Dr. Fabio Boylan
Associate Professor, Pharmacy
Biography
Born in Rio de Janeiro, Brazil, in 15 of February of 1972. Fabio Boylan studied Pharmacy at Rio de Janeiro Federal University, in Rio de Janeiro, Brazil. From February 1996 to February 1998, he was Lecturer at the Department of Pharmacognosy, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. His Master project "Phylogenetic Trends within Lamiiflorae" was sponsored by CNPq, a Brazilian Governmental Agency for 1.5 years and he got the degree after being evaluated by Dr. Otto Richard Gottlieb. His Ph.D. project "Chemical and Pharmacological Studies on Raphiodon echinus and Marsypianthes chamaedrys" was sponsored by CAPES, another Brazilian Governmental Agency. In several years he was awarded with grants from FAPERJ (Rio de Janeiro Research Supporting Agency) and FINEP in 2003 when he had the opportunity to chair the XII Italian-Latin-American Conference on Ethnomedicine. Also in 2003 he was awarded with a special grant from CNPq due to his scientific collaboration to the Brazilian Science. Fabio stepped up as a senior lecturer at the Faculty of Pharmacy, Federal University of Rio de Janeiro in 1998. In 2006, he started his sabbatical year in the School of Pharmacy and Pharmaceutical Sciences, TCD, where he further served as a research coordinator from 2007-2008 and now is a full time lecturer in Pharmacognosy. He acts an ad hoc reviewer for the following scientific journals: Brazilian Journal of Pharmacognosy, Brazilian Journal of Medicinal Plants, Brazilian Journal of Microbiology, Brazilian Journal of Pharmaceutical Sciences, Phytochemistry, Iheringia Zoologia (Section Botany), Phytotherapy Research, Current Medicinal Chemistry, African Journal of Pharmacology and Pharmaceutical Sciences, Molecules, Frontiers in Pharmacology, Antioxidants, Journal of Chromatography, among others.
Publications and Further Research Outputs
Peer-Reviewed Publications
Mladenovic Marko Z, Ristic Milenko N, Bogdanovic Andrija I, Ristic Novica R, Boylan Fabi, Radulovic Niko S, Wax Composition of Serbian Dianthus spp. (Caryophyllaceae): Identification of New Metabolites and Chemotaxonomic Implications, PLANTS-BASEL, 12, (11), 2023
Silveira Damari, Boylan Fabio, Medicinal Plants: Advances in Phytochemistry and Ethnobotany, PLANTS-BASEL, 12, (8), 2023
Fernandes Felipe Hugo Alenca, Soares Sabrina da Silv, Bekbolatova Elmir, Boylan Fabio, Salgado Herida Regina Nune, Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson, NATURAL PRODUCT RESEARCH, 2023
Radulovic Niko S, Mladenovic Marko Z, Dekic Milan S, Boylan Fabio, Synthesis of Small Libraries of Natural Products: Part II: Identification of a New Natural Product from the Essential Oil of Pleurospermum austriacum (L.) Hoffm. (Apiaceae), MOLECULES, 28, (12), 2023
MENSOR, L. L. ; MENEZES, F. S. ; LEITÃO, Gilda Guimarães ; REIS, A. S. ; SANTOS, T. C. ; COUBE, C. S. ; LEITÃO, Suzana Guimarães , Screening of Brazilian Plant Extracts for Antioxidant Activity by the Use of DPPH Free Radical Method, Phytotherapy Research, 15, (2), 2001, p127 - 130
SILVA, Carmelita G ; HERDEIRO, R S ; MATHIAS, C J ; PANEK, Anita Dolly ; SILVEIRA, Cristiane Silva ; RODRIGUES, Verônica Pinto ; RENNÓ, Magdalena Nascimento ; FALCÃO, Deborah Quintanilha ; CERQUEIRA, Débora Malta ; MINTO, Andréa Barreto Mattos ; NOGUEIRA, Fábio Luis Pereira ; QUARESMA, Carla Holandino ; SILVA, Joaquim Fernando Mendes da ; MENEZES, F. S. ; ELEUTHERIO, Elis Cristina de Araújo, Evaluation of Antioxidant Activity of Brazilian Plants, Pharmacological Research, 52, (3), 2005, p229 - 233
MATHEUS, Maria Eline ; BERRONDO, Luciane Fátima ; VIEITAS, Eniana Campolina ; MENEZES, F. S. ; FERNANDES, Patrícia Dias , Evaluation of the Antinociceptive Properties from Brillantaisia palisotii Lindau Stems Extracts, Journal of Ethnopharmacology, 102, (3), 2005, p377 - 381
Amado, NG; Cerqueira, DM; Menezes, FS; Silva, JFM; Neto, V.M.; Abreu, J.G., Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes B-catenin cellular localization, Anti Cancer Drugs, 20, (7), 2009, p543 - 552
de Sousa, VP, Crean, J, Borges, VRD, Rodrigues, CR, Tajber, L, Boylan, F, Cabral, LM, Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia, INTERNATIONAL JOURNAL OF NANOMEDICINE, 8, 2013, p3129-3139
C.G. Silva, R. Raulino, D.M. Cerqueira, M.D. Pereira, A.D. Panek, J.F.M. Silva, E.C.A. Eleutherio, F.S. Menezes., In vitro and in vivo determination of antioxidant activity and mode ofaction of isoquercitrin and Hyptis fasciculata, Phytomedicine, 2009
MENEZES, F. S. ; BORSATTO, Â. S. ; PEREIRA, Nuno Álvares ; MATOS, F. J. A. ; KAPLAN, Maria Auxiliadora Coelho , Chamaedrydiol, an Ursane Triterpene from Marsypianthes chamaedrys., Phytochemistry, 48, (2), 1998, p323 - 325
Pinheiro, MMG; Bessa, SO; Fingolo, CE; Kuster, RM; Matheus, ME; Menezes, FS; Fernandes, PD, Antinociceptive activity of fractions from Couroupita guianensis Aubl. leaves , Journal of Ethnopharmacology, 127, (2), 2010, p407 - 413
Radulovic, N; Blagojevic, PD; Rabbitt, K ; Menezes, FD , Essential oil of Nepeta x faassenii Bergmans ex Stearn (N. mussinii Spreng. x N. nepetella L.): A Comparison Study , Natural Product Communications, 6, (7), 2011, p1015 - 1022
Niko S. Radulović, Ana B. Miltojević, Michael McDermott, Steve Waldren, John Adrian Parnell, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio de Sousa Menezes, Identification of a new antinociceptive alkaloid isopropyl N-methylanthranilate from the essential oil of Choisya ternata Kunth, Journal of Ethnopharmacology, 135, (3), 2011, p610-619
