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Mani Ramaswami
Professor of Neurogenetics, Genetics
Director of TCIN, Trinity Inst. of Neurosciences (TCIN)
Director of TCIN, Zoology

Publications and Further Research Outputs

Peer-Reviewed Publications

Bakthavachalu, B. and Huelsmeier, J. and Sudhakaran, I.P. and Hillebrand, J. and Singh, A. and Petrauskas, A. and Thiagarajan, D. and Sankaranarayanan, M. and Mizoue, L. and Anderson, E.N. and Pandey, U.B. and Ross, E. and VijayRaghavan, K. and Parker, R. and Ramaswami, M., RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration, Neuron, 98, (4), 2018, p754-766.e4 Journal Article, 2018 DOI

Kuklin, E.A. and Alkins, S. and Bakthavachalu, B. and Genco, M.C. and Sudhakaran, I. and Raghavan, K.V. and Ramaswami, M. and Griffith, L.C., The long 3′UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster, Journal of Neuroscience, 37, (44), 2017, p10544-10566 Journal Article, 2017 DOI

Sudhakaran I.P, Ramaswami M, Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains, RNA Biology , 14, (5), 2017, p568-586 Journal Article, 2017 DOI URL

Barron, H.C., Vogels, T.P., Behrens, T.E., Ramaswami, M. , Inhibitory engrams in perception and memory , Proceedings of the National Academy of Sciences of the United States of America, 114, (6), 2017, p6666-6674 Journal Article, 2017 DOI

Choudhury S.D, Mushtaq Z, Reddy-Alla S, Balakrishnan S.S, Thakur R.S, Krishnan K.S, Raghu P, Ramaswami M, Kumar V, Ï 2-Adaptin facilitates basal synaptic transmission and is required for regenerating endo-exo cycling pool under high-frequency nerve stimulation in drosophila, Genetics, 203, (1), 2016, p369 - 385 Journal Article, 2016 URL DOI

Sarov M, Barz C, Jambor H, Hein M.Y, Schmied C, Suchold D, Stender B, Janosch S, Vinay Vikas K.J, Krishnan R.T, Krishnamoorthy A, Ferreira I.R.S, Ejsmont R.K, Finkl K, Hasse S, KÃ"mpfer P, Plewka N, Vinis E, Schloissnig S, Knust E, Hartenstein V, Mann M, Ramaswami M, VijayRaghavan K, Tomancak P, Schnorrer F, A genome-wide resource for the analysis of protein localisation in Drosophila, eLife, 5, (FEBRUARY), 2016, pe12068- Journal Article, 2016 TARA - Full Text DOI URL

Carreira-Rosario A, Bhargava V, Hillebrand J, Kollipara R.K, Ramaswami M, Buszczak M, Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation, Developmental Cell, 36, (5), 2016, p562 - 571 Journal Article, 2016 DOI URL

Kacsoh B.Z, Bozler J, Hodge S, Ramaswami M, Bosco G, A novel paradigm for nonassociative long-term memory in Drosophila: Predator-induced changes in oviposition behavior, Genetics, 199, (4), 2015, p1143 - 1157 Journal Article, 2015 DOI URL

Mullin, A.P., Sadanandappa, M.K., Ma, W., (...), Sanyal, S., Faundez, V. , Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity, Journal of Neuroscience, 35, (1), 2015, p325-338 Journal Article, 2015 TARA - Full Text DOI

Kacsoh B.Z, Bozler J, Ramaswami M, Bosco G, Social communication of predator-induced changes in Drosophila behavior and germline physiology, eLife, 4, (MAY), 2015, p07423- Journal Article, 2015 URL TARA - Full Text DOI

Sudhakaran, IP, Hillebrand, J, Dervan, A, Das, S, Holohan, EE, Hulsmeier, J, Sarov, M, Parker, R, VijayRaghavan, K, Ramaswami, M, FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, (1), 2014, pE99-E108 Journal Article, 2014 DOI

Ramaswami, M., Network plasticity in adaptive filtering and behavioral habituation, Neuron, 82, (6), 2014, p1216-1229 Journal Article, 2014 TARA - Full Text DOI

Twick, I. , Lee, J.A. , Ramaswami, M, Olfactory habituation in drosophila-odor encoding and its plasticity in the antennal lobe , Progress in Brain Research, 208, 2014, 3-38 Journal Article, 2014 DOI

