract, 2008

J Gallagher, S. Lalor, R. Tekoriute, Y. Gun'ko, K.H. Mills, C. Kerskens, T2 and T2* measurements of a fluorescent magnetic contrast agent transfected to murine , 25th Annual Meeting of ESMRMB,, Valencia, Spain, October 2-4 2008, 2008 Meeting Abstract, 2008

Kelly ME, Blau CW, Kerskens CM, Bolus-tracking arterial spin labelling - theoretical and experimental results, 25th Annual Meeting of ESMRMB,, Valencia, Spain, October 2-4 2008, 2008 Meeting Abstract, 2008

Campbell M, Kiang AS, Kenna P, Kerskens C, Blau C, O'Dwyer L, Farrar J and Humphries P, Transient blood brain barrier breakage by RNA interference of Claudin-5, Human Molecular Genetics, 2008 Journal Article, 2008

Campbell, M, Kiang, AS, Kenna, PF, Kerskens, C, Blau, C, O'Dwyer, L, Tivnan, A, Kelly, JA, Brankin, B, Farrar, GJ, Humphries, P, RNAi-mediated reversible opening of the blood-brain barrier, JOURNAL OF GENE MEDICINE, 10, 2008 Journal Article, 2008

Brunecker, P, Endres, M, Nolte, CH, Schultze, J, Wegener, S, Jungehulsing, GJ, Muller, B, Kerskens, CM, Fiebach, JB, Villringer, A, Steinbrink, J, Evaluation of an AIF correction algorithm for dynamic susceptibility contrast-enhanced perfusion MR1, MAGNETIC RESONANCE IN MEDICINE, 60, 2008 Journal Article, 2008

Flamini V,Kerskens C, Lally C, Characterization of the 3D Fibre Distribution in a Porcine Aoarta using diffusion tensor imaging, Journal of Biomechanics , European Society of Biomechanics, Lucerne Switzerland, 41, 2008, ppS69- Conference Paper, 2008

Parkes, LM, Schwarzbach, JV, Bouts, AA, Deckers, RHR, Pullens, P, Kerskens, CM, Norris, DG, Quantifying the spatial resolution of the gradient echo and spin echo BOLD response at 3 Tesla, MAGNETIC RESONANCE IN MEDICINE, 54, 2005 Journal Article, 2005

Schmierer, K, Altmann, DR, Kassim, N, Kitzler, H, Kerskens, CM, Doege, CA, Aktas, O, Lunemann, JD, Miller, DH, Zipp, F, Villringer, A, Progressive change in primary progressive multiple sclerosis normal-appearing white matter: a serial diffusion magnetic resonance imaging study, MULTIPLE SCLEROSIS, 10, 2004 Journal Article, 2004

Parkes, LM, Fries, P, Kerskens, CM, Norris, DG, Reduced BOLD response to periodic visual stimulation, NEUROIMAGE, 21, 2004 Journal Article, 2004

Parkes LM,Bouts A, Deckers R, Pullens P, Kerskens CM, Norris DG, Schwarzbach JV, Determining the spatial resolution of the gradient echo and, European Society for Magnetic Resonance in Medicine (ESMRMB, 2004 Meeting Abstract, 2004

Krep, H, Bottiger, BW, Bock, C, Kerskens, CM, Radermacher, B, Fischer, M, Hoehn, M, Hossmann, KA, Time course of circulatory and metabolic recovery of cat brain after cardiac arrest assessed by perfusion- and diffusion-weighted imaging and MR-spectroscopy, RESUSCITATION, 58, 2003 Journal Article, 2003

Parkes LM, Kerskens CM, Norris DG., Characterisation of diffusion-weighted spin echo BOLD signal at 3T, International Society for Magnetic Resonance in Medicine, 11th scientific meeting and exhibition, Toronto, Canada, 2003 Conference Paper, 2003

Parkes LM, Kerskens CM, Norris DG, Characterisation of diffusion-weighted spin echo BOLD signal at 3T, International Society for Magnetic Resonance in Medicine, 11th scientific meeting and exhibition, Toronto, Canada, 2003 Conference Paper, 2003

