Emma Creagh
Assistant Professor, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Basdeo S.A, Campbell N.K, Sullivan L.M, Flood B, Creagh E.M, Mantle T.J, Fletcher J.M, Dunne A, Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation, Translational Research, 178, 2016, p81-94.e2 Journal Article, 2016 TARA - Full Text URL DOI

Flood B, Oficjalska K, Fay J, O'Grady A, Ryan EJ, Doherty GA, Kay E and Creagh EM. , Epithelial expression of inflammatory caspases-4 and -5 is specific to malignancy in colorectal cancer patients. , Gasteroenterology, Digestive Diseases Week (DDW), San Diego, CA, 19-24 May 2016, 150, (4), American Gastroenterology Association (AGA), 2016, ppS616-S617 Conference Paper, 2016 TARA - Full Text DOI

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 DOI TARA - Full Text

Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50 Journal Article, 2015 TARA - Full Text DOI

Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260 Journal Article, 2015 TARA - Full Text DOI

Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer , Irish Society of Gastroenterology Winter Proceedings, Dublin, Ireland, 21, 22nd November, 2014 Poster, 2014

Flood, B. Oficjalska, K. Creagh, E.M., Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer, Living with Cancer in the 21st Century, Trinity College Dublin, September 2014, 2014 Poster, 2014

Oficjalska, K., Creagh, E.M., A Protective Role for Caspase-11 during Acute Experimental Colitis, British Society of Immunology Annual Meeting, Brighton, UK, 2-4th December 2014, 2014 Poster, 2014

Creagh, E.M., A protective role for caspase-11 during acute experimental murine colitis, Faculty of Medicine and Health Sciences Research Seminar Series, Ghent University, Belgium , 16th December, 2014 Conference Paper, 2014

Creagh E.M., Caspase crosstalk: integration of apoptotic and innate immune signalling pathways., Trends in Immunology, 35, (12), 2014, p631 - 640 Journal Article, 2014 DOI

Creagh, E.M., The role of inflammatory caspases during intestinal immunity, Biochemistry lecture series, Maynooth University, Ireland, 11 February, 2014 Conference Paper, 2014

Ofijalska, K. and Creagh, E.M., Role of caspase-11 in a DSS-colitis model of IBD, The innate immune response in the pathogenesis of infectious disease, Minas Gerais, Brazil, 10-15 May 2013, 2013 Poster, 2013

James Fogarty, Innovations in Irish Research, Medical Independent, March, 2013 Report, 2013 URL

Creagh, E.M., Inflammatory caspases during IBD, Broad Medical Research Program 'Advances in Understanding IBD', Los Angeles, USA, 22, 23 February 2012, edited by Prof. Daniel Hollander , 2012 Oral Presentation, 2012

Oficjalska, K., Laukens, D. and Creagh, E.M., Investigation of the role of caspases in a DSS-colitis model of IBD, Irish Society of Gastroenterology Winter Meeting, Dublin, Ireland, 23rd-24th Nov. 2012, 2012 Oral Presentation, 2012

Harris, J..Hartman, M., Roche, C., Zeng, S.G., O'Shea, A., Sharp, F.A., Lambe, E.M., Creagh, E.M., Golenbock, D.T., Tschopp, J., Kornfeld, H., Fitzgerald, K.A. and Lavelle, E.C , Autophagy controls IL-1ß secretion by targeting pro-IL-1ß for degradation, The Journal of Biological Chemistry, 286, 2011, p9587 - 9597 Journal Article, 2011 TARA - Full Text

Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28 Journal Article, 2010

Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875 Journal Article, 2009 TARA - Full Text DOI

Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537 Journal Article, 2009 DOI TARA - Full Text

Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ, Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival., PloS one, 4, (3), 2009, pe5055 Journal Article, 2009 TARA - Full Text DOI

Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357 Journal Article, 2006 URL DOI

Murphy BM, Creagh EM, Martin SJ, Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36916 - 36922 Journal Article, 2004 TARA - Full Text

Adrain C, Creagh EM, Cullen SP, Martin SJ, Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36923 - 36930 Journal Article, 2004 DOI TARA - Full Text URL

Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ, Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (26), 2004, p26906 - 26914 Journal Article, 2004 DOI TARA - Full Text URL

Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ, Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes, EMBO JOURNAL, 23, (10), 2004, p2134 - 2145 Journal Article, 2004

Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21 Journal Article, 2003

Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11 Journal Article, 2003

Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11 Journal Article, 2003

Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, (47), 2001, p44069-77 Journal Article, 2001 DOI TARA - Full Text

Adrain C, Creagh EM, Martin SJ, Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2, THE EMBO JOURNAL, 20, 2001, p6627 - 6636 Journal Article, 2001 TARA - Full Text

Creagh E.M., Sheehan D. and Cotter T.G. , Heat shock proteins - modulators of apoptosis in tumour cells, Leukemia , 14, 2000, p1161-1173 Review Article, 2000

Creagh EM, Carmody RJ, Cotter TG, Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells., Experimental cell research, 257, (1), 2000, p58-66 Journal Article, 2000

E M CREAGH and T G COTTER, Selective protection by hsp 70 against cytotoxic drug - but not Fas-induced T-cell apoptosis, Immunology, 97, (1), 1999, p36-44 Journal Article, 1999

Devitt GP, Creagh EM, Cotter TG, The antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole inhibits apoptosis by preventing caspase activation following mitochondrial depolarization., Biochemical and biophysical research communications, 264, (3), 1999, p622-9 Journal Article, 1999

Gorman AM, Heavey B, Creagh E, Cotter TG, Samali A, Antioxidant-mediated inhibition of the heat shock response leads to apoptosis., FEBS letters, 445, (1), 1999, p98-102 Journal Article, 1999

Creagh, E.M., Kay, E.W., Flood, B., Oficjalska, K., Doherty, G. and Ryan, E., 'Method And Kit For Identification Of Inflamed And Malignant Intestinal Tissue', Trinity Technical Transfer Office, 28 August 2014, Trinity College Patent, Other

Non-Peer-Reviewed Publications

Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin] Book Chapter, 2003

Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin] Book Chapter, 2002