James O'Donnell
Clinical Senior lecturer, Haematology

Publications and Further Research Outputs

Peer-Reviewed Publications

Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins DR, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased thrombin generation potential in symptomatic versus asymptomatic moderate or severe carotid stenosis and relationship with cerebral microemboli., Journal of Neurology, Neurosurgery, and Psychiatry, 86, 2015, p460-467 Journal Article, 2015 DOI

Matino D, Lillicrap D, Astermark J, Dolan G, Kessler C, Lambert T, Makris M, O'Donnell JS, Pipe S, Santagostino E, Saint-Remy, Iorio A., Switching clotting factor concentrates: Considerations in estimating the risk of immunogenicity., Haemophilia, 20, (2), 2014, p200 - 206 Journal Article, 2014

Gleason E, O'Donnell JS, Hams E, Fallon PF, Preston RJ. , Activated Factor X Inhibits Leukocyte Pro-inflammatory Cytokine Release upon Toll-like Receptor Stimulation. , Haematologica, 99, (1), 2014, p185 - 193 Journal Article, 2014

Tobin WO, Kinsella JA, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Egan B, Feeley TM, Coughlan T, Collins DR, Harbison JA, McCabe DJH, Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke., Journal of Neurology, 261, (7), 2014, p1405 - 1412 Journal Article, 2014

Kinsella JA, Tobin WO, Kavanagh GF, O'Donnell JS, McGrath RT, Tierney S, Feeley TM, Egan B, O'Neill D, Collins RD, Coughlan T, Harbison JA, Doherty CP, Madhavan P, Moore DJ, O'Neill SM, Colgan MP, Saqqur M, Murphy RP, Moran N, Hamilton G, McCabe DJ, Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups., European Journal of Neurology, 2014, p460-467 Journal Article, 2014 TARA - Full Text DOI

Laffan M, Lester W, O'Donnell JS, Will A, Tait RC, Goodeve A, Millar CM, Keeling D , Diagnosis and management of von Willebrand disease: A United Kingdom Haemophilia Centre Doctors Organisation guideline approved by the British Committee for Standards in Haematology., British Journal of Haematology, 2014 Journal Article, 2014

McGrath RT, van den Biggelaar M, Byrne B, O'Sullivan JM, Rawley O, O'Kennedy R, Voorberg J, Preston RJ, O'Donnell JS. , Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. , Blood, 122, (25), 2013, p4107 - 4110 Journal Article, 2013

Berntorp E, Fuchs B, Makris M, Montgomery RR, Flood VH, O'Donnell JS, Federici A, Lillicrap D, James P, Budde U, Morfini M, Petrini P, Austin S, Kannicht C, Lee C. , Third Åland island conference on von Willebrand disease, Haemophilia, (Supp 3), 2013, p1 - 18 Journal Article, 2013

Tobin WO, Kinsella JA, Kavanagh GF, O'Donnell JS, McGrath RA, Collins DR, Coughlan T, O'Neill D, Egan B, Tierney S, Feeley TM, Murphy RP, McCabe DJ, Longitudinal assessment of thrombin generation potential in response to alteration of antiplatelet therapy after TIA or ischaemic stroke., Journal of Neurology, 260, (2), 2013, p590-6 Journal Article, 2013 DOI

Harris LF, Rainey P, Castro-López V, O'Donnell JS, Killard AJ. , A microfluidic anti-Factor Xa assay device for point-of-care monitoring of anticoagulation therapy. , Analyst, 138, (17), 2013, p4769 - 4776 Journal Article, 2013

Preston RJ, Rawley O, Gleeson EM, O'Donnell JS, Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities., Blood, 121, (19), 2013, p3801 - 3810 Journal Article, 2013

Tilley DO, Albert MA, Smolenski A, Cox D, O'Donnell JS, Douglas CW, Watson SP, Kerrigan SW., Glycoprotein Ib and FcRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis, Journal of Thrombosis and Haemostasis, 11, (5), 2013, p941 - 950 Journal Article, 2013

Jenkins PV, Keenan C, Keeney S, Cumming T, O'Donnell JS, Clinical utility gene card for: haemophilia B., European Journal of Human Genetics, 20, (5), 2012, p268 - 271 Journal Article, 2012

Ryan K, O'Donnell JS, Elevated plasma factor VIII levels in patients with venous thrombosis - Constitutional risk factor or secondary epiphenomenon?, Thrombosis Research, 129, (2), 2012, p105 - 106 Journal Article, 2012

Gleason EM, O'Donnell JS, Preston RJ. , The Endothelial Cell Protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. , Cellular and Molecular Life Sciences, 69, (5), 2012, p717 - 726 Journal Article, 2012

