Ursula Fearon
Professor of Molecular Rheumatology, School Office - Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

McCarthy C, Orr C, Fee L, Dunlea DM, Hunt DJ, Dunne E, Carroll TP, O'Connell P, McCarthy G, Kenny D, Fearon U, Veale DJ, Reeves EP, McElvaney NG, Genetic variation of the alpha-1-antitrypsin gene is associated with increased autoantibody production in rheumatoid arthritis., 2017 Journal Article, 2017

Conway R, Fearon U, Molloy ES., Response to: ustekinumab inhibits Th1 and Th17 polarisation in a giant-cell arteritis patient by Samson et al., Annals of the rheumatic diseases, 2017 Journal Article, 2017 DOI

Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U, The role of metabolism in the pathogenesis of osteoarthritis., 2017 Journal Article, 2017

Orr C, Najm A, Biniecka M, McGarry T, Ng CT, Young F, Fearon U, Veale DJ., Synovial Immunophenotype and Anti-Citrullinated Protein Antibodies in RA patients: Relationship to treatment response and radiological prognosis., Arthritis & rheumatology (Hoboken, N.J.), 2017 Journal Article, 2017 DOI

Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells., J immunology, 198 , (2), 2017, p2249 - 2259 Journal Article, 2017 DOI

Veale DJ, Orr C, Fearon U., Cellular and molecular perspectives in rheumatoid arthritis., Seminars in immunopathology, 39, (4), 2017, p343-354 Journal Article, 2017 DOI

Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S., CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression., Journal of immunology (Baltimore, Md. : 1950), 198, (11), 2017, p4490-4501 Journal Article, 2017 DOI

McGarry T 1 , Biniecka M 1 , Gao W 1 , Cluxton D 2 , Canavan M 1 , Wade S 3 , Wade S 1 , Gallagher L 1 , Orr C 1 , Veale DJ 1 , Fearon U , Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis, Science Reports, 7, (22), 2017, p43165- Journal Article, 2017

Orr C, Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ., Synovial tissue research: a state-of-the-art review., Nature reviews. Rheumatology, 2017 Journal Article, 2017 DOI

McGarry T, Gao W, Veale DJ, Fearon U, Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis', Annals of Rheumatic Diseases, 8, 2017 Journal Article, 2017

Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A., Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells., Nature medicine, 2017 Journal Article, 2017 DOI

Gao W, McGarry T, Orr C, McCormick J, Veale DJ, Fearon U, Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors., 2016 Journal Article, 2016

Ademowo OS, Hernandez B, Collins E, Rooney C, Fearon U, van Kuijk AW, Tak PP, Gerlag DM, FitzGerald O, Pennington SR, Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis., 2016 Journal Article, 2016

Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI

Fearon U, Canavan M, Biniecka M, Veale DJ, Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis., 2016 Journal Article, 2016

Conway R, O'Neill L, O'Flynn E, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES, Ustekinumab for the treatment of refractory giant cell arteritis., 2016 Journal Article, 2016

Veale DJ, Fearon U, What makes psoriatic and rheumatoid arthritis so different?, 2015 Journal Article, 2015

Verheul MK, Fearon U, Trouw LA, Veale DJ, Biomarkers for rheumatoid and psoriatic arthritis., 2015 Journal Article, 2015

McGarry T, Veale DJ, Gao W, Orr C, Fearon U, Connolly M, Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis., 2015 Journal Article, 2015

Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G, Wright F, Akil M, Fearon U, Veale D, Ciani B, Wilson AG, C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis., 2015 Journal Article, 2015

Gao W, McCormick J, Connolly M, Balogh E, Veale DJ, Fearon U, Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis., 2015 Journal Article, 2015

Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM, Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity., Journal of immunology (Baltimore, Md. : 1950), 195, (2), 2015, p528-40 Journal Article, 2015 DOI

O'Neill L, Rooney P, Molloy D, Connolly M, McCormick J, McCarthy G, Veale DJ, Murphy CC, Fearon U, Molloy E, Regulation of Inflammation and Angiogenesis in Giant Cell Arteritis by Acute-Phase Serum Amyloid A., 2015 Journal Article, 2015