Magdalena Rennó, Gleyce Barbosa, Patricia Zancan, Venicio Veiga, Celuta Alviano, Mauro Sola-Penna, Fábio S. Menezes and Carla Holandino Quaresma, Crude ethanolic extract of Babassu (Orbignya speciosa): cytoxicity on tumoral and non-tumoral cell lines, Anals of the Brazilian Academy of Science, 80, 2008, p467 - 476
Martins, FO; Esteves, PF; Mendes, GS; Barbi, NS; Menezes, FS; Romanos, MTV , Verbascoside isolated from Lepechinia speciosa has inhibitory Activity against HSV-1 and HSV-2 in vitro , Natural Product Communications, 4, (12), 2009, p1693 - 1696
Xue L, Radomski A, Corrigan OI, Tajber L, de Souza Menezes F, Endter S, Medina C, Radomski M, Platelet compatibility of PLGA, chitosan and PLGA-chitosan nanoparticles, Nanomedicine, 4, (7), 2009, p735 - 746
BERRONDO, Luciane Fátima ; GABRIEL, Felipe Teixeira ; FERNANDES, Sidnei Bessa de Oliveira ; MOREIRA, Davyson de Lima ; MENEZES, F. S. , Dirhamnosyl flavonoid and other constituents from Brillantaisia palisatii. , Quimica Nova, 26, (6), 2003, p922 - 923
Wahab IR, Wong NS, Boylan F, Choisyaternatine, a new alkaloid isolated from Choisya ternata., Planta medica, 78, (14), 2012, p1597-600
Niko Radulović, Nevenka Đorđević, Marija Denić, Mariana Martins Gomes Pinheiro, Patricia Dias Fernandes, Fabio Boylan, A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity, Food and Chemical Toxicology, 50, (2), 2012, p274-279
Pinheiro, MMG, Radulovic, NS, Miltojevic, AB, Boylan, F, Fernandes, PD, Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain, EUROPEAN JOURNAL OF PHARMACOLOGY, 727, 2014, p106-114
Abdul-Wahab IR, Guilhon CC, Fernandes PD, Boylan F, Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts., Journal of ethnopharmacology, 144, (3), 2012, p741-6
Pinheiro MM, Fernandes SB, Fingolo CE, Boylan F, Fernandes PD, Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves., Journal of ethnopharmacology, 146, (1), 2013, p324-330
Radulovic, NS, Miltojevic, AB, Randjelovic, PJ, Stojanovic, NM, Boylan, F, Effects of Methyl and Isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on Experimental Anxiety and Depression in Mice, PHYTOTHERAPY RESEARCH, 27, (9), 2013, p1334-1338
Wahab IR, Wong NS, Boylan F, Choisyaternatine, a new alkaloid isolated from Choisya ternata., Planta medica, 78, (18), 2012, p1983
Wahab IR, Blagojevi" PD, Radulovi" NS, Boylan F, Volatiles of Curcuma mangga Val. & Zijp (Zingiberaceae) from Malaysia., Chemistry & biodiversity, 8, (11), 2011, p2005-14
Pinheiro MM, Boylan F, Fernandes PD, Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: evidence for the involvement of apigenin., Life sciences, 91, (9-10), 2012, p293-300
Souza, P.A.V.R., Jr, A.P., Alves, L.M., Souza, V.P., Cabral, L.M., Fernandes, P.D., Takiya, C.M., Menezes, F.S., Nasciutti, L.E.,, Effects of a nanocomposite containing Orbignya speciosa lipophilic extract on Benign Prostatic Hyperplasia, Journal of Ethnopharmacology, 135, (1), 2011, p135-146
Frankish, N; Menezes, FD; Mills, C; Sheridan, H, Enhancement of Insulin Release from the beta-Cell Line INS-1 by an Ethanolic Extract of Bauhinia variegata and Its Major Constituent Roseoside, Panta Medica, 76, (10), 2010, p995 - 997
Rocha, FD; Yano, M; da Cunha, MR; Gabriel, FT; Cordeiro, RSB; Menezes, FS ; Kaplan, MAC, Brazilian Bromeliaceae species: isolation of arylpropanoid acid derivatives and antiradical potential , REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY , 20, (2), 2010, p240 - 245
Esteves, PF; Kuster, RM; Barbi, ND; Menezes, FD, Chemical Composition and Cytotoxic Activity of Lepechinia speciosa (St. Hill) Epling , Latin American Journal of Pharmacy, 29, (1), 2010, p38 - 44
Paula Macedo Lessa dos Santos; Alberto Sadda Japp; Lívia Gralato Lima; Jan Schripsema; Fábio de Sousa Menezes; Ricardo Machado Kuster, Antioxidant activity from the leaf extracts of Jacaranda puberula Cham., Bignoniaceae, a Brazilian medicinal plant used for blood depuration, Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy , 20, (2), 2010, p147 - 153
Martins, FO; Gomes, MMD; Nogueira, FLP; Martins, GR; Romanos, MTV ; Kaplan, MAC; Menezes, FD, In vitro inhibitory effect of Urera baccifera (L.) Gaudich. extracts against herpes simplex , African Journal of Pharmacy and Pharmacology, 3, (11), 2009, p581 - 584
Silveira, CS; Martins, FO Costa, CD; Romanos, MTV ; Kaplan, MAC; Menezes, FD, In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts, Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 19, (2A), 2009, p343 - 348
Antinociceptive and Anti-Inflammatory Activities of the Orbignya speciosa (Mart.) Barb. Rodr. -(Babassu) Extracts in, editor(s)J.N. Govil, Rajeev Kr. Sharma , Phytopharmacology and Therapeutic Values - Recent Progress in Medicinal Plants, USA, Studium Press, 2008, pp29 - 38, [Renno, M.N., Reis, G.M., Quaresma, C.H., Menezes, F.S., Matheus, M.E., Fernandes, P.D.]
Evaluation of antinociceptive and anti-inflammatory effects of Brillantaisia palisotii Lind. leaves in, editor(s)J.N.Govil, Rajeev Kr. Sharma , Phytopharmacology and Therapeutic Values - Recent Progress in Medicinal Plants, USA, Stadium Press, 2008, pp19 - 28, [Fernandes, P.D., Matheus, M.E., Menezes, F.S.]
FALCÃO, Deborah Quintanilha ; COSTA, Edlaine Rijo ; ALVIANO, Daniela Sales ; ALVIANO, Celuta Sales ; KUSTER, Ricardo Machado ; MENEZES, F. S. , Effect of Dryness Time on the Essential Oil Content and Its Antimicrobial Activity in Ocimum basilicum L.. , Pharmacologyonline, 1, 2008, p1 - 6
Anti-inflammatory and Analgesic Activities of two Palmae Species Fruits Rich in Fatty Acids in, Anuario de Investigación en Etnomedicina y Estudios de Utilización de Plantas Medicinales, Iztapalapa - Mexico, 2007, pp45 - 48, [Silveira, C.S., Reis, G.M., Pessanha, C.M., Menezes, F.S., Kaplan, M.A.C., Fernandes, P.D. Matheus, M.E.]
