Mani Ramaswami
, Genetics
, Trinity Inst. of Neurosciences (TCIN)
, Zoology
Publications and Further Research Outputs
Peer-Reviewed Publications
Bakthavachalu, B. and Huelsmeier, J. and Sudhakaran, I.P. and Hillebrand, J. and Singh, A. and Petrauskas, A. and Thiagarajan, D. and Sankaranarayanan, M. and Mizoue, L. and Anderson, E.N. and Pandey, U.B. and Ross, E. and VijayRaghavan, K. and Parker, R. and Ramaswami, M., RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration, Neuron, 98, (4), 2018, p754-766.e4
Sudhakaran I.P, Ramaswami M, Long-term memory consolidation: The role of RNA-binding proteins with prion-like domains, RNA Biology , 14, (5), 2017, p568-586
Barron, H.C., Vogels, T.P., Behrens, T.E., Ramaswami, M. , Inhibitory engrams in perception and memory , Proceedings of the National Academy of Sciences of the United States of America, 114, (6), 2017, p6666-6674
Kuklin, E.A. and Alkins, S. and Bakthavachalu, B. and Genco, M.C. and Sudhakaran, I. and Raghavan, K.V. and Ramaswami, M. and Griffith, L.C., The long 3â²UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster, Journal of Neuroscience, 37, (44), 2017, p10544-10566
Carreira-Rosario A, Bhargava V, Hillebrand J, Kollipara R.K, Ramaswami M, Buszczak M, Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation, Developmental Cell, 36, (5), 2016, p562 - 571
Choudhury S.D, Mushtaq Z, Reddy-Alla S, Balakrishnan S.S, Thakur R.S, Krishnan K.S, Raghu P, Ramaswami M, Kumar V, Ï
Sarov M, Barz C, Jambor H, Hein M.Y, Schmied C, Suchold D, Stender B, Janosch S, Vinay Vikas K.J, Krishnan R.T, Krishnamoorthy A, Ferreira I.R.S, Ejsmont R.K, Finkl K, Hasse S, KÃ"mpfer P, Plewka N, Vinis E, Schloissnig S, Knust E, Hartenstein V, Mann M, Ramaswami M, VijayRaghavan K, Tomancak P, Schnorrer F, A genome-wide resource for the analysis of protein localisation in Drosophila, eLife, 5, (FEBRUARY), 2016, pe12068-
Kacsoh B.Z, Bozler J, Ramaswami M, Bosco G, Social communication of predator-induced changes in Drosophila behavior and germline physiology, eLife, 4, (MAY), 2015, p07423-
Mullin, A.P., Sadanandappa, M.K., Ma, W., (...), Sanyal, S., Faundez, V. , Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity, Journal of Neuroscience, 35, (1), 2015, p325-338
Kacsoh B.Z, Bozler J, Hodge S, Ramaswami M, Bosco G, A novel paradigm for nonassociative long-term memory in Drosophila: Predator-induced changes in oviposition behavior, Genetics, 199, (4), 2015, p1143 - 1157
Twick, I. , Lee, J.A. , Ramaswami, M, Olfactory habituation in drosophila-odor encoding and its plasticity in the antennal lobe , Progress in Brain Research, 208, 2014, 3-38
Sudhakaran, IP, Hillebrand, J, Dervan, A, Das, S, Holohan, EE, Hulsmeier, J, Sarov, M, Parker, R, VijayRaghavan, K, Ramaswami, M, FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111, (1), 2014, pE99-E108
Ramaswami, M., Network plasticity in adaptive filtering and behavioral habituation, Neuron, 82, (6), 2014, p1216-1229
Sadandappa, MK, Ramaswami, M, Fly model causes neurological rethink, ELIFE, 2, 2013, pe01820-
Redondo, BB, Bunz, M, Halder, P, Sadanandappa, MK, Muhlbauer, B, Erwin, F, Hofbauer, A, Rodrigues, V, VijayRaghavan, K, Ramaswami, M, Rieger, D, Wegener, C, Forster, C, Buchner, E, Identification and Structural Characterization of Interneurons of the Drosophila Brain by Monoclonal Antibodies of the Wurzburg Hybridoma Library, PLOS ONE, 8, (9), 2013, pe75420.-
Sadanandappa, MK, Redondo, BB, Michels, B, Rodrigues, V, Gerber, B, VijayRaghavan, K, Buchner, E, Ramaswami, M, Synapsin Function in GABA-ergic Interneurons Is Required for Short-Term Olfactory Habituation, JOURNAL OF NEUROSCIENCE, 33, (42), 2013, p16576-16585
Ramaswami, M. , Taylor, J.P. , Parker, R, Altered ribostasis: RNA-protein granules in degenerative disorders, Cell, 154, (4), 2013, p727-736
