7. Study Assessments and Procedures

7.1 Summary of Study Procedures:

Patients who consent to participate in this study will undergo:

• LP for biomarker analysis.
• Paired blood test for albumin CSF- to- serum ratio.  
• Blood Biomarker Analysis.
• APOE genotyping.
• Cognitive testing.

7.2 CSF COLLECTION

Standard Operation Procedure for CSF Collection (SOP)

7.3 BLOOD COLLECTION

Standard Operating Procedure for Blood Collection (SOP)

7.4 Cognitive Testing Battery

Participants will undergo a battery of tests:

• RBANS  (Repeatable Battery for Assessment of Neurological Status)
• CAMCOG  (Cambridge Cognitive Examination)
• MoCA (Montreal Cognitive Assessment)
• CESD  (Centre for Epidemiological Studies Depression scale)
• B-ADL (Bristol Activities of Daily Living)
• CDR    (Clinical Dementia Rating Scale)

Cognitive scores of all patients will be recorded and stored in a database following each assessment.  Following each yearly assessment the test scores will be reviewed to determine if the participant has transitioned from MCI to dementia at which point they will exit the study. The PIN will only identify patient scores. At the study endpoint statistical analysis will be completed on the data.