Sadanandappa, MK, Redondo, BB, Michels, B, Rodrigues, V, Gerber, B, VijayRaghavan, K, Buchner, E, Ramaswami, M, Synapsin Function in GABA-ergic Interneurons Is Required for Short-Term Olfactory Habituation, JOURNAL OF NEUROSCIENCE, 33, (42), 2013, p16576-16585 Journal Article, 2013 TARA - Full Text DOI

Ramaswami, M. , Taylor, J.P. , Parker, R, Altered ribostasis: RNA-protein granules in degenerative disorders, Cell, 154, (4), 2013, p727-736 Journal Article, 2013 TARA - Full Text DOI

Sadandappa, MK, Ramaswami, M, Fly model causes neurological rethink, ELIFE, 2, 2013, pe01820- Journal Article, 2013 DOI TARA - Full Text

Redondo, BB, Bunz, M, Halder, P, Sadanandappa, MK, Muhlbauer, B, Erwin, F, Hofbauer, A, Rodrigues, V, VijayRaghavan, K, Ramaswami, M, Rieger, D, Wegener, C, Forster, C, Buchner, E, Identification and Structural Characterization of Interneurons of the Drosophila Brain by Monoclonal Antibodies of the Wurzburg Hybridoma Library, PLOS ONE, 8, (9), 2013, pe75420.- Journal Article, 2013 TARA - Full Text DOI

Kangyu Pan, David Corrigan, Jens Hillebrand, Mani Ramaswami, and Anil Kokaram, A wavelet-based Bayesian framework for 3D object segmentation in microscopy, Proceedings of SPIE, 8227, 2012, part. no. 82271O Journal Article, 2012 TARA - Full Text

Krishnan, K.S., Ramaswami, M., Wu, C.-F..., Obaid Siddiqi at 80 and neurogenetics in India, Journal of Neurogenetics, 26, (3-4), 2012, p255-256 Journal Article, 2012 DOI

Tabone, C.J., Ramaswami, M., Is NMDA Receptor-Coincidence Detection Required for Learning and Memory?, Neuron, 74, (5), 2012, 767-769 Journal Article, 2012 DOI

Sudhakaran, I.P., Holohan, E.E., Osman, S., Rodrigues, V., Vijay Raghavan, K., Ramaswami, M., Plasticity of recurrent inhibition in the Drosophila antennal lobe, Journal of Neuroscience , 32, (21), 2012, p7225-7231 Journal Article, 2012 TARA - Full Text DOI

Pradhan, S.J., Nesler, K.R., Rosen, S.F., Kato, Y., Nakamura, A., Ramaswami, M., Barbee, S.A., The conserved p body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction, Journal of Cell Science, 125, (24), 2012, p6105-6116 Journal Article, 2012 DOI

Paranjpe, P., Rodrigues, V., Raghavan, K.V., Ramaswami, M.., Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons, Learning and Memory, 19, (12), 2012, p627-635 Journal Article, 2012 DOI

McCann, C., Holohan, E.E., Das, S., Dervan, A., Larkin, A., Lee, J.A., Rodrigues, V., (...), Ramaswami, M., The ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation, Proceedings of the National Academy of Sciences of the United States of America , 108, (36), 2011, pE655-E662 Journal Article, 2011

Phillips, A.M., Ramaswami, M., Kelly, L.E., Stoned , Traffic, 11, (1), 2010, p16-24 Journal Article, 2010

Hillebrand J, Pan K, Kokaram A, Barbee S, Parker R, Ramaswami M, The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons., Frontiers in Neural Circuits, 4, 2010, p121 Journal Article, 2010 DOI TARA - Full Text

Larkin, A., Karak, S., Priya, R., Das, A., Ayyub, C., Ito, K., Rodrigues, V., Ramaswami, M., Central synaptic mechanisms underlie short-term olfactory habituation in Drosophila larvae, Learning and Memory, 17, (12), 2010, p645-653 Journal Article, 2010

Amanda Freeman, Mallory Bowers, Alysia Vrailas Mortimer, Christina Timmerman, Stephanie Roux, Mani Ramaswami and Subhabrata Sanyal, A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila , Brain Research, 1326 , 2010, p15-29 Journal Article, 2010 TARA - Full Text