Sudhakaran, I.P., Holohan, E.E., Osman, S., Rodrigues, V., Vijay Raghavan, K., Ramaswami, M., Plasticity of recurrent inhibition in the Drosophila antennal lobe, Journal of Neuroscience , 32, (21), 2012, p7225-7231
Tabone, C.J., Ramaswami, M., Is NMDA Receptor-Coincidence Detection Required for Learning and Memory?, Neuron, 74, (5), 2012, 767-769
Krishnan, K.S., Ramaswami, M., Wu, C.-F..., Obaid Siddiqi at 80 and neurogenetics in India, Journal of Neurogenetics, 26, (3-4), 2012, p255-256
Pradhan, S.J., Nesler, K.R., Rosen, S.F., Kato, Y., Nakamura, A., Ramaswami, M., Barbee, S.A., The conserved p body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction, Journal of Cell Science, 125, (24), 2012, p6105-6116
Paranjpe, P., Rodrigues, V., Raghavan, K.V., Ramaswami, M.., Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons, Learning and Memory, 19, (12), 2012, p627-635
Kangyu Pan, David Corrigan, Jens Hillebrand, Mani Ramaswami, and Anil Kokaram, A wavelet-based Bayesian framework for 3D object segmentation in microscopy, Proceedings of SPIE, 8227, 2012, part. no. 82271O
McCann, C., Holohan, E.E., Das, S., Dervan, A., Larkin, A., Lee, J.A., Rodrigues, V., (...), Ramaswami, M., The ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation, Proceedings of the National Academy of Sciences of the United States of America , 108, (36), 2011, pE655-E662
Pan, K., Kokaram, A., Hillebrand, J., Ramaswami, M.., Gaussian mixtures for intensity modeling of spots in microscopy, 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings , 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings , Rotterdam; Netherland, 14-17 Apr, 2010, pp121-124
Phillips, A.M., Ramaswami, M., Kelly, L.E., Stoned , Traffic, 11, (1), 2010, p16-24
Hillebrand J, Pan K, Kokaram A, Barbee S, Parker R, Ramaswami M, The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons., Frontiers in Neural Circuits, 4, 2010, p121
Pan, K., Kokaram, A., Hillebrand, J., Ramaswami, M., Gaussian mixture models for spots in microscopy using a new split/merge EM algorithm, Proceedings - International Conference on Image Processing, ICIP, 17th IEEE International Conference on Image Processing, ICIP 2010; , Hong Kong, 26-29 Sept, 2010, 3645-3648
Amanda Freeman, Mallory Bowers, Alysia Vrailas Mortimer, Christina Timmerman, Stephanie Roux, Mani Ramaswami and Subhabrata Sanyal, A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila , Brain Research, 1326 , 2010, p15-29
Larkin, A., Karak, S., Priya, R., Das, A., Ayyub, C., Ito, K., Rodrigues, V., Ramaswami, M., Central synaptic mechanisms underlie short-term olfactory habituation in Drosophila larvae, Learning and Memory, 17, (12), 2010, p645-653
Pollock, JD, Ramaswami, M, The Genetics and Epigenetics of Addiction., Journal of Neurogenetics, 2009
Cziko, AM, McCann, CT, Howlett, IC, Barbee, SA, Duncan, RP, Luedemann, R, Zarnescu, D, Zinsmaier, KE, Parker, RR, Ramaswami, M, Genetic Modifiers of DFMR1 Encode RNA-Granule Components in Drosophila., Genetics, 2009
Kumar, V, Fricke, R, Bhar, D, Reddy-Alla, S, Krishnan, KS, Bogdan, S, Ramaswami, M, Syndapin promotes formation of a postsynaptic membrane system in Drosophila., Molecular biology of the cell, 20, (8), 2009, p2254-2264
Chiang, A, Priya, R, Ramaswami, M, Vijayraghavan, K, Rodrigues, V, Neuronal activity and Wnt signaling act through Gsk3-beta to regulate axonal integrity in mature Drosophila olfactory sensory neurons., Development (Cambridge, England), 136, (8), 2009, p1273-1282
Kim, SM, Kumar, V, Lin, YQ, Karunanithi, S, Ramaswami, M, Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse., Proceedings of the National Academy of Sciences of the United States of America, 106, (10), 2009, p4000-4005
Das, S., Larkin, A., Karak, S., Dervan, A., Madhumala, K.S., Pimentel, A., Gandhi, A., Ito, K., Wang, J., Sanyal, S., Rodrigues, V. and Ramaswami, M. , Potentiation of GABAergic interneurons is necessary for short- and long-term forms of olfactory habituation., 2009
