Dr. Emma Creagh
Associate Professor, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Evaluating host responses to Helicobacter pylori using ELISA and Western Blot. in, Methods in Molecular Biology, Springer, 2021, pp175-190 , [C. Nulty, G. Barber, E. Flis, E.M. Creagh. ]
Agnew, A., Nulty, C., Creagh, E.M., Regulation, Activation and Function of Caspase-11 during Health and Disease., International Journal of Molecular Science, 22, (4), 2021, p1506-
Zaslona Z, Flis E, Nulty C, Kearney J, Fitzgerald R, Douglas AR, McNamara D, Smith S, O'Neill LAJ, Creagh EM., Caspase-4: A Therapeutic Target for Peptic Ulcer Disease, Immunohorizons, 4, (10), 2021, p627 - 633
E. Flis, G. Barber, C. Nulty, B. Keogh, P. McGuirk, A. Anand, J. O'Sullivan, M. Quante, E.M. Creagh. , Identification of TLR2 signalling mechanisms which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression, Cancers (Basel) , 13, (9), 2021, p2065 - 2081
Z. Zas³ona , E. Flis, M.M. Wilk, R.G. Carroll, E.M. Palsson-McDermott, M.M. Hughes, C. Diskin, K. Banahan, D.G. Ryan, A. Hooftman, A. Misiak, J. Kearney, G. Lochnit, W. Bertrams, T. Greulich, B. Schmeck, O.J. McElvaney, K.H.G. Mills, E.C. Lavelle, M. Wygrecka, E.M. Creagh & L.A.J. O'Neill , Caspase-11 promotes allergic airway inflammation, Nature Communications, 2020
G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, A. B. Heeran, E. Flis, N. E. Clarke, J. A. Watson, J. Strangmann, B. Flood, H. O'Neill, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Characterizing caspase-1 involvement during esophageal disease progression. , Cancer Immunology Immunotherapy, 69, (12), 2020, p2635 - 2649
Creagh, E.M., Kay, E.W., Flood, B., Oficjalska, K., Doherty, G. and Ryan, E., 'Method And Kit For Identification Of Inflamed And Malignant Intestinal Tissue', Trinity Technical Transfer Office, EP14182681.8 , 2020, Trinity College
Flis E. & Creagh E.M., HMGB1- mediates inflammatory TLR2 pathways during oesophageal adenocarcinoma, IACR 56th Annual Conference, Galway, Ireland, 26-28 February 2020, 2020
Nulty C. & Creagh E.M., The Influence of Hormone Receptor Status on the Expression of Inflammatory Caspases in Tumour Microenvironment, IACR 56th Annual Conference, Galway, Ireland, 26-28 February 2020, 2020
Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674
G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Identifying a role for caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma., IACR 55th Annual Conference, Belfast, Northern Ireland, February 2019, 2019
G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., ''Involvement of caspase-1 during progression to Barrett's oesophagus and oesophageal adenocarcinoma, 11th International Cancer Conference, TCD, TTMI, Dublin, Ireland, September 2019, 2019
Kufer, T.A., Creagh, E.M. & Bryant C., Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense, Trends in Immunology, 11, (10), 2019
Creagh, E.M., Inflammatory caspases during colorectal cancer, Cancer Biology & Immunology World Congress, Milan, Italy, March 11-13th 2019, 2019
G. Barber, K. Oficjalska, J.J. Phelan, N. E. Clarke, J. A. Watson, J. V. Reynolds, E.W. Kay, J. O'Sullivan, E.M. Creagh., Caspase-1 involvement during Barrett's and OAC progression., Oesophageal Cancer Symposium, Cancer Research UK (CRUK), London, UK, April, 2019, 2019
Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019, p2389 - 2393
Ryan, EJ and Creagh, EM, Emerging Methods in Colorectal Cancer Screening, British Journal of Surgery, 105, (2), 2018, p16 - 18
Flis, E and Creagh, E.M., STAT1-mediated tumour suppression is regulated by caspase-11 in a murine model of colitis-associated carcinogenesis., Toll 2018 - Editing Innate Immunity., Porto, Portugal., 2018
Kenealy, S. & Creagh, E.M., Novel NLRP6 mutation identified in a patient with an unexplained autoinflammatory disporder, Toll 2018 - Editing Innate Immunity., Porto, Portugal., 6-9 June 2018, 2018
Creagh, E.M., Oesophageal Cancer & Inflammation, Cologne University Research Hospital Seminar Series, Cologne University Research Hospital, Germany, 2nd June, 2017, Dr. H. Fuchs & Prof. J. Beers, Cologne
Flood B, Oficjalska K, Fay J, O'Grady A, Ryan EJ, Doherty GA, Kay E and Creagh EM. , Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients. , Gasteroenterology, Digestive Diseases Week (DDW), San Diego, CA, 19-24 May 2016, 150, (4), American Gastroenterology Association (AGA), 2016, ppS616-S617
Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia , 'Innovation in Diagnosis & Treatment of Colorectal Neoplasia', Centre for Colorectal Disease, St. Vincent's Hospital, 9th September, 2016, Prof. K Sheahan
Creagh, E.M., Inflammatory Caspase Expression during Colorectal Neoplasia, Irish Society of Gastroenterology, Summer Proceedings, Irish Society of Gastroenterology, Summer Meeting, Galway, Ireland., June 2016, edited by Michael Dineen, ISG , 2016
Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2
Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60
Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260
Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50
Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer , Irish Society of Gastroenterology Winter Proceedings, Dublin, Ireland, 21, 22nd November, 2014
Creagh, E.M., The role of inflammatory caspases during intestinal immunity, Biochemistry lecture series, Maynooth University, Ireland, 11 February, 2014
Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer, Living with Cancer in the 21st Century, Trinity College Dublin, September 2014, 2014
Creagh, E.M., A protective role for caspase-11 during acute experimental murine colitis, Faculty of Medicine and Health Sciences Research Seminar Series, Ghent University, Belgium , 16th December, 2014
Creagh E.M., Caspase crosstalk: integration of apoptotic and innate immune signalling pathways., Trends in Immunology, 35, (12), 2014, p631 - 640
Oficjalska, K., Creagh, E.M., A Protective Role for Caspase-11 during Acute Experimental Colitis, British Society of Immunology Annual Meeting, Brighton, UK, 2-4th December 2014, 2014
Ofijalska, K. and Creagh, E.M., Role of caspase-11 in a DSS-colitis model of IBD, The innate immune response in the pathogenesis of infectious disease, Minas Gerais, Brazil, 10-15 May 2013, 2013
James Fogarty, Innovations in Irish Research, Medical Independent, March, 2013
Creagh, E.M., Inflammatory caspases during IBD, Broad Medical Research Program 'Advances in Understanding IBD', Los Angeles, USA, 22, 23 February 2012, edited by Prof. Daniel Hollander , 2012
Oficjalska, K., Laukens, D. and Creagh, E.M., Investigation of the role of caspases in a DSS-colitis model of IBD, Irish Society of Gastroenterology Winter Meeting, Dublin, Ireland, 23rd-24th Nov. 2012, 2012
Harris, J..Hartman, M., Roche, C., Zeng, S.G., O'Shea, A., Sharp, F.A., Lambe, E.M., Creagh, E.M., Golenbock, D.T., Tschopp, J., Kornfeld, H., Fitzgerald, K.A. and Lavelle, E.C , Autophagy controls IL-1ß secretion by targeting pro-IL-1ß for degradation, The Journal of Biological Chemistry, 286, 2011, p9587 - 9597
Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28
Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875
Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537
Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ, Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival., PloS one, 4, (3), 2009, pe5055
Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357
Murphy BM, Creagh EM, Martin SJ, Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36916 - 36922
Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ, Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (26), 2004, p26906 - 26914
Adrain C, Creagh EM, Cullen SP, Martin SJ, Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36923 - 36930
Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ, Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes, EMBO JOURNAL, 23, (10), 2004, p2134 - 2145
Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11
Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11
Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21
Adrain C, Creagh EM, Martin SJ, Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2, THE EMBO JOURNAL, 20, 2001, p6627 - 6636
Creagh EM, Martin SJ, Caspases: cellular demolition experts., BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p696 - 702
Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, (47), 2001, p44069-77
Creagh E.M., Sheehan D. and Cotter T.G. , Heat shock proteins - modulators of apoptosis in tumour cells, Leukemia , 14, 2000, p1161-1173
Creagh EM, Carmody RJ, Cotter TG, Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells., Experimental cell research, 257, (1), 2000, p58-66
E M CREAGH and T G COTTER, Selective protection by hsp 70 against cytotoxic drug - but not Fas-induced T-cell apoptosis, Immunology, 97, (1), 1999, p36-44
Devitt GP, Creagh EM, Cotter TG, The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization., Biochemical and biophysical research communications, 264, (3), 1999, p622-9
Gorman AM, Heavey B, Creagh E, Cotter TG, Samali A, Antioxidant-mediated inhibition of the heat shock response leads to apoptosis., FEBS letters, 445, (1), 1999, p98-102
Non-Peer-Reviewed Publications
Creagh, E.M., Contribution of Inflammatory caspases to IBD & CRC, INITIative Network meeting, Dublin, Ireland, 23rd November 2018, 2018
Flis, E and Creagh, E.M., Role of TLR2 in Oesophageal Adenocarcinoma Progression, Training in Cancer Mechanisms & Therapeutics Meeting, Queens University, Belfast, 16th April 2018, 2018
Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin]
Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin]
Research Expertise
Recognition
Awards and Honours
Wellcome Trust Career Development Fellowship
Broad Medical Research Program Fellowship
TCD Pathfinder Award
Winner - Oral presentation - Irish Society of Gastroenterology Meeting
Voted 'Favorite Woman in Science' 2017, 2018 and 2019 by TCD General Science Students
Elected Senior Council Member - Irish Association for Cancer Research (IACR).
Memberships
Irish Association for Cancer Research (Senior Council Member since 2020)
American Society for Immunology
International Society for Mucosal Immunology
Irish Society of Gastroenterology
Irish Society of Immunology
Irish Epithelial Physiology Group