Pan, K., Kokaram, A., Hillebrand, J., Ramaswami, M., Gaussian mixture models for spots in microscopy using a new split/merge EM algorithm, Proceedings - International Conference on Image Processing, ICIP, 17th IEEE International Conference on Image Processing, ICIP 2010; , Hong Kong, 26-29 Sept, 2010, 3645-3648 Conference Paper, 2010

Pan, K., Kokaram, A., Hillebrand, J., Ramaswami, M.., Gaussian mixtures for intensity modeling of spots in microscopy, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings , 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings , Rotterdam; Netherland, 14-17 Apr, 2010, pp121-124 Conference Paper, 2010

Cziko, AM, McCann, CT, Howlett, IC, Barbee, SA, Duncan, RP, Luedemann, R, Zarnescu, D, Zinsmaier, KE, Parker, RR, Ramaswami, M, Genetic Modifiers of DFMR1 Encode RNA-Granule Components in Drosophila., Genetics, 2009 Journal Article, 2009 DOI

Kim, SM, Kumar, V, Lin, YQ, Karunanithi, S, Ramaswami, M, Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse., Proceedings of the National Academy of Sciences of the United States of America, 106, (10), 2009, p4000-4005 Journal Article, 2009 DOI

Chiang, A, Priya, R, Ramaswami, M, Vijayraghavan, K, Rodrigues, V, Neuronal activity and Wnt signaling act through Gsk3-beta to regulate axonal integrity in mature Drosophila olfactory sensory neurons., Development (Cambridge, England), 136, (8), 2009, p1273-1282 Journal Article, 2009 DOI

Kumar, V, Alla, SR, Krishnan, KS, Ramaswami, M, Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction., Molecular and cellular neurosciences, 40, (2), 2009, p234-241 Journal Article, 2009 DOI

Kumar, V, Fricke, R, Bhar, D, Reddy-Alla, S, Krishnan, KS, Bogdan, S, Ramaswami, M, Syndapin promotes formation of a postsynaptic membrane system in Drosophila., Molecular biology of the cell, 20, (8), 2009, p2254-2264 Journal Article, 2009 DOI URL

Ramaswami, M, Indian Biological Sciences: Aiming Even Higher, Current Science, 96, (5), 2009, p639 - 640 Journal Article, 2009

Das, S., Larkin, A., Karak, S., Dervan, A., Madhumala, K.S., Pimentel, A., Gandhi, A., Ito, K., Wang, J., Sanyal, S., Rodrigues, V. and Ramaswami, M. , Potentiation of GABAergic interneurons is necessary for short- and long-term forms of olfactory habituation., 2009 Journal Article, 2009

Pollock, JD, Ramaswami, M, The Genetics and Epigenetics of Addiction., Journal of Neurogenetics, 2009 Journal Article, 2009 URL DOI

Hartwig, CL, Worrell, J, Levine, RB, Ramaswami, M, Sanyal, S, Normal dendrite growth in Drosophila motor neurons requires the AP-1 transcription factor., Developmental neurobiology, 68, (10), 2008, p1225-1242 Journal Article, 2008 DOI

Beckham, C, Hilliker, A, Cziko, AM, Noueiry, A, Ramaswami, M, Parker, R, The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies., Molecular biology of the cell, 19, (3), 2008, p984-993 Journal Article, 2008 DOI

Wu, CF, Ramaswami, M, The origins of neurogenetics., Journal of Neurogenetics, 21, (4), 2008, p165 - 167 Journal Article, 2008 DOI

Kwak, JE, Drier, E, Barbee, SA, Ramaswami, M, Yin, JC, Wickens, M, GLD2 poly(A) polymerase is required for long-term memory., Proceedings of the National Academy of Sciences of the United States of America, 105, (38), 2008, p14644-14649 Journal Article, 2008 DOI

Hillebrand, J., Barbee, S.A., Ramaswami, M. , P-body components, microRNA regulation, and synaptic plasticity , TheScientificWorldJournal , 7, (SUPPL. 2), 2007, p178-190 Journal Article, 2007 DOI

Kumar, V, Ramaswami, M, Kissing and pinching: synaptotagmin and calcium do more between bilayers., Neuron, 50, (1), 2006, p3-5 Journal Article, 2006 DOI

