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Dr. Alastair Fleming
Assistant Professor/ Head of Discipline, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Kröger C, Schauer K, Clerkin S, Maertlbauer E and Fleming AB, Draft Genome Sequence and Annotation of Acinetobacter junii MHI21018, Isolated from Bovine Colostrum, Microbiology Resource Announcements, 2019 Journal Article, 2019 DOI

Young, Conor P and Hillyer, Cory and Hokamp, Karsten and Fitzpatrick, Darren J and Konstantinov, Nikifor K and Welty, Jacqueline S and Ness, Scott A and Werner-Washburne, Margaret and Fleming, Alastair B and Osley, Mary Ann, Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast, BMC genomics, 18, (1), 2017, p107 Journal Article, 2017 DOI

Church MC, Fleming AB, A role for histone acetylation in regulating transcription elongation., Transcription, 2017 Review Article, 2017 DOI

Church M, Smith KC, Alhussain MM, Pennings S, Fleming AB., Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene, Nucleic Acids Research, 45, (8), 2017, p4413 - 4430 Journal Article, 2017 URL

Conor Young, Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae, Trinity College Dublin, 2015 Thesis, 2015

Michael Church, Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Trinity College Dublin, 2015 Thesis, 2015

Fleming, AB, Beggs S, Church M, Tsukihashi Y, Pennings S., The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene., Biochim Biophys Acta - Gene regulatory Mechanisms, 1839, (11), 2014, p1242 - 1255 Journal Article, 2014 TARA - Full Text DOI

Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB, Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP, Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits., PLoS genetics, 10, (10), 2014, pe1004658 Journal Article, 2014 DOI URL TARA - Full Text

Shieh, G.S., Pan, C.-H., Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., (...), Kao, C.-F., H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast, BMC Genomics, 12, 2011, part. no. 627 Journal Article, 2011 DOI TARA - Full Text

Artem Barski, Iouri Chepelev, Joanna Birch, Suresh Cuddapah, Alastair B. Fleming, Dritan Liko, Kairong Cui, Robert J. White and Keji Zhao, Pol II and its associated epigenetic marks co-localize throughout the genome with pol III-transcribed non-coding RNA genes, Nature Molecular & Structural Biology, 17, (5), 2010, p629-634 Journal Article, 2010 DOI

Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA., H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, Molecular Cell, 31, (1), 2008, p57 - 66 Journal Article, 2008 DOI

Alastair Fleming and Sari Pennings, Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene., Nucleic Acids Research, 35, (16), 2007, p5520 - 5531 Journal Article, 2007 TARA - Full Text DOI

Osley MA, Fleming AB, Kao CF., Histone ubiquitylation and the regulation of transcription., Results and Problems in Cell Differentiation, 41, (2006), 2007, p47 - 75 Journal Article, 2007 DOI

Tsukuda T, Fleming AB, Nickoloff JA, Osley MA., Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae., Nature, 438, (7066), 2005, p379 - 383 Journal Article, 2005 DOI

Fleming A, Osley MA., Silence of the rings., Cell, 119, (4), 2004, p449 - 451 Journal Article, 2004 DOI

Fleming AB, Pennings S., Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation., Yeast, XXth YGM Conference, Prague, Czech Republic, August 26-31, 18, 2001, pp95 - 96 Conference Paper, 2001 URL

Fleming, A.B. and Pennings, S. , Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation, EMBO Journal, 20, (18), 2001, p5219 - 5230 Journal Article, 2001 DOI

Tangney, M., Fleming, A.B., Jorgensen, and Priest, F.G, You have full text access to this OnlineOpen articleRegulation of maltose metabolism in stationary phase cultures of an asporogenous mutant of Bacillus licheniformis , Journal of Applied Microbiology, 84, (2), 1998, p201 - 206 Journal Article, 1998 DOI

Fleming AB, Tangney M, Jørgensen PL, Diderichsen B, Priest FG., Extracellular enzyme synthesis in a sporulation-deficient strain of Bacillus licheniformis., Applied and environmental microbiology, 61, (11), 1995, p3775 - 3780 Journal Article, 1995 TARA - Full Text URL

Non-Peer-Reviewed Publications

Alastair Fleming, The epigenetic landscape of quiscent yeast cells, Irish Fungal Society Meeting, 11-12 June, 2015 Invited Talk, 2015

Alastair Fleming, The epigenetic landscape of quiescent yeast cells. , University of Maynooth, 13 Feb, 2015 Invited Talk, 2015

Alastair Fleming, Ursula Bond, Gary Moran and Derek Sullivan, Irish Fungal Society Meeting, 11-12 June , 2015, Trinity College Dublin Meetings /Conferences Organised, 2015

Michael Church and Alastair Fleming, Investigating FLO1 gene regulation by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Irish Fungal Society Meeting, NUI Galway, 19-20 June, 2014, Irish Fungal Society Invited Talk, 2014

Suzanne Beggs and Alastair Fleming, Investigating nucleosome dynamics during transcription elongation in Saccharomyces cerevisiae, EMBO Gene Transcription in Yeast, Sant Feliu de Guíxols, Spain, 14-19 June, 2014 Poster, 2014

Alastair Fleming, Conor Young, Cory Hillyer and Mary Ann Osley, The histone modification landscape of quiescent yeast cells formed during chronological aging, Keystone Conference in Cancer Epigenetics, Santa Fe, New Mexico, USA, 20-24 March, 2013 Poster, 2013

Alastair Fleming, Chromatin remodelling during yeast stationary phase, University of Cork, 2012 Invited Talk, 2012

Cory Hillyer, Nikifor Konstantinov, Alastair B. Fleming, and Mary Ann Osley , Histone modification patterns during development of budding yeast stationary phase, Signalling to Chromatin, Cambridge, UK, 7th - 10th Sept 2010, edited by Wellcome Trust , 2010 Poster, 2010

Alastair Fleming, Interplay between H2B ubiquitylation and histone chaperones during transcription, Scottish Chromatin Group, MRC, Edinburgh, UK, 24 th October, 2007, Scottish Chromatin Group Invited Talk, 2007

Alastair Fleming, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, CMBS seminar series, University of St. Andrews, 10th September, 2007 Invited Talk, 2007

Alastair Fleming, Different roles for H2B ubiquitylation and H3 methylation during gene transcription in yeast, Edinburgh Systems Biology Group Meeting, University of Edinburgh, 1 November, 2007 Invited Talk, 2007

Fleming, A.B., Kao, C.K., Hillier, C., Pickaart, M. and Osley, M. A, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, FASEB, Chromatin and transcription, Snowmass, Colorado, USA, July 7th - 12th, 2007 Poster, 2007

Research Expertise


Cancer Biology; CHROMATIN; DNA; Gene Expression; Gene Regulation; Genetic Manipulation; Genetics; GENOME ORGANIZATION; Genomes, Genomics; Molecular Biology; Molecular Genetics; Nucleic Acid Structure/Function; Nucleic Acids; Recombinant DNA; TRANSCRIPTION; YEAST



Microbiology Society 2010 – 2018