Aisling O'Halloran
Senior Research Fellow, Medical Gerontology

Biography

Dr. O'Halloran is a Senior Research Fellow with The Irish Longitudinal stuDy on Ageing (TILDA) within the academic unit of Medical Gerontology at Trinity College Dublin and Mercer's Institute for Successful Ageing (MISA) at St. James's Hospital, Dublin. She has been the research lead on both the Frailty and Biomarker Working Groups within TILDA and also manages the TILDA Biobank, the largest of its kind in the Rep. of Ireland. Dr. O'Halloran holds a PhD in the genetic epidemiology of cardiovascular disease from the Royal College of Surgeons in Ireland and a B.A. (Mod) in Natural Science, specializing in genetics, from Trinity College Dublin. For over ten years, Dr. O'Halloran has conducted research on studies of ageing, health epidemiology, immunology and genetics. Her research interests are in the area of frailty and ageing biology in older adults, including related risk factors (biomarkers) and patterns of service use. She has secured a combined peer-reviewed grant portfolio of >€500K, including a CARDI Leadership in Ageing Research fellowship. She has published >20 peer-reviewed articles in international journals. Dr. O'Halloran is also a member of the Executive Committee of the Irish Gerontological Society (IGS) and Associate Editor with the international open access journal BMC Geriatrics.

Publications and Further Research Outputs

Peer-Reviewed Publications

Fiorito, G., Polidoro, S. Dugue, P.A., Kivimaki, M., Ponzi, E., Matullo, G., Guarrera, S., Assummaa, M.B. Georgiadis, P., Kyrtopoulos, S.O. Krogh, V. Palli, D., Panico, S., Sacerdote, C. Tumino, R., Chadeau-Hyam, M., Stringhini, S., Severi, G., Hodge, A.M., Giles, G.G., Marioni, R., Linnér, R.K. O'Halloran, A., Kenny, R.A., Layte, R., McCrory, C., Baglietto, L., Milne, R.L., Vineis, P. (2017)., Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation., Scientific Reports, 7, (1), 2017, p16391 - 16395 Journal Article, 2017 URL DOI

Laird E, O'Halloran AM, Carey D, Healy M, O'Connor D, Moore P, Shannon T, Molloy AM, Kenny RA., The prevalence of vitamin D deficiency and the determinants of 25(OH)D concentration in older Irish adults: Data from The Irish Longitudinal Study on Ageing (TILDA)., The journals of gerontology. Series A, Biological sciences and medical sciences, 2017 Journal Article, 2017 DOI

Moran R, Beatty S, Stack J, O'Halloran AM, Feeney J, Akuffo KO, Peto T, Kenny RA, Nolan JM., The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample., Current eye research, 2017, p383-390 Journal Article, 2017 DOI

Roe LD, Normand C, Wren MA, Browne J, O'Halloran AM., The impact of frailty on healthcare utilisation in Ireland: evidence from the Irish Longitudinal Study on Ageing. , BMC Geriatrics, 17, (203), 2017 Journal Article, 2017 DOI

Feeney J, O'Leary N, Moran R, O'Halloran AM, Nolan JM, Beatty S, Young IS, Kenny RA. , Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging., The journals of gerontology. Series A, Biological sciences and medical sciences, Jan, 2017, p1-6 Journal Article, 2017 URL DOI

Moran R, Nolan J.M, Stack J, O'Halloran A.M, Feeney J, Akuffo K.O, Kenny R.A, Beatty S, Non-dietary correlates and determinants of plasma lutein and zeaxanthin concentrations in the Irish population, The journal of nutrition, health & aging, 21, (3), 2017, p254 - 261 Journal Article, 2017 URL DOI

Murphy C, Shelley E, O Halloran AM, Fahey T, Kenny RA. , Failure to control hypercholesterolaemia in the Irish adult population: Cross-sectional analysis of the baseline wave of The Irish Longitudinal Study on Ageing (TILDA). , Irish Journal of Medical Science, 2017, p1-9 Journal Article, 2017 DOI TARA - Full Text URL