Barbee, SA, Estes, PS, Cziko, AM, Hillebrand, J, Luedeman, RA, Coller, JM, Johnson, N, Howlett, IC, Geng, C, Ueda, R, Brand, AH, Newbury, SF, Wilhelm, JE, Levine, RB, Nakamura, A, Parker, R, Ramaswami, M, Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies., Neuron, 52, (6), 2006, p997-1009 Journal Article, 2006 DOI

Activity-dependent regulation of transcription during development of synapses in, editor(s)Ed. Budnik. , Neuromuscular Junctions of Drosophila (II), 2006, [Sanyal, S. and Ramaswami, M.] Book Chapter, 2006

Sanyal S, Jennings T, Dowse H, Ramaswami M, Conditional mutations in SERCA, the sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology , 176, (3), 2006, p253 - 263 Journal Article, 2006 DOI

Sanyal, S, Ramaswami, M, Activity-dependent regulation of transcription during development of synapses., International Review of Neurobiology, 75, 2006, p287-305 Journal Article, 2006 DOI

Narayanan, R, Leonard, M, Song, BD, Schmid, SL, Ramaswami, M, An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function., The Journal of Cell Biology, 169, (1), 2005, p117-126 Journal Article, 2005 DOI

Etter, PD, Narayanan, R, Navratilova, Z, Patel, C, Bohmann, D, Jasper, H, Ramaswami, M, Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons., BMC Neuroscience, 6, 2005, p39 Journal Article, 2005 DOI

Gowd, KH, Sabareesh, V, Sudarslal, S, Iengar, P, Franklin, B, Fernando, A, Dewan, K, Ramaswami, M, Sarma, SP, Sikdar, S, Balaram, P, Krishnan, KS, Novel peptides of therapeutic promise from Indian Conidae., Annals of the New York Academy of Sciences, 1056, 2005, p462-473 Journal Article, 2005 DOI

Sanyal S, Consoulas C, Kuromi H, Basole A, Mukai L, Kidokoro Y, Krishnan KS, Ramaswami M, Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability, Genetics, 169, (2), 2005, p737 - 750 Journal Article, 2005 DOI

Sanyal S, Kim SM, Ramaswami M, Retrograde regulation in the CNS: Neuron-specific interpretations of TGF-beta signaling, Neuron, 41, (6), 2004, p845 - 848 Journal Article, 2004 DOI

Menon KP, Sanyal S, Habara Y, Sanchez R, Wharton RP, Ramaswami M, Zinn K, The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor elF-4E, Neuron, 44, (4), 2004, p663 - 676 Journal Article, 2004 DOI

Sudarslal S, Majumdar S, Ramasamy P, Dhawan R, Pal PP, Ramaswami M, Lala AK, Sikdar SK, Sarma SP, Krishnan KS, Balaram P, Sodium channel modulating activity in a 5-conotoxin from an Indian marine snail, FEBS Letters, 553, (1-2), 2003, p209 - 212 Journal Article, 2003 DOI

Narayanan, R, Ramaswami, M, Regulation of dynamin by nucleoside diphosphate kinase., Journal of Bioenergetics and Biomembranes, 35, (1), 2003, p49-55 Journal Article, 2003 DOI

Hoeffer, CA, Sanyal, S, Ramaswami, M, Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 23, (15), 2003, p6362-6372 Journal Article, 2003 URL

Jackson T, Ramaswami M, Prospects of memory-modifying drugs that target the CREB pathway, Current Opinion in Drug Discovery and Development , 6, (5), 2003, p712-719 Review, 2003 URL

Ramaswami M, Specifying the age-sensitive component of a short-term memory, Neuron, 40, (5), 2003, p877 - 879 Journal Article, 2003 DOI

Estes PS, Jackson TC, Stiimson DT, Sanyal S, Kelly LE, Ramaswami M, Functional dissection of a eukaryotic dicistronic gene: Transgenic stonedB, but not stonedA, restores normal synaptic properties to Drosophila stoned mutants, Genetics, 165, (1), 2003, p185 - 196 Journal Article, 2003 URL

Rikhy R, Ramaswami M, Krishnan KS, A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation, Genetics, 165, (3), 2003, p1243 - 1253 Journal Article, 2003 URL

Sanyal S, Narayanan R, Consoulas C, Ramaswami M, Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity, BMC Neuroscience, 4, (20), 2003 Journal Article, 2003 DOI