Collins ES, Butt AQ, Gibson DS, Dunn MJ, Fearon U, van Kuijk AW, Gerlag DM, Pontifex E, Veale DJ, Tak PP, FitzGerald O, Pennington SR, A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-" treatment of psoriatic arthritis., 2015 Journal Article, 2015

Connolly M, Rooney PR, McGarry T, Maratha AX, McCormick J, Miggin SM, Veale DJ, Fearon U, Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms., 2015 Journal Article, 2015

Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy E, Brayden D, Veale DJ, Fearon U, Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis., 2014 Journal Article, 2014

Fearon U, Veale DJ, Key Challenges in Rheumatic and Musculoskeletal Disease Translational Research., 2014 Journal Article, 2014

Strehl C, Fangradt M, Fearon U, Gaber T, Buttgereit F, Veale DJ, Hypoxia: how does the monocyte-macrophage system respond to changes in oxygen availability?, 2014 Journal Article, 2014

Rooney P, Connolly M, Gao W, McCormick J, Biniecka M, Sullivan O, Kirby B, Sweeney C, Molloy E, Markham T, Fearon U, Veale DJ, Notch-1 mediates endothelial cell activation and invasion in psoriasis., 2014 Journal Article, 2014

Mullan RH, Connolly M, Veale DJ, Fearon U, Is the serum amyloid A we use really serum amyloid A? Comment on the article by Connolly et al. Reply., 2013 Journal Article, 2013

Balogh E, Madruga Dias J, Orr C, Mullan R, Harty L, FitzGerald O, Gallagher P, Molloy M, O'Flynn E, Kelly A, Minnock P, O'Neill M, Moore L, Murray M, Fearon U, Veale DJ, Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder., 2013 Journal Article, 2013

Gao W, Sweeney C, Walsh C, Rooney P, McCormick J, Veale DJ, Fearon U, Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2., 2013 Journal Article, 2013

McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, Murphy EP, Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity., 2013 Journal Article, 2013

Connolly M, Rooney P, Gao W, Veale D, Fearon U, Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis., 2012 Journal Article, 2012

Yokota K, Miyazaki T, Hemmatazad H, Gay RE, Kolling C, Fearon U, Suzuki H, Mimura T, Gay S, Ospelt C, The pattern-recognition receptor nucleotide-binding oligomerization domain--containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts., 2012 Journal Article, 2012

Connolly M, Mullan RH, McCormick J, Matthews C, Sullivan O, Kennedy A, FitzGerald O, Poole AR, Bresnihan B, Veale DJ, Fearon U, Acute-phase serum amyloid A regulates tumor necrosis factor " and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy., 2012 Journal Article, 2012

Marzaioli V, McMorrow JP, Angerer H, Gilmore A, Crean D, Zocco D, Rooney P, Veale D, Fearon U, Gogarty M, McEvoy AN, Stradner MH, Murphy EP, Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes., 2012 Journal Article, 2012

Gao W, Sweeney C, Connolly M, Kennedy A, Ng CT, McCormick J, Veale DJ, Fearon U, Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis., 2012 Journal Article, 2012

Mix KS, McMahon K, McMorrow JP, Walkenhorst DE, Smyth AM, Petrella BL, Gogarty M, Fearon U, Veale D, Attur MG, Abramson SB, Murphy EP, Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription., 2012 Journal Article, 2012

Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, Appel H, Fearon U, Veale DJ, IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates., 2011 Journal Article, 2011

Pontifex EK, Gerlag DM, Gogarty M, Vinkenoog M, Gibbs A, Burgman I, Fearon U, Bresnihan B, Tak PP, Gibney RG, Veale DJ, FitzGerald O, Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study., 2011 Journal Article, 2011

Saber TP, Fearon U, Veale DJ, Is remission a more realistic goal in psoriatic arthritis?, 2011 Journal Article, 2011

Connolly M, Veale DJ, Fearon U, Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis., 2011 Journal Article, 2011

