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Matthew Campbell
, Genetics
, Trinity Inst. of Neurosciences (TCIN)

Publications and Further Research Outputs

Peer-Reviewed Publications

Doherty, C.P., O'Keeffe. E., Keaney, J., Lawlor, B.A., Coen, R.F., Farrell, M., Campbell, M., Neuropolypathology as a result of severe traumatic brain injury? , Clinical Neuropathology, 2019, p14-22 Journal Article, 2019 DOI

Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbroucke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Correction: Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017 [Fluids Barriers CNS 14, (2017) (31)] DOI: 10.1186/s12987-017-0079-9, Fluids and Barriers of the CNS, 15, (1), 2018, p3- Journal Article, 2018 DOI TARA - Full Text

Kealy, J. and Greene, C. and Campbell, M., Blood-brain barrier regulation in psychiatric disorders, Neuroscience Letters, 2018 Journal Article, 2018 DOI TARA - Full Text

Campbell, M. and Cassidy, P.S. and O'Callaghan, J. and Crosbie, D.E. and Humphries, P., Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension, Progress in Retinal and Eye Research, 62, 2018, p120-133 Journal Article, 2018 DOI TARA - Full Text

C Greene, J Kealy, M M Humphries, Y Gong, J Hou, N Hudson, L M Cassidy, R Martiniano, V Shashi, S R Hooper, G A Grant, P F Kenna, K Norris, C K Callaghan, M dN Islam, S M O'Mara, Z Najda, S G Campbell, J S Pachter, J Thomas, N M Williams, P Humphries, K C Murphy, M Campbell, Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia, Molecular Psychiatry, 2017 Journal Article, 2017 DOI

Delaney, C. and Campbell, M., The blood brain barrier: Insights from development and ageing, Tissue Barriers, 5, (4), 2017, pe1373897 - Journal Article, 2017 DOI

Theodoropoulou S, Copland D.A, Liu J, Wu J, Gardner P.J, Ozaki E, Doyle S.L, Campbell M, Dick A.D, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, Journal of Pathology, 241, (1), 2017, p45 - 56 Journal Article, 2017 URL DOI

Menard, C. and Pfau, M.L. and Hodes, G.E. and Kana, V. and Wang, V.X. and Bouchard, S. and Takahashi, A. and Flanigan, M.E. and Aleyasin, H. and Leclair, K.B. and Janssen, W.G. and Labonté, B. and Parise, E.M. and Lorsch, Z.S. and Golden, S.A. and Heshmati, M. and Tamminga, C. and Turecki, G. and Campbell, M. and Fayad, Z.A. and Tang, C.Y. and Merad, M. and Russo, S.J., Social stress induces neurovascular pathology promoting depression, Nature Neuroscience, 20, (12), 2017, p1752-1760 Journal Article, 2017 DOI

O'Callaghan, J. and Crosbie, D.E. and Cassidy, P.S. and Sherwood, J.M. and FlÃŒgel-Koch, C. and LÃŒtjen-Drecoll, E. and Humphries, M.M. and Reina-Torres, E. and Wallace, D. and Kiang, A.-S. and Campbell, M. and Stamer, W.D. and Overby, D.R. and O'Brien, C. and Tam, L.C.S. and Humphries, P., Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, 26, (7), 2017, p1230-1246 Journal Article, 2017 DOI

Shah T.M, Gupta S.M, Chatterjee P, Campbell M, Martins R.N, Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer†s disease, Molecular Psychiatry, 22, 2017, p353-363- Journal Article, 2017 URL DOI

Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbrouke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017, Fluids and Barriers of the CNS, 14, (1), 2017, p31- Journal Article, 2017 DOI TARA - Full Text

Tam L.C.S, Reina-Torres E, Sherwood J.M, Cassidy P.S, Crosbie D.E, LÃ"tjen-Drecoll E, FlÃ"gel-Koch C, Perkumas K, Humphries M.M, Kiang A.-S, O'Callaghan J, Callanan J.J, Read A.T, Ethier C.R, O'Brien C, Lawrence M, Campbell M, Stamer W.D, Overby D.R, Humphries P, Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia, Scientific Reports, 7, 2017, p40717- Journal Article, 2017 TARA - Full Text URL DOI