Doege, CA, Kerskens, CM, Romero, BI, Brunecker, P, Junge-Hulsing, J, von Pannwitz, W, Muller, B, Villringer, A, Assessment of diffusion and perfusion deficits in patients with small subcortical ischemia, AMERICAN JOURNAL OF NEURORADIOLOGY, 24, 2003 Journal Article, 2003

Parkes LM, Kerskens CM, Norris DG, The BOLD Signal Amplitude is larger for Aperiodic Stimuli Compared to periodic stimuli, International Society for Magnetic Resonance in Medicine, 11th scientific meeting and exhibition, 2003 Conference Paper, 2003

Parkes LM, Kerskens CM, Norris DG, The BOLD Signal Amplitude is larger for Aperiodic Stimuli Compared to periodic stimuli, International Society for Magnetic Resonance in Medicine, 11th scientific meeting and exhibition, Toronto, Canada, 2003 Conference Paper, 2003

Brunecker P, Kerskens CM, Endres M, Schultze J, Doege CA, Mueller B, Dirnagl U, Villringer A, High precision measurement of mean transit time for pharmacological MRI, STROKE, 32, (1), 2001, p36 Journal Article, 2001

Kerskens CM, Doege CA, Romero B, Brunecker P, Villringer A, Perfusion and diffusion weighted MRI in human anterior choroidal artery infarction, International Society for Magnetic Resonance in Medicine, 9th scientific meeting and exhibition, Glasgow, Scotland, April 21-27, 2001 Conference Paper, 2001

Doege, CA, Tavakolian, R, Kerskens, CM, Romero, BI, Lehmann, R, Einhaupl, KM, Villringer, A, Perfusion and diffusion magnetic resonance imaging in human cerebral venous thrombosis, JOURNAL OF NEUROLOGY, 248, 2001 Journal Article, 2001

Cerebral blood flow, hemoglobin oxygenation, and water diffusion changes during stroke: fingerprinting with near-infrared spectroscopy and MRI in, Ischemic Blood Flow in the Brain, Tokyo, Springer-Verlag , 2001, [5. Dirnagl U, Obrig H, v. Pannwitz W, Kohl M, Kerskens C, Döge C, Lindauer U, Wolf T, Villringer A] Book Chapter, 2001

Doege, CA, Kerskens, CM, Romero, BI, Brunecker, P, von Pannwitz, W, Junge-Hulsing, J, Muller, B, Villringer, A, MRI of small human stroke shows reversible diffusion changes in subcortical gray matter, NEUROREPORT, 11, 2000 Journal Article, 2000

Doege, CA, Kerskens, CM, Romero, B, Brunecker, P, von Pannwitz, W, Junge-Hulsing, J, Muller, B, Villringer, A, Diffusion and perfusion imaging in acute diagnostics of cerebral ischaemia, KLINISCHE NEUROPHYSIOLOGIE, 31, 2000 Journal Article, 2000

Busch, E, Kruger, K, Allegrini, PR, Kerskens, CM, Gyngell, ML, Hoehn-Berlage, M, Hossmann, KA, Reperfusion after thrombolytic therapy of embolic stroke in the rat: Magnetic resonance and biochemical imaging, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 18, 1998 Journal Article, 1998

Schmitz B, Bock C, Hoehn-Berlage M, Kerskens CM, Bottiger BW, Hossmann KA, Recovery of the rodent brain after cardiac arrest: a functional MRI study, Magnetic Resonance in Medicine, 39, (5), 1998, p783 - 788 Journal Article, 1998

Kerskens CM, Entwicklung theoretischer und experimenteller Methoden zur Messung der Hirndurchblutung mit Hilfe der Kernspintomographie, Berlin, LogosVerlag, 1998 Book, 1998

Bock, C, Schmitz, B, Kerskens, CM, Gyngell, ML, Hossmann, KA, Hoehn-Berlage, M, Functional MRI of somatosensory activation in rat: Effect of hypercapnic up-regulation on perfusion- and BOLD-imaging, MAGNETIC RESONANCE IN MEDICINE, 39, 1998 Journal Article, 1998

