Selected Publications
| 1 | Unlocking potential: the role of the electron transport chain in immunometabolism.
Zotta A, O'Neill LAJ, Yin M.Trends Immunol. 2024 Mar 18:S1471-4906(24)00027-9. doi: 10.1016/j.it.2024.02.002. Online ahead of print.PMID: 38503657 Review. |
| 2 | Metabolic regulation of type I interferon production.
O'Carroll SM, Henkel FDR, O'Neill LAJ.Immunol Rev. 2024 Mar 11. doi: 10.1111/imr.13318. Online ahead of print.PMID: 38465724 Review. |
| 3 | Itaconate boosts malaria via induction of PD-L1.
Min Y, O'Neill LAJ.Cell Metab. 2024 Mar 5;36(3):457-458. doi: 10.1016/j.cmet.2024.02.005.PMID: 38447526 |
| 4 | A break in mitochondrial endosymbiosis as a basis for inflammatory diseases.
Murphy MP, O'Neill LAJ.Nature. 2024 Feb;626(7998):271-279. doi: 10.1038/s41586-023-06866-z. Epub 2024 Feb 7.PMID: 38326590 Review. |
| 5 | Characterization and inhibition of inflammasome responses in severe and non-severe asthma.
Horvat JC, Kim RY, Weaver N, Augood C, Brown AC, Donovan C, Dupre P, Gunawardhana L, Mayall JR, Hansbro NG, Robertson AAB, O'Neill LAJ, Cooper MA, Holliday EG, Hansbro PM, Gibson PG.Respir Res. 2023 Dec 4;24(1):303. doi: 10.1186/s12931-023-02603-2.PMID: 38044426 Free PMC article. |
| 6 | 4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development.
Yin M, Wadhwa R, Marshall JE, Gillis CM, Kim RY, Dua K, Palsson-McDermott EM, Fallon PG, Hansbro PM, O'Neill LAJ. |
| 7 | 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2.
Diskin C, Day EA, Henry ÓC, Toller-Kawahisa JE, O'Neill LAJ. |
| 8 | NLRP12 drives PANoptosis in response to heme.
Henkel FDR, O'Neill LAJ. |
| 9 | Fumarate hydratase as a metabolic regulator of immunity.
Peace CG, O'Carroll SM, O'Neill LAJ. |
| 10 | Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. |
| 11 | An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation.
Ryan TAJ, O'Neill LAJ. |
12 |
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ. |
| 13 | Protein targeting by the itaconate family in immunity and inflammation.
Day EA, O'Neill LAJ. |
14 |
How neutrophil metabolism affects bacterial killing.
Toller-Kawahisa JE, O'Neill LAJ. |
| 15 | Of Flies and Men-The Discovery of TLRs.
Weiss HJ, O'Neill LAJ. |
16 |
The itaconate family of immunomodulators grows.
McGettrick AF, O'Neill LAJ. |
17 |
Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities.
Ryan TAJ, O'Neill LAJ. |
| 18 | Creating ATP via creatine kinase B for NLRP3 activation. Toller-Kawahisa JE, O'Neill LAJ. |
19 |
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants.
Ryan TAJ, Preston RJS, O'Neill LAJ. |
| 20 | Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ. |
21 |
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Ryan DG, Knatko EV, Casey AM, Hukelmann JL, Dayalan Naidu S, Brenes AJ, Ekkunagul T, Baker C, Higgins M, Tronci L, Nikitopolou E, Honda T, Hartley RC, O'Neill LAJ, Frezza C, Lamond AI, Abramov AY, Arthur JSC, Cantrell DA, Murphy MP, Dinkova-Kostova AT. |
| 22 | The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2.
Diskin C, Corcoran SE, Tyrrell VJ, McGettrick AF, Zaslona Z, O'Donnell VB, Nolan DP, O'Neill LAJ. |
23 |
4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages.
Diskin C, Zotta A, Corcoran SE, Tyrrell VJ, Zaslona Z, O'Donnell VB, O'Neill LAJ. |
| 24 | The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ. |
25 |
Caspase-11 promotes allergic airway inflammation.
Zasłona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM, Diskin C, Banahan K, Ryan DG, Hooftman A, Misiak A, Kearney J, Lochnit G, Bertrams W, Greulich T, Schmeck B, McElvaney OJ, Mills KHG, Lavelle EC, Wygrecka M, Creagh EM, O'Neill LAJ. |
26 |
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.
Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott EM, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KHG, O'Neill LAJ. |
27 |
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ. |
28 |
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.
Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ. |