Oleszycka, E., Moran, H.B.T., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J. and Lavelle, E.C. , IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination. , FEBS Journal, 283, (1), 2016, p9 - 24 Journal Article, 2016 DOI

Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662 Journal Article, 2016 URL DOI

5. S Theodoropoulou, S Doyle, D Copland, J Liu, J Wu, M Campbell, A Dick, Interleukin 33/ST2 signaling regulates inflammatory response in choroidal stroma and ocular angiogenesis: implications for age‐related macular degeneration., Acta Ophthalmologica, 93, (S255), 2016 Conference Paper, 2016

O'Keeffe E, Campbell M, Modulating the paracellular pathway at the bloodâ€"brain barrier: current and future approaches for drug delivery to the CNS, Drug Discovery Today: Technologies, 20, 2016, p35 - 39 Journal Article, 2016 URL DOI

Greene C, Campbell M, Tight junction modulation of the blood brain barrier: CNS delivery of small molecules, Tissue Barriers, 4, (1), 2016, pe1138017- Journal Article, 2016 DOI URL

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203 Journal Article, 2015 DOI TARA - Full Text

Abrahams J.L, Packer N.H, Campbell M.P, Relative quantitation of multi-antennary N-glycan classes: Combining PGC-LC-ESI-MS with exoglycosidase digestion, Analyst, 140, (16), 2015, p5444 - 5449 Journal Article, 2015 DOI URL

Ranzinger R, Aoki-Kinoshita K.F, Campbell M.P, Kawano S, Lütteke T, Okuda S, Shinmachi D, Shikanai T, Sawaki H, Toukach P, Matsubara M, Yamada I, Narimatsu H, GlycoRDF: An ontology to standardize glycomics data in RDF, Bioinformatics, 31, (6), 2015, p919 - 925 Journal Article, 2015 URL DOI TARA - Full Text

Campbell M.P, Royle L, Rudd P.M, Glycobase and autoGU: Resources for interpreting HPLC-glycan data, Glycoinformatics: Methods in Molecular Biology, 1273, 2015, 17-28 Journal Article, 2015 URL DOI

Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M, IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates., Invest Ophthalmol Vis Sci, 56, (9), 2015, p5424-30 Journal Article, 2015 DOI

Ozaki E, Campbell M, Doyle S.L, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives, Journal of Inflammation Research, 8, 2015, p15 - 27 Journal Article, 2015 TARA - Full Text DOI URL

Keaney J, Campbell M, The dynamic blood-brain barrier, FEBS Journal, 282, (21), 2015, p4067 - 4079 Journal Article, 2015 DOI URL

Doyle SL, López FJ, Humphries P, Adamson P, Campbell M, Author Response: The Role of IL-18 in the Treatment of AMD., Invest Ophthalmol Vis Sci, 56, (3), 2015, p8237-8 Journal Article, 2015 DOI

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M., Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier., Science Advances, 1, (8), 2015, p10.1126/sci adv.1500472 Journal Article, 2015

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

Campbell, M., Doyle, S., Humphries, P. , IL-18: A new player in immunotherapy for age-related macular degeneration?, Expert Review of Clinical Immunology, 10, (10), 2014, p1273-1275 Journal Article, 2014 DOI

Hudson N, Powner M.B, Sarker M.H, Burgoyne T, Campbell M, Ockrim Z.K, Martinelli R, Futter C.E, Grant M.A, Fraser P.A, Shima D.T, Greenwood J, Turowski P, Differential apicobasal VEGF signaling at vascular blood-neural barriers, Developmental Cell, 30, (5), 2014, p541 - 552 Journal Article, 2014 URL TARA - Full Text DOI

Doyle S.L, Adamson P, López F.J, Humphries P, Campbell M, Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration, Nature Medicine, 20, (12), 2014, p1376 - 1377 Journal Article, 2014 DOI URL

7. S Doyle, PS Adamson, FJ Lopez, P Humphries, M Campbell , IL-18 promotes wound healing and has anti-angiogenic properties in the eye., Investigative Ophthalmology & Visual Science, ARVO, Orlando, 56 (7), , 2014, pp2462-2462 Conference Paper, 2014