Kerskens CM, Tavakolian R, Villringer A, A new mathematical description of the NMR signal of Brain perfusion in bolus track: determination of mean transit time in different brain regions in human, International Society for Magnetic Resonance in Medicine, 6th scientific meeting and exhibition, Sydney, April 18-24, 1998, 1998, pp46 Conference Paper, 1998

Bock C, Busch G, Brinker G, Krep H, Kerskens CM, Hossmann K-A, Hoehn-Berlage M, Simultaneous recordings of f-MRI and evoked cortical potentials during somatosensory stimulation in a alpha-chloralose anesthetized rats, International Society for Magnetic Resonance in Medicine, 5th scientific meeting and exhibition, April 12-18, 1997, 1997 Conference Paper, 1997

Busch E, Kerskens CM und Hoehn-Berlage M, Hyper- and hypointense areas observed concurrently on diffusion-weighted images in rats after 1 week of permanent focal cerebral ischemia, International Society for Magnetic Resonance in Medicine, 5th scientific meeting and exhibition, Vancouver, April 12-18, 1997, 1997 Conference Paper, 1997

Krep H, Böttiger BW, Bock C, Schmitz B, Kerskens CM, Hoehn-Berlage M und Hossmann K-A, Monitoring of brain recovery after cardiac arrest by combined perfusion- and diffusion-weighted imaging and MR-spectroscopy, International Society for Magnetic Resonance in Medicine, 5th scientific meeting and exhibition, Vancouver, April 12-18, 1997, 1997 Conference Paper, 1997

Stroke treatment with a new nonselective cation channel blocker extends the therapeutical window: A longitudinal diffusion nmr imaging study in, editor(s)Krieglstein J and Oberpichler-Schwenk H , Pharmacology of Cerebral Ischemia , Stuttgart, Medpharm Scientific Publishers, 1996, [Hoehn-Berlage M, Busch E, Eis M, Schmitz B, Kerskens CM, Uhlenkueken U, Gyngell ML, K-A Hossmann] Book Chapter, 1996

Schmitz B, Bock C, Kerskens CM, Hoehn-Berlage M, Boettiger BW, Hossmann K-A, Recovery of the coupling of cerebral blood flow to neuronal activation following cardiac arrest in rats: a functional MRI study, International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, April 27-May 3, 1996, 1996 Conference Paper, 1996

Busch E, Krueger K, Allegrini PR, Kerskens CM, Hoehn-Berlage M, Hossmann K-A, Rt-pa treatment of thromboembolic stroke in rat: assessment by repeated ultrafast arterial spin tagging perfusion., International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, April 27-May 3, 1996, 1996 Conference Paper, 1996

Hoehn-Berlage M, Eis M, Busch E, Schmitz B, Gyngell ML, Kerskens CM, Hossmann K-A, Stroke therapy with a new non-selective cation channel blocker: diffusion NMR imaging and metabolite mapping, International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, April 27-May 3, 1996, 1996 Conference Paper, 1996

Functional magnetic resonance imaging after cardiac arrest in rat in, editor(s)Krieglstein J and Oberpichler-Schwenk H , Pharmacology of Cerebral Ischemia , Stuttgart, Medpharm Scientific Publishers, 1996, [Hossmann K-A, Schmitz B, Bock C, Kerskens CM, Hoehn-Berlage M] Book Chapter, 1996

Kerskens, CM, HoehnBerlage, M, Schmitz, B, Busch, E, Bock, C, Gyngell, ML, AlexanderHossmann, K, Ultrafast perfusion-weighted MRI of functional brain activation in rats during forepaw stimulation: Comparison with T*(2)-weighted MRI, NMR IN BIOMEDICINE, 9, 1996 Journal Article, 1996

Bock C, Schmitz B, Kerskens CM, Gyngell ML, Hoehn-Berlage M, Hossmann K-A, Perfusion- und T2*-weighted imaging of functional activation in rat: Upregulation by transient hypercapnia, International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, April 27-May 3, 1996, 1996 Conference Paper, 1996

Kerskens CM, Hoehn-Berlage M, Schmitz B, Busch E, Bock C, Gyngell ML, Hossmann K-A, Fast perfusion measurement of functional activation of rat brain during forepaw stimulation: comparison with T2*-fMRI, laser-doppler flow measurement and 14C-iodoantipyrine autoradiography, International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, April 27-May 3, 1996, 1996 Conference Paper, 1996

