Steven Gray
Adjunct Assistant Professor, Molecular Medicine Ireland
Adjunct Assistant Professor, Clinical Medicine

Biography

Steven Gray graduated from Trinity College Dublin in 1992. He joined the laboratory of Tomas J. Ekstrom at the Karolinska Institute in 1996 and received his PhD in 2000 (Thesis Title: The IGF-axis in liver disease: Modulation of expression by histone deacetylase inhibitors). He moved to the Van Andel Research Institute in Michigan, USA where he continued his studies on the therapeutic potential of histone deacetylase inhibitors in the treatment of cancer. He also spent some time as a visting fellow at Harvard Medical School, Boston working on epigenetic therapies for neurodegenerative disease. Returning to Europe Dr Gray spent some time at the German Cancer Research Centre (DKFZ - Heidelberg), and subsequently moved to Copenhagen to work for Novo Nordisk as part of the research team of Prof Pierre De Meyts at the Hagedorn Research Institute working on epigenetic mechanisms underpinning diabetes pathogenesis. Dr Gray is currently a senior clinical scientist at St James's Hospital in the Deprtment of Clinical Oncology at the Thoraacic Oncology Research Group at St. James's Hospital headed by Dr. Sinead Cuffe and Professor Stephen Finn, and holds an adjunct assistant professorship with the Dept of Clinical Medicine (TCD).

Publications and Further Research Outputs

Peer-Reviewed Publications

MacDonagh L, Gray SG, Breen E, Cuffe S, Finn SP, O'Byrne KJ, Barr MP, Lung cancer stem cells: The root of resistance., Cancer letters, 372, (2), 2016, p147-56 Journal Article, 2016 DOI

Joerger, M., Finn, S.P., Cuffe, S., Byrne, A.T., Gray, S.G., The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?, Expert Opinion on Therapeutic Targets, 20, (11), 2016, 1339-1356 Journal Article, 2016 DOI

Cregan S, McDonagh L, Gao Y, Barr MP, O'Byrne KJ, Finn SP, Cuffe S, Gray SG, KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma., International journal of oncology, 48, (3), 2016, p1290-6 Journal Article, 2016 DOI

Baird AM, Gray SG, Richard DJ, O'Byrne KJ, Promotion of a cancer-like phenotype, through chronic exposure to inflammatory cytokines and hypoxia in a bronchial epithelial cell line model., Scientific reports, 6, 2016, p18907 Journal Article, 2016 DOI TARA - Full Text

Gray, S.G., Cuffe, S., Finn, S.P., PD-L1 as a companion biomarker for immune checkpoint inhibitors in NSCLC: Should RNA ISH (RISH) be considered?, Journal of Thoracic Oncology, 11, (11), 2016, e142-e144 Journal Article, 2016 DOI

MacDonagh,Lauren , Gray,Steven George, Finn,Stephen P. , Cuffe,Sinead D. , O'Byrne,Kenneth John, Barr,Martin P. , The emerging role of microRNAs in resistance to lung cancer treatments, Cancer Treatment Reviews, 41, (2), 2015, p160-169 Journal Article, 2015 DOI

Chapter 9. Epigenetic Therapy in Lung Cancer and Mesothelioma in, editor(s)Steven G. Gray , Epigenetic Cancer Therapy, 1st Edition. , Academic Press, 2015, pp189 - 213, [Anne-Marie Baird, Derek Richard, Kenneth J. O'Byrne, Steven G. Gray] Book Chapter, 2015

Chapter 26. Epigenetics of Cisplatin Resistance. in, editor(s)Stevn G. Gray , Epigenetic Cancer Therapy, 1st Edition. , Academic Press, 2015, pp613 - 637, [Steven G. Gray] Book Chapter, 2015

Quinn L, Finn SP, Cuffe S, Gray SG, Non-coding RNA repertoires in malignant pleural mesothelioma., Lung cancer (Amsterdam, Netherlands), 90, (3), 2015, p417-26 Journal Article, 2015

Perry AS, Baird AM, Gray SG, Epigenetic Methodologies for the Study of Celiac Disease., Methods in molecular biology (Clifton, N.J.), 1326, 2015, p131-58 Journal Article, 2015