Devaud, JM, Acebes, A, Ramaswami, M, Ferrús, A, Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age., Journal of Neurobiology, 56, (1), 2003, p13-23 Journal Article, 2003 DOI

Therapeutic Uses of Embryonic Stem Cells in, editor(s)A Chiu and M. Rao. , Human Embryonic Stem Cells., NJ, Humana Press,, 2003, pp297-332 , [Kamb A. Ramaswami M. , and Rao M.S ] Book Chapter, 2003

Sanyal, S, Sandstrom, DJ, Hoeffer, CA, Ramaswami, M, AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila., Nature, 416, (6883), 2002, p870-874 Journal Article, 2002 DOI

Etter, PD, Ramaswami, M, The ups and downs of daily life: profiling circadian gene expression in Drosophila., BioEssays : news and reviews in molecular, cellular and developmental biology, 24, (6), 2002, p494-498 Journal Article, 2002 DOI

Sanyal, S, Ramaswami, M, Spinsters, synaptic defects, and amaurotic idiocy., Neuron, 36, (3), 2002, p335-338 Journal Article, 2002 DOI

Kamb, A, Ramaswami, M, A simple method for statistical analysis of intensity differences in microarray-derived gene expression data., BMC Biotechnology, 1, 2001 Journal Article, 2001 DOI

Krishnan, KS, Rikhy, R, Rao, S, Shivalkar, M, Mosko, M, Narayanan, R, Etter, P, Estes, PS, Ramaswami, M, Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling., Neuron, 30, (1), 2001, p197-210 Journal Article, 2001 DOI

Stimson, DT, Estes, PS, Rao, S, Krishnan, KS, Kelly, LE, Ramaswami, M, Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 21, (9), 2001, p3034-3044 Journal Article, 2001 URL

Narayanan, R, Ramaswami, M, Endocytosis in Drosophila: progress, possibilities, prognostications., Experimental Cell Research, 271, (1), 2001, p28-35 Journal Article, 2001 DOI

DeZazzo, J, Sandstrom, D, de Belle, S, Velinzon, K, Smith, P, Grady, L, DelVecchio, M, Ramaswami, M, Tully, T, nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory., Neuron, 27, (1), 2000, p145-158 Journal Article, 2000 DOI

Phillips, A.M., Smith, M., Ramaswami, M. and Kelly, L.E., Interactions between the products of the Drosophila stoned locus and the vesicle-membrane protein, synaptotagmin., Journal of Neuroscience, 20, 2000, p8254-8261 Journal Article, 2000 URL

Estes, PS, Ho, GL, Narayanan, R, Ramaswami, M, Synaptic localization and restricted diffusion of a Drosophila neuronal synaptobrevin--green fluorescent protein chimera in vivo., Journal of Neurogenetics, 13, (4), 2000, 233-255 Journal Article, 2000 DOI

Phillips, AM, Smith, M, Ramaswami, M, Kelly, LE, The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 20, (22), 2000, p8254-8261 Journal Article, 2000 URL

Narayanan, R., Kramer, H . and Ramaswami, M, Drosophila endosomal proteins Hook and Deep orange regulate synapse size but not synaptic vesicle recycling., Journal of Neurobiology, 45, (2), 2000, p105-119 Journal Article, 2000 DOI

Sohrabji, F, Peeples, KW, Marroquin, OA, Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen., Journal of Neurobiology, 45, (2), 2000, p61-74 Journal Article, 2000 DOI

Vesicle recycling at the Drosophila Neuromuscular junction. in, editor(s)Budnik, V. and Gramates, G. , Neuromuscular Junctions of Drosophila., (USA) , International Reviews of Neurobiology Series. ACADEMIC PRESS , 1999, pp163-189. , [Stimson, D. and Ramaswami, M. ] Book Chapter, 1999

Ito, K, Suzuki, K, Estes, P, Ramaswami, M, Yamamoto, D, Strausfeld, NJ, The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen., Learning & memory (Cold Spring Harbor, N.Y.), 5, (1-2), 1999 Journal Article, 1999

Endocytosis at the nerve terminal. in, editor(s)Ed. H. Bellen. , Neurotransmitter Release., Oxford University Press. , 1999, pp389-431 , [Zhang, B. and Ramaswami, M. ] Book Chapter, 1999

