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Adrian Bracken
, Genetics

Biography

Dr. Adrian Bracken is an Associate Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. Three of the lab's papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 Nature Structural & Molecular Biology), the role of the tumour suppressor, CHD5, during neurogenesis (Egan et al., Developmental Cell. 2013) and the link between PCL1 and the p53 tumour suppressor in the regulation of cellular proliferation (Brien et al., Genes & Development, 2015). More recently, the lab has studied the Sin3a chromatin complex in mouse embryonic stem cells (Streubel et al., EMBO, 2017) and discovered a new family of vertebrate specific proteins that link nuclear receptor signalling and chromatin biology (Conway et al., Molecular Cell, 2018).

Publications and Further Research Outputs

Peer-Reviewed Publications

Bracken AP, Brien GL and Verrijzer CP., Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer. , Genes & Development, 33, 2019, p1 - 24 Journal Article, 2019

Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Bracken AP., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., Molecular Cell, 70, (3), 2018, p408-421 Journal Article, 2018 DOI

Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP*, Cagney G*. (* Equal last authors)., The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells., Molecular Cell, 70, (2), 2018, p371-379 Journal Article, 2018 DOI

Streubel, G., Fitzpatrick, Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal, EMBO Journal, 36, 2017, p2216 - 2232 Journal Article, 2017 DOI

Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes. in, editor(s)Vincenzo Pirrotta , Polycomb Group Proteins, 2017, pp57-80 , [Conway, EM., Bracken, AP.] Book Chapter, 2017 DOI

Erceg J, Pakozdi T, Marco-Ferreres R, Ghavi-Helm Y, Girardot C, Bracken AP, Furlong EE., Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements., Genes & Development, 31, (6), 2017, p590-602 Journal Article, 2017 DOI

Oliviero, G., Brien, G.L., Waston, A., Streubel, G., Jerman, E., Andrews, D., Doyle, B., Munawar, N., Wynne, K., Crean, J., Bracken, A.P., Cagney, G., Dynamic protein interactions of the polycomb repressive complex 2 during differentiation of pluripotent cells., Molecular and Cellular Proteomics, 15, (11), 2016, p3450-3460 Journal Article, 2016 DOI

Conway E, Healy E, Bracken AP., PRC2 mediated H3K27 methylations in cellular identity and cancer., Current Opinion in Cell Biology, 37, 2015, p42-48 Journal Article, 2015 DOI

Oliviero G, Munawar N, Watson A, Streubel G, Manning G, Bardwell V, Bracken AP, Cagney G, The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis., Scientific Reports, 5, 2015, p18388 Journal Article, 2015 TARA - Full Text DOI

Munawar, N., Olivero, G., Jerman, E., Doyle, B., Streubel, G., Wynne, K., Bracken, A., Cagney, G., Native gel analysis of macromolecular protein complexes in cultured mammalian cells., Proteomics, 15, (21), 2015, p3603-3612 Journal Article, 2015 DOI

Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP., Detection of novel germline mutations for breast cancer in non-BRCA1/2 families., FEBS J., 282, (17), 2015, p3424 - 3437 Journal Article, 2015 DOI

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP, A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence., Genes & Development, 29, (21), 2015, p2231-43 Journal Article, 2015 DOI TARA - Full Text

Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP., Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients., FEBS J, 282, (18), 2015, p3455 - 3473 Journal Article, 2015 DOI

Aloraifi, F., McCartan, D., McDevitt, T., Green, A.J., Bracken, A., Geraghty, J., Protein-truncating variants in moderate-risk breast cancer susceptibility genes: A meta-analysis of high-risk case-control screening studies., Cancer Genetics, 208, (9), 2015, p455-463 Journal Article, 2015 DOI

Aloraifi F, Alshehhi M, McDevitt T, Cody N, Meany M., O'Doherty A, Quinn CM, Green AJ, Bracken A, Geraghty JG, Comparison of BRCAx tumors with BRCA1 - BRCA2-carriers and non-familial breast cancer., EJSO, 41, (5), 2015, p641-646 Journal Article, 2015 DOI TARA - Full Text

Turner SA, Bracken AP., A "complex" issue: deciphering the role of variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145-146 Journal Article, 2013 DOI

Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP., CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression, Developmental Cell, 26, (3), 2013, p223-236 Journal Article, 2013 DOI TARA - Full Text

Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP, Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation, Nature Structural & Molecular Biology, 19, (12), 2012, p1273-1281 Journal Article, 2012 DOI URL

Lanigan F, Geraghty JG, Bracken AP., Transcriptional regulation of cellular senescence., Oncogene, 30, (26), 2011, p2901-2911 Journal Article, 2011 DOI

Bracken AP, Helin K., Polycomb group proteins: navigators of lineage pathways led astray in cancer, Nature Reviews Cancer, 9, (11), 2009, p773 - 784 Journal Article, 2009 TARA - Full Text DOI