Barr, M.P., Gray, S.G., Gately, K., (...), Pidgeon, G.P., O'Byrne, K.J., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer, Molecular Cancer, 14, (1), 2015, p45- Journal Article, 2015 DOI TARA - Full Text

Introduction in, editor(s)Steven G. Gray , Epigenetic Cancer Therapy, 1st Edition, Academic Press, 2015, pp1 - 6, [Steven G. Gray] Book Chapter, 2015

Gray,Steven George S.G., Epigenetic-based immune intervention for rheumatic diseases, Epigenomics, 6, (2), 2014, p253-271 Journal Article, 2014 DOI

Zhao, Jun , Greene, Catherine M. , Gray, Steven George , Lawless, Matthew William, Long noncoding RNAs in liver cancer: What we know in 2014, Expert Opinion on Therapeutic Targets, 18, (10), 2014, p1207-1218 Journal Article, 2014 DOI

Wright CM, Kirschner MB, Cheng YY, O'Byrne KJ, Gray SG, Schelch K, Hoda MA, Klebe S, McCaughan B, van Zandwijk N, Reid G, Long non coding RNAs (lncRNAs) are dysregulated in Malignant Pleural Mesothelioma (MPM)., PloS one, 8, (8), 2013, pe70940 Journal Article, 2013 DOI TARA - Full Text

Versteyhe S, Klaproth B, Borup R, Palsgaard J, Jensen M, Gray SG, De Meyts P, IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor., Frontiers in endocrinology, 4, 2013, p98 Journal Article, 2013

Baird AM, O'Byrne KJ, Gray SG, Epigenetic regulation of chemokine/chemokine receptor expression., Methods in molecular biology (Clifton, N.J.), 1013, 2013, p185-201 Journal Article, 2013 DOI

Gray,Steven George S.G., Perspectives on epigenetic-based immune intervention for rheumatic diseases, Arthritis Research and Therapy, 15, (2), 2013, p207 Journal Article, 2013 DOI

Baird AM, Leonard J, Naicker KM, Kilmartin L, O'Byrne KJ, Gray SG, IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer., Lung cancer (Amsterdam, Netherlands), 79, (1), 2013, p83-90 Journal Article, 2013 DOI

Manente AG, Valenti D, Pinton G, Jithesh PV, Daga A, Rossi L, Gray SG, O'Byrne KJ, Fennell DA, Vacca RA, Nilsson S, Mutti L, Moro L, Estrogen receptor ß activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo., Oncogenesis, 2, 2013, pe72 Journal Article, 2013 DOI

Barr MP, Gray SG, Hoffmann AC, Hilger RA, Thomale J, O'Flaherty JD, Fennell DA, Richard D, O'Leary JJ, O'Byrne KJ., Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature., PloS one, 8, (1), 2013, pe54193 Journal Article, 2013 TARA - Full Text URL DOI

Baird AM, Dockry E, Daly A, Stack E, Doherty DG, O'Byrne KJ, Gray SG, IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer., Frontiers in oncology, 3, 2013, p162- Journal Article, 2013 DOI TARA - Full Text

Allott EH, Oliver E, Lysaght J, Gray SG, Reynolds JV, Roche HM, Pidgeon GP, The SGBS cell strain as a model for the in vitro study of obesity and cancer., Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 14, (10), 2012, p774-82 Journal Article, 2012 DOI

Busacca S, Sheaff M, Arthur K, Gray SG, O'Byrne KJ, Richard DJ, Soltermann A, Opitz I, Pass H, Harkin DP, Quinn JE, Fennell DA, BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma., The Journal of pathology, 227, (2), 2012, p200-8 Journal Article, 2012

Gray SG, Baird AM, O'Kelly F, Nikolaidis G, Almgren M, Meunier A, Dockry E, Hollywood D, Ekström TJ, Perry AS, O'Byrne KJ, Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor., International journal of molecular medicine, 30, (6), 2012, p1505-11 Journal Article, 2012 DOI

Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus VC, Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression., PloS one, 7, (12), 2012, pe52753 Journal Article, 2012 TARA - Full Text DOI

Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB, Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent., European journal of cancer (Oxford, England : 1990), 48, (7), 2012, p1096-107 Journal Article, 2012

Baird, AM; Gray, SG; O'Byrne, KJ , Expression of the CXC (ELR plus ) receptor, CXCR2, is reactivated by epigenetic means in non-small cell lung cancer, Lung Cancer, 71, 2011 Journal Article, 2011