Castilhos, T.S., Giordani, R.B., Henriques, A.T., Menezes, F.S., Zuanazzi, J.A.S., In vitro evaluation of the antioxidant, anti-inflammatory and antimicrobial activities of the montanine alkaloid, Brazilian Journal of Pharmacognosy, 17, (2), 2007, p209 - 214
Falcão, D.Q., Costa, E.R., Kuster, L.M., Vian, L., Nielloud, F., Menezes, F.S., The obtention of an oil/water nanoemulsion containing the Calceolaria chelidonioides flowers ethanol extract and its skin hydration power, Planta Medica, 73, 2007, p631 - 631
Falcão, D.Q., Costa, E.R., Kuster, R.M., Nielloud, F., Vian, L., Menezes, F.S., Evaluation of Cytotoxicity, Phototoxicity and Genotoxicity from Calceolaria chelidonioides (Scrophulariaceae) Flowers Ethanol Extract., Planta Medica, 73, 2007, p477 - 477
Vicentino, A.R.R., Menezes, F.S., Antioxidant Activity of Plant Tinctures sold in Pharmacies and Indicated for Several Types of Diseases, Using the DPPH Methodology, Brazilian Journal of Pharmacognosy, 17, (3), 2007, p384 - 387
Boscolo, O.H., Mendonça-Filho, R.F.W., Menezes, F.S., Valle, L.S., The antioxidant Power of Some Restinga Plants Cited as Medicines, Brazilian Journal of Medicinal Plants, 9, (1), 2007, p8 - 12
Menezes, F.S., Minto, A.B.M.. Ruella, H.S., Kuster, R.M., Sheridan, H., Frankish, N., Hypoglycemic activity of two Brazilian Bauhinia species: Bauhinia forficata L. and Bauhinia monandra Kurz., Brazilian Journal of Pharmacognosy, 17, (1), 2007, p14 - 18
MENEZES, F. S. ; KAPLAN, Maria Auxiliador Coelho , In-Mixture Analysis of Triterpenes from Raphiodon echinus. , Revista latinoamericana de quimica, 34, 2006, p37 - 41
Reis, GM; Silveira, CS; Pessanha, CM; Menezes, FS; Kaplan, MAC; Fernandes, PD; Matheus, ME., Pharmacological study of Syagrus oleraceae (Martius) Beccari and Mauritia vinifera Martius fruit extracts, Brazilian Journal of Medicinal Plants, 8, 2006, p144 - 150
Falcão, DQ; Costa, ER; Menezes, FS; Kuster, RM., Ethnopharmacological study of plants used topically by the community of Macabú (RJ) and its essential oil chemistry evaluation , Brazilian Journal of Medicinal Plants, 8, 2006, p172 - 174
MENEZES, F. S. ; FALCÃO, Deborah Quintanilha ; MENDONÇA FILHO, Robert Frederic Woolley de ; SILVEIRA, Cristiane Silva ; RENNÓ, Magdalena Nascimento ; RODRIGUES, Verônica Pinto ; MINTO, Andrea Barreto Mattos ; MOREIRA, Davyson de Lima ; MATHEUS, Maria Eline ; FERNANDES, Patrícia Dias ; KAPLAN, Maria Auxilkiadora Coelho , Chemical and Pharmacological Survey on Brazilian Medicinal Plants Using Ethnopharmacology Information as a Tool, Acta Horticultura, 675, 2005, p89 - 95
FALCÃO, Deborah Quintanilha ; COSTA, Edlaine Rijo ; ALVIANO, Daniela Sales ; ALVIANO, Celuta Sales ; KUSTER, Ricardo Machado ; MENEZES, F. S. , Antioxidant and Anti-Microbial Activity from Calceolaria chelidonioides Humb. Bonpl. & Kunth. , Brazilian Journal of Pharmacognosy, 16, (1), 2006, p73 - 76
Hypoglycemic Activity of Eight Brazilian Bauhinia Species . in, editor(s)Universidad Autónoma Metropolitana. , Anuario de Investigación en Etnomedicina y Estudios de Utilización de Plantas Medicinales., Istapalapa, Mexico, 2005, [1. MINTO, Andréa Barreto Mattos ; FERNANDES, Sidnei Bessa de Oliveira ; RUELLA, Halliny Siqueira ; KUSTER, Ricardo Machado ; PEREIRA, Nuno Álvares ; MENEZES, F. S.]
FALCÃO, Deborah Quintanilha ; FERNANDES, Sidnei Bessa de Oliveira ; MENEZES, F. S. , Triterpenes of Hyptis fasciculata Benth. , Brazilian Journal of Pharmacognosy, 13, (S1), 2003, p81 - 83
MATHEUS, Maria Eline ; MANTOVANI, Iara Sílvia Brauer ; SANTOS, Gracilene Barros dos ; FERNANDES, Sidnei Bessa de Oliveira ; MENEZES, F. S. ; FERNANDES, Patrícia Dias , Action of Açaí Extracts (Euterpe oleracea) on the Nitric Oxide Production in RAW264.7 Cells, Brazilian Journal Of Medicinal Plants, 13, (S1), 2003, p3 - 5
FALCÃO, Deborah Quintanilha ; MENEZES, F. S. , Chemical and Pharmacological review on Plants belonging to the genus Hyptis., Brazilian Journal of Pharmacy, 84, (3), 2003, p69 - 74
MARINHO, Bruno G ; HERDY, Simone A ; SÁ, Alessandra Cananéa de ; SANTOS, Gracilene Barros dos ; MATHEUS, Maria Eline ; MENEZES, F. S. ; FERNANDES, Patrícia Dias , Antinociceptive Activity of Açaí Extracts (Euterpe oleraceae Mart.). , Brazilian Journal of Pharmacognosy, 12, (Suplemment), 2002, p52 - 53
D'ELIA, P. S. ; MOTTA, A. F. R. ; MENEZES, F. S. , Comparison between aerobic work out and aerobic work out combined with L-carnitine and Garcinia cambogia in loosing weight., Brazilian Journal of Pharmacy, 83, (1-4), 2002, p45 - 49
Perspectives on the Use of Natural Products in Tropical Medicine in, editor(s)Rodrigo Siqueira Baptista , Tropical Medicine: Current Management of Infectious and Parasitary Diseases, Rio de Janeiro, Cultura Medica, 2001, pp51 - 60, [Menezes, F.S.]