Kiang, A.S., Humphries, M.M., Campbell, M., Humphries, P. , Antioxidant therapy for retinal disease., Advances in experimental medicine and biology, 801, 2014, p783-789 Journal Article, 2014 DOI

Nguyen, A.T., Campbell, M., Kiang, A.S., Humphries, M.M., Humphries, P. , Current therapeutic strategies for P23H RHO-linked RP., Advances in experimental medicine and biology, 801, 2014, p471-476 Journal Article, 2014 DOI

Ozaki, E., Campbell, M., Kiang, A.S., (...), Doyle, S.L., Humphries, P. , Inflammation in age-related macular degeneration., Advances in experimental medicine and biology, 801, 2014, p229-235 Journal Article, 2014 DOI

York W.S, Agravat S, Aoki-Kinoshita K.F, Mcbride R, Campbell M.P, Costello C.E, Dell A, Feizi T, Haslam S.M, Karlsson N, Khoo K.-H, Kolarich D, Liu Y, Novotny M, Packer N.H, Paulson J.C, Rapp E, Ranzinger R, Rudd P.M, Smith D.F, Struwe W.B, Tiemeyer M, Wells L, Zaia J, Kettner C, MIRAGE: The minimum information required for a glycomics experiment, Glycobiology, 24, (5), 2014, p402 - 406 Journal Article, 2014 DOI URL

Doyle, S.L., Adamson, P., López, F.J., Humphries, P., Campbell, M. , Interleukin-18 bioactivity and dose: Data interpretation at a crossroads, Investigative Ophthalmology and Visual Science, 55, (12), 2014, p8349 Journal Article, 2014 DOI

Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230- Journal Article, 2014 DOI TARA - Full Text

Campbell, M., Doyle, S.L., Ozaki, E., (...), Humphries, M.M., Humphries, P. , An overview of the involvement of interleukin-18 in degenerative retinopathies., Advances in experimental medicine and biology, 801, 2014, p409-415 Journal Article, 2014 DOI

Campbell M, Doyle SL, An eye on the future of inflammasomes and drug development in AMD., Journal of molecular medicine (Berlin, Germany), 91, (9), 2013, p1059-70 Journal Article, 2013 DOI

Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Jane Farrar G, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy., European journal of human genetics : EJHG, 21, (1), 2013, p62-8 Journal Article, 2013 DOI TARA - Full Text

Rouine, J, Gobbo, OL, Campbell, M, Gigliucci, V, Ogden, I, Smith, KM, Duffy, P, Behan, B, Byrne, D, Kelly, ME, Blau, CW, Kerskens, CM, Harkin, A, MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI, BRITISH JOURNAL OF PHARMACOLOGY, 169, (5), 2013, p974-987 Journal Article, 2013 TARA - Full Text DOI

9. M Campbell, E Ozaki, MM Humphries, PS Adamson, P Humphries, NLRP3 independent mechanisms of RPE cell death, Investigative Ophthalmology & Visual Science, ARVO, Seattle, 55 (13), 2013, pp1318-1318 Conference Paper, 2013

Barrier modulation in drug delivery to the retina. in, Retinal Degeneration, 2013, pp371-80 , [Campbell M, Humphries MM, Humphries P] Book Chapter, 2013 DOI

Humphries P, Humphries MM, Tam LC, Farrar GJ, Kenna PF, Campbell M, Kiang A-S. , Hereditary retinopathies: progress in development of genetic and molecular therapies., SpringerBriefs in Genetics, Springer NY. , 2013 Book, 2013

Campbell M, Humphries P, The blood-retina barrier: tight junctions and barrier modulation., Advances in experimental medicine and biology, 763, 2012, p70-84 Journal Article, 2012 DOI

Hanrahan, F, Campbell, M, Nguyen, AT, Suzuki, M, Kiang, AS, Tam, LC, Gobbo, OL, Dhubhghaill, SN, Humphries, MM, Kenna, PF, Humphries, P, LaVail, MM, Ash, JD, Anderson, RE, Hollyfield, JG, Grimm, C, On Further Development of Barrier Modulation as a Technique for Systemic Ocular Drug Delivery, RETINAL DEGENERATIVE DISEASES, 723, 2012, p155-159 Journal Article, 2012 DOI

Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., (...), Zuckerbraun, B., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, (4), 2012, p445-544 Review Article, 2012 DOI