Leahy S, O' Halloran AM, O' Leary N, Healy M, McCormack M, Kenny RA, O' Connell J., Prevalence and correlates of diagnosed and undiagnosed type 2 diabetes mellitus and pre-diabetes in older adults: Findings from the Irish Longitudinal Study on Ageing (TILDA)., Diabetes research and clinical practice., 110, (3), 2015, p241 - 249 Journal Article, 2015 URL DOI

Theou O, O'Connell MDL, King-Kallimanis BL, O'Halloran AM, Rockwood K, Kenny RA., Measuring Frailty using Self-report and Test-based Health Measures., Age and Aging, 44, (3), 2015, p471-7 Journal Article, 2015 DOI TARA - Full Text

Peklar J, O'Halloran AM, Maidment ID, Henman MC, Kenny RA, Kos M. , Sedative load and frailty among community-dwelling population aged ≥65 years. , Journal of the American Medical Directors Association, 16, (4), 2014, p282 - 289 Journal Article, 2014 DOI

Owusu Akuffo K, Nolan J, Stack J,Moran R, Feeney J,Kenny RA, Peto T, Dooley C, O'Halloran AM, Cronin C, and Beatty S. , Prevalence of age-related macular degeneration in the Republic of Ireland. , British Journal of Ophthalmology, 99, 2015, p1037-1044 Journal Article, 2015 DOI TARA - Full Text

Greene BR, Doheny EP, O'Halloran AM, Kenny RA., Frailty status can be accurately assessed using inertial sensors and the TUG test. , Age and Ageing, 43, (3), 2014, p406 - 411 Journal Article, 2014 URL TARA - Full Text DOI

O'Halloran AM, Finucane C, Savva GM, Robertson IH, Kenny RA., Sustained Attention and Frailty in the Older Adult Population., Journals of Gerontology B Psychological Sciences and Social Sciences. , 69, (2), 2014, p147 - 155 Journal Article, 2014 DOI

O'Halloran AM, Kenny, RA, King-Kallimanis BL. , The latent factors of depression from the short forms of the CES-D are consistent, reliable and valid in community-living older adults. , European Geriatric Medicine, 5, (2), 2014, 97-102 Journal Article, 2014 TARA - Full Text DOI

O'Halloran AM, Fan CW, Kenny RA, Pénard N, Galli A, Robertson IH., Variability in sustained attention and risk of frailty., Journal of the American Geriatric Society, 59, (12), 2011, p2390 - 2392 Journal Article, 2011 DOI URL

O'Halloran AM, Pénard N, Galli A, Fan CW, Robertson IH, Kenny RA, Falls and falls efficacy: the role of sustained attention in older adults., BMC geriatrics, 11, (85), 2011, p10 Journal Article, 2011 DOI TARA - Full Text URL

Ryan MT, O'Halloran AM, Hamill, RM, Davey, GC, Gil M, Southwood OI, Sweeney T. , Polymorphisms in the regulatory region of the porcine MYLPF gene are related to meat 3 quality traits in the Large White breed., Meat Science, 113, 2016, p104 - 106 Journal Article, 2016 URL DOI

Sweeney T, O'Halloran AM, Hamill RM, Davey GC, Gil M, Southwood OI, Ryan MT., . Novel variation in the FABP3 promoter and its association with fatness traits in pigs., Meat Science, (100), 2014, p32 - 40 Journal Article, 2014 DOI

Ryan MT, Hamill RM, O'Halloran AM, Davey GC, McBryan J, Mullen AM, McGee C, Gispert M, Southwood OI, Sweeney T, SNP variation in the promoter of the PRKAG3 gene and association with meat quality traits in pig., BMC Genetics, 13, (66), 2012, p17 Journal Article, 2012 TARA - Full Text URL DOI

O'Halloran AM, Patterson CC, Horan P, Maree A, Curtin R, Stanton A, McKeown PP, Shields DC., Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2)., Journal of Thrombosis and Thrombolysis, 27, (2), 2009, p175 - 184 Journal Article, 2009 URL DOI

