Biography
Dr Langan is a Consultant in Clinical Neurophysiology in St James's Hospital. She undertook clinical training in Neurology and Neurophysiology in Dublin, London and Newcastle upon Tyne. She spent three years in the Department of Experimental Epileptology in the Institute of Neurology in Queen Square, London, undertaking research into Sudden Unexpected Death in Epilepsy (SUDEP). Dr Langan continues to be involved in research into SUDEP along with projects involving EEG and peripheral neurophysiology. She is President of the Irish Society of Clinical Neurophysiology and is active in teaching at undergraduate and postgraduate level.
Publications and Further Research Outputs
Peer-Reviewed Publications
Langan Y., Lynn E., The incidence of sudden unexpected death in epilepsy (SUDEP) in the Republic of Ireland, Seizure, 122, 2024, p34 - 38, p34-38
McKenna MC, O'Connor A, Lockhart A, Bogdanova-Mihaylova P, Brett F, Langan Y, Meaney J, Costigan D, Doherty CP, Bede P, Murphy SM, Hutchinson S., POLR3A-related disorders: expanding the clinical phenotype., J Neurol., 2024
McGonigle O., Russell C., Langan Y., Advice following a possible first seizure: what do patients attending for EEG remember?, Seizure, 113, 2023, p19 - 22, p19-22
Bergin P, Langan Y, Beghi E, Donner E, Cock H, D'Souza W, Thomas R, Scragg R, Invitiation to participate in a prospective case control study of sudden unexpected death in epilepsy, Epilepsia, 62, (5), 2021, p1280 - 1281
Togher Z, Redmond A, Troy E, Penugonda M, Crumlish N, Langan Y, Hutchinson S., A case of Urbach Wiethe disease asssociated with ictal fear, Neurology, American Academy of Neurology, Toronto, 2020, 2021
Al Bayati F, McGrane C, Sweeney A, Langan Y., The role of ambulatory EEG in the investigation of paroxysmal events, Irish Medical Journal, 114, (3), 2021, p304 - 304
McKenna MC, Al-Hinai M, Bradley D, Doran E, Hunt I, Hutchinson S, Langan Y, O'Rourke D, Qasem R, Redmond J, Troy E, Doherty CP., Patients' Experiences of Remote Neurology Consultations during the COVID-19 Pandemic, European Neurology, 83, (6), 2021, p622 - 625
O Donnell M, Hunt I, McKenna MC, Armstrong C, Flynn C, Leonard N, Cryan J, Langan Y Redmond J., When you cannot 'keep your chin up'. An unusual case of head drop., Irish Neurological Association, virtual, October 2020, 2020
Moloney PB, Hutchinson S, Heskin J, Mulcahy F, Langan Y, Conlon NP, Linas BP, Takashi C, Cervantes-Arslanian AM., Possible N methyl D asparatate receptor antibody mediated encephalitis in the setting of HIV cerebrospinal escape., Journal of Neurology, 267, (5), 2020, p1348 - 1352
Fearon C, Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J., Very-late-onset Friedreich's ataxia: Diagnosis in a kindred with late-onset cerebellar ataxia, Practical Neurology, 1, (20), 2020, p55 - 58
Moloney P, Heskin J, Langan Y, Conlon NP, Mulcahy F, Hutchinson S, NMDAR encepalitis associated with HIV CNS escape., American Academy of Neurology, Philadelphia, April 2019, 2019
Chalissery AJ, Munteanu T, Langan Y, Brett F, Redmond J., Diverse phenotype of hypokalaemic periodic paralysis within a family, Practical Neurology, 18, (1), 2018, p60 - 65
Brett F, Chen D, Loftus T, Langan Y, Looby S, Hutchinson S, Intravascular large B cell lymphoma presenting clinically as rapidly progressive dementia., Irish Journal of Medical Science, 187, (2), 2018, p319 - 322
Lynn E, Lyons S, Langan Y, Craig S, Doherty C, The role of alcohol dependency in deaths among people with epilepsy recorded by the National Drug-Related Deaths Index (NDRDI) in Ireland, 2004-2013, Seizure, 45, 2017, p52 - 55
Monaghan B, Chalissery A, Brett F, Langan Y, Redmond J., Congenital myasthenic syndrome presenting in the sixth decade, American Academy of Neurology, Boston, 2017, 2017
Canavan J, Langan Y, Epilepsy mortality in Ireland, Irish Neurological Association , Limerick, May 2016, 2016
Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J., Diagnosis of Friedrich's Ataxia in late onset progressive cerebellar ataxia, Neurology, American Academy of Neurology, Washington DC, April 2015, 84, (14), 2015
E.Kelleher, P.McNamara, B. Fitzmaurice, R.Walsh, Y.Langan, P.Whitty, M.Gill, A.Vincent, C.Doherty, A.Corvin, Prevalence Rate of N-methyl-d-aspartate (NMDA) Receptor Antibodies in First Episode Psychosis, European Psychiatry, 23rd European Congress of Psychiatry, Vienna, 28-31 March 2015, 30, (Supp 1), Science Direct, 2015, pp1568-
O Dowd S, Munteau T, Hardiman D, Langan Y, Brett F, Redmond J., Ockham's razor of Hickham's dictum? The diagnostic journey of a patient with proximal myopathy, Association of British Neurologists, 2015
Munteau T, Redmond J, Langan Y, Brett F, Periodic muscle paralysis- a different perspective, American Academy of Neurology, Washington DC, April 2015, 2015
Donohue F, Doherty C, Langan Y, White M, Morrow S, White M, Hayes CB , Mortality from SUDEP and Status Epilepticus in Ireland, Irish Medical Journal, 106, (3), 2013, p91 - 92
Donohue, F., Doherty, C., Langan, Y., White, M., White, M., Morrow, S., Hayes, C., Mortality due to sudep and status epilepticus, Irish Medical Journal, 106, (3), 2013, p1-2
Laffan A, Langan Y, Understanding EEG indications and reports: a survey of NCHDs, Irish Medical Journal, 106, (2), 2013, p59 - 60
Iqbal M, Connolly S, Langan Y, Redmond J., A case of Lambert-Eaton myasthenic syndrome with possible myasthenia gravis, Irish Medical Journal, 105, 2012, p183 - 184
Lamberts RJ, Thjis Rd, Laffan A., Langan Y, Sander JW, Sudden unexpected death in epilepsy:people with nocturnal seizures may be at highest risk, Epilepsia, 53, (2), 2012, p253 - 257
O'Connor G, Bradley D, McNamara P, Connolly S, Langan Y, Redmond J., Late-onset CMT phenotype caused by a novel mutation in the MPZ gene, European Journal of Neurology, 19, 2012, p65 - 66
Hersdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A., ILAE Commission on Epidemiology; subcommission on mortality. Do antiepileptic drugs or tonic clonic seizure frequency increase SUDEP risk?, Epilepsia, 53, (2), 2012, p249 - 252
Hersdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A., ILAE Commission on Epidemiology; subcommission on mortality. Combined analysis of risk factors for SUDEP., Epilepsia, 52, (6), 2011, p1150 - 1159
O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, EEG findings in vasovagal syncope, Irish Gerontological Society, 2011
McNamara PH, Costelloe L, Langan Y, Redmond J., Aquaporin-4 seropositivity in a patient with coeliac disease but normal neurological examination and imaging, Journal of Neurology, 258, 2011, p702 - 703
O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, Electroencephalographic findings in different age groups with vasovagal syncope, Journal of Cardiovascular Electrophysiology, Venice Arrhythmias 2011, Venice, 2011, 2011
C O'Dwyer, K Bennett, Y Langan, CW Fan, RA Kenny., Amnesia for loss of consciousness is common in vasovagal syncope., Europace, 13, (7), 2011, p1040 - 1045
O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, Does amnesia for loss of consciousness occur with vasovagal syncope?, Journal of Cardiovascular Electrophysiology, Venice Arrhythmias 2011, Venice, 2011
Lambert RJ, Laffan A, Thijs RD, Sander JW, Langan Y, Circadian seizure patterns in SUDEP: Patients with nocturnal seizures are at highest risk., Epilepsia, 29th International Epilepsy Congress, Rome, 52, (6), 2011, pp4 - 22
McNamara PH, Costelloe L, Langan Y, Redmond J., Anti-Yo positive dorsal root ganglionopathy, Journal of Neurology, 258, 2010, p1400 - 1401
Langan Y, Nashef L, Sander JWAS, Case control study of SUDEP, Neurology, 64, (7), 2005, p1131 - 1133
Sudden unexpected death in epilepsy in, editor(s)S Shorvon, D Fish, E Dodson, E Perucca , Epilepsy Treatment 2nd Edition, UK, Oxford: Blackwell, 2004, pp43 - 49, [Langan Y, Nashef L.]