MATOS, F. J. A. ; MACHADO, M. I. L. ; CRAVEIRO, A. A. ; ALENCAR, J. W. ; MENEZES, F. S., Essential Oil Composition of Marsypianthes chamaedrys (Vahl) Kuntze Grown in Northeast Brazil. , Journal of Essential Oil Research, 13, (1), 2001, p45 - 46
Phenolic Content X Antioxidant Activity: A Study on Plants Eaten by a Group of Howling Monkeys (Alouatta fusca). in, editor(s)Hemingway, Gross , Plant Polyphenols 2: Chemistry and Biology, USA, Plenum Press, 2000, pp883 - 895, [Leitao, G.G., Mensor, L.L., Amaral, L.F., Floriano, N., Limeira, V.L.G., Menezes, F.S., Leitao, S.G.]
GABRIEL, Felipe Teixeira ; MOREIRA, Davyson de Lima ; MENEZES, F. S. , Choosing the Best Methodology for the Extraction of Brillantaisia palisatii Lind. Leaves , Brazilian Journal of Pharmacy, 81, (4), 2000, p86 - 90
SÁ, Alessandra Cananéa de ; MORGADO, S. C. ; MOREIRA, Davyson de Lima ; MENEZES, F. S. , Preliminary chemical analysis of Brillantaisia palisotii Lind. leaves. , Brazilian Journal of Pharmacy, 81, (1/2), 2000, p36 - 38
MENEZES, F. S. ; SILVA, Célia Santos da ; PEREIRA, Nuno Álvares ; MATOS, F. J. A. ; BORSATTO, Â. S. ; KAPLAN, Maria Auxiliadora Coelho , Molluscicidal Constituents of Marsypianthes chamaedrys, Phytotherapy Research, 13, 1999, p433 - 435
MENEZES, F. S. ; BORSATTO, Â. S. ; PEREIRA, Nuno Álvares ; MATOS, F. J. A. ; KAPLAN, Maria Auxiliadora Coelho , Phytochemical and Pharmacological Studies on Raphiodon echinus., Fitoterapia, 69, (5), 1998, p459 - 460
MENEZES, F. S. ; BORSATTO, Â. S. ; PEREIRA, Nuno Álvares ; MATOS, F. J. A. ; KAPLAN, Maria Auxiliadora Coelho , Chemical Constituents of Marsypianthes chamaedrys. , Annals of the Brazilian Academy of Science, 70, (4), 1998, p761 - 766
MENEZES, F. S. , Current trends in the management of Duodenal Ulcer. , RBM - Brazilian Journal of Medicine, 54, (1/2), 1997, p45 - 50
MENEZES, F. S. ; PEREIRA, A. L. A. ; HOLLEBEN, B. S. S. , Investigation of medicinal plants use by the population of Ilha do Governador (RJ)., Brazil, Brazilian Journal of Pharmacy, 78, (2), 1997, p35 - 36
CORRÊA, A. D. ; SIQUEIRABAPTISTA, R. ; MENEZES, F. S. ; OLIVEIRA JÚNIOR, W. , Allium sativum: Clinical-Therapeutical Aspects, Brazilian Archives of Medicine, 70, (12), 1996, p613 - 614
CORRÊA, A. D. ; SIQUEIRABAPTISTA, R. ; MENEZES, F. S. ; QUINTAS, L. E. M. , Digitalics and cardiotonic glucosides, Brazilian Archives of Medicine, 70, (9), 1996, p473 - 476
MENEZES, F. S. ; RODRIGUES, V. S. ; KAPLAN, Maria Auxiliadora Coelho , Chemistry as a tool for the determination of Botany evolutionary trends: the family Gesneriaceae. , Brazilian Journal of Pharmacy, 77, (1), 1996, p34 - 36
MENEZES, F. S. ; KAPLAN, Maria Auxiliadora Coelho ; GOTTLIEB, O. R. , Chemo-Evolutionary Polarizations within Lamiiflorae. , Annals of the Brazilian Academy of Science, 67, (3), 1995, p455 - 460
MENEZES, F. S. ; KAPLAN, Maria Auxiliadora Coelho , Ocurrency of Diterpenoids in Lamiaceae family. , Brazilian Journal of Pharmacy, 74, (2), 1993, p45 - 46
MENEZES, F. S. ; KAPLAN, Maria Auxiliadora Coelho , Plants from the subfamily Ocimoideae employed in folk medicine: Ethnopharmacology X Chemistry. , Brazilian Journal of Pharmacy, 73, (2), 1992, p30 - 32
LEITÃO, Gilda Guimarães ; MENEZES, F. S. ; LOPES, D. ; KAPLAN, Maria Auxiliadora Coelho ; CRAVEIRO, A. A. ; ALENCAR, J. W. , Essential Oils from Brazilian Aristolochia. , Journal of Essential Oil Research, 3, (6), 1991, p403 - 408
Coady, Yvonne Boylan, Fabio, Ethnopharmacology in Ireland: an overview, Revista Brasileira de Farmacognosia, 24, (2), 2014, p197 - 205
Guilhon, Carolina Carvalho, Abdul Wahab, Ikarastika Rahayu, Boylan, Fabio, Fernandes, Patricia Dias, Central Antinociceptive and Mechanism of Action of Pereskia bleo Kunth Leaves Crude Extract, Fractions, and Isolated Compounds., Evidence-based complementary and alternative medicine : eCAM, 2015, 2015, p915927
Gomes Pinheiro, Mariana Martins, Miltojevic, Ana B., Radulovic, Niko S., Abdul-Wahab, Ikarastika Rahayu, Boylan, Fabio, Fernandes, Patricia Dias, Anti-Inflammatory Activity of Choisya ternata Kunth Essential Oil, Ternanthranin, and Its Two Synthetic Analogs (Methyl and Propyl N-Methylanthranilates), Plos One, 10, (3), 2015, pe0121063-
English, M., Pinheiro, M.M.G., Sardella, T.B., Fernandes, P.D., Abdul-Wahab, I.R., O'Sullivan, L., Boylan, F., Antinociceptive evaluation of Buddleja davidii Franch flower extracts and the involvement of martynoside, Current Topics in Pharmacology, 18, (1-2), 2014, p93-103
Ropero, D., Guilhon, C. C., Fernandes, P. D., Boylan, F., Pharmacological investigation of Choisya Aztec Pearl, Planta Medica, 80, (16), 2014, p1504
Carvalho, P. R., Guilhon, C. C., Ropero, D., Boylan, F., Fernandes, P. D., Evaluation of antinociceptive and/or anti-inflammatory activity of Choisya Aztec Pearl, Planta Medica, 80, (16), 2014, p1490
Zhang, Q., Guilhon, C. C., Fernandes, P. D., Boylan, F., Antinociceptive and anti-inflammatory activities of Elsholtzia ciliata (Thunb.) Hyl. (Lamiaceae) extracts, Planta Medica, 80, (16), 2014, p1406
Wahab, Ikarastika Rahayu Abdul, Wong, Nikki Siu Hai, Boylan, Fabio, CCDC 865486: Experimental Crystal Structure Determination, Cambridge Structural Database, 2013
Guilhon, C. C., Wahab, I. R. A., Boylan, F., Fernandes, P. D., Evaluation of antinociceptive activity of Pereskia bleo Kunth, Planta Medica, 78, (11), 2012, p1098
do Amaral, R.R., Santos, A.A.D., Saravia, A., Botas, G., Cruz, R.A.S., Fernandes, C.P., Rocha, L., Boylan, F., Biological activities of Arrabidaea chica (Bonpl.) B. Verl. leaves, Latin American Journal of Pharmacy, 31, (3), 2012, p451-455
Cunningham, Francis, Menezes, Fabio S., Ethnopharmacology in Dublin: surveys on the medicinal plants use profile, Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy, 21, (5), 2011, p814-817