O'Halloran AM, Curtin R, O'Connor F, Dooley M, Fitzgerald A, O'Brien JK, Fitzgerald DJ, Shields DC., The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets., British Journal of Haematology, 132, (4), 2006, p494 - 502 Journal Article, 2006 DOI URL

O'Halloran AM, Stanton A, O'Brien E, Shields DC., The impact on coronary artery disease of common polymorphisms known to modulate responses to pathogens., Annals of Human Genetics, 70, (6), 2006, p934 - 945 Journal Article, 2006 URL DOI

Dolan C, O'Halloran A, Bradley DG, Croke DT, Evans A, O'Brien JK, Dicker P, Shields DC., Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population., European Journal of Human Genetics, 13, (7), 2005, p798 - 806 Journal Article, 2005 DOI

Shields DC, O'Halloran AM., Integrating genotypic data with transcriptomic and proteomic data., Comparative and Functional Genomics, 3, (1), 2002, p22 - 27 Review Article, 2002 TARA - Full Text URL DOI

O'Halloran AM, Laird EA, Healy M, Moran R, Nolan J et al, CIRCULATING BIOMARKERS PREDICT INCIDENT FRAILTY: THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA) , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp23 - 23 Published Abstract, 2017 DOI

Donoghue O, Setti A, O'Leary N, O'Halloran AM, Kenny R., SELF-REPORTED UNSTEADINESS PREDICTS FEAR-RELATED ACTIVITY RESTRICTION AT TWO YEARS FOLLOW-UP , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp927 - 928 Published Abstract, 2017 DOI

Roe LD, O'Halloran AM, Kenny R, Normand C., SUPPORTING OLDER PEOPLE TO AGE IN PLACE IN IRELAND: FRAILTY-RELATED HEALTH CARE USE AND OUTCOMES , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp1056 - 1056 Published Abstract, 2017 DOI

O'Halloran AM, Laird E, Healy M, Moran R, Beatty S, Nolan J, Molloy AM, Kenny RA. , Circulating Blood Biomarkers In Older Adults With Frailty: The Irish Longitudinal Study on Ageing (TILDA)., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 DOI URL

O'Halloran AM, Laird E, Healy M, Moran R, Beatty S, Nolan J, Molloy AM, Kenny RA., Prevalence Of Micronutrient, Inflammatory Stress, Metabolic And Renal Conditions In Frail Older Adults: The Irish Longitudinal Study on Ageing (TILDA). , Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 URL DOI

Moran R, Nolan J, Stack J, O'Halloran AM, Feeney J, Akuffo KO, Kenny RA, Beatty S. , Relationship Between Prevalence (And Awareness)Of Age-Related Macular Degeneration And Plasma Concentrations Of Lutein And Zeaxanthin In An Older Population., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 DOI URL

Roe L, O'Halloran AM, Normand C., The Evaluation of the Older People Remaining At Home (Oprah) Project: A Mixed Methods Study., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii1 - ii12 Published Abstract, 2016 DOI URL

O'Halloran AM, Roe L, Kenny RA and Normand C., The impact of different measures of frailty on rates of health service use among the community dwelling elderly., Journal of Frailty and Aging, 3rd International Congress of Frailty and Sarcopenia Research (ICFSR), Boston, USA, 23-25 April, 4, (S1), 2015, pp46- Published Abstract, 2015

O'Halloran AM, Bressan J, King-Kallimanis BL, O'Connell MDL, Fagan J, Keenan E, Barry J, Kenny RA. , Frailty Is A Marker of Premature Biological Ageing: Preliminary Evidence from The Irish Longitudinal Study of Ageing and a Community-based Methadone Treatment Program., Journal of Frailty and Aging, 3rd International Congress of Frailty and Sarcopenia Research (ICFSR), Boston, USA, 23-25 April, 4, (S1), 2015, pp79- Published Abstract, 2015