Brien GL, Bracken AP., Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation, Seminars in Cell and Developmental Biology, 20, (7), 2009, p835 - 841 Journal Article, 2009 DOI TARA - Full Text

Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA., H3K79 methylation profiles define murine and human MLL-AF4 leukemias., Cancer Cell, 14, (5), 2008, p355-368 Journal Article, 2008 DOI

Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K., A model for transmission of the H3K27me3 epigenetic mark., Nature Cell Biology, 10, (11), 2008, p1291-1300 Journal Article, 2008 DOI

Pasini D, Bracken AP, Agger K, Christensen J, Hansen K, Cloos PA, Helin K., Regulation of stem cell differentiation by histone methyltransferases and demethylases., Cold Spring Harbor Symposia on Quantitative Biology, 73, 2008, p253-263 Journal Article, 2008 DOI

Del Arroyo, AG., El Messaoudi, S., Clark, P.A., James, M., Stott, F., Bracken, A., Helin, K., Peters, G., E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells., Cell Cycle, 6, (21), 2007, p2697-2705 Journal Article, 2007 DOI

Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH., Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus., The EMBO Journal, 26, (6), 2007, p1637-1648 Journal Article, 2007 DOI

Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH and Helin K., The Polycomb Group Proteins Bind Throughout the INK4A-ARF locus and are Disassociated in Senescent Cells., Genes and Development, 21, (5), 2007, p525 - 530 Journal Article, 2007 DOI

Pasini, D., Bracken, AP., Hansen, JB., Capillo, M., Helin, K., The polycomb group protein Suz12 is required for embryonic stem cell differentiation., Molecular and Cellular Biology, 27, (10), 2007, p3769-3779 Journal Article, 2007 DOI

Bracken AP, Dietrich N, Pasini D, Hansen KH and Helin K, Genome-wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions., Genes and Development, 20, (9), 2006, p1123 - 1136 Journal Article, 2006 TARA - Full Text DOI

Christensen, J., Cloos, P., Toftegaard, U., Klinkenberg, D., Bracken, AP., Trinh, E., Heeran, M., Di Stefano L, Helin, K., Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription, Nucleic Acids Research , 44, (17), 2005, p5458-5470 Journal Article, 2005 TARA - Full Text DOI

Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K., Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity., The EMBO Journal, 23, (20), 2004, p4061-4071 Journal Article, 2004 DOI

Bracken AP, Ciro M, Cocito A, Helin K., E2F target genes: unraveling the biology., Trends in Biochemical Sciences, 29, (8), 2004, p409-417 Journal Article, 2004 DOI

Pasini, D., Bracken, AP., Helin, K., Polycomb group proteins in cell cycle progression and cancer., Cell Cycle, 3, (4), 2004, p396-400 Journal Article, 2004

Ciro M, Bracken AP, Helin K., Profiling cancer., Current Opinion in Cell Biology, 15, (2), 2003, p213-20 Journal Article, 2003 DOI

Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K., EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer., The EMBO Journal, 22, (20), 2003, p5323-5335 Journal Article, 2003 DOI

Gao, G., Bracken, AP., Burkard, K., Pasini, D., Classon, M., Attwooll, C., Sagara, M., Imai, T., Helin, K., Zhao, J., NPAT expression is regulated by E2F and is essential for cell cycle progression., Molecular and Cellular Biology, 23, (8), 2003, p2821-2833 Journal Article, 2003 DOI

Müller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K., E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis., Genes & Development, 15, (3), 2001, p267-285 Journal Article, 2001 DOI

Bracken A. and U. Bond, Reassembly and protection of small nuclear ribonucleoprotein particles by heat shock proteins in yeast cells, RNA, 5, 1999, p1586 - 1596 Journal Article, 1999 URL

Non-Peer-Reviewed Publications

Brien GL, Bracken AP., The 3D Genome: EZH2 Comes into the Fold., Trends in Molecular Medicine, 25, (5), 2019, p362 - 365 Journal Article, 2019

Brien GL, Bracken AP., The PCL1-p53 axis promotes cellular quiescence., Cell Cycle, 15, (3), 2016, p305-306 Journal Article, 2016 DOI

Streubel G, Bracken AP., MED23: a new Mediator of H2B monoubiquitylation., The EMBO Journal, 34, (23), 2015, p2863-2864 Journal Article, 2015 DOI

Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Lim, D.A., Meshorer, E., Pombo, A., Sander, M., Xu, G.L., Stem cell epigenetics: Looking forward, Cell Stem Cell, 14, (6), 2014, p706-709 Journal Article, 2014 DOI

Turner, SA and Bracken AP., A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145 - 146 Journal Article, 2013 URL DOI TARA - Full Text

Research Expertise

Keywords

Cancer Genetics; Cellular identity; Chromatin biology; Epigenetics; Gene expression control; Polycomb proteins; Stem Cell Biology; The EZH2 oncogene

Recognition

Awards and Honours

Elected Fellow of Trinity College Dublin (FTCD) 2018-