Kumar, V, Alla, SR, Krishnan, KS, Ramaswami, M, Syndapin is dispensable for synaptic vesicle endocytosis at the Drosophila larval neuromuscular junction., Molecular and cellular neurosciences, 40, (2), 2009, p234-241
Ramaswami, M, Indian Biological Sciences: Aiming Even Higher, Current Science, 96, (5), 2009, p639 - 640
Wu, CF, Ramaswami, M, The origins of neurogenetics., Journal of Neurogenetics, 21, (4), 2008, p165 - 167
Beckham, C, Hilliker, A, Cziko, AM, Noueiry, A, Ramaswami, M, Parker, R, The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies., Molecular biology of the cell, 19, (3), 2008, p984-993
Kwak, JE, Drier, E, Barbee, SA, Ramaswami, M, Yin, JC, Wickens, M, GLD2 poly(A) polymerase is required for long-term memory., Proceedings of the National Academy of Sciences of the United States of America, 105, (38), 2008, p14644-14649
Hartwig, CL, Worrell, J, Levine, RB, Ramaswami, M, Sanyal, S, Normal dendrite growth in Drosophila motor neurons requires the AP-1 transcription factor., Developmental neurobiology, 68, (10), 2008, p1225-1242
Hillebrand, J., Barbee, S.A., Ramaswami, M. , P-body components, microRNA regulation, and synaptic plasticity , TheScientificWorldJournal , 7, (SUPPL. 2), 2007, p178-190
Activity-dependent regulation of transcription during development of synapses in, editor(s)Ed. Budnik. , Neuromuscular Junctions of Drosophila (II), 2006, [Sanyal, S. and Ramaswami, M.]
Kumar, V, Ramaswami, M, Kissing and pinching: synaptotagmin and calcium do more between bilayers., Neuron, 50, (1), 2006, p3-5
Sanyal S, Jennings T, Dowse H, Ramaswami M, Conditional mutations in SERCA, the sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila, Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology , 176, (3), 2006, p253 - 263
Sanyal, S, Ramaswami, M, Activity-dependent regulation of transcription during development of synapses., International Review of Neurobiology, 75, 2006, p287-305
Barbee, SA, Estes, PS, Cziko, AM, Hillebrand, J, Luedeman, RA, Coller, JM, Johnson, N, Howlett, IC, Geng, C, Ueda, R, Brand, AH, Newbury, SF, Wilhelm, JE, Levine, RB, Nakamura, A, Parker, R, Ramaswami, M, Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies., Neuron, 52, (6), 2006, p997-1009
Gowd, KH, Sabareesh, V, Sudarslal, S, Iengar, P, Franklin, B, Fernando, A, Dewan, K, Ramaswami, M, Sarma, SP, Sikdar, S, Balaram, P, Krishnan, KS, Novel peptides of therapeutic promise from Indian Conidae., Annals of the New York Academy of Sciences, 1056, 2005, p462-473
Etter, PD, Narayanan, R, Navratilova, Z, Patel, C, Bohmann, D, Jasper, H, Ramaswami, M, Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons., BMC Neuroscience, 6, 2005, p39
Sanyal S, Consoulas C, Kuromi H, Basole A, Mukai L, Kidokoro Y, Krishnan KS, Ramaswami M, Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability, Genetics, 169, (2), 2005, p737 - 750
Narayanan, R, Leonard, M, Song, BD, Schmid, SL, Ramaswami, M, An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function., The Journal of Cell Biology, 169, (1), 2005, p117-126
Sanyal S, Kim SM, Ramaswami M, Retrograde regulation in the CNS: Neuron-specific interpretations of TGF-beta signaling, Neuron, 41, (6), 2004, p845 - 848
Menon KP, Sanyal S, Habara Y, Sanchez R, Wharton RP, Ramaswami M, Zinn K, The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor elF-4E, Neuron, 44, (4), 2004, p663 - 676
Ramaswami M, Specifying the age-sensitive component of a short-term memory, Neuron, 40, (5), 2003, p877 - 879
Estes PS, Jackson TC, Stiimson DT, Sanyal S, Kelly LE, Ramaswami M, Functional dissection of a eukaryotic dicistronic gene: Transgenic stonedB, but not stonedA, restores normal synaptic properties to Drosophila stoned mutants, Genetics, 165, (1), 2003, p185 - 196
Hoeffer, CA, Sanyal, S, Ramaswami, M, Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 23, (15), 2003, p6362-6372