O'Halloran AM, King-Kallimanis BL, O'Connell MDL, Robertson IH, and Kenny RA., Sustained attention correlates with two models of frailty At baseline and follow-up: the irish longitudinal study of ageing., Journal of Frailty and Aging, International Conference of Frailty and Sarcopenia Research, Barcelona, Spain, March 12-14, edited by Cesari M , 3, (1), Serdi Edition, 2014, pp34 - 34 Published Abstract, 2014 URL TARA - Full Text

Peklar, J, O'Halloran AM, Kos M, Henman MC, Maidment I, Kenny RA, Frailty syndrome and sedative load of drugs, Journal of Frailty and Aging, International Conference on Frailty and Sarcopenia Research, Barcelona, Spain, March 12-14, edited by Cesari M , 3, (1), Serdi Edition, 2014, pp54 - 54 Published Abstract, 2014 TARA - Full Text URL

O'Halloran, A.M., Finucane, C., Savva, G.M., Robertson, I.H., Kenny, R.A. , Sustained attention and frailty in the older adult population, Journals of Gerontology - Series B Psychological Sciences and Social Sciences, 69, (2), 2014, p147-156 Journal Article, 2014 DOI

O'Halloran, A.M., Kenny, R.A., King-Kallimanis, B.L., The Factor Structure of the Long and Short Forms of the CES-D Scale and the Validity of Positive Affect in Older Irish Adults., Age and Ageing, British Geriatric Society (BGS), Spring Meeting, Belfast, UK, April 18-19, 2013, edited by Stott, DJ , 45, (S3), Oxford Journals, 2013, ppii27- Published Abstract, 2013 URL URL TARA - Full Text

O'Halloran, A.M., Kallimanis, B.L., Kenny, R.A. , The Impact of Positive Affect on Falls and Fear of Falling in the Older Adult Population. , Age and Ageing, British Geriatric Society (BGS), Annual Meeting, Harrogate, UK, November 28-30, 2012, edited by Stott, DJ , 42, (S2), Oxford Journals, 2013, ppii20- Published Abstract, 2013 URL TARA - Full Text

O'Halloran, A.M., O'Connell, M.D.L., Finucane, C., Savva, G.M., Robertson, I.H., Kenny, R.A. , The Relationships Between Executive Function, Cognitive Processing Speed And Two Models of Frailty Are Mediated By Sustained Attention In The Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Venice, Italy, October 2-4, edited by Michel, J-P , 4, (S1), Elsevier, 2013, ppS70- Published Abstract, 2013 URL TARA - Full Text

O'Halloran, A.M., Treacy, K., Cunningham, C., Crosby, L., Walsh, C., Fan, C.W., Kenny, R.A. , The Impact of Positive Affect on Falls Efficacy in the Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Brussels, Belgium, September 26-28, edited by Michel, J-P , 3, (S1), Serdi Edition, 2012, ppS137- Published Abstract, 2012 URL TARA - Full Text URL

O'Halloran, A.M., Finucane, C., Savva, G.M., Robertson, I.H., Kenny, R.A. , Sustained Attention Is Associated With Frailty In The Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Brussels, Belgium, September 26-28, edited by Michel, J-P , 3, (S1), Serdi Edition, 2012, ppS16- Published Abstract, 2012 TARA - Full Text URL

Non-Peer-Reviewed Publications

O'Halloran, AM, Recognising Frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA)., : Integrated Care Approach for Frailty in the Older Person Conference. , Galway, Ireland, March 8th , 2017, Health Service Executive and Saolta Hospital Group, 1pp Invited Talk, 2017

Roe L, O'Halloran AM, Normand C, Murphy C., The impact of frailty on public health nurse service utilisation. Findings from The Irish Longitudinal Study on Ageing (TILDA). , Dublin, Ireland, The Irish Longitudinal Study on Ageing., September, 2016, 1-28 Report, 2016 URL

Aisling M. O'Halloran, Falls and Frailty in Ireland - Evidence from the Irish Longitudinal Study on Ageing (TILDA), AGM of Chartered Physiotherapists of Ireland in Neurology and Gerontology, Dublin, Ireland, May 17, 2014, Chartered Physiotherapists of Ireland Invited Talk, 2014