O'Donnell D, O'Connell N, O'Donnell JS, Einstein-PE study should not affect VTE therapy for cancer patients., New England Journal of Medicine, 366, (26), 2012, p2525- Journal Article, 2012

Jenkins PV, Rawley O, Smith OP, O'Donnell JS, Elevated factor VIII levels and risk of venous thromboembolism., British Journal of Haematology, 157, (6), 2012, p653 - 663 Journal Article, 2012

Castro-Lopez V, Harris LF, O'Donnell JS and Killard AJ, Comparative study of Factor Xa fluorogenic substrates and their influence on the quantification of LMWHs, Analytical and Bioanalytical Chemistry, 399, 2011, p691 - 700 Journal Article, 2011

Ni Ainle F*, O'Donnell JS* (joint first author), Johnson J, Gleeson E, Smith OP, Preston RJ. , Activated protein C N-linked glycans regulate cytoprotective signalling on endothelial cells, Journal of Biological Chemistry, 286, (2), 2011, p1323 - 1330 Journal Article, 2011

Vanessa Castro-Lopez, Leanne F. Harris, James S. O'Donnell, Anthony J. Killard, Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays, Journal of Pharmaceutical and Biomedical Analysis, 56, (5), 2011, p992-997 Journal Article, 2011 TARA - Full Text

Castro-López V, Murray B, Harris LF, O'Donnell JS, Killard AJ, Effects of four commercially available factor Xa proteins on the fluorogenic anti-factor Xa assay when monitoring unfractionated heparin., Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis, 2011 Journal Article, 2011 DOI

Harris LF, O'Brien A, Castro-López V, O'Donnell JS, Killard AJ. , Comparison of the anticoagulant response of a novel fluorogenic anti-FXa assay with two commercial anti-FXa chromogenic assays., Thrombosis Research, , 128, (6), 2011, p125 - 129 Journal Article, 2011

Harris LF, Castro-López V, Jenkins PV, O'Donnell JS, Killard AJ. , Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas., Thrombosis Research, 128, (6), 2011, p166 - 170 Journal Article, 2011

Harris LF, Castro-López V, Jenkins PV, O'Donnell JS, Killard AJ. , Comparison of a fluorogenic anti-FXa assay with a central laboratory chromogenic anti-FXa assay for measuring LMWH activity in patient plasmas., Thrombosis Research, 128, (6), 2011, p166 - 170 Journal Article, 2011

Cumming AM, Keeney S, Jenkins PV, Nash MJ, O'Donnell JS, Clinical utility gene card for: von Willebrand disease, European Journal of Human Genetics, Jan 5, 2011, pEpub- Journal Article, 2011

Keeney S, Cumming AM, Nash MJ, O'Donnell JS, Jenkins PV. , Clinical utility gene card for: Haemophilia A., European Journal of Human Genetics,, 19, (11), 2011, p107 - 111 Journal Article, 2011

Bacon CL, Singleton E, Brady B, White B, Nolan B, Gilmore R, O'Donnell JS. , Low risk of inhibitor formation in haemophilia A patients following an en masse switch in treatment to a third generation full length recombinant FVIII product. , Haemophilia, 17, (3), 2011, p407 - 411 Journal Article, 2011

Harris L, Castro-López V, Hammadi N, O'Donnell JS, Killard AJ, The development of a fluorescent anti-factor Xa (FXa) assay and its application to the monitoring of a range of heparin-like anticoagulants, Talanta, 81, (4-5), 2010, p1725 - 1730 Journal Article, 2010

Sherlock E, O'Donnell JS, White B, Blake C , Physical activity levels and participation in sport in Irish people with haemophilia, Haemophilia, 16, (1), 2010, pe202 - e209 Journal Article, 2010

Bridges DJ, Bunn J, van Mourik J, Preston RJ, Molyneux M, Combes V, O'Donnell JS, de Laat B, Craig A. , Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings, Blood, 115, (7), 2010, p1472 - 1474 Journal Article, 2010

Terraube V, O'Donnell JS, Jenkins PV, Factor VIII and von Willebrand interactions - biochemical basis and physiological significance, Haemophilia, 16, (1), 2010, p3 - 13 Journal Article, 2010

Gilmore R, Harmon S, Gannon C, O'Donnell JS, Jenkins PV, Thrombin generation in haemophilia A patients with factor VIII assay discrepancy, Haemophilia, 16, (4), 2010, p671 - 674 Journal Article, 2010