Baird AM, Gray SG, O'Byrne KJ, IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF., European journal of cancer (Oxford, England : 1990), 47, (12), 2011, p1908-18 Journal Article, 2011 DOI

Gray SG, Epigenetic treatment of neurological disease., Epigenomics, 3, (4), 2011, p431-50 Journal Article, 2011

Busacca, S., Gray, S.G., Paul, I., McTavish, N., O'Byrne, K.J., Quinn, J.E., and Fennell, D.A. , BRCA1 expression and efficacy of vinorelbine in malignant mesothelioma, Journal of Clinical Oncology, 29, 2011 Journal Article, 2011

Cathcart MC, Gray SG, Baird AM, Boyle E, Gately K, Kay E, Cummins R, Pidgeon GP, O'Byrne KJ, Prostacyclin synthase expression and epigenetic regulation in nonsmall cell lung cancer., Cancer, 117, (22), 2011, p5121-32 Journal Article, 2011 DOI

O'Byrne KJ, Barr MP, Gray SG., The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer, Cancers, 3, (1), 2011, p1426 - 1453 Journal Article, 2011 TARA - Full Text

Easty, D., Gray, S.G., Baird, A., Soltermann, A., Nonaka, D., Fennell, D.A., Opitz, I., Pass, H.I., Mutti, L., O'Donnell, D.M., and O'Byrne, K.J. , MST1R, a receptor tyrosine kinase expressed in malignant pleural mesothelioma, Journal of Clinical Oncology, 29, 2011 Journal Article, 2011

KJ O'Byrne, The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer, Cancers , 3, (1), 2011, p1426-1453 Journal Article, 2011 TARA - Full Text

Anne-Marie Baird, Steven G. Gray, Kenneth J. O'Byrne, Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer, PLoS One, 6, (1), 2011, pe14593 Journal Article, 2011 URL DOI TARA - Full Text

Gray, S.G., Easty, D., Baird, A., Soltermann, A., Nonaka, D., Fennell, D.A., Mutti, L., Pass, H.I., Opitz, I., O'Donnell, D., and O'Byrne, K.J. , The Macrophage Stimulating Protein (MSP)-RON/MST1R axis in malignant pleural mesothelioma, IASLC World Lung , Amsterdam, Netherlands , July 3-7, 2011, 2011 Conference Paper, 2011

Easty DJ, Gray SG, O'Byrne KJ, O'Donnell D, Bennett DC, Receptor tyrosine kinases and their activation in melanoma., Pigment Cell & Melanoma Research, 24, (3), 2011, p446-461 Journal Article, 2011 TARA - Full Text DOI

Kenneth J. O'Byrne ; Anne-Marie Baird ; Lisa Kilmartin ; Jennifer Leonard ; Calen Sacevich ; Steven G. Gray, Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer, Cancers , 3, (2), 2011, p1550-1565 Journal Article, 2011 TARA - Full Text

Krunic, D., Moshir, S., Greulich-Bode, K.M., Figueroa, R., Cerezo, A., Stammer, H., Stark, H.-J., (...), Boukamp, P., Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss , Biochimica et Biophysica Acta - Molecular Basis of Disease, 1792, (4), 2009, p297-308 Journal Article, 2009 DOI

Mahmood, S., Borup, R., Gray, S.G., and De Meyts, P., Gene expression profiling of human adipocyte responses to insulin and IGF-I signalling., The Open Diabetes Journal, 2, 2009, p5-17 Journal Article, 2009 DOI

Lawless, M. W., Norris, S., O'Byrne, K.J. and Gray, S.G., Histone Deacetylase inhibitors for the treatment of disease, Journal of Cellular and Molecular Medicine, 2009 Journal Article, 2009

Lawless, MW, Norris, S, O'Byrne, KJ, Gray, SG, Targeting histone deacetylases for the treatment of immune, endocrine & metabolic disorders., Endocrine, metabolic & Immune Disorders Drug Targets, 9, (1), 2009, p84-107 Journal Article, 2009 DOI

Histone deacetylase inhibitors as a therapeutic modality in multiple sclerosis in, editor(s)Dr. Serena Guiducci & Dr Moncef Zouali , The Epigenetics of Autoimmune Diseases, Wiley Press, 2009, pp403 - 432, [Gray, S.G.] Book Chapter, 2009