Matheus, Maria Eline, de Oliveira Fernandes, Sidnei Bessa, Silveira, Cristiane Silva, Rodrigues, Veronica Pinto, Menezes, Fabio de Sousa, Fernandes, Patricia Dias, Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression, Journal of Ethnopharmacology, 107, (2), 2006, p291-296
Silveira, C.S., Pessanha, C.M., Lourenço, M.C.S., Neves Junior, I., Menezes, F.S., Kaplan, M.A.C., Atividade antimicrobiana dos frutos de Syagrus oleracea e Mauritia vinifera, Revista Brasileira de Farmacognosia, 15, (2), 2005, p143-148
Nogueira, F.L.P., Fernandes, S.B.O., Reis, G.M., Matheus, M.E., Fernandes, P.D., Lage, C.L.S., Menezes, F.S., Atividade analgésica e antiedematogênica de Polygala paniculata L. (Polygalaceae) selvagem e obtida por micropropagação, Revista Brasileira de Farmacognosia, 15, (4), 2005, p310-315
Arruda, D. C., Felippi, R., Mantovani, I. S. B., Santos, G. B., Gabriel, F. T., de Sa, A. C., Fernandes, S. B. de O., Ribeiro-do-Valle, R. M., Menezes, F. S., Ckless, K., Antioxidant activity and dosage of phenolics of Euterpe oleracea Mart extract. (acai)., Revista Brasileira de Plantas Medicinais, 6, (3), 2004, p5-10
de Carvalho, PR; Ropero, DR; Pinheiro, MM; Fernandes, PD; Boylan, F , Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant, PlosOne, 11, (10), 2016, pe0164998
Mendonça Filho, R.F.W., Menezes, F. S., Estudo da utilização de plantas medicinais pela população da Ilha Grande - RJ, Revista Brasileira de Farmacognosia, 13, 2003, p55-58
Wahab, A.; Rahayu, I; Wong, Siu Hai N.; Santos-Martinez, M J ; Boylan, F., Alkaloids from Choisya ternata and their human antiplatelet activity., Planta Medica, International Conference on Natural Products Research, New York, USA, 2012, 78, (11), 2012, pp1205-
Mantovani, I.S.B., Fernandes, S.B.O., Menezes, F.S., Constituintes apolares do fruto do açaí (Euterpe oleracea M. - Arecaceae), Revista Brasileira de Farmacognosia, 13, 2003, p41-42
Borges VRA, Tavares M, Silva JH, Tajber L, Boylan F, Ribeiro A, Nasciuti LE, Cabral L, Sousa VP, Development and characterization of poly(lactic-co-glycolic) acid nanoparticles loaded with copaiba oleoresin, Pharmaceutical Development and Technology , 23, (4), 2018, p343 - 350
Donald, GR; Fernandes PD; Boylan, F, Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil, Evidence-based Complementary and Alternative Medicine, 1, (1), 2016, p3840398-
Egan P, Stevenson PC, Wright GA, Boylan F, Stout JC, Plant toxin levels in nectar vary spatially across native and introduced populations, Journal of Ecology, 104, 2016, p1106-1115
Costa, FP; Fernandes, SBO; Fingolo, CE; Boylan, F; de Albuquerque, ACF; dos Santos Junior, FM; de Amorim, MB, Isolation, Identification, Relative Configuration and Conformational Analysis of Loliolide by GIAO-HDFT 1H and 13C NMR Chemical Shifts Calculations, Quantum Matter, 5, (5), 2016, p675 - 679
Kartbaeva, EB ; Donald, GR ; Sakipova, ZB ; Ibragimova, LN; Bekbolatova, EN ; Ternynko, II ; Fernandes, PD ; Boylan, F , Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan, Brazilian Journal of Pharmacognosy, 27, (5), 2017, p587 - 591
Leitao, GG; Pereira, JPB ; de Carvalho, PR ; Ropero, DR ; Fernandes, PD ; Boylan, F , Isolation of quinoline alkaloids from three Choisya species by high-speed countercurrent chromatography and the determination of their antioxidant capacity, Brazilian Journal of Pharmacognosy, 27, (3), 2017, p297 - 301
Sakipova, Z; Wong, NSH; Bekezhanova, T; Sadykova; Shukirbekova, A; Boylan, F , Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation, Plos One, 12, (3), 2017, pe0173714-
Sobrinho, AP; Minho, AS; Ferreira, LLC ; Martins, GR; Boylan, F; Fernandes, PD , Characterization of anti-inflammatory effect and possible mechanism of action of Tibouchina granulosa, JOURNAL OF PHARMACY AND PHARMACOLOGY, 69, (6), 2017, p706 - 713
Fernandes, F.H.A. and Boylan, F. and Salgado, H.R.N., Quality standardization of herbal medicines of Spondias dulcis Parkinson using analytical and microbiological analysis, Journal of Thermal Analysis and Calorimetry, 2018, p1-6
Bekbolatova, E. and Kukula-Koch, W. and Baj, T. and Stasiak, N. and Ibadullayeva, G. and Koch, W. and GÅ'owniak, K. and Tulemissov, S. and Sakipova, Z. and Boylan, F., Phenolic composition and antioxidant potential of different organs of Kazakh Crataegus almaatensis Pojark: A comparison with the European Crataegus oxyacantha L. flowers, Open Chemistry, 16, (1), 2018, p415-426
Izabel da Silva Hage-Melim, L. and Curtolo Poiani, J.G. and Tomich de Paula da Silva, C.H. and Boylan, F., In silico study of the mechanism of action, pharmacokinetic and toxicological properties of some N-methylanthranilates and their analogs, Food and Chemical Toxicology, 131, (110556), 2019
Di Petrillo, A. and MarÃa González-Paramás, A. and Rosa, A. and Ruggiero, V. and Boylan, F. and Kumar, A. and Pintus, F. and Santos-Buelga, C. and Fais, A. and Era, B., Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts, Journal of Enzyme Inhibition and Medicinal Chemistry, 34, (1), 2019, p519-527
Bekbolatova, E.N. and Kurbatova, N.V. and Sakipova, Z.B. and Ibragimova, L.N. and Alpysbayeva, S.I. and Kabdenova, A.T. and Kukula-Koch, W. and Boylan, F., Macroscopic and microscopic diagnostic features of the potential herbal drug crataegus almaatensis pojark endemic in Kazakhstan, Iranian Journal of Pharmaceutical Sciences, 14, (2), 2018, p39-50
Giorno, T.B.S. and dos Santos, C.H.C. and de Carvalho, M.G. and da Silva, V.C. and de Sousa, P.T. and Fernandes, P.D. and Boylan, F., Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill, Molecules, 24, (24), 2019
Soares, S.S. and Bekbolatova, E. and Cotrim, M.D. and Sakipova, Z. and Ibragimova, L. and Kukula-Koch, W. and Giorno, T.B.S. and Fernandes, P.D. and Fonseca, D.A. and Boylan, F., Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: An asian herbal medicine, Antioxidants, 8, (8), 2019