Langan Y, Gholkar A, Ellison D, Jenkins A, Schofield I, Lai M., New onset non-epileptic attacks after successful epilepsy surgery., Association of British Neurologists, London, March 2004, 2004
Langan Y, Nashef L., Sudden unexpected death in epilepsy, Advances in Clinical Neuroscience and Rehabilitation, 2, 2003, p6 - 8
Langan Y, Lucas R, Jewell H, Toublanc N, Schaefer H, Sander JW, Patsalos P., Talamapanel, a new antiepileptic drug: single and multiple does pharmacokinetics and initial one week experience in patients with chronic intractable epilepsy, Epilepsia, 44, (1), 2003, p46 - 53
Langan Y, Nashef L, Sander JWAS, Prevention of sudden unexpected death in epilepsy, Journal of Neurology, Neurosurgery and Psychiatry, Association of British Neurologists , Cape Town, January 2003, 2003
Langan Y, Nashef L, Sander JWAS, Certification of deaths attributable to epilepsy, Journal of Neurology, Neurosurgery and Psychiatry, 73, (6), 2002, p751 - 752
Langan Y, Sander JWAS, Sudden unexpected death in epilepsy, CNS Drugs, 13, (5), 2000, p337 - 349
Langan Y, Nashef L, Sander JWAS, Sudden unexpected death in epilepsy: a series of witnessed deaths., Journal of Neurology, Neurosurgery and Psychiatry, 68, (2), 2000, p211 - 213
Langan, Y., Sander, J.W.A.S., Sudden unexpected death in patients with epilepsy: Definition, epidemiology and therapeutic implications, CNS Drugs, 13, (5), 2000, p337-349
Langan Y, Sudden unexpected death in epilepsy(SUDEP): risk factors and case control studies, Seizure, 9, (3), 2000, p179 - 183
Langan Y, Duncan JS, Sander JW., An audit of the perdeived efficacy and tolerability of gabapentin therapy in an outpatient cohort with chronic epilepsy, European Neurology, 41, (2), 1999, p111 - 113
Langan Y, Sander JWAS, Patients with epilepsy who die do not always have cardiac disease, Archives of Neurology, 56, (2), 1999, p249 - 249
Langan Y, Nashef L, Sander JWAS, The certification of deaths due to epilepsy, Association of British Neurologists, London, April 1999, 1999
Lhatoo SD, Langan Y, Sander JWAS, Sudden unexpected death in epilepsy, Postgraduate Medical Journal, 75, (890), 1999, p706 - 709
Hennessy MJ, Langan Y, Elwes RDC, Binnie CD, Polkey CE, Nashef L., A study of mortality after temporal lobe epilepsy surgery, Neurology, 53, (6), 1999, p1276 - 1283
Langan Y, Nashef L., Sudden unexpected death in epilepsy, Neurology Reviews International, 3, 1999, p5 - 8
Lhatoo SD, Langan Y, MacDonald BK, Zeidan S, Sander JW, Sudden unexpected death: a rare event in a large comminity based prospective cohort with newly diagnosed epilepsy and high remission rates., Journal of Neurology, Neurosurgery and Psychiatry, 66, (5), 1999, p692 - 693
Lhatoo SD, Langan Y, Sander JWAS, Sudden death in epilepsy- an overview, Brazilian Journal of Epilepsy and Clinical Neurophysiology, 4, 1998, p167 - 170
Langan Y, Nolan M, Hutchinson M., The incidence of sudden unexpected death in South Dublin and Wicklow, Seizure, 7, (5), 1998, p355 - 358
Gavin C, Langan Y, Hutchinson M., Cranial and peripheral neuropathy after EBV infection., Postgraduate Medical Journal, 73, (861), 1997, p419 - 420
, Cranial and peripheral neuropathy due to Epstein-Barr virus infection., Postgraduate medical journal, 1997
Non-Peer-Reviewed Publications
Langan Y, SUDEP and Alcohol, Royal Society of Medicine Epilepsy session, RSM, London, 26/01/21, 2021, B McDonald
Research Expertise
Description