Kennedy A, Fearon U, Veale DJ, Godson C, Macrophages in synovial inflammation., 2011 Journal Article, 2011

Pontifex EK, Gerlag DM, Gogarty M, Vinkenoog M, Gibbs A, Burgman I, Fearon U, Bresnihan B, Tak PP, Gibney RG, Veale DJ, FitzGerald O, Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study., 2011 Journal Article, 2011

Saber T, Veale DJ, Balogh E, McCormick J, NicAnUltaigh S, Connolly M, Fearon U, Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis., 2011 Journal Article, 2011

Moran EM, Connolly M, Gao W, McCormick J, Fearon U, Veale DJ, Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement., 2011 Journal Article, 2011

van de Sande MG, Gerlag DM, Lodde BM, van Baarsen LG, Alivernini S, Codullo V, Felea I, Vieira-Sousa E, Fearon U, Reece R, Montecucco C, Veale DJ, Pitzalis C, Emery P, Klareskog L, McInnes IB, Tak PP, Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials., 2011 Journal Article, 2011

Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, Appel H, Fearon U, Veale DJ, IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates., 2011 Journal Article, 2011

van de Sande MG, Gerlag DM, Lodde BM, van Baarsen LG, Alivernini S, Codullo V, Felea I, Vieira-Sousa E, Fearon U, Reece R, Montecucco C, Veale DJ, Pitzalis C, Emery P, Klareskog L, McInnes IB, Tak PP, Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials., 2011 Journal Article, 2011

Fearon U, Interleukin-27: a master regulator in inflammation., 2011 Journal Article, 2011

Saber TP, Fearon U, Veale DJ, Is remission a more realistic goal in psoriatic arthritis?, 2011 Journal Article, 2011

Moran EM, Connolly M, Gao W, McCormick J, Fearon U, Veale DJ, Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement., 2011 Journal Article, 2011

Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U, A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A., 2010 Journal Article, 2010

Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U, A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A., 2010 Journal Article, 2010

Saber TP, Ng CT, Renard G, Lynch BM, Pontifex E, Walsh CA, Grier A, Molloy M, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Remission in psoriatic arthritis: is it possible and how can it be predicted?, 2010 Journal Article, 2010

Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U, Angiogenesis and blood vessel stability in inflammatory arthritis., 2010 Journal Article, 2010

Ng CT, Biniecka M, Kennedy A, McCormick J, Fitzgerald O, Bresnihan B, Buggy D, Taylor CT, O'Sullivan J, Fearon U, Veale DJ, Synovial tissue hypoxia and inflammation in vivo., 2010 Journal Article, 2010

Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U, Angiogenesis and blood vessel stability in inflammatory arthritis., 2010 Journal Article, 2010

Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O, Bresnihan B, Pitzalis C, Veale DJ, Fearon U, Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model., 2010 Journal Article, 2010

Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U, Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies., 2009 Journal Article, 2009

Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Gabalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP, Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers., 2009 Journal Article, 2009

Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U, Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies., 2009 Journal Article, 2009

Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Gabalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP, Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers., 2009 Journal Article, 2009

Oliver KM, Garvey JF, Ng CT, Veale DJ, Fearon U, Cummins EP, Taylor CT, Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway., 2009 Journal Article, 2009

O'Kane M, Markham T, McEvoy AN, Fearon U, Veale DJ, FitzGerald O, Kirby B, Murphy EP, Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition., 2008 Journal Article, 2008

Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin PJ, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F, Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse., 2008 Journal Article, 2008

Walsh CA, Fearon U, FitzGerald O, Veale DJ, Bresnihan B, Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy., 2008 Journal Article, 2008

Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin PJ, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F, Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse., 2008 Journal Article, 2008

O'Kane M, Markham T, McEvoy AN, Fearon U, Veale DJ, FitzGerald O, Kirby B, Murphy EP, Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition., 2008 Journal Article, 2008

Fearon U, Veale DJ, Angiogenesis in arthritis: methodological and analytical details., 2007 Journal Article, 2007

Fearon U, Veale DJ, Angiogenesis in arthritis: methodological and analytical details., 2007 Journal Article, 2007

Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ, Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy., 2007 Journal Article, 2007

Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, Wilson AG, Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis., 2007 Journal Article, 2007

Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'Hara R, FitzGerald O, Veale DJ, Fearon U, Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway., 2006 Journal Article, 2006

Veale DJ, Fearon U, Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting., 2006 Journal Article, 2006

Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ, Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures., 2006 Journal Article, 2006

Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'Hara R, FitzGerald O, Veale DJ, Fearon U, Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway., 2006 Journal Article, 2006

Veale DJ, Fearon U, Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting., 2006 Journal Article, 2006

Markham T, Mullan R, Golden-Mason L, Rogers S, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy., 2006 Journal Article, 2006

Markham T, Mathews C, Rogers S, Mullan R, Bresnihan B, Fitzgerald O, Veale DJ, Fearon U, Downregulation of the inhibitor of apoptosis protein survivin in keratinocytes and endothelial cells in psoriasis skin following infliximab therapy., 2006 Journal Article, 2006

Markham T, Mullan R, Golden-Mason L, Rogers S, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy., 2006 Journal Article, 2006

Leong TT, Fearon U, Veale DJ, Angiogenesis in psoriasis and psoriatic arthritis: clues to disease pathogenesis., 2005 Journal Article, 2005

Mullan R, Lobanok T, Walsh C, King L, FitzGerald O, Bresnihan B, Fearon U, Poole R, Veale D, The value of serum type II collagen epitope measurement in assessing early clinical response to treatment with anti-tumour necrosis factor alpha therapy in rheumatoid arthritis., 2005 Journal Article, 2005

Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia., 2005 Journal Article, 2005

Fearon U, Mullan R, Poole R, Markham T, FitzGerald O, Bresnihan B, Veale D, Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss., 2005 Journal Article, 2005

Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia., 2005 Journal Article, 2005

Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ, Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation., 2003 Journal Article, 2003

Fearon U, Griosios K, Fraser A, Reece R, Emery P, Jones PF, Veale DJ, Angiopoietins, growth factors, and vascular morphology in early arthritis., 2003 Journal Article, 2003

Bingham S, Veale D, Fearon U, Isaacs JD, Morgan G, Emery P, McGonagle D, Reece R, Clague R, Snowden JA, High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: short-term efficacy correlates with reduction of macroscopic and histologic synovitis., 2002 Journal Article, 2002

Fearon U, Veale DJ, Pathways of cell activation in spondyloarthropathies., 2001 Journal Article, 2001

Fraser A, Fearon U, Reece R, Emery P, Veale DJ, Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis., 2001 Journal Article, 2001

Fearon U, Veale DJ, Pathogenesis of psoriatic arthritis., 2001 Journal Article, 2001

Fearon U, Reece R, Smith J, Emery P, Veale DJ, Synovial cytokine and growth factor regulation of MMPs/TIMPs: implications for erosions and angiogenesis in early rheumatoid and psoriatic arthritis patients., 1999 Journal Article, 1999

Molloy ES, Clarke DM, Fearon UM, Cunningham SK, McKenna TJ, Non-ACTH POMC fragments stimulate aldosterone production by human adrenal cells in vitro., 1998 Journal Article, 1998

Fearon U, Clarke D, McKenna TJ, Cunningham SK, Intra-adrenal factors are not involved in the differential control of cortisol and adrenal androgens in human adrenals., 1998 Journal Article, 1998

McKenna TJ, Fearon U, Clarke D, Cunningham SK, A critical review of the origin and control of adrenal androgens., 1997 Journal Article, 1997

Clarke D, Fearon U, Cunningham SK, McKenna TJ, The steroidogenic effects of beta-endorphin and joining peptide: a potential role in the modulation of adrenal androgen production., 1996 Journal Article, 1996

Research Expertise

Keywords

ANGIOGENESIS; CELL SIGNALLING; CELL-MIGRATION; CELLULAR INVASION; Cytokine signalling; ENERGY-METABOLISM; HYPOXIA; Immunology, Immunotherapy; Mitochondrial function; Rheumatology and rheumatological disorders