Gray, SG, Fennell, DA, Mutti, L, O'Byrne, KJ, In arrayed ranks: array technology in the study of mesothelioma., Journal of Thoracic Oncology : official publication of the International Association for the Study of Lung Cancer, 4, (3), 2009, p411-425 Journal Article, 2009 URL DOI

Gray, S.G., Crowe, J., Lawless, M.W., Hemochromatosis: As a conformational disorder , International Journal of Biochemistry and Cell Biology , 2009 Journal Article, 2009 DOI

Mankan, A.K., Lawless, M.W., Gray, S.G., Kelleher, D., McManus, R., NF-κB regulation: The nuclear response , Journal of Cellular and Molecular Medicine , 13, (4), 2009, p631-643 Journal Article, 2009 TARA - Full Text

Lawless, M., Norris, S., O'Byrne, K.J and Gray, S.G., Targeting epigenetic pathways in obesity and diabetes, Cellscience Reviews, 4, (3), 2008, p119-166 Journal Article, 2008 URL

Lawless, MW, Mankan, AK, Gray, SG, Norris, S, Endoplasmic reticulum stress--a double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicity., The international journal of biochemistry & cell biology, 40, (8), 2008, p1403-1414 Journal Article, 2008 DOI

Gray, SG, Al-Sarraf, N, Baird, AM, Gately, K, McGovern, E, O'Byrne, KJ, Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells., Clinical lung cancer, 9, (6), 2008, p367-374 Journal Article, 2008 DOI

Lawless, MW, Norris, S, O'Byrne, KJ, Gray, SG, "Targeting Histone Deacetylases for the treatment of disease", Journal of cellular and molecular medicine, 2008 Journal Article, 2008 DOI

Al-Sarraf, N, Reiff, JN, Hinrichsen, J, Mahmood, S, Teh, BT, McGovern, E, De Meyts, P, O'byrne, KJ, Gray, SG, DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma., International journal of cancer. Journal international du cancer, 121, (5), 2007, p992-998 Journal Article, 2007 DOI

Gray, SG, Dangond, F, Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis., Epigenetics : official journal of the DNA Methylation Society, 1, (2), 2006, p67-75 Journal Article, 2006 URL

Gray, S.G. , DMMC workshop: unravelling chromatin and the role of epigenetics in disease., Epigenetics : official journal of the DNA Methylation Society, 1, (4), 2006, p187-189 Journal Article, 2006

Villanueva, R., Iglesias, A., Camelo, S., Sanin, L.C. Gray, S.G. and Dangond, F. , Histone deacetylase 3 represses HTLV-1 tax transcription. , Oncology Reports, 16, (3), 2006, p581-585 Journal Article, 2006 URL

"Malignant pleural mesothelioma: clinical presentation, radiological evaluation and diagnosis" in, editor(s)Kenneth O'Byrne, Consultant Oncologist, Hope Directorate, St James's Hospital, Dublin, Ireland Valerie Rusch, Chief of the Thoracic Service Surgery, William G Cahan Chair, Memorial Sloan-Kettering Cancer Center, New York, USA , Malignant Pleural Mesothelioma , Great Clarendon Street, Oxford OX2 6DP, Oxford University Press, 2006, pp35 - 60, [Michael D. Peake, James Entwisle, and Steven Gray] Book Chapter, 2006 URL

Shaukat Mahmood, Steven G. Gray, Rehannah Borup, Martin Wabitsch, Hans E. Tornqvist, Pierre De Meyts, Gene expression profiling of adipocyte/preadipocyte responses to Insulin and IGF-I signalling, Systems Biology: Integrating Biology, Technology and Computation (C6), Taos, New Mexico, USA, 05/03/06 - 10/03/06, 2006 Poster, 2006

Gray, S.G., and Dangond, F. , Rationale for the Use of Histone Deacetylase Inhibitors as a Therapeutic Modality in Multiple Sclerosis, Epigenetics, 1, (2 I), 2006, p67-75 Journal Article, 2006 URL