Sudarslal S, Majumdar S, Ramasamy P, Dhawan R, Pal PP, Ramaswami M, Lala AK, Sikdar SK, Sarma SP, Krishnan KS, Balaram P, Sodium channel modulating activity in a 5-conotoxin from an Indian marine snail, FEBS Letters, 553, (1-2), 2003, p209 - 212
Rikhy R, Ramaswami M, Krishnan KS, A temperature-sensitive allele of Drosophila sesB reveals acute functions for the mitochondrial adenine nucleotide translocase in synaptic transmission and dynamin regulation, Genetics, 165, (3), 2003, p1243 - 1253
Jackson T, Ramaswami M, Prospects of memory-modifying drugs that target the CREB pathway, Current Opinion in Drug Discovery and Development , 6, (5), 2003, p712-719
Therapeutic Uses of Embryonic Stem Cells in, editor(s)A Chiu and M. Rao. , Human Embryonic Stem Cells., NJ, Humana Press,, 2003, pp297-332 , [Kamb A. Ramaswami M. , and Rao M.S ]
Devaud, JM, Acebes, A, Ramaswami, M, Ferrús, A, Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age., Journal of Neurobiology, 56, (1), 2003, p13-23
Sanyal S, Narayanan R, Consoulas C, Ramaswami M, Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity, BMC Neuroscience, 4, (20), 2003
Narayanan, R, Ramaswami, M, Regulation of dynamin by nucleoside diphosphate kinase., Journal of Bioenergetics and Biomembranes, 35, (1), 2003, p49-55
Etter, PD, Ramaswami, M, The ups and downs of daily life: profiling circadian gene expression in Drosophila., BioEssays : news and reviews in molecular, cellular and developmental biology, 24, (6), 2002, p494-498
Sanyal, S, Ramaswami, M, Spinsters, synaptic defects, and amaurotic idiocy., Neuron, 36, (3), 2002, p335-338
Sanyal, S, Sandstrom, DJ, Hoeffer, CA, Ramaswami, M, AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila., Nature, 416, (6883), 2002, p870-874
Kamb, A, Ramaswami, M, A simple method for statistical analysis of intensity differences in microarray-derived gene expression data., BMC Biotechnology, 1, 2001
Stimson, DT, Estes, PS, Rao, S, Krishnan, KS, Kelly, LE, Ramaswami, M, Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 21, (9), 2001, p3034-3044
Krishnan, KS, Rikhy, R, Rao, S, Shivalkar, M, Mosko, M, Narayanan, R, Etter, P, Estes, PS, Ramaswami, M, Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling., Neuron, 30, (1), 2001, p197-210
Narayanan, R, Ramaswami, M, Endocytosis in Drosophila: progress, possibilities, prognostications., Experimental Cell Research, 271, (1), 2001, p28-35
DeZazzo, J, Sandstrom, D, de Belle, S, Velinzon, K, Smith, P, Grady, L, DelVecchio, M, Ramaswami, M, Tully, T, nalyot, a mutation of the Drosophila myb-related Adf1 transcription factor, disrupts synapse formation and olfactory memory., Neuron, 27, (1), 2000, p145-158
Narayanan, R., Kramer, H . and Ramaswami, M, Drosophila endosomal proteins Hook and Deep orange regulate synapse size but not synaptic vesicle recycling., Journal of Neurobiology, 45, (2), 2000, p105-119
Phillips, A.M., Smith, M., Ramaswami, M. and Kelly, L.E., Interactions between the products of the Drosophila stoned locus and the vesicle-membrane protein, synaptotagmin., Journal of Neuroscience, 20, 2000, p8254-8261
Sohrabji, F, Peeples, KW, Marroquin, OA, Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen., Journal of Neurobiology, 45, (2), 2000, p61-74
Estes, PS, Ho, GL, Narayanan, R, Ramaswami, M, Synaptic localization and restricted diffusion of a Drosophila neuronal synaptobrevin--green fluorescent protein chimera in vivo., Journal of Neurogenetics, 13, (4), 2000, 233-255
Phillips, AM, Smith, M, Ramaswami, M, Kelly, LE, The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 20, (22), 2000, p8254-8261
Endocytosis at the nerve terminal. in, editor(s)Ed. H. Bellen. , Neurotransmitter Release., Oxford University Press. , 1999, pp389-431 , [Zhang, B. and Ramaswami, M. ]
Ito, K, Suzuki, K, Estes, P, Ramaswami, M, Yamamoto, D, Strausfeld, NJ, The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen., Learning & memory (Cold Spring Harbor, N.Y.), 5, (1-2), 1999