Nguyen AT, Campbell M, Kenna PF, Kiang AS, Tam L, Humphries MM, Humphries P, Calpain and photoreceptor apoptosis., Advances in experimental medicine and biology, 723, 2012, p547-52 Journal Article, 2012 DOI

Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849 Journal Article, 2012 DOI

Tam LC, Kiang AS, Campbell M, Keaney J, Farrar GJ, Humphries MM, Kenna PF, Humphries P, Protein misfolding and potential therapeutic treatments in inherited retinopathies., Advances in experimental medicine and biology, 723, 2012, p567-72 Journal Article, 2012 DOI

Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M, Kiang AS, Humphries P, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European journal of human genetics : EJHG, 20, (1), 2012, p64-8 Journal Article, 2012 DOI

Campbell*, M, Doyle*, SL, Ozaki, E, Salomon, RG, Mori, A, Kenna, PF, Kiang, AS, Humphries, MM, Lavelle, EC, O'Neill, LAJ, Hollyfield, JG, and Humphries, P, NLRP3 plays a protective role during the development of age related macular degeneration through the induction of IL-18 by drusen components., Nature Medicine, 18, (5), 2012, p791 - 798 Journal Article, 2012 DOI

Bowne, SJ, Humphries, MM, Sullivan, LS, Kenna, PF, Tam, LCS, Kiang, AS, Campbell, M, Weinstock, GM, Koboldt, DC, Ding, L, Fulton, RS, Sodergren, EJ, Allman, D, Millington-Ward, S, Palfi, A, McKee, A, Blanton, SH, Slifer, S, Konidari, I, Farrar, GJ, Daiger, SP, Humphries, P, A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement, EUROPEAN JOURNAL OF HUMAN GENETICS, 19, (10), 2011, p1074-1081 Journal Article, 2011 DOI

Campbell M, Humphries MM, Nguyen ATH, Gobbo OL, Tam LCS, Suzuki M, Hanrahan F, Ozaki E, Farrar G-J, Kiang A-S, Kenna PF, Humphries P. , Systemic low-molecular weight drug delivery to pre-selected neuronal regions, EMBO Molecular Medicine, 3, (4), 2011, p235-245 Journal Article, 2011 TARA - Full Text

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE, Wnt signaling mediates pathological vascular growth in proliferative retinopathy., Circulation, 124, (17), 2011, p1871-81 Journal Article, 2011 DOI

Dagdan E, Morris D, Campbell M, Hill M, Rothermundt M, Kastner F, Hofoff C, Von Eiff, Krakowitzky P, Gill M, McKeon P, Roche S, Functional Assessment of a Promoter Polymorphism in S100B, a putative Risk Variant for Bipolar Disorder, Neuropsychiatric Genetics, 156, (6), 2011, p691 - 699 Journal Article, 2011 DOI

Bowne, S.J., Humphries, M.M., Sullivan, L.S., Kenna, P.F., Tam, L.C.S., Kiang, A.S., Campbell, M., (...), Humphries, P. , Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (European Journal of Human Genetics (2011) 19 (1074-1081) DOI: 10.1038/ejhg.2011.86), 2011, - 1109 Miscellaneous, 2011 DOI

Campbell M, Humphries P, Size-selective and in vitro assessment of inner blood retina barrier permeability., Methods in molecular biology (Clifton, N.J.), 763, 2011, p355-67 Journal Article, 2011 DOI

Keaney J, Campbell M, Humphries P, From RNA interference technology to effective therapy: how far have we come and how far to go?, Therapeutic delivery, 2, (11), 2011, p1395-406 Journal Article, 2011 DOI

Hanrahan, F., Humphries, P., Campbell, M., RNAi-mediated barrier modulation: Synergies of the brain and eye, Therapeutic Delivery , 1, (4), 2010, p587-594 Journal Article, 2010 DOI

Ni Dhubhghaill SS, Cahill MT, Campbell M, Cassidy L, Humphries MM, Humphries P, The pathophysiology of cigarette smoking and age-related macular degeneration., Advances in Experimental Medicine and Biology, 664, (Part 4), 2010, p437-46 Journal Article, 2010 DOI

Campbell M, Ozaki E, Humphries P, Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach., Expert Opinion on Drug Delivery, 7, (7), 2010, p859-69 Journal Article, 2010 DOI