Byrne M, Reynolds JV, O'Donnell JS, Keogan M, White B, Murphy S, Maher S, Pidgeon G, Activation of the procoagulant response following neoadjuvant chemotherapy and radiation therapy, and long-term activation following major cancer surgery, British Journal of Cancer, 102, (1), 2010, p73 - 79 Journal Article, 2010

McLean S, Ryan M, O'Donnell JS, Role of primary thromboprophylaxis in the palliative care setting - a systematic review, Palliative Medicine, 24, (4), 2010, p386 - 395 Journal Article, 2010

Byrne M, Reynolds JV, O'Donnell JS, Keogan M, White B, Byrne M, Murphy S, Maher SG, Pidgeon GP, Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery., British Journal of Cancer, 102, (1), 2010, p73-9 Journal Article, 2010 TARA - Full Text DOI

McGrath R, McKinnon TA, Byrne B, O'Kennedy R, McRae E, Preston RJ, O'Donnell JS, Terminal 2-6 linked sialic acid expression determines VWF proteolysis by ADAMTS13, Blood, 115, (13), 2010, p2666 - 2673 Journal Article, 2010

McGrath R, McRae E, Smith OP, O'Donnell JS, Platelet VWF - structure, function and biological significance, British Journal of Haematology, 148, (6), 2010, p834 - 843 Journal Article, 2010

Larkin, D, de Laat, B, Jenkins, PV, Bunn, J, Craig, AG, Terraube, V, Preston, RJ, Donkor, C, Grau, GE, van Mourik, JA, O'Donnell, JS, Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition., PLoS Pathogens, 5, (3), 2009, p1 - 8 Journal Article, 2009 TARA - Full Text DOI

Gilmore R, Harmon S, Keane G, Gannon C and O'Donnell JS , Variation in anticoagulant composition regulates differential effects of prothrombin complex concentrates on TF-initiated thrombin generation, Journal Thrombosis Haemostasis, 7, (12), 2009, p2154 - 2156 Journal Article, 2009

Preston RJ, Morse, Cutler, Murden, Brady SK, O'Donnell JS, Mumford AD. , Pseudo-homozygous protein C deficiency due to co-inheritance of novel type I and type IIb protein C variants., British Journal of Haematology, 144, (6), 2009, p946 - 953 Journal Article, 2009

Cunningham MS, Preston RJ, and O'Donnell JS. , Does antithrombotic therapy improve survival in cancer patients?, Blood Reviews, 23, 2009, p129 - 135 Journal Article, 2009

Ni Ainle F, Preston RJ, Jenkins PV, Johnson JS, Nell H, Fallon PG, White B, O'Donnell JS. , Protamine sulphate downregulates thrombin generation by inhibiting factor V activation, Blood, 114, (8), 2009, p1658 - 1665 Journal Article, 2009

Preston, RJ, Tran, S, Johnson, JA, Ainle, FN, Harmon, S, White, B, Smith, OP, Jenkins, PV, Dahlbäck, B, O'Donnell, JS, Platelet factor 4 impairs the anticoagulant activity of activated protein C., The Journal of Biological Chemistry, 284, (9), 2009, p5869 - 5875 Journal Article, 2009 TARA - Full Text DOI

Harmon, S, Preston, RJ, Ainle, FN, Johnson, JA, Cunningham, MS, Smith, OP, White, B, O'Donnell, JS, Dissociation of activated protein C functions by elimination of protein S cofactor enhancement., The Journal of Biological Chemistry, 283, (45), 2008, p30531 - 30539 Journal Article, 2008 TARA - Full Text DOI

Cunningham SM, Gilmore R, O'Donnell D, O'Donnell JS., Management of refractory venous thrombosis associated with malignancy using a supra-therapeutic Enoxaparin regimen. , Irish Journal of Medical Science,, 1, 2008, pe1 - e3 Journal Article, 2008

Gilmore R, Doyle M, Holden F and O'Donnell J, Activated protein C resistance, factor V Leiden and assessment of thrombotic risk, Irish Medical Journal, 101, (8), 2008, p256 - 257 Journal Article, 2008

Ní Áinle F, Wong A, Appleby N, Byrne B, O Sullivan A, White B, O'Donnell J. , Efficacy and safety of once daily low molecular weight heparin (Tinzaparin sodium) in high risk pregnancy., Blood Coagulation and Fibrinolysis,, 19, 2008, p689 - 692 Journal Article, 2008

Winter PC, Egan H, McNulty O, Jones FG, O'Donnell J, Jenkins PV, Recurrent F8 Mutation in Irish Haemophilia A Patients: Evidence for a Founder Effect., Haemophilia, 14, 2008, p394 - 395 Journal Article, 2008