Stimson, DT, Ramaswami, M, Vesicle recycling at the Drosophila neuromuscular junction., International review of neurobiology, 43, 1999, p163-187
Vesicle recycling at the Drosophila Neuromuscular junction. in, editor(s)Budnik, V. and Gramates, G. , Neuromuscular Junctions of Drosophila., (USA) , International Reviews of Neurobiology Series. ACADEMIC PRESS , 1999, pp163-189. , [Stimson, D. and Ramaswami, M. ]
Staples, RR, Ramaswami, M, Functional analysis of dynamin isoforms in Drosophila melanogaster., Journal of neurogenetics, 13, (3), 1999, p119-143
Ito, K., Suzuki, K., Estes, P.E., Ramaswami, M., Yamamoto, D. and Strausfeld, N. , The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster meigen , Learning and Memory, 5, (1-2), 1998, p52-77
Lloyd, V, Ramaswami, M, Krämer, H, Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery., Trends in cell biology, 8, (7), 1998, p257-259
Grant, D, Unadkat, S, Katzen, A, Krishnan, KS, Ramaswami, M, Probable mechanisms underlying interallelic complementation and temperature-sensitivity of mutations at the shibire locus of Drosophila melanogaster., Genetics, 149, (2), 1998, p1019-1030
Ramaswami, M. , How "carrots and sticks" are encoded in the brain: motivation, reward, addiction and fear., Journal of Bioscience, 23, (3), 1998, p163-164.
Stimson, DT, Estes, PS, Smith, M, Kelly, LE, Ramaswami, M, A product of the Drosophila stoned locus regulates neurotransmitter release., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 18, (23), 1998, p9638-9649
Mir, B, Iyer, S, Ramaswami, M, Krishnan, KS, A genetic and mosaic analysis of a locus involved in the anesthesia response of Drosophila melanogaster., Genetics, 147, (2), 1997, p701-712
Krishnan, KS, Chakravarty, S, Rao, S, Raghuram, V, Ramaswami, M, Alleviation of the temperature-sensitive paralytic phenotype of shibire(ts) mutants in Drosophila by sub-anesthetic concentrations of carbon dioxide., Journal of Neurogenetics, 10, (4), 1996, p221-228
Estes, PS, Roos, J, van der Bliek, A, Kelly, RB, Krishnan, KS, Ramaswami, M, Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers., The Journal of Neuroscience : the official journal of the Society for Neuroscience, 16, (17), 1996, p5443-5456
Van de Goor, J., Ramaswami, M. and Kelly, R.B., Redistribution of synaptic vesicles and their proteins in shibirets1 mutant Drosophila., Proceedings of the National Academy of Sciences of the United States of America, 92, (12), 1995, p5739-5743
Endocytotic pathways in neurons. in, editor(s)K.S. Kosick et al. , Alzheimer's Disease: Lessons from Cell Biology, Research and Perspectives in Alzheimer's Disease, Berlin Heidelberg, Springer Verlag , 1995, pp1-13. , [Grote, E., Bonzelius, F., Herman, G., Ramaswami, M., van de Goor, J., Green, S. and Kelly, R.B]
Pallanck, L, Ordway, RW, Ramaswami, M, Chi, WY, Krishnan, KS, Ganetzky, B, Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog., The Journal of Biological Chemistry, 270, (32), 1995, p18742-18744
Pavlidis, P, Ramaswami, M, Tanouye, MA, The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis., Cell, 79, (1), 1994, p23-33
Ramaswami, M., Krishnan, K.S. and Kelly, R.B, Intermediate stages in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions, Neuron, 13, 1994, p363-375
Ramaswami, M, Tanouy, M, Mathew, MK, Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs., Indian Journal of Biochemistry & Biophysics, 31, (4), 1994, p254-260
Ramaswami, M, Tanouye, M.A and Mathew, M.K , Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs., Indian Journal of Biochemistry & Biophysics, 31, (4), 1994, p254-260
Ramaswami, M, Krishnan, KS, Kelly, RB, Intermediates in synaptic vesicle recycling revealed by optical imaging of Drosophila neuromuscular junctions., Neuron, 13, (2), 1994, p363-375
