St. Vincent's University Hospital Protocol Outline
What participation involves:
- Screening call/visit
- Lumbar puncture for biomarker analysis
- Paired blood test for albumin CSF to serum ratio
- Blood biomarker analysis
- APOE genotyping
- Cognitive testing to determine cohort category
NB: Must retain capacity to consent
Cognitive Testing:
•RBANS (Repeatable Battery for Assessment of Neurological Status)
•CAMCOG (Cambridge Cognitive Examination)
•Montreal Cognitive Assessment (MoCA)
•CESD (Centre for Epidemiological Studies Depression scale)
•Bristol Activities of Daily Living (B-ADL)
•Clinical Dementia Rating Scale (CDR)
Exclusion Criteria:
•Psychiatric illness: major depression, bipolar affective disorder and schizophrenia or schizoaffective disorder
•Normal pressure hydrocephalus
•Seizure disorder
•Brain tumour
•Alcohol or drug abuse/dependence (within the past 2 years)
•History of significant head trauma followed by persistent neurologic defaults
•Known structural brain abnormalities
•History of stroke disease
•Screening/baseline MRI scan with evidence of infection, infarction, or other focal lesions
•Subjects with multiple lacunes or lacunes in a critical memory structure shown on neuroimaging.
•Any significant systemic illness or unstable medical condition, which could lead to difficulty complying with the protocol.
•Current use of warfarin (exclusionary for lumbar puncture).
Target Recruitment:
Site |
Possible AD/MCI |
Cognitive Impairment in Multiple Sclerosis |
Early Onset Neurodegeneration |
|---|---|---|---|
| St. Vincent's University Hospital | 20 |
40 |
20 |
Follow Up:
•Possible AD: follow up for 1year with repeat cognitive and clinical assessments
•MCI: annually until transition to dementia or for 3 years (with annual cognitive and clinical assessments) or until a clinical diagnosis of dementia can be confirmed from repeat cognitive and clinical assessments
•Participants will be contacted by phone at an interval of 6 months to check their status
•F/U CSF and bloods @ 1yr and at time of clinical transition to dementia and/or after transition - Repeat consenting