Barbosa Dos Santos, J.V. and Chaves, D.S.D.A. and Souza, M.A.A.D. and Riger, C.J. and Lambert, M.M. and Campos, D.R. and Moreira, L.O. and Siqueira, R.C.D.S. and Osorio, R.D.P. and Boylan, F. and Correia, T.R. and Coumendouros, K. and Cid, Y.P., In vitro activity of essential oils against adult and immature stages of Ctenocephalides felis felis, Parasitology, 147, (3), 2020, p340 - 347
Costa, F.L.P. and Fernandes, S.B.D.O. and Fingolo, C.E. and Boylan, F. and Mota, G.V.D.S., Tryptanthrin(indolo[2,1-b]quinazoline-6,12-dione) isolation from leaves of couroupita guianensis and its characterization by NMR experimental and GIAO-DFT data, Journal of Computational and Theoretical Nanoscience, 14, (5), 2017, p2383-2388
Silveira, D.; Pietro-Garcia, J.M.; Boylan, F.; Estrada, O.; Fonseca-Bazzo, Y.M.; Jamal, C.M.; Magalhaes, P.O.; Pereira, E.O.; Tomczyc, M. and Heinrich, M., COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?, Frontiers in Pharmacology, 11, 2020
Lambert, M.M.; Campos, D.R.; Borges, D.A.; De Avelar, B.R.; Ferreira, T.P.; Cid, Y.P.; Boylan, F.; Scott, F.B.; Chaves, D.S.D. and Coumendouros, K., Activity of Syzygium aromaticum essential oil and its main constituent eugenol in the inhibition of the development of Ctenocephalides felis felis and the control of adults, Veterinary Parasitology, 282, 2020
Sakipova, Z.; Giorno, T.B.S.; Bekezhanova, T.; Wong, N.S.H.;Shukirbekova, A.; Fernandes, P.D. and Boylan, F., Pharmacological Evaluation ofArtemisia cinaCrude CO(2)Subcritical Extract after the Removal of Santonin by Means of High Speed Countercurrent Chromatography, Molecules, 25, (12), 2020
Frontiers in Pharmacology, Switzerland, Frontiers, [eds.], 2020
Brazilian Journal of Pharmacognosy, Netherlands, Elsevier, [eds.], 2016
Fabio Boylan, Pharmacologically active derivatives of anthranilic acid occurring naturally in essential oils, 49th International Symposium on Essential Oils, Nis-Serbia, 14/09, 2018, University of Nis
Fabio Boylan, Use of phytotherapy and other CAM techniques in Veterinary Medicine in Europe: the Irish stand on this practice, VI International Symposium on Veterinary Sciences, Rio de Janeiro - Brazil, 06/11, 2018, Rural Federal University of Rio de Janeiro
Fabio Boylan, Use of phytotherapy and other CAM techniques in Veterinary Medicine in Europe: the Irish stand on this practice, VII International Symposium on Veterinary Sciences, Rio de Janeiro, 12/11, 2020, Rural Federal University of Rio de Janeiro
Fabio Boylan, Pharmacologically active derivatives of anthranilic acid occurring naturally in Essential Oils., 8th Brazilian Conference on Natural Products, Rio de Janeiro, November, 2019, Brazilian Society of Chemistry
Fabio Boylan, PROACT-URL Analysis on Medicinal Plants aiming their use to tackle Mild symptoms in Covid-19 patients, JORNADA IDEHIA IBERO-AMERICANA DE CIÊNCIAS FARMACÊUTICAS, Porto - Portugal, 6 December, 2020, Instituto Idehia
Dekic, MS ; Radulovic, NS ; Selimovic, ES ; Boylan, F , A series of esters of diastereomeric menthols: Comprehensive mass spectral libraries and gas chromatographic data, Food Chemistry, 361, 2021
Donald, GR ; de Carvalho, PR ; Fernandes, PD ; Boylan, F , Antinociceptive activity of puberulin and choisyine from ethanol extract of Choisya ternata Kunth var. Sundance, Biomedicine and Pharmacotherapy, 141, 2021
Zhang, Q ; Porto, NM ; Guilhon, CC ; Giorno, TBS ; Alviano, DS ; Agra, MD ; Fernandes, PD; Boylan, F , Pharmacognostic Study on Elsholtzia ciliata (Thumb.) Hyl: Anatomy, Phytochemistry and Pharmacological Activities, Pharmaceuticals, 14, (11), 2021
Batista, JVC ; Uecker, A ; Holandino, C ; Boylan, F ; Maier, J ; Huwyler, J ; Baumgartner, S , A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds, Frontiers in Pharmacology, 13, 2022
Benevenuto, SGM ; Domenico, MD ; Yariwake, VY ; Dias, CT ; Mendes-da-Silva, C ; Alves, ND ; Caumo, SED ; Vasconcellos, P; Morais, DR ; Cardoso, MS ; Ianicelli, J ; Waked, D; Davey, GP; Boylan, F ; Costa, JL ; Veras, MM, Prenatal exposure to Cannabis smoke induces early and lasting damage to the brain, Neurochemistry International, 160, 2022
Alsharif, B; Babington, GA; Radulovic, N ; Boylan, F , Volatiles of Capparis cartilaginea Decne. from Saudi Arabia, PLANTS-BASEL, 11, (19), 2022
Neves, NCV; de Mello, MP; Smith, SM ; Boylan, F ; Caliari, MV ; Castilho, RO, Chemical Composition and In Vitro Anti-Helicobacter pylori Activity of Campomanesia lineatifolia Ruiz & Pavon (Myrtaceae) Essential Oil, PLANTS-BASEL, 11, (15), 2022
Carolina Carvalho Guilhon, Alan Silva Minho, Marc Pouliot, Fabio Boylan and Patricia Dias Fernandes, Tibouchina granulosa Leaves Present Anti-Inflammatory Effect, Pharmaceuticals, 15, (12), 2022
Nívea Cristina Vieira Neves, Morgana Pinheiro de Mello, Isabella Zaidan, Lirlândia Pires Sousa, Alysson Vinícius Braga, Renes Resende Machado, Wirginia Kukula-Koch, Fabio Boylan, Marcelo Vidigal Caliari, Rachel Oliveira Castilho, Campomanesia lineatifolia Ruiz & Pavón (Myrtaceae): Isolation of major and minor compounds of phenolic-rich extract by high-speed countercurrent chromatography and anti-inflammatory evaluation, Journal of Ethnopharmacology, 2023
Maddison Crutcher, Alexandra Schroeder, Mackensie Wagner, Bashaer Alsharif and Fabio Boylan, 3. A review of the phytochemical properties and pharmacological uses of the genus Pistacia L. Anacardiaceae), Infarma Ciencias Farmaceuticas, 35, (3), 2023, p285 - 331
Basahaer Alsharif, Nadhim Hante, Bruna Govoni, Hugo Verli, Wirginia Kukula-Koch, Maria Jose Santos-Martinez and Fabio Boylan, Capparis cartilaginea Decne (Capparaceae): Isolation of Flavonoids by High-Speed Countercurrent Chromatography and Evaluation of their Anti-inflammatory Activity, Frontiers in Pharmacology, 14, 2023, p1285243-
Qualitative and quantitative determination of the main components of Capparis cartilaginea Decne. infusion by HPLC-UV in, Phytochemicals for Health, Elsevier, 2024, [Bashaer Alsharif and Fabio Boylan]