Jenkins PV, Egan H, Keenan C, Mellars G; O'Shea E, Nolan B, White B, O'Donnell J., Factor IX mutations and Haemophilia B in the Irish Population: Distinct genetic mechanisms for severe and mild haemophilia B., Haemophilia , 14, 2008, p717 - 722 Journal Article, 2008

Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O'Donnell JS, Concentration-dependent roles for heparin in modifying LPS-induced activation of mononuclear cells in whole blood., Thrombosis and Haemostasis, 99, 2008, p570 - 575 Journal Article, 2008

Loscertales MP, Owens S, O'Donnell JS, Bunn J, Brabin BJ., ABO blood group phenotypes and falciparum malaria: unlocking a pivotal mechanism., Advances in Parasitology, 65, 2007, p1 - 50 Journal Article, 2007

Hollestelle MKJ, Donkor C, Mantey E, Craig A, Akoto J, O'Donnell J, van Mourik J, Bunn J. , Von Willebrand factor propeptide in severe malaria: evidence of acute endothelial cell activation. , British Journal of Haematology, 133, 2006, p562 - 569 Journal Article, 2006

O'Donnell JS, Hinkson L, McCarthy A, Manning R, Khan A, and Lafffan MA, Antithrombin Nagasaki (Ser 116 to Pro): a rare antithrombin variant with abnormal heparin binding presenting during pregnancy., Blood Coagulation and Fibrinolysis, 17, 2006, p217 - 220 Journal Article, 2006

Cunningham SE, White B, Hollywood D, and O'Donnell JS., Primary thromboprophylaxis for cancer patients with central venous catheters - a reappraisal of the evidence., British Journal of Cancer, 94, 2006, p189 - 194 Journal Article, 2006

Cunningham SE, White B, and O'Donnell JS., Prevention and management of venous thrombo-embolism in patients with cancer - a review of the evidence., Clinical Oncology, 1, 2006, p145 - 151 Journal Article, 2006

Jenkins PV and O'Donnell JS., ABO blood group determines plasma von Willebrand factor levels - a biological function after all?, Transfusion, 46, 2006, p1836 - 1844 Journal Article, 2006

Crawley JTB, Lam JK, Rance JB, Mollica LR, O'Donnell JS and Lane DA., Proteolytic Regulation of ADAMTS-13: Novel Roles for Thrombin and Plasmin., Blood, 105, 2005, p1085 - 1093 Journal Article, 2005

O'Donnell JS., Severe factor V deficiency and pregnancy - a role for solvent-detergent plasma? , Haemophilia, 11, 2005, p422 - 423 Journal Article, 2005

O'Donnell JS, McKinnon TAJ, Crawley JTB, Lane DA and Laffan MA., Bombay phenotype is associated with reduced plasma VWF levels and an increased susceptibility to ADAMTS13 proteolysis., Blood, 106, 2005, p1988 - 1991 Journal Article, 2005

O'Donnell J. , Prevention of hospital acquired venous thromboembolism., British Medical Journal Learning., 1, 2005, p1 - 5 Journal Article, 2005

Cunningham N, Laffan MA, Manning RA and O'Donnell J. , Role of Low-Density Lipoprotein Receptor-Related Protein (LRP) in Patients with Elevated FVIII:C and Venous Thrombosis., Blood Coagulation and Fibrinolysis, , 16, 2005, p465 - 468 Journal Article, 2005

Baguley C, Guri S, O'Donnell J, and Howard D., Consumptive coagulopathy complicating juvenile angiofibroma. , Journal of Laryngology and Otology,, 118, 2004, p835 - 839 Journal Article, 2004

O'Donnell J, Riddell A, Owens D, Pasi KJ and Perry DJ., Role of the Thromboelastograph as an adjunctive test in thrombophilia screening., Blood Coagulation and Fibrinolysis , 15, 2004, p207 - 211 Journal Article, 2004

O'Connell MP, Murphy KM, White B and O'Donnell J., Solvent-detergent plasma as replacement therapy in a pregnant patient with factor V deficiency., Journal of Maternal Fetal and Neonatal Medicine, 16, 2004, p69 - 70 Journal Article, 2004

O'Donnell J, Manning RA, and Laffan M., Beta-adrenergic receptor polymorphisms in patients with elevated FVIII levels with venous thrombosis., British Journal of Haematology, 123, 2003, p139 - 141 Journal Article, 2003

Doyle S, O'Brien P, Murphy K, and O'Donnell J. , Coagulation factor content of solvent / detergent plasma compared to fresh frozen plasma., Blood Coagulation and Fibrinolysis, 14, 2003, p283 - 287 Journal Article, 2003