Aisling O'Halloran, Mature Matters: Ageing, 2012, - 1 Miscellaneous, 2012 URL TARA - Full Text

Research Expertise

Description

Her current research interest is in the biology of ageing, including frailty, falls, resilience and well-being. She has a particular interest in characterizing biomarkers (genes, proteins, metabolites, processes) implicated in these age-related disorders. The goal of her research is to identify early biomarkers for use in screening and intervention in the progression of frailty and investigate patterns of health care use. This work will inform frailty detection/prevention/intervention, frailty-related health service use and provision and raise public awareness of frailty on the island of Ireland.

Projects

  • Title
    • Frailty in Ireland North and South
  • Summary
    • The unprecedented global increase in life expectancy over the past century has lead to a rapidly expanding ageing population, placing ever higher demands on publicly-funded healthcare resources in Ireland, North and South. Current trajectories indicate that such demands are unsustainable. Early identifiers of declining health will be central to measuring health risk. The European Innovation Partnership on Active and Healthy Ageing has highlighted frailty as key to seeking a two year increase in healthy life years by 2020. Resilience and frailty represent opposite ends of a spectrum of decline from robust health to profound functional dependence. Frailty is a driver of functional and cognitive decline, predicting multi-morbidity, disability, increased health care utilisation and mortality (Fried et al, 2001, 2004). However, frailty can be ameliorated by early detection and intervention. Data from The Irish Longitudinal Study of Ageing (TILDA) will be used to track transitions along the frailty spectrum and investigate how frailty-related biomarker profiles of physical, cognitive and psychological health at baseline (Wave 1) change and predict frailty during follow-up (Waves 2 and 3). North-South comparisons between the prevalence and characteristics of frailty using Wave 3 of TILDA and Phase 1 of the Northern Ireland Cohort for Longitudinal Ageing (NICOLA), which coincide during 2014. Will be performed. Elucidating frailty-related risk factors and resource demands in the ageing population will help to identify: (1) new evidence-based targets for pre-clinical frailty detection and intervention, and (2) specific needs that will be vital in delivering efficient, effective healthcare services and increasing healthy life-years into the future
  • Funding Agency
    • CARDI - Centre for Ageing Research in Ireland
  • Date From
    • March 2014
  • Date To
    • February 2017

Keywords

AFFECT; Age related diseases; Ageing; Ageing, memory and other cognitive processes; Ageing, stroke, dementia; Aging/Gerontology; Brain; Cardiovascular Diseases; Cardiovascular System; Elderly Health; Emotional/Mental Health--Geriatric; Epidemiology; Falls; Frailty & Resilience; Gerontology; Positive Ageing; Psychology of Aging; Quantitative genetics and genetics of complex traits

Recognition

Awards and Honours

Best Abstract Award at Falls Frailty and Bone Health Europe Conference, Dublin. 10/11/2017

Best Presentation Medal at Irish Gerontological Society Annual Scientific Meeting, Kilarney 01/10/2016

CARDI Ageing Research Leadership March 2014

Department of Agriculture Fisheries and the Marine (DAFM) FIRM/RSF/CoFoRD 2013 Research Award December 2013

Best Research Presentation. Medical Gerontology Annual Research Meeting, Trinity College, Dublin March 2012

Commendation Award for Scientific Presentation at Irish Gerontological Society Annual (IGS) Scientific Meeting, Dublin September 2011

America-Ireland Fund Undergraduate Scholarship Award, Smurfit Institute of Genetics, Trinity College Dublin and School of Medicine, Washington University, St. Louis, Missouri, USA May 1998

Memberships

Irish Gerontological Society Member of Executive Committee (2016 - present) 2010- – present

British Geriatrics Society (BGS) 2012-

European Union Geriatric Medicine Society (EUGMS) 2012-

National Institute of Ageing (NIA) Biomarker Network. 2013-

Irish Society of Immunology 2012-