Fabio Boylan, Kazakhstan at the forefront of Natural Products Research, I International Asfen Forum - New Generation, 2023, Almaty, 05/06/2023, 2023, Kazakh National Medical University
Fabio Boylan, Identification of a new natural product from the essential oil of Pleurospermum austriacum (L.) Hoffm. (Apiaceae), 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Dublin, 04/07/2023, 2023, Trinity College Dublin
João V.C. Batista, Michelle Nonato de Oliveira Melo, Carla Holandino, Jakob Maier, Jörg Huwyler, Stephan Baumgartner and Fabio Boylan., 4. Characterization of Larix decidua Mill. (Pinaceae) oleoresin's essential oils composition using GC-MS, Frontiers in Plant Science, 14, 2023, p1331894-
Sonwabiso Tshunungwa, Murat Zhurinov, Bashaer Alsharif, Tolkyn Bekezhanova, Kulzada Begalinovna Bazhykova, Kayrolla Dyusenbaevich Rakhimov, Arlan Z. Abilmagzhanov, Eldar T. Talgatov, Wirginia Kukula-Koch and Fabio Boylan., Liquid Chromatography-Electrospray Ionisation-Quadrupole-Time-of-Flight Mass Spectrometry Analysis of Atemisia cina aqueous extract and the isolation of a flavonoids by the use of High-Speed Countercurrent Chromatography, Open Chemistry, 2023
Amalia Di Petrillo, Francesca Pintus, Sonia Floris, Carlo Ignazio Giovanni Tuberoso, Ana Beatriz Alcantara Bérenger Samarcos de Almeida, Thais Biondino Sardella Giorno, Patricia Dias Fernandes and Fabio Boylan., 2. Effects of Euphorbia characias flower extracts on nociceptive pain and acute inflammatory models in mice. , Fitoterapia, 2023
Niko S. Radulovi", Marko Z. Mladenovi", Clarissa Silva Lima, Elza Caroline Alves Müller, Elizabeth Vianna Moraes da Costa, Rozilene Valadares Martins and Fabio Boylan. , 1. Amazon rainforest hidden volatiles. Part I: Unveiling new compounds from Acmella oleracea (L.) R.K. Jansen essential oil. , 2023
Non-Peer-Reviewed Publications
M Gaspar, F de Sousa Menezes, MW Radomski, C Ehrhardt, Effect of liposomal systems on human platelet aggregation, AAPS J, 22nd Annual Meeting of the AAPS, Atlanta, GA, 16-20/11/2008, 10, (S2), 2008, ppT2107
Niko S. Radulovi", Marko Z. Mladenovi", Dušan R. Vuki"evi", Nikola M. Stojanovi", Pavle J. Randjelovi" , Z. Stojanovi"-Radi" and Fabio Boylan , Pulicaria dysenterica (L.) Bernh."Rightfully Earned Name? Identification and Biological Activity of New 3-Methoxycuminyl Esters from P. dysenterica Essential Oil, PLANTS-BASEL, 11, (23), 2022
Research Expertise
Description
My line of research can be summarized by: 1- The discovery of the scientific basis of natural medicines used by disadvantaged communities (poor or absent of primary health care) or communities with a strong belief in Medicinal Plants usage is a crucial point of my research. 2- The evaluation of the chemistry of Bioactive Volatile Organic Compounds (BVOCs) and their importance in food and Pharmacy became a more robust aspect of my research since my last application. 3- The discovery of harmful or even severely toxic effects from various natural medicines is constantly under scrutiny in my research. Based on recent findings of my current research in the School of Pharmacy and Pharmaceutical Sciences - TCD, the main aims for future research are outlined below. A) To investigate medicinal plants from Saudi Arabia used locally as anti-inflammatories. It aims to understand further the molecular mechanisms that explain their activities. B) A similar approach will be developed concerning Brazilian Plants I have been working with in conjunction with my Brazilian Collaborators. The aim here is to validate the popular use of Brazilian medicinal plants and their molecular interaction with biological systems. C) Continue the research developed in conjunction with the Republic of Kazakhstan. As a visiting professor at the Kazakh National Medical University, specifically in the area of Natural Products using a similar approach to the ethnopharmacological understanding of their plants, the aim is to validate endemic plants' chemical and pharmacological properties. D) St. Stephen's Green Park houses over 100 species of plants belonging to over 20 different botanical families. One of my following projects proposes the investigation of the essential oil (EO) constituents of plants growing in the park. The potential mechanism of their anticancer activity will be investigated for the EOs and EO constituents. The best candidates from those with the highest anticancer activity may be selected for further research in Pharmaceutics for their formulation using reverse micellar and silver nanoparticle production. Since my last promotion, I have published 50 research papers, with an average IF for those at 4.6 (average IF in the area of Natural Products is around 3.5). These papers were published due to the intense supervision of graduate students both in Ireland and outside of Ireland. My research is of international significance and has been widely published in academia, amongst the journals considered most favourably in the field of Pharmacy and Natural Products. I have achieved a high level of publication over a sustained period in international and peer-reviewed journals for over 15 years. According to the Researchgate database, my research interest score (2,395) is higher than 97% of scientists on the., I have authored a total of 114 publications that have had 30,367 reads and 4,327citations. My Google Scholar H-index is 28, and my i10 index is 62. I have an upward trajectory in terms of publication citation, with a peak in 2021 due to my most downloaded publication from 2020 in Frontiers in Pharmacology related to COVID-19 - 354,562 views and 15,161 downloads.Projects
- Title
- Orbignya speciosa (Arecacea) as a potencial source of novel therapeutic agents: from traditional medicine information to the pharmacological evaluation of its chemical constituents.