Ramaswami, M., Rabid roles in vesicle fusion., Current Science, 64, (4), 1993, p214
Ramaswami, M, Rao, S, van der Bliek, A, Kelly, RB, Krishnan, KS, Genetic studies on dynamin function in Drosophila., Journal of Neurogenetics, 9, (2), 1993, p73-87
Ramaswami, M., Voltage-Gated Channels: Perspectives and Progress., Current Science, 62, 1992, p341-354
Ramaswami, M., The Nobel Prize in Physiology and Medicine. , 1991, - 20.
McCormack, K.J., Iverson, L., Lin, J.W., Ramaswami, M., Mathew, M.K., McCormack, T.J., Rudy, B., and Tanouye, M.A., Mutagenesis of a leucine heptad repeat involved in voltage-dependent gating of Shaker potassium channels., Proceedings of the National Academy of Sciences of the United States of America, 88, 1991, p2931-2935.
Ramaswami, M., Gautam, M., Kamb, C.A., Rudy, B., Tanouye, M.A. and Mathew, M.K. , Human potassium channel genes: molecular cloning and functional expression. , Molecular Cell Neuroscience, 1, (3), 1990, p214-223.
Ramaswami, M. , Molecular genetic studies on voltage-gated ion channels., 1990, -
Ramaswami, M, Tanouye, MA, Two sodium-channel genes in Drosophila: implications for channel diversity., Proceedings of the National Academy of Sciences of the United States of America, 86, (6), 1989, p2079-2082
Drosophila homologs of vertebrate sodium channel genes. in, editor(s)R.N.Singh and N. J. Strausfeld , The Neurobiology of Sensory Systems., NY, Plenum , 1989, pp449-467. , [Ramaswami, M., Lashgari, A. and Tanouye, M.A. ]
McCormack, K.J., Campanelli, J.T., Ramaswami, M., Mathew, M.K., Tanouye, M.A., Iverson, L.E. and Rudy, B., Leucine-zipper motif update., Nature, 340, 1989, p103-104
Research Expertise
Description
Research interests My laboratory is interested in understanding molecular and circuit mechanisms of simple learned behaviors. We use the genetic model organism Drosophila melanogaster to study fundamental synaptic mechanisms as well as mechanisms of simple olfactory memory. An obvious extension of these studies to ask how these mechanisms are affected in disease and we currently study disease models for fragile-X mental retardation and spinocerebellar ataxia. Five post-doctoral researchers and three postgraduate students in my lab use many in vivo approaches including Drosophila genetics, two-photon microscopy based live-brain imaging, electrophysiology, and a range of cell biological, behavioral & molecular techniques. Several collaborations, particularly with top research groups in India and the US, expand our work into other fields such as natural products and peptide neurotoxins. Recent advances in the lab include the following. 1. Primarily in collaboration with Veronica Rodrigues' group in the NCBS, Bangalore, we have discovered that gene expression- and synaptic growth dependent potentiation of GABAergic neurons drives specific forms of learned olfactory behavior. 2. In collaboration with Roy Parker at the University of Arizona, we have found that that proteins and mechanisms that control translation of mRNAs in yeast, also regulate the translation of mRNAs stored in synapses. Some of these regulatory mechanisms, required for proper neuronal homeostasis/plasticity are required for miRNA function and altered in human neurological disease.Projects
- Title
- Science Foundation of Ireland Investigator
- Summary
- Date From
- 2007
- Date To
- 2011
- Title
- Wellcome Trust Cellular and genetic analysis of synapse assembly and function (Project Grant)
- Summary
- Role PI
- Funding Agency
- Wellcome Trust
- Date From
- 2006
- Date To
- 2008
- Title
- Dept of Biotechnology, Govt of India. Circuit mechanisms of long-term habituation
- Summary
- Role: Collaborator (PI: Veronica Rodrigues)
- Title
- Deep sequencing of venom duct cDNAs from Indian cone snails
- Summary
- Dept of Biotechnology, Govt of India. Role: Collaborator (PI: K.S. Krishnan)
- Title
- Science Foundation of Ireland Research Professor.