Greulich-Bode, K.M., Moshir, S., Figueroa, R., Cerezo, A., Lindenmaier, H., Stark, H-J., Gray, S.G., Vang Nilsen, K., Hartschuh, W., and Boukamp, P. , Differential Regulation of Telomere Length and Telomerase Activity in Normal Skin Keratinocytes In Vivo and In Vitro, 2006 Journal Article, 2006

Gray, S.G. and De Meyts, P., Role of histone and transcription factor acetylation in diabetes pathogenesis, Diabetes and Metabolism Research and Reviews, 21, (5), 2005, p416 - 433 Journal Article, 2005 URL DOI

Camelo S, Iglesias AH, Hwang D, Due B, Ryu H, Smith K, Gray SG, Imitola J, Duran G, Assaf B, Langley B, Khoury SJ, Stephanopoulos G, De Girolami U, Ratan RR, Ferrante RJ, Dangond F, Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis., Journal of Neuroimmunology, 164, (1-2), 2005, p10 - 21 Journal Article, 2005 DOI

Takahashi, M., Gray, S.G., Yuhas, J., Qian, C-N., Kanayama, H., Kagawa, S., Teh, B.T., Altered expression of members of the IGF-axis in Renal Cell Carcinoma, International Journal of Oncology, 26, (4), 2005, p923 - 931 Journal Article, 2005

Gray S.G., Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F. , Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein., Journal of Biological Chemistry, 280, (31), 2005, p28507 - 28518 Journal Article, 2005 DOI

Gray, S.G., Qian, C-N., Furge, K., Guo, X. and Teh, B.T., Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines, International Journal of Oncology, 24, (4), 2004, p773 - 795 Journal Article, 2004

Histone Acetyltransferases and Histone Deacetylases in Gene Regulation and as Drug Targets in, editor(s)Vincent T. DeVita, Jr., M.D. Samuel Hellman, M.D. Steven A. Rosenberg, M.D., Ph.D. , Progress in Oncology, USA, Jones and Bartlett , 2004, pp99 - 128, [Gray, S.G.] Book Chapter, 2004

Gray, S.G. , Erratum: The Insulin-like Growth Factors and Insulin-signalling Systems: An Appealing Target for Breast Cancer Therapy (Hormone and Metabolic Research (2003) 35 (857-871)) , Hormone and Metabolic Research, 36, (1), 2004, p74 Journal Article, 2004 DOI

Svechnikova, I., Gray, S. G., Kundrotiene, J., Ponthan, F., Kogner, P. and Ekström, T. J., Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate, International Journal of Oncology, 22, 2003, p579 - 588 Journal Article, 2003

Takahashi, M., Yang, X. J., Sugimura, J., Backdahl, J., Tretiakova, M., Qian, C-N., Gray, S. G., Knapp, R., Anema, J., Kahnoski, R., Nicol, D., Vogelzang, N. J., Furge, K. A., Kanayama, H., Kagawa, S., Teh, B. T. , Molecular sub-classification of kidney cancers and the discovery of new diagnostic markers, Oncogene, 22, (43), 2003, p6810 - 6818 Journal Article, 2003 DOI

Gray, S.G., Mathiasen, I.S., and De Meyts, P.D, The Insulin-like Growth Factors and Insulin-signalling Systems: An Appealing Target for Breast Cancer Therapy?, Hormone and Metabolic Research, 35, (11-12), 2003, p857 - 871 Journal Article, 2003 DOI

Gray, S.G., Iglesias, A., Teh, B.T., and Dangond, F., Modulation of Splicing Events in Histone Deacetylase 3 by various Extracellular and Signal Transduction Pathways, Gene Expression, 11, (1), 2003, p13 - 21 Journal Article, 2003

Guo, X., Lui, W-O., Qian, C-N., Chen, J-D., Gray, S.G., Rhodes, D., Haab, B., Stanbridge, E., Wang, H., Hong, M-H., Min, H-Q., Larsson, C., and Teh, B.T., Identifying cancer-related genes in nasopharyngeal carcinoma cell lines using DNA and mRNA expression profiling analyses, International Journal of Oncology, 21, 2002, p1197 - 1204 Journal Article, 2002

von Horn, H., Hwa, V., Rosenfeld, R. G., Hall, K., Teh, B. T., Tally, M., Ekström, T.J., and Gray, S.G. , Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastomas, International Journal of Molecular Medicine, 9, (6), 2002, p645 - 649 Journal Article, 2002

