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Professor Luke O'Neill

red line Professor Luke O'Neill

The group of Prof O誰eill is investigating the molecular and cellular basis to inflammation and innate immunity. Particular areas of interest include Toll-like receptors, proinflammatory cytokines, signal transduction in the immune system, and molecular analysis of inflammatory and infectious diseases.

Figures of Research Work This figure depicts the 4 major families of pathogen sensors that sense the microbial world during infection, triggering signalling pathways that culminate in increased expression of immune and inflammatory genes.
Figures of Research Work This figure depicts the 4 major families of pathogen sensors that sense the microbial world during infection, triggering signalling pathways that culminate in increased expression of immune and inflammatory genes.
We are currently investigating the biochemistry and genetics of Toll-IL-1 receptor signaling adapters, notably the adapters Mal and Tram. We are also interested in the regulation of caspase- 1-containing inflammasomes.

Key Publications
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Bruton's tyrosine kinase is a TIR domain binding protein that participates in NFkappa B activation by Toll-like receptor 4.
J Biol Chem. 278(28):26258-64, 2003.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA.

ST2 is an inhibitor of IL-1R and TLR4 signalling and maintains endotoxin tolerance.
Nature Immunol. 5, 373-379, 2004.
Brint, E, Xu, D, Liu, H, Dunne, A, McKenzie, A, O誰eill, LAJ* and Liew FY* (*Joint senior authorship)
Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation.
Nature Immunol. 7(2):148-55, 2006.
Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O誰eill LA* and Hertzog P* (*Joint senior authorship).

A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis.
Nature Genetics 39(4):523-8, 2007.
Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O誰eill LAJ* and Hill, AVS*. (*Joint Senior Author)

The family of five: TIR domain containing adapters in TLR signalling.
Nat Rev Immunol 7, 353-364, 2007.
O誰eill LA and Bowie AG.

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Last updated: May 9, 2008.