Events
| Fri, 04/01/13 | Seminar by José Luis Riechmann (Center for Research in Agricultural Genomics, Barcelona): Genomic Analyses of Gene Regulatory Networks in Plants See more. Frank has invited Prof José Luis Riechmann from the Center for Research in Agricultural Genomics (CRAG) in Barcelona, to give a seminar this Friday at 1:00pm in the Smurfit Atrium. The title of his seminar will be "Genomic Analyses of Gene Regulatory Networks in Plants". Brief Biography: José Luis Riechmann is the director of the Center for Research in Agricultural Genomics (CRAG) in Barcelona. He is one of the leading authorities on plant transcription factors and has worked for many years on the characterisation of gene regulatory mechanisms underlying diverse processes during plant development. His recent papers include: Huang, W., Pérez-García, P., Pokhilko, A., Millar, A.J., Antoshechkin, I., Riechmann, J.L., Mas, P. (2012) Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator. Science 336, 75-79. Kaufmann, K., Wellmer, F., Muiño, J.M., Ferrier, T., Wuest, S.E., Kumar, V., Serrano-Mislata, A., Madueño, F., Krajewski, P., Meyerowitz, E.M., Angenent, G.C., and Riechmann, J.L. (2010) Orchestration of floral initiation by APETALA1. Science 328, 85-89. |
| Fri, 27/09/13 | Seminar by Scott Armstrong (Memorial Sloan-Kettering Cancer Center): Targeting Histone Methylation in Leukemia Stem Cells See more. Adrian has invited Prof Scott Armstrong, director of the Memorial Sloan-Kettering Leukemia Center, to give a seminar this Friday at 1:00pm in the Smurfit Atrium. The title of his seminar will be "Targeting Histone Methylation in Leukemia Stem Cells" Scott Armstrong's Research: The goal of Scott Armstrong's research program is to define genetic and epigenetic programs that control the extensive self-renewal properties associated with leukemia and other cancers. This knowledge is then used to develop rational approaches for potential new therapies. Experiments incorporate the use of sophisticated mouse models of leukemia and the characterization of human leukemia cells. Prof. Armstrong's lab recently identified leukemia stem cells in a model of human leukemia and demonstrated that acute myelogenous leukemia stem cells express a stem cell program in the context of a more differentiated cell type. This finding has important implications for therapeutic approaches that will target cancer stem cells. His lab also defined changes in chromosome structure as a critical initial step in leukemia development. These findings have prompted a search for therapies that can reverse this process and eradicate leukemia stem cells. Prof. Armstrong's work is driven by questions that are of immediate clinical relevance and a number of clinical trials have been developed as a direct result of this work. Selected publications: Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA , Armstrong SA. 2012. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell, (1934-5909), 2012 Sept 07; 11 (3)429. Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis K, Lane SW, Armstrong SA. Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib Resistant Leukemia Stem Cells in CML. Cell Stem Cell, 2012 Apr 6;10(4)412-24. Neff TA, Sinha AU, Kluk MJ, Zhu N, Khattab M, Stein L, Zie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc. Natl. Acad. Sci. 2012 Mar 27;109(13)5028-33. Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Mancarci OB, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602. Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA. MLL-rearranged Leukemia is Dependent on Aberrant H3K79 Methylation by DOT1L. Cancer Cell 2011, Jul 12;20(1)66-78. Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, Johnson LD, Scott MP, Smith JJ, Xiao Y, Jin L, Kuntz KW, Chesworth R, Moyer MP, Bernt KM, Tsend JC, Kung AL, Armstrong SA, Copeland RA, Richon VM, Pollock RM. Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor. Cancer Cell 2011, Jul 12;20(1)53-65. Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010 Mar 26;327(5973):1650-3. Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008 Nov 4; 15(5):355-68. Wei G, Twomey D, Lamb J, Agarwal J, Stam R, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA. Gene expression-based chemical genomics identifies rapamycin as a modulator of glucocorticoid resistance. Cancer Cell. 2006: 10, 331-42. Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA. Transformation from committed progenitor to leukaemia stem cell initiated by MLL AF-9. Nature. 2006: 442, 818-22. |
| Tue, 03/05/13 | Seminar by Peter Kirwan (Gurdon Institute, University of Cambridge): Modelling human cortical networks from pluripotent stem cells in development and disease See more. SPECIAL SEMINAR, 1 pm, Genetics Atrium Peter Kirwan is a graduate of the Trinity College Genetics department, currently completing his PhD with Rick Livesey at Cambridge, where they are pioneering the derivation of cortical neuronal cell-types from induced pluripotent stem cells from human patients to model cortical development and disease.
Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.
A human stem cell model of early Alzheimer's disease pathology in Down syndrome.
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
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| Tue, 23/04/13 | Seminar by Shane McCarthy (Cold Spring Harbor Laboratory): Harvesting Rare Variation in Schizophrenia See more. SPECIAL SEMINAR, 1 pm, Atrium Shane McCarthy is a genomics researcher studying the genetics of psychiatric and neurodevelopmental disorders. He has helped pioneer the application of whole-genome array and sequencing approaches to identify rare mutations causing schizophrenia, autism and related conditions.
High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia.
High frequencies of de novo CNVs in bipolar disorder and schizophrenia.
Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders.
Microduplications of 16p11.2 are associated with schizophrenia.
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
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| Fri, 22/03/13 | Seminar by Jose Luis Riechmann |
| Fri, 15/03/13 | Seminar by Ludovic Orlando |
| Fri, 08/03/13 | Seminar by Steven Spoel |
| Fri, 15/02/13 | Seminar by Dr John Stingl (University of Cambridge): Mammary stem and progenitor cells: Understanding the cellular context of breast cancer See more. Adrian has invited Dr John Stingl from the Department of Oncology, University of Cambridge to give a seminar this Friday at 1:00pm in the Smurfit Atrium. The title of his seminar will be "Mammary stem and progenitor cells: Understanding the cellular context of breast cancer" Brief Biography: The research of Dr John Stingl focuses on identifying stem and progenitor cells in both the human and mouse mammary glands. He is interested in these cells because cancer theory suggests that it is these cells that are the initial targets for malignant transformation in breast cancer. He is also interested in understanding the influence of common breast cancer-associated mutations on normal breast stem and progenitor cell function and identifying the cell of origin of different types of breast tumours. Key publications: Enzymatic dissociation, flow cytometric analysis, and culture of normal mouse mammary tissue. Prater M, Shehata M, Watson CJ, Stingl J. Methods Mol Biol. 2013;946:395-409. doi: 10.1007/978-1-62703-128-8_25.
TGFbeta induces the formation of tumour-initiating cells in claudinlow breast cancer.
Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay.
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.
Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis.
Purification and unique properties of mammary epithelial stem cells.
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| Fri, 08/02/13 | Seminar by Dr Adrian Bracken (TCD): Epigenetic 'reader' proteins in stem cells and cancer |
| Fri, 01/02/13 | Seminar by Prof Ken Wolfe (TCD): Yeast genome evolution - Shuffling and shrinking |
| Fri, 25/01/13 | Seminar by Dagmar Kulms (University of Dresden): Breaking TRAIL resistance of malignant melanoma |