- Summary
- The aim of this project is to check the validity of the ethnopharmacological information for Orbignya speciosa in folk medicine. This plant is used, among other purposes, for the treatment of leukaemia and inflammatory conditions. Using modern techniques of isolation and purification of natural products and up-to-date spectroscopy techniques we aim to isolate the constituents responsible for such activities. It is also intended to test the activity for the extracts and isolates using in vivo (mice) and in vitro (cell culture) methodologies, allied to techniques in molecular pharmacology: DNA-fragmentation, electrophoresis, zymography, western-blot, apoptosis studies (flow cytometry), microscopy (SEM) among others.
- Title
- Chemical and pharmacological studies on Jambu and Piquia, two medicinal plants from the Amazon Region: development of new health products with nutraceutical and medicinal properties.
- Summary
- Acmella oleracea (Jambu) and Caryocar villosum (Piquiá) are two edible plants from the Amazon Region in Brazil. They are part of the local cuisine but also used as medicines to treat cancer. Metabolomic analysis will be employed for the study of the full chemical composition of these two species, using liquid chromatography coupled to mass spectrometry. Isolation of compounds for pharmacological assays will be performed by the use of High-Speed Counter Current Chromatography. Appropriate synthetic strategies will be used to allow for the preparation of large enough quantities of material to be assayed pharmacologically. The pharmacological activity for these two species will be also be assessed using Zebrafish methodology, and specifically the anticancer activity will be determined in cell culture using prostate, breast, intestine and lung cancer cell lines. These four cancers represent the highest incidence of mortality by cancer in Ireland. After standardisation of both chemistry and pharmacology, we envisage to prepare a formulation using modern technology for the development of a food supplement, potentially to be used as chemopreventative. As a long-term goal, we will be setting the basis for the development of a new medicine to treat symptoms associated with cancer.
- Date From
- 2021
- Title
- Chemical and Pharmacological studies on Medicinal Plants from Kazakh Flora
- Summary
- Continue the research developed in conjunction with the Republic of Kazakhstan, in the Kazakh National Medical University, specifically in the area of Natural Products aiming to help them to validate their indigenous knowledge and to try and build their own identity in terms of pharmaceutical natural products to enter in their own pharmacopoeia. So using similar approach to the ethnopharmacological knowledge of their plants, the aim is the validation of chemical and pharmacological properties of endemic plants allowing for their inclusion in the National Pharmacopoeia.
- Title
- Investigation on the anti-inflammatory properties of selected Saudi Medicinal Plants and correlation of their activity with their chemistry
- Summary
- People of Saudi Arabia and the Arabian Peninsula, in general, have been using medicinal plants to heal various routine maladies and chronic diseases including skin-related diseases, rheumatism, bone fracture, asthma, diabetes, and eye and ear problems. This unique relationship with the flora continues to this day as people still rely heavily on folklore and traditional medicine to meet their healthcare needs despite of the presence of modern hospitals and well-trained medical staff. However, these traditional practices and folklore, don't specifically present a rational and defined picture of such plants, often using many terms indiscriminately and mixing or distortion of many facts. Often the traditional medicine presents an abstract explanation and consists of imaginative information that can be misleading. Hence the need of a scientific study to evaluate those claims. In this study five medicinal plants widely used in Saudi Arabia as an analgesic and for inflammatory diseases are selected and being studied in order to assess whether the pharmacological activities that have been reported for them is in fact justifiable. The selection criteria for the plants to be studied was based on their ethnopharmacology, and their availabilities. The main aim of this study is to provide the scientific evidence for the reputed efficacy of the Saudi traditional medicinal plants Artemisia judaica, Pistacia falcata Capparis cartilaginea, Lavandula dentata, and Lavandula pubescens, in the maintenance of inflammatory conditions as possessing analgesic and anti-inflammatory activities. This study will also examine the volatile composition of two Lavandula species (dentata, and Lavandula pubescens) collected monthly for one year in order evaluate the chemical variation and establish the best time for collection for medicinal purposes and drug development. The specific objectives are: 1. To investigate extracts from A. judaica, P. falcata C. cartilaginea, L. dentata, and L. pubescens for anti-inflammatory and antinociceptive activities. 2. To isolate, purify and identify bioactive compounds from A. judaica, P. falcata C. cartilaginea, L. dentata, and L. pubescens. 3. To prepare Nano-formulations containing the plant extracts. 4. To evaluate the antinociceptive and anti-inflammatory activities of the plant extracts and isolates through formalin-induced, acetic acid-induced and hot plate models. 5. To carry out Multivariate analysis in order to characterize and compare the phytochemical constituents from L. dentata, and L. pubescens samples collected monthly. This study may be of great help for chemotaxonomic purposes, the interpretation of medicinal properties and for quality assessment of herbal supplements containing Lavandula leaves. 3. Research Questions. The main question for this research is 'Do Artemisia Judaica, Pistacia falcata Capparis cartilaginea, Lavandula dentata, and Lavandula pubescens have anti-inflammatory and antinociceptive activities? These questions are further divided into following questions; · What are the compounds responsible for the biological activities? · How effective are these natural compounds in curing the symptoms inflammatory diseases? This study will also answer the questions: · What are the major phytochemical differences between L. dentata and L. Pubescence? · Which compounds are essential for anti-inflammatory activity?
- Title
- The scents of St. Stephen's Green: would a Dublin city centre park be hiding a chemical treasure?
- Summary
- St. Stephen"s Green park houses over 100 species of plants belonging to over 20 different botanical families. This project proposes the investigation of the essential oil (EO) constituents of all plants growing in the park using two different methodologies - microwave-assisted extraction and headspace. The oil composition will be analysed via gas chromatography coupled with mass spectroscopy. In the event of unknown chemical compounds, their structures will be confirmed by means of synthesis. EOs and EO constituents will be assayed against a panel of normal and cancer cell lines. The potential mechanism of their anticancer activity will be investigated for the EOs and EO constituents using viability and proliferative cell assays, flow cytometry, ELISA and immunoblotting. The best candidates from those with the highest anticancer activity will be formulated using reverse micellar and silver nanoparticle production. The resultant successful nanoformulations will be fully characterised, and their effect will be evaluated once again in vitro
Recognition
Awards and Honours
Cum Laude Diploma
Global Relations Certificate of Excellence
Memberships
Phytochemical Society of North America
Brazilian Society of Pharmacognosy
GA - Society for Medicinal Plant and Natural Product Research