Staples, RR, Ramaswami, M, Functional analysis of dynamin isoforms in Drosophila melanogaster., Journal of neurogenetics, 13, (3), 1999, p119-143 Journal Article, 1999 DOI

Stimson, DT, Ramaswami, M, Vesicle recycling at the Drosophila neuromuscular junction., International review of neurobiology, 43, 1999, p163-187 Journal Article, 1999

Grant, D, Unadkat, S, Katzen, A, Krishnan, KS, Ramaswami, M, Probable mechanisms underlying interallelic complementation and temperature-sensitivity of mutations at the shibire locus of Drosophila melanogaster., Genetics, 149, (2), 1998, p1019-1030 Journal Article, 1998 URL

Ito, K., Suzuki, K., Estes, P.E., Ramaswami, M., Yamamoto, D. and Strausfeld, N. , The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster meigen , Learning and Memory, 5, (1-2), 1998, p52-77 Journal Article, 1998 URL

Ramaswami, M. , How "carrots and sticks" are encoded in the brain: motivation, reward, addiction and fear., Journal of Bioscience, 23, (3), 1998, p163-164. Journal Article, 1998 DOI

Stimson, DT, Estes, PS, Smith, M, Kelly, LE, Ramaswami, M, A product of the Drosophila stoned locus regulates neurotransmitter release., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 18, (23), 1998, p9638-9649 Journal Article, 1998 URL

Lloyd, V, Ramaswami, M, Krämer, H, Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery., Trends in cell biology, 8, (7), 1998, p257-259 Journal Article, 1998 DOI

Mir, B, Iyer, S, Ramaswami, M, Krishnan, KS, A genetic and mosaic analysis of a locus involved in the anesthesia response of Drosophila melanogaster., Genetics, 147, (2), 1997, p701-712 Journal Article, 1997 URL

Krishnan, KS, Chakravarty, S, Rao, S, Raghuram, V, Ramaswami, M, Alleviation of the temperature-sensitive paralytic phenotype of shibire(ts) mutants in Drosophila by sub-anesthetic concentrations of carbon dioxide., Journal of Neurogenetics, 10, (4), 1996, p221-228 Journal Article, 1996 DOI

Estes, PS, Roos, J, van der Bliek, A, Kelly, RB, Krishnan, KS, Ramaswami, M, Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 16, (17), 1996, p5443-5456 Journal Article, 1996 URL

Endocytotic pathways in neurons. in, editor(s)K.S. Kosick et al. , Alzheimer's Disease: Lessons from Cell Biology, Research and Perspectives in Alzheimer's Disease, Berlin Heidelberg, Springer Verlag , 1995, pp1-13. , [Grote, E., Bonzelius, F., Herman, G., Ramaswami, M., van de Goor, J., Green, S. and Kelly, R.B] Book Chapter, 1995

Van de Goor, J., Ramaswami, M. and Kelly, R.B., Redistribution of synaptic vesicles and their proteins in shibirets1 mutant Drosophila., Proceedings of the National Academy of Sciences of the United States of America, 92, (12), 1995, p5739-5743 Journal Article, 1995 URL

Pallanck, L, Ordway, RW, Ramaswami, M, Chi, WY, Krishnan, KS, Ganetzky, B, Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog., The Journal of Biological Chemistry, 270, (32), 1995, p18742-18744 Journal Article, 1995 DOI

Ramaswami, M, Krishnan, KS, Kelly, RB, Intermediates in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions., Neuron, 13, (2), 1994, p363-375 Journal Article, 1994 DOI

Ramaswami, M., Krishnan, K.S. and Kelly, R.B, Intermediate stages in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions, Neuron, 13, 1994, p363-375 Journal Article, 1994

Ramaswami, M, Tanouy, M, Mathew, MK, Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs., Indian Journal of Biochemistry & Biophysics, 31, (4), 1994, p254-260 Journal Article, 1994

Ramaswami, M, Tanouye, M.A and Mathew, M.K , Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs., Indian Journal of Biochemistry & Biophysics, 31, (4), 1994, p254-260 Journal Article, 1994

Pavlidis, P, Ramaswami, M, Tanouye, MA, The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis., Cell, 79, (1), 1994, p23-33 Journal Article, 1994 DOI

