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Contact:
Prof. Martin Hegner
CRANN - the Naughton institute
School of Physics
Trinity College Dublin
Dublin 2
Ireland

Phone: +353-1-8962285
Fax: +353-1-8963037
email: martin.hegner@tcd.ie

THE NANOMECHANICS PROJECT

SINGLE MOLECULE MANIPULATION AND BIOSENSING USING SCANNING PROBE MICROSCOPY OR OPTICAL TWEEZERS

CRANNOur research focuses on the dynamics and kinetics of interacting biomolecules, the mechanics of protein filaments and the DNA/RNA transport through pores of nano-containers and biological membranes. We develop state of the art combined force- and light spectroscopy tweezers instruments and are also leaders in the development of cantilever array devices and taylor made bio-engineered nano-mechanical biosensors for genomics, proteomics, microbio (environmental) and chemical sensing applications.
A team of 9 researchers (Physics, Molecular Biology, Microbiology, Nanoscale Science) under the guidance of Martin Hegner is currently developing the next generation of nano-mechanical sensors.
The tools we use are Scanning Force Microscopy (SFM) and Optical Tweezers (OT) and cantilever array sensors (NOSE) and all instrumentation required for surface analysis and modification.

Sensing Tools for Nano-Systems investigations

 

Sensing Tools for Macro-Systems investigations

 

Nanomechanical sensing meeting 2011

Optical Tweezers

Scanning Force Microscopy

Nanomechanical Cantilever Arrays

 

NEW Job Opportunities!!

optical tweezers scanning force microscopy cantilever arrays    
Force resolution 0.1 pN - 200pN
Force resolution 10 pN - 4nN
pN Interaction Forces transduced into nanomechanical motion
 

Newest paper of the team

Projects:Single Molecule mechanics and spectroscopy:
Current highlights: VirE2 dynamics, dsDNA Mechanics, Mitochondria import, Ribosomal mechanics

Projects:Single Molecule mechanics and spectroscopy:
recent project: Nanomechanical Protein Folding

Projects: Gene fishing, Proteomics sensors, Microorganism sensors, Membrane protein sensors, Ion sensors, Gas sensors.
Current highlight: Tiny Springboards detect Viruses in Fluids

 

OpenDay School of Physics Slides MH

last updated: October 22, 2010 - Webmaster