Gray, S.G. and Ekström T. J., The Human Histone Deacetylase Family, Experimental Cell Research, 262, 2001, p75 - 83 Journal Article, 2001 DOI

Dangond, F., Henriksson, M., Zardo, G., Caiafa, P. Ekström, T.J.,and Gray, S.G., Differential expression of class I HDACs: roles of cell density and cell cycle, International Journal of Oncology, 19, (4), 2001, p773 - 777 Journal Article, 2001

von Horn, H., Tally, M., Hall, K., Ekström, T.J., and Gray, S.G., Expression levels of insulin-like growth factor binding proteins and insulin receptor isoforms in hepatoblastomas, Cancer Letters, 162, (2), 2001, p253 - 260 Journal Article, 2001 DOI

Eriksson, T., Frisk, T., Gray, S.G., von Schweinitz, D., Pietsch, T., Larsson, C., Sandstedt, B. and Ekström, T.J., Methylation Changes in the Human IGF2 P3 Promoter Parallel IGF2 Expression in the Primary Tumor, Established Cell Line, and Xenograft of a Human Hepatoblastoma , Experimental Cell Research, 270, (1), 2001, p88 - 95 Journal Article, 2001 DOI

Gray, S.G. and Teh, B. T., Histone Acetylation/Deacetylation and cancer: An "open" and "shut" case?, Current Molecular Medicine, 1, (4), 2001, p401 - 429 Journal Article, 2001 URL

Hartmann, W., Waha, A., Koch, A., Gray, S.G., Ekström, T.J., von Schweinitz, D., and Pietsch, T., Promoter-specific transcription of the IGF2 gene: a novel rapid, non-radioactive and highly sensitive protocol for mRNA analysis, Virchows Archiv, 439, 2001, p803 - 807 Journal Article, 2001 DOI

Gray, S.G., Guo, X., Kedra, D., Min, H-Q., and Teh, B.T., Correspondence re: P.P. Claudio et al., Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma, Cancer Research, 61, (15), 2001, p6950 - 6952 Journal Article, 2001 URL

Gray, S.G., Kytölä, S., Matsunaga, T., Larsson, C. and Ekström, T.J. , Comparative genomic hybridization reveals population based genetic alterations in hepatoblastomas, British Journal of Cancer, 83, 2000, p1020 - 1025 Journal Article, 2000

Gray, S.G., Eriksson, T., Ekström, C., Holm, S., Von Schweinitz, D., Kogner, P., Sandstedt, B., (...), Ekström, T.J. , Altered expression of members of the IGF-axis in hepatoblastomas, British Journal of Cancer , 82, (9), 2000, p1561-1567 Journal Article, 2000 DOI

Gray, S.G., Hartman, W., Kytölä, S., Eriksson, T., Ekström, C., von Schweinitz, D., Kogner, P., Sandstedt, B., Larsson, C., Pietsch, T., and Ekström, T.J., Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas, International Journal of Molecular Medicine, 6, 2000, p161 - 169 Journal Article, 2000

Gray, S.G., Kytölä, S., Weng O L., Larsson, C., and Ekström, T.J., Modulating IGFBP-3 expression by Trichostatin A: Potential therapeutic role in the treatment of Hepatocellular carcinoma, International Journal of Molecular Medicine, 5, (1), 2000, p33 - 41 Journal Article, 2000

Gray, S.G., Svechnikova, I., Hartmann, W., Aguilar-Santileses, M. and Ekström, T.J., IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with Trichostatin A, Cytokine, 12, (7), 2000, p1104 - 1109 Journal Article, 2000 DOI

Gray, S.G., Eriksson, E., and Ekström, T.J., Methylation, gene expression and the chromatin connection in cancer, International Journal of Molecular Medicine, 4, (4), 1999, p333 - 350 Journal Article, 1999 URL

Wang, Y., Rea, T., Bian, J., Gray, S., Sun, Y. , Identification of the genes responsive to etoposide-induced apoptosis: Application of DNA chip technology, FEBS Letters , 445, (2-3), 1999, p269-273 Journal Article, 1999 DOI