- Summary
- Date From
- 2005
- Date To
- 2007
- Title
- Fos, Jun and the transcriptional control of synaptic plasticity.
- Summary
- Funding Agency
- NIH/NIDA (RO1):
- Date From
- March '03
- Date To
- Feb '08
- Title
- Fos, Jun and the transcriptional control of synaptic plasticity
- Summary
- (Career Development Award).
- Funding Agency
- NIDA (K02)
- Date From
- Sept 2004
- Date To
- August 2010.
- Title
- Molecular mechanisms of synaptic-vesicle recycling.
- Summary
- Funding Agency
- NIH/NINDS (RO1)
- Date From
- April '01
- Date To
- Mar.'05
- Title
- Identification of Drosophila proteins modified by neural activity: a proteomic and genetic approach.
- Funding Agency
- NIH/NIDA (R21)
- Date From
- April '02
- Date To
- Mar '04
- Title
- Analysis of the pathway of SPIRE, an actin-binding protein.
- Summary
- March of Dimes
- Date From
- March'03
- Date To
- May '04
- Title
- A novel technology for protein delivery to the CNS.
- Summary
- (Small Business Innovation Research Grant to Q. Therapeutics)
- Funding Agency
- NIH/NINDS (R43)
- Title
- Molecular mechanisms of synaptic-vesicle recycling
- Summary
- Funding Agency
- NIH/NINDS (RO1)
- Date From
- Mar. 1997
- Date To
- Feb. 2001
- Title
- Novel technologies for identification and analysis of genes involved in long-term neural plasticity.
- Summary
- Funding Agency
- NIH/ NIDA (RO1)
- Date From
- Oct. 1999
- Date To
- Sept. 2002
- Title
- Molecular Mechanisms of synaptic vesicle recycling
- Summary
- (Career Development Award)
- Funding Agency
- NIH/ NIMH (K02)
- Date From
- Sept.1997
- Date To
- Aug. 2002
- Title
- Dissection of molecular and cellular mechanisms underlying neural plasticity in the fruit fly and the honey bee..
- Funding Agency
- HFSPO
- Date From
- 1999
- Date To
- 2003
- Title
- McKnight Award
- Summary
- Genetic analysis of presynaptic mechanisms.
- Date From
- 1995
- Date To
- 1997
- Title
- Sloan Award
- Summary
- Genetic analysis of presynaptic mechanisms.
- Date From
- 1995
- Date To
- 1998.
- Title
- In vivo analysis of dynamin function in synaptic vesicle recycling.
- Summary
- Funding Agency
- NSF
- Date From
- 1995
- Date To
- 1998.
- Title
- A genetic and cellular analysis of synaptic function in Drosophila.
- Funding Agency
- HFSPO
- Date From
- 1995
- Date To
- 1998
Recognition
Awards and Honours
Professorial Fellowship, Trinity College Dublin.
Galileo Circle Fellow, College of Science, University of Arizona.
NIDA K (Career Development/ Research Leave) Award. (declined in 2008)
Cutting Edge Brain Research Award (CEBRA) from the NIDA.
Early Tenure, University of Arizona
HFSPO Research Grant Award
NIH Research Career Development Award
McKnight Scholar's Award in Neuroscience
Alfred P. Sloan Fellowship in Neuroscience
HFSPO Research Grant Award
Life Science Research Foundation Fellowship
HFSPO Long-Term Fellowship
Associate of the Indian Academy of Sciences
Proctor and Gamble Research Fellowship
Markey Charitable Trust Fellowship
Evelyn Sharp Graduate Fellowship
The Institute Silver Medal (for the best student of Chemistry) Indian Institute of Technology, New Delhi
Arthur McCallum Graduate Fellowship