Ramaswami, M, Rao, S, van der Bliek, A, Kelly, RB, Krishnan, KS, Genetic studies on dynamin function in Drosophila., Journal of Neurogenetics, 9, (2), 1993, p73-87 Journal Article, 1993 DOI

Ramaswami, M., Rabid roles in vesicle fusion., Current Science, 64, (4), 1993, p214 Journal Article, 1993 URL

Ramaswami, M., Voltage-Gated Channels: Perspectives and Progress., Current Science, 62, 1992, p341-354 Journal Article, 1992

Ramaswami, M., The Nobel Prize in Physiology and Medicine. , 1991, - 20. Miscellaneous, 1991

McCormack, K.J., Iverson, L., Lin, J.W., Ramaswami, M., Mathew, M.K., McCormack, T.J., Rudy, B., and Tanouye, M.A., Mutagenesis of a leucine heptad repeat involved in voltage-dependent gating of Shaker potassium channels., Proceedings of the National Academy of Sciences of the United States of America, 88, 1991, p2931-2935. Journal Article, 1991

Ramaswami, M., Gautam, M., Kamb, C.A., Rudy, B., Tanouye, M.A. and Mathew, M.K. , Human potassium channel genes: molecular cloning and functional expression. , Molecular Cell Neuroscience, 1, (3), 1990, p214-223. Journal Article, 1990 DOI

Ramaswami, M. , Molecular genetic studies on voltage-gated ion channels., 1990, - Miscellaneous, 1990

Drosophila homologs of vertebrate sodium channel genes. in, editor(s)R.N.Singh and N. J. Strausfeld , The Neurobiology of Sensory Systems., NY, Plenum , 1989, pp449-467. , [Ramaswami, M., Lashgari, A. and Tanouye, M.A. ] Book Chapter, 1989

McCormack, K.J., Campanelli, J.T., Ramaswami, M., Mathew, M.K., Tanouye, M.A., Iverson, L.E. and Rudy, B., Leucine-zipper motif update., Nature, 340, 1989, p103-104 Journal Article, 1989 DOI

Ramaswami, M, Tanouye, MA, Two sodium-channel genes in Drosophila: implications for channel diversity., Proceedings of the National Academy of Sciences of the United States of America, 86, (6), 1989, p2079-2082 Journal Article, 1989 URL

Research Expertise

Description

Research interests 
 My laboratory is interested in understanding molecular and circuit mechanisms of simple learned behaviors. We use the genetic model organism Drosophila melanogaster to study fundamental synaptic mechanisms as well as mechanisms of simple olfactory memory. An obvious extension of these studies to ask how these mechanisms are affected in disease and we currently study disease models for fragile-X mental retardation and spinocerebellar ataxia. Five post-doctoral researchers and three postgraduate students in my lab use many in vivo approaches including Drosophila genetics, two-photon microscopy based live-brain imaging, electrophysiology, and a range of cell biological, behavioral & molecular techniques. Several collaborations, particularly with top research groups in India and the US, expand our work into other fields such as natural products and peptide neurotoxins. Recent advances in the lab include the following. 1. Primarily in collaboration with Veronica Rodrigues' group in the NCBS, Bangalore, we have discovered that gene expression- and synaptic growth dependent potentiation of GABAergic neurons drives specific forms of learned olfactory behavior. 2. In collaboration with Roy Parker at the University of Arizona, we have found that that proteins and mechanisms that control translation of mRNAs in yeast, also regulate the translation of mRNAs stored in synapses. Some of these regulatory mechanisms, required for proper neuronal homeostasis/plasticity are required for miRNA function and altered in human neurological disease.