Gray, S.G., Yakovleva, T., Hartmann, W., Tally, M., Bakalkin, G., and Ekström, T.J., IGF-II enhances trichostatin A-induced TGFβ1 and p21(Waf1/Cip1/Sdi1) expression in Hep3B cells, Experimental Cell research, 253, (2), 1999, p618 - 628 Journal Article, 1999 DOI

Kjellman, M., Roshani, L., Teh, B.T., Kallioniemi, O-P., Höög, A., Gray, S., Farnebo, L-O., Holst, M., Bäckdahl, M., and Larsson, C., Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1 cM region in 2p16., The Journal of clinical endocrinology and metabolism, 84, (2), 1999, p730 - 735 Journal Article, 1999 DOI

Betz, R., Gray, S.G., Larsson, C., and Ekström, T. J. , Human Histone Deacetylase 2, HDAC2 (hRPD3), is located to 6q21 by Radiation Hybrid Mapping, Genomics, 52, 1998, p245 - 246 Journal Article, 1998

Gray, S.G., and Ekström, T. J., Effects of Cell Density and TrichostatinA on the Expression of HDAC1 and p57Kip2 in Hep 3B Cells, Biochemical and Biophysical Research Communications, 245, (2), 1998, p423 - 427 Journal Article, 1998 DOI

Li, X., Gray, S.G., Flam, F., Pietsch, T., and Ekström, T. J., Developmental-dependent DNA methylation of the IGF2 and H19 promoters is correlated to the promoter activities in human liver development, International Journal of Developmental Biology, 42, (5), 1998, p687 - 693 Journal Article, 1998 URL

Gray, S.G., Kjellman, M., Larsson, C., and Ekström, T. J., Novel splicing of an IGF2 polymorphic region in human adrenocortical carcinomas, Biochemical and Biophysical Research Communications, 239, (3), 1997, p878 - 883 Journal Article, 1997 DOI

Research Expertise

Description

My research mainly involves using epigenetic targeting agents to examine fundamental mechanisms underpinning the regulation of (i) Receptor Tyrosine Kinases (RTKs); (ii) inflammation and (iii) cellular metabolism in thoracic malignancy and to study their potential therapeutic efficacy in the treatment of lung cancer and mesothelioma. Research in my laboratory also tries to understand the role of epigenetics and epigenetic mechanisms underpinning drug resistance in lung cancer and mesothelioma. In addition to the above my research also involves the study of non-coding RNA repertoires (lncRNAs and circRNAs) in lung cancer and mesothelioma for their potential utility as candidate biomarkers for the early prediction of thoracic malignancy, and to study their roles in lung cancer biogenesis and resistance to therapy.

Keywords

CANCER; CANCER BIOPSIES; CANCER CELL-LINE; CANCER CELLS; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER DEVELOPMENT; CANCER INVASION; CANCER SUSCEPTIBILITY GENE; CANCER-CELLS; CANCERS; CARCINOMA; CARCINOMA CELL-LINES; CARCINOMA, RENAL CELL; CARCINOMA-CELLS; CARCINOMAS; CELL; Cellular Biology; CHROMATIN; Cloning of Cells; Cytogenetics; DNA MARKERS; DNA METHYLATION; EPIDERMAL GROWTH FACTOR RECEPTOR; Epigenetics; GENE EXPRESSION; GENE EXPRESSION ANALYSIS; GENE-EXPRESSION; Genetics; GENOME; Genomes, Genomics; GENOMICS; GROWTH FACTOR RECEPTOR; Histology; Histology, Cytochemistry, Histochemistry; HISTONE; HISTONE DEACETYLASE COMPLEX; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I AND II; Life Sciences; METASTASIS; Molecular Biology; Molecular Genetics; Systematic Biology; Tissue Culture; Transcription

Recognition

Representations

Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008-2010

Deputy Editor for the Epigenetic Regulators section of the Targeted Proteins database and Epigenetic Regulators section of the CBD Protein Systems journal (launched 2008) 2008 - present

Editorial Board Member The Open Diabetes Journal (Bentham http://www.bentham.org/open/todiaj/EBM.htm) from 2008 2008-2014

Founding Editorial Board Member "Clinical Epigenetics" 2009-present

Member of the Editorial Academy for the "International Journal of Oncology" https://www.spandidos-publications.com/pages/ijo/editorial 2016-present

Editorial Board member "World Journal of Experimental Medicine" (2011-2019) 2011-2019