O'Donnell J, and Laffan M. , Dissociation of ABH antigen expression from von Willebrand factor synthesis in endothelial cell lines., British Journal of Haematology , 121, 2003, p928 - 931 Journal Article, 2003

O'Brien P, Murphy K, and O'Donnell J. , Acquired protein S deficiency in TTP patients receiving solvent / detergent plasma exchange. , British Journal of Haematology, 122, 2003, p518 - 519 Journal Article, 2003

O'Donnell J, Boulton FE, Manning RA, and Laffan M., Genotype at the Secretor blood group locus is a determinant of plasma von Willebrand factor level., British Journal of Haematology, 116, 2002, p350 - 356 Journal Article, 2002

O'Donnell J and Perry DJ., Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia., Expert Opinion on Pharmacotherapy, 3, 2002, p1591 - 1598 Journal Article, 2002

O'Donnell J, Manning RA and Laffan M., The relationship between plasma concentration of a2-macroglobulin and ABO blood group., Thrombosis and Haemostasis, 88, 2002, p167 - 168 Journal Article, 2002

Mumford AD, Laffan MA, O'Donnell J, McVey JH, Manning RA, and Kemball-Cook G., A Tyr346Cys substitution in the inter-domain acidic region a1 of Factor VIII in an individual with Factor VIII:C assay discrepancy. , British Journal of Haematology, 118, 2002, p589 - 594 Journal Article, 2002

O'Donnell J, Boulton FE, Manning RA, and Laffan M., The amount of H antigen expressed on circulating vWF is modified by ABO blood group genotype and is a major determinant of plasma vWF:Ag levels. , Arteriosclerosis, Thrombosis and Vascular Biology, 22, 2002, p335 - 341 Journal Article, 2002

O'Donnell J and Laffan M, The relationship between ABO histo-blood group, factor VIII and von Willebrand factor. , Transfusion Medicine, 11, 2001, p1 - 10 Journal Article, 2001

O'Donnell J, Mumford AD, Manning RA and Laffan MA. , Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism., British Journal of Haematology, 115, 2001, p687 - 697 Journal Article, 2001

O'Donnell J and Laffan M, Elevated plasma factor VIII:C - a novel independent risk factor for venous thromboembolism. , Clinical Laboratory , 47, 2001, p1 - 6 Journal Article, 2001

O'Donnell J, Mille-Baker B and Laffan M, Human umbilical vein endothelial cells differ from other endothelial cells in failing to express ABO blood group antigens., Journal of Vascular Research, 37, 2000, p540 - 547 Journal Article, 2000

O'Donnell J, Mumford AD, Manning RA and Laffan M. , Elevation of FVIII:C in venous thromboembolism is persistent and independent of the acute phase response., Thrombosis and Haemostasis, 83, 2000, p10 - 13 Journal Article, 2000

Mumford A, O'Donnell J, Gillmore J, Manning R, and Laffan M. , Bleeding symptoms and coagulation test abnormalities in 337 patients with AL amyloidosis., British Journal of Haematology, 110, 2000, p454 - 460 Journal Article, 2000

O'Donnell J and Laffan M, Factor VIII and thrombosis, CME Bulletin Haematology, 2, 1999, p44 - 46 Journal Article, 1999

O'Donnell J, Goldman JM, Wagner K, Ehinger G, and Roberts I. , Donor-derived plasmodium vivax infection following volunteer unrelated bone marrow transplantation., Bone Marrow Transplantation, (21), 1998, p313 - 314 Journal Article, 1998

O'Donnell J, Tuddenham E, Manning R, Kemball-Cook G, and Laffan M. , High prevalence of elevated Factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction., Thrombosis and Haemostasis, 77, 1997, p825 - 828 Journal Article, 1997

O'Donnell J, Roberts I, Daly P, New H and Dokal I., Successful second bone marrow transplant for Fanconi's anaemia following escalation of conditioning., British Journal of Haematology, 98, 1997, p772 - 774 Journal Article, 1997

Research Expertise

Keywords

Biomedical Research Training; Bleeding Disorders; Blood Diseases; Cardiovascular Diseases; Hematology; Hemophilia; Pregnancy Disorders; Thrombosis; von Willebrand's Disease

Recognition

Awards and Honours

MRC Clinical Training Fellowship Award 1997

Race Sanger Award - British Blood Transfusion Society 2002

BHF Intermediate Fellowship Award 2003

SFI President of Ireland Researcher Award 2006

Memberships

International Society for Thrombosis and Haemostasis 2002 – present

American Society for Hematology 2001 – present

British Society of Haematology 2001 – present

British Society for Haemostasis and Thrombosis 2004 – present

Irish Haematology Association 2005 – present