Kerskens CM, Hoehn-Berlage M, Schmitz B, Busch E, Bock C, Gyngell ML, Hossmann K-A, Ultrafast perfusion-weighted MRI of functional brain activation in rats during forepaw stimulation: comparison with T2*-weighted MRI, NMR in Biomedicine, 8, 1996, p20-23 Journal Article, 1996

Allegrini PR, Hoehn-Berlage M, Busch E, Krueger K, Kerskens CM, NMR imaging observation of rat brain perfusion changes during stroke: interpretation based on combination with physiological parameters, International Society for Magnetic Resonance in Medicine, 4th scientific meeting and exhibition, New York, April 27-May 3, 1996 Conference Paper, 1996

Wiedenhover I, Kerskens C, Eschenauer M, Albers S, v. Brentano P, Analogous negative-parity spectra of Xe-125 and Xe-127, Zeitschrift fuer Physik A-Hadrons and Nuclei, 350, (4), 1995, p287 - 288 Journal Article, 1995

Wiedenhover I, Neuneyer U, Kerskens C, Altmann J, Stuch O, Theuerkauf J, Siems G, Wirowski R, Eschenauer M, v. Brentano P, Schubart R, Kluge H, Maier KH., High-spin structure in Xe-127 and Xe-125, Zeitschrift fuer Physik A-Hadrons and Nuclei, 347 (1), 1993, p71 - 72 Journal Article, 1993

Non-Peer-Reviewed Publications

Blau C, Kelly L, Kerskens C, Lynch M, The age-related increase in microglial activation in rat brain is coupled with a decrease in blood flow as measured by MRI, MNIEST conference, UCD Dublin, march 2008, 2008 Meeting Abstract, 2008

Kelly ME, Blau CW, Kerskens CM, Bolus-tracking arterial spin labelling - theoretical and experimental results, 17th Annual NMR Symposium, Sheffield, UK, March 31st 2008, 2008 Meeting Abstract, 2008

Flamini V,Kerskens C, Lally C, Study of the 3D fibre distribution through A Porcine Aorta using diffusion tensor imaging, Sir Barnard Crossland symposium, 2008, 2008 Conference Paper, 2008

Döge C, Kerskens CM, Romero BI, Brunecker P, v. Pannwitz W, Junge-Hülsing J, Müller B, Villringer A, . Infarct evolution differs between gray and white matter: a MRI study, 9th European Stroke Conference, Vienna, Austria, May 24-27, 2000, 2000 Conference Paper, 2000

Schmitz B, Bock C, Kerskens CM, Hoehn-Berlage M, Boettiger BW, Hossmann K-A, Nicht-invasives Monitoring der funktionellen Erholung des Gehirns nach Herz-Kreislaufstillstand mittels funktioneller NMR-Bildgebung, Wissenschaftliche Arbeitstage der deutschen Gesellschaft der Anaesthesisten, Wuerzburg, Germany, 23. -24. Februar, 1996, 1996 Conference Paper, 1996

Schmitz B, Bock C, Kerskens CM, Hoehn-Berlage M, Boettiger BW, Hossmann K-A, Funktionelle NMR-Bildgebung zur Untersuchung der Erholung des Gehirns nach Herz-Kreislaufstillstand und Reanimation im Tiermodell, Deutscher Anaesthesiekongreß (DAK), Nuernberg, Germany, 19. - 22. Juni, 1996, 1996 Conference Paper, 1996

Research Expertise

Description

. Extra vascular transport mechanisms . Quantification of cerebral blood flow . Neurovascular coupling . Physiological noise in the brain . Time series analysis of MRI data . Direct detection of cell activation with NMR . NMR relaxation mechanisms in biological tissue . Intra and extra cellular diffusion . Technical development for living science research

Projects

  • Title
    • Development of new cerebral perfusion biomarkers
  • Funding Agency
    • SFI
  • Date From
    • 09-2011
  • Date To
    • 09-2015

Keywords

Physics

Recognition

Memberships

Deutsche Physikalische Gesellschaft, Germany