I have a particular interest in epilepsy mortality and sudden unexpected death in epilepsy (SUDEP) has been a major focus of my research. I was responsible for the design, conduct and analysis of a case control study examining risk factors for SUDEP, the largest such study to date which has established me as an expert in the field. I was awarded the Hastings Fellowship in support of this work which was also supported by the UK charity Epilepsy Bereaved. This work made a significant contribution to the body of knowledge on the subject and has informed guidelines such as those produced by NICE. This work led to international collaboration with with other experts as part of the work of the International League against Epilepsy(ILAE) commission on epidemiology. I have supported and supervised a Research Fellow in the Department of Clinical Neurophysiology to investigate the role of baroreceptor sensitivity in the genesis of SUDEP, work which was successfully awarded MD and which was supporting by funding from Epilepsy Ireland. This work was awarded the Kirker prize in epilepsy at the Irish Neurological Association meeting in 2013. I have undertaken a study on epilepsy mortality in Ireland in collaboration with the Health Research Board(HRB)and the Irish coroners. We have examined coronial records from 2019 in order to identify and categorise deaths in those with epilepsy with a particular focus on epilepsy related deaths. This work is supported by a grant from the Irish Institute of Clinical Neuroscience and Epilepsy Ireland. This work has resulted in a publication of the incidence of SUDEP in Ireland with work ongoing on other epilepsy related deaths. Presently I am on the steering committee of an International multicentre case control study in SUDEP coordinated by Prof. Peter Bergin in New Zealand and am awaiting ethics approval to identify Irish cases. I am examining EEG changes in those undergoing CAR-T therapy. Further work on this topic will be undertaken with Dr Roisin McMackin of the McMackin Institute. I am one of a number of principal investigators from a number of schools who have been awarded a TRDA undertaking research into disorders of brain development across the lifespan.Projects
- Title
- Disorders of brain development across the slifespan: insights from rare genetic conditions
- Funding Agency
- TRDA
- Date From
- 01/09/2025
- Date To
- 01/09/2030
- Title
- The incidence of sudden unexpected death in epilepsy (SUDEP) in Ireland
- Summary
- This work was undertaken in collaboration with the Health Research Board and coronial records form 2019 were examined to allow the identification of SUDEP cases and the subsequent calculation of an incidence rate for Ireland.
- Funding Agency
- Epilepsy Ireland, Irish Institute of Clinical Neuroscience
- Date From
- 2019
- Date To
- 2025
- Title
- Epilepsy related deaths in Ireland
- Summary
- In collaboration with the HRB coronial records for 2019 have been examined in an effort to identify non SUDEP epilepsy related deaths.
- Funding Agency
- Epilepsy Ireland, Irish Institute of Clinical Neuroscience
- Date From
- 2020
- Title
- EEG in CAR-T patients
- Summary
- To examine whether EEG changes in patients being treated with CAR-T are predictive of ICANS
- Funding Agency
- Consultant Innovation fund
- Title
- Case control study of SUDEP
- Summary
- International SUDEP case control study
- Title
- Baroreceptor sensitivity in epilepsy
- Summary
- examine whether baroreceptor sensitivity is altered on those with epilepsy and whether this is important in SUDEP
- Funding Agency
- Epilepsy Ireland
- Title
- Case control study of SUDEP
- Summary
- UK wide case control study of SUDEP to identify risk factors
- Funding Agency
- Hastings fellowhip
- Title
- ultra long EEG
- Funding Agency
- Innovation funding
Recognition
Memberships
Fellowhip Royal College of Physicians of Ireland
Royal College of Physicians of Ireland
The Irish Institute of Clinical Neuroscience
International League against Epilepsy
Irish Society of Clinical Neurophysiology