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Latest Discoveries & Publications

 Alarm Clock Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease. Time of day affects severity of autoimmune disease. In the new study, Professor Kingston Mills and Dr Caroline Sutton of Trinity College Dublin, and Dr Annie Curtis of RCSI (Royal College of Surgeons Ireland), and colleagues show that immune responses and regulation of autoimmunity are affected by the time of the day when the immune response is activated. Nature communications   TCD press


 Andrew Bowie Andrew Bowie's paper out today 7 December 2017 in Nature Communications explaining how Malaria DNA triggers innate immune sensors - collaboration between TCD and Weizmann. Professor in Immunology at TBSI Andrew Bowie, said of the new research: "When our immune system responds to pathogens such as malaria, it's a double-edged sword. The wrong kind of response can actually favour the pathogen and lead to more harm than good. And it seems that malaria parasites actually switch on an immune response to their own DNA to survive longer." "Here we found the switch mechanism for this, an immune sensor called STING, which senses DNA from the malaria nanovesicles when it is delivered into monocytes. Through STING, malaria parasites fool the immune system into inappropriate responses that favour the parasite's survival." Nature paper


 Richie Porter Plusvital Launches the World's First Nutrigenomic Supplement for Horses In research funded by SFI and published this week, scientists at University College Dublin and Trinity College Dublin, have shown that the genetic background of a horse has a significant influence on the production of CoQ10 in horse muscle cells. Collaborating scientist TBSI's Professor Richard Porter, School of Biochemistry and Immunology said, "Mitochondrial function is clearly an important variable in equine performance. Our research has shown that efficiency in mitochondrial function has a genetic basis in the horse and that this information can now be applied in practice." Thoroughbred Daily Irish Tech News TCD press

 Orla Hardiman  Researchers combine EEG and MRI to monitor brain changes. new technology to find improved ways of understanding MND These findings were published in the recent issue of the journal Cerebral Cortex and the reader can also see a report wrtten by TCD press 



 cubicon protocol  The Cubicon Method developed in the Membrane Structural & Functional Biology Group provides a rationally designed, simple solution with applications in structural biology, ligand screening, drug delivery, antibody production and protein complex formation NATURE PROTOCOLS | 12 | 1745 | 2017

 Blood Vessel Discovery of rogue messengers  Research led by Professor Lorraine O'Driscoll at the School of Pharmacy & Pharmaceutical Sciences, TBSI has made a discovery around treatment-resistant breast cancer. Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles. Journal OncoImmunology, August 2017 TCD press. 

Finlay Lab Nature Immunology paper published today 18 September 2017. Scientists have just discovered how the engine that powers cancer-killing cells functions. Crucially, their research also highlights how that engine is fuelled and that cholesterol-like molecules, called oxysterols, act as a "cut-off" switch making it hard for our Natural Killer cells to win the war against cancer. The scientists, led by Ussher Assistant Professor in Immunometabolism at TBSI, Dr David Finlay, have just published their findings in leading journal Nature Immunology They report a previously unknown metabolic switch, which is essential for initiating the anti-tumour actions of Natural Killer cells.  

Padraic Fallon Breakthrough that could Lead to New Treatments for Asthma and Eczema. The team of scientists was led by Science Foundation Ireland Stokes Professor of Translational Immunology, Padraic Fallon, of the School of Medicine in the Trinity Biomedical Sciences Institute. In a press statement, TBSI'S Padraic Fallon said the discovery "has important implications for the development of new therapeutic approaches for asthma and other allergic diseases". JEM  

creating a lipoprotein Congratulations to the Membrane Structural & Functional Biology Group on the publication of their article in Nature Communications. Lipoproteins serve essential roles in the bacterial cell envelope. They are molecular fingerprints by which our immune system recognizes and responds to bacterial infections. The enzymes that synthesise lipoproteins are potential targets for the development of urgently needed new antibiotics. The high-resolution structure of one of these enzymes, Lnt, is reported here. It can now be used to understand how Lnt works at a molecular level as a nanomachine and for the design and discovery of new antibiotics with minimal off-target effects. "Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis" Nat. Commun. 10.1038/NCOMMS15952, 2017  

David Finlay David Finlay, TBSI's Assistant Professor of Cancer Biology &Therapeutics:  "The discovery that T Cells and dendritic cells compete with each other for glucose offers a new and exciting insight into how glucose can regulate dendritic cell function". Nature Communications article 30 May 2017


Discoveries prior to those listed above

News & Events

 Luke O'Neill

Congratulations to Luke O'Neill who won the overall Provost Innovation Award 2017! TCD press

 Rachel McLoughlin

Key Leaders in the Irish Research Community recognised by Science Foundation Ireland at the 2017 Science Summit Awards. The SFI Early Career Researcher Award recognises outstanding early career research talent. Recipient: Dr Rachel McLoughlin, TBSI. Dr Rachel McLoughlin is recognised internationally as a leading researcher in Staphylococcus aureus host pathogen interactions. SFI news

 Lorraine O'Driscoll

H2020 Marie Sklodowska-Curie Innovation Training Network TBSI's Lorraine O'Driscoll has been awarded almost 4 million euro Horizon 2020 funding for a programme entitled "Training in Extracellular vesicles for benefit in Health and Disease". The Programme will train 15 PhD students over its 4-year lifetime and will work on establishing standards and best practice for exosomes and other extracellular vesicles (EVs) research. TCD Press

 Martin Caffrey   Kingston Mills  Andrew Bowie Congratulations to TBSI's Martin Caffrey, Kingston Mills, Andrew Bowie on their success as Minister John Halligan announces research investment of 43 million euro through SFI Investigators Programme SFI news

 Andrew Bowie  Professor Andrew Bowie (School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, TCD) is the 2017 recipient of the ISI Public Lecture Award, which will be hosted on 27th April in association with the Irish Times. A public lecture will take place in the Tercentenary Hall, Floor 2, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2. at 7.00 pm on Thursday, 27th April 2017. (Doors will open for the event from 6.30pm and no pre-booking of tickets is required) This lecture will also mark part of the ISI's contribution to the European Day of Immunology 2017 Bio .pdf 371.kb

News and Events prior to those listed above

Last updated 13 December 2017 by Caroline Levis (Email).