Projects

  • Title
    • Science Foundation of Ireland Investigator
  • Summary
  • Date From
    • 2007
  • Date To
    • 2011
  • Title
    • Wellcome Trust Cellular and genetic analysis of synapse assembly and function (Project Grant)
  • Summary
    • Role PI
  • Funding Agency
    • Wellcome Trust
  • Date From
    • 2006
  • Date To
    • 2008
  • Title
    • Dept of Biotechnology, Govt of India. Circuit mechanisms of long-term habituation
  • Summary
    • Role: Collaborator (PI: Veronica Rodrigues)
  • Title
    • Deep sequencing of venom duct cDNAs from Indian cone snails
  • Summary
    • Dept of Biotechnology, Govt of India. Role: Collaborator (PI: K.S. Krishnan)
  • Title
    • Science Foundation of Ireland Research Professor.
  • Summary
  • Date From
    • 2005
  • Date To
    • 2007
  • Title
    • Fos, Jun and the transcriptional control of synaptic plasticity.
  • Summary
  • Funding Agency
    • NIH/NIDA (RO1):
  • Date From
    • March '03
  • Date To
    • Feb '08
  • Title
    • Fos, Jun and the transcriptional control of synaptic plasticity
  • Summary
    • (Career Development Award).
  • Funding Agency
    • NIDA (K02)
  • Date From
    • Sept 2004
  • Date To
    • August 2010.
  • Title
    • Molecular mechanisms of synaptic-vesicle recycling.
  • Summary
  • Funding Agency
    • NIH/NINDS (RO1)
  • Date From
    • April '01
  • Date To
    • Mar.'05
  • Title
    • Identification of Drosophila proteins modified by neural activity: a proteomic and genetic approach.
  • Funding Agency
    • NIH/NIDA (R21)
  • Date From
    • April '02
  • Date To
    • Mar '04
  • Title
    • Analysis of the pathway of SPIRE, an actin-binding protein.
  • Summary
    • March of Dimes
  • Date From
    • March'03
  • Date To
    • May '04
  • Title
    • A novel technology for protein delivery to the CNS.
  • Summary
    • (Small Business Innovation Research Grant to Q. Therapeutics)
  • Funding Agency
    • NIH/NINDS (R43)
  • Title
    • Molecular mechanisms of synaptic-vesicle recycling
  • Summary
  • Funding Agency
    • NIH/NINDS (RO1)
  • Date From
    • Mar. 1997
  • Date To
    • Feb. 2001
  • Title
    • Novel technologies for identification and analysis of genes involved in long-term neural plasticity.
  • Summary
  • Funding Agency
    • NIH/ NIDA (RO1)
  • Date From
    • Oct. 1999
  • Date To
    • Sept. 2002
  • Title
    • Molecular Mechanisms of synaptic vesicle recycling
  • Summary
    • (Career Development Award)
  • Funding Agency
    • NIH/ NIMH (K02)
  • Date From
    • Sept.1997
  • Date To
    • Aug. 2002
  • Title
    • Dissection of molecular and cellular mechanisms underlying neural plasticity in the fruit fly and the honey bee..
  • Funding Agency
    • HFSPO
  • Date From
    • 1999
  • Date To
    • 2003
  • Title
    • McKnight Award
  • Summary
    • Genetic analysis of presynaptic mechanisms.
  • Date From
    • 1995
  • Date To
    • 1997
  • Title
    • Sloan Award
  • Summary
    • Genetic analysis of presynaptic mechanisms.
  • Date From
    • 1995
  • Date To
    • 1998.
  • Title
    • In vivo analysis of dynamin function in synaptic vesicle recycling.
  • Summary
  • Funding Agency
    • NSF
  • Date From
    • 1995
  • Date To
    • 1998.
  • Title
    • A genetic and cellular analysis of synaptic function in Drosophila.
  • Funding Agency
    • HFSPO
  • Date From
    • 1995
  • Date To
    • 1998

Recognition

Awards and Honours

Professorial Fellowship, Trinity College Dublin. 2009

Galileo Circle Fellow, College of Science, University of Arizona. 2005

NIDA K (Career Development/ Research Leave) Award. (declined in 2008) 2004-2010

Cutting Edge Brain Research Award (CEBRA) from the NIDA. 2002

Early Tenure, University of Arizona 2000

HFSPO Research Grant Award 1999

NIH Research Career Development Award 1997-2002

McKnight Scholar's Award in Neuroscience 1995

Alfred P. Sloan Fellowship in Neuroscience 1995

HFSPO Research Grant Award 1995

Life Science Research Foundation Fellowship 1994

HFSPO Long-Term Fellowship 1992 -1993

Associate of the Indian Academy of Sciences 1991

Proctor and Gamble Research Fellowship 1990

Markey Charitable Trust Fellowship 1985-1988

Evelyn Sharp Graduate Fellowship 1985-1988

The Institute Silver Medal (for the best student of Chemistry) Indian Institute of Technology, New Delhi 1984

Arthur McCallum Graduate Fellowship 1984