Editorial Board member "Frontiers in Epigenomics" (Guest Associate Editor & Review Editor) http://www.frontiersin.org/Epigenomics

Editorial Board Member "Frontiers in Systems Physiology" (Review Editor, Systems Biology) http://www.frontiersin.org/systems_physiology

Editorial Board member World Journal of Biological Chemistry Dec 2013

Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008 to present

Grant Reviewer for: Australian National Health and Medical Research Council (NHMRC) (2010, 2012) Austrian Science Fund (2011) Bulgarian Science Foundation (2008) British Lung Foundation (2010) Cancer Research UK (2009) Czech Science Foundation (2012) Cyprus Research Promotion Foundation (2011) The Eli and Edythe Broad Foundation - Broad Medical Research Program (2012) Enterprise Ireland Commercialisation Fund (2005, 2006, 2008) Eureka Eurostars Technical Experts (2015-2016) Fondation contre le Cancer - Belgium (2016) Fondazione Pisa - Italy (2016) France's National Research Agency -ANR [Agence Nationale de la Recherche] (2008, 2011) German Research Foundation (2009) German-Israeli Foundation (2011) HRB Medical Charities Research Group (2008) IASLC (2011, 2012, 2013 on behalf of Professor Kenneth J. O'Byrne)

Grant Reviewer (2): INNOVATION FUND DENMARK (2015). Italian Telethon Foundation (2008) Multiple Sclerosis Society (UK) (2012) The Netherlands Organisation for Scientific Research (NWO) - VENI program (2013) National Science Centre Poland (OPUS) (2015) OeNB Anniversary Fund (Austria) (2014, 2015) OTKA - Hungarian Scientific Research Fund (2014, 2015) Prostate Cancer UK (2014) Wellcome Trust (2009) Swiss Cancer League (2010)

Ad Hoc Journal Reviewer for the following: Acta Neuropathologica, Aging, Antioxidants & Redox Signaling, BBA-Reviews on Cancer, BBA - Gene Regulatory Mechanisms, BMC Medical Genetics, BMC Urology, British Journal of Cancer, British Journal of Clinical Pharmacology, British Journal of Pharmacology, Cancer, Cancer Epidemiology, Cancers (MDPI), Cancer Research, Clinical and Experimental Rheumatology, Cell Biochemistry and Biophysics, Cellular & Molecular Life Sciences, CNS & Neurological Disorders-Drug Targets (CNSND-DT), Clinical Cancer Research, Clinical Lung Cancer, Cytokine, Diabetologia, E-Biomedicine, Epigenetics, European Journal of Cell Biology, European Journal of Pharmacology, Experimental Cell Research, Expert Opinion on Therapeutic Targets, Future Oncology - Epigenomics, Frontiers in Systems Biology, Genes & Cancer, Hormone & Metabolic Research, Inflammation & Allergy - Drug Targets, International Journal of Cancer, International Journal of Immunogenetics

Ad hoc reviewer for various journals (2): Irish Journal of Medical Science, Journal of Cellular & Molecular Medicine, Journal of Experimental and Molecular Pathology, The Journal of Pathology, Journal of Nucleic Acids, Journal of Thoracic Oncology, Life Sciences, Lung Cancer, Mini-Reviews in Medicinal Chemistry, Molecular Cancer Research, Molecular and Cancer Therapeutics, Neurogenetics, Neurological Research, Neuropsychiatric Disease and Treatment, the Open Diabetes Journal, Oncology Reports, OncoTarget, PLoS One, Pharmaceutical Patent Analyst, Pharmacological Research, Pharmacogenomics, Progress in Lipid Research, Translational Research, Trends in Neurosciences, Trends in Molecular Medicine

Invited "ad hoc" contributor to Trends in Genetics Short In Brief Articles section (2001-2002)

Independent Reporter for GenomeBiology (www.genomebiology.com) (2001)

Awards and Honours

Invited Speaker EFBIC Diabetes Workshop "Shifting paradigms in diabetes" February 26th 2009

Memberships

British Thoracic Oncology Group 2005 – present

iMiG (International Mesothelioma Interest Group)

ETOP (European Thoracic Oncology Program) - www.etop-eu.org

ToPCaP (Transdisciplinary Prostate Cancer Partnership) - http://topcapteam.org/