Campbell M, Nguyen AT, Kiang AS, Tam L, Kenna PF, Dhubhghaill SN, Humphries M, Farrar GJ, Humphries P, Reversible and size-selective opening of the inner Blood-Retina barrier: a novel therapeutic strategy., Advances in Experimental Medicine and Biology, 664, (Part 3), 2010, p301-8 Journal Article, 2010 DOI

Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P, Protection of photoreceptors in a mouse model of RP10., Advances in Experimental Medicine and Biology, 664, (Part 5), 2010, p559-65 Journal Article, 2010 DOI

Lawrence C. S. Tam, Anna-Sophia Kiang, Matthew Campbell, James Keaney, G. Jane Farrar, Marian M. Humphries, Paul F. Kenna and Pete Humphries, Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Human Molecular Genetics, 19, (22), 2010, p4421-4436 Journal Article, 2010 TARA - Full Text

O. Gobbo, M. Campbell, A.Kiang, P. Kenna, C. Kerskens, G. J. Farrar, P. Humphries, RNAi-MEDIATED REVERSIBLE OPENING OF THE BLOOD-BRAIN AND BLOODRETINA BARRIER, MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Matthew Campbell, Anh T. H. Nguyen, Anna-Sophia Kiang, Lawrence C. S. Tam, Oliviero L. Gobbo, Christian Kerskens, Sorcha Ni Dhubhghaill, Marian M. Humphries, G.-Jane Farrar, Paul F. Kenna and Peter Humphries, An experimental platform for systemic drug delivery to the retina, Proceedings of the National Academy of Sciences of the United States, 106, (42), 2009, p17817 - 17822 Journal Article, 2009 DOI TARA - Full Text

Campbell, M, Kiang, AS, Kenna, PF, Kerskens, C, Blau, C, O'Dwyer, L, Tivnan, A, Kelly, JA, Brankin, B, Farrar, GJ, Humphries, P, RNAi-mediated reversible opening of the blood-brain barrier., The Journal of Gene Medicine, 10, (8), 2008, p930 - 947 Journal Article, 2008 DOI

Tam, LC, Kiang, AS, Kennan, A, Kenna, PF, Chadderton, N, Ader, M, Palfi, A, Aherne, A, Ayuso, C, Campbell, M, Reynolds, A, McKee, A, Humphries, MM, Farrar, GJ, Humphries, P, Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)., Human Molecular Genetics, 17, (14), 2008, p2084-2100 Journal Article, 2008 TARA - Full Text DOI

Campbell, M, Humphries, M, Kenna, P, Humphries, P, Brankin, B, Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse., Experimental Eye Research, 85, (5), 2007, p714-720 Journal Article, 2007 DOI

Campbell M, Humphries MM, Kennan A, Kenna PF, Humphries P and Brankin B., Aberrant Retinal Tight Junction and Adherens junction protein expression in an animal model of autosomal recessive retinitis pigmentosa: The Rho (-/-) mouse, Exp. Eye Res, 83, (3), 2006, p484 - 492 Journal Article, 2006

Non-Peer-Reviewed Publications

1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016 Conference Paper, 2016

12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012 Conference Paper, 2012

10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012 Conference Paper, 2012

Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179 Meeting Abstract, 2004

Research Expertise

Keywords

AGE-RELATED MACULOPATHY; Alzheimer's Disease; BLOOD-BRAIN-BARRIER; Cell signalling, proliferation & differentiation; Cellular Biology; ENDOTHELIAL CELLS; Genetics; INFLAMMATION; Molecular Biology; Molecular Genetics; Neurobiology; neurodegeneration; Neuroscience; siRNA technology; TIGHT JUNCTIONS; Transgenics; Vision

Recognition

Awards and Honours

Irish Research Council Laureate Award. 2018

Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award 2015

Association for Research in Vision and Ophthalmology, NEI travel Award 2015

Genentech/ARVO fellowship in recognition of my research on AMD 2015

Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA) 2013

"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations 2012

Appointed Senior Research Fellow, TCD 2012

Roche Research Award, Smurfit Institute of Genetics 2010

Fighting Blindness Ireland Research Scholarship 2002

